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Search of human proteins with 19924165
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo
sapiens]
(2347 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens] 4787 0.0
gi|29029632 anaplastic lymphoma kinase [Homo sapiens] 301 4e-81
gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precurs... 285 3e-76
gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precurs... 285 3e-76
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo... 270 2e-71
gi|119395738 insulin receptor isoform Short precursor [Homo sapi... 267 1e-70
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens] 267 1e-70
gi|31657140 insulin receptor-related receptor precursor [Homo sa... 258 6e-68
gi|208879423 leukocyte receptor tyrosine kinase isoform 3 precur... 256 2e-67
gi|10862701 ret proto-oncogene isoform c [Homo sapiens] 234 1e-60
gi|10862703 ret proto-oncogene isoform a [Homo sapiens] 234 1e-60
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 223 1e-57
gi|66932918 MER receptor tyrosine kinase precursor [Homo sapiens] 222 4e-57
gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens] 220 1e-56
gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens] 220 1e-56
gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens] 220 1e-56
gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens] 220 1e-56
gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens] 220 1e-56
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 219 2e-56
gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens] 219 3e-56
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu... 218 6e-56
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 218 6e-56
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu... 218 6e-56
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu... 218 6e-56
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu... 218 6e-56
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu... 218 6e-56
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu... 218 6e-56
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 218 6e-56
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 218 7e-56
gi|32967311 ephrin receptor EphA2 [Homo sapiens] 217 1e-55
>gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]
Length = 2347
Score = 4787 bits (12416), Expect = 0.0
Identities = 2347/2347 (100%), Positives = 2347/2347 (100%)
Query: 1 MKNIYCLIPKLVNFATLGCLWISVVQCTVLNSCLKSCVTNLGQQLDLGTPHNLSEPCIQG 60
MKNIYCLIPKLVNFATLGCLWISVVQCTVLNSCLKSCVTNLGQQLDLGTPHNLSEPCIQG
Sbjct: 1 MKNIYCLIPKLVNFATLGCLWISVVQCTVLNSCLKSCVTNLGQQLDLGTPHNLSEPCIQG 60
Query: 61 CHFWNSVDQKNCALKCRESCEVGCSSAEGAYEEEVLENADLPTAPFASSIGSHNMTLRWK 120
CHFWNSVDQKNCALKCRESCEVGCSSAEGAYEEEVLENADLPTAPFASSIGSHNMTLRWK
Sbjct: 61 CHFWNSVDQKNCALKCRESCEVGCSSAEGAYEEEVLENADLPTAPFASSIGSHNMTLRWK 120
Query: 121 SANFSGVKYIIQWKYAQLLGSWTYTKTVSRPSYVVKPLHPFTEYIFRVVWIFTAQLQLYS 180
SANFSGVKYIIQWKYAQLLGSWTYTKTVSRPSYVVKPLHPFTEYIFRVVWIFTAQLQLYS
Sbjct: 121 SANFSGVKYIIQWKYAQLLGSWTYTKTVSRPSYVVKPLHPFTEYIFRVVWIFTAQLQLYS 180
Query: 181 PPSPSYRTHPHGVPETAPLIRNIESSSPDTVEVSWDPPQFPGGPILGYNLRLISKNQKLD 240
PPSPSYRTHPHGVPETAPLIRNIESSSPDTVEVSWDPPQFPGGPILGYNLRLISKNQKLD
Sbjct: 181 PPSPSYRTHPHGVPETAPLIRNIESSSPDTVEVSWDPPQFPGGPILGYNLRLISKNQKLD 240
Query: 241 AGTQRTSFQFYSTLPNTIYRFSIAAVNEVGEGPEAESSITTSSSAVQQEEQWLFLSRKTS 300
AGTQRTSFQFYSTLPNTIYRFSIAAVNEVGEGPEAESSITTSSSAVQQEEQWLFLSRKTS
Sbjct: 241 AGTQRTSFQFYSTLPNTIYRFSIAAVNEVGEGPEAESSITTSSSAVQQEEQWLFLSRKTS 300
Query: 301 LRKRSLKHLVDEAHCLRLDAIYHNITGISVDVHQQIVYFSEGTLIWAKKAANMSDVSDLR 360
LRKRSLKHLVDEAHCLRLDAIYHNITGISVDVHQQIVYFSEGTLIWAKKAANMSDVSDLR
Sbjct: 301 LRKRSLKHLVDEAHCLRLDAIYHNITGISVDVHQQIVYFSEGTLIWAKKAANMSDVSDLR 360
Query: 361 IFYRGSGLISSISIDWLYQRMYFIMDELVCVCDLENCSNIEEITPPSISAPQKIVADSYN 420
IFYRGSGLISSISIDWLYQRMYFIMDELVCVCDLENCSNIEEITPPSISAPQKIVADSYN
Sbjct: 361 IFYRGSGLISSISIDWLYQRMYFIMDELVCVCDLENCSNIEEITPPSISAPQKIVADSYN 420
Query: 421 GYVFYLLRDGIYRADLPVPSGRCAEAVRIVESCTLKDFAIKPQAKRIIYFNDTAQVFMST 480
GYVFYLLRDGIYRADLPVPSGRCAEAVRIVESCTLKDFAIKPQAKRIIYFNDTAQVFMST
Sbjct: 421 GYVFYLLRDGIYRADLPVPSGRCAEAVRIVESCTLKDFAIKPQAKRIIYFNDTAQVFMST 480
Query: 481 FLDGSASHLILPRIPFADVKSFACENNDFLVTDGKVIFQQDALSFNEFIVGCDLSHIEEF 540
FLDGSASHLILPRIPFADVKSFACENNDFLVTDGKVIFQQDALSFNEFIVGCDLSHIEEF
Sbjct: 481 FLDGSASHLILPRIPFADVKSFACENNDFLVTDGKVIFQQDALSFNEFIVGCDLSHIEEF 540
Query: 541 GFGNLVIFGSSSQLHPLPGRPQELSVLFGSHQALVQWKPPALAIGANVILISDIIELFEL 600
GFGNLVIFGSSSQLHPLPGRPQELSVLFGSHQALVQWKPPALAIGANVILISDIIELFEL
Sbjct: 541 GFGNLVIFGSSSQLHPLPGRPQELSVLFGSHQALVQWKPPALAIGANVILISDIIELFEL 600
Query: 601 GPSAWQNWTYEVKVSTQDPPEVTHIFLNISGTMLNVPELQSAMKYKVSVRASSPKRPGPW 660
GPSAWQNWTYEVKVSTQDPPEVTHIFLNISGTMLNVPELQSAMKYKVSVRASSPKRPGPW
Sbjct: 601 GPSAWQNWTYEVKVSTQDPPEVTHIFLNISGTMLNVPELQSAMKYKVSVRASSPKRPGPW 660
Query: 661 SEPSVGTTLVPASEPPFIMAVKEDGLWSKPLNSFGPGEFLSSDIGNVSDMDWYNNSLYYS 720
SEPSVGTTLVPASEPPFIMAVKEDGLWSKPLNSFGPGEFLSSDIGNVSDMDWYNNSLYYS
Sbjct: 661 SEPSVGTTLVPASEPPFIMAVKEDGLWSKPLNSFGPGEFLSSDIGNVSDMDWYNNSLYYS 720
Query: 721 DTKGDVFVWLLNGTDISENYHLPSIAGAGALAFEWLGHFLYWAGKTYVIQRQSVLTGHTD 780
DTKGDVFVWLLNGTDISENYHLPSIAGAGALAFEWLGHFLYWAGKTYVIQRQSVLTGHTD
Sbjct: 721 DTKGDVFVWLLNGTDISENYHLPSIAGAGALAFEWLGHFLYWAGKTYVIQRQSVLTGHTD 780
Query: 781 IVTHVKLLVNDMVVDSVGGYLYWTTLYSVESTRLNGESSLVLQTQPWFSGKKVIALTLDL 840
IVTHVKLLVNDMVVDSVGGYLYWTTLYSVESTRLNGESSLVLQTQPWFSGKKVIALTLDL
Sbjct: 781 IVTHVKLLVNDMVVDSVGGYLYWTTLYSVESTRLNGESSLVLQTQPWFSGKKVIALTLDL 840
Query: 841 SDGLLYWLVQDSQCIHLYTAVLRGQSTGDTTITEFAAWSTSEISQNALMYYSGRLFWING 900
SDGLLYWLVQDSQCIHLYTAVLRGQSTGDTTITEFAAWSTSEISQNALMYYSGRLFWING
Sbjct: 841 SDGLLYWLVQDSQCIHLYTAVLRGQSTGDTTITEFAAWSTSEISQNALMYYSGRLFWING 900
Query: 901 FRIITTQEIGQKTSVSVLEPARFNQFTIIQTSLKPLPGNFSFTPKVIPDSVQESSFRIEG 960
FRIITTQEIGQKTSVSVLEPARFNQFTIIQTSLKPLPGNFSFTPKVIPDSVQESSFRIEG
Sbjct: 901 FRIITTQEIGQKTSVSVLEPARFNQFTIIQTSLKPLPGNFSFTPKVIPDSVQESSFRIEG 960
Query: 961 NASSFQILWNGPPAVDWGVVFYSVEFSAHSKFLASEQHSLPVFTVEGLEPYALFNLSVTP 1020
NASSFQILWNGPPAVDWGVVFYSVEFSAHSKFLASEQHSLPVFTVEGLEPYALFNLSVTP
Sbjct: 961 NASSFQILWNGPPAVDWGVVFYSVEFSAHSKFLASEQHSLPVFTVEGLEPYALFNLSVTP 1020
Query: 1021 YTYWGKGPKTSLSLRAPETVPSAPENPRIFILPSGKCCNKNEVVVEFRWNKPKHENGVLT 1080
YTYWGKGPKTSLSLRAPETVPSAPENPRIFILPSGKCCNKNEVVVEFRWNKPKHENGVLT
Sbjct: 1021 YTYWGKGPKTSLSLRAPETVPSAPENPRIFILPSGKCCNKNEVVVEFRWNKPKHENGVLT 1080
Query: 1081 KFEIFYNISNQSITNKTCEDWIAVNVTPSVMSFQLEGMSPRCFIAFQVRAFTSKGPGPYA 1140
KFEIFYNISNQSITNKTCEDWIAVNVTPSVMSFQLEGMSPRCFIAFQVRAFTSKGPGPYA
Sbjct: 1081 KFEIFYNISNQSITNKTCEDWIAVNVTPSVMSFQLEGMSPRCFIAFQVRAFTSKGPGPYA 1140
Query: 1141 DVVKSTTSEINPFPHLITLLGNKIVFLDMDQNQVVWTFSAERVISAVCYTADNEMGYYAE 1200
DVVKSTTSEINPFPHLITLLGNKIVFLDMDQNQVVWTFSAERVISAVCYTADNEMGYYAE
Sbjct: 1141 DVVKSTTSEINPFPHLITLLGNKIVFLDMDQNQVVWTFSAERVISAVCYTADNEMGYYAE 1200
Query: 1201 GDSLFLLHLHNRSSSELFQDSLVFDITVITIDWISRHLYFALKESQNGMQVFDVDLEHKV 1260
GDSLFLLHLHNRSSSELFQDSLVFDITVITIDWISRHLYFALKESQNGMQVFDVDLEHKV
