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Search of human proteins with 190886457
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens]
(553 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens] 1115 0.0
gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens] 1041 0.0
gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens] 830 0.0
gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens] 830 0.0
gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens] 830 0.0
gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens] 820 0.0
gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens] 818 0.0
gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens] 812 0.0
gi|32483399 p21-activated kinase 2 [Homo sapiens] 763 0.0
gi|62422561 p21-activated kinase 4 isoform 2 [Homo sapiens] 335 6e-92
gi|62422563 p21-activated kinase 4 isoform 2 [Homo sapiens] 335 6e-92
gi|62422554 p21-activated kinase 4 isoform 1 [Homo sapiens] 300 3e-81
gi|62422557 p21-activated kinase 4 isoform 1 [Homo sapiens] 300 3e-81
gi|5031975 p21-activated kinase 4 isoform 1 [Homo sapiens] 300 3e-81
gi|29826329 p21-activated kinase 7 [Homo sapiens] 299 4e-81
gi|24308191 p21-activated kinase 7 [Homo sapiens] 299 4e-81
gi|191252782 p21-activated kinase 6 [Homo sapiens] 290 3e-78
gi|191252780 p21-activated kinase 6 [Homo sapiens] 290 3e-78
gi|9910476 p21-activated kinase 6 [Homo sapiens] 290 3e-78
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 228 1e-59
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 227 2e-59
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 224 1e-58
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 224 1e-58
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 224 1e-58
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 223 4e-58
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 204 2e-52
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 202 8e-52
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 200 3e-51
gi|145275208 myosin IIIA [Homo sapiens] 199 4e-51
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 199 7e-51
>gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens]
Length = 553
Score = 1115 bits (2885), Expect = 0.0
Identities = 553/553 (100%), Positives = 553/553 (100%)
Query: 1 MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILP 60
MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILP
Sbjct: 1 MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILP 60
Query: 61 GDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKN 120
GDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKN
Sbjct: 61 GDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKN 120
Query: 121 PQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDD 180
PQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDD
Sbjct: 121 PQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDD 180
Query: 181 DDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTE 240
DDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTE
Sbjct: 181 DDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTE 240
Query: 241 KQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQ 300
KQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQ
Sbjct: 241 KQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQ 300
Query: 301 MNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC 360
MNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC
Sbjct: 301 MNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC 360
Query: 361 MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSK 420
MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSK
Sbjct: 361 MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSK 420
Query: 421 RSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNG 480
RSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNG
Sbjct: 421 RSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNG 480
Query: 481 TPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQVRKLRFQVFSNFSMIAASIPEDC 540
TPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQVRKLRFQVFSNFSMIAASIPEDC
Sbjct: 481 TPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQVRKLRFQVFSNFSMIAASIPEDC 540
Query: 541 QAPLQPHSTDCCS 553
QAPLQPHSTDCCS
Sbjct: 541 QAPLQPHSTDCCS 553
>gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens]
Length = 545
Score = 1041 bits (2693), Expect = 0.0
Identities = 518/522 (99%), Positives = 520/522 (99%)
Query: 1 MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILP 60
MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILP
Sbjct: 1 MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILP 60
Query: 61 GDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKN 120
GDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKN
Sbjct: 61 GDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKN 120
Query: 121 PQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDD 180
PQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDD
Sbjct: 121 PQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDD 180
Query: 181 DDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTE 240
DDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTE
Sbjct: 181 DDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTE 240
Query: 241 KQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQ 300
KQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQ
Sbjct: 241 KQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQ 300
Query: 301 MNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC 360
MNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC
Sbjct: 301 MNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC 360
Query: 361 MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSK 420
MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSK
Sbjct: 361 MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSK 420
Query: 421 RSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNG 480
RSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNG
Sbjct: 421 RSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNG 480
Query: 481 TPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQVRKLR 522
TPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQ + L+
