Guide to the Human Genome
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Search of human proteins with 19924165

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo
sapiens]
         (2347 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]  4787   0.0  
gi|29029632 anaplastic lymphoma kinase [Homo sapiens]                 301   4e-81
gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precurs...   285   3e-76
gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precurs...   285   3e-76
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo...   270   2e-71
gi|119395738 insulin receptor isoform Short precursor [Homo sapi...   267   1e-70
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]   267   1e-70
gi|31657140 insulin receptor-related receptor precursor [Homo sa...   258   6e-68
gi|208879423 leukocyte receptor tyrosine kinase isoform 3 precur...   256   2e-67
gi|10862701 ret proto-oncogene isoform c [Homo sapiens]               234   1e-60
gi|10862703 ret proto-oncogene isoform a [Homo sapiens]               234   1e-60
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]     223   1e-57
gi|66932918 MER receptor tyrosine kinase precursor [Homo sapiens]     222   4e-57
gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens]     220   1e-56
gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens]         220   1e-56
gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens]         220   1e-56
gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]         220   1e-56
gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]           220   1e-56
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs...   219   2e-56
gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens]     219   3e-56
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu...   218   6e-56
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu...   218   6e-56
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu...   218   6e-56
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu...   218   6e-56
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu...   218   6e-56
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu...   218   6e-56
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu...   218   6e-56
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu...   218   6e-56
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu...   218   7e-56
gi|32967311 ephrin receptor EphA2 [Homo sapiens]                      217   1e-55

>gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]
          Length = 2347

 Score = 4787 bits (12416), Expect = 0.0
 Identities = 2347/2347 (100%), Positives = 2347/2347 (100%)

Query: 1    MKNIYCLIPKLVNFATLGCLWISVVQCTVLNSCLKSCVTNLGQQLDLGTPHNLSEPCIQG 60
            MKNIYCLIPKLVNFATLGCLWISVVQCTVLNSCLKSCVTNLGQQLDLGTPHNLSEPCIQG
Sbjct: 1    MKNIYCLIPKLVNFATLGCLWISVVQCTVLNSCLKSCVTNLGQQLDLGTPHNLSEPCIQG 60

Query: 61   CHFWNSVDQKNCALKCRESCEVGCSSAEGAYEEEVLENADLPTAPFASSIGSHNMTLRWK 120
            CHFWNSVDQKNCALKCRESCEVGCSSAEGAYEEEVLENADLPTAPFASSIGSHNMTLRWK
Sbjct: 61   CHFWNSVDQKNCALKCRESCEVGCSSAEGAYEEEVLENADLPTAPFASSIGSHNMTLRWK 120

Query: 121  SANFSGVKYIIQWKYAQLLGSWTYTKTVSRPSYVVKPLHPFTEYIFRVVWIFTAQLQLYS 180
            SANFSGVKYIIQWKYAQLLGSWTYTKTVSRPSYVVKPLHPFTEYIFRVVWIFTAQLQLYS
Sbjct: 121  SANFSGVKYIIQWKYAQLLGSWTYTKTVSRPSYVVKPLHPFTEYIFRVVWIFTAQLQLYS 180

Query: 181  PPSPSYRTHPHGVPETAPLIRNIESSSPDTVEVSWDPPQFPGGPILGYNLRLISKNQKLD 240
            PPSPSYRTHPHGVPETAPLIRNIESSSPDTVEVSWDPPQFPGGPILGYNLRLISKNQKLD
Sbjct: 181  PPSPSYRTHPHGVPETAPLIRNIESSSPDTVEVSWDPPQFPGGPILGYNLRLISKNQKLD 240

Query: 241  AGTQRTSFQFYSTLPNTIYRFSIAAVNEVGEGPEAESSITTSSSAVQQEEQWLFLSRKTS 300
            AGTQRTSFQFYSTLPNTIYRFSIAAVNEVGEGPEAESSITTSSSAVQQEEQWLFLSRKTS
Sbjct: 241  AGTQRTSFQFYSTLPNTIYRFSIAAVNEVGEGPEAESSITTSSSAVQQEEQWLFLSRKTS 300

Query: 301  LRKRSLKHLVDEAHCLRLDAIYHNITGISVDVHQQIVYFSEGTLIWAKKAANMSDVSDLR 360
            LRKRSLKHLVDEAHCLRLDAIYHNITGISVDVHQQIVYFSEGTLIWAKKAANMSDVSDLR
Sbjct: 301  LRKRSLKHLVDEAHCLRLDAIYHNITGISVDVHQQIVYFSEGTLIWAKKAANMSDVSDLR 360

Query: 361  IFYRGSGLISSISIDWLYQRMYFIMDELVCVCDLENCSNIEEITPPSISAPQKIVADSYN 420
            IFYRGSGLISSISIDWLYQRMYFIMDELVCVCDLENCSNIEEITPPSISAPQKIVADSYN
Sbjct: 361  IFYRGSGLISSISIDWLYQRMYFIMDELVCVCDLENCSNIEEITPPSISAPQKIVADSYN 420

Query: 421  GYVFYLLRDGIYRADLPVPSGRCAEAVRIVESCTLKDFAIKPQAKRIIYFNDTAQVFMST 480
            GYVFYLLRDGIYRADLPVPSGRCAEAVRIVESCTLKDFAIKPQAKRIIYFNDTAQVFMST
Sbjct: 421  GYVFYLLRDGIYRADLPVPSGRCAEAVRIVESCTLKDFAIKPQAKRIIYFNDTAQVFMST 480

Query: 481  FLDGSASHLILPRIPFADVKSFACENNDFLVTDGKVIFQQDALSFNEFIVGCDLSHIEEF 540
            FLDGSASHLILPRIPFADVKSFACENNDFLVTDGKVIFQQDALSFNEFIVGCDLSHIEEF
Sbjct: 481  FLDGSASHLILPRIPFADVKSFACENNDFLVTDGKVIFQQDALSFNEFIVGCDLSHIEEF 540

Query: 541  GFGNLVIFGSSSQLHPLPGRPQELSVLFGSHQALVQWKPPALAIGANVILISDIIELFEL 600
            GFGNLVIFGSSSQLHPLPGRPQELSVLFGSHQALVQWKPPALAIGANVILISDIIELFEL
Sbjct: 541  GFGNLVIFGSSSQLHPLPGRPQELSVLFGSHQALVQWKPPALAIGANVILISDIIELFEL 600

Query: 601  GPSAWQNWTYEVKVSTQDPPEVTHIFLNISGTMLNVPELQSAMKYKVSVRASSPKRPGPW 660
            GPSAWQNWTYEVKVSTQDPPEVTHIFLNISGTMLNVPELQSAMKYKVSVRASSPKRPGPW
Sbjct: 601  GPSAWQNWTYEVKVSTQDPPEVTHIFLNISGTMLNVPELQSAMKYKVSVRASSPKRPGPW 660

Query: 661  SEPSVGTTLVPASEPPFIMAVKEDGLWSKPLNSFGPGEFLSSDIGNVSDMDWYNNSLYYS 720
            SEPSVGTTLVPASEPPFIMAVKEDGLWSKPLNSFGPGEFLSSDIGNVSDMDWYNNSLYYS
Sbjct: 661  SEPSVGTTLVPASEPPFIMAVKEDGLWSKPLNSFGPGEFLSSDIGNVSDMDWYNNSLYYS 720

Query: 721  DTKGDVFVWLLNGTDISENYHLPSIAGAGALAFEWLGHFLYWAGKTYVIQRQSVLTGHTD 780
            DTKGDVFVWLLNGTDISENYHLPSIAGAGALAFEWLGHFLYWAGKTYVIQRQSVLTGHTD
Sbjct: 721  DTKGDVFVWLLNGTDISENYHLPSIAGAGALAFEWLGHFLYWAGKTYVIQRQSVLTGHTD 780

Query: 781  IVTHVKLLVNDMVVDSVGGYLYWTTLYSVESTRLNGESSLVLQTQPWFSGKKVIALTLDL 840
            IVTHVKLLVNDMVVDSVGGYLYWTTLYSVESTRLNGESSLVLQTQPWFSGKKVIALTLDL
Sbjct: 781  IVTHVKLLVNDMVVDSVGGYLYWTTLYSVESTRLNGESSLVLQTQPWFSGKKVIALTLDL 840

Query: 841  SDGLLYWLVQDSQCIHLYTAVLRGQSTGDTTITEFAAWSTSEISQNALMYYSGRLFWING 900
            SDGLLYWLVQDSQCIHLYTAVLRGQSTGDTTITEFAAWSTSEISQNALMYYSGRLFWING
Sbjct: 841  SDGLLYWLVQDSQCIHLYTAVLRGQSTGDTTITEFAAWSTSEISQNALMYYSGRLFWING 900