Sbjct: 1201 GDSLFLLHLHNRSSSELFQDSLVFDITVITIDWISRHLYFALKESQNGMQVFDVDLEHKV 1260
Query: 1261 KYPREVKIHNRNSTIISFSVYPLLSRLYWTEVSNFGYQMFYYSIISHTLHRILQPTATNQ 1320
KYPREVKIHNRNSTIISFSVYPLLSRLYWTEVSNFGYQMFYYSIISHTLHRILQPTATNQ
Sbjct: 1261 KYPREVKIHNRNSTIISFSVYPLLSRLYWTEVSNFGYQMFYYSIISHTLHRILQPTATNQ 1320
Query: 1321 QNKRNQCSCNVTEFELSGAMAIDTSNLEKPLIYFAKAQEIWAMDLEGCQCWRVITVPAML 1380
QNKRNQCSCNVTEFELSGAMAIDTSNLEKPLIYFAKAQEIWAMDLEGCQCWRVITVPAML
Sbjct: 1321 QNKRNQCSCNVTEFELSGAMAIDTSNLEKPLIYFAKAQEIWAMDLEGCQCWRVITVPAML 1380
Query: 1381 AGKTLVSLTVDGDLIYWIITAKDSTQIYQAKKGNGAIVSQVKALRSRHILAYSSVMQPFP 1440
AGKTLVSLTVDGDLIYWIITAKDSTQIYQAKKGNGAIVSQVKALRSRHILAYSSVMQPFP
Sbjct: 1381 AGKTLVSLTVDGDLIYWIITAKDSTQIYQAKKGNGAIVSQVKALRSRHILAYSSVMQPFP 1440
Query: 1441 DKAFLSLASDTVEPTILNATNTSLTIRLPLAKTNLTWYGITSPTPTYLVYYAEVNDRKNS 1500
DKAFLSLASDTVEPTILNATNTSLTIRLPLAKTNLTWYGITSPTPTYLVYYAEVNDRKNS
Sbjct: 1441 DKAFLSLASDTVEPTILNATNTSLTIRLPLAKTNLTWYGITSPTPTYLVYYAEVNDRKNS 1500
Query: 1501 SDLKYRILEFQDSIALIEDLQPFSTYMIQIAVKNYYSDPLEHLPPGKEIWGKTKNGVPEA 1560
SDLKYRILEFQDSIALIEDLQPFSTYMIQIAVKNYYSDPLEHLPPGKEIWGKTKNGVPEA
Sbjct: 1501 SDLKYRILEFQDSIALIEDLQPFSTYMIQIAVKNYYSDPLEHLPPGKEIWGKTKNGVPEA 1560
Query: 1561 VQLINTTVRSDTSLIISWRESHKPNGPKESVRYQLAISHLALIPETPLRQSEFPNGRLTL 1620
VQLINTTVRSDTSLIISWRESHKPNGPKESVRYQLAISHLALIPETPLRQSEFPNGRLTL
Sbjct: 1561 VQLINTTVRSDTSLIISWRESHKPNGPKESVRYQLAISHLALIPETPLRQSEFPNGRLTL 1620
Query: 1621 LVTRLSGGNIYVLKVLACHSEEMWCTESHPVTVEMFNTPEKPYSLVPENTSLQFNWKAPL 1680
LVTRLSGGNIYVLKVLACHSEEMWCTESHPVTVEMFNTPEKPYSLVPENTSLQFNWKAPL
Sbjct: 1621 LVTRLSGGNIYVLKVLACHSEEMWCTESHPVTVEMFNTPEKPYSLVPENTSLQFNWKAPL 1680
Query: 1681 NVNLIRFWVELQKWKYNEFYHVKTSCSQGPAYVCNITNLQPYTSYNVRVVVVYKTGENST 1740
NVNLIRFWVELQKWKYNEFYHVKTSCSQGPAYVCNITNLQPYTSYNVRVVVVYKTGENST
Sbjct: 1681 NVNLIRFWVELQKWKYNEFYHVKTSCSQGPAYVCNITNLQPYTSYNVRVVVVYKTGENST 1740
Query: 1741 SLPESFKTKAGVPNKPGIPKLLEGSKNSIQWEKAEDNGCRITYYILEIRKSTSNNLQNQN 1800
SLPESFKTKAGVPNKPGIPKLLEGSKNSIQWEKAEDNGCRITYYILEIRKSTSNNLQNQN
Sbjct: 1741 SLPESFKTKAGVPNKPGIPKLLEGSKNSIQWEKAEDNGCRITYYILEIRKSTSNNLQNQN 1800
Query: 1801 LRWKMTFNGSCSSVCTWKSKNLKGIFQFRVVAANNLGFGEYSGISENIILVGDDFWIPET 1860
LRWKMTFNGSCSSVCTWKSKNLKGIFQFRVVAANNLGFGEYSGISENIILVGDDFWIPET
Sbjct: 1801 LRWKMTFNGSCSSVCTWKSKNLKGIFQFRVVAANNLGFGEYSGISENIILVGDDFWIPET 1860
Query: 1861 SFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLAN 1920
SFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLAN
Sbjct: 1861 SFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLAN 1920
Query: 1921 ACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVK 1980
ACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVK
Sbjct: 1921 ACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVK 1980
Query: 1981 TLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRK 2040
TLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRK
Sbjct: 1981 TLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRK 2040
Query: 2041 ARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKI 2100
ARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKI
Sbjct: 2041 ARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKI 2100
Query: 2101 GDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQ 2160
GDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQ
Sbjct: 2101 GDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQ 2160
Query: 2161 PYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRN 2220
PYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRN
Sbjct: 2161 PYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRN 2220
Query: 2221 FFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATE 2280
FFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATE
Sbjct: 2221 FFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATE 2280
Query: 2281 CGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHS 2340
CGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHS
Sbjct: 2281 CGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHS 2340
Query: 2341 GYGDGSD 2347
GYGDGSD
Sbjct: 2341 GYGDGSD 2347
>gi|29029632 anaplastic lymphoma kinase [Homo sapiens]
Length = 1620
Score = 301 bits (772), Expect = 4e-81
Identities = 180/462 (38%), Positives = 277/462 (59%), Gaps = 38/462 (8%)
Query: 1858 PETSFILTIIVGIF---LVVTIPLTF----VWHRRLKNQKSAKEGVTVLINEDKELAELR 1910
PE L++I+ + LV + L F + +RR + A + L + + +L++LR
Sbjct: 1027 PEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQ--MELQSPEYKLSKLR 1084
Query: 1911 GLAAGVGL-ANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILG 1969
N C+A T I +L PR+ +TL LG GAFGEVYEG V +
Sbjct: 1085 TSTIMTDYNPNYCFAGKT----SSISDLKEVPRKNITLIRGLGHGAFGEVYEGQ-VSGMP 1139
Query: 1970 VGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELM 2029
++VAVKTL + ++Q++++FL EA ++SKFNH NI++ +GV L + P++I+LELM
Sbjct: 1140 NDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELM 1199
Query: 2030 EGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSV 2089
GGDL ++LR+ R L ++DL+ + DI+ GC YLE HFIHRD+AARNCL++
Sbjct: 1200 AGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTC 1259
Query: 2090 KDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGI 2149
R+ KIGDFG+ARDIY+ YYRK G +LPV+WM PE+ M+GIFT+++D WSFG+
Sbjct: 1260 PG--PGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGV 1317
Query: 2150 LIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFH 2209
L+WEI +LG+ PYP+ SN +VL +V +GGR++PP+NCP ++ +MTQCW +P+ RP F
Sbjct: 1318 LLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFA 1377
Query: 2210 RIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNR 2269
I ++++ Y ++D VIN + E G ++ ++ +PV K+
Sbjct: 1378 IILERIE----------YCTQD----PDVINTALPIEYGPLV--EEEEKVPV---RPKDP 1418
Query: 2270 EGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHA 2311
EG+ ++++ + + EE+S + S G K K+P A
Sbjct: 1419 EGVPPLLVSQQAKREEERSPAAPPPLPTTSSG--KAAKKPTA 1458
>gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precursor
[Homo sapiens]
Length = 864
Score = 285 bits (730), Expect = 3e-76
Identities = 141/307 (45%), Positives = 206/307 (67%), Gaps = 10/307 (3%)
Query: 1945 LTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKF 2004
+TL LG GAFGEVYEG + + G S ++VA+KTL + + Q++++FL EA ++SKF
Sbjct: 510 VTLLRALGHGAFGEVYEGLVIGLPG-DSSPLQVAIKTLPELCSPQDELDFLMEALIISKF 568
Query: 2005 NHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDIS 2064
H NI++ +G+ L P+ I+LELM GGD+ ++LR +R L + DL+ L DI+
Sbjct: 569 RHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIA 628
Query: 2065 KGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLP 2124
+GC YLE HFIHRD+AARNCL+S + R+ KIGDFG+ARDIY+ YYR+ LLP
Sbjct: 629 QGCHYLEENHFIHRDIAARNCLLSCAGPS--RVAKIGDFGMARDIYRASYYRRGDRALLP 686
Query: 2125 VRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPR 2184
V+WM PE+ ++GIFT+++D WSFG+L+WEI +LG+ PYP +N +VL++V GGR++PPR
Sbjct: 687 VKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPR 746