Sbjct: 481 TPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLK 522
>gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 830 bits (2144), Expect = 0.0
Identities = 423/525 (80%), Positives = 465/525 (88%), Gaps = 21/525 (4%)
Query: 3 NNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPG- 61
++GLD ++KPPAPP+R S ++D+ LNH SKPLP PEEK KK R RSI PG
Sbjct: 2 SDGLDNEEKPPAPPLRMNSN-----NRDSSALNHSSKPLPMAPEEKNKKARL-RSIFPGG 55
Query: 62 -DKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKN 120
DKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTG+PEQWARLLQTSNITK EQKKN
Sbjct: 56 GDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTSNITKLEQKKN 115
Query: 121 PQAVLDVLEFYNSKKTSNSQKYMSFT--DKSAEDYNSSNALNVKAVSETPAVPPVSEDED 178
PQAVLDVL+FY+SK+T N+QKYMSFT DKSA Y +++ + K SE P PPVSE+ED
Sbjct: 116 PQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTASEPPLAPPVSEEED 175
Query: 179 DDD----DDATPPPVIAPRPEHTKSVYTRSVIEPL--PVTPTRDVATSPISPTENNTTPP 232
+++ D+ PPPVIAPRPEHTKS+YTRSV+E + P P ++V T P + N++T
Sbjct: 176 EEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEV-TPPSAENANSST-- 232
Query: 233 DALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVAT 292
L RNT++Q+KK KM+DEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTA+D+AT
Sbjct: 233 --LYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIAT 290
Query: 293 GQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSL 352
GQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSL
Sbjct: 291 GQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSL 350
Query: 353 TDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCA 412
TDVVTETCMDEGQIAAVCRECLQAL+FLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCA
Sbjct: 351 TDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCA 410
Query: 413 QITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRA 472
QITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEM+EGEPPYLNENPLRA
Sbjct: 411 QITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRA 470
Query: 473 LYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQ 517
LYLIATNGTPELQNPE+LSA+FRDFLNRCLEMDV++RGSAKELLQ
Sbjct: 471 LYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQ 515
>gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 830 bits (2144), Expect = 0.0
Identities = 423/525 (80%), Positives = 465/525 (88%), Gaps = 21/525 (4%)
Query: 3 NNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPG- 61
++GLD ++KPPAPP+R S ++D+ LNH SKPLP PEEK KK R RSI PG
Sbjct: 2 SDGLDNEEKPPAPPLRMNSN-----NRDSSALNHSSKPLPMAPEEKNKKARL-RSIFPGG 55
Query: 62 -DKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKN 120
DKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTG+PEQWARLLQTSNITK EQKKN
Sbjct: 56 GDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTSNITKLEQKKN 115
Query: 121 PQAVLDVLEFYNSKKTSNSQKYMSFT--DKSAEDYNSSNALNVKAVSETPAVPPVSEDED 178
PQAVLDVL+FY+SK+T N+QKYMSFT DKSA Y +++ + K SE P PPVSE+ED
Sbjct: 116 PQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTASEPPLAPPVSEEED 175
Query: 179 DDD----DDATPPPVIAPRPEHTKSVYTRSVIEPL--PVTPTRDVATSPISPTENNTTPP 232
+++ D+ PPPVIAPRPEHTKS+YTRSV+E + P P ++V T P + N++T
Sbjct: 176 EEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEV-TPPSAENANSST-- 232
Query: 233 DALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVAT 292
L RNT++Q+KK KM+DEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTA+D+AT
Sbjct: 233 --LYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIAT 290
Query: 293 GQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSL 352
GQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSL
Sbjct: 291 GQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSL 350
Query: 353 TDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCA 412
TDVVTETCMDEGQIAAVCRECLQAL+FLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCA
Sbjct: 351 TDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCA 410
Query: 413 QITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRA 472
QITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEM+EGEPPYLNENPLRA
Sbjct: 411 QITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRA 470
Query: 473 LYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQ 517
LYLIATNGTPELQNPE+LSA+FRDFLNRCLEMDV++RGSAKELLQ
Sbjct: 471 LYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQ 515
>gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 830 bits (2144), Expect = 0.0
Identities = 423/525 (80%), Positives = 465/525 (88%), Gaps = 21/525 (4%)
Query: 3 NNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPG- 61
++GLD ++KPPAPP+R S ++D+ LNH SKPLP PEEK KK R RSI PG
Sbjct: 2 SDGLDNEEKPPAPPLRMNSN-----NRDSSALNHSSKPLPMAPEEKNKKARL-RSIFPGG 55
Query: 62 -DKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKN 120
DKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTG+PEQWARLLQTSNITK EQKKN
Sbjct: 56 GDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTSNITKLEQKKN 115
Query: 121 PQAVLDVLEFYNSKKTSNSQKYMSFT--DKSAEDYNSSNALNVKAVSETPAVPPVSEDED 178
PQAVLDVL+FY+SK+T N+QKYMSFT DKSA Y +++ + K SE P PPVSE+ED
Sbjct: 116 PQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTASEPPLAPPVSEEED 175
Query: 179 DDD----DDATPPPVIAPRPEHTKSVYTRSVIEPL--PVTPTRDVATSPISPTENNTTPP 232
+++ D+ PPPVIAPRPEHTKS+YTRSV+E + P P ++V T P + N++T
Sbjct: 176 EEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEV-TPPSAENANSST-- 232
Query: 233 DALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVAT 292
L RNT++Q+KK KM+DEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTA+D+AT
Sbjct: 233 --LYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIAT 290
Query: 293 GQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSL 352
GQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSL
Sbjct: 291 GQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSL 350
Query: 353 TDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCA 412
TDVVTETCMDEGQIAAVCRECLQAL+FLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCA
Sbjct: 351 TDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCA 410
Query: 413 QITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRA 472
QITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEM+EGEPPYLNENPLRA
Sbjct: 411 QITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRA 470