Query: 901  FRIITTQEIGQKTSVSVLEPARFNQFTIIQTSLKPLPGNFSFTPKVIPDSVQESSFRIEG 960
            FRIITTQEIGQKTSVSVLEPARFNQFTIIQTSLKPLPGNFSFTPKVIPDSVQESSFRIEG
Sbjct: 901  FRIITTQEIGQKTSVSVLEPARFNQFTIIQTSLKPLPGNFSFTPKVIPDSVQESSFRIEG 960

Query: 961  NASSFQILWNGPPAVDWGVVFYSVEFSAHSKFLASEQHSLPVFTVEGLEPYALFNLSVTP 1020
            NASSFQILWNGPPAVDWGVVFYSVEFSAHSKFLASEQHSLPVFTVEGLEPYALFNLSVTP
Sbjct: 961  NASSFQILWNGPPAVDWGVVFYSVEFSAHSKFLASEQHSLPVFTVEGLEPYALFNLSVTP 1020

Query: 1021 YTYWGKGPKTSLSLRAPETVPSAPENPRIFILPSGKCCNKNEVVVEFRWNKPKHENGVLT 1080
            YTYWGKGPKTSLSLRAPETVPSAPENPRIFILPSGKCCNKNEVVVEFRWNKPKHENGVLT
Sbjct: 1021 YTYWGKGPKTSLSLRAPETVPSAPENPRIFILPSGKCCNKNEVVVEFRWNKPKHENGVLT 1080

Query: 1081 KFEIFYNISNQSITNKTCEDWIAVNVTPSVMSFQLEGMSPRCFIAFQVRAFTSKGPGPYA 1140
            KFEIFYNISNQSITNKTCEDWIAVNVTPSVMSFQLEGMSPRCFIAFQVRAFTSKGPGPYA
Sbjct: 1081 KFEIFYNISNQSITNKTCEDWIAVNVTPSVMSFQLEGMSPRCFIAFQVRAFTSKGPGPYA 1140

Query: 1141 DVVKSTTSEINPFPHLITLLGNKIVFLDMDQNQVVWTFSAERVISAVCYTADNEMGYYAE 1200
            DVVKSTTSEINPFPHLITLLGNKIVFLDMDQNQVVWTFSAERVISAVCYTADNEMGYYAE
Sbjct: 1141 DVVKSTTSEINPFPHLITLLGNKIVFLDMDQNQVVWTFSAERVISAVCYTADNEMGYYAE 1200

Query: 1201 GDSLFLLHLHNRSSSELFQDSLVFDITVITIDWISRHLYFALKESQNGMQVFDVDLEHKV 1260
            GDSLFLLHLHNRSSSELFQDSLVFDITVITIDWISRHLYFALKESQNGMQVFDVDLEHKV
Sbjct: 1201 GDSLFLLHLHNRSSSELFQDSLVFDITVITIDWISRHLYFALKESQNGMQVFDVDLEHKV 1260

Query: 1261 KYPREVKIHNRNSTIISFSVYPLLSRLYWTEVSNFGYQMFYYSIISHTLHRILQPTATNQ 1320
            KYPREVKIHNRNSTIISFSVYPLLSRLYWTEVSNFGYQMFYYSIISHTLHRILQPTATNQ
Sbjct: 1261 KYPREVKIHNRNSTIISFSVYPLLSRLYWTEVSNFGYQMFYYSIISHTLHRILQPTATNQ 1320

Query: 1321 QNKRNQCSCNVTEFELSGAMAIDTSNLEKPLIYFAKAQEIWAMDLEGCQCWRVITVPAML 1380
            QNKRNQCSCNVTEFELSGAMAIDTSNLEKPLIYFAKAQEIWAMDLEGCQCWRVITVPAML
Sbjct: 1321 QNKRNQCSCNVTEFELSGAMAIDTSNLEKPLIYFAKAQEIWAMDLEGCQCWRVITVPAML 1380

Query: 1381 AGKTLVSLTVDGDLIYWIITAKDSTQIYQAKKGNGAIVSQVKALRSRHILAYSSVMQPFP 1440
            AGKTLVSLTVDGDLIYWIITAKDSTQIYQAKKGNGAIVSQVKALRSRHILAYSSVMQPFP
Sbjct: 1381 AGKTLVSLTVDGDLIYWIITAKDSTQIYQAKKGNGAIVSQVKALRSRHILAYSSVMQPFP 1440

Query: 1441 DKAFLSLASDTVEPTILNATNTSLTIRLPLAKTNLTWYGITSPTPTYLVYYAEVNDRKNS 1500
            DKAFLSLASDTVEPTILNATNTSLTIRLPLAKTNLTWYGITSPTPTYLVYYAEVNDRKNS
Sbjct: 1441 DKAFLSLASDTVEPTILNATNTSLTIRLPLAKTNLTWYGITSPTPTYLVYYAEVNDRKNS 1500

Query: 1501 SDLKYRILEFQDSIALIEDLQPFSTYMIQIAVKNYYSDPLEHLPPGKEIWGKTKNGVPEA 1560
            SDLKYRILEFQDSIALIEDLQPFSTYMIQIAVKNYYSDPLEHLPPGKEIWGKTKNGVPEA
Sbjct: 1501 SDLKYRILEFQDSIALIEDLQPFSTYMIQIAVKNYYSDPLEHLPPGKEIWGKTKNGVPEA 1560

Query: 1561 VQLINTTVRSDTSLIISWRESHKPNGPKESVRYQLAISHLALIPETPLRQSEFPNGRLTL 1620
            VQLINTTVRSDTSLIISWRESHKPNGPKESVRYQLAISHLALIPETPLRQSEFPNGRLTL
Sbjct: 1561 VQLINTTVRSDTSLIISWRESHKPNGPKESVRYQLAISHLALIPETPLRQSEFPNGRLTL 1620

Query: 1621 LVTRLSGGNIYVLKVLACHSEEMWCTESHPVTVEMFNTPEKPYSLVPENTSLQFNWKAPL 1680
            LVTRLSGGNIYVLKVLACHSEEMWCTESHPVTVEMFNTPEKPYSLVPENTSLQFNWKAPL
Sbjct: 1621 LVTRLSGGNIYVLKVLACHSEEMWCTESHPVTVEMFNTPEKPYSLVPENTSLQFNWKAPL 1680

Query: 1681 NVNLIRFWVELQKWKYNEFYHVKTSCSQGPAYVCNITNLQPYTSYNVRVVVVYKTGENST 1740
            NVNLIRFWVELQKWKYNEFYHVKTSCSQGPAYVCNITNLQPYTSYNVRVVVVYKTGENST
Sbjct: 1681 NVNLIRFWVELQKWKYNEFYHVKTSCSQGPAYVCNITNLQPYTSYNVRVVVVYKTGENST 1740

Query: 1741 SLPESFKTKAGVPNKPGIPKLLEGSKNSIQWEKAEDNGCRITYYILEIRKSTSNNLQNQN 1800
            SLPESFKTKAGVPNKPGIPKLLEGSKNSIQWEKAEDNGCRITYYILEIRKSTSNNLQNQN
Sbjct: 1741 SLPESFKTKAGVPNKPGIPKLLEGSKNSIQWEKAEDNGCRITYYILEIRKSTSNNLQNQN 1800

Query: 1801 LRWKMTFNGSCSSVCTWKSKNLKGIFQFRVVAANNLGFGEYSGISENIILVGDDFWIPET 1860
            LRWKMTFNGSCSSVCTWKSKNLKGIFQFRVVAANNLGFGEYSGISENIILVGDDFWIPET
Sbjct: 1801 LRWKMTFNGSCSSVCTWKSKNLKGIFQFRVVAANNLGFGEYSGISENIILVGDDFWIPET 1860

Query: 1861 SFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLAN 1920
            SFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLAN
Sbjct: 1861 SFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLAN 1920

Query: 1921 ACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVK 1980
            ACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVK
Sbjct: 1921 ACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVK 1980

Query: 1981 TLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRK 2040
            TLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRK
Sbjct: 1981 TLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRK 2040

Query: 2041 ARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKI 2100
            ARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKI
Sbjct: 2041 ARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKI 2100

Query: 2101 GDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQ 2160
            GDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQ
Sbjct: 2101 GDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQ 2160

Query: 2161 PYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRN 2220
            PYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRN
Sbjct: 2161 PYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRN 2220

Query: 2221 FFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATE 2280
            FFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATE
Sbjct: 2221 FFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATE 2280

Query: 2281 CGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHS 2340
            CGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHS
Sbjct: 2281 CGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHS 2340

Query: 2341 GYGDGSD 2347
            GYGDGSD
Sbjct: 2341 GYGDGSD 2347


>gi|29029632 anaplastic lymphoma kinase [Homo sapiens]
          Length = 1620

 Score =  301 bits (772), Expect = 4e-81
 Identities = 180/462 (38%), Positives = 277/462 (59%), Gaps = 38/462 (8%)

Query: 1858 PETSFILTIIVGIF---LVVTIPLTF----VWHRRLKNQKSAKEGVTVLINEDKELAELR 1910
            PE    L++I+ +    LV  + L F    + +RR   +  A +    L + + +L++LR
Sbjct: 1027 PEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQ--MELQSPEYKLSKLR 1084