Query: 2185 NCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQ-------LFRNFFLNSIYKSRDEANNSG 2237
CP ++ +MTQCW EP+ RP+F I ++LQ + + + + +E SG
Sbjct: 747 GCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSG 806
Query: 2238 VINESFE 2244
+ N S E
Sbjct: 807 LGNRSLE 813
>gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precursor
[Homo sapiens]
Length = 803
Score = 285 bits (730), Expect = 3e-76
Identities = 141/307 (45%), Positives = 206/307 (67%), Gaps = 10/307 (3%)
Query: 1945 LTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKF 2004
+TL LG GAFGEVYEG + + G S ++VA+KTL + + Q++++FL EA ++SKF
Sbjct: 449 VTLLRALGHGAFGEVYEGLVIGLPG-DSSPLQVAIKTLPELCSPQDELDFLMEALIISKF 507
Query: 2005 NHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDIS 2064
H NI++ +G+ L P+ I+LELM GGD+ ++LR +R L + DL+ L DI+
Sbjct: 508 RHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIA 567
Query: 2065 KGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLP 2124
+GC YLE HFIHRD+AARNCL+S + R+ KIGDFG+ARDIY+ YYR+ LLP
Sbjct: 568 QGCHYLEENHFIHRDIAARNCLLSCAGPS--RVAKIGDFGMARDIYRASYYRRGDRALLP 625
Query: 2125 VRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPR 2184
V+WM PE+ ++GIFT+++D WSFG+L+WEI +LG+ PYP +N +VL++V GGR++PPR
Sbjct: 626 VKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPR 685
Query: 2185 NCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQ-------LFRNFFLNSIYKSRDEANNSG 2237
CP ++ +MTQCW EP+ RP+F I ++LQ + + + + +E SG
Sbjct: 686 GCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSG 745
Query: 2238 VINESFE 2244
+ N S E
Sbjct: 746 LGNRSLE 752
>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
sapiens]
Length = 1367
Score = 270 bits (689), Expect = 2e-71
Identities = 157/397 (39%), Positives = 222/397 (55%), Gaps = 47/397 (11%)
Query: 1834 NNLGFGEYSGISENIILVGDDFWIPETSFILTIIVG----IFLVVTIPLT---------- 1879
N L G Y+ + L G+ W F + G I L++ +P+
Sbjct: 894 NRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKTGYENFIHLIIALPVAVLLIVGGLVI 953
Query: 1880 --FVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENL 1937
+V+HR+ N + + +N + A A +P + E+
Sbjct: 954 MLYVFHRKRNNSRLGNGVLYASVNPEYFSA----------------ADVYVPDEWEVA-- 995
Query: 1938 PAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKE 1997
REK+T+ LG G+FG VYEG A ++ E +VA+KT+ + ++ +E+IEFL E
Sbjct: 996 ----REKITMSRELGQGSFGMVYEGVAKGVVK-DEPETRVAIKTVNEAASMRERIEFLNE 1050
Query: 1998 AHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLL---TLV 2054
A +M +FN ++++ LGV +P +I+ELM GDL +YLR R P+L +L
Sbjct: 1051 ASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLS 1110
Query: 2055 DLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDY 2114
++ + +I+ G YL F+HRDLAARNC+V+ +D+T VKIGDFG+ RDIY+ DY
Sbjct: 1111 KMIQMAGEIADGMAYLNANKFVHRDLAARNCMVA-EDFT----VKIGDFGMTRDIYETDY 1165
Query: 2115 YRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYV 2174
YRK G+GLLPVRWM+PESL DG+FTT SDVWSFG+++WEI TL QPY SN VL +V
Sbjct: 1166 YRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV 1225
Query: 2175 QTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRI 2211
GG L+ P NCPD L+ LM CW P RP+F I
Sbjct: 1226 MEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI 1262
Score = 32.7 bits (73), Expect = 4.3
Identities = 29/129 (22%), Positives = 50/129 (38%), Gaps = 5/129 (3%)
Query: 151 PSYVVKPLHPFTEYIFRVVWIFTAQLQ---LYSPPSPSYRTHPHGVPETAPLIRNIESSS 207
P ++ L P+T+Y V + ++ + S + + PL S+S
Sbjct: 564 PGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNS 623
Query: 208 PDTVEVSWDPPQFPGGPILGYNLRLISKNQKLDAGTQRTSFQFYSTLPNTIYRFSIAAVN 267
+ V W+PP P G + Y +R + Q D R ++ +P Y +
Sbjct: 624 SSQLIVKWNPPSLPNGNLSYYIVRW--QRQPQDGYLYRHNYCSKDKIPIRKYADGTIDIE 681
Query: 268 EVGEGPEAE 276
EV E P+ E
Sbjct: 682 EVTENPKTE 690
Score = 32.3 bits (72), Expect = 5.6
Identities = 38/203 (18%), Positives = 77/203 (37%), Gaps = 24/203 (11%)
Query: 1391 DGDLIYWIITAKDSTQIYQAKKGNGAIVSQVKALRS--RHILAYSSVMQPFPDKAFLSLA 1448
DG + +T T++ +KG + +A + + Y V + F +
Sbjct: 675 DGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPR 734
Query: 1449 SDTVEPTILNATNTSLTIRLPLAKTNLTWYGITSPTPT---YLVYYAEVNDRKNSSDLKY 1505
+ ++ NT+++ R T Y IT P Y + + V++++ +
Sbjct: 735 PERKRRDVMQVANTTMSSR-SRNTTAADTYNITDPEELETEYPFFESRVDNKERT----- 788
Query: 1506 RILEFQDSIALIEDLQPFSTYMIQIAVKNYYSDPLEHLPPGKEIWGKTK--NGVPEAVQL 1563
+I +L+PF+ Y I I N+ ++ L ++ +T G +
Sbjct: 789 ----------VISNLRPFTLYRIDIHSCNHEAEKLG-CSASNFVFARTMPAEGADDIPGP 837
Query: 1564 INTTVRSDTSLIISWRESHKPNG 1586
+ R + S+ + W E PNG
Sbjct: 838 VTWEPRPENSIFLKWPEPENPNG 860
>gi|119395738 insulin receptor isoform Short precursor [Homo sapiens]
Length = 1370
Score = 267 bits (682), Expect = 1e-70
Identities = 138/278 (49%), Positives = 184/278 (66%), Gaps = 9/278 (3%)
Query: 1942 REKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLM 2001
REK+TL LG G+FG VYEG A DI+ G E +VAVKT+ + ++ +E+IEFL EA +M
Sbjct: 1008 REKITLLRELGQGSFGMVYEGNARDIIK-GEAETRVAVKTVNESASLRERIEFLNEASVM 1066
Query: 2002 SKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLL---TLVDLVD 2058
F ++++ LGV +P +++ELM GDL +YLR R P TL +++
Sbjct: 1067 KGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQ 1126
Query: 2059 LCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKR 2118
+ +I+ G YL F+HRDLAARNC+V+ D+T VKIGDFG+ RDIY+ DYYRK
Sbjct: 1127 MAAEIADGMAYLNAKKFVHRDLAARNCMVA-HDFT----VKIGDFGMTRDIYETDYYRKG 1181
Query: 2119 GEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGG 2178
G+GLLPVRWMAPESL DG+FTT SD+WSFG+++WEI +L QPY SN VL +V GG
Sbjct: 1182 GKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGG 1241
Query: 2179 RLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQ 2216
L+ P NCP+ + +LM CW P RPTF I + L+
Sbjct: 1242 YLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLK 1279
Score = 34.3 bits (77), Expect = 1.5
Identities = 21/85 (24%), Positives = 37/85 (43%), Gaps = 2/85 (2%)
Query: 146 KTVSRPSYVVKPLHPFTEYIFRVVWI--FTAQLQLYSPPSPSYRTHPHGVPETAPLIRNI 203
K+ + P ++++ L P+T+Y V + F+ + + Y S + PL
Sbjct: 571 KSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPIS 630
Query: 204 ESSSPDTVEVSWDPPQFPGGPILGY 228
S+S + + W PP P G I Y
Sbjct: 631 VSNSSSQIILKWKPPSDPNGNITHY 655
>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
Length = 1382
Score = 267 bits (682), Expect = 1e-70
Identities = 138/278 (49%), Positives = 184/278 (66%), Gaps = 9/278 (3%)
Query: 1942 REKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLM 2001
REK+TL LG G+FG VYEG A DI+ G E +VAVKT+ + ++ +E+IEFL EA +M
Sbjct: 1020 REKITLLRELGQGSFGMVYEGNARDIIK-GEAETRVAVKTVNESASLRERIEFLNEASVM 1078
Query: 2002 SKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLL---TLVDLVD 2058
F ++++ LGV +P +++ELM GDL +YLR R P TL +++
Sbjct: 1079 KGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQ 1138
Query: 2059 LCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKR 2118
+ +I+ G YL F+HRDLAARNC+V+ D+T VKIGDFG+ RDIY+ DYYRK