Query: 473 LYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQ 517
LYLIATNGTPELQNPE+LSA+FRDFLNRCLEMDV++RGSAKELLQ
Sbjct: 471 LYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQ 515
>gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens]
Length = 559
Score = 820 bits (2118), Expect = 0.0
Identities = 423/540 (78%), Positives = 465/540 (86%), Gaps = 36/540 (6%)
Query: 3 NNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPG- 61
++GLD ++KPPAPP+R S ++D+ LNH SKPLP PEEK KK R RSI PG
Sbjct: 2 SDGLDNEEKPPAPPLRMNSN-----NRDSSALNHSSKPLPMAPEEKNKKARL-RSIFPGG 55
Query: 62 -DKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFT---------------GMPEQWAR 105
DKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFT G+PEQWAR
Sbjct: 56 GDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWAR 115
Query: 106 LLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFT--DKSAEDYNSSNALNVKA 163
LLQTSNITK EQKKNPQAVLDVL+FY+SK+T N+QKYMSFT DKSA Y +++ + K
Sbjct: 116 LLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKT 175
Query: 164 VSETPAVPPVSEDEDDDD----DDATPPPVIAPRPEHTKSVYTRSVIEPL--PVTPTRDV 217
SE P PPVSE+ED+++ D+ PPPVIAPRPEHTKS+YTRSV+E + P P ++V
Sbjct: 176 ASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEV 235
Query: 218 ATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIG 277
T P + N++T L RNT++Q+KK KM+DEEILEKLRSIVSVGDPKKKYTRFEKIG
Sbjct: 236 -TPPSAENANSST----LYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIG 290
Query: 278 QGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG 337
QGASGTVYTA+D+ATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG
Sbjct: 291 QGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG 350
Query: 338 DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILL 397
DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQAL+FLHSNQVIHRDIKSDNILL
Sbjct: 351 DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILL 410
Query: 398 GMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEM 457
GMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEM
Sbjct: 411 GMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEM 470
Query: 458 IEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQ 517
+EGEPPYLNENPLRALYLIATNGTPELQNPE+LSA+FRDFLNRCLEMDV++RGSAKELLQ
Sbjct: 471 VEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
>gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens]
Length = 565
Score = 818 bits (2112), Expect = 0.0
Identities = 423/546 (77%), Positives = 465/546 (85%), Gaps = 42/546 (7%)
Query: 3 NNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPG- 61
++GLD ++KPPAPP+R S ++D+ LNH SKPLP PEEK KK R RSI PG
Sbjct: 2 SDGLDNEEKPPAPPLRMNSN-----NRDSSALNHSSKPLPMAPEEKNKKARL-RSIFPGG 55
Query: 62 -DKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFT---------------------GM 99
DKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFT G+
Sbjct: 56 GDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKMGI 115
Query: 100 PEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFT--DKSAEDYNSSN 157
PEQWARLLQTSNITK EQKKNPQAVLDVL+FY+SK+T N+QKYMSFT DKSA Y +++
Sbjct: 116 PEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAH 175
Query: 158 ALNVKAVSETPAVPPVSEDEDDDD----DDATPPPVIAPRPEHTKSVYTRSVIEPL--PV 211
+ K SE P PPVSE+ED+++ D+ PPPVIAPRPEHTKS+YTRSV+E + P
Sbjct: 176 PSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPA 235
Query: 212 TPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYT 271
P ++V T P + N++T L RNT++Q+KK KM+DEEILEKLRSIVSVGDPKKKYT
Sbjct: 236 VPNKEV-TPPSAENANSST----LYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYT 290
Query: 272 RFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYL 331
RFEKIGQGASGTVYTA+D+ATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYL
Sbjct: 291 RFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYL 350
Query: 332 DSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIK 391
DSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQAL+FLHSNQVIHRDIK
Sbjct: 351 DSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIK 410
Query: 392 SDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLG 451
SDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLG
Sbjct: 411 SDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLG 470
Query: 452 IMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGS 511
IMAIEM+EGEPPYLNENPLRALYLIATNGTPELQNPE+LSA+FRDFLNRCLEMDV++RGS
Sbjct: 471 IMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGS 530
Query: 512 AKELLQ 517
AKELLQ
Sbjct: 531 AKELLQ 536
>gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens]
Length = 580
Score = 812 bits (2097), Expect = 0.0
Identities = 423/561 (75%), Positives = 465/561 (82%), Gaps = 57/561 (10%)
Query: 3 NNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPG- 61
++GLD ++KPPAPP+R S ++D+ LNH SKPLP PEEK KK R RSI PG
Sbjct: 2 SDGLDNEEKPPAPPLRMNSN-----NRDSSALNHSSKPLPMAPEEKNKKARL-RSIFPGG 55
Query: 62 -DKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFT----------------------- 97
DKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFT
Sbjct: 56 GDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKMPD 115
Query: 98 -------------GMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMS 144
G+PEQWARLLQTSNITK EQKKNPQAVLDVL+FY+SK+T N+QKYMS
Sbjct: 116 LYGSQMCPGKLPEGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMS 175
Query: 145 FT--DKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDDD----DDATPPPVIAPRPEHTK 198
FT DKSA Y +++ + K SE P PPVSE+ED+++ D+ PPPVIAPRPEHTK
Sbjct: 176 FTSGDKSAHGYIAAHPSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTK 235
Query: 199 SVYTRSVIEPL--PVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEK 256
S+YTRSV+E + P P ++V T P + N++T L RNT++Q+KK KM+DEEILEK
Sbjct: 236 SIYTRSVVESIASPAVPNKEV-TPPSAENANSST----LYRNTDRQRKKSKMTDEEILEK 290
Query: 257 LRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEI 316
LRSIVSVGDPKKKYTRFEKIGQGASGTVYTA+D+ATGQEVAIKQMNLQQQPKKELIINEI
Sbjct: 291 LRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEI 350
Query: 317 LVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQA 376
LVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQA
Sbjct: 351 LVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQA 410