Query: 1911 GLAAGVGL-ANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILG 1969
                      N C+A  T      I +L   PR+ +TL   LG GAFGEVYEG  V  + 
Sbjct: 1085 TSTIMTDYNPNYCFAGKT----SSISDLKEVPRKNITLIRGLGHGAFGEVYEGQ-VSGMP 1139

Query: 1970 VGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELM 2029
                 ++VAVKTL +  ++Q++++FL EA ++SKFNH NI++ +GV L + P++I+LELM
Sbjct: 1140 NDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELM 1199

Query: 2030 EGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSV 2089
             GGDL ++LR+ R        L ++DL+ +  DI+ GC YLE  HFIHRD+AARNCL++ 
Sbjct: 1200 AGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTC 1259

Query: 2090 KDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGI 2149
                  R+ KIGDFG+ARDIY+  YYRK G  +LPV+WM PE+ M+GIFT+++D WSFG+
Sbjct: 1260 PG--PGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGV 1317

Query: 2150 LIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFH 2209
            L+WEI +LG+ PYP+ SN +VL +V +GGR++PP+NCP  ++ +MTQCW  +P+ RP F 
Sbjct: 1318 LLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFA 1377

Query: 2210 RIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNR 2269
             I ++++          Y ++D      VIN +   E G ++    ++ +PV     K+ 
Sbjct: 1378 IILERIE----------YCTQD----PDVINTALPIEYGPLV--EEEEKVPV---RPKDP 1418

Query: 2270 EGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHA 2311
            EG+  ++++ +  + EE+S        + S G  K  K+P A
Sbjct: 1419 EGVPPLLVSQQAKREEERSPAAPPPLPTTSSG--KAAKKPTA 1458


>gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precursor
            [Homo sapiens]
          Length = 864

 Score =  285 bits (730), Expect = 3e-76
 Identities = 141/307 (45%), Positives = 206/307 (67%), Gaps = 10/307 (3%)

Query: 1945 LTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKF 2004
            +TL   LG GAFGEVYEG  + + G  S  ++VA+KTL +  + Q++++FL EA ++SKF
Sbjct: 510  VTLLRALGHGAFGEVYEGLVIGLPG-DSSPLQVAIKTLPELCSPQDELDFLMEALIISKF 568

Query: 2005 NHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDIS 2064
             H NI++ +G+ L   P+ I+LELM GGD+ ++LR +R        L + DL+ L  DI+
Sbjct: 569  RHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIA 628

Query: 2065 KGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLP 2124
            +GC YLE  HFIHRD+AARNCL+S    +  R+ KIGDFG+ARDIY+  YYR+    LLP
Sbjct: 629  QGCHYLEENHFIHRDIAARNCLLSCAGPS--RVAKIGDFGMARDIYRASYYRRGDRALLP 686

Query: 2125 VRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPR 2184
            V+WM PE+ ++GIFT+++D WSFG+L+WEI +LG+ PYP  +N +VL++V  GGR++PPR
Sbjct: 687  VKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPR 746

Query: 2185 NCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQ-------LFRNFFLNSIYKSRDEANNSG 2237
             CP  ++ +MTQCW  EP+ RP+F  I ++LQ       +  +     +  + +E   SG
Sbjct: 747  GCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSG 806

Query: 2238 VINESFE 2244
            + N S E
Sbjct: 807  LGNRSLE 813


>gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precursor
            [Homo sapiens]
          Length = 803

 Score =  285 bits (730), Expect = 3e-76
 Identities = 141/307 (45%), Positives = 206/307 (67%), Gaps = 10/307 (3%)

Query: 1945 LTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKF 2004
            +TL   LG GAFGEVYEG  + + G  S  ++VA+KTL +  + Q++++FL EA ++SKF
Sbjct: 449  VTLLRALGHGAFGEVYEGLVIGLPG-DSSPLQVAIKTLPELCSPQDELDFLMEALIISKF 507

Query: 2005 NHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDIS 2064
             H NI++ +G+ L   P+ I+LELM GGD+ ++LR +R        L + DL+ L  DI+
Sbjct: 508  RHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIA 567

Query: 2065 KGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLP 2124
            +GC YLE  HFIHRD+AARNCL+S    +  R+ KIGDFG+ARDIY+  YYR+    LLP
Sbjct: 568  QGCHYLEENHFIHRDIAARNCLLSCAGPS--RVAKIGDFGMARDIYRASYYRRGDRALLP 625

Query: 2125 VRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPR 2184
            V+WM PE+ ++GIFT+++D WSFG+L+WEI +LG+ PYP  +N +VL++V  GGR++PPR
Sbjct: 626  VKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPR 685

Query: 2185 NCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQ-------LFRNFFLNSIYKSRDEANNSG 2237
             CP  ++ +MTQCW  EP+ RP+F  I ++LQ       +  +     +  + +E   SG
Sbjct: 686  GCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSG 745

Query: 2238 VINESFE 2244
            + N S E
Sbjct: 746  LGNRSLE 752


>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
            sapiens]
          Length = 1367

 Score =  270 bits (689), Expect = 2e-71
 Identities = 157/397 (39%), Positives = 222/397 (55%), Gaps = 47/397 (11%)

Query: 1834 NNLGFGEYSGISENIILVGDDFWIPETSFILTIIVG----IFLVVTIPLT---------- 1879
            N L  G Y+   +   L G+  W     F +    G    I L++ +P+           
Sbjct: 894  NRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKTGYENFIHLIIALPVAVLLIVGGLVI 953

Query: 1880 --FVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENL 1937
              +V+HR+  N +     +   +N +   A                A   +P + E+   
Sbjct: 954  MLYVFHRKRNNSRLGNGVLYASVNPEYFSA----------------ADVYVPDEWEVA-- 995

Query: 1938 PAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKE 1997
                REK+T+   LG G+FG VYEG A  ++     E +VA+KT+ + ++ +E+IEFL E
Sbjct: 996  ----REKITMSRELGQGSFGMVYEGVAKGVVK-DEPETRVAIKTVNEAASMRERIEFLNE 1050

Query: 1998 AHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLL---TLV 2054
            A +M +FN  ++++ LGV    +P  +I+ELM  GDL +YLR  R      P+L   +L 
Sbjct: 1051 ASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLS 1110

Query: 2055 DLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDY 2114
             ++ +  +I+ G  YL    F+HRDLAARNC+V+ +D+T    VKIGDFG+ RDIY+ DY
Sbjct: 1111 KMIQMAGEIADGMAYLNANKFVHRDLAARNCMVA-EDFT----VKIGDFGMTRDIYETDY 1165

Query: 2115 YRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYV 2174
            YRK G+GLLPVRWM+PESL DG+FTT SDVWSFG+++WEI TL  QPY   SN  VL +V
Sbjct: 1166 YRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV 1225

Query: 2175 QTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRI 2211
              GG L+ P NCPD L+ LM  CW   P  RP+F  I
Sbjct: 1226 MEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI 1262



 Score = 32.7 bits (73), Expect = 4.3
 Identities = 29/129 (22%), Positives = 50/129 (38%), Gaps = 5/129 (3%)

Query: 151 PSYVVKPLHPFTEYIFRVVWIFTAQLQ---LYSPPSPSYRTHPHGVPETAPLIRNIESSS 207
           P  ++  L P+T+Y   V  +    ++   +    S       +    + PL     S+S
Sbjct: 564 PGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNS 623

Query: 208 PDTVEVSWDPPQFPGGPILGYNLRLISKNQKLDAGTQRTSFQFYSTLPNTIYRFSIAAVN 267
              + V W+PP  P G +  Y +R   + Q  D    R ++     +P   Y      + 
Sbjct: 624 SSQLIVKWNPPSLPNGNLSYYIVRW--QRQPQDGYLYRHNYCSKDKIPIRKYADGTIDIE 681

Query: 268 EVGEGPEAE 276
           EV E P+ E
Sbjct: 682 EVTENPKTE 690



 Score = 32.3 bits (72), Expect = 5.6
 Identities = 38/203 (18%), Positives = 77/203 (37%), Gaps = 24/203 (11%)

Query: 1391 DGDLIYWIITAKDSTQIYQAKKGNGAIVSQVKALRS--RHILAYSSVMQPFPDKAFLSLA 1448
            DG +    +T    T++   +KG      + +A +   +    Y  V + F   +     
Sbjct: 675  DGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPR 734

Query: 1449 SDTVEPTILNATNTSLTIRLPLAKTNLTWYGITSPTPT---YLVYYAEVNDRKNSSDLKY 1505
             +     ++   NT+++ R     T    Y IT P      Y  + + V++++ +     
Sbjct: 735  PERKRRDVMQVANTTMSSR-SRNTTAADTYNITDPEELETEYPFFESRVDNKERT----- 788

