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Search of human proteins with 189571638
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|189571638 sulfatase 1 [Homo sapiens]
(871 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|189571643 sulfatase 1 [Homo sapiens] 1826 0.0
gi|189571641 sulfatase 1 [Homo sapiens] 1826 0.0
gi|189571638 sulfatase 1 [Homo sapiens] 1826 0.0
gi|189571636 sulfatase 1 [Homo sapiens] 1826 0.0
gi|240255483 sulfatase 2 isoform a precursor [Homo sapiens] 1214 0.0
gi|29789100 sulfatase 2 isoform a precursor [Homo sapiens] 1214 0.0
gi|240255478 sulfatase 2 isoform b precursor [Homo sapiens] 1206 0.0
gi|4504061 glucosamine (N-acetyl)-6-sulfatase precursor [Homo sa... 312 1e-84
gi|39930577 arylsulfatase K [Homo sapiens] 91 5e-18
gi|4557659 iduronate-2-sulfatase isoform a precursor [Homo sapiens] 77 5e-14
gi|4503899 galactosamine (N-acetyl)-6-sulfate sulfatase precurso... 68 4e-11
gi|109389362 arylsulfatase J [Homo sapiens] 64 5e-10
gi|59797060 arylsulfatase family, member I [Homo sapiens] 61 4e-09
gi|5360208 iduronate-2-sulfatase isoform b precursor [Homo sapiens] 61 5e-09
gi|4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo sap... 57 1e-07
gi|53831991 steryl-sulfatase precursor [Homo sapiens] 55 3e-07
gi|38569407 arylsulfatase B isoform 2 precursor [Homo sapiens] 55 3e-07
gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens] 55 3e-07
gi|31742482 arylsulfatase F precursor [Homo sapiens] 50 9e-06
gi|71852584 arylsulfatase D isoform a precursor [Homo sapiens] 48 5e-05
gi|45430057 Arylsulfatase G [Homo sapiens] 48 5e-05
gi|148746195 trichohyalin [Homo sapiens] 47 6e-05
gi|58743319 arylsulfatase family, member H [Homo sapiens] 47 8e-05
gi|157266309 arylsulfatase E precursor [Homo sapiens] 47 1e-04
gi|146229331 arylsulfatase A isoform a precursor [Homo sapiens] 46 1e-04
gi|146229329 arylsulfatase A isoform a precursor [Homo sapiens] 46 1e-04
gi|146229327 arylsulfatase A isoform b [Homo sapiens] 46 1e-04
gi|146229324 arylsulfatase A isoform a precursor [Homo sapiens] 46 1e-04
gi|6005990 arylsulfatase A isoform a precursor [Homo sapiens] 46 1e-04
gi|239508778 PREDICTED: hypothetical protein, partial [Homo sapi... 42 0.002
>gi|189571643 sulfatase 1 [Homo sapiens]
Length = 871
Score = 1826 bits (4729), Expect = 0.0
Identities = 871/871 (100%), Positives = 871/871 (100%)
Query: 1 MKYSCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSL 60
MKYSCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSL
Sbjct: 1 MKYSCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSL 60
Query: 61 QVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAM 120
QVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAM
Sbjct: 61 QVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAM 120
Query: 121 HEPRTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGWREWLGLIKNSRFYNYTVCRNGIKE 180
HEPRTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGWREWLGLIKNSRFYNYTVCRNGIKE
Sbjct: 121 HEPRTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGWREWLGLIKNSRFYNYTVCRNGIKE 180
Query: 181 KHGFDYAKDYFTDLITNESINYFKMSKRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPN 240
KHGFDYAKDYFTDLITNESINYFKMSKRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPN
Sbjct: 181 KHGFDYAKDYFTDLITNESINYFKMSKRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPN 240
Query: 241 ASQHITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNML 300
ASQHITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNML
Sbjct: 241 ASQHITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNML 300
Query: 301 VETGELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSVEPGSIVPQIVL 360
VETGELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSVEPGSIVPQIVL
Sbjct: 301 VETGELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSVEPGSIVPQIVL 360
Query: 361 NIDLAPTILDIAGLDTPPDVDGKSVLKLLDPEKPGNRFRTNKKAKIWRDTFLVERGKFLR 420
NIDLAPTILDIAGLDTPPDVDGKSVLKLLDPEKPGNRFRTNKKAKIWRDTFLVERGKFLR
Sbjct: 361 NIDLAPTILDIAGLDTPPDVDGKSVLKLLDPEKPGNRFRTNKKAKIWRDTFLVERGKFLR 420
Query: 421 KKEESSKNIQQSNHLPKYERVKELCQQARYQTACEQPGQKWQCIEDTSGKLRIHKCKGPS 480
KKEESSKNIQQSNHLPKYERVKELCQQARYQTACEQPGQKWQCIEDTSGKLRIHKCKGPS
Sbjct: 421 KKEESSKNIQQSNHLPKYERVKELCQQARYQTACEQPGQKWQCIEDTSGKLRIHKCKGPS 480
Query: 481 DLLTVRQSTRNLYARGFHDKDKECSCRESGYRASRSQRKSQRQFLRNQGTPKYKPRFVHT 540
DLLTVRQSTRNLYARGFHDKDKECSCRESGYRASRSQRKSQRQFLRNQGTPKYKPRFVHT
Sbjct: 481 DLLTVRQSTRNLYARGFHDKDKECSCRESGYRASRSQRKSQRQFLRNQGTPKYKPRFVHT 540
Query: 541 RQTRSLSVEFEGEIYDINLEEEEELQVLQPRNIAKRHDEGHKGPRDLQASSGGNRGRMLA 600
RQTRSLSVEFEGEIYDINLEEEEELQVLQPRNIAKRHDEGHKGPRDLQASSGGNRGRMLA
Sbjct: 541 RQTRSLSVEFEGEIYDINLEEEEELQVLQPRNIAKRHDEGHKGPRDLQASSGGNRGRMLA 600
Query: 601 DSSNAVGPPTTVRVTHKCFILPNDSIHCERELYQSARAWKDHKAYIDKEIEALQDKIKNL 660
DSSNAVGPPTTVRVTHKCFILPNDSIHCERELYQSARAWKDHKAYIDKEIEALQDKIKNL
Sbjct: 601 DSSNAVGPPTTVRVTHKCFILPNDSIHCERELYQSARAWKDHKAYIDKEIEALQDKIKNL 660
Query: 661 REVRGHLKRRKPEECSCSKQSYYNKEKGVKKQEKLKSHLHPFKEAAQEVDSKLQLFKENN 720
REVRGHLKRRKPEECSCSKQSYYNKEKGVKKQEKLKSHLHPFKEAAQEVDSKLQLFKENN
Sbjct: 661 REVRGHLKRRKPEECSCSKQSYYNKEKGVKKQEKLKSHLHPFKEAAQEVDSKLQLFKENN 720
Query: 721 RRRKKERKEKRRQRKGEECSLPGLTCFTHDNNHWQTAPFWNLGSFCACTSSNNNTYWCLR 780
RRRKKERKEKRRQRKGEECSLPGLTCFTHDNNHWQTAPFWNLGSFCACTSSNNNTYWCLR
Sbjct: 721 RRRKKERKEKRRQRKGEECSLPGLTCFTHDNNHWQTAPFWNLGSFCACTSSNNNTYWCLR 780
Query: 781 TVNETHNFLFCEFATGFLEYFDMNTDPYQLTNTVHTVERGILNQLHVQLMELRSCQGYKQ 840
TVNETHNFLFCEFATGFLEYFDMNTDPYQLTNTVHTVERGILNQLHVQLMELRSCQGYKQ
Sbjct: 781 TVNETHNFLFCEFATGFLEYFDMNTDPYQLTNTVHTVERGILNQLHVQLMELRSCQGYKQ 840
Query: 841 CNPRPKNLDVGNKDGGSYDLHRGQLWDGWEG 871
CNPRPKNLDVGNKDGGSYDLHRGQLWDGWEG
Sbjct: 841 CNPRPKNLDVGNKDGGSYDLHRGQLWDGWEG 871
>gi|189571641 sulfatase 1 [Homo sapiens]
Length = 871
Score = 1826 bits (4729), Expect = 0.0
Identities = 871/871 (100%), Positives = 871/871 (100%)
Query: 1 MKYSCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSL 60
MKYSCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSL
Sbjct: 1 MKYSCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSL 60
