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Search of human proteins with 19923493
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19923493 pleckstrin homology domain containing, family A
member 5 isoform 1 [Homo sapiens]
(1116 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19923493 pleckstrin homology domain containing, family A memb... 2252 0.0
gi|219689123 pleckstrin homology domain containing, family A mem... 1897 0.0
gi|239047795 pleckstrin homology domain containing, family A mem... 439 e-123
gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo ... 436 e-122
gi|238859653 pleckstrin homology domain containing family A memb... 143 8e-34
gi|238859651 pleckstrin homology domain containing family A memb... 143 8e-34
gi|41393057 connector enhancer of kinase suppressor of Ras 2 [Ho... 77 1e-13
gi|194733753 phosphoinositide-binding protein PIP3-E isoform 1 [... 71 7e-12
gi|194733747 phosphoinositide-binding protein PIP3-E isoform 1 [... 71 7e-12
gi|40354212 phosphoinositide-binding protein PIP3-E isoform 2 [H... 71 7e-12
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 62 3e-09
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 58 6e-08
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 57 1e-07
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform... 55 5e-07
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 55 5e-07
gi|155969695 membrane-associated guanylate kinase-related 3 iso... 55 5e-07
gi|50980301 myosin phosphatase-Rho interacting protein isoform 2... 55 5e-07
gi|50980307 myosin phosphatase-Rho interacting protein isoform 1... 55 5e-07
gi|34013590 Rho GTPase activating protein 2 [Homo sapiens] 55 5e-07
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa... 55 5e-07
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa... 54 1e-06
gi|11141889 WW45 protein [Homo sapiens] 53 1e-06
gi|222352183 neural precursor cell expressed, developmentally do... 53 2e-06
gi|21361472 neural precursor cell expressed, developmentally dow... 53 2e-06
gi|222352094 neural precursor cell expressed, developmentally do... 53 2e-06
gi|222352092 neural precursor cell expressed, developmentally do... 53 2e-06
gi|222352090 neural precursor cell expressed, developmentally do... 53 2e-06
gi|222352088 neural precursor cell expressed, developmentally do... 53 2e-06
gi|222352086 neural precursor cell expressed, developmentally do... 53 2e-06
gi|222352084 neural precursor cell expressed, developmentally do... 53 2e-06
>gi|19923493 pleckstrin homology domain containing, family A member 5
isoform 1 [Homo sapiens]
Length = 1116
Score = 2252 bits (5835), Expect = 0.0
Identities = 1116/1116 (100%), Positives = 1116/1116 (100%)
Query: 1 MAADLNLEWISLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPT 60
MAADLNLEWISLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPT
Sbjct: 1 MAADLNLEWISLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPT 60
Query: 61 GWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDNCIFVVNEQTVATMTSEEKKERPIS 120
GWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDNCIFVVNEQTVATMTSEEKKERPIS
Sbjct: 61 GWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDNCIFVVNEQTVATMTSEEKKERPIS 120
Query: 121 MINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQD 180
MINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQD
Sbjct: 121 MINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQD 180
Query: 181 STGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAH 240
STGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAH
Sbjct: 181 STGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAH 240
Query: 241 PNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSENAPTKETNNIPNHRVLI 300
PNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSENAPTKETNNIPNHRVLI
Sbjct: 241 PNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSENAPTKETNNIPNHRVLI 300
Query: 301 KPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEYESGSACP 360
KPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEYESGSACP
Sbjct: 301 KPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEYESGSACP 360
Query: 361 AQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRTNSMQQLEQWIKI 420
AQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRTNSMQQLEQWIKI
Sbjct: 361 AQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRTNSMQQLEQWIKI 420
Query: 421 QKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTRPESICSVTPSTH 480
QKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTRPESICSVTPSTH
Sbjct: 421 QKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTRPESICSVTPSTH 480
Query: 481 DKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVNISDQTMHS 540
DKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVNISDQTMHS
Sbjct: 481 DKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVNISDQTMHS 540
Query: 541 IPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPAG 600
IPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPAG
Sbjct: 541 IPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPAG 600
Query: 601 LTLQSVSPQSLQGKTLSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLH 660
LTLQSVSPQSLQGKTLSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLH
Sbjct: 601 LTLQSVSPQSLQGKTLSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLH 660
Query: 661 KEKYTLEQALLSASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWR 720
KEKYTLEQALLSASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWR
Sbjct: 661 KEKYTLEQALLSASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWR 720
Query: 721 EYDKLEYDVTVTRNQMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRG 780
EYDKLEYDVTVTRNQMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRG
Sbjct: 721 EYDKLEYDVTVTRNQMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRG 780
Query: 781 TTEIGMIGSKPFSTVKYKNEGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSVVK 840
TTEIGMIGSKPFSTVKYKNEGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSVVK
Sbjct: 781 TTEIGMIGSKPFSTVKYKNEGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSVVK 840
Query: 841 GSHFPVGVVPPRAKSPTPESSTIASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRPRM 900
GSHFPVGVVPPRAKSPTPESSTIASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRPRM
Sbjct: 841 GSHFPVGVVPPRAKSPTPESSTIASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRPRM 900