Query: 1506 RILEFQDSIALIEDLQPFSTYMIQIAVKNYYSDPLEHLPPGKEIWGKTK--NGVPEAVQL 1563
                      +I +L+PF+ Y I I   N+ ++ L        ++ +T    G  +    
Sbjct: 789  ----------VISNLRPFTLYRIDIHSCNHEAEKLG-CSASNFVFARTMPAEGADDIPGP 837

Query: 1564 INTTVRSDTSLIISWRESHKPNG 1586
            +    R + S+ + W E   PNG
Sbjct: 838  VTWEPRPENSIFLKWPEPENPNG 860


>gi|119395738 insulin receptor isoform Short precursor [Homo sapiens]
          Length = 1370

 Score =  267 bits (682), Expect = 1e-70
 Identities = 138/278 (49%), Positives = 184/278 (66%), Gaps = 9/278 (3%)

Query: 1942 REKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLM 2001
            REK+TL   LG G+FG VYEG A DI+  G  E +VAVKT+ + ++ +E+IEFL EA +M
Sbjct: 1008 REKITLLRELGQGSFGMVYEGNARDIIK-GEAETRVAVKTVNESASLRERIEFLNEASVM 1066

Query: 2002 SKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLL---TLVDLVD 2058
              F   ++++ LGV    +P  +++ELM  GDL +YLR  R      P     TL +++ 
Sbjct: 1067 KGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQ 1126

Query: 2059 LCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKR 2118
            +  +I+ G  YL    F+HRDLAARNC+V+  D+T    VKIGDFG+ RDIY+ DYYRK 
Sbjct: 1127 MAAEIADGMAYLNAKKFVHRDLAARNCMVA-HDFT----VKIGDFGMTRDIYETDYYRKG 1181

Query: 2119 GEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGG 2178
            G+GLLPVRWMAPESL DG+FTT SD+WSFG+++WEI +L  QPY   SN  VL +V  GG
Sbjct: 1182 GKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGG 1241

Query: 2179 RLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQ 2216
             L+ P NCP+ + +LM  CW   P  RPTF  I + L+
Sbjct: 1242 YLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLK 1279



 Score = 34.3 bits (77), Expect = 1.5
 Identities = 21/85 (24%), Positives = 37/85 (43%), Gaps = 2/85 (2%)

Query: 146 KTVSRPSYVVKPLHPFTEYIFRVVWI--FTAQLQLYSPPSPSYRTHPHGVPETAPLIRNI 203
           K+ + P ++++ L P+T+Y   V  +  F+ + + Y   S            + PL    
Sbjct: 571 KSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPIS 630

Query: 204 ESSSPDTVEVSWDPPQFPGGPILGY 228
            S+S   + + W PP  P G I  Y
Sbjct: 631 VSNSSSQIILKWKPPSDPNGNITHY 655


>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
          Length = 1382

 Score =  267 bits (682), Expect = 1e-70
 Identities = 138/278 (49%), Positives = 184/278 (66%), Gaps = 9/278 (3%)

Query: 1942 REKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLM 2001
            REK+TL   LG G+FG VYEG A DI+  G  E +VAVKT+ + ++ +E+IEFL EA +M
Sbjct: 1020 REKITLLRELGQGSFGMVYEGNARDIIK-GEAETRVAVKTVNESASLRERIEFLNEASVM 1078

Query: 2002 SKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLL---TLVDLVD 2058
              F   ++++ LGV    +P  +++ELM  GDL +YLR  R      P     TL +++ 
Sbjct: 1079 KGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQ 1138

Query: 2059 LCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKR 2118
            +  +I+ G  YL    F+HRDLAARNC+V+  D+T    VKIGDFG+ RDIY+ DYYRK 
Sbjct: 1139 MAAEIADGMAYLNAKKFVHRDLAARNCMVA-HDFT----VKIGDFGMTRDIYETDYYRKG 1193

Query: 2119 GEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGG 2178
            G+GLLPVRWMAPESL DG+FTT SD+WSFG+++WEI +L  QPY   SN  VL +V  GG
Sbjct: 1194 GKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGG 1253

Query: 2179 RLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQ 2216
             L+ P NCP+ + +LM  CW   P  RPTF  I + L+
Sbjct: 1254 YLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLK 1291



 Score = 34.3 bits (77), Expect = 1.5
 Identities = 21/85 (24%), Positives = 37/85 (43%), Gaps = 2/85 (2%)

Query: 146 KTVSRPSYVVKPLHPFTEYIFRVVWI--FTAQLQLYSPPSPSYRTHPHGVPETAPLIRNI 203
           K+ + P ++++ L P+T+Y   V  +  F+ + + Y   S            + PL    
Sbjct: 571 KSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPIS 630

Query: 204 ESSSPDTVEVSWDPPQFPGGPILGY 228
            S+S   + + W PP  P G I  Y
Sbjct: 631 VSNSSSQIILKWKPPSDPNGNITHY 655


>gi|31657140 insulin receptor-related receptor precursor [Homo
            sapiens]
          Length = 1297

 Score =  258 bits (658), Expect = 6e-68
 Identities = 143/294 (48%), Positives = 188/294 (63%), Gaps = 11/294 (3%)

Query: 1941 PREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHL 2000
            PRE++++   LG G+FG VYEG A   L  G     VA+KT+ + ++ +E IEFLKEA +
Sbjct: 975  PREQISIIRELGQGSFGMVYEGLARG-LEAGEESTPVALKTVNELASPRECIEFLKEASV 1033

Query: 2001 MSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLL---TLVDLV 2057
            M  F   ++++ LGV    +P  +I+ELM  GDL ++LR  R      P L    L +++
Sbjct: 1034 MKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQPALGEMI 1093

Query: 2058 DLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRK 2117
             +  +I+ G  YL    F+HRDLAARNC+VS +D+T    VKIGDFG+ RD+Y+ DYYRK
Sbjct: 1094 QMAGEIADGMAYLAANKFVHRDLAARNCMVS-QDFT----VKIGDFGMTRDVYETDYYRK 1148

Query: 2118 RGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTG 2177
             G+GLLPVRWMAPESL DGIFTT SDVWSFG+++WEI+TL  QPY   SN  VL +V  G
Sbjct: 1149 GGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDG 1208

Query: 2178 GRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQ--LFRNFFLNSIYKS 2229
            G LE    CP  L  LM++CW   P  RP+F  I D +Q  L  +F L S Y S
Sbjct: 1209 GVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQEELRPSFRLLSFYYS 1262


>gi|208879423 leukocyte receptor tyrosine kinase isoform 3 precursor
            [Homo sapiens]
          Length = 734

 Score =  256 bits (654), Expect = 2e-67
 Identities = 123/274 (44%), Positives = 184/274 (67%), Gaps = 9/274 (3%)

Query: 1978 AVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTY 2037
            + +TL +  + Q++++FL EA ++SKF H NI++ +G+ L   P+ I+LELM GGD+ ++
Sbjct: 412  SAQTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSF 471

Query: 2038 LRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRI 2097
            LR +R        L + DL+ L  DI++GC YLE  HFIHRD+AARNCL+S    +  R+
Sbjct: 472  LRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPS--RV 529

Query: 2098 VKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTL 2157
             KIGDFG+ARDIY+  YYR+    LLPV+WM PE+ ++GIFT+++D WSFG+L+WEI +L
Sbjct: 530  AKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSL 589

Query: 2158 GHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQ- 2216
            G+ PYP  +N +VL++V  GGR++PPR CP  ++ +MTQCW  EP+ RP+F  I ++LQ 
Sbjct: 590  GYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQY 649

Query: 2217 ------LFRNFFLNSIYKSRDEANNSGVINESFE 2244
                  +  +     +  + +E   SG+ N S E
Sbjct: 650  CTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLE 683


>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
          Length = 1072

 Score =  234 bits (596), Expect = 1e-60
 Identities = 127/297 (42%), Positives = 176/297 (59%), Gaps = 29/297 (9%)

Query: 1940 FPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAH 1999
            FPR+ L L   LG G FG+V + TA  + G  +G   VAVK LK+ ++  E  + L E +
Sbjct: 719  FPRKNLVLGKTLGEGEFGKVVKATAFHLKG-RAGYTTVAVKMLKENASPSELRDLLSEFN 777

Query: 2000 LMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGP---------- 2049
            ++ + NHP+++K  G C  + P  +I+E  + G L  +LR++R     GP          
Sbjct: 778  VLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKV---GPGYLGSGGSRN 834

Query: 2050 ----------LLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVK 2099
                       LT+ DL+     IS+G  YL  M  +HRDLAARN LV+       R +K
Sbjct: 835  SSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVA-----EGRKMK 889

Query: 2100 IGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGH 2159
            I DFGL+RD+Y+ D Y KR +G +PV+WMA ESL D I+TTQSDVWSFG+L+WEI+TLG 
Sbjct: 890  ISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGG 949

Query: 2160 QPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQ 2216
             PYP      + N ++TG R+E P NC ++++ LM QCW QEPD+RP F  I   L+
Sbjct: 950  NPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLE 1006


>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
          Length = 1114

 Score =  234 bits (596), Expect = 1e-60
 Identities = 127/297 (42%), Positives = 176/297 (59%), Gaps = 29/297 (9%)