Query: 61 QVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAM 120
QVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAM
Sbjct: 61 QVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAM 120
Query: 121 HEPRTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGWREWLGLIKNSRFYNYTVCRNGIKE 180
HEPRTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGWREWLGLIKNSRFYNYTVCRNGIKE
Sbjct: 121 HEPRTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGWREWLGLIKNSRFYNYTVCRNGIKE 180
Query: 181 KHGFDYAKDYFTDLITNESINYFKMSKRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPN 240
KHGFDYAKDYFTDLITNESINYFKMSKRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPN
Sbjct: 181 KHGFDYAKDYFTDLITNESINYFKMSKRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPN 240
Query: 241 ASQHITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNML 300
ASQHITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNML
Sbjct: 241 ASQHITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNML 300
Query: 301 VETGELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSVEPGSIVPQIVL 360
VETGELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSVEPGSIVPQIVL
Sbjct: 301 VETGELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSVEPGSIVPQIVL 360
Query: 361 NIDLAPTILDIAGLDTPPDVDGKSVLKLLDPEKPGNRFRTNKKAKIWRDTFLVERGKFLR 420
NIDLAPTILDIAGLDTPPDVDGKSVLKLLDPEKPGNRFRTNKKAKIWRDTFLVERGKFLR
Sbjct: 361 NIDLAPTILDIAGLDTPPDVDGKSVLKLLDPEKPGNRFRTNKKAKIWRDTFLVERGKFLR 420
Query: 421 KKEESSKNIQQSNHLPKYERVKELCQQARYQTACEQPGQKWQCIEDTSGKLRIHKCKGPS 480
KKEESSKNIQQSNHLPKYERVKELCQQARYQTACEQPGQKWQCIEDTSGKLRIHKCKGPS
Sbjct: 421 KKEESSKNIQQSNHLPKYERVKELCQQARYQTACEQPGQKWQCIEDTSGKLRIHKCKGPS 480
Query: 481 DLLTVRQSTRNLYARGFHDKDKECSCRESGYRASRSQRKSQRQFLRNQGTPKYKPRFVHT 540
DLLTVRQSTRNLYARGFHDKDKECSCRESGYRASRSQRKSQRQFLRNQGTPKYKPRFVHT
Sbjct: 481 DLLTVRQSTRNLYARGFHDKDKECSCRESGYRASRSQRKSQRQFLRNQGTPKYKPRFVHT 540
Query: 541 RQTRSLSVEFEGEIYDINLEEEEELQVLQPRNIAKRHDEGHKGPRDLQASSGGNRGRMLA 600
RQTRSLSVEFEGEIYDINLEEEEELQVLQPRNIAKRHDEGHKGPRDLQASSGGNRGRMLA
Sbjct: 541 RQTRSLSVEFEGEIYDINLEEEEELQVLQPRNIAKRHDEGHKGPRDLQASSGGNRGRMLA 600
Query: 601 DSSNAVGPPTTVRVTHKCFILPNDSIHCERELYQSARAWKDHKAYIDKEIEALQDKIKNL 660
DSSNAVGPPTTVRVTHKCFILPNDSIHCERELYQSARAWKDHKAYIDKEIEALQDKIKNL
Sbjct: 601 DSSNAVGPPTTVRVTHKCFILPNDSIHCERELYQSARAWKDHKAYIDKEIEALQDKIKNL 660
Query: 661 REVRGHLKRRKPEECSCSKQSYYNKEKGVKKQEKLKSHLHPFKEAAQEVDSKLQLFKENN 720
REVRGHLKRRKPEECSCSKQSYYNKEKGVKKQEKLKSHLHPFKEAAQEVDSKLQLFKENN
Sbjct: 661 REVRGHLKRRKPEECSCSKQSYYNKEKGVKKQEKLKSHLHPFKEAAQEVDSKLQLFKENN 720
Query: 721 RRRKKERKEKRRQRKGEECSLPGLTCFTHDNNHWQTAPFWNLGSFCACTSSNNNTYWCLR 780
RRRKKERKEKRRQRKGEECSLPGLTCFTHDNNHWQTAPFWNLGSFCACTSSNNNTYWCLR
Sbjct: 721 RRRKKERKEKRRQRKGEECSLPGLTCFTHDNNHWQTAPFWNLGSFCACTSSNNNTYWCLR 780
Query: 781 TVNETHNFLFCEFATGFLEYFDMNTDPYQLTNTVHTVERGILNQLHVQLMELRSCQGYKQ 840
TVNETHNFLFCEFATGFLEYFDMNTDPYQLTNTVHTVERGILNQLHVQLMELRSCQGYKQ
Sbjct: 781 TVNETHNFLFCEFATGFLEYFDMNTDPYQLTNTVHTVERGILNQLHVQLMELRSCQGYKQ 840
Query: 841 CNPRPKNLDVGNKDGGSYDLHRGQLWDGWEG 871
CNPRPKNLDVGNKDGGSYDLHRGQLWDGWEG
Sbjct: 841 CNPRPKNLDVGNKDGGSYDLHRGQLWDGWEG 871
>gi|189571638 sulfatase 1 [Homo sapiens]
Length = 871
Score = 1826 bits (4729), Expect = 0.0
Identities = 871/871 (100%), Positives = 871/871 (100%)
Query: 1 MKYSCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSL 60
MKYSCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSL
Sbjct: 1 MKYSCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSL 60
Query: 61 QVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAM 120
QVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAM
Sbjct: 61 QVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAM 120
Query: 121 HEPRTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGWREWLGLIKNSRFYNYTVCRNGIKE 180
HEPRTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGWREWLGLIKNSRFYNYTVCRNGIKE
Sbjct: 121 HEPRTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGWREWLGLIKNSRFYNYTVCRNGIKE 180
Query: 181 KHGFDYAKDYFTDLITNESINYFKMSKRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPN 240
KHGFDYAKDYFTDLITNESINYFKMSKRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPN
Sbjct: 181 KHGFDYAKDYFTDLITNESINYFKMSKRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPN 240
Query: 241 ASQHITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNML 300
ASQHITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNML
Sbjct: 241 ASQHITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNML 300
Query: 301 VETGELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSVEPGSIVPQIVL 360
VETGELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSVEPGSIVPQIVL
Sbjct: 301 VETGELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSVEPGSIVPQIVL 360
Query: 361 NIDLAPTILDIAGLDTPPDVDGKSVLKLLDPEKPGNRFRTNKKAKIWRDTFLVERGKFLR 420
NIDLAPTILDIAGLDTPPDVDGKSVLKLLDPEKPGNRFRTNKKAKIWRDTFLVERGKFLR
Sbjct: 361 NIDLAPTILDIAGLDTPPDVDGKSVLKLLDPEKPGNRFRTNKKAKIWRDTFLVERGKFLR 420
Query: 421 KKEESSKNIQQSNHLPKYERVKELCQQARYQTACEQPGQKWQCIEDTSGKLRIHKCKGPS 480
KKEESSKNIQQSNHLPKYERVKELCQQARYQTACEQPGQKWQCIEDTSGKLRIHKCKGPS
Sbjct: 421 KKEESSKNIQQSNHLPKYERVKELCQQARYQTACEQPGQKWQCIEDTSGKLRIHKCKGPS 480
Query: 481 DLLTVRQSTRNLYARGFHDKDKECSCRESGYRASRSQRKSQRQFLRNQGTPKYKPRFVHT 540
DLLTVRQSTRNLYARGFHDKDKECSCRESGYRASRSQRKSQRQFLRNQGTPKYKPRFVHT
Sbjct: 481 DLLTVRQSTRNLYARGFHDKDKECSCRESGYRASRSQRKSQRQFLRNQGTPKYKPRFVHT 540
Query: 541 RQTRSLSVEFEGEIYDINLEEEEELQVLQPRNIAKRHDEGHKGPRDLQASSGGNRGRMLA 600
RQTRSLSVEFEGEIYDINLEEEEELQVLQPRNIAKRHDEGHKGPRDLQASSGGNRGRMLA
Sbjct: 541 RQTRSLSVEFEGEIYDINLEEEEELQVLQPRNIAKRHDEGHKGPRDLQASSGGNRGRMLA 600
Query: 601 DSSNAVGPPTTVRVTHKCFILPNDSIHCERELYQSARAWKDHKAYIDKEIEALQDKIKNL 660
DSSNAVGPPTTVRVTHKCFILPNDSIHCERELYQSARAWKDHKAYIDKEIEALQDKIKNL
Sbjct: 601 DSSNAVGPPTTVRVTHKCFILPNDSIHCERELYQSARAWKDHKAYIDKEIEALQDKIKNL 660
Query: 661 REVRGHLKRRKPEECSCSKQSYYNKEKGVKKQEKLKSHLHPFKEAAQEVDSKLQLFKENN 720
REVRGHLKRRKPEECSCSKQSYYNKEKGVKKQEKLKSHLHPFKEAAQEVDSKLQLFKENN
Sbjct: 661 REVRGHLKRRKPEECSCSKQSYYNKEKGVKKQEKLKSHLHPFKEAAQEVDSKLQLFKENN 720