Query: 901 TVEEQMERIRRHQQACLREKKKGLNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDDKELD 960
TVEEQMERIRRHQQACLREKKKGLNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDDKELD
Sbjct: 901 TVEEQMERIRRHQQACLREKKKGLNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDDKELD 960
Query: 961 TAIRENDVKPDHETPATEIVQLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNSVEM 1020
TAIRENDVKPDHETPATEIVQLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNSVEM
Sbjct: 961 TAIRENDVKPDHETPATEIVQLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNSVEM 1020
Query: 1021 MDKERNKDKMPEDVTFSPQDETQTANHKPEEHPEENTKNSVDEQEETVISYESTPEVSRG 1080
MDKERNKDKMPEDVTFSPQDETQTANHKPEEHPEENTKNSVDEQEETVISYESTPEVSRG
Sbjct: 1021 MDKERNKDKMPEDVTFSPQDETQTANHKPEEHPEENTKNSVDEQEETVISYESTPEVSRG 1080
Query: 1081 NQTMAVKSLSPSPESSASPVPSTQPQLTEGSHFMCV 1116
NQTMAVKSLSPSPESSASPVPSTQPQLTEGSHFMCV
Sbjct: 1081 NQTMAVKSLSPSPESSASPVPSTQPQLTEGSHFMCV 1116
>gi|219689123 pleckstrin homology domain containing, family A member 5
isoform 2 [Homo sapiens]
Length = 1105
Score = 1897 bits (4915), Expect = 0.0
Identities = 981/1110 (88%), Positives = 986/1110 (88%), Gaps = 107/1110 (9%)
Query: 109 MTSEEKKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNA 168
MTSEEKKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNA
Sbjct: 1 MTSEEKKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNA 60
Query: 169 PVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSED 228
PVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSED
Sbjct: 61 PVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSED 120
Query: 229 HINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSENAPTK 288
HINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSENAPTK
Sbjct: 121 HINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSENAPTK 180
Query: 289 ETNNIPNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNS 348
ETNNIPNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNS
Sbjct: 181 ETNNIPNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNS 240
Query: 349 LPSEYESGSACPAQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRT 408
LPSEYESGSACPAQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRT
Sbjct: 241 LPSEYESGSACPAQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRT 300
Query: 409 NSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTR 468
NSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTR
Sbjct: 301 NSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTR 360
Query: 469 PESICSVTPSTHDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPK 528
PESICSVTPSTHDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPK
Sbjct: 361 PESICSVTPSTHDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPK 420
Query: 529 TMVNISDQTMHSIPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKH 588
TMVNISDQTMHSIPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKH
Sbjct: 421 TMVNISDQTMHSIPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKH 480
Query: 589 VYVPDRRSVPAGLTLQSVSPQSLQGKT--------------------------------- 615
VYVPDRRSVPAGLTLQSVSPQSLQGKT
Sbjct: 481 VYVPDRRSVPAGLTLQSVSPQSLQGKTMKENEPIITMVHTMIENSALRPQLYQQFLRQKS 540
Query: 616 ------LSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQA 669
LSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQA
Sbjct: 541 KISLYCLSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQA 600
Query: 670 LLSASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDV 729
LLSASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDV
Sbjct: 601 LLSASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDV 660
Query: 730 TVTRNQMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGTTEIGMIGS 789
TVTRNQMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQR GMIGS
Sbjct: 661 TVTRNQMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQR-----GMIGS 715
Query: 790 KPFSTVKYKNEG----------PDYRLYKSEPELTTVAEVDES----------------- 822
KPFSTVKYKNE P + +P + D S
Sbjct: 716 KPFSTVKYKNEEEEVVPPRPPLPRSYDFTEQPPIIPPLPSDSSSLLCYSRGPVHLPEEKK 775
Query: 823 ---------NGEE--------KSEP----VSEI---------------ETSVVKGSHFPV 846
NG KSEP V+E+ ETSVVKGSHFPV
Sbjct: 776 MYQVQGYPRNGSHCGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSVVKGSHFPV 835
Query: 847 GVVPPRAKSPTPESSTIASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRPRMTVEEQM 906
GVVPPRAKSPTPESSTIASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRPRMTVEEQM
Sbjct: 836 GVVPPRAKSPTPESSTIASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRPRMTVEEQM 895
Query: 907 ERIRRHQQACLREKKKGLNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDDKELDTAIREN 966
ERIRRHQQACLREKKKGLNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDDKELDTAIREN
Sbjct: 896 ERIRRHQQACLREKKKGLNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDDKELDTAIREN 955
Query: 967 DVKPDHETPATEIVQLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNSVEMMDKERN 1026
DVKPDHETPATEIVQLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNSVEMMDKERN
Sbjct: 956 DVKPDHETPATEIVQLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNSVEMMDKERN 1015
Query: 1027 KDKMPEDVTFSPQDETQTANHKPEEHPEENTKNSVDEQEETVISYESTPEVSRGNQTMAV 1086
KDKMPEDVTFSPQDETQTANHKPEEHPEENTKNSVDEQEETVISYESTPEVSRGNQTMAV
Sbjct: 1016 KDKMPEDVTFSPQDETQTANHKPEEHPEENTKNSVDEQEETVISYESTPEVSRGNQTMAV 1075
Query: 1087 KSLSPSPESSASPVPSTQPQLTEGSHFMCV 1116
KSLSPSPESSASPVPSTQPQLTEGSHFMCV
Sbjct: 1076 KSLSPSPESSASPVPSTQPQLTEGSHFMCV 1105
>gi|239047795 pleckstrin homology domain containing, family A member
7 [Homo sapiens]
Length = 1121
Score = 439 bits (1129), Expect = e-123
Identities = 304/843 (36%), Positives = 437/843 (51%), Gaps = 101/843 (11%)
Query: 11 SLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPTGWEEAYTFEG 70
+LP W+YG+ R GRVFFIN++ + TTWLHP TGE V +GH +S DLP GWEE +T EG
Sbjct: 10 TLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIRS-DLPRGWEEGFTEEG 68
Query: 71 ARYYINHNERKVTCKHPVTGQPSQDNCIFVVNEQTVATMTSEEKKERPISMINEASNYNV 130
A Y+I+HN++ +HPVTGQ S +N F++ E+ M+ +++ +RP SM++E S
Sbjct: 69 ASYFIDHNQQTTAFRHPVTGQFSPENSEFILQEEPNPHMSKQDRNQRPSSMVSETSTAGT 128
Query: 131 TSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQDSTGMKLWKKR 190
S P + ++S KVH+FGKR +I+RNPN PVV RGWL+KQDS+GM+LWK+R
Sbjct: 129 ASTLEAKPGPKI---IKSSSKVHSFGKRDQAIRRNPNVPVVVRGWLHKQDSSGMRLWKRR 185