Query: 1940 FPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAH 1999
            FPR+ L L   LG G FG+V + TA  + G  +G   VAVK LK+ ++  E  + L E +
Sbjct: 719  FPRKNLVLGKTLGEGEFGKVVKATAFHLKG-RAGYTTVAVKMLKENASPSELRDLLSEFN 777

Query: 2000 LMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGP---------- 2049
            ++ + NHP+++K  G C  + P  +I+E  + G L  +LR++R     GP          
Sbjct: 778  VLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKV---GPGYLGSGGSRN 834

Query: 2050 ----------LLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVK 2099
                       LT+ DL+     IS+G  YL  M  +HRDLAARN LV+       R +K
Sbjct: 835  SSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVA-----EGRKMK 889

Query: 2100 IGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGH 2159
            I DFGL+RD+Y+ D Y KR +G +PV+WMA ESL D I+TTQSDVWSFG+L+WEI+TLG 
Sbjct: 890  ISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGG 949

Query: 2160 QPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQ 2216
             PYP      + N ++TG R+E P NC ++++ LM QCW QEPD+RP F  I   L+
Sbjct: 950  NPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLE 1006


>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
          Length = 822

 Score =  223 bits (569), Expect = 1e-57
 Identities = 116/277 (41%), Positives = 170/277 (61%), Gaps = 19/277 (6%)

Query: 1943 EKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMS 2002
            E + L  LLG G FGEVY+GT  D       +  VAVKT K+    + KI+FL+EA ++ 
Sbjct: 561  EDVILGELLGKGNFGEVYKGTLKD-------KTSVAVKTCKEDLPQELKIKFLQEAKILK 613

Query: 2003 KFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVD 2062
            +++HPNI+K +GVC   +P YII+EL+ GGD LT+LR+ +        L L  LV   +D
Sbjct: 614  QYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDE------LKLKQLVKFSLD 667

Query: 2063 ISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGL 2122
             + G +YLE  + IHRDLAARNCLV   +     ++KI DFG++R       Y   G   
Sbjct: 668  AAAGMLYLESKNCIHRDLAARNCLVGENN-----VLKISDFGMSRQ-EDGGVYSSSGLKQ 721

Query: 2123 LPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEP 2182
            +P++W APE+L  G ++++SDVWSFGIL+WE  +LG  PYP  +N      V+ G R+  
Sbjct: 722  IPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSA 781

Query: 2183 PRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFR 2219
            P++CP+D+  +M +CW  +P+ RP F  +Q +L + +
Sbjct: 782  PQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIK 818


>gi|66932918 MER receptor tyrosine kinase precursor [Homo sapiens]
          Length = 999

 Score =  222 bits (565), Expect = 4e-57
 Identities = 134/334 (40%), Positives = 193/334 (57%), Gaps = 24/334 (7%)

Query: 1925 IHTLPTQEEIENL---PAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKT 1981
            +H+L   EE++N        R  L L  +LG G FG V EG      G     +KVAVKT
Sbjct: 564  LHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTS---LKVAVKT 620

Query: 1982 LKKGSTDQEKIE-FLKEAHLMSKFNHPNILKQLGVCLLNEPQ-----YIILELMEGGDLL 2035
            +K  ++ Q +IE FL EA  M  F+HPN+++ LGVC+    Q      +IL  M+ GDL 
Sbjct: 621  MKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLH 680

Query: 2036 TYLRKARMATFYGPL-LTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTS 2094
            TYL  +R+ T  GP  + L  L+   VDI+ G  YL   +F+HRDLAARNC++   D T 
Sbjct: 681  TYLLYSRLET--GPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLR-DDMT- 736

Query: 2095 PRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEI 2154
               V + DFGL++ IY  DYYR+     +PV+W+A ESL D ++T++SDVW+FG+ +WEI
Sbjct: 737  ---VCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEI 793

Query: 2155 LTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQ 2214
             T G  PYP   N ++ +Y+  G RL+ P +C D+L+ +M  CW  +P  RPTF  ++ Q
Sbjct: 794  ATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQ 853

Query: 2215 LQLFRNFFLNSIYKSRDEANNSGVINESFEGEDG 2248
            L+      L S+   R++A+   V  +  E  +G
Sbjct: 854  LEK----LLESLPDVRNQADVIYVNTQLLESSEG 883


>gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens]
          Length = 885

 Score =  220 bits (561), Expect = 1e-56
 Identities = 167/542 (30%), Positives = 257/542 (47%), Gaps = 59/542 (10%)

Query: 1704 TSCSQGPAYVCNITNLQPYTSYNVRVVVVYKTGENSTSLPESFKTKAGVPNKP--GIPKL 1761
            TS +  P +   + +L P+T Y++RV      G +S +     +T  GVP  P   I   
Sbjct: 284  TSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISAT 343

Query: 1762 LEGSKNSIQWE--KAEDNGCRITYYILEIRKSTSNNLQNQNLRWKMTF----NGSCSSVC 1815
              GS+  + W+  +A   G  + Y +    + T   L +  LR ++T     +GS S++ 
Sbjct: 344  RNGSQAFVHWQEPRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLT 403

Query: 1816 TWKSKNLKGIFQFRVVAANNLGFGEYSGISENIILVGDDFWIPETS-----------FIL 1864
                          V A    G G +S      + V  + W P              ++L
Sbjct: 404  VC------------VAAYTAAGDGPWS------LPVPLEAWRPVKEPSTPAFSWPWWYVL 445

Query: 1865 TIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYA 1924
               V     V I   F+ HRR K  +  +     +  E  EL     +            
Sbjct: 446  LGAVVAAACVLILALFLVHRRKKETRYGEVFEPTV--ERGELVVRYRVRKSYSRRTTEAT 503

Query: 1925 IHTLPTQEEIENL---PAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKT 1981
            +++L   EE++         R K+ L   LG G FG V EG     L      +KVAVKT
Sbjct: 504  LNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQ----LNQDDSILKVAVKT 559

Query: 1982 LKKGSTDQEKIE-FLKEAHLMSKFNHPNILKQLGVCLLNEPQ------YIILELMEGGDL 2034
            +K     + ++E FL EA  M +F+HPN+++ +GVC     +       +IL  M+ GDL
Sbjct: 560  MKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDL 619

Query: 2035 LTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTS 2094
             ++L  +R+      L T + LV    DI+ G  YL    FIHRDLAARNC+++      
Sbjct: 620  HSFLLYSRLGDQPVYLPTQM-LVKFMADIASGMEYLSTKRFIHRDLAARNCMLNEN---- 674

Query: 2095 PRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEI 2154
               V + DFGL++ IY  DYYR+     +PV+W+A ESL D ++T++SDVWSFG+ +WEI
Sbjct: 675  -MSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEI 733

Query: 2155 LTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQ 2214
             T G  PYP   N ++ +Y++ G RL+ P +C D L+ LM++CW   P  RP+F  +++ 
Sbjct: 734  ATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELRED 793

Query: 2215 LQ 2216
            L+
Sbjct: 794  LE 795


>gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens]
          Length = 694

 Score =  220 bits (560), Expect = 1e-56
 Identities = 118/277 (42%), Positives = 167/277 (60%), Gaps = 17/277 (6%)

Query: 1943 EKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMS 2002
            E L L   +G G FGEV+ G       + +    VAVK+ ++      K +FL+EA ++ 
Sbjct: 431  EDLVLGEQIGRGNFGEVFSGR------LRADNTLVAVKSCRETLPPDLKAKFLQEARILK 484

Query: 2003 KFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVD 2062
            +++HPNI++ +GVC   +P YI++EL++GGD LT+LR        G  L +  L+ +  D
Sbjct: 485  QYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTE------GARLRVKTLLQMVGD 538

Query: 2063 ISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGL 2122
             + G  YLE    IHRDLAARNCLV+ K+     ++KI DFG++R+     Y    G   
Sbjct: 539  AAAGMEYLESKCCIHRDLAARNCLVTEKN-----VLKISDFGMSREEADGVYAASGGLRQ 593

Query: 2123 LPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEP 2182
            +PV+W APE+L  G ++++SDVWSFGIL+WE  +LG  PYP  SN     +V+ GGRL  
Sbjct: 594  VPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPC 653

Query: 2183 PRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFR 2219
            P  CPD ++ LM QCWA EP QRP+F  I  +LQ  R
Sbjct: 654  PELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIR 690


>gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens]
          Length = 752

 Score =  220 bits (560), Expect = 1e-56
 Identities = 118/277 (42%), Positives = 167/277 (60%), Gaps = 17/277 (6%)

Query: 1943 EKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMS 2002
            E L L   +G G FGEV+ G       + +    VAVK+ ++      K +FL+EA ++ 
Sbjct: 489  EDLVLGEQIGRGNFGEVFSGR------LRADNTLVAVKSCRETLPPDLKAKFLQEARILK 542