Query: 721 RRRKKERKEKRRQRKGEECSLPGLTCFTHDNNHWQTAPFWNLGSFCACTSSNNNTYWCLR 780
RRRKKERKEKRRQRKGEECSLPGLTCFTHDNNHWQTAPFWNLGSFCACTSSNNNTYWCLR
Sbjct: 721 RRRKKERKEKRRQRKGEECSLPGLTCFTHDNNHWQTAPFWNLGSFCACTSSNNNTYWCLR 780
Query: 781 TVNETHNFLFCEFATGFLEYFDMNTDPYQLTNTVHTVERGILNQLHVQLMELRSCQGYKQ 840
TVNETHNFLFCEFATGFLEYFDMNTDPYQLTNTVHTVERGILNQLHVQLMELRSCQGYKQ
Sbjct: 781 TVNETHNFLFCEFATGFLEYFDMNTDPYQLTNTVHTVERGILNQLHVQLMELRSCQGYKQ 840
Query: 841 CNPRPKNLDVGNKDGGSYDLHRGQLWDGWEG 871
CNPRPKNLDVGNKDGGSYDLHRGQLWDGWEG
Sbjct: 841 CNPRPKNLDVGNKDGGSYDLHRGQLWDGWEG 871
>gi|189571636 sulfatase 1 [Homo sapiens]
Length = 871
Score = 1826 bits (4729), Expect = 0.0
Identities = 871/871 (100%), Positives = 871/871 (100%)
Query: 1 MKYSCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSL 60
MKYSCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSL
Sbjct: 1 MKYSCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSL 60
Query: 61 QVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAM 120
QVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAM
Sbjct: 61 QVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAM 120
Query: 121 HEPRTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGWREWLGLIKNSRFYNYTVCRNGIKE 180
HEPRTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGWREWLGLIKNSRFYNYTVCRNGIKE
Sbjct: 121 HEPRTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGWREWLGLIKNSRFYNYTVCRNGIKE 180
Query: 181 KHGFDYAKDYFTDLITNESINYFKMSKRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPN 240
KHGFDYAKDYFTDLITNESINYFKMSKRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPN
Sbjct: 181 KHGFDYAKDYFTDLITNESINYFKMSKRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPN 240
Query: 241 ASQHITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNML 300
ASQHITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNML
Sbjct: 241 ASQHITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNML 300
Query: 301 VETGELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSVEPGSIVPQIVL 360
VETGELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSVEPGSIVPQIVL
Sbjct: 301 VETGELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSVEPGSIVPQIVL 360
Query: 361 NIDLAPTILDIAGLDTPPDVDGKSVLKLLDPEKPGNRFRTNKKAKIWRDTFLVERGKFLR 420
NIDLAPTILDIAGLDTPPDVDGKSVLKLLDPEKPGNRFRTNKKAKIWRDTFLVERGKFLR
Sbjct: 361 NIDLAPTILDIAGLDTPPDVDGKSVLKLLDPEKPGNRFRTNKKAKIWRDTFLVERGKFLR 420
Query: 421 KKEESSKNIQQSNHLPKYERVKELCQQARYQTACEQPGQKWQCIEDTSGKLRIHKCKGPS 480
KKEESSKNIQQSNHLPKYERVKELCQQARYQTACEQPGQKWQCIEDTSGKLRIHKCKGPS
Sbjct: 421 KKEESSKNIQQSNHLPKYERVKELCQQARYQTACEQPGQKWQCIEDTSGKLRIHKCKGPS 480
Query: 481 DLLTVRQSTRNLYARGFHDKDKECSCRESGYRASRSQRKSQRQFLRNQGTPKYKPRFVHT 540
DLLTVRQSTRNLYARGFHDKDKECSCRESGYRASRSQRKSQRQFLRNQGTPKYKPRFVHT
Sbjct: 481 DLLTVRQSTRNLYARGFHDKDKECSCRESGYRASRSQRKSQRQFLRNQGTPKYKPRFVHT 540
Query: 541 RQTRSLSVEFEGEIYDINLEEEEELQVLQPRNIAKRHDEGHKGPRDLQASSGGNRGRMLA 600
RQTRSLSVEFEGEIYDINLEEEEELQVLQPRNIAKRHDEGHKGPRDLQASSGGNRGRMLA
Sbjct: 541 RQTRSLSVEFEGEIYDINLEEEEELQVLQPRNIAKRHDEGHKGPRDLQASSGGNRGRMLA 600
Query: 601 DSSNAVGPPTTVRVTHKCFILPNDSIHCERELYQSARAWKDHKAYIDKEIEALQDKIKNL 660
DSSNAVGPPTTVRVTHKCFILPNDSIHCERELYQSARAWKDHKAYIDKEIEALQDKIKNL
Sbjct: 601 DSSNAVGPPTTVRVTHKCFILPNDSIHCERELYQSARAWKDHKAYIDKEIEALQDKIKNL 660
Query: 661 REVRGHLKRRKPEECSCSKQSYYNKEKGVKKQEKLKSHLHPFKEAAQEVDSKLQLFKENN 720
REVRGHLKRRKPEECSCSKQSYYNKEKGVKKQEKLKSHLHPFKEAAQEVDSKLQLFKENN
Sbjct: 661 REVRGHLKRRKPEECSCSKQSYYNKEKGVKKQEKLKSHLHPFKEAAQEVDSKLQLFKENN 720
Query: 721 RRRKKERKEKRRQRKGEECSLPGLTCFTHDNNHWQTAPFWNLGSFCACTSSNNNTYWCLR 780
RRRKKERKEKRRQRKGEECSLPGLTCFTHDNNHWQTAPFWNLGSFCACTSSNNNTYWCLR
Sbjct: 721 RRRKKERKEKRRQRKGEECSLPGLTCFTHDNNHWQTAPFWNLGSFCACTSSNNNTYWCLR 780
Query: 781 TVNETHNFLFCEFATGFLEYFDMNTDPYQLTNTVHTVERGILNQLHVQLMELRSCQGYKQ 840
TVNETHNFLFCEFATGFLEYFDMNTDPYQLTNTVHTVERGILNQLHVQLMELRSCQGYKQ
Sbjct: 781 TVNETHNFLFCEFATGFLEYFDMNTDPYQLTNTVHTVERGILNQLHVQLMELRSCQGYKQ 840
Query: 841 CNPRPKNLDVGNKDGGSYDLHRGQLWDGWEG 871
CNPRPKNLDVGNKDGGSYDLHRGQLWDGWEG
Sbjct: 841 CNPRPKNLDVGNKDGGSYDLHRGQLWDGWEG 871
>gi|240255483 sulfatase 2 isoform a precursor [Homo sapiens]
Length = 870
Score = 1214 bits (3142), Expect = 0.0
Identities = 579/891 (64%), Positives = 699/891 (78%), Gaps = 51/891 (5%)
Query: 7 ALVLAVLGT---ELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSLQVM 63
+LVL +L LLG + + R +GR Q++R+NIRPNIILVLTDDQDVELGS+QVM
Sbjct: 5 SLVLCLLSATVFSLLGGSSAFLSHHRLKGRFQRDRRNIRPNIILVLTDDQDVELGSMQVM 64
Query: 64 NKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAMHEP 123
NKTR+IME GGA FINAFVTTPMCCPSRSS+LTGKYVHNHN YTNNENCSSPSWQA HE
Sbjct: 65 NKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTGKYVHNHNTYTNNENCSSPSWQAQHES 124
Query: 124 RTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGWREWLGLIKNSRFYNYTVCRNGIKEKHG 183
RTFAVYLN+TGYRTAFFGKYLNEYNGSY+PPGW+EW+GL+KNSRFYNYT+CRNG+KEKHG
Sbjct: 125 RTFAVYLNSTGYRTAFFGKYLNEYNGSYVPPGWKEWVGLLKNSRFYNYTLCRNGVKEKHG 184
Query: 184 FDYAKDYFTDLITNESINYFKMSKRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPNASQ 243
DY+KDY TDLITN+S+++F+ SK+MYPHRPV+MVISHAAPHGPEDSAPQ+S+L+PNASQ
Sbjct: 185 SDYSKDYLTDLITNDSVSFFRTSKKMYPHRPVLMVISHAAPHGPEDSAPQYSRLFPNASQ 244
Query: 244 HITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNMLVET 303
HITPSYNYAPN DKHWIM+YTGPM PIHMEFTN+LQRKRLQTLMSVDDS+E +YNMLVET
Sbjct: 245 HITPSYNYAPNPDKHWIMRYTGPMKPIHMEFTNMLQRKRLQTLMSVDDSMETIYNMLVET 304
Query: 304 GELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSVEPGSIVPQIVLNID 363
GEL+NTYI+YTADHGYHIGQFGLVKGKSMPY+FDIRVPF++RGP+VE G + P IVLNID
Sbjct: 305 GELDNTYIVYTADHGYHIGQFGLVKGKSMPYEFDIRVPFYVRGPNVEAGCLNPHIVLNID 364
Query: 364 LAPTILDIAGLDTPPDVDGKSVLKLLDPEKPGNRFRTNKKAKIWRDTFLVERGKFLRKKE 423
LAPTILDIAGLD P D+DGKS+LKLLD E+P NRF KK ++WRD+FLVERGK L K++
Sbjct: 365 LAPTILDIAGLDIPADMDGKSILKLLDTERPVNRFHLKKKMRVWRDSFLVERGKLLHKRD 424
Query: 424 ESSKNIQQSNHLPKYERVKELCQQARYQTACEQPGQKWQCIEDTSGKLRIHKCKGPSDLL 483
+ Q+ N LPKY+RVK+LCQ+A YQTACEQ GQKWQC+ED +GKL++HKCKGP L
Sbjct: 425 NDKVDAQEENFLPKYQRVKDLCQRAEYQTACEQLGQKWQCVEDATGKLKLHKCKGPMRLG 484