Query: 377 LEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV 436
L+FLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV
Sbjct: 411 LDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV 470
Query: 437 TRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRD 496
TRKAYGPKVDIWSLGIMAIEM+EGEPPYLNENPLRALYLIATNGTPELQNPE+LSA+FRD
Sbjct: 471 TRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRD 530
Query: 497 FLNRCLEMDVEKRGSAKELLQ 517
FLNRCLEMDV++RGSAKELLQ
Sbjct: 531 FLNRCLEMDVDRRGSAKELLQ 551
>gi|32483399 p21-activated kinase 2 [Homo sapiens]
Length = 524
Score = 763 bits (1969), Expect = 0.0
Identities = 393/518 (75%), Positives = 440/518 (84%), Gaps = 23/518 (4%)
Query: 1 MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILP 60
MS+NG +++DKPPAPP+R +ST+ G KD + NH KPLP PEEKK + +
Sbjct: 1 MSDNG-ELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRHKIISIFSG 59
Query: 61 GDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKN 120
+K +KKKEKERPEIS PSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITK EQKKN
Sbjct: 60 TEKGSKKKEKERPEISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKN 119
Query: 121 PQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSN-ALNVKAVSETPAVPPVSEDEDD 179
PQAVLDVL+FY+S QKY+SFT + + S ALN K +E PAV V+E+EDD
Sbjct: 120 PQAVLDVLKFYDSNTVK--QKYLSFTPPEKDGFPSGTPALNAKG-TEAPAV--VTEEEDD 174
Query: 180 DDDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNT 239
D++ T PPVIAPRP+HTKS+YTRSVI+P+P +P+ + D ++
Sbjct: 175 DEE--TAPPVIAPRPDHTKSIYTRSVIDPVP---------APVGDSH-----VDGAAKSL 218
Query: 240 EKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIK 299
+KQKKK KM+DEEI+EKLR+IVS+GDPKKKYTR+EKIGQGASGTV+TA DVA GQEVAIK
Sbjct: 219 DKQKKKTKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVAIK 278
Query: 300 QMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTET 359
Q+NLQ+QPKKELIINEILVM+E KNPNIVN+LDSYLVGDEL+VVMEYLAGGSLTDVVTET
Sbjct: 279 QINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTET 338
Query: 360 CMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQS 419
CMDE QIAAVCRECLQALEFLH+NQVIHRDIKSDN+LLGM+GSVKLTDFGFCAQITPEQS
Sbjct: 339 CMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQS 398
Query: 420 KRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATN 479
KRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEM+EGEPPYLNENPLRALYLIATN
Sbjct: 399 KRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATN 458
Query: 480 GTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQ 517
GTPELQNPEKLS IFRDFLNRCLEMDVEKRGSAKELLQ
Sbjct: 459 GTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQ 496
>gi|62422561 p21-activated kinase 4 isoform 2 [Homo sapiens]
Length = 438
Score = 335 bits (859), Expect = 6e-92
Identities = 186/450 (41%), Positives = 267/450 (59%), Gaps = 38/450 (8%)
Query: 68 KEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDV 127
K K+R EIS PS+FEH +H GFD +FTG+P QW L++ E + P+ ++D
Sbjct: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIE-------ESARRPKPLVDP 56
Query: 128 LEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDDDDDATPP 187
+ + + + A + S+ L + S + + PP A P
Sbjct: 57 ACITSIQPGAPKGE----PHDVAPNGPSAGGLAIPQSSSSSSRPPTRAR------GAPSP 106
Query: 188 PVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPK 247
V+ P + + P TP P P Q++ +
Sbjct: 107 GVLGPHASEPQ-------LAPPACTPAAPAVPGPPGPRS--------------PQREPQR 145
Query: 248 MSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQP 307
+S E+ L+ +V GDP+ F KIG+G++G V A ++G+ VA+K+M+L++Q
Sbjct: 146 VSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQ 205
Query: 308 KKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIA 367
++EL+ NE+++MR+ ++ N+V +SYLVGDELWVVME+L GG+LTD+VT T M+E QIA
Sbjct: 206 RRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIA 265
Query: 368 AVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGT 427
AVC LQAL LH+ VIHRDIKSD+ILL DG VKL+DFGFCAQ++ E +R ++VGT
Sbjct: 266 AVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGT 325
Query: 428 PYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNP 487
PYWMAPE+++R YGP+VDIWSLGIM IEM++GEPPY NE PL+A+ +I N P L+N
Sbjct: 326 PYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNL 385
Query: 488 EKLSAIFRDFLNRCLEMDVEKRGSAKELLQ 517
K+S + FL+R L D +R +A ELL+
Sbjct: 386 HKVSPSLKGFLDRLLVRDPAQRATAAELLK 415
>gi|62422563 p21-activated kinase 4 isoform 2 [Homo sapiens]
Length = 438
Score = 335 bits (859), Expect = 6e-92
Identities = 186/450 (41%), Positives = 267/450 (59%), Gaps = 38/450 (8%)
Query: 68 KEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDV 127
K K+R EIS PS+FEH +H GFD +FTG+P QW L++ E + P+ ++D
Sbjct: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIE-------ESARRPKPLVDP 56
Query: 128 LEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDDDDDATPP 187
+ + + + A + S+ L + S + + PP A P
Sbjct: 57 ACITSIQPGAPKGE----PHDVAPNGPSAGGLAIPQSSSSSSRPPTRAR------GAPSP 106
Query: 188 PVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPK 247
V+ P + + P TP P P Q++ +
Sbjct: 107 GVLGPHASEPQ-------LAPPACTPAAPAVPGPPGPRS--------------PQREPQR 145
Query: 248 MSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQP 307
+S E+ L+ +V GDP+ F KIG+G++G V A ++G+ VA+K+M+L++Q
Sbjct: 146 VSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQ 205
Query: 308 KKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIA 367
++EL+ NE+++MR+ ++ N+V +SYLVGDELWVVME+L GG+LTD+VT T M+E QIA
Sbjct: 206 RRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIA 265
Query: 368 AVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGT 427
AVC LQAL LH+ VIHRDIKSD+ILL DG VKL+DFGFCAQ++ E +R ++VGT
Sbjct: 266 AVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGT 325
Query: 428 PYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNP 487
PYWMAPE+++R YGP+VDIWSLGIM IEM++GEPPY NE PL+A+ +I N P L+N
Sbjct: 326 PYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNL 385
Query: 488 EKLSAIFRDFLNRCLEMDVEKRGSAKELLQ 517
K+S + FL+R L D +R +A ELL+
Sbjct: 386 HKVSPSLKGFLDRLLVRDPAQRATAAELLK 415
>gi|62422554 p21-activated kinase 4 isoform 1 [Homo sapiens]
Length = 591
Score = 300 bits (767), Expect = 3e-81
Identities = 146/276 (52%), Positives = 204/276 (73%)