Query: 2003 KFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVD 2062
            +++HPNI++ +GVC   +P YI++EL++GGD LT+LR        G  L +  L+ +  D
Sbjct: 543  QYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTE------GARLRVKTLLQMVGD 596

Query: 2063 ISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGL 2122
             + G  YLE    IHRDLAARNCLV+ K+     ++KI DFG++R+     Y    G   
Sbjct: 597  AAAGMEYLESKCCIHRDLAARNCLVTEKN-----VLKISDFGMSREEADGVYAASGGLRQ 651

Query: 2123 LPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEP 2182
            +PV+W APE+L  G ++++SDVWSFGIL+WE  +LG  PYP  SN     +V+ GGRL  
Sbjct: 652  VPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPC 711

Query: 2183 PRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFR 2219
            P  CPD ++ LM QCWA EP QRP+F  I  +LQ  R
Sbjct: 712  PELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIR 748


>gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]
          Length = 764

 Score =  220 bits (560), Expect = 1e-56
 Identities = 118/277 (42%), Positives = 167/277 (60%), Gaps = 17/277 (6%)

Query: 1943 EKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMS 2002
            E L L   +G G FGEV+ G       + +    VAVK+ ++      K +FL+EA ++ 
Sbjct: 501  EDLVLGEQIGRGNFGEVFSGR------LRADNTLVAVKSCRETLPPDLKAKFLQEARILK 554

Query: 2003 KFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVD 2062
            +++HPNI++ +GVC   +P YI++EL++GGD LT+LR        G  L +  L+ +  D
Sbjct: 555  QYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTE------GARLRVKTLLQMVGD 608

Query: 2063 ISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGL 2122
             + G  YLE    IHRDLAARNCLV+ K+     ++KI DFG++R+     Y    G   
Sbjct: 609  AAAGMEYLESKCCIHRDLAARNCLVTEKN-----VLKISDFGMSREEADGVYAASGGLRQ 663

Query: 2123 LPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEP 2182
            +PV+W APE+L  G ++++SDVWSFGIL+WE  +LG  PYP  SN     +V+ GGRL  
Sbjct: 664  VPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPC 723

Query: 2183 PRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFR 2219
            P  CPD ++ LM QCWA EP QRP+F  I  +LQ  R
Sbjct: 724  PELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIR 760


>gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]
          Length = 822

 Score =  220 bits (560), Expect = 1e-56
 Identities = 118/277 (42%), Positives = 167/277 (60%), Gaps = 17/277 (6%)

Query: 1943 EKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMS 2002
            E L L   +G G FGEV+ G       + +    VAVK+ ++      K +FL+EA ++ 
Sbjct: 559  EDLVLGEQIGRGNFGEVFSGR------LRADNTLVAVKSCRETLPPDLKAKFLQEARILK 612

Query: 2003 KFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVD 2062
            +++HPNI++ +GVC   +P YI++EL++GGD LT+LR        G  L +  L+ +  D
Sbjct: 613  QYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTE------GARLRVKTLLQMVGD 666

Query: 2063 ISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGL 2122
             + G  YLE    IHRDLAARNCLV+ K+     ++KI DFG++R+     Y    G   
Sbjct: 667  AAAGMEYLESKCCIHRDLAARNCLVTEKN-----VLKISDFGMSREEADGVYAASGGLRQ 721

Query: 2123 LPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEP 2182
            +PV+W APE+L  G ++++SDVWSFGIL+WE  +LG  PYP  SN     +V+ GGRL  
Sbjct: 722  VPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPC 781

Query: 2183 PRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFR 2219
            P  CPD ++ LM QCWA EP QRP+F  I  +LQ  R
Sbjct: 782  PELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIR 818


>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
            [Homo sapiens]
          Length = 806

 Score =  219 bits (558), Expect = 2e-56
 Identities = 162/501 (32%), Positives = 237/501 (47%), Gaps = 73/501 (14%)

Query: 1760 KLLEGSKNSIQWEK-AEDNGCRI----TYYILEIRKSTSNNLQNQNLRWKMTFNGSCSSV 1814
            K+   ++  IQW K  E NG ++    T Y+  ++ + +N    +              V
Sbjct: 276  KVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKE------------LEV 323

Query: 1815 CTWKSKNLKGIFQFRVVAANNLGFGEYSG----ISENIILVGDDFWIPETSFILTIIVGI 1870
             +  +   +   ++  +A N++GF  +S     +     LV  D      + IL+  VG 
Sbjct: 324  LSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGF 383

Query: 1871 FLVVTIPLTFVWHRR--------------------LKNQKSAKEGVTVLINEDKELAELR 1910
            FL + +       R                     LK Q S +   ++  N    L  + 
Sbjct: 384  FLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTP--LVRIA 441

Query: 1911 GLAAGVGLANACYAIHTLPTQEEIENLPAFP-----REKLTLRLLLGSGAFGEVYEGTAV 1965
             L++G G         TL    E+E LPA P     R +LTL   LG G FG+V    A+
Sbjct: 442  RLSSGEG--------PTLANVSELE-LPADPKWELSRARLTLGKPLGEGCFGQVVMAEAI 492

Query: 1966 DI-LGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFN-HPNILKQLGVCLLNEPQY 2023
             I     +  + VAVK LK  +TD++  + + E  +M     H NI+  LG C    P Y
Sbjct: 493  GIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLY 552

Query: 2024 IILELMEGGDLLTYLRKAR-------MATFYGP--LLTLVDLVDLCVDISKGCVYLERMH 2074
            +++E    G+L  +LR  R         T   P   LT  DLV     +++G  YL    
Sbjct: 553  VLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQK 612

Query: 2075 FIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLM 2134
             IHRDLAARN LV     T   ++KI DFGLARD++  DYY+K   G LPV+WMAPE+L 
Sbjct: 613  CIHRDLAARNVLV-----TEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALF 667

Query: 2135 DGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLM 2194
            D ++T QSDVWSFG+L+WEI TLG  PYP     ++   ++ G R++ P NC  DL+ +M
Sbjct: 668  DRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIM 727

Query: 2195 TQCWAQEPDQRPTFHRIQDQL 2215
             +CW   P QRPTF ++ + L
Sbjct: 728  RECWHAAPSQRPTFKQLVEDL 748


>gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens]
          Length = 894

 Score =  219 bits (557), Expect = 3e-56
 Identities = 167/546 (30%), Positives = 263/546 (48%), Gaps = 58/546 (10%)

Query: 1704 TSCSQGPAYVCNITNLQPYTSYNVRVVVVYKTGENSTSLPESFKTKAGVPNKP--GIPKL 1761
            TS +  P +   + +L P+T Y++RV      G +S +     +T  GVP  P   I   
Sbjct: 284  TSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISAT 343

Query: 1762 LEGSKNSIQWE--KAEDNGCRITYYILEIRKSTSNNLQNQNLRWKMTF----NGSCSSVC 1815
              GS+  + W+  +A   G  + Y +    + T   L +  LR ++T     +GS S++ 
Sbjct: 344  RNGSQAFVHWQEPRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLT 403

Query: 1816 TWKSKNLKGIFQFRVVAANNLGFGEYS----------GISENIILVGDDFWIPETSF--- 1862
                          V A    G G +S          G ++ +  +  +   P  S+   
Sbjct: 404  VC------------VAAYTAAGDGPWSLPVPLEAWRPGQAQPVHQLVKEPSTPAFSWPWW 451

Query: 1863 --ILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLAN 1920
              +L  +V    V+ + L F+ HRR K  +  +     +  E  EL     +        
Sbjct: 452  YVLLGAVVAAACVLILAL-FLVHRRKKETRYGEVFEPTV--ERGELVVRYRVRKSYSRRT 508

Query: 1921 ACYAIHTLPTQEEIENL---PAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKV 1977
                +++L   EE++         R K+ L   LG G FG V EG     L      +KV
Sbjct: 509  TEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQ----LNQDDSILKV 564

Query: 1978 AVKTLKKGSTDQEKIE-FLKEAHLMSKFNHPNILKQLGVCLLNEPQ------YIILELME 2030
            AVKT+K     + ++E FL EA  M +F+HPN+++ +GVC     +       +IL  M+
Sbjct: 565  AVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMK 624

Query: 2031 GGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVK 2090
             GDL ++L  +R+      L T + LV    DI+ G  YL    FIHRDLAARNC+++  
Sbjct: 625  HGDLHSFLLYSRLGDQPVYLPTQM-LVKFMADIASGMEYLSTKRFIHRDLAARNCMLNEN 683

Query: 2091 DYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGIL 2150
                   V + DFGL++ IY  DYYR+     +PV+W+A ESL D ++T++SDVWSFG+ 
Sbjct: 684  -----MSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVT 738

Query: 2151 IWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHR 2210
            +WEI T G  PYP   N ++ +Y++ G RL+ P +C D L+ LM++CW   P  RP+F  
Sbjct: 739  MWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTE 798