Query: 484 TVRQSTRNLYARGFHDKDKECSCRESGYRASRSQRKSQRQFLRNQGTPKYKPRFVHTRQT 543
R + NL + + + C+C Y+ S + R+ ++ F + KYK +V +R
Sbjct: 485 GSR-ALSNLVPKYYGQGSEACTCDSGDYKLSLAGRR-KKLFKK-----KYKASYVRSRSI 537
Query: 544 RSLSVEFEGEIYDINLEEEEELQVLQPRNIAKRHDEGHKGPRDLQASSGGNRGRMLADSS 603
RS+++E +G +Y + L + QPRN+ KRH G P D GG D S
Sbjct: 538 RSVAIEVDGRVYHVGLGD-----AAQPRNLTKRHWPG--APEDQDDKDGG-------DFS 583
Query: 604 NAVGPP-----TTVRVTHKCFILPNDSIHCERELYQSARAWKDHKAYIDKEIEALQDKIK 658
G P ++VTH+C+IL ND++ C+ +LY+S +AWKDHK +ID EIE LQ+KIK
Sbjct: 584 GTGGLPDYSAANPIKVTHRCYILENDTVQCDLDLYKSLQAWKDHKLHIDHEIETLQNKIK 643
Query: 659 NLREVRGHLKRRKPEECSCSKQSYYNKEKGVKKQEKLKSHLHPFKEAAQEVDSKLQLFKE 718
NLREVRGHLK+++PEEC C K SY+ + KG K S LHPF++ QE D K+ L +E
Sbjct: 644 NLREVRGHLKKKRPEECDCHKISYHTQHKGRLKHR--GSSLHPFRKGLQEKD-KVWLLRE 700
Query: 719 NNRRRKKERKEKRRQRKGEECSLPGLTCFTHDNNHWQTAPFWNLGSFCACTSSNNNTYWC 778
+R+KK RK +R + + CS+PGLTCFTHDN HWQTAPFW LG FCACTS+NNNTYWC
Sbjct: 701 -QKRKKKLRKLLKRLQNNDTCSMPGLTCFTHDNQHWQTAPFWTLGPFCACTSANNNTYWC 759
Query: 779 LRTVNETHNFLFCEFATGFLEYFDMNTDPYQLTNTVHTVERGILNQLHVQLMELRSCQGY 838
+RT+NETHNFLFCEFATGFLEYFD+NTDPYQL N V+T++R +LNQLHVQLMELRSC+GY
Sbjct: 760 MRTINETHNFLFCEFATGFLEYFDLNTDPYQLMNAVNTLDRDVLNQLHVQLMELRSCKGY 819
Query: 839 KQCNPRPKNLDVGNKDGGSYDLHR------------------GQLWDGWEG 871
KQCNPR +N+D+G KDGGSY+ +R GQLW+GWEG
Sbjct: 820 KQCNPRTRNMDLGLKDGGSYEQYRQFQRRKWPEMKRPSSKSLGQLWEGWEG 870
>gi|29789100 sulfatase 2 isoform a precursor [Homo sapiens]
Length = 870
Score = 1214 bits (3142), Expect = 0.0
Identities = 579/891 (64%), Positives = 699/891 (78%), Gaps = 51/891 (5%)
Query: 7 ALVLAVLGT---ELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSLQVM 63
+LVL +L LLG + + R +GR Q++R+NIRPNIILVLTDDQDVELGS+QVM
Sbjct: 5 SLVLCLLSATVFSLLGGSSAFLSHHRLKGRFQRDRRNIRPNIILVLTDDQDVELGSMQVM 64
Query: 64 NKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAMHEP 123
NKTR+IME GGA FINAFVTTPMCCPSRSS+LTGKYVHNHN YTNNENCSSPSWQA HE
Sbjct: 65 NKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTGKYVHNHNTYTNNENCSSPSWQAQHES 124
Query: 124 RTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGWREWLGLIKNSRFYNYTVCRNGIKEKHG 183
RTFAVYLN+TGYRTAFFGKYLNEYNGSY+PPGW+EW+GL+KNSRFYNYT+CRNG+KEKHG
Sbjct: 125 RTFAVYLNSTGYRTAFFGKYLNEYNGSYVPPGWKEWVGLLKNSRFYNYTLCRNGVKEKHG 184
Query: 184 FDYAKDYFTDLITNESINYFKMSKRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPNASQ 243
DY+KDY TDLITN+S+++F+ SK+MYPHRPV+MVISHAAPHGPEDSAPQ+S+L+PNASQ
Sbjct: 185 SDYSKDYLTDLITNDSVSFFRTSKKMYPHRPVLMVISHAAPHGPEDSAPQYSRLFPNASQ 244
Query: 244 HITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNMLVET 303
HITPSYNYAPN DKHWIM+YTGPM PIHMEFTN+LQRKRLQTLMSVDDS+E +YNMLVET
Sbjct: 245 HITPSYNYAPNPDKHWIMRYTGPMKPIHMEFTNMLQRKRLQTLMSVDDSMETIYNMLVET 304
Query: 304 GELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSVEPGSIVPQIVLNID 363
GEL+NTYI+YTADHGYHIGQFGLVKGKSMPY+FDIRVPF++RGP+VE G + P IVLNID
Sbjct: 305 GELDNTYIVYTADHGYHIGQFGLVKGKSMPYEFDIRVPFYVRGPNVEAGCLNPHIVLNID 364
Query: 364 LAPTILDIAGLDTPPDVDGKSVLKLLDPEKPGNRFRTNKKAKIWRDTFLVERGKFLRKKE 423
LAPTILDIAGLD P D+DGKS+LKLLD E+P NRF KK ++WRD+FLVERGK L K++
Sbjct: 365 LAPTILDIAGLDIPADMDGKSILKLLDTERPVNRFHLKKKMRVWRDSFLVERGKLLHKRD 424
Query: 424 ESSKNIQQSNHLPKYERVKELCQQARYQTACEQPGQKWQCIEDTSGKLRIHKCKGPSDLL 483
+ Q+ N LPKY+RVK+LCQ+A YQTACEQ GQKWQC+ED +GKL++HKCKGP L
Sbjct: 425 NDKVDAQEENFLPKYQRVKDLCQRAEYQTACEQLGQKWQCVEDATGKLKLHKCKGPMRLG 484
Query: 484 TVRQSTRNLYARGFHDKDKECSCRESGYRASRSQRKSQRQFLRNQGTPKYKPRFVHTRQT 543
R + NL + + + C+C Y+ S + R+ ++ F + KYK +V +R
Sbjct: 485 GSR-ALSNLVPKYYGQGSEACTCDSGDYKLSLAGRR-KKLFKK-----KYKASYVRSRSI 537
Query: 544 RSLSVEFEGEIYDINLEEEEELQVLQPRNIAKRHDEGHKGPRDLQASSGGNRGRMLADSS 603
RS+++E +G +Y + L + QPRN+ KRH G P D GG D S
Sbjct: 538 RSVAIEVDGRVYHVGLGD-----AAQPRNLTKRHWPG--APEDQDDKDGG-------DFS 583
Query: 604 NAVGPP-----TTVRVTHKCFILPNDSIHCERELYQSARAWKDHKAYIDKEIEALQDKIK 658
G P ++VTH+C+IL ND++ C+ +LY+S +AWKDHK +ID EIE LQ+KIK
Sbjct: 584 GTGGLPDYSAANPIKVTHRCYILENDTVQCDLDLYKSLQAWKDHKLHIDHEIETLQNKIK 643
Query: 659 NLREVRGHLKRRKPEECSCSKQSYYNKEKGVKKQEKLKSHLHPFKEAAQEVDSKLQLFKE 718
NLREVRGHLK+++PEEC C K SY+ + KG K S LHPF++ QE D K+ L +E
Sbjct: 644 NLREVRGHLKKKRPEECDCHKISYHTQHKGRLKHR--GSSLHPFRKGLQEKD-KVWLLRE 700
Query: 719 NNRRRKKERKEKRRQRKGEECSLPGLTCFTHDNNHWQTAPFWNLGSFCACTSSNNNTYWC 778
+R+KK RK +R + + CS+PGLTCFTHDN HWQTAPFW LG FCACTS+NNNTYWC
Sbjct: 701 -QKRKKKLRKLLKRLQNNDTCSMPGLTCFTHDNQHWQTAPFWTLGPFCACTSANNNTYWC 759
Query: 779 LRTVNETHNFLFCEFATGFLEYFDMNTDPYQLTNTVHTVERGILNQLHVQLMELRSCQGY 838
+RT+NETHNFLFCEFATGFLEYFD+NTDPYQL N V+T++R +LNQLHVQLMELRSC+GY
Sbjct: 760 MRTINETHNFLFCEFATGFLEYFDLNTDPYQLMNAVNTLDRDVLNQLHVQLMELRSCKGY 819
Query: 839 KQCNPRPKNLDVGNKDGGSYDLHR------------------GQLWDGWEG 871
KQCNPR +N+D+G KDGGSY+ +R GQLW+GWEG
Sbjct: 820 KQCNPRTRNMDLGLKDGGSYEQYRQFQRRKWPEMKRPSSKSLGQLWEGWEG 870
>gi|240255478 sulfatase 2 isoform b precursor [Homo sapiens]
Length = 867
Score = 1206 bits (3120), Expect = 0.0
Identities = 577/891 (64%), Positives = 697/891 (78%), Gaps = 54/891 (6%)
Query: 7 ALVLAVLGT---ELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSLQVM 63
+LVL +L LLG + + R +GR Q++R+NIRPNIILVLTDDQDVELGS+QVM
Sbjct: 5 SLVLCLLSATVFSLLGGSSAFLSHHRLKGRFQRDRRNIRPNIILVLTDDQDVELGSMQVM 64
Query: 64 NKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAMHEP 123
NKTR+IME GGA FINAFVTTPMCCPSRSS+LTGKYVHNHN YTNNENCSSPSWQA HE
Sbjct: 65 NKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTGKYVHNHNTYTNNENCSSPSWQAQHES 124
Query: 124 RTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGWREWLGLIKNSRFYNYTVCRNGIKEKHG 183
RTFAVYLN+TGYRTAFFGKYLNEYNGSY+PPGW+EW+GL+KNSRFYNYT+CRNG+KEKHG
Sbjct: 125 RTFAVYLNSTGYRTAFFGKYLNEYNGSYVPPGWKEWVGLLKNSRFYNYTLCRNGVKEKHG 184
Query: 184 FDYAKDYFTDLITNESINYFKMSKRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPNASQ 243
DY+KDY TDLITN+S+++F+ SK+MYPHRPV+MVISHAAPHGPEDSAPQ+S+L+PNASQ
Sbjct: 185 SDYSKDYLTDLITNDSVSFFRTSKKMYPHRPVLMVISHAAPHGPEDSAPQYSRLFPNASQ 244
Query: 244 HITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNMLVET 303