Query: 242 QKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQM 301
Q++ ++S E+ L+ +V GDP+ F KIG+G++G V A ++G+ VA+K+M
Sbjct: 293 QREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKM 352
Query: 302 NLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCM 361
+L++Q ++EL+ NE+++MR+ ++ N+V +SYLVGDELWVVME+L GG+LTD+VT T M
Sbjct: 353 DLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRM 412
Query: 362 DEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR 421
+E QIAAVC LQAL LH+ VIHRDIKSD+ILL DG VKL+DFGFCAQ++ E +R
Sbjct: 413 NEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRR 472
Query: 422 STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGT 481
++VGTPYWMAPE+++R YGP+VDIWSLGIM IEM++GEPPY NE PL+A+ +I N
Sbjct: 473 KSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLP 532
Query: 482 PELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQ 517
P L+N K+S + FL+R L D +R +A ELL+
Sbjct: 533 PRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLK 568
Score = 54.7 bits (130), Expect = 2e-07
Identities = 23/43 (53%), Positives = 30/43 (69%)
Query: 68 KEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTS 110
K K+R EIS PS+FEH +H GFD +FTG+P QW L++ S
Sbjct: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEES 46
>gi|62422557 p21-activated kinase 4 isoform 1 [Homo sapiens]
Length = 591
Score = 300 bits (767), Expect = 3e-81
Identities = 146/276 (52%), Positives = 204/276 (73%)
Query: 242 QKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQM 301
Q++ ++S E+ L+ +V GDP+ F KIG+G++G V A ++G+ VA+K+M
Sbjct: 293 QREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKM 352
Query: 302 NLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCM 361
+L++Q ++EL+ NE+++MR+ ++ N+V +SYLVGDELWVVME+L GG+LTD+VT T M
Sbjct: 353 DLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRM 412
Query: 362 DEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR 421
+E QIAAVC LQAL LH+ VIHRDIKSD+ILL DG VKL+DFGFCAQ++ E +R
Sbjct: 413 NEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRR 472
Query: 422 STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGT 481
++VGTPYWMAPE+++R YGP+VDIWSLGIM IEM++GEPPY NE PL+A+ +I N
Sbjct: 473 KSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLP 532
Query: 482 PELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQ 517
P L+N K+S + FL+R L D +R +A ELL+
Sbjct: 533 PRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLK 568
Score = 54.7 bits (130), Expect = 2e-07
Identities = 23/43 (53%), Positives = 30/43 (69%)
Query: 68 KEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTS 110
K K+R EIS PS+FEH +H GFD +FTG+P QW L++ S
Sbjct: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEES 46
>gi|5031975 p21-activated kinase 4 isoform 1 [Homo sapiens]
Length = 591
Score = 300 bits (767), Expect = 3e-81
Identities = 146/276 (52%), Positives = 204/276 (73%)
Query: 242 QKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQM 301
Q++ ++S E+ L+ +V GDP+ F KIG+G++G V A ++G+ VA+K+M
Sbjct: 293 QREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKM 352
Query: 302 NLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCM 361
+L++Q ++EL+ NE+++MR+ ++ N+V +SYLVGDELWVVME+L GG+LTD+VT T M
Sbjct: 353 DLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRM 412
Query: 362 DEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR 421
+E QIAAVC LQAL LH+ VIHRDIKSD+ILL DG VKL+DFGFCAQ++ E +R
Sbjct: 413 NEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRR 472
Query: 422 STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGT 481
++VGTPYWMAPE+++R YGP+VDIWSLGIM IEM++GEPPY NE PL+A+ +I N
Sbjct: 473 KSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLP 532
Query: 482 PELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQ 517
P L+N K+S + FL+R L D +R +A ELL+
Sbjct: 533 PRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLK 568
Score = 54.7 bits (130), Expect = 2e-07
Identities = 23/43 (53%), Positives = 30/43 (69%)
Query: 68 KEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTS 110
K K+R EIS PS+FEH +H GFD +FTG+P QW L++ S
Sbjct: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEES 46
>gi|29826329 p21-activated kinase 7 [Homo sapiens]
Length = 719
Score = 299 bits (766), Expect = 4e-81
Identities = 146/290 (50%), Positives = 213/290 (73%), Gaps = 2/290 (0%)
Query: 227 NNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYT 286
++T PP + ++++Q + +S E+ L+ +VS GDP++ F KIG+G++G V
Sbjct: 408 SSTYPPPSWGSSSDQQPSR--VSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCI 465
Query: 287 AMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 346
A + TG++VA+K+M+L++Q ++EL+ NE+++MR+ + N+V+ SYLVGDELWVVME+
Sbjct: 466 ATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEF 525
Query: 347 LAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLT 406
L GG+LTD+VT T M+E QIA VC L+AL +LH+ VIHRDIKSD+ILL DG +KL+
Sbjct: 526 LEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLS 585
Query: 407 DFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLN 466
DFGFCAQ++ E KR ++VGTPYWMAPEV++R YG +VDIWSLGIM IEMI+GEPPY N
Sbjct: 586 DFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFN 645
Query: 467 ENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELL 516
E PL+A+ I + P +++ K+S++ R FL+ L + +R +A+ELL
Sbjct: 646 EPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELL 695
Score = 52.4 bits (124), Expect = 1e-06
Identities = 25/48 (52%), Positives = 34/48 (70%), Gaps = 1/48 (2%)
Query: 68 KEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLL-QTSNITK 114
K+K++ EIS PS+FEH +H GFD +FTG+P+QW LL T+N K
Sbjct: 4 KKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPK 51
>gi|24308191 p21-activated kinase 7 [Homo sapiens]
Length = 719
Score = 299 bits (766), Expect = 4e-81
Identities = 146/290 (50%), Positives = 213/290 (73%), Gaps = 2/290 (0%)
Query: 227 NNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYT 286
++T PP + ++++Q + +S E+ L+ +VS GDP++ F KIG+G++G V
Sbjct: 408 SSTYPPPSWGSSSDQQPSR--VSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCI 465
Query: 287 AMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 346
A + TG++VA+K+M+L++Q ++EL+ NE+++MR+ + N+V+ SYLVGDELWVVME+
Sbjct: 466 ATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEF 525