Query: 2211 IQDQLQ 2216
            +++ L+
Sbjct: 799  LREDLE 804



 Score = 32.0 bits (71), Expect = 7.3
 Identities = 38/147 (25%), Positives = 48/147 (32%), Gaps = 34/147 (23%)

Query: 549 GSSSQLHPLP---------GRPQELSVLFGSHQALVQWKPPALAIGANVILISDIIELFE 599
           G SS  H LP         G P+ +S      QA V W+ P   +   ++          
Sbjct: 316 GPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPLQGTLL---------- 365

Query: 600 LGPSAWQNWTYEVKVSTQDPPEVTHIFLNISGTMLNVPELQ---SAMKYKVSVRASSPKR 656
                     Y +    QD PEV    ++I        ELQ   S     V V A +   
Sbjct: 366 ---------GYRLAYQGQDTPEV---LMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAG 413

Query: 657 PGPWSEPSVGTTLVPASEPPFIMAVKE 683
            GPWS P       P    P    VKE
Sbjct: 414 DGPWSLPVPLEAWRPGQAQPVHQLVKE 440


>gi|222144244 fibroblast growth factor receptor 2 isoform 9 precursor
            [Homo sapiens]
          Length = 680

 Score =  218 bits (555), Expect = 6e-56
 Identities = 125/298 (41%), Positives = 166/298 (55%), Gaps = 16/298 (5%)

Query: 1940 FPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGE-IKVAVKTLKKGSTDQEKIEFLKEA 1998
            FPR+KLTL   LG G FG+V    AV I      E + VAVK LK  +T+++  + + E 
Sbjct: 388  FPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEM 447

Query: 1999 HLMSKFN-HPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKAR---MATFYG------ 2048
             +M     H NI+  LG C  + P Y+I+E    G+L  YLR  R   M   Y       
Sbjct: 448  EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPE 507

Query: 2049 PLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARD 2108
              +T  DLV     +++G  YL     IHRDLAARN LV     T   ++KI DFGLARD
Sbjct: 508  EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLV-----TENNVMKIADFGLARD 562

Query: 2109 IYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNL 2168
            I   DYY+K   G LPV+WMAPE+L D ++T QSDVWSFG+L+WEI TLG  PYP     
Sbjct: 563  INNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVE 622

Query: 2169 DVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSI 2226
            ++   ++ G R++ P NC ++L+ +M  CW   P QRPTF ++ + L        N I
Sbjct: 623  ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEI 680


>gi|222144231 fibroblast growth factor receptor 2 isoform 3 precursor
            [Homo sapiens]
          Length = 769

 Score =  218 bits (555), Expect = 6e-56
 Identities = 125/298 (41%), Positives = 166/298 (55%), Gaps = 16/298 (5%)

Query: 1940 FPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGE-IKVAVKTLKKGSTDQEKIEFLKEA 1998
            FPR+KLTL   LG G FG+V    AV I      E + VAVK LK  +T+++  + + E 
Sbjct: 477  FPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEM 536

Query: 1999 HLMSKFN-HPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKAR---MATFYG------ 2048
             +M     H NI+  LG C  + P Y+I+E    G+L  YLR  R   M   Y       
Sbjct: 537  EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPE 596

Query: 2049 PLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARD 2108
              +T  DLV     +++G  YL     IHRDLAARN LV     T   ++KI DFGLARD
Sbjct: 597  EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLV-----TENNVMKIADFGLARD 651

Query: 2109 IYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNL 2168
            I   DYY+K   G LPV+WMAPE+L D ++T QSDVWSFG+L+WEI TLG  PYP     
Sbjct: 652  INNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVE 711

Query: 2169 DVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSI 2226
            ++   ++ G R++ P NC ++L+ +M  CW   P QRPTF ++ + L        N I
Sbjct: 712  ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEI 769


>gi|222144241 fibroblast growth factor receptor 2 isoform 8 precursor
            [Homo sapiens]
          Length = 704

 Score =  218 bits (555), Expect = 6e-56
 Identities = 125/299 (41%), Positives = 166/299 (55%), Gaps = 16/299 (5%)

Query: 1940 FPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGE-IKVAVKTLKKGSTDQEKIEFLKEA 1998
            FPR+KLTL   LG G FG+V    AV I      E + VAVK LK  +T+++  + + E 
Sbjct: 359  FPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEM 418

Query: 1999 HLMSKFN-HPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKAR---MATFYG------ 2048
             +M     H NI+  LG C  + P Y+I+E    G+L  YLR  R   M   Y       
Sbjct: 419  EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPE 478

Query: 2049 PLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARD 2108
              +T  DLV     +++G  YL     IHRDLAARN LV     T   ++KI DFGLARD
Sbjct: 479  EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLV-----TENNVMKIADFGLARD 533

Query: 2109 IYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNL 2168
            I   DYY+K   G LPV+WMAPE+L D ++T QSDVWSFG+L+WEI TLG  PYP     
Sbjct: 534  INNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVE 593

Query: 2169 DVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIY 2227
            ++   ++ G R++ P NC ++L+ +M  CW   P QRPTF ++ + L        N  Y
Sbjct: 594  ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEY 652


>gi|222144239 fibroblast growth factor receptor 2 isoform 7 precursor
            [Homo sapiens]
          Length = 705

 Score =  218 bits (555), Expect = 6e-56
 Identities = 125/299 (41%), Positives = 166/299 (55%), Gaps = 16/299 (5%)

Query: 1940 FPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGE-IKVAVKTLKKGSTDQEKIEFLKEA 1998
            FPR+KLTL   LG G FG+V    AV I      E + VAVK LK  +T+++  + + E 
Sbjct: 360  FPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEM 419

Query: 1999 HLMSKFN-HPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKAR---MATFYG------ 2048
             +M     H NI+  LG C  + P Y+I+E    G+L  YLR  R   M   Y       
Sbjct: 420  EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPE 479

Query: 2049 PLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARD 2108
              +T  DLV     +++G  YL     IHRDLAARN LV     T   ++KI DFGLARD
Sbjct: 480  EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLV-----TENNVMKIADFGLARD 534

Query: 2109 IYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNL 2168
            I   DYY+K   G LPV+WMAPE+L D ++T QSDVWSFG+L+WEI TLG  PYP     
Sbjct: 535  INNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVE 594

Query: 2169 DVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIY 2227
            ++   ++ G R++ P NC ++L+ +M  CW   P QRPTF ++ + L        N  Y
Sbjct: 595  ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEY 653


>gi|222144237 fibroblast growth factor receptor 2 isoform 6 precursor
            [Homo sapiens]
          Length = 706

 Score =  218 bits (555), Expect = 6e-56
 Identities = 125/299 (41%), Positives = 166/299 (55%), Gaps = 16/299 (5%)

Query: 1940 FPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGE-IKVAVKTLKKGSTDQEKIEFLKEA 1998
            FPR+KLTL   LG G FG+V    AV I      E + VAVK LK  +T+++  + + E 
Sbjct: 361  FPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEM 420

Query: 1999 HLMSKFN-HPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKAR---MATFYG------ 2048
             +M     H NI+  LG C  + P Y+I+E    G+L  YLR  R   M   Y       
Sbjct: 421  EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPE 480

Query: 2049 PLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARD 2108
              +T  DLV     +++G  YL     IHRDLAARN LV     T   ++KI DFGLARD
Sbjct: 481  EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLV-----TENNVMKIADFGLARD 535

Query: 2109 IYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNL 2168
            I   DYY+K   G LPV+WMAPE+L D ++T QSDVWSFG+L+WEI TLG  PYP     
Sbjct: 536  INNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVE 595

Query: 2169 DVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIY 2227
            ++   ++ G R++ P NC ++L+ +M  CW   P QRPTF ++ + L        N  Y
Sbjct: 596  ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEY 654


>gi|222144233 fibroblast growth factor receptor 2 isoform 4 precursor
            [Homo sapiens]
          Length = 709

 Score =  218 bits (555), Expect = 6e-56
 Identities = 125/299 (41%), Positives = 166/299 (55%), Gaps = 16/299 (5%)

Query: 1940 FPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGE-IKVAVKTLKKGSTDQEKIEFLKEA 1998
            FPR+KLTL   LG G FG+V    AV I      E + VAVK LK  +T+++  + + E 
Sbjct: 364  FPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEM 423

Query: 1999 HLMSKFN-HPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKAR---MATFYG------ 2048
             +M     H NI+  LG C  + P Y+I+E    G+L  YLR  R   M   Y       
Sbjct: 424  EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPE 483

Query: 2049 PLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARD 2108
              +T  DLV     +++G  YL     IHRDLAARN LV     T   ++KI DFGLARD
Sbjct: 484  EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLV-----TENNVMKIADFGLARD 538

Query: 2109 IYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNL 2168
            I   DYY+K   G LPV+WMAPE+L D ++T QSDVWSFG+L+WEI TLG  PYP     
Sbjct: 539  INNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVE 598

Query: 2169 DVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIY 2227
            ++   ++ G R++ P NC ++L+ +M  CW   P QRPTF ++ + L        N  Y
Sbjct: 599  ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEY 657