HITPSYNYAPN DKHWIM+YTGPM PIHMEFTN+LQRKRLQTLMSVDDS+E +YNMLVET
Sbjct: 245 HITPSYNYAPNPDKHWIMRYTGPMKPIHMEFTNMLQRKRLQTLMSVDDSMETIYNMLVET 304
Query: 304 GELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSVEPGSIVPQIVLNID 363
GEL+NTYI+YTADHGYHIGQFGLVKGKSMPY+FDIRVPF++RGP+VE G + P IVLNID
Sbjct: 305 GELDNTYIVYTADHGYHIGQFGLVKGKSMPYEFDIRVPFYVRGPNVEAGCLNPHIVLNID 364
Query: 364 LAPTILDIAGLDTPPDVDGKSVLKLLDPEKPGNRFRTNKKAKIWRDTFLVERGKFLRKKE 423
LAPTILDIAGLD P D+DGKS+LKLLD E+P NRF KK ++WRD+FLVERGK L K++
Sbjct: 365 LAPTILDIAGLDIPADMDGKSILKLLDTERPVNRFHLKKKMRVWRDSFLVERGKLLHKRD 424
Query: 424 ESSKNIQQSNHLPKYERVKELCQQARYQTACEQPGQKWQCIEDTSGKLRIHKCKGPSDLL 483
+ Q+ N LPKY+RVK+LCQ+A YQTACEQ GQKWQC+ED +GKL++HKCKGP L
Sbjct: 425 NDKVDAQEENFLPKYQRVKDLCQRAEYQTACEQLGQKWQCVEDATGKLKLHKCKGPMRLG 484
Query: 484 TVRQSTRNLYARGFHDKDKECSCRESGYRASRSQRKSQRQFLRNQGTPKYKPRFVHTRQT 543
R + NL + + + C+C Y+ S + R+ ++ F + KYK +V +R
Sbjct: 485 GSR-ALSNLVPKYYGQGSEACTCDSGDYKLSLAGRR-KKLFKK-----KYKASYVRSRSI 537
Query: 544 RSLSVEFEGEIYDINLEEEEELQVLQPRNIAKRHDEGHKGPRDLQASSGGNRGRMLADSS 603
RS+++E +G +Y + L + QPRN+ KRH G P D GG D S
Sbjct: 538 RSVAIEVDGRVYHVGLGD-----AAQPRNLTKRHWPG--APEDQDDKDGG-------DFS 583
Query: 604 NAVGPP-----TTVRVTHKCFILPNDSIHCERELYQSARAWKDHKAYIDKEIEALQDKIK 658
G P ++VTH+C+IL ND++ C+ +LY+S +AWKDHK +ID EIE LQ+KIK
Sbjct: 584 GTGGLPDYSAANPIKVTHRCYILENDTVQCDLDLYKSLQAWKDHKLHIDHEIETLQNKIK 643
Query: 659 NLREVRGHLKRRKPEECSCSKQSYYNKEKGVKKQEKLKSHLHPFKEAAQEVDSKLQLFKE 718
NLREVRGHLK+++PEEC C K SY+ + KG K S LHPF++ QE D K+ L +E
Sbjct: 644 NLREVRGHLKKKRPEECDCHKISYHTQHKGRLKHR--GSSLHPFRKGLQEKD-KVWLLRE 700
Query: 719 NNRRRKKERKEKRRQRKGEECSLPGLTCFTHDNNHWQTAPFWNLGSFCACTSSNNNTYWC 778
+R+KK RK +R + + CS+PGLTCFTHDN HWQTAPFW LG FCACTS+NNNTYWC
Sbjct: 701 -QKRKKKLRKLLKRLQNNDTCSMPGLTCFTHDNQHWQTAPFWTLGPFCACTSANNNTYWC 759
Query: 779 LRTVNETHNFLFCEFATGFLEYFDMNTDPYQLTNTVHTVERGILNQLHVQLMELRSCQGY 838
+RT+NETHNFLFCEFATGFLEYFD+NTDPYQL N V+T++R +LNQLHVQLMELRSC+GY
Sbjct: 760 MRTINETHNFLFCEFATGFLEYFDLNTDPYQLMNAVNTLDRDVLNQLHVQLMELRSCKGY 819
Query: 839 KQCNPRPKNLDVGNKDGGSYDLHR------------------GQLWDGWEG 871
KQCNPR +N+D+ DGGSY+ +R GQLW+GWEG
Sbjct: 820 KQCNPRTRNMDL---DGGSYEQYRQFQRRKWPEMKRPSSKSLGQLWEGWEG 867
>gi|4504061 glucosamine (N-acetyl)-6-sulfatase precursor [Homo
sapiens]
Length = 552
Score = 312 bits (799), Expect = 1e-84
Identities = 164/359 (45%), Positives = 220/359 (61%), Gaps = 15/359 (4%)
Query: 42 RPNIILVLTDDQDVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVH 101
RPN++L+LTDDQD LG + + KT+ ++ G TF +A+V + +CCPSR+S+LTGKY H
Sbjct: 46 RPNVVLLLTDDQDEVLGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTGKYPH 105
Query: 102 NHNVYTNN--ENCSSPSWQAMHEPRTFAVYLNNT-GYRTAFFGKYLNEYNG------SYI 152
NH+V N NCSS SWQ + EP TF L + GY+T F GKYLNEY ++
Sbjct: 106 NHHVVNNTLEGNCSSKSWQKIQEPNTFPAILRSMCGYQTFFAGKYLNEYGAPDAGGLEHV 165
Query: 153 PPGWREWLGLIKNSRFYNYTVCRNGIKEKHGFDYAKDYFTDLITNESINYFKMSKRMYPH 212
P GW W L KNS++YNYT+ NG KHG +Y+ DY TD++ N S+++
Sbjct: 166 PLGWSYWYALEKNSKYYNYTLSINGKARKHGENYSVDYLTDVLANVSLDFLDYKSNF--- 222
Query: 213 RPVMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYNYAPNMDKHWIM-QYTGPMLPIH 271
P M+I+ APH P +APQ+ K + N ++N +KHW++ Q PM
Sbjct: 223 EPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPRNKNFNIH-GTNKHWLIRQAKTPMTNSS 281
Query: 272 MEFTNILQRKRLQTLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHIGQFGLVKGKS 331
++F + RKR QTL+SVDD VE+L L TGEL NTYI YT+D+GYH GQF L K
Sbjct: 282 IQFLDNAFRKRWQTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPIDKR 341
Query: 332 MPYDFDIRVPFFIRGPSVEPGSIVPQIVLNIDLAPTILDIAGLD-TPPDVDGKSVLKLL 389
Y+FDI+VP +RGP ++P +V NIDL PTILDIAG D +DG S+L +L
Sbjct: 342 QLYEFDIKVPLLVRGPGIKPNQTSKMLVANIDLGPTILDIAGYDLNKTQMDGMSLLPIL 400
Score = 63.9 bits (154), Expect = 6e-10
Identities = 28/74 (37%), Positives = 46/74 (62%), Gaps = 2/74 (2%)
Query: 766 CACTSSNNNTYWCLRTVNETHNFLFCEFATG--FLEYFDMNTDPYQLTNTVHTVERGILN 823
C C + NNTY C+RT++ N +CEF F+E +++ DP Q+TN T++ +L
Sbjct: 442 CVCEDAYNNTYACVRTMSALWNLQYCEFDDQEVFVEVYNLTADPDQITNIAKTIDPELLG 501
Query: 824 QLHVQLMELRSCQG 837
+++ +LM L+SC G
Sbjct: 502 KMNYRLMMLQSCSG 515
>gi|39930577 arylsulfatase K [Homo sapiens]
Length = 536
Score = 90.9 bits (224), Expect = 5e-18
Identities = 98/406 (24%), Positives = 180/406 (44%), Gaps = 49/406 (12%)
Query: 10 LAVLGTELLGSLCSTVRSPRFRGRIQQERKNIR-PNIILVLTDDQDVEL----GSLQVMN 64
+ +L ++ +L V +P G +Q R+ + PN++LV++D D L GS V
Sbjct: 1 MLLLWVSVVAALALAVLAP---GAGEQRRRAAKAPNVVLVVSDSFDGRLTFHPGSQVVKL 57
Query: 65 KTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAMHEPR 124
M+ G +F+NA+ +P+CCPSR++M +G + H + NN P++
Sbjct: 58 PFINFMKTRGTSFLNAYTNSPICCPSRAAMWSGLFTHLTESW-NNFKGLDPNY------T 110
Query: 125 TFAVYLNNTGYRTAFFGK--YLNEYN--GSYIPPGWREWLGLIKNSRFYNYTVCRNGIKE 180
T+ + GYRT FGK Y + ++ + + R+ L++ + RN K
Sbjct: 111 TWMDVMERHGYRTQKFGKLDYTSGHHSISNRVEAWTRDVAFLLRQEGRPMVNLIRNRTKV 170
Query: 181 KHGFDYAKDYFTDLITNESINYFKMSKRMYPHRPVMMVISHAAPHG-PEDSAPQ------ 233
+ +D+ T++++N+ + Y P ++ + PH P S+ +
Sbjct: 171 R---VMERDWQN---TDKAVNWLRKEAINYT-EPFVIYLGLNLPHPYPSPSSGENFGSST 223
Query: 234 -FSKLY--PNASQHITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMS-- 288
+ LY S ++P + H + Y+ FT +K ++ + +
Sbjct: 224 FHTSLYWLEKVSHDAIKIPKWSPLSEMHPVDYYSSYTKNCTGRFT----KKEIKNIRAFY 279
Query: 289 ------VDDSVERLYNMLVETGELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPF 342
D + + L + L+ T +IY++DHG + SM Y+ VP
Sbjct: 280 YAMCAETDAMLGEIILALHQLDLLQKTIVIYSSDHGELAMEHRQFYKMSM-YEASAHVPL 338
Query: 343 FIRGPSVEPGSIVPQIVLNIDLAPTILDIAGLDTPPDVDGKSVLKL 388
+ GP ++ G V +V +D+ PT+LDIAG+ P ++ G S+L L
Sbjct: 339 LMMGPGIKAGLQVSNVVSLVDIYPTMLDIAGIPLPQNLSGYSLLPL 384
>gi|4557659 iduronate-2-sulfatase isoform a precursor [Homo sapiens]
Length = 550
Score = 77.4 bits (189), Expect = 5e-14
Identities = 99/427 (23%), Positives = 155/427 (36%), Gaps = 82/427 (19%)
Query: 44 NIILVLTDDQDVELGSLQ---VMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYV 100
N++L++ DD LG V + + F NAF +C PSR S LTG+
Sbjct: 38 NVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRP 97