Query: 347 LAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLT 406
L GG+LTD+VT T M+E QIA VC L+AL +LH+ VIHRDIKSD+ILL DG +KL+
Sbjct: 526 LEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLS 585
Query: 407 DFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLN 466
DFGFCAQ++ E KR ++VGTPYWMAPEV++R YG +VDIWSLGIM IEMI+GEPPY N
Sbjct: 586 DFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFN 645
Query: 467 ENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELL 516
E PL+A+ I + P +++ K+S++ R FL+ L + +R +A+ELL
Sbjct: 646 EPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELL 695
Score = 52.4 bits (124), Expect = 1e-06
Identities = 25/48 (52%), Positives = 34/48 (70%), Gaps = 1/48 (2%)
Query: 68 KEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLL-QTSNITK 114
K+K++ EIS PS+FEH +H GFD +FTG+P+QW LL T+N K
Sbjct: 4 KKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPK 51
>gi|191252782 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 290 bits (741), Expect = 3e-78
Identities = 135/269 (50%), Positives = 201/269 (74%)
Query: 248 MSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQP 307
++ E+ LR +V GDP+ + KIG+G++G V A + +G++VA+K M+L++Q
Sbjct: 385 VTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQ 444
Query: 308 KKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIA 367
++EL+ NE+++MR+ ++ N+V SYLVG+ELWV+ME+L GG+LTD+V++ ++E QIA
Sbjct: 445 RRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIA 504
Query: 368 AVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGT 427
VC LQAL +LH+ VIHRDIKSD+ILL +DG VKL+DFGFCAQI+ + KR ++VGT
Sbjct: 505 TVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGT 564
Query: 428 PYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNP 487
PYWMAPEV++R Y +VDIWSLGIM IEM++GEPPY +++P++A+ + + P+L+N
Sbjct: 565 PYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNS 624
Query: 488 EKLSAIFRDFLNRCLEMDVEKRGSAKELL 516
K+S + RDFL R L D ++R +A+ELL
Sbjct: 625 HKVSPVLRDFLERMLVRDPQERATAQELL 653
Score = 57.8 bits (138), Expect = 3e-08
Identities = 22/44 (50%), Positives = 31/44 (70%)
Query: 66 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQT 109
+KK+K+RPEIS P +F+H +H FD G+F G+P QW +L T
Sbjct: 3 RKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDT 46
>gi|191252780 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 290 bits (741), Expect = 3e-78
Identities = 135/269 (50%), Positives = 201/269 (74%)
Query: 248 MSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQP 307
++ E+ LR +V GDP+ + KIG+G++G V A + +G++VA+K M+L++Q
Sbjct: 385 VTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQ 444
Query: 308 KKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIA 367
++EL+ NE+++MR+ ++ N+V SYLVG+ELWV+ME+L GG+LTD+V++ ++E QIA
Sbjct: 445 RRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIA 504
Query: 368 AVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGT 427
VC LQAL +LH+ VIHRDIKSD+ILL +DG VKL+DFGFCAQI+ + KR ++VGT
Sbjct: 505 TVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGT 564
Query: 428 PYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNP 487
PYWMAPEV++R Y +VDIWSLGIM IEM++GEPPY +++P++A+ + + P+L+N
Sbjct: 565 PYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNS 624
Query: 488 EKLSAIFRDFLNRCLEMDVEKRGSAKELL 516
K+S + RDFL R L D ++R +A+ELL
Sbjct: 625 HKVSPVLRDFLERMLVRDPQERATAQELL 653
Score = 57.8 bits (138), Expect = 3e-08
Identities = 22/44 (50%), Positives = 31/44 (70%)
Query: 66 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQT 109
+KK+K+RPEIS P +F+H +H FD G+F G+P QW +L T
Sbjct: 3 RKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDT 46
>gi|9910476 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 290 bits (741), Expect = 3e-78
Identities = 135/269 (50%), Positives = 201/269 (74%)
Query: 248 MSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQP 307
++ E+ LR +V GDP+ + KIG+G++G V A + +G++VA+K M+L++Q
Sbjct: 385 VTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQ 444
Query: 308 KKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIA 367
++EL+ NE+++MR+ ++ N+V SYLVG+ELWV+ME+L GG+LTD+V++ ++E QIA
Sbjct: 445 RRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIA 504
Query: 368 AVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGT 427
VC LQAL +LH+ VIHRDIKSD+ILL +DG VKL+DFGFCAQI+ + KR ++VGT
Sbjct: 505 TVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGT 564
Query: 428 PYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNP 487
PYWMAPEV++R Y +VDIWSLGIM IEM++GEPPY +++P++A+ + + P+L+N
Sbjct: 565 PYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNS 624
Query: 488 EKLSAIFRDFLNRCLEMDVEKRGSAKELL 516
K+S + RDFL R L D ++R +A+ELL
Sbjct: 625 HKVSPVLRDFLERMLVRDPQERATAQELL 653
Score = 57.8 bits (138), Expect = 3e-08
Identities = 22/44 (50%), Positives = 31/44 (70%)
Query: 66 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQT 109
+KK+K+RPEIS P +F+H +H FD G+F G+P QW +L T
Sbjct: 3 RKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDT 46
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 228 bits (580), Expect = 1e-59
Identities = 117/277 (42%), Positives = 175/277 (63%), Gaps = 12/277 (4%)
Query: 243 KKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMN 302
+++ K DE+ L K P++ + EK+G+G+ G+VY A+ TGQ VAIKQ+
Sbjct: 11 RRQLKKLDEDSLTK--------QPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVP 62
Query: 303 LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVT--ETC 360
++ ++ II EI +M++ +P++V Y SY +LW+VMEY GS++D++
Sbjct: 63 VESDLQE--IIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKT 120
Query: 361 MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSK 420
+ E +IA + + L+ LE+LH + IHRDIK+ NILL +G KL DFG Q+T +K
Sbjct: 121 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK 180
Query: 421 RSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNG 480
R+T++GTP+WMAPEV+ Y DIWSLGI AIEM EG+PPY + +P+RA+++I TN
Sbjct: 181 RNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNP 240
Query: 481 TPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQ 517
P + PE S F DF+ +CL E+R +A +LLQ
Sbjct: 241 PPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQ 277
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 227 bits (578), Expect = 2e-59