Sbjct: 1139 MAAEIADGMAYLNAKKFVHRDLAARNCMVA-HDFT----VKIGDFGMTRDIYETDYYRKG 1193
Query: 2119 GEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGG 2178
G+GLLPVRWMAPESL DG+FTT SD+WSFG+++WEI +L QPY SN VL +V GG
Sbjct: 1194 GKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGG 1253
Query: 2179 RLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQ 2216
L+ P NCP+ + +LM CW P RPTF I + L+
Sbjct: 1254 YLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLK 1291
Score = 34.3 bits (77), Expect = 1.5
Identities = 21/85 (24%), Positives = 37/85 (43%), Gaps = 2/85 (2%)
Query: 146 KTVSRPSYVVKPLHPFTEYIFRVVWI--FTAQLQLYSPPSPSYRTHPHGVPETAPLIRNI 203
K+ + P ++++ L P+T+Y V + F+ + + Y S + PL
Sbjct: 571 KSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPIS 630
Query: 204 ESSSPDTVEVSWDPPQFPGGPILGY 228
S+S + + W PP P G I Y
Sbjct: 631 VSNSSSQIILKWKPPSDPNGNITHY 655
>gi|31657140 insulin receptor-related receptor precursor [Homo
sapiens]
Length = 1297
Score = 258 bits (658), Expect = 6e-68
Identities = 143/294 (48%), Positives = 188/294 (63%), Gaps = 11/294 (3%)
Query: 1941 PREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHL 2000
PRE++++ LG G+FG VYEG A L G VA+KT+ + ++ +E IEFLKEA +
Sbjct: 975 PREQISIIRELGQGSFGMVYEGLARG-LEAGEESTPVALKTVNELASPRECIEFLKEASV 1033
Query: 2001 MSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLL---TLVDLV 2057
M F ++++ LGV +P +I+ELM GDL ++LR R P L L +++
Sbjct: 1034 MKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQPALGEMI 1093
Query: 2058 DLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRK 2117
+ +I+ G YL F+HRDLAARNC+VS +D+T VKIGDFG+ RD+Y+ DYYRK
Sbjct: 1094 QMAGEIADGMAYLAANKFVHRDLAARNCMVS-QDFT----VKIGDFGMTRDVYETDYYRK 1148
Query: 2118 RGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTG 2177
G+GLLPVRWMAPESL DGIFTT SDVWSFG+++WEI+TL QPY SN VL +V G
Sbjct: 1149 GGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDG 1208
Query: 2178 GRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQ--LFRNFFLNSIYKS 2229
G LE CP L LM++CW P RP+F I D +Q L +F L S Y S
Sbjct: 1209 GVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQEELRPSFRLLSFYYS 1262
>gi|208879423 leukocyte receptor tyrosine kinase isoform 3 precursor
[Homo sapiens]
Length = 734
Score = 256 bits (654), Expect = 2e-67
Identities = 123/274 (44%), Positives = 184/274 (67%), Gaps = 9/274 (3%)
Query: 1978 AVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTY 2037
+ +TL + + Q++++FL EA ++SKF H NI++ +G+ L P+ I+LELM GGD+ ++
Sbjct: 412 SAQTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSF 471
Query: 2038 LRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRI 2097
LR +R L + DL+ L DI++GC YLE HFIHRD+AARNCL+S + R+
Sbjct: 472 LRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPS--RV 529
Query: 2098 VKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTL 2157
KIGDFG+ARDIY+ YYR+ LLPV+WM PE+ ++GIFT+++D WSFG+L+WEI +L
Sbjct: 530 AKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSL 589
Query: 2158 GHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQ- 2216
G+ PYP +N +VL++V GGR++PPR CP ++ +MTQCW EP+ RP+F I ++LQ
Sbjct: 590 GYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQY 649
Query: 2217 ------LFRNFFLNSIYKSRDEANNSGVINESFE 2244
+ + + + +E SG+ N S E
Sbjct: 650 CTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLE 683
>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
Length = 1072
Score = 234 bits (596), Expect = 1e-60
Identities = 127/297 (42%), Positives = 176/297 (59%), Gaps = 29/297 (9%)
Query: 1940 FPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAH 1999
FPR+ L L LG G FG+V + TA + G +G VAVK LK+ ++ E + L E +
Sbjct: 719 FPRKNLVLGKTLGEGEFGKVVKATAFHLKG-RAGYTTVAVKMLKENASPSELRDLLSEFN 777
Query: 2000 LMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGP---------- 2049
++ + NHP+++K G C + P +I+E + G L +LR++R GP
Sbjct: 778 VLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKV---GPGYLGSGGSRN 834
Query: 2050 ----------LLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVK 2099
LT+ DL+ IS+G YL M +HRDLAARN LV+ R +K
Sbjct: 835 SSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVA-----EGRKMK 889
Query: 2100 IGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGH 2159
I DFGL+RD+Y+ D Y KR +G +PV+WMA ESL D I+TTQSDVWSFG+L+WEI+TLG
Sbjct: 890 ISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGG 949
Query: 2160 QPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQ 2216
PYP + N ++TG R+E P NC ++++ LM QCW QEPD+RP F I L+
Sbjct: 950 NPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLE 1006
>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
Length = 1114
Score = 234 bits (596), Expect = 1e-60
Identities = 127/297 (42%), Positives = 176/297 (59%), Gaps = 29/297 (9%)
Query: 1940 FPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAH 1999
FPR+ L L LG G FG+V + TA + G +G VAVK LK+ ++ E + L E +
Sbjct: 719 FPRKNLVLGKTLGEGEFGKVVKATAFHLKG-RAGYTTVAVKMLKENASPSELRDLLSEFN 777
Query: 2000 LMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGP---------- 2049
++ + NHP+++K G C + P +I+E + G L +LR++R GP
Sbjct: 778 VLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKV---GPGYLGSGGSRN 834
Query: 2050 ----------LLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVK 2099
LT+ DL+ IS+G YL M +HRDLAARN LV+ R +K
Sbjct: 835 SSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVA-----EGRKMK 889
Query: 2100 IGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGH 2159
I DFGL+RD+Y+ D Y KR +G +PV+WMA ESL D I+TTQSDVWSFG+L+WEI+TLG
Sbjct: 890 ISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGG 949
Query: 2160 QPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQ 2216
PYP + N ++TG R+E P NC ++++ LM QCW QEPD+RP F I L+
Sbjct: 950 NPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLE 1006
>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
Length = 822
Score = 223 bits (569), Expect = 1e-57
Identities = 116/277 (41%), Positives = 170/277 (61%), Gaps = 19/277 (6%)
Query: 1943 EKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMS 2002
E + L LLG G FGEVY+GT D + VAVKT K+ + KI+FL+EA ++
Sbjct: 561 EDVILGELLGKGNFGEVYKGTLKD-------KTSVAVKTCKEDLPQELKIKFLQEAKILK 613
Query: 2003 KFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVD 2062
+++HPNI+K +GVC +P YII+EL+ GGD LT+LR+ + L L LV +D
Sbjct: 614 QYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDE------LKLKQLVKFSLD 667
Query: 2063 ISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGL 2122
+ G +YLE + IHRDLAARNCLV + ++KI DFG++R Y G
Sbjct: 668 AAAGMLYLESKNCIHRDLAARNCLVGENN-----VLKISDFGMSRQ-EDGGVYSSSGLKQ 721
Query: 2123 LPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEP 2182
+P++W APE+L G ++++SDVWSFGIL+WE +LG PYP +N V+ G R+
Sbjct: 722 IPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSA 781
Query: 2183 PRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFR 2219