Query: 191 WFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAH---------- 240
WFVL+D CLFYY+D +EE +LGSI LPS+ I+ + ED I+RKY+FKA H
Sbjct: 186 WFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRALIYNS 245
Query: 241 ---------PNMRTYYFCTDTGKEMELWMKAMLDAA-LVQTEPVKR-VDKITSENAPTKE 289
MRTYYF DT ++M W++AM AA ++ +KR ++K+ + P
Sbjct: 246 STAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQVLSRSSLKRDMEKVERQAVPQAN 305
Query: 290 TNNIPNHRVLIKPEIQNNQKNKEMSKIE--EKKALEAEKYGFQKDGQDRPLT-KINSVKL 346
+ + P + ++ I E++ E E+Y Q+D PL K + K
Sbjct: 306 HTESCHECGRVGPGHTRDCPHRGHDDIVNFERQEQEGEQYRSQRD----PLEGKRDRSKA 361
Query: 347 NSLPSEYESGSACPAQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTG------PLYTE 400
S S E + R + + A G + TG P T
Sbjct: 362 RSPYSPAEEDALFMDLPTGPRGQQAQPQRAEKNGMLPASYGPGEQNGTGGYQRAFPPRTN 421
Query: 401 ADRVIQRTNSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRT 460
++ QR +++ Q+E W + QKG ++R + QTLPR P +PE Y+T
Sbjct: 422 PEKHSQRKSNLAQVEHWARAQKG-----DSRSLPLDQTLPRQGPGQSLS----FPENYQT 472
Query: 461 LPRN-------SKTRPESICSVTPSTHDKTLG-PGAEEKRRSMRDDTMWQLYEWQQR-QF 511
LP++ S P ++ S D+ + E+RR+ RD T+WQLYEWQQR QF
Sbjct: 473 LPKSTRHPSGGSSPPPRNLPSDYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQF 532
Query: 512 YNKQSTLPRHSTLSSPKTMVNISDQTMHSIPTS----PSHGSI---AAYQGYSPQRTY-- 562
+ T P L SP+ ++M +P S PS I + + P+R +
Sbjct: 533 RHGSPTAP--ICLGSPEFTDQGRSRSMLEVPRSISVPPSPSDIPPPGPPRVFPPRRPHTP 590
Query: 563 --RSEVSSPIQRGDVTID-----RRHRAHHPKHVYVPDRRSVPA-GLTLQSVSPQSLQGK 614
R V P QR V I RR R H K+ DRRS+P+ G +VS SL GK
Sbjct: 591 AERVTVKPPDQRRSVDISLGDSPRRARGHAVKNSSHVDRRSMPSMGYMTHTVSAPSLHGK 650
Query: 615 T-------LSQD--------EGRG-----TLYKYRPEEVDIDAKLSRLCEQDKVVHALEE 654
+ L +D GR +L + E D D KLS CEQD+V+ LE+
Sbjct: 651 SADDTYLQLKKDLEYLDLKMTGRDLLKDRSLKPVKIAESDTDVKLSIFCEQDRVLQDLED 710
Query: 655 KLQQLHKEKYTLEQALLSASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAE 714
K++ L + K LE L +++E + D P ++ + Q+ LQ L+ ELSR + E
Sbjct: 711 KIRALKENKDQLESVLEVLHRQMEQYRDQPQHLEKIAYQQKLLQEDLVHIRAELSRESTE 770
Query: 715 LERAWREYDKLEYDVTVTRNQMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSK 774
+E AW EY KLE DV + +QEQ Q +++QIQK+LWRI+DV GLS
Sbjct: 771 MENAWNEYLKLENDVEQLKQTLQEQHRRAFFFQ------EKSQIQKDLWRIEDVTAGLSA 824
Query: 775 HKQ 777
+K+
Sbjct: 825 NKE 827
Score = 63.5 bits (153), Expect = 1e-09
Identities = 44/124 (35%), Positives = 66/124 (53%), Gaps = 10/124 (8%)
Query: 803 DYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSVVKGSHFPVGVVPPRAKSPTPESST 862
+ R Y SEPEL T++ P S +T +G + S +SST
Sbjct: 980 ELRSYVSEPELATLSGDMAQPSLGLVGPESRYQTLPGRGLS--------GSTSRLQQSST 1031
Query: 863 IASYVTLRKTKKMMDLRTE--RPRSAVEQLCLAESTRPRMTVEEQMERIRRHQQACLREK 920
IA YVTLR+ + RP+SA+E+L + R +M+ EEQ+ER++RHQ+A +RE+
Sbjct: 1032 IAPYVTLRRGLNAESSKATFPRPKSALERLYSGDHQRGKMSAEEQLERMKRHQKALVRER 1091
Query: 921 KKGL 924
K+ L
Sbjct: 1092 KRTL 1095
>gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo
sapiens]
Length = 1048
Score = 436 bits (1122), Expect = e-122
Identities = 346/1087 (31%), Positives = 528/1087 (48%), Gaps = 138/1087 (12%)
Query: 109 MTSEEKKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNA 168
M+++ +RP + ++ N+N+ S+ V P P R +R ++K FGKRS+S+KRNPNA
Sbjct: 1 MSNKTGGKRPATTNSDIPNHNMVSE--VPPERPSVRATRTARKAVAFGKRSHSMKRNPNA 58
Query: 169 PVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSED 228
PV + GWL+KQ S+G+K W KRWFVL D CLFYY+DEKEE ILGSI L SF++A + D
Sbjct: 59 PVTKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSD 118
Query: 229 HINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRV---------DK 279
+I+RK+ FKA H +RTY+F ++ +E E W++AM +AA VQ P ++ +K
Sbjct: 119 NISRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQAVRHSHEK 178
Query: 280 ITSENAPTKETNNIPNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLT 339
SEN P + + P H L KPE + + + + EK E+ +K+ P
Sbjct: 179 PDSENVPPSKHHQQPPHNSLPKPEPEAKTRGEGDGRGCEKAERRPERPEVKKE----PPV 234
Query: 340 KINSVKLNSLP-----SEYESGSACPAQTVHYRPIN----LSSSENKIVNVSLADLRGGN 390
K N + P S Y G P N S S D G
Sbjct: 235 KANGLPAGPEPASEPGSPYPEGPRVPGGGEQPAQPNGWQYHSPSRPGSTAFPSQDGETGG 294
Query: 391 RPNTGPLYTEADRVIQRTNSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQI 450
+ P T D++ QR +SM QL+QW+ +++G E+ R + + R +P +
Sbjct: 295 HRRSFPPRTNPDKIAQRKSSMNQLQQWVNLRRGVPPPEDLRSPSRFYPVSRRVPEYYGPY 354
Query: 451 MARYPEGYRTLPRNSKTRPESICSVTPSTHDKTLGPGA-EEKRRSMRD--DTMWQLYEWQ 507
++YP+ Y+ P RPESICS+ +D+ P A E+KR + R+ +QL EW+
Sbjct: 355 SSQYPDDYQYYPPG--VRPESICSM--PAYDRISPPWALEDKRHAFRNGGGPAYQLREWK 410
Query: 508 QRQFYNKQST---LPRHS----------TLSSPKTMVNISDQTMHSIPTSPSHGSIAAYQ 554
+ Y +Q +P S SS +++ ++ HS+P SPS GS + +
Sbjct: 411 EPASYGRQDATVWIPSPSRQPVYYDELDAASSSLRRLSLQPRS-HSVPRSPSQGSYSRAR 469
Query: 555 GYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPAGLTLQSVSPQSLQGK 614
YSP V SP R + R + YV RRS+ + V P
Sbjct: 470 IYSP-------VRSPSARFERLPPRSEDIYADPAAYVM-RRSISS----PKVPPY----- 512
Query: 615 TLSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQALLSAS 674
+ R +L+ Y+ E D D L +LCEQ+KVV + +QQL EK +LE AL+
Sbjct: 513 ---PEVFRDSLHTYKLNEQDTDKLLGKLCEQNKVVREQDRLVQQLRAEKESLESALMGTH 569
Query: 675 QEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRN 734
QE+EM PA + + ++D LQN L++ ELS+AT L + EY+ LE +V+ +
Sbjct: 570 QELEMFGSQPAYPEKLRHKKDSLQNQLINIRVELSQATTALTNSTIEYEHLESEVSALHD 629
Query: 735 QMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGTTEIGMIGS----- 789
+ EQL+ + T++ + R QIQKE+WRIQDVMEGL K+ RGT G
Sbjct: 630 DLWEQLN----LDTQNEVLNR-QIQKEIWRIQDVMEGLRKNNPSRGTDTAKHRGGLGPSA 684
Query: 790 --------------------KPFSTVKYKNEGP----------DYRLYKSEPELTTVAEV 819
PFS V P +Y K +P T +
Sbjct: 685 TYSSNSPASPLSSASLTSPLSPFSLVSGSQGSPTKPGSNEPKANYEQSKKDPHQTLPLDT 744
Query: 820 --DESNGEEKSEPVSEIETSVVKGSHFPVGVVPPRAKSPTPESSTIASYVTLRKTKKMMD 877
D S + E +E + ++ K VGVVPPR KSPT + T ++ V +
Sbjct: 745 PRDISLVPTRQEVEAEKQAALNK-----VGVVPPRTKSPTDDEVTPSAVVRRNASGLTNG 799
Query: 878 LRT-ERPRSAVEQLCLAESTRPRMTVEEQMERIRRHQQACLREKKKGLNVIGASDQSPLQ 936
L + ERP+SAV + +M+VEEQ++R+RRHQ +REK++ L + SP
Sbjct: 800 LSSQERPKSAV----FPGEGKVKMSVEEQIDRMRRHQSGSMREKRRSLQL----PASPAP 851
Query: 937 SPSNLRDNPFRTTQTRRRDDKELDTAIRENDVKPD------HETPATEIVQLK--ETEPQ 988
PS P R R E+D + E ++ + +ETP EI +L+ E EPQ
Sbjct: 852 DPS---PRPAYKVVRRHRSIHEVDISNLEAALRAEEPGGHAYETPREEIARLRKMELEPQ 908
Query: 989 --NVDFSKELKKTENISY-EMLFEPEPN-GVNSVEMMDKERNKDKMPEDVTFSPQDETQT 1044