Query: 101 HNHNVYTNNENCSSPSWQAMHEPR--TFAVYLNNTGYRTAFFGKY----LNEYNGSYIPP 154
+Y N S+ +H T Y GY T GK ++ + P
Sbjct: 98 DTTRLYDFN------SYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPY 151
Query: 155 GWREWLGLIKNSRFYNYTVCRNGIKEKHG--------FDYAKDYFTDLITNESINYFKMS 206
W + ++ N CR E H D + D + E +
Sbjct: 152 SWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQL-LE 210
Query: 207 KRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYN---------YAPNMDK 257
K P + + + PH P +F KLYP + + P Y P MD
Sbjct: 211 KMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDI 270
Query: 258 HW-----IMQYTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNMLVETGELENTYII 312
+ + P PI ++F +++ ++ +D V RL + L + +T I
Sbjct: 271 RQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIA 330
Query: 313 YTADHGYHIGQFGLVKGKSMPYDFDIRVP--FFIRGPS---------------------- 348
+T+DHG+ +G+ G K +D VP F++ G +
Sbjct: 331 FTSDHGWALGEHG-EWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQ 389
Query: 349 -VEPGSIVPQIVLNIDLAPTILDIAGLDTPPDV-----------DGKSVLKLL------- 389
+EPG +V + L PT+ +AGL PP +GK++LK
Sbjct: 390 LMEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHVELCREGKNLLKHFRFRDLEE 449
Query: 390 DPEKPGN 396
DP PGN
Sbjct: 450 DPYLPGN 456
>gi|4503899 galactosamine (N-acetyl)-6-sulfate sulfatase precursor
[Homo sapiens]
Length = 522
Score = 67.8 bits (164), Expect = 4e-11
Identities = 92/374 (24%), Positives = 148/374 (39%), Gaps = 59/374 (15%)
Query: 43 PNIILVLTDDQDV-ELG-----SLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLT 96
PNI+L+L DD +LG S + N R E G F N + P+C PSR+++LT
Sbjct: 31 PNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAE--GLLFPNFYSANPLCSPSRAALLT 88
Query: 97 GKYVHNHNVYTNN---ENCSSPSWQAMHEP---RTFAVYLNNTGYRTAFFGKYLNEYNGS 150
G+ + YT N N +P P + L GY + GK+ +
Sbjct: 89 GRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRPQ 148
Query: 151 YIP--PGWREWLGLIKNSRFYNYTVCRNGIKEKHGFDYAKDYFTDLITNESINYFKMSKR 208
+ P G+ EW G N F Y K + +D+ +M R
Sbjct: 149 FHPLKHGFDEWFG-SPNCHFGPY-----DNKARPNIPVYRDW-------------EMVGR 189
Query: 209 MYPHRPVMMVISHAAPHGPEDSAPQFSKLY-PNASQHITPSYNYAPNMDKHWIMQYTGPM 267
Y P+ + A +++Y A I + P +W + T
Sbjct: 190 YYEEFPINLKTGEA----------NLTQIYLQEALDFIKRQARHHP-FFLYWAVDATHAP 238
Query: 268 LPIHMEFTNILQRKRL-QTLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHI----- 321
+ F QR R + +DDS+ ++ +L + +NT++ +T+D+G +
Sbjct: 239 VYASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPE 298
Query: 322 --GQFG-LVKGKSMPYDFDIRVPFFIRGPS-VEPGSIVPQIVLNIDLAPTILDIAGLDTP 377
G G + GK ++ +R P P V G + Q+ +DL T L +AGL P
Sbjct: 299 QGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPP 358
Query: 378 PD--VDGKSVLKLL 389
D +DG ++L L
Sbjct: 359 SDRAIDGLNLLPTL 372
>gi|109389362 arylsulfatase J [Homo sapiens]
Length = 599
Score = 64.3 bits (155), Expect = 5e-10
Identities = 79/366 (21%), Positives = 146/366 (39%), Gaps = 59/366 (16%)
Query: 42 RPNIILVLTDDQ---DVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGK 98
+P++I +L DDQ DV ++ T + G N +V P+C PSRS +TGK
Sbjct: 75 QPHLIFILADDQGFRDVGYHGSEIKTPTLDKLAAEGVKLENYYVQ-PICTPSRSQFITGK 133
Query: 99 YVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKY-LNEYNGSYIPP--G 155
Y + + + + P+ + + T L GY T GK+ L Y +P G
Sbjct: 134 YQIHTGLQHSIIRPTQPNCLPL-DNATLPQKLKEVGYSTHMVGKWHLGFYRKECMPTRRG 192
Query: 156 WREWLG-LIKNSRFYNYTVCRN-GI-------KEKHGFDYAKDYFTDLITNESINYFKMS 206
+ + G L+ + +Y + C + G+ + +DY ++ + + + S
Sbjct: 193 FDTFFGSLLGSGDYYTHYKCDSPGMCGYDLYENDNAAWDYDNGIYSTQMYTQRVQQILAS 252
Query: 207 KRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYNYAPNMDKHWIMQYTGP 266
P +P+ + I++ A H P +Q G
Sbjct: 253 HN--PTKPIFLYIAYQAVHSP---------------------------------LQAPGR 277
Query: 267 MLPIHMEFTNILQRKRLQTLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHIGQFG- 325
+ NI +R+ L +D+++ + L G N+ IIY++D+G G
Sbjct: 278 YFEHYRSIININRRRYAAMLSCLDEAINNVTLALKTYGFYNNSIIIYSSDNGGQPTAGGS 337
Query: 326 ---LVKGKSMPYDFDIRVPFFIRGPSVE-PGSIVPQIVLNIDLAPTILDIA--GLDTPPD 379
L K ++ IR F+ P ++ G++ ++V D PT++ +A +D
Sbjct: 338 NWPLRGSKGTYWEGGIRAVGFVHSPLLKNKGTVCKELVHITDWYPTLISLAEGQIDEDIQ 397
Query: 380 VDGKSV 385
+DG +
Sbjct: 398 LDGYDI 403
>gi|59797060 arylsulfatase family, member I [Homo sapiens]
Length = 569
Score = 61.2 bits (147), Expect = 4e-09
Identities = 87/351 (24%), Positives = 145/351 (41%), Gaps = 58/351 (16%)
Query: 43 PNIILVLTDDQ---DVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKY 99
P+II +LTDDQ DV + T + G N ++ P+C PSRS +LTG+Y
Sbjct: 47 PHIIFILTDDQGYHDVGYHGSDIETPTLDRLAAKGVKLENYYIQ-PICTPSRSQLLTGRY 105
Query: 100 -VH---NHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGK-YLNEYNGSYIPP 154
+H H++ + P Q T L GY T GK +L Y +P
Sbjct: 106 QIHTGLQHSIIRPQQPNCLPLDQV-----TLPQKLQEAGYSTHMVGKWHLGFYRKECLPT 160
Query: 155 --GWREWLG-LIKNSRFYNYTVCRN-GIKEKHGFDYAKDYFTDLITNESINY---FKMSK 207
G+ +LG L N +Y Y C G+ GF DL E++ + + S
Sbjct: 161 RRGFDTFLGSLTGNVDYYTYDNCDGPGV---CGF--------DLHEGENVAWGLSGQYST 209
Query: 208 RMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYNYAPNMDKHWIMQYTGPM 267
+Y R ++ SH +PQ P + Y H +Q
Sbjct: 210 MLYAQRASHILASH---------SPQ------------RPLFLYVAFQAVHTPLQSPREY 248
Query: 268 LPIHMEFTNILQRKRLQTLMSVDDSVERLYNMLVETGELENTYIIYTADHG---YHIGQF 324
L + N+ +RK + +D++V + L G N+ II+++D+G + G
Sbjct: 249 LYRYRTMGNVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQTFSGGSN 308
Query: 325 GLVKGKSMPY-DFDIRVPFFIRGPSVEPGSIVPQIVLNI-DLAPTILDIAG 373
++G+ Y + +R F+ P ++ + +++I D PT++ +AG
Sbjct: 309 WPLRGRKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAG 359
>gi|5360208 iduronate-2-sulfatase isoform b precursor [Homo sapiens]
Length = 343
Score = 60.8 bits (146), Expect = 5e-09
Identities = 70/307 (22%), Positives = 112/307 (36%), Gaps = 38/307 (12%)
Query: 44 NIILVLTDDQDVELGSLQ---VMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYV 100
N++L++ DD LG V + + F NAF +C PSR S LTG+
Sbjct: 38 NVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRP 97
Query: 101 HNHNVYTNNENCSSPSWQAMHEPR--TFAVYLNNTGYRTAFFGKY----LNEYNGSYIPP 154
+Y N S+ +H T Y GY T GK ++ + P