Identities = 116/257 (45%), Positives = 168/257 (65%), Gaps = 3/257 (1%)
Query: 262 SVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQ-QPKKELIINEILVMR 320
++ DP++ +T+ E+IG+G+ G V+ +D T Q VAIK ++L++ + + E I EI V+
Sbjct: 16 NIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLS 75
Query: 321 ENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFL 380
+ + + Y SYL G +LW++MEYL GGS D++ DE QIA + +E L+ L++L
Sbjct: 76 QCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYL 135
Query: 381 HSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA 440
HS + IHRDIK+ N+LL G VKL DFG Q+T Q KR+T VGTP+WMAPEV+ + A
Sbjct: 136 HSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSA 195
Query: 441 YGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNR 500
Y K DIWSLGI AIE+ +GEPP + +P+R L+LI N P L + F++F++
Sbjct: 196 YDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG--DFTKSFKEFIDA 253
Query: 501 CLEMDVEKRGSAKELLQ 517
CL D R +AKELL+
Sbjct: 254 CLNKDPSFRPTAKELLK 270
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 224 bits (572), Expect = 1e-58
Identities = 115/254 (45%), Positives = 165/254 (64%), Gaps = 3/254 (1%)
Query: 265 DPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQ-QPKKELIINEILVMRENK 323
DP++ +T+ EKIG+G+ G V+ +D T + VAIK ++L++ + + E I EI V+ +
Sbjct: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
Query: 324 NPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSN 383
+P + Y SYL +LW++MEYL GGS D++ +DE QIA + RE L+ L++LHS
Sbjct: 79 SPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSE 138
Query: 384 QVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGP 443
+ IHRDIK+ N+LL G VKL DFG Q+T Q KR+T VGTP+WMAPEV+ + AY
Sbjct: 139 KKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDS 198
Query: 444 KVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLE 503
K DIWSLGI AIE+ GEPP+ +P++ L+LI N P L+ S ++F+ CL
Sbjct: 199 KADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEG--NYSKPLKEFVEACLN 256
Query: 504 MDVEKRGSAKELLQ 517
+ R +AKELL+
Sbjct: 257 KEPSFRPTAKELLK 270
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 224 bits (572), Expect = 1e-58
Identities = 115/254 (45%), Positives = 165/254 (64%), Gaps = 3/254 (1%)
Query: 265 DPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQ-QPKKELIINEILVMRENK 323
DP++ +T+ EKIG+G+ G V+ +D T + VAIK ++L++ + + E I EI V+ +
Sbjct: 31 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 90
Query: 324 NPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSN 383
+P + Y SYL +LW++MEYL GGS D++ +DE QIA + RE L+ L++LHS
Sbjct: 91 SPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSE 150
Query: 384 QVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGP 443
+ IHRDIK+ N+LL G VKL DFG Q+T Q KR+T VGTP+WMAPEV+ + AY
Sbjct: 151 KKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDS 210
Query: 444 KVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLE 503
K DIWSLGI AIE+ GEPP+ +P++ L+LI N P L+ S ++F+ CL
Sbjct: 211 KADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEG--NYSKPLKEFVEACLN 268
Query: 504 MDVEKRGSAKELLQ 517
+ R +AKELL+
Sbjct: 269 KEPSFRPTAKELLK 282
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 224 bits (572), Expect = 1e-58
Identities = 116/254 (45%), Positives = 166/254 (65%), Gaps = 3/254 (1%)
Query: 265 DPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQ-QPKKELIINEILVMRENK 323
DP++ +T+ ++IG+G+ G VY +D T + VAIK ++L++ + + E I EI V+ +
Sbjct: 15 DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74
Query: 324 NPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSN 383
+P I Y SYL +LW++MEYL GGS D++ ++E IA + RE L+ L++LHS
Sbjct: 75 SPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSE 134
Query: 384 QVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGP 443
+ IHRDIK+ N+LL G VKL DFG Q+T Q KR+T VGTP+WMAPEV+ + AY
Sbjct: 135 RKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDF 194
Query: 444 KVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLE 503
K DIWSLGI AIE+ +GEPP + +P+R L+LI N P L+ S F++F+ CL
Sbjct: 195 KADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH--SKPFKEFVEACLN 252
Query: 504 MDVEKRGSAKELLQ 517
D R +AKELL+
Sbjct: 253 KDPRFRPTAKELLK 266
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 223 bits (568), Expect = 4e-58
Identities = 112/266 (42%), Positives = 170/266 (63%), Gaps = 4/266 (1%)
Query: 254 LEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELII 313
L+KL P++ + EK+G+G+ G+V+ A+ +GQ VAIKQ+ ++ ++ II
Sbjct: 11 LKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQE--II 68
Query: 314 NEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVT--ETCMDEGQIAAVCR 371
EI +M++ +P +V Y SY +LW+VMEY GS++D++ + E +IA + +
Sbjct: 69 KEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILK 128
Query: 372 ECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWM 431
L+ LE+LH + IHRDIK+ NILL +G KL DFG Q+T +KR+T++GTP+WM
Sbjct: 129 STLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWM 188
Query: 432 APEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLS 491
APEV+ Y DIWSLGI +IEM EG+PPY + +P+RA+++I TN P + PE S
Sbjct: 189 APEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWS 248
Query: 492 AIFRDFLNRCLEMDVEKRGSAKELLQ 517
F DF+ +CL + E+R +A +LLQ
Sbjct: 249 DDFTDFVKKCLVKNPEQRATATQLLQ 274
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 204 bits (519), Expect = 2e-52
Identities = 118/297 (39%), Positives = 172/297 (57%), Gaps = 16/297 (5%)
Query: 261 VSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMR 320
VS+ DP+ ++ +++G G G VY A D T + A+K + L + EI ++R
Sbjct: 7 VSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILR 66
Query: 321 ENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALEF 379
E ++PN+V Y+ SYL D LW+ ME+ GGSL ++ T ++E QIA VCRE L+ L
Sbjct: 67 ECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHH 126
Query: 380 LHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEV--VT 437
LHS IHRDIK N+LL + G VKL DFG ++T +KR + +GTPYWMAPEV V
Sbjct: 127 LHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVE 186
Query: 438 RK-AYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNG--TPELQNPEKLSAIF 494
RK Y D+W+LGI AIE+ E +PP + +P+RAL L++ + P+L++ + + F