+VD +KEL + + E + EP+ ++ E+ +K++ +++ + S
Sbjct: 909 HYDVDINKELSTPDKVLIPERYIDLEPDTPLSPEELKEKQKKVERIKTLIAKSSMQNVVP 968
Query: 1045 ANHKPEEHPEENTKNSVDEQEETV-ISYESTPEVSRGNQTMAVKSLSPSPESS-ASPVPS 1102
+++++ + EQE+ + IS E SR + ++V+ +PSP +S ASP P
Sbjct: 969 IGEGDSVDVPQDSESQLQEQEKRIEISCALATEASRRGRMLSVQCATPSPPTSPASPAPP 1028
Query: 1103 TQPQLTE 1109
P +E
Sbjct: 1029 ANPLSSE 1035
>gi|238859653 pleckstrin homology domain containing family A member
4 isoform 2 [Homo sapiens]
Length = 583
Score = 143 bits (361), Expect = 8e-34
Identities = 69/147 (46%), Positives = 101/147 (68%), Gaps = 3/147 (2%)
Query: 117 RPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWL 176
RP S ++ AS+ + S ++ +SP + +RA K+H FGKR N+++R+PN PV RGWL
Sbjct: 5 RPRSSLSLASSASTIS--SLSSLSPK-KPTRAVNKIHAFGKRGNALRRDPNLPVHIRGWL 61
Query: 177 YKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAF 236
+KQDS+G++LWK+RWFVLS CLFYY+D +EE +LGS+LLPS+ I R++ F
Sbjct: 62 HKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFTF 121
Query: 237 KAAHPNMRTYYFCTDTGKEMELWMKAM 263
A HP MRTY DT +++ W++A+
Sbjct: 122 TAEHPGMRTYVLAADTLEDLRGWLRAL 148
Score = 68.9 bits (167), Expect = 2e-11
Identities = 46/153 (30%), Positives = 74/153 (48%), Gaps = 7/153 (4%)
Query: 631 EEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQALLSASQEIEMHADNPAAIQTV 690
+ ++ D L++LC QD+++ L+E++ Q +EK LE AL Q++ A
Sbjct: 335 QSLETDTLLTKLCGQDRLLRRLQEEIDQKQEEKEQLEAALELTRQQLGQATREAGAPGRA 394
Query: 691 VLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRNQMQEQLDHLGEVQTES 750
++ LQ+ L+S L T E ER W Y LE ++ R + E L HLG Q
Sbjct: 395 WGRQRLLQDRLVSVRATLCHLTQERERVWDTYSGLEQELGTLRETL-EYLLHLGSPQ--- 450
Query: 751 AGIQRAQIQKELWRIQDVMEGLSKHKQQRGTTE 783
R Q++LW ++D + GL ++ TE
Sbjct: 451 ---DRVSAQQQLWMVEDTLAGLGGPQKPPPHTE 480
>gi|238859651 pleckstrin homology domain containing family A member
4 isoform 1 [Homo sapiens]
Length = 779
Score = 143 bits (361), Expect = 8e-34
Identities = 69/147 (46%), Positives = 101/147 (68%), Gaps = 3/147 (2%)
Query: 117 RPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWL 176
RP S ++ AS+ + S ++ +SP + +RA K+H FGKR N+++R+PN PV RGWL
Sbjct: 5 RPRSSLSLASSASTIS--SLSSLSPK-KPTRAVNKIHAFGKRGNALRRDPNLPVHIRGWL 61
Query: 177 YKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAF 236
+KQDS+G++LWK+RWFVLS CLFYY+D +EE +LGS+LLPS+ I R++ F
Sbjct: 62 HKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFTF 121
Query: 237 KAAHPNMRTYYFCTDTGKEMELWMKAM 263
A HP MRTY DT +++ W++A+
Sbjct: 122 TAEHPGMRTYVLAADTLEDLRGWLRAL 148
Score = 77.4 bits (189), Expect = 7e-14
Identities = 73/285 (25%), Positives = 118/285 (41%), Gaps = 42/285 (14%)
Query: 631 EEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQALLSASQEIEMHADNPAAIQTV 690
+ ++ D L++LC QD+++ L+E++ Q +EK LE AL Q++ A
Sbjct: 360 QSLETDTLLTKLCGQDRLLRRLQEEIDQKQEEKEQLEAALELTRQQLGQATREAGAPGRA 419
Query: 691 VLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRNQMQEQLDHLGEVQTES 750
++ LQ+ L+S L T E ER W Y LE ++ R + E L HLG Q
Sbjct: 420 WGRQRLLQDRLVSVRATLCHLTQERERVWDTYSGLEQELGTLRETL-EYLLHLGSPQ--- 475
Query: 751 AGIQRAQIQKELWRIQDVMEGLSKHKQQRGTTEIGMIGSKPFSTVKYKNEGPDYRLYKSE 810
R Q++LW ++D + GL GP +E
Sbjct: 476 ---DRVSAQQQLWMVEDTLAGLG---------------------------GPQKPPPHTE 505
Query: 811 PELTTVAEVDESNGEEKSEPVSEIETSVVKGSHFPVGVVPPRAKSPTPESSTIASYVTLR 870
P+ + E + E +S P S +E S + G + P + + ++ L
Sbjct: 506 PDSPSPVLQGEESSERESLPES-LELSSPRSPETDWG------RPPGGDKDLASPHLGLG 558
Query: 871 KTKKMMDLRTERPRSAVEQL-CLAESTRPRMTVEEQMERIRRHQQ 914
+ E QL A RPRM+ +EQ+ER+RR+Q+
Sbjct: 559 SPRVSRASSPEGRHLPSPQLGTKAPVARPRMSAQEQLERMRRNQE 603
>gi|41393057 connector enhancer of kinase suppressor of Ras 2 [Homo
sapiens]
Length = 1034
Score = 76.6 bits (187), Expect = 1e-13
Identities = 53/170 (31%), Positives = 79/170 (46%), Gaps = 10/170 (5%)
Query: 131 TSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQD---STGMKLW 187
T+ Y S + S+ K GK I GWL+K+ S + W
Sbjct: 532 TTLYHTFQQSSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKW 591
Query: 188 KKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAHPNMRTYY 247
KK WFVL D L++Y +E++E G I LP F+I +KYAFKA HP ++++Y
Sbjct: 592 KKYWFVLKDASLYWYINEEDEKAEGFISLPEFKI---DRASECRKKYAFKACHPKIKSFY 648
Query: 248 FCTDTGKEMELWMKA--MLDAALVQTEPVKRVDKITSENAPTKETNNIPN 295
F + +M W+ ML A + E +K+ SE+ KE + P+
Sbjct: 649 FAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSES--DKEEADTPS 696
>gi|194733753 phosphoinositide-binding protein PIP3-E isoform 1
[Homo sapiens]
Length = 438
Score = 70.9 bits (172), Expect = 7e-12
Identities = 36/115 (31%), Positives = 63/115 (54%), Gaps = 7/115 (6%)
Query: 173 RGWLYKQDSTGMKL---WKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDH 229
+GWLYK+ G L WKK W +L L++Y ++ E G + LP F + +
Sbjct: 46 QGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASE--- 102
Query: 230 INRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSEN 284
+K+AFK +HP ++T+YF + +EM +W+ L +A++ E + ++ SE+
Sbjct: 103 CKKKHAFKISHPQIKTFYFAAENVQEMNVWLN-KLGSAVIHQESTTKDEECYSES 156
>gi|194733747 phosphoinositide-binding protein PIP3-E isoform 1
[Homo sapiens]
Length = 438
Score = 70.9 bits (172), Expect = 7e-12
Identities = 36/115 (31%), Positives = 63/115 (54%), Gaps = 7/115 (6%)
Query: 173 RGWLYKQDSTGMKL---WKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDH 229
+GWLYK+ G L WKK W +L L++Y ++ E G + LP F + +
Sbjct: 46 QGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASE--- 102
Query: 230 INRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSEN 284
+K+AFK +HP ++T+YF + +EM +W+ L +A++ E + ++ SE+
Sbjct: 103 CKKKHAFKISHPQIKTFYFAAENVQEMNVWLN-KLGSAVIHQESTTKDEECYSES 156
>gi|40354212 phosphoinositide-binding protein PIP3-E isoform 2 [Homo
sapiens]
Length = 437
Score = 70.9 bits (172), Expect = 7e-12
Identities = 36/115 (31%), Positives = 63/115 (54%), Gaps = 7/115 (6%)
Query: 173 RGWLYKQDSTGMKL---WKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDH 229
+GWLYK+ G L WKK W +L L++Y ++ E G + LP F + +
Sbjct: 45 QGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASE--- 101
Query: 230 INRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSEN 284
+K+AFK +HP ++T+YF + +EM +W+ L +A++ E + ++ SE+
Sbjct: 102 CKKKHAFKISHPQIKTFYFAAENVQEMNVWLN-KLGSAVIHQESTTKDEECYSES 155
>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1
[Homo sapiens]