Sbjct: 98 DTTRLYDFN------SYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPY 151
Query: 155 GWREWLGLIKNSRFYNYTVCRNGIKEKHG--------FDYAKDYFTDLITNESINYFKMS 206
W + ++ N CR E H D + D + E +
Sbjct: 152 SWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQL-LE 210
Query: 207 KRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYN---------YAPNMDK 257
K P + + + PH P +F KLYP + + P Y P MD
Sbjct: 211 KMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDI 270
Query: 258 HW-----IMQYTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNMLVETGELENTYII 312
+ + P PI ++F +++ ++ +D V RL + L + +T I
Sbjct: 271 RQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIA 330
Query: 313 YTADHGY 319
+T+DHG+
Sbjct: 331 FTSDHGF 337
>gi|4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo
sapiens]
Length = 502
Score = 56.6 bits (135), Expect = 1e-07
Identities = 92/412 (22%), Positives = 152/412 (36%), Gaps = 86/412 (20%)
Query: 4 SCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSLQ-- 61
+CCAL+L VLG LC R R R N +L+L DD E G+
Sbjct: 7 ACCALLL-VLG------LC------RARPR----------NALLLLADDGGFESGAYNNS 43
Query: 62 -VMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAM 120
+ + F NAF + C PSR+S+LTG H + +Y +++ + +
Sbjct: 44 AIATPHLDALARRSLLFRNAFTSVSSCSPSRASLLTGLPQHQNGMYGLHQDVH--HFNSF 101
Query: 121 HEPRTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGWREWLGLIKNSRFYNYTVCRNGIKE 180
+ R+ + L+ G RT GK ++ P Y +
Sbjct: 102 DKVRSLPLLLSQAGVRTGIIGK-------KHVGP-----------ETVYPF--------- 134
Query: 181 KHGFDYAKDYFTDLITNESINYFKMSKRMY----PHRPVMMVISHAAPHGPEDSAPQ--- 233
F Y ++ + L +I K+ R + RP + ++ PH S PQ
Sbjct: 135 --DFAYTEENGSVLQVGRNITRIKLLVRKFLQTQDDRPFFLYVAFHDPHRCGHSQPQYGT 192
Query: 234 FSKLYPNASQHITPSYNYAPNM--DKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMSVDD 291
F + + N + ++ P ++ Y P P + T+ +D
Sbjct: 193 FCEKFGNGESGMGRIPDWTPQAYDPLDVLVPYFVPNTPA----ARADLAAQYTTVGRMDQ 248
Query: 292 SVERLYNMLVETGELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSVEP 351
V + L + G L +T +I+T+D+G G++ Y P + P
Sbjct: 249 GVGLVLQELRDAGVLNDTLVIFTSDNG-----IPFPSGRTNLYWPGTAEPLLVSSPEHPK 303
Query: 352 --GSIVPQIVLNIDLAPTILDIAGLDTPP---------DVDGKSVLKLLDPE 392
G + V +DL PTILD + P + G+S+L L+ E
Sbjct: 304 RWGQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPALEAE 355
>gi|53831991 steryl-sulfatase precursor [Homo sapiens]
Length = 583
Score = 55.1 bits (131), Expect = 3e-07
Identities = 37/117 (31%), Positives = 62/117 (52%), Gaps = 15/117 (12%)
Query: 289 VDDSVERLYNMLVETGELENTYIIYTADHGYHI-----------GQFGLVK-GKSMPYDF 336
+D SV ++ N+L E +T I +T+D G H+ G G+ K GK+ ++
Sbjct: 315 MDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEG 374
Query: 337 DIRVPFFIRGPSV-EPGSIVPQIVLNIDLAPTILDIAGLDTPPD--VDGKSVLKLLD 390
IRVP +R P V + G + + N+D+ PT+ +AG P D +DG+ ++ LL+
Sbjct: 375 GIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLE 431
Score = 47.8 bits (112), Expect = 5e-05
Identities = 31/110 (28%), Positives = 50/110 (45%), Gaps = 8/110 (7%)
Query: 42 RPNIILVLTDDQDVE----LGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTG 97
RPNIILV+ DD + G+ + + GG +P+C PSR++ +TG
Sbjct: 26 RPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTG 85
Query: 98 KYVHNHNVYTNNEN----CSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKY 143
+Y + + + ++ S + TFA L + GY TA GK+
Sbjct: 86 RYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKW 135
>gi|38569407 arylsulfatase B isoform 2 precursor [Homo sapiens]
Length = 413
Score = 55.1 bits (131), Expect = 3e-07
Identities = 85/386 (22%), Positives = 149/386 (38%), Gaps = 73/386 (18%)
Query: 43 PNIILVLTDD---QDVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKY 99
P+++ +L DD DV ++ + GG N + T P+C PSRS +LTG+Y
Sbjct: 45 PHLVFLLADDLGWNDVGFHGSRIRTPHLDALAAGGVLLDN-YYTQPLCTPSRSQLLTGRY 103
Query: 100 VHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKY-LNEYNGSYIPP--GW 156
+ PS + E + L GY T GK+ L Y +P G+
Sbjct: 104 QIRTGLQHQIIWPCQPSCVPLDE-KLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGF 162
Query: 157 REWLGLIKNSRFY------------NYTVCRNGIK--EKHGFDYAKDYFTDLITNESINY 202
+ G + S Y N T C + E+ Y Y T++ T +I
Sbjct: 163 DTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAI-- 220
Query: 203 FKMSKRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYNYAPNMDKHWIMQ 262
+ P +P+ + ++ + H P ++ K Y++ + ++H
Sbjct: 221 -ALITNHPPEKPLFLYLALQSVHEPLQVPEEYLK-----------PYDFIQDKNRH---H 265
Query: 263 YTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHIG 322
Y G + +LM D++V + L +G NT I++ D+G G
Sbjct: 266 YAG-----------------MVSLM--DEAVGNVTAALKSSGLWNNTVFIFSTDNG---G 303
Query: 323 QFGLVKGKSMP--------YDFDIRVPFFIRGPSVEPGSIVPQIVLNI-DLAPTILDIAG 373
Q L G + P ++ +R F+ P ++ + + +++I D PT++ +A
Sbjct: 304 Q-TLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLAR 362
Query: 374 LDT--PPDVDGKSVLKLLDPEKPGNR 397
T +DG V K + P R
Sbjct: 363 GHTNGTKPLDGFDVWKTISEGSPSPR 388
>gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens]
Length = 533
Score = 55.1 bits (131), Expect = 3e-07
Identities = 85/386 (22%), Positives = 149/386 (38%), Gaps = 73/386 (18%)
Query: 43 PNIILVLTDD---QDVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKY 99
P+++ +L DD DV ++ + GG N + T P+C PSRS +LTG+Y
Sbjct: 45 PHLVFLLADDLGWNDVGFHGSRIRTPHLDALAAGGVLLDN-YYTQPLCTPSRSQLLTGRY 103
Query: 100 VHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKY-LNEYNGSYIPP--GW 156
+ PS + E + L GY T GK+ L Y +P G+
Sbjct: 104 QIRTGLQHQIIWPCQPSCVPLDE-KLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGF 162
Query: 157 REWLGLIKNSRFY------------NYTVCRNGIK--EKHGFDYAKDYFTDLITNESINY 202
+ G + S Y N T C + E+ Y Y T++ T +I
Sbjct: 163 DTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAI-- 220
Query: 203 FKMSKRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYNYAPNMDKHWIMQ 262
+ P +P+ + ++ + H P ++ K Y++ + ++H
Sbjct: 221 -ALITNHPPEKPLFLYLALQSVHEPLQVPEEYLK-----------PYDFIQDKNRH---H 265
Query: 263 YTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHIG 322
Y G + +LM D++V + L +G NT I++ D+G G