P++CP+D+ +M +CW +P+ RP F +Q +L + +
Sbjct: 782 PQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIK 818
>gi|66932918 MER receptor tyrosine kinase precursor [Homo sapiens]
Length = 999
Score = 222 bits (565), Expect = 4e-57
Identities = 134/334 (40%), Positives = 193/334 (57%), Gaps = 24/334 (7%)
Query: 1925 IHTLPTQEEIENL---PAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKT 1981
+H+L EE++N R L L +LG G FG V EG G +KVAVKT
Sbjct: 564 LHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTS---LKVAVKT 620
Query: 1982 LKKGSTDQEKIE-FLKEAHLMSKFNHPNILKQLGVCLLNEPQ-----YIILELMEGGDLL 2035
+K ++ Q +IE FL EA M F+HPN+++ LGVC+ Q +IL M+ GDL
Sbjct: 621 MKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLH 680
Query: 2036 TYLRKARMATFYGPL-LTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTS 2094
TYL +R+ T GP + L L+ VDI+ G YL +F+HRDLAARNC++ D T
Sbjct: 681 TYLLYSRLET--GPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLR-DDMT- 736
Query: 2095 PRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEI 2154
V + DFGL++ IY DYYR+ +PV+W+A ESL D ++T++SDVW+FG+ +WEI
Sbjct: 737 ---VCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEI 793
Query: 2155 LTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQ 2214
T G PYP N ++ +Y+ G RL+ P +C D+L+ +M CW +P RPTF ++ Q
Sbjct: 794 ATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQ 853
Query: 2215 LQLFRNFFLNSIYKSRDEANNSGVINESFEGEDG 2248
L+ L S+ R++A+ V + E +G
Sbjct: 854 LEK----LLESLPDVRNQADVIYVNTQLLESSEG 883
>gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens]
Length = 885
Score = 220 bits (561), Expect = 1e-56
Identities = 167/542 (30%), Positives = 257/542 (47%), Gaps = 59/542 (10%)
Query: 1704 TSCSQGPAYVCNITNLQPYTSYNVRVVVVYKTGENSTSLPESFKTKAGVPNKP--GIPKL 1761
TS + P + + +L P+T Y++RV G +S + +T GVP P I
Sbjct: 284 TSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISAT 343
Query: 1762 LEGSKNSIQWE--KAEDNGCRITYYILEIRKSTSNNLQNQNLRWKMTF----NGSCSSVC 1815
GS+ + W+ +A G + Y + + T L + LR ++T +GS S++
Sbjct: 344 RNGSQAFVHWQEPRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLT 403
Query: 1816 TWKSKNLKGIFQFRVVAANNLGFGEYSGISENIILVGDDFWIPETS-----------FIL 1864
V A G G +S + V + W P ++L
Sbjct: 404 VC------------VAAYTAAGDGPWS------LPVPLEAWRPVKEPSTPAFSWPWWYVL 445
Query: 1865 TIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYA 1924
V V I F+ HRR K + + + E EL +
Sbjct: 446 LGAVVAAACVLILALFLVHRRKKETRYGEVFEPTV--ERGELVVRYRVRKSYSRRTTEAT 503
Query: 1925 IHTLPTQEEIENL---PAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKT 1981
+++L EE++ R K+ L LG G FG V EG L +KVAVKT
Sbjct: 504 LNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQ----LNQDDSILKVAVKT 559
Query: 1982 LKKGSTDQEKIE-FLKEAHLMSKFNHPNILKQLGVCLLNEPQ------YIILELMEGGDL 2034
+K + ++E FL EA M +F+HPN+++ +GVC + +IL M+ GDL
Sbjct: 560 MKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDL 619
Query: 2035 LTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTS 2094
++L +R+ L T + LV DI+ G YL FIHRDLAARNC+++
Sbjct: 620 HSFLLYSRLGDQPVYLPTQM-LVKFMADIASGMEYLSTKRFIHRDLAARNCMLNEN---- 674
Query: 2095 PRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEI 2154
V + DFGL++ IY DYYR+ +PV+W+A ESL D ++T++SDVWSFG+ +WEI
Sbjct: 675 -MSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEI 733
Query: 2155 LTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQ 2214
T G PYP N ++ +Y++ G RL+ P +C D L+ LM++CW P RP+F +++
Sbjct: 734 ATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELRED 793
Query: 2215 LQ 2216
L+
Sbjct: 794 LE 795
>gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens]
Length = 694
Score = 220 bits (560), Expect = 1e-56
Identities = 118/277 (42%), Positives = 167/277 (60%), Gaps = 17/277 (6%)
Query: 1943 EKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMS 2002
E L L +G G FGEV+ G + + VAVK+ ++ K +FL+EA ++
Sbjct: 431 EDLVLGEQIGRGNFGEVFSGR------LRADNTLVAVKSCRETLPPDLKAKFLQEARILK 484
Query: 2003 KFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVD 2062
+++HPNI++ +GVC +P YI++EL++GGD LT+LR G L + L+ + D
Sbjct: 485 QYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTE------GARLRVKTLLQMVGD 538
Query: 2063 ISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGL 2122
+ G YLE IHRDLAARNCLV+ K+ ++KI DFG++R+ Y G
Sbjct: 539 AAAGMEYLESKCCIHRDLAARNCLVTEKN-----VLKISDFGMSREEADGVYAASGGLRQ 593
Query: 2123 LPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEP 2182
+PV+W APE+L G ++++SDVWSFGIL+WE +LG PYP SN +V+ GGRL
Sbjct: 594 VPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPC 653
Query: 2183 PRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFR 2219
P CPD ++ LM QCWA EP QRP+F I +LQ R
Sbjct: 654 PELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIR 690
>gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens]
Length = 752
Score = 220 bits (560), Expect = 1e-56
Identities = 118/277 (42%), Positives = 167/277 (60%), Gaps = 17/277 (6%)
Query: 1943 EKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMS 2002
E L L +G G FGEV+ G + + VAVK+ ++ K +FL+EA ++
Sbjct: 489 EDLVLGEQIGRGNFGEVFSGR------LRADNTLVAVKSCRETLPPDLKAKFLQEARILK 542
Query: 2003 KFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVD 2062
+++HPNI++ +GVC +P YI++EL++GGD LT+LR G L + L+ + D
Sbjct: 543 QYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTE------GARLRVKTLLQMVGD 596
Query: 2063 ISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGL 2122
+ G YLE IHRDLAARNCLV+ K+ ++KI DFG++R+ Y G
Sbjct: 597 AAAGMEYLESKCCIHRDLAARNCLVTEKN-----VLKISDFGMSREEADGVYAASGGLRQ 651
Query: 2123 LPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEP 2182
+PV+W APE+L G ++++SDVWSFGIL+WE +LG PYP SN +V+ GGRL
Sbjct: 652 VPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPC 711
Query: 2183 PRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFR 2219
P CPD ++ LM QCWA EP QRP+F I +LQ R
Sbjct: 712 PELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIR 748
>gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]
Length = 764
Score = 220 bits (560), Expect = 1e-56
Identities = 118/277 (42%), Positives = 167/277 (60%), Gaps = 17/277 (6%)
Query: 1943 EKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMS 2002
E L L +G G FGEV+ G + + VAVK+ ++ K +FL+EA ++
Sbjct: 501 EDLVLGEQIGRGNFGEVFSGR------LRADNTLVAVKSCRETLPPDLKAKFLQEARILK 554
Query: 2003 KFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVD 2062
+++HPNI++ +GVC +P YI++EL++GGD LT+LR G L + L+ + D
Sbjct: 555 QYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTE------GARLRVKTLLQMVGD 608
Query: 2063 ISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGL 2122
+ G YLE IHRDLAARNCLV+ K+ ++KI DFG++R+ Y G
Sbjct: 609 AAAGMEYLESKCCIHRDLAARNCLVTEKN-----VLKISDFGMSREEADGVYAASGGLRQ 663
Query: 2123 LPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEP 2182
+PV+W APE+L G ++++SDVWSFGIL+WE +LG PYP SN +V+ GGRL
Sbjct: 664 VPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPC 723