Length = 922
Score = 62.0 bits (149), Expect = 3e-09
Identities = 34/93 (36%), Positives = 44/93 (47%), Gaps = 6/93 (6%)
Query: 1 MAADLNLEWISLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPT 60
M A N + LP W + RV+F+N K+T W P T + LP
Sbjct: 447 MLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGL------QNEEPLPE 500
Query: 61 GWEEAYTFEGARYYINHNERKVTCKHPVTGQPS 93
GWE YT EG RY+++HN R T K P G+ S
Sbjct: 501 GWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSS 533
Score = 42.4 bits (98), Expect = 0.002
Identities = 21/77 (27%), Positives = 31/77 (40%), Gaps = 14/77 (18%)
Query: 11 SLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPTGWEEAYTFEG 70
+LP W GR ++++ ++TTW P LP GWE
Sbjct: 350 TLPSGWEQRKDPHGRTYYVDHNTRTTTWERP--------------QPLPPGWERRVDDRR 395
Query: 71 ARYYINHNERKVTCKHP 87
YY++HN R T + P
Sbjct: 396 RVYYVDHNTRTTTWQRP 412
Score = 30.8 bits (68), Expect = 7.5
Identities = 13/38 (34%), Positives = 21/38 (55%)
Query: 12 LPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVT 49
LP W TR G +F++ ++TT+ P G++ VT
Sbjct: 498 LPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVT 535
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 57.8 bits (138), Expect = 6e-08
Identities = 27/67 (40%), Positives = 36/67 (53%), Gaps = 6/67 (8%)
Query: 24 GRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPTGWEEAYTFEGARYYINHNERKVT 83
GRV+++N ++T W P T + Q LP GWE YT EG RY+++HN R T
Sbjct: 418 GRVYYVNHNTRTTQWEDPRTQGMI------QEPALPPGWEMKYTSEGVRYFVDHNTRTTT 471
Query: 84 CKHPVTG 90
K P G
Sbjct: 472 FKDPRPG 478
Score = 48.5 bits (114), Expect = 3e-05
Identities = 24/77 (31%), Positives = 34/77 (44%), Gaps = 16/77 (20%)
Query: 11 SLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPTGWEEAYTFEG 70
+LP W GRV++++ K+TTW P LP GWE+ G
Sbjct: 301 ALPAGWEQRELPNGRVYYVDHNTKTTTWERP----------------LPPGWEKRTDPRG 344
Query: 71 ARYYINHNERKVTCKHP 87
YY++HN R T + P
Sbjct: 345 RFYYVDHNTRTTTWQRP 361
Score = 33.1 bits (74), Expect = 1.5
Identities = 43/204 (21%), Positives = 76/204 (37%), Gaps = 40/204 (19%)
Query: 58 LPTGWEEAYTFEGARYYINHNERKVTCKHPV----TGQPSQDNCIFVVNEQTVATMTSEE 113
LP GWE+ G YY++HN + T + P+ + + V+ T T
Sbjct: 302 LPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVDHNTRTTTW--- 358
Query: 114 KKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKR------SNSIKRNPN 167
+RP T++Y + + ++ + +F +R S S +P
Sbjct: 359 --QRP------------TAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPL 404
Query: 168 APVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSE 227
P + GW +QD+ + ++V + + D + +G++ LP TSE
Sbjct: 405 GP-LPPGWEKRQDN------GRVYYVNHNTRTTQWEDPRTQGMIQEPALPPGWEMKYTSE 457
Query: 228 ------DHINRKYAFKAAHPNMRT 245
DH R FK P +
Sbjct: 458 GVRYFVDHNTRTTTFKDPRPGFES 481
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo
sapiens]
Length = 862
Score = 57.0 bits (136), Expect = 1e-07
Identities = 28/85 (32%), Positives = 40/85 (47%), Gaps = 6/85 (7%)
Query: 12 LPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPTGWEEAYTFEGA 71
LP W GRV+F+N + T W P + + LP GWE +T +G
Sbjct: 399 LPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQL------NEKPLPEGWEMRFTVDGI 452
Query: 72 RYYINHNERKVTCKHPVTGQPSQDN 96
Y+++HN R T P TG+ + DN
Sbjct: 453 PYFVDHNRRTTTYIDPRTGKSALDN 477
Score = 44.3 bits (103), Expect = 7e-04
Identities = 23/76 (30%), Positives = 32/76 (42%), Gaps = 14/76 (18%)
Query: 12 LPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPTGWEEAYTFEGA 71
LP W + + GRV++++ K TTW P LP GWE G
Sbjct: 287 LPPGWEQRVDQHGRVYYVDHVEKRTTWDRP--------------EPLPPGWERRVDNMGR 332
Query: 72 RYYINHNERKVTCKHP 87
YY++H R T + P
Sbjct: 333 IYYVDHFTRTTTWQRP 348
>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
[Homo sapiens]
Length = 1045
Score = 54.7 bits (130), Expect = 5e-07
Identities = 24/87 (27%), Positives = 44/87 (50%), Gaps = 1/87 (1%)
Query: 187 WKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAHPNMRTY 246
W+K W V ++ CLF+Y+ ++ L S+ L + + + + ++I + Y FK H Y
Sbjct: 949 WQKLWVVFTNFCLFFYKSHQDNHPLASLPLLGYSLTIPSESENIQKDYVFK-LHFKSHVY 1007
Query: 247 YFCTDTGKEMELWMKAMLDAALVQTEP 273
YF ++ E WM+ + A + P
Sbjct: 1008 YFRAESEYTFERWMEVIRSATSSASRP 1034
>gi|218505835 membrane-associated guanylate kinase-related 3
isoform 1 [Homo sapiens]
Length = 1481
Score = 54.7 bits (130), Expect = 5e-07
Identities = 28/88 (31%), Positives = 44/88 (50%), Gaps = 2/88 (2%)
Query: 1 MAADLNLEWISLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPT 60
M D LE LP++W T G ++FI+ K+TTWL P + + +LP
Sbjct: 286 MMRDETLE--PLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPY 343
Query: 61 GWEEAYTFEGARYYINHNERKVTCKHPV 88
GWE+ + YY++H +K ++PV
Sbjct: 344 GWEKIEDPQYGTYYVDHLNQKTQFENPV 371
>gi|155969695 membrane-associated guanylate kinase-related 3
isoform 2 [Homo sapiens]
Length = 1125
Score = 54.7 bits (130), Expect = 5e-07
Identities = 28/88 (31%), Positives = 44/88 (50%), Gaps = 2/88 (2%)
Query: 1 MAADLNLEWISLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPT 60
M D LE LP++W T G ++FI+ K+TTWL P + + +LP
Sbjct: 286 MMRDETLE--PLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPY 343
Query: 61 GWEEAYTFEGARYYINHNERKVTCKHPV 88
GWE+ + YY++H +K ++PV
Sbjct: 344 GWEKIEDPQYGTYYVDHLNQKTQFENPV 371
>gi|50980301 myosin phosphatase-Rho interacting protein isoform 2
[Homo sapiens]
Length = 1025
Score = 54.7 bits (130), Expect = 5e-07
Identities = 67/281 (23%), Positives = 104/281 (37%), Gaps = 55/281 (19%)
Query: 133 DYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQDSTGMKLWKKRWF 192
D + P+SP ++ + +RS P+ ++GWL KQ G WKK WF
Sbjct: 358 DASASPLSP-------HRRAKSLDRRSTEPSVTPDLLNFKKGWLTKQYEDGQ--WKKHWF 408
Query: 193 VLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAHPNMRTYYFCTDT 252
VL+D L YYRD E + A L E ++ Y +P R Y F T
Sbjct: 409 VLADQSLRYYRDSVAE-----------EAADLDGEIDLSACYDV-TEYPVQRNYGFQIHT 456
Query: 253 GKEMELWMKAMLDAALVQTEPVKRVDKITSENAPTKETNNIPNHRVLIKPEIQNNQKNKE 312
KE E + AM ++ ++ + K T+++P +KNK
Sbjct: 457 -KEGEFTLSAMTSG--IRRNWIQTIMKHVHPTTAPDVTSSLP------------EEKNKS 501
Query: 313 MSKIE------EKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEYESGSACPAQTVHY 366
E EK+ E G+ P K + + G + +
Sbjct: 502 SCSFETCPRPTEKQEAEL--------GEPDPEQKRSRAR-----ERRREGRSKTFDWAEF 548
Query: 367 RPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQR 407
RPI + ++ ++ V AD RP P E +R +R