Sbjct: 187 RKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNF 246
Query: 495 RDFLNRCLEMDVEKRGSAKELLQ--------VRKLRFQVFSNFS--MIAASIPEDCQ 541
FL L + +KR +A++LLQ R L Q+ S + PEDC+
Sbjct: 247 HHFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLLDKASDPHLGTPSPEDCE 303
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 202 bits (513), Expect = 8e-52
Identities = 115/259 (44%), Positives = 163/259 (62%), Gaps = 6/259 (2%)
Query: 265 DPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKN 324
+P++ + ++IG G G VY A +V TG+ AIK + L+ ++ EI++M++ K+
Sbjct: 11 NPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKH 70
Query: 325 PNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALEFLHSN 383
PNIV Y SYL D+LW+ ME+ GGSL D+ T + E QIA V RE LQ L +LHS
Sbjct: 71 PNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSK 130
Query: 384 QVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEV--VTRK-A 440
+HRDIK NILL +G VKL DFG AQIT +KR + +GTPYWMAPEV V RK
Sbjct: 131 GKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGG 190
Query: 441 YGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNG--TPELQNPEKLSAIFRDFL 498
Y D+W++GI AIE+ E +PP + +P+RAL+L+ + P+L++ K S F F+
Sbjct: 191 YNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFV 250
Query: 499 NRCLEMDVEKRGSAKELLQ 517
L + +KR +A++LLQ
Sbjct: 251 KMALTKNPKKRPTAEKLLQ 269
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 200 bits (508), Expect = 3e-51
Identities = 107/278 (38%), Positives = 164/278 (58%), Gaps = 7/278 (2%)
Query: 247 KMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQ 306
K+ E+ ++ + +P+ + ++G GA G VY A + T A K ++ + +
Sbjct: 11 KLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSE 70
Query: 307 PKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTET--CMDEG 364
+ E + EI ++ +PNIV LD++ + LW+++E+ AGG++ V+ E + E
Sbjct: 71 EELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTES 130
Query: 365 QIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTM 424
QI VC++ L AL +LH N++IHRD+K+ NIL +DG +KL DFG A+ T +R +
Sbjct: 131 QIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSF 190
Query: 425 VGTPYWMAPEVV-----TRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATN 479
+GTPYWMAPEVV + Y K D+WSLGI IEM E EPP+ NP+R L IA +
Sbjct: 191 IGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKS 250
Query: 480 GTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQ 517
P L P + S+ F+DFL +CLE +V+ R + +LLQ
Sbjct: 251 EPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQ 288
>gi|145275208 myosin IIIA [Homo sapiens]
Length = 1616
Score = 199 bits (507), Expect = 4e-51
Identities = 108/268 (40%), Positives = 159/268 (59%), Gaps = 15/268 (5%)
Query: 265 DPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKN 324
DP + E IG+G G V+ ++ GQ+ A+K ++ +E+ ++ + +
Sbjct: 16 DPSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDEEIEAEYNILKALSDH 75
Query: 325 PNIVNYLDSYLV-----GDELWVVMEYLAGGSLTDVVTETC-----MDEGQIAAVCRECL 374
PN+V + Y GD+LW+V+E +GGS+TD+V M E IA + E L
Sbjct: 76 PNVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEAL 135
Query: 375 QALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPE 434
L+ LH+N+ IHRD+K +NILL +G VKL DFG AQ+T + +R+T VGTP+WMAPE
Sbjct: 136 MGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPE 195
Query: 435 VVTRK-----AYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEK 489
V+ + Y + D WSLGI AIE+ +G+PP + +P+RAL+ I N P+L+ PE
Sbjct: 196 VIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPEL 255
Query: 490 LSAIFRDFLNRCLEMDVEKRGSAKELLQ 517
SA F DF+++CL D EKR + ELLQ
Sbjct: 256 WSAEFNDFISKCLTKDYEKRPTVSELLQ 283
Score = 32.3 bits (72), Expect = 1.2
Identities = 47/215 (21%), Positives = 86/215 (40%), Gaps = 17/215 (7%)
Query: 116 EQKKNPQAVLDVLEFYNSKKTSNSQK-----YMSFTDKSAEDYNSSNALNVKAVSETPAV 170
E ++V D+ E N +K + Y +T++ + + + L KA+SE P+
Sbjct: 1210 EVSPKQKSVKDLEENSNLRKVEKEEAMIQSYYQRYTEERNCEESKAAYLERKAISERPSY 1269
Query: 171 PPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTT 230
P E++ T P ++ R S+Y + + +PI E
Sbjct: 1270 PVPWLAENETSFKKTLEPTLSQR-----SIYQNANSMEKEKKTSVVTQRAPICSQEEGR- 1323
Query: 231 PPDALTRNTEKQKK-KPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMD 289
L T K+++ +P +E E+ ++ V + + Y R +++ + +
Sbjct: 1324 --GRLRHETVKERQVEPVTQAQE--EEDKAAVFIQSKYRGYKRRQQLRKDKMSSFKHQRI 1379
Query: 290 VATGQEVAIKQMNLQQQPKKELIINEILVMRENKN 324
V T EVA NL P K IN I ++NK+
Sbjct: 1380 VTTPTEVARNTHNLYSYPTKHEEINNI-KKKDNKD 1413
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 199 bits (505), Expect = 7e-51
Identities = 111/258 (43%), Positives = 159/258 (61%), Gaps = 6/258 (2%)
Query: 265 DPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKN 324
+P++ Y +++G G G VY A +V TG+ A+K + L+ LI EI +++E K+
Sbjct: 15 NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKH 74
Query: 325 PNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALEFLHSN 383
NIV Y SYL ++LW+ MEY GGSL D+ T + E QIA VCRE LQ L +LH+
Sbjct: 75 CNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTK 134
Query: 384 QVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT---RKA 440
+HRDIK NILL G VKL DFG A+IT +KR + +GTPYWMAPEV
Sbjct: 135 GKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGG 194
Query: 441 YGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNG--TPELQNPEKLSAIFRDFL 498
Y DIW++GI AIE+ E +PP + +P+RAL+L++ + P+L++ K S+ F +F+
Sbjct: 195 YNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFV 254
Query: 499 NRCLEMDVEKRGSAKELL 516
L + +KR +A+ LL
Sbjct: 255 KIALTKNPKKRPTAERLL 272
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.130 0.376
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,144,099
Number of Sequences: 37866
Number of extensions: 1256013
Number of successful extensions: 8284
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 777
Number of HSP's successfully gapped in prelim test: 184
Number of HSP's that attempted gapping in prelim test: 5007
Number of HSP's gapped (non-prelim): 1777
length of query: 553
length of database: 18,247,518
effective HSP length: 107
effective length of query: 446
effective length of database: 14,195,856
effective search space: 6331351776
effective search space used: 6331351776
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.