Query: 2183 PRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFR 2219
P CPD ++ LM QCWA EP QRP+F I +LQ R
Sbjct: 724 PELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIR 760
>gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]
Length = 822
Score = 220 bits (560), Expect = 1e-56
Identities = 118/277 (42%), Positives = 167/277 (60%), Gaps = 17/277 (6%)
Query: 1943 EKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMS 2002
E L L +G G FGEV+ G + + VAVK+ ++ K +FL+EA ++
Sbjct: 559 EDLVLGEQIGRGNFGEVFSGR------LRADNTLVAVKSCRETLPPDLKAKFLQEARILK 612
Query: 2003 KFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVD 2062
+++HPNI++ +GVC +P YI++EL++GGD LT+LR G L + L+ + D
Sbjct: 613 QYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTE------GARLRVKTLLQMVGD 666
Query: 2063 ISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGL 2122
+ G YLE IHRDLAARNCLV+ K+ ++KI DFG++R+ Y G
Sbjct: 667 AAAGMEYLESKCCIHRDLAARNCLVTEKN-----VLKISDFGMSREEADGVYAASGGLRQ 721
Query: 2123 LPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEP 2182
+PV+W APE+L G ++++SDVWSFGIL+WE +LG PYP SN +V+ GGRL
Sbjct: 722 VPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPC 781
Query: 2183 PRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFR 2219
P CPD ++ LM QCWA EP QRP+F I +LQ R
Sbjct: 782 PELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIR 818
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 219 bits (558), Expect = 2e-56
Identities = 162/501 (32%), Positives = 237/501 (47%), Gaps = 73/501 (14%)
Query: 1760 KLLEGSKNSIQWEK-AEDNGCRI----TYYILEIRKSTSNNLQNQNLRWKMTFNGSCSSV 1814
K+ ++ IQW K E NG ++ T Y+ ++ + +N + V
Sbjct: 276 KVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKE------------LEV 323
Query: 1815 CTWKSKNLKGIFQFRVVAANNLGFGEYSG----ISENIILVGDDFWIPETSFILTIIVGI 1870
+ + + ++ +A N++GF +S + LV D + IL+ VG
Sbjct: 324 LSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGF 383
Query: 1871 FLVVTIPLTFVWHRR--------------------LKNQKSAKEGVTVLINEDKELAELR 1910
FL + + R LK Q S + ++ N L +
Sbjct: 384 FLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTP--LVRIA 441
Query: 1911 GLAAGVGLANACYAIHTLPTQEEIENLPAFP-----REKLTLRLLLGSGAFGEVYEGTAV 1965
L++G G TL E+E LPA P R +LTL LG G FG+V A+
Sbjct: 442 RLSSGEG--------PTLANVSELE-LPADPKWELSRARLTLGKPLGEGCFGQVVMAEAI 492
Query: 1966 DI-LGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFN-HPNILKQLGVCLLNEPQY 2023
I + + VAVK LK +TD++ + + E +M H NI+ LG C P Y
Sbjct: 493 GIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLY 552
Query: 2024 IILELMEGGDLLTYLRKAR-------MATFYGP--LLTLVDLVDLCVDISKGCVYLERMH 2074
+++E G+L +LR R T P LT DLV +++G YL
Sbjct: 553 VLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQK 612
Query: 2075 FIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLM 2134
IHRDLAARN LV T ++KI DFGLARD++ DYY+K G LPV+WMAPE+L
Sbjct: 613 CIHRDLAARNVLV-----TEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALF 667
Query: 2135 DGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLM 2194
D ++T QSDVWSFG+L+WEI TLG PYP ++ ++ G R++ P NC DL+ +M
Sbjct: 668 DRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIM 727
Query: 2195 TQCWAQEPDQRPTFHRIQDQL 2215
+CW P QRPTF ++ + L
Sbjct: 728 RECWHAAPSQRPTFKQLVEDL 748
>gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens]
Length = 894
Score = 219 bits (557), Expect = 3e-56
Identities = 167/546 (30%), Positives = 263/546 (48%), Gaps = 58/546 (10%)
Query: 1704 TSCSQGPAYVCNITNLQPYTSYNVRVVVVYKTGENSTSLPESFKTKAGVPNKP--GIPKL 1761
TS + P + + +L P+T Y++RV G +S + +T GVP P I
Sbjct: 284 TSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISAT 343
Query: 1762 LEGSKNSIQWE--KAEDNGCRITYYILEIRKSTSNNLQNQNLRWKMTF----NGSCSSVC 1815
GS+ + W+ +A G + Y + + T L + LR ++T +GS S++
Sbjct: 344 RNGSQAFVHWQEPRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLT 403
Query: 1816 TWKSKNLKGIFQFRVVAANNLGFGEYS----------GISENIILVGDDFWIPETSF--- 1862
V A G G +S G ++ + + + P S+
Sbjct: 404 VC------------VAAYTAAGDGPWSLPVPLEAWRPGQAQPVHQLVKEPSTPAFSWPWW 451
Query: 1863 --ILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLAN 1920
+L +V V+ + L F+ HRR K + + + E EL +
Sbjct: 452 YVLLGAVVAAACVLILAL-FLVHRRKKETRYGEVFEPTV--ERGELVVRYRVRKSYSRRT 508
Query: 1921 ACYAIHTLPTQEEIENL---PAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKV 1977
+++L EE++ R K+ L LG G FG V EG L +KV
Sbjct: 509 TEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQ----LNQDDSILKV 564
Query: 1978 AVKTLKKGSTDQEKIE-FLKEAHLMSKFNHPNILKQLGVCLLNEPQ------YIILELME 2030
AVKT+K + ++E FL EA M +F+HPN+++ +GVC + +IL M+
Sbjct: 565 AVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMK 624
Query: 2031 GGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVK 2090
GDL ++L +R+ L T + LV DI+ G YL FIHRDLAARNC+++
Sbjct: 625 HGDLHSFLLYSRLGDQPVYLPTQM-LVKFMADIASGMEYLSTKRFIHRDLAARNCMLNEN 683
Query: 2091 DYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGIL 2150
V + DFGL++ IY DYYR+ +PV+W+A ESL D ++T++SDVWSFG+
Sbjct: 684 -----MSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVT 738
Query: 2151 IWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHR 2210
+WEI T G PYP N ++ +Y++ G RL+ P +C D L+ LM++CW P RP+F
Sbjct: 739 MWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTE 798
Query: 2211 IQDQLQ 2216
+++ L+
Sbjct: 799 LREDLE 804
Score = 32.0 bits (71), Expect = 7.3
Identities = 38/147 (25%), Positives = 48/147 (32%), Gaps = 34/147 (23%)
Query: 549 GSSSQLHPLP---------GRPQELSVLFGSHQALVQWKPPALAIGANVILISDIIELFE 599
G SS H LP G P+ +S QA V W+ P + ++
Sbjct: 316 GPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPLQGTLL---------- 365
Query: 600 LGPSAWQNWTYEVKVSTQDPPEVTHIFLNISGTMLNVPELQ---SAMKYKVSVRASSPKR 656
Y + QD PEV ++I ELQ S V V A +
Sbjct: 366 ---------GYRLAYQGQDTPEV---LMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAG 413
Query: 657 PGPWSEPSVGTTLVPASEPPFIMAVKE 683
GPWS P P P VKE
Sbjct: 414 DGPWSLPVPLEAWRPGQAQPVHQLVKE 440
>gi|222144244 fibroblast growth factor receptor 2 isoform 9 precursor
[Homo sapiens]
Length = 680
Score = 218 bits (555), Expect = 6e-56
Identities = 125/298 (41%), Positives = 166/298 (55%), Gaps = 16/298 (5%)
Query: 1940 FPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGE-IKVAVKTLKKGSTDQEKIEFLKEA 1998
FPR+KLTL LG G FG+V AV I E + VAVK LK +T+++ + + E
Sbjct: 388 FPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEM 447
Query: 1999 HLMSKFN-HPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKAR---MATFYG------ 2048
+M H NI+ LG C + P Y+I+E G+L YLR R M Y
Sbjct: 448 EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPE 507
Query: 2049 PLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARD 2108
+T DLV +++G YL IHRDLAARN LV T ++KI DFGLARD
Sbjct: 508 EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLV-----TENNVMKIADFGLARD 562
Query: 2109 IYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNL 2168