Sbjct: 549 RPIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRR 589
>gi|50980307 myosin phosphatase-Rho interacting protein isoform 1
[Homo sapiens]
Length = 1038
Score = 54.7 bits (130), Expect = 5e-07
Identities = 67/281 (23%), Positives = 104/281 (37%), Gaps = 55/281 (19%)
Query: 133 DYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQDSTGMKLWKKRWF 192
D + P+SP ++ + +RS P+ ++GWL KQ G WKK WF
Sbjct: 358 DASASPLSP-------HRRAKSLDRRSTEPSVTPDLLNFKKGWLTKQYEDGQ--WKKHWF 408
Query: 193 VLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAHPNMRTYYFCTDT 252
VL+D L YYRD E + A L E ++ Y +P R Y F T
Sbjct: 409 VLADQSLRYYRDSVAE-----------EAADLDGEIDLSACYDV-TEYPVQRNYGFQIHT 456
Query: 253 GKEMELWMKAMLDAALVQTEPVKRVDKITSENAPTKETNNIPNHRVLIKPEIQNNQKNKE 312
KE E + AM ++ ++ + K T+++P +KNK
Sbjct: 457 -KEGEFTLSAMTSG--IRRNWIQTIMKHVHPTTAPDVTSSLP------------EEKNKS 501
Query: 313 MSKIE------EKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEYESGSACPAQTVHY 366
E EK+ E G+ P K + + G + +
Sbjct: 502 SCSFETCPRPTEKQEAEL--------GEPDPEQKRSRAR-----ERRREGRSKTFDWAEF 548
Query: 367 RPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQR 407
RPI + ++ ++ V AD RP P E +R +R
Sbjct: 549 RPIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRR 589
>gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]
Length = 698
Score = 54.7 bits (130), Expect = 5e-07
Identities = 44/140 (31%), Positives = 65/140 (46%), Gaps = 16/140 (11%)
Query: 139 MSP-VGRTSRASKKVHNFGKRSNSIKRNPN----APVVRRGWLYKQDSTGMKLWKKRWFV 193
+SP + + RA K G++S S R P PV++ GWL KQ S MK W++RWFV
Sbjct: 2 LSPKIRQARRARSKSLVMGEQSRSPGRMPCPHRLGPVLKAGWLKKQRSI-MKNWQQRWFV 60
Query: 194 LSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAA----------HPNM 243
L LFYY+D+ E G I L Q+ L K+ F+ + N
Sbjct: 61 LRGDQLFYYKDKDEIKPQGFISLQGTQVTELPPGPEDPGKHLFEISPGGAGEREKVPANP 120
Query: 244 RTYYFCTDTGKEMELWMKAM 263
+ ++ME W++A+
Sbjct: 121 EALLLMASSQRDMEDWVQAI 140
>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
sapiens]
Length = 1054
Score = 54.7 bits (130), Expect = 5e-07
Identities = 41/169 (24%), Positives = 76/169 (44%), Gaps = 15/169 (8%)
Query: 104 QTVATMTSEEKKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIK 163
+TV T E + +E V S H RA+ +H R+ S+
Sbjct: 867 RTVCTRPPRSPNEVSLEQESEDDARGVRSSLEGHGQH------RANTTMHVCWYRNTSVS 920
Query: 164 RNPNAPVVRR---GWLYKQ--DSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPS 218
R ++ V G+L ++ +S G W+K W V ++ CLF+Y+ +++ L S+ L
Sbjct: 921 RADHSAAVENQLSGYLLRKFKNSHG---WQKLWVVFTNFCLFFYKTHQDDYPLASLPLLG 977
Query: 219 FQIALLTSEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAA 267
+ +++ D I++ Y FK + Y+F ++ E WM+ + A+
Sbjct: 978 YSVSIPREADGIHKDYVFKLQFKS-HVYFFRAESKYTFERWMEVIQGAS 1025
>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
sapiens]
Length = 748
Score = 53.5 bits (127), Expect = 1e-06
Identities = 31/101 (30%), Positives = 49/101 (48%), Gaps = 9/101 (8%)
Query: 171 VRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHI 230
++ GWL KQ +K W RWFVL L+Y++DE E LG+I LP +++ +
Sbjct: 21 IKCGWLRKQGGF-VKTWHTRWFVLKGDQLYYFKDEDETKPLGTIFLPGNKVSEHPCNEEN 79
Query: 231 NRKYAFKAA--------HPNMRTYYFCTDTGKEMELWMKAM 263
K+ F+ N +Y T +ME W+K++
Sbjct: 80 PGKFLFEVVPGGDRDRMTANHESYLLMASTQNDMEDWVKSI 120
>gi|11141889 WW45 protein [Homo sapiens]
Length = 383
Score = 53.1 bits (126), Expect = 1e-06
Identities = 25/80 (31%), Positives = 37/80 (46%), Gaps = 11/80 (13%)
Query: 8 EWISLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPTGWEEAYT 67
E + LP W+ T GR ++I+ +T W HP+ E LP GWE +
Sbjct: 197 EDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREG-----------LPPGWERVES 245
Query: 68 FEGARYYINHNERKVTCKHP 87
E YY++H +K +HP
Sbjct: 246 SEFGTYYVDHTNKKAQYRHP 265
Score = 39.7 bits (91), Expect = 0.016
Identities = 15/41 (36%), Positives = 21/41 (51%)
Query: 48 VTGHRRQSTDLPTGWEEAYTFEGARYYINHNERKVTCKHPV 88
+T H + LP GW +T G +YYI+HN HP+
Sbjct: 191 LTNHGSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPL 231
>gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 52.8 bits (125), Expect = 2e-06
Identities = 31/90 (34%), Positives = 39/90 (43%), Gaps = 11/90 (12%)
Query: 12 LPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTD--------LPTGWE 63
LP W I GR FFI+ K+TTW P V H R T LP GWE
Sbjct: 378 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPV---HMRSKTSLNPNDLGPLPPGWE 434
Query: 64 EAYTFEGARYYINHNERKVTCKHPVTGQPS 93
E +G +YI+HN + + P P+
Sbjct: 435 ERIHLDGRTFYIDHNSKITQWEDPRLQNPA 464
Score = 40.8 bits (94), Expect = 0.007
Identities = 24/76 (31%), Positives = 30/76 (39%), Gaps = 13/76 (17%)
Query: 13 PRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPTGWEEAYTFEGAR 72
P S G R V E S ++H G LP+GWEE +G
Sbjct: 234 PPSAPAGRARSSTVTGGEEPTPSVAYVHTTPG-------------LPSGWEERKDAKGRT 280
Query: 73 YYINHNERKVTCKHPV 88
YY+NHN R T P+
Sbjct: 281 YYVNHNNRTTTWTRPI 296
Score = 35.4 bits (80), Expect = 0.30
Identities = 18/49 (36%), Positives = 23/49 (46%), Gaps = 2/49 (4%)
Query: 58 LPTGWEEAYTFEGARYYINHNERKVTCKHP--VTGQPSQDNCIFVVNEQ 104
LP GWEE G YY+NHN R P + DN I +N++
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQE 122
Score = 31.2 bits (69), Expect = 5.7
Identities = 27/101 (26%), Positives = 40/101 (39%), Gaps = 17/101 (16%)
Query: 12 LPRSWTYGITRGGRVFFINEEAKSTTWLHPV--------TGEAVVTGH--------RRQS 55
LP W GR +++N ++TTW P+ +G A + + R +S
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 325
Query: 56 TDLPTGWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDN 96
PT A EGA+ K T +P + QPS N
Sbjct: 326 LSSPTVTLSA-PLEGAKDSPVRRAVKDTLSNPQSPQPSPYN 365
Score = 30.8 bits (68), Expect = 7.5
Identities = 14/39 (35%), Positives = 18/39 (46%)
Query: 12 LPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTG 50
LP W I GR F+I+ +K T W P +TG
Sbjct: 429 LPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITG 467
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 52.8 bits (125), Expect = 2e-06
Identities = 31/90 (34%), Positives = 39/90 (43%), Gaps = 11/90 (12%)
Query: 12 LPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTD--------LPTGWE 63
LP W I GR FFI+ K+TTW P V H R T LP GWE
Sbjct: 479 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPV---HMRSKTSLNPNDLGPLPPGWE 535
Query: 64 EAYTFEGARYYINHNERKVTCKHPVTGQPS 93
E +G +YI+HN + + P P+
Sbjct: 536 ERIHLDGRTFYIDHNSKITQWEDPRLQNPA 565
Score = 39.7 bits (91), Expect = 0.016