>gi|221316639 fibroblast growth factor receptor 2 isoform 1 precursor
            [Homo sapiens]
          Length = 821

 Score =  218 bits (555), Expect = 6e-56
 Identities = 125/299 (41%), Positives = 166/299 (55%), Gaps = 16/299 (5%)

Query: 1940 FPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGE-IKVAVKTLKKGSTDQEKIEFLKEA 1998
            FPR+KLTL   LG G FG+V    AV I      E + VAVK LK  +T+++  + + E 
Sbjct: 476  FPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEM 535

Query: 1999 HLMSKFN-HPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKAR---MATFYG------ 2048
             +M     H NI+  LG C  + P Y+I+E    G+L  YLR  R   M   Y       
Sbjct: 536  EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPE 595

Query: 2049 PLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARD 2108
              +T  DLV     +++G  YL     IHRDLAARN LV     T   ++KI DFGLARD
Sbjct: 596  EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLV-----TENNVMKIADFGLARD 650

Query: 2109 IYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNL 2168
            I   DYY+K   G LPV+WMAPE+L D ++T QSDVWSFG+L+WEI TLG  PYP     
Sbjct: 651  INNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVE 710

Query: 2169 DVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIY 2227
            ++   ++ G R++ P NC ++L+ +M  CW   P QRPTF ++ + L        N  Y
Sbjct: 711  ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEY 769


>gi|221316638 fibroblast growth factor receptor 2 isoform 2 precursor
            [Homo sapiens]
          Length = 822

 Score =  218 bits (555), Expect = 6e-56
 Identities = 125/299 (41%), Positives = 166/299 (55%), Gaps = 16/299 (5%)

Query: 1940 FPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGE-IKVAVKTLKKGSTDQEKIEFLKEA 1998
            FPR+KLTL   LG G FG+V    AV I      E + VAVK LK  +T+++  + + E 
Sbjct: 477  FPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEM 536

Query: 1999 HLMSKFN-HPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKAR---MATFYG------ 2048
             +M     H NI+  LG C  + P Y+I+E    G+L  YLR  R   M   Y       
Sbjct: 537  EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPE 596

Query: 2049 PLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARD 2108
              +T  DLV     +++G  YL     IHRDLAARN LV     T   ++KI DFGLARD
Sbjct: 597  EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLV-----TENNVMKIADFGLARD 651

Query: 2109 IYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNL 2168
            I   DYY+K   G LPV+WMAPE+L D ++T QSDVWSFG+L+WEI TLG  PYP     
Sbjct: 652  INNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVE 711

Query: 2169 DVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIY 2227
            ++   ++ G R++ P NC ++L+ +M  CW   P QRPTF ++ + L        N  Y
Sbjct: 712  ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEY 770


>gi|254028242 fibroblast growth factor receptor 3 isoform 3 precursor
            [Homo sapiens]
          Length = 808

 Score =  218 bits (554), Expect = 7e-56
 Identities = 135/346 (39%), Positives = 185/346 (53%), Gaps = 32/346 (9%)

Query: 1886 LKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFP---- 1941
            LK Q S +   ++  N    L  +  L++G G         TL    E+E LPA P    
Sbjct: 421  LKRQVSLESNASMSSNTP--LVRIARLSSGEG--------PTLANVSELE-LPADPKWEL 469

Query: 1942 -REKLTLRLLLGSGAFGEVYEGTAVDI-LGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAH 1999
             R +LTL   LG G FG+V    A+ I     +  + VAVK LK  +TD++  + + E  
Sbjct: 470  SRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEME 529

Query: 2000 LMSKFN-HPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKAR-------MATFYGP-- 2049
            +M     H NI+  LG C    P Y+++E    G+L  +LR  R         T   P  
Sbjct: 530  MMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEE 589

Query: 2050 LLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDI 2109
             LT  DLV     +++G  YL     IHRDLAARN LV     T   ++KI DFGLARD+
Sbjct: 590  QLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLV-----TEDNVMKIADFGLARDV 644

Query: 2110 YKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLD 2169
            +  DYY+K   G LPV+WMAPE+L D ++T QSDVWSFG+L+WEI TLG  PYP     +
Sbjct: 645  HNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEE 704

Query: 2170 VLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQL 2215
            +   ++ G R++ P NC  DL+ +M +CW   P QRPTF ++ + L
Sbjct: 705  LFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL 750


>gi|32967311 ephrin receptor EphA2 [Homo sapiens]
          Length = 976

 Score =  217 bits (552), Expect = 1e-55
 Identities = 164/509 (32%), Positives = 258/509 (50%), Gaps = 59/509 (11%)

Query: 1716 ITNLQPYTSYNVRVVVVYKTGENSTSLPESFKTKAGVPNKPGIPKL-LEGSKN---SIQW 1771
            +++L+P+ +Y   V    + G +      SF+T +   N+   PK+ LEG      S+ W
Sbjct: 399  VSDLEPHMNYTFTVEA--RNGVSGLVTSRSFRTASVSINQTEPPKVRLEGRSTTSLSVSW 456

Query: 1772 EKAEDNGCRITYYILEIRKSTSNNLQNQNLRWKMTFNGSCSSVCTWKSKNLKGIFQFRVV 1831
                    R+  Y +  RK   +N  + N+R    F+ +   +    +      +  +V 
Sbjct: 457  SIPPPQQSRVWKYEVTYRKKGDSN--SYNVRRTEGFSVTLDDLAPDTT------YLVQVQ 508

Query: 1832 AANNLGFGEYSGISENIILVGDDFWIPETSFILTIIVGI-----FLVVTIPLTFVWHRRL 1886
            A    G G  S + E   L       PE S  L +I G+      L+V   + F  HRR 
Sbjct: 509  ALTQEGQGAGSKVHEFQTLS------PEGSGNLAVIGGVAVGVVLLLVLAGVGFFIHRRR 562

Query: 1887 KNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTL--PTQEEIENLPAFPREK 1944
            KNQ++ +    V  ++ ++L  L+               HT   P Q  ++         
Sbjct: 563  KNQRARQSPEDVYFSKSEQLKPLKTYVDP----------HTYEDPNQAVLKFTTEIHPSC 612

Query: 1945 LTLRLLLGSGAFGEVYEGTAVDILGVGSG--EIKVAVKTLKKGSTDQEKIEFLKEAHLMS 2002
            +T + ++G+G FGEVY+G    +L   SG  E+ VA+KTLK G T++++++FL EA +M 
Sbjct: 613  VTRQKVIGAGEFGEVYKG----MLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMG 668

Query: 2003 KFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVD 2062
            +F+H NI++  GV    +P  II E ME G L  +LR+           +++ LV +   
Sbjct: 669  QFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGE------FSVLQLVGMLRG 722

Query: 2063 ISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKND---YYRKRG 2119
            I+ G  YL  M+++HRDLAARN LV+     S  + K+ DFGL+R + ++D    Y   G
Sbjct: 723  IAAGMKYLANMNYVHRDLAARNILVN-----SNLVCKVSDFGLSR-VLEDDPEATYTTSG 776

Query: 2120 EGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGR 2179
             G +P+RW APE++    FT+ SDVWSFGI++WE++T G +PY   SN +V+  +  G R
Sbjct: 777  -GKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFR 835

Query: 2180 LEPPRNCPDDLWNLMTQCWAQEPDQRPTF 2208
            L  P +CP  ++ LM QCW QE  +RP F
Sbjct: 836  LPTPMDCPSAIYQLMMQCWQQERARRPKF 864



 Score = 34.7 bits (78), Expect = 1.1
 Identities = 32/129 (24%), Positives = 50/129 (38%), Gaps = 8/129 (6%)

Query: 148 VSRPSYVVKPLHPFTEYIFRVVWIFTAQLQLYS-PPSPSYRTHPHGVPETAPLIRNIESS 206
           ++R S  V  L P   Y F V     A+  +     S S+RT    + +T P    +E  
Sbjct: 392 LTRTSVTVSDLEPHMNYTFTV----EARNGVSGLVTSRSFRTASVSINQTEPPKVRLEGR 447

Query: 207 SPDTVEVSWDPPQFPGGPILGYNLRLISKNQKLDAGTQRT---SFQFYSTLPNTIYRFSI 263
           S  ++ VSW  P      +  Y +    K        +RT   S       P+T Y   +
Sbjct: 448 STTSLSVSWSIPPPQQSRVWKYEVTYRKKGDSNSYNVRRTEGFSVTLDDLAPDTTYLVQV 507

Query: 264 AAVNEVGEG 272
            A+ + G+G
Sbjct: 508 QALTQEGQG 516


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.415 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 93,423,373
Number of Sequences: 37866
Number of extensions: 4407884
Number of successful extensions: 14794
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 289
Number of HSP's successfully gapped in prelim test: 563
Number of HSP's that attempted gapping in prelim test: 10158
Number of HSP's gapped (non-prelim): 3287
length of query: 2347
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2228
effective length of database: 13,741,464
effective search space: 30615981792
effective search space used: 30615981792
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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