I DYY+K G LPV+WMAPE+L D ++T QSDVWSFG+L+WEI TLG PYP
Sbjct: 563 INNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVE 622
Query: 2169 DVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSI 2226
++ ++ G R++ P NC ++L+ +M CW P QRPTF ++ + L N I
Sbjct: 623 ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEI 680
>gi|222144231 fibroblast growth factor receptor 2 isoform 3 precursor
[Homo sapiens]
Length = 769
Score = 218 bits (555), Expect = 6e-56
Identities = 125/298 (41%), Positives = 166/298 (55%), Gaps = 16/298 (5%)
Query: 1940 FPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGE-IKVAVKTLKKGSTDQEKIEFLKEA 1998
FPR+KLTL LG G FG+V AV I E + VAVK LK +T+++ + + E
Sbjct: 477 FPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEM 536
Query: 1999 HLMSKFN-HPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKAR---MATFYG------ 2048
+M H NI+ LG C + P Y+I+E G+L YLR R M Y
Sbjct: 537 EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPE 596
Query: 2049 PLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARD 2108
+T DLV +++G YL IHRDLAARN LV T ++KI DFGLARD
Sbjct: 597 EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLV-----TENNVMKIADFGLARD 651
Query: 2109 IYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNL 2168
I DYY+K G LPV+WMAPE+L D ++T QSDVWSFG+L+WEI TLG PYP
Sbjct: 652 INNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVE 711
Query: 2169 DVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSI 2226
++ ++ G R++ P NC ++L+ +M CW P QRPTF ++ + L N I
Sbjct: 712 ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEI 769
>gi|222144241 fibroblast growth factor receptor 2 isoform 8 precursor
[Homo sapiens]
Length = 704
Score = 218 bits (555), Expect = 6e-56
Identities = 125/299 (41%), Positives = 166/299 (55%), Gaps = 16/299 (5%)
Query: 1940 FPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGE-IKVAVKTLKKGSTDQEKIEFLKEA 1998
FPR+KLTL LG G FG+V AV I E + VAVK LK +T+++ + + E
Sbjct: 359 FPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEM 418
Query: 1999 HLMSKFN-HPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKAR---MATFYG------ 2048
+M H NI+ LG C + P Y+I+E G+L YLR R M Y
Sbjct: 419 EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPE 478
Query: 2049 PLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARD 2108
+T DLV +++G YL IHRDLAARN LV T ++KI DFGLARD
Sbjct: 479 EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLV-----TENNVMKIADFGLARD 533
Query: 2109 IYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNL 2168
I DYY+K G LPV+WMAPE+L D ++T QSDVWSFG+L+WEI TLG PYP
Sbjct: 534 INNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVE 593
Query: 2169 DVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIY 2227
++ ++ G R++ P NC ++L+ +M CW P QRPTF ++ + L N Y
Sbjct: 594 ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEY 652
>gi|222144239 fibroblast growth factor receptor 2 isoform 7 precursor
[Homo sapiens]
Length = 705
Score = 218 bits (555), Expect = 6e-56
Identities = 125/299 (41%), Positives = 166/299 (55%), Gaps = 16/299 (5%)
Query: 1940 FPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGE-IKVAVKTLKKGSTDQEKIEFLKEA 1998
FPR+KLTL LG G FG+V AV I E + VAVK LK +T+++ + + E
Sbjct: 360 FPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEM 419
Query: 1999 HLMSKFN-HPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKAR---MATFYG------ 2048
+M H NI+ LG C + P Y+I+E G+L YLR R M Y
Sbjct: 420 EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPE 479
Query: 2049 PLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARD 2108
+T DLV +++G YL IHRDLAARN LV T ++KI DFGLARD
Sbjct: 480 EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLV-----TENNVMKIADFGLARD 534
Query: 2109 IYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNL 2168
I DYY+K G LPV+WMAPE+L D ++T QSDVWSFG+L+WEI TLG PYP
Sbjct: 535 INNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVE 594
Query: 2169 DVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIY 2227
++ ++ G R++ P NC ++L+ +M CW P QRPTF ++ + L N Y
Sbjct: 595 ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEY 653
>gi|222144237 fibroblast growth factor receptor 2 isoform 6 precursor
[Homo sapiens]
Length = 706
Score = 218 bits (555), Expect = 6e-56
Identities = 125/299 (41%), Positives = 166/299 (55%), Gaps = 16/299 (5%)
Query: 1940 FPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGE-IKVAVKTLKKGSTDQEKIEFLKEA 1998
FPR+KLTL LG G FG+V AV I E + VAVK LK +T+++ + + E
Sbjct: 361 FPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEM 420
Query: 1999 HLMSKFN-HPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKAR---MATFYG------ 2048
+M H NI+ LG C + P Y+I+E G+L YLR R M Y
Sbjct: 421 EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPE 480
Query: 2049 PLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARD 2108
+T DLV +++G YL IHRDLAARN LV T ++KI DFGLARD
Sbjct: 481 EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLV-----TENNVMKIADFGLARD 535
Query: 2109 IYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNL 2168
I DYY+K G LPV+WMAPE+L D ++T QSDVWSFG+L+WEI TLG PYP
Sbjct: 536 INNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVE 595
Query: 2169 DVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIY 2227
++ ++ G R++ P NC ++L+ +M CW P QRPTF ++ + L N Y
Sbjct: 596 ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEY 654
>gi|222144233 fibroblast growth factor receptor 2 isoform 4 precursor
[Homo sapiens]
Length = 709
Score = 218 bits (555), Expect = 6e-56
Identities = 125/299 (41%), Positives = 166/299 (55%), Gaps = 16/299 (5%)
Query: 1940 FPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGE-IKVAVKTLKKGSTDQEKIEFLKEA 1998
FPR+KLTL LG G FG+V AV I E + VAVK LK +T+++ + + E
Sbjct: 364 FPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEM 423
Query: 1999 HLMSKFN-HPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKAR---MATFYG------ 2048
+M H NI+ LG C + P Y+I+E G+L YLR R M Y
Sbjct: 424 EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPE 483
Query: 2049 PLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARD 2108
+T DLV +++G YL IHRDLAARN LV T ++KI DFGLARD
Sbjct: 484 EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLV-----TENNVMKIADFGLARD 538
Query: 2109 IYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNL 2168
I DYY+K G LPV+WMAPE+L D ++T QSDVWSFG+L+WEI TLG PYP
Sbjct: 539 INNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVE 598
Query: 2169 DVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIY 2227
++ ++ G R++ P NC ++L+ +M CW P QRPTF ++ + L N Y
Sbjct: 599 ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEY 657
>gi|221316639 fibroblast growth factor receptor 2 isoform 1 precursor
[Homo sapiens]
Length = 821
Score = 218 bits (555), Expect = 6e-56
Identities = 125/299 (41%), Positives = 166/299 (55%), Gaps = 16/299 (5%)