Identities = 15/31 (48%), Positives = 19/31 (61%)
Query: 58 LPTGWEEAYTFEGARYYINHNERKVTCKHPV 88
LP+GWEE +G YY+NHN R T P+
Sbjct: 367 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPI 397
Score = 35.4 bits (80), Expect = 0.30
Identities = 18/49 (36%), Positives = 23/49 (46%), Gaps = 2/49 (4%)
Query: 58 LPTGWEEAYTFEGARYYINHNERKVTCKHP--VTGQPSQDNCIFVVNEQ 104
LP GWEE G YY+NHN R P + DN I +N++
Sbjct: 195 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQE 243
Score = 31.2 bits (69), Expect = 5.7
Identities = 27/101 (26%), Positives = 40/101 (39%), Gaps = 17/101 (16%)
Query: 12 LPRSWTYGITRGGRVFFINEEAKSTTWLHPV--------TGEAVVTGH--------RRQS 55
LP W GR +++N ++TTW P+ +G A + + R +S
Sbjct: 367 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 426
Query: 56 TDLPTGWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDN 96
PT A EGA+ K T +P + QPS N
Sbjct: 427 LSSPTVTLSA-PLEGAKDSPVRRAVKDTLSNPQSPQPSPYN 466
Score = 30.8 bits (68), Expect = 7.5
Identities = 14/39 (35%), Positives = 18/39 (46%)
Query: 12 LPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTG 50
LP W I GR F+I+ +K T W P +TG
Sbjct: 530 LPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITG 568
>gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 52.8 bits (125), Expect = 2e-06
Identities = 31/90 (34%), Positives = 39/90 (43%), Gaps = 11/90 (12%)
Query: 12 LPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTD--------LPTGWE 63
LP W I GR FFI+ K+TTW P V H R T LP GWE
Sbjct: 358 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPV---HMRSKTSLNPNDLGPLPPGWE 414
Query: 64 EAYTFEGARYYINHNERKVTCKHPVTGQPS 93
E +G +YI+HN + + P P+
Sbjct: 415 ERIHLDGRTFYIDHNSKITQWEDPRLQNPA 444
Score = 39.7 bits (91), Expect = 0.016
Identities = 15/31 (48%), Positives = 19/31 (61%)
Query: 58 LPTGWEEAYTFEGARYYINHNERKVTCKHPV 88
LP+GWEE +G YY+NHN R T P+
Sbjct: 246 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPI 276
Score = 35.4 bits (80), Expect = 0.30
Identities = 18/49 (36%), Positives = 23/49 (46%), Gaps = 2/49 (4%)
Query: 58 LPTGWEEAYTFEGARYYINHNERKVTCKHP--VTGQPSQDNCIFVVNEQ 104
LP GWEE G YY+NHN R P + DN I +N++
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQE 122
Score = 31.2 bits (69), Expect = 5.7
Identities = 27/101 (26%), Positives = 40/101 (39%), Gaps = 17/101 (16%)
Query: 12 LPRSWTYGITRGGRVFFINEEAKSTTWLHPV--------TGEAVVTGH--------RRQS 55
LP W GR +++N ++TTW P+ +G A + + R +S
Sbjct: 246 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 305
Query: 56 TDLPTGWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDN 96
PT A EGA+ K T +P + QPS N
Sbjct: 306 LSSPTVTLSA-PLEGAKDSPVRRAVKDTLSNPQSPQPSPYN 345
Score = 30.8 bits (68), Expect = 7.5
Identities = 14/39 (35%), Positives = 18/39 (46%)
Query: 12 LPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTG 50
LP W I GR F+I+ +K T W P +TG
Sbjct: 409 LPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITG 447
>gi|222352092 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 52.8 bits (125), Expect = 2e-06
Identities = 31/90 (34%), Positives = 39/90 (43%), Gaps = 11/90 (12%)
Query: 12 LPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTD--------LPTGWE 63
LP W I GR FFI+ K+TTW P V H R T LP GWE
Sbjct: 358 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPV---HMRSKTSLNPNDLGPLPPGWE 414
Query: 64 EAYTFEGARYYINHNERKVTCKHPVTGQPS 93
E +G +YI+HN + + P P+
Sbjct: 415 ERIHLDGRTFYIDHNSKITQWEDPRLQNPA 444
Score = 39.7 bits (91), Expect = 0.016
Identities = 15/31 (48%), Positives = 19/31 (61%)
Query: 58 LPTGWEEAYTFEGARYYINHNERKVTCKHPV 88
LP+GWEE +G YY+NHN R T P+
Sbjct: 246 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPI 276
Score = 35.4 bits (80), Expect = 0.30
Identities = 18/49 (36%), Positives = 23/49 (46%), Gaps = 2/49 (4%)
Query: 58 LPTGWEEAYTFEGARYYINHNERKVTCKHP--VTGQPSQDNCIFVVNEQ 104
LP GWEE G YY+NHN R P + DN I +N++
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQE 122
Score = 31.2 bits (69), Expect = 5.7
Identities = 27/101 (26%), Positives = 40/101 (39%), Gaps = 17/101 (16%)
Query: 12 LPRSWTYGITRGGRVFFINEEAKSTTWLHPV--------TGEAVVTGH--------RRQS 55
LP W GR +++N ++TTW P+ +G A + + R +S
Sbjct: 246 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 305
Query: 56 TDLPTGWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDN 96
PT A EGA+ K T +P + QPS N
Sbjct: 306 LSSPTVTLSA-PLEGAKDSPVRRAVKDTLSNPQSPQPSPYN 345
Score = 30.8 bits (68), Expect = 7.5
Identities = 14/39 (35%), Positives = 18/39 (46%)
Query: 12 LPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTG 50
LP W I GR F+I+ +K T W P +TG
Sbjct: 409 LPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITG 447
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 52.8 bits (125), Expect = 2e-06
Identities = 31/90 (34%), Positives = 39/90 (43%), Gaps = 11/90 (12%)
Query: 12 LPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTD--------LPTGWE 63
LP W I GR FFI+ K+TTW P V H R T LP GWE
Sbjct: 471 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPV---HMRSKTSLNPNDLGPLPPGWE 527
Query: 64 EAYTFEGARYYINHNERKVTCKHPVTGQPS 93
E +G +YI+HN + + P P+
Sbjct: 528 ERIHLDGRTFYIDHNSKITQWEDPRLQNPA 557
Score = 39.7 bits (91), Expect = 0.016
Identities = 15/31 (48%), Positives = 19/31 (61%)
Query: 58 LPTGWEEAYTFEGARYYINHNERKVTCKHPV 88
LP+GWEE +G YY+NHN R T P+
Sbjct: 359 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPI 389
Score = 35.4 bits (80), Expect = 0.30
Identities = 18/49 (36%), Positives = 23/49 (46%), Gaps = 2/49 (4%)
Query: 58 LPTGWEEAYTFEGARYYINHNERKVTCKHP--VTGQPSQDNCIFVVNEQ 104
LP GWEE G YY+NHN R P + DN I +N++
Sbjct: 187 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQE 235
Score = 31.2 bits (69), Expect = 5.7
Identities = 27/101 (26%), Positives = 40/101 (39%), Gaps = 17/101 (16%)
Query: 12 LPRSWTYGITRGGRVFFINEEAKSTTWLHPV--------TGEAVVTGH--------RRQS 55
LP W GR +++N ++TTW P+ +G A + + R +S
Sbjct: 359 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 418
Query: 56 TDLPTGWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDN 96
PT A EGA+ K T +P + QPS N
Sbjct: 419 LSSPTVTLSA-PLEGAKDSPVRRAVKDTLSNPQSPQPSPYN 458
Score = 30.8 bits (68), Expect = 7.5
Identities = 14/39 (35%), Positives = 18/39 (46%)
Query: 12 LPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTG 50
LP W I GR F+I+ +K T W P +TG
Sbjct: 522 LPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITG 560
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 52.8 bits (125), Expect = 2e-06
Identities = 31/90 (34%), Positives = 39/90 (43%), Gaps = 11/90 (12%)
Query: 12 LPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTD--------LPTGWE 63
LP W I GR FFI+ K+TTW P V H R T LP GWE
Sbjct: 491 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPV---HMRSKTSLNPNDLGPLPPGWE 547
Query: 64 EAYTFEGARYYINHNERKVTCKHPVTGQPS 93
E +G +YI+HN + + P P+
Sbjct: 548 ERIHLDGRTFYIDHNSKITQWEDPRLQNPA 577
Score = 40.8 bits (94), Expect = 0.007
Identities = 24/76 (31%), Positives = 30/76 (39%), Gaps = 13/76 (17%)
Query: 13 PRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPTGWEEAYTFEGAR 72
P S G R V E S ++H G LP+GWEE +G
Sbjct: 347 PPSAPAGRARSSTVTGGEEPTPSVAYVHTTPG-------------LPSGWEERKDAKGRT 393
Query: 73 YYINHNERKVTCKHPV 88
YY+NHN R T P+
Sbjct: 394 YYVNHNNRTTTWTRPI 409
Score = 35.4 bits (80), Expect = 0.30
Identities = 18/49 (36%), Positives = 23/49 (46%), Gaps = 2/49 (4%)
Query: 58 LPTGWEEAYTFEGARYYINHNERKVTCKHP--VTGQPSQDNCIFVVNEQ 104
LP GWEE G YY+NHN R P + DN I +N++
Sbjct: 187 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQE 235
Score = 31.2 bits (69), Expect = 5.7
Identities = 27/101 (26%), Positives = 40/101 (39%), Gaps = 17/101 (16%)
Query: 12 LPRSWTYGITRGGRVFFINEEAKSTTWLHPV--------TGEAVVTGH--------RRQS 55
LP W GR +++N ++TTW P+ +G A + + R +S
Sbjct: 379 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 438
Query: 56 TDLPTGWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDN 96
PT A EGA+ K T +P + QPS N
Sbjct: 439 LSSPTVTLSA-PLEGAKDSPVRRAVKDTLSNPQSPQPSPYN 478
Score = 30.8 bits (68), Expect = 7.5
Identities = 14/39 (35%), Positives = 18/39 (46%)
Query: 12 LPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTG 50
LP W I GR F+I+ +K T W P +TG
Sbjct: 542 LPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITG 580
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 52.8 bits (125), Expect = 2e-06
Identities = 31/90 (34%), Positives = 39/90 (43%), Gaps = 11/90 (12%)
Query: 12 LPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTD--------LPTGWE 63
LP W I GR FFI+ K+TTW P V H R T LP GWE
Sbjct: 499 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPV---HMRSKTSLNPNDLGPLPPGWE 555
Query: 64 EAYTFEGARYYINHNERKVTCKHPVTGQPS 93
E +G +YI+HN + + P P+
Sbjct: 556 ERIHLDGRTFYIDHNSKITQWEDPRLQNPA 585
Score = 40.8 bits (94), Expect = 0.007
Identities = 24/76 (31%), Positives = 30/76 (39%), Gaps = 13/76 (17%)
Query: 13 PRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPTGWEEAYTFEGAR 72
P S G R V E S ++H G LP+GWEE +G
Sbjct: 355 PPSAPAGRARSSTVTGGEEPTPSVAYVHTTPG-------------LPSGWEERKDAKGRT 401
Query: 73 YYINHNERKVTCKHPV 88
YY+NHN R T P+
Sbjct: 402 YYVNHNNRTTTWTRPI 417
Score = 35.4 bits (80), Expect = 0.30
Identities = 18/49 (36%), Positives = 23/49 (46%), Gaps = 2/49 (4%)
Query: 58 LPTGWEEAYTFEGARYYINHNERKVTCKHP--VTGQPSQDNCIFVVNEQ 104
LP GWEE G YY+NHN R P + DN I +N++
Sbjct: 195 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQE 243
Score = 31.2 bits (69), Expect = 5.7
Identities = 27/101 (26%), Positives = 40/101 (39%), Gaps = 17/101 (16%)
Query: 12 LPRSWTYGITRGGRVFFINEEAKSTTWLHPV--------TGEAVVTGH--------RRQS 55
LP W GR +++N ++TTW P+ +G A + + R +S
Sbjct: 387 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 446
Query: 56 TDLPTGWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDN 96
PT A EGA+ K T +P + QPS N
Sbjct: 447 LSSPTVTLSA-PLEGAKDSPVRRAVKDTLSNPQSPQPSPYN 486
Score = 30.8 bits (68), Expect = 7.5
Identities = 14/39 (35%), Positives = 18/39 (46%)
Query: 12 LPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTG 50
LP W I GR F+I+ +K T W P +TG
Sbjct: 550 LPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITG 588
>gi|222352084 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 52.8 bits (125), Expect = 2e-06
Identities = 31/90 (34%), Positives = 39/90 (43%), Gaps = 11/90 (12%)
Query: 12 LPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTD--------LPTGWE 63
LP W I GR FFI+ K+TTW P V H R T LP GWE
Sbjct: 378 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPV---HMRSKTSLNPNDLGPLPPGWE 434
Query: 64 EAYTFEGARYYINHNERKVTCKHPVTGQPS 93
E +G +YI+HN + + P P+
Sbjct: 435 ERIHLDGRTFYIDHNSKITQWEDPRLQNPA 464
Score = 40.8 bits (94), Expect = 0.007
Identities = 24/76 (31%), Positives = 30/76 (39%), Gaps = 13/76 (17%)
Query: 13 PRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPTGWEEAYTFEGAR 72
P S G R V E S ++H G LP+GWEE +G
Sbjct: 234 PPSAPAGRARSSTVTGGEEPTPSVAYVHTTPG-------------LPSGWEERKDAKGRT 280
Query: 73 YYINHNERKVTCKHPV 88
YY+NHN R T P+
Sbjct: 281 YYVNHNNRTTTWTRPI 296
Score = 35.4 bits (80), Expect = 0.30
Identities = 18/49 (36%), Positives = 23/49 (46%), Gaps = 2/49 (4%)
Query: 58 LPTGWEEAYTFEGARYYINHNERKVTCKHP--VTGQPSQDNCIFVVNEQ 104
LP GWEE G YY+NHN R P + DN I +N++
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQE 122
Score = 31.2 bits (69), Expect = 5.7
Identities = 27/101 (26%), Positives = 40/101 (39%), Gaps = 17/101 (16%)
Query: 12 LPRSWTYGITRGGRVFFINEEAKSTTWLHPV--------TGEAVVTGH--------RRQS 55
LP W GR +++N ++TTW P+ +G A + + R +S
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 325
Query: 56 TDLPTGWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDN 96
PT A EGA+ K T +P + QPS N
Sbjct: 326 LSSPTVTLSA-PLEGAKDSPVRRAVKDTLSNPQSPQPSPYN 365
Score = 30.8 bits (68), Expect = 7.5
Identities = 14/39 (35%), Positives = 18/39 (46%)
Query: 12 LPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTG 50
LP W I GR F+I+ +K T W P +TG
Sbjct: 429 LPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITG 467
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.127 0.364
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,916,010
Number of Sequences: 37866
Number of extensions: 2169803
Number of successful extensions: 8966
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 110
Number of HSP's successfully gapped in prelim test: 483
Number of HSP's that attempted gapping in prelim test: 7727
Number of HSP's gapped (non-prelim): 1627
length of query: 1116
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1003
effective length of database: 13,968,660
effective search space: 14010565980
effective search space used: 14010565980
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.