Query: 1940 FPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGE-IKVAVKTLKKGSTDQEKIEFLKEA 1998
FPR+KLTL LG G FG+V AV I E + VAVK LK +T+++ + + E
Sbjct: 476 FPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEM 535
Query: 1999 HLMSKFN-HPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKAR---MATFYG------ 2048
+M H NI+ LG C + P Y+I+E G+L YLR R M Y
Sbjct: 536 EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPE 595
Query: 2049 PLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARD 2108
+T DLV +++G YL IHRDLAARN LV T ++KI DFGLARD
Sbjct: 596 EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLV-----TENNVMKIADFGLARD 650
Query: 2109 IYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNL 2168
I DYY+K G LPV+WMAPE+L D ++T QSDVWSFG+L+WEI TLG PYP
Sbjct: 651 INNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVE 710
Query: 2169 DVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIY 2227
++ ++ G R++ P NC ++L+ +M CW P QRPTF ++ + L N Y
Sbjct: 711 ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEY 769
>gi|221316638 fibroblast growth factor receptor 2 isoform 2 precursor
[Homo sapiens]
Length = 822
Score = 218 bits (555), Expect = 6e-56
Identities = 125/299 (41%), Positives = 166/299 (55%), Gaps = 16/299 (5%)
Query: 1940 FPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGE-IKVAVKTLKKGSTDQEKIEFLKEA 1998
FPR+KLTL LG G FG+V AV I E + VAVK LK +T+++ + + E
Sbjct: 477 FPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEM 536
Query: 1999 HLMSKFN-HPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKAR---MATFYG------ 2048
+M H NI+ LG C + P Y+I+E G+L YLR R M Y
Sbjct: 537 EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPE 596
Query: 2049 PLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARD 2108
+T DLV +++G YL IHRDLAARN LV T ++KI DFGLARD
Sbjct: 597 EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLV-----TENNVMKIADFGLARD 651
Query: 2109 IYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNL 2168
I DYY+K G LPV+WMAPE+L D ++T QSDVWSFG+L+WEI TLG PYP
Sbjct: 652 INNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVE 711
Query: 2169 DVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIY 2227
++ ++ G R++ P NC ++L+ +M CW P QRPTF ++ + L N Y
Sbjct: 712 ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEY 770
>gi|254028242 fibroblast growth factor receptor 3 isoform 3 precursor
[Homo sapiens]
Length = 808
Score = 218 bits (554), Expect = 7e-56
Identities = 135/346 (39%), Positives = 185/346 (53%), Gaps = 32/346 (9%)
Query: 1886 LKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFP---- 1941
LK Q S + ++ N L + L++G G TL E+E LPA P
Sbjct: 421 LKRQVSLESNASMSSNTP--LVRIARLSSGEG--------PTLANVSELE-LPADPKWEL 469
Query: 1942 -REKLTLRLLLGSGAFGEVYEGTAVDI-LGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAH 1999
R +LTL LG G FG+V A+ I + + VAVK LK +TD++ + + E
Sbjct: 470 SRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEME 529
Query: 2000 LMSKFN-HPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKAR-------MATFYGP-- 2049
+M H NI+ LG C P Y+++E G+L +LR R T P
Sbjct: 530 MMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEE 589
Query: 2050 LLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDI 2109
LT DLV +++G YL IHRDLAARN LV T ++KI DFGLARD+
Sbjct: 590 QLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLV-----TEDNVMKIADFGLARDV 644
Query: 2110 YKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLD 2169
+ DYY+K G LPV+WMAPE+L D ++T QSDVWSFG+L+WEI TLG PYP +
Sbjct: 645 HNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEE 704
Query: 2170 VLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQL 2215
+ ++ G R++ P NC DL+ +M +CW P QRPTF ++ + L
Sbjct: 705 LFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL 750
>gi|32967311 ephrin receptor EphA2 [Homo sapiens]
Length = 976
Score = 217 bits (552), Expect = 1e-55
Identities = 164/509 (32%), Positives = 258/509 (50%), Gaps = 59/509 (11%)
Query: 1716 ITNLQPYTSYNVRVVVVYKTGENSTSLPESFKTKAGVPNKPGIPKL-LEGSKN---SIQW 1771
+++L+P+ +Y V + G + SF+T + N+ PK+ LEG S+ W
Sbjct: 399 VSDLEPHMNYTFTVEA--RNGVSGLVTSRSFRTASVSINQTEPPKVRLEGRSTTSLSVSW 456
Query: 1772 EKAEDNGCRITYYILEIRKSTSNNLQNQNLRWKMTFNGSCSSVCTWKSKNLKGIFQFRVV 1831
R+ Y + RK +N + N+R F+ + + + + +V
Sbjct: 457 SIPPPQQSRVWKYEVTYRKKGDSN--SYNVRRTEGFSVTLDDLAPDTT------YLVQVQ 508
Query: 1832 AANNLGFGEYSGISENIILVGDDFWIPETSFILTIIVGI-----FLVVTIPLTFVWHRRL 1886
A G G S + E L PE S L +I G+ L+V + F HRR
Sbjct: 509 ALTQEGQGAGSKVHEFQTLS------PEGSGNLAVIGGVAVGVVLLLVLAGVGFFIHRRR 562
Query: 1887 KNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTL--PTQEEIENLPAFPREK 1944
KNQ++ + V ++ ++L L+ HT P Q ++
Sbjct: 563 KNQRARQSPEDVYFSKSEQLKPLKTYVDP----------HTYEDPNQAVLKFTTEIHPSC 612
Query: 1945 LTLRLLLGSGAFGEVYEGTAVDILGVGSG--EIKVAVKTLKKGSTDQEKIEFLKEAHLMS 2002
+T + ++G+G FGEVY+G +L SG E+ VA+KTLK G T++++++FL EA +M
Sbjct: 613 VTRQKVIGAGEFGEVYKG----MLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMG 668
Query: 2003 KFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVD 2062
+F+H NI++ GV +P II E ME G L +LR+ +++ LV +
Sbjct: 669 QFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGE------FSVLQLVGMLRG 722
Query: 2063 ISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKND---YYRKRG 2119
I+ G YL M+++HRDLAARN LV+ S + K+ DFGL+R + ++D Y G
Sbjct: 723 IAAGMKYLANMNYVHRDLAARNILVN-----SNLVCKVSDFGLSR-VLEDDPEATYTTSG 776
Query: 2120 EGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGR 2179
G +P+RW APE++ FT+ SDVWSFGI++WE++T G +PY SN +V+ + G R
Sbjct: 777 -GKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFR 835
Query: 2180 LEPPRNCPDDLWNLMTQCWAQEPDQRPTF 2208
L P +CP ++ LM QCW QE +RP F
Sbjct: 836 LPTPMDCPSAIYQLMMQCWQQERARRPKF 864
Score = 34.7 bits (78), Expect = 1.1
Identities = 32/129 (24%), Positives = 50/129 (38%), Gaps = 8/129 (6%)
Query: 148 VSRPSYVVKPLHPFTEYIFRVVWIFTAQLQLYS-PPSPSYRTHPHGVPETAPLIRNIESS 206
++R S V L P Y F V A+ + S S+RT + +T P +E
Sbjct: 392 LTRTSVTVSDLEPHMNYTFTV----EARNGVSGLVTSRSFRTASVSINQTEPPKVRLEGR 447
Query: 207 SPDTVEVSWDPPQFPGGPILGYNLRLISKNQKLDAGTQRT---SFQFYSTLPNTIYRFSI 263
S ++ VSW P + Y + K +RT S P+T Y +
Sbjct: 448 STTSLSVSWSIPPPQQSRVWKYEVTYRKKGDSNSYNVRRTEGFSVTLDDLAPDTTYLVQV 507
Query: 264 AAVNEVGEG 272
A+ + G+G
Sbjct: 508 QALTQEGQG 516
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 93,423,373
Number of Sequences: 37866
Number of extensions: 4407884
Number of successful extensions: 14794
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 289
Number of HSP's successfully gapped in prelim test: 563
Number of HSP's that attempted gapping in prelim test: 10158
Number of HSP's gapped (non-prelim): 3287
length of query: 2347
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2228
effective length of database: 13,741,464
effective search space: 30615981792
effective search space used: 30615981792
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.