Sbjct: 266 YAG-----------------MVSLM--DEAVGNVTAALKSSGLWNNTVFIFSTDNG---G 303
Query: 323 QFGLVKGKSMP--------YDFDIRVPFFIRGPSVEPGSIVPQIVLNI-DLAPTILDIAG 373
Q L G + P ++ +R F+ P ++ + + +++I D PT++ +A
Sbjct: 304 Q-TLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLAR 362
Query: 374 LDT--PPDVDGKSVLKLLDPEKPGNR 397
T +DG V K + P R
Sbjct: 363 GHTNGTKPLDGFDVWKTISEGSPSPR 388
>gi|31742482 arylsulfatase F precursor [Homo sapiens]
Length = 590
Score = 50.1 bits (118), Expect = 9e-06
Identities = 34/116 (29%), Positives = 60/116 (51%), Gaps = 15/116 (12%)
Query: 289 VDDSVERLYNMLVETGELENTYIIYTADHGYHI----------GQFGLVK-GKSM-PYDF 336
+D V ++ + + + G NT + +T+DHG H+ G G+ K GK M ++
Sbjct: 318 MDSMVGKILDAIDDFGLRNNTLVYFTSDHGGHLEARRGHAQLGGWNGIYKGGKGMGGWEG 377
Query: 337 DIRVPFFIRGPSVEP-GSIVPQIVLNIDLAPTILDIAGLDTPPD--VDGKSVLKLL 389
IRVP +R P P G ++ + +D+ PT+ ++G P D +DG+ ++ LL
Sbjct: 378 GIRVPGIVRWPGKVPAGRLIKEPTSLMDILPTVASVSGGSLPQDRVIDGRDLMPLL 433
Score = 43.1 bits (100), Expect = 0.001
Identities = 33/113 (29%), Positives = 53/113 (46%), Gaps = 14/113 (12%)
Query: 42 RPNIILVLTDDQDV-ELGSLQVMNKTRKI-----MEHGGATFINAFVTTPMCCPSRSSML 95
+PNI+L++ DD + +LG N T + + G +C PSRS+ L
Sbjct: 29 KPNIVLIMVDDLGIGDLGCYG--NDTMRTPHIDRLAREGVRLTQHISAASLCSPSRSAFL 86
Query: 96 TGKY-VHNHNVYTNN----ENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKY 143
TG+Y + + V + N +N + P+ ++E T A L GY T GK+
Sbjct: 87 TGRYPIRSGMVSSGNRRVIQNLAVPAGLPLNE-TTLAALLKKQGYSTGLIGKW 138
>gi|71852584 arylsulfatase D isoform a precursor [Homo sapiens]
Length = 593
Score = 47.8 bits (112), Expect = 5e-05
Identities = 34/116 (29%), Positives = 60/116 (51%), Gaps = 15/116 (12%)
Query: 289 VDDSVERLYNMLVETGELENTYIIYTADHGYHI----------GQFGLVK-GKSM-PYDF 336
+D + ++ N + + G +T+ +T+DHG H+ G G+ K GK M ++
Sbjct: 329 MDWLIGKVLNAIEDNGLKNSTFTYFTSDHGGHLEARDGHSQLGGWNGIYKGGKGMGGWEG 388
Query: 337 DIRVPFFIRGPSVEP-GSIVPQIVLNIDLAPTILDIAGLDTPPD--VDGKSVLKLL 389
IRVP P V P G ++ + +D+ PT++ + G + P D +DG S++ LL
Sbjct: 389 GIRVPGIFHWPGVLPAGRVIGEPTSLMDVFPTVVQLVGGEVPQDRVIDGHSLVPLL 444
Score = 41.2 bits (95), Expect = 0.004
Identities = 32/113 (28%), Positives = 49/113 (43%), Gaps = 14/113 (12%)
Query: 42 RPNIILVLTDDQDV-ELG-----SLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSML 95
+PNI+L++ DD +LG +L+ N + E G P+C PSR++ L
Sbjct: 40 KPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEE--GVRLTQHLAAAPLCTPSRAAFL 97
Query: 96 TGKYVHNHNVYTNNENCSSPSWQA-----MHEPRTFAVYLNNTGYRTAFFGKY 143
TG++ + +N + W A TFA L GY T GK+
Sbjct: 98 TGRHSFRSGMDASN-GYRALQWNAGSGGLPENETTFARILQQHGYATGLIGKW 149
>gi|45430057 Arylsulfatase G [Homo sapiens]
Length = 525
Score = 47.8 bits (112), Expect = 5e-05
Identities = 38/124 (30%), Positives = 59/124 (47%), Gaps = 6/124 (4%)
Query: 34 IQQERKNIRPNIILVLTDDQDV-ELGSLQVMNK-TRKI--MEHGGATFINAFVTTPMCCP 89
I + + +PN +++L DD +LG+ K T + M G F++ C P
Sbjct: 27 ISGKTRGQKPNFVIILADDMGWGDLGANWAETKDTANLDKMASEGMRFVDFHAAASTCSP 86
Query: 90 SRSSMLTGKYVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKYLNEYNG 149
SR+S+LTG+ + N T N +S ++E T A L GY T GK+ ++G
Sbjct: 87 SRASLLTGR-LGLRNGVTRNFAVTSVGGLPLNE-TTLAEVLQQAGYVTGIIGKWHLGHHG 144
Query: 150 SYIP 153
SY P
Sbjct: 145 SYHP 148
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 47.4 bits (111), Expect = 6e-05
Identities = 74/381 (19%), Positives = 152/381 (39%), Gaps = 58/381 (15%)
Query: 392 EKPGNRFRTNKKAKIWRDTFLVERGKFLRKKEESSKNIQQSNHLPKYERVKELCQQARYQ 451
E+P R R + + + L + + L ++E+ + ++ + E ++ ++ RY+
Sbjct: 1156 EEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYR 1215
Query: 452 TACEQPGQKWQCIEDTSGKLRIHK--CKG---------PSDLLTVRQSTRNL-------- 492
++ KWQ + +R +K CKG L RQS ++L
Sbjct: 1216 DEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQ 1275
Query: 493 -----------YARGFHDKDKECSCRESGYRASRSQRKSQ--RQFLRNQGTPKYKPRFVH 539
R H ++E RE A R RKSQ +Q LR + K
Sbjct: 1276 ERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEK------- 1328
Query: 540 TRQTRSLSVEFEGEIYDINLEEEEELQVLQPRNIAKRHDEGHKGPRDLQASSGGNRGRML 599
R+ + +F EEE+ LQ + + + ++ + +L+ +GR
Sbjct: 1329 -RRRQETDRKFR--------EEEQLLQEREEQPLRRQERDRKFREEELRHQ---EQGRKF 1376
Query: 600 ADSSNAVGPPTTVRVTHKCFILPNDSIHCERELYQSARAWKDHKAYIDKEIEALQDKIKN 659
+ + R F+ + C+ E Q R +D K +++ + Q++ +
Sbjct: 1377 LEEEQRLRRQERERK----FLKEEQQLRCQ-EREQQLRQDRDRKFREEEQQLSRQERDRK 1431
Query: 660 LREVRGHLKRRKPEECSCSKQSYYNKEKGVK--KQEKLKSHLHPFKEAAQEVDSKLQLFK 717
RE ++R++ E ++ +E+ K ++E+L + QE D K +
Sbjct: 1432 FREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEE 1491
Query: 718 ENNRRRKKERKEKRRQRKGEE 738
+ RR++++RK + ++ + +E
Sbjct: 1492 QQLRRQERDRKFREQELRSQE 1512
Score = 44.7 bits (104), Expect = 4e-04
Identities = 70/352 (19%), Positives = 142/352 (40%), Gaps = 31/352 (8%)
Query: 415 RGKFLRKKEESSKNIQQSNHLPKYERVKELCQQAR----YQTACEQPGQKWQCIEDTSGK 470
R + L ++E+ + + +PK++ E AR Y +Q GQ+ + ++ +
Sbjct: 681 REQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRR 740
Query: 471 LRIHKCKGPSDLLTVRQSTRNLYARGF------HDKDKECSCRESGYRASRSQRKSQ-RQ 523
R + + + RQ R F +K + R S R QR+ Q R
Sbjct: 741 RRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRA 800
Query: 524 FLRNQGTPKYKPRFVHTRQTRSLSVEFEGEIYDINLEEEEELQVLQPRNIAKRHDEGHKG 583
R Q ++ P Q R E E E+ LEEEE+LQ + + ++G +
Sbjct: 801 EERQQREQRFLPEEEEKEQRRRQRREREKELQF--LEEEEQLQRRERAQQLQEEEDGLQE 858
Query: 584 PRDLQASSGGNRG----------RMLADSSNAVGPPTTVRVTHKCFILPNDSIHCERELY 633
++ + S R R + P ++ + +L + +RE
Sbjct: 859 DQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREER 918
Query: 634 QSARAWKDHKAYIDKEIEALQDKIKNLREVRGHLKR-------RKPEECSCSKQSYYNKE 686
+ R + + Y ++E + Q++ + LRE R +R RK ++ ++ +E
Sbjct: 919 EKRRRQEQERQYREEE-QLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEE 977
Query: 687 KGVKKQEKLKSHLHPFKEAAQEVDSKLQLFKENNRRRKKERKEKRRQRKGEE 738
+++++ + +E QE + L+ +E RR++ ER+ +++ +E
Sbjct: 978 PEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQE 1029
Score = 40.4 bits (93), Expect = 0.007
Identities = 58/341 (17%), Positives = 145/341 (42%), Gaps = 45/341 (13%)
Query: 413 VERGKFLRKKEESSKNIQQSNHLPKYERVKELCQQA--RYQTACEQPGQKWQCIEDTSGK 470
+E + LR++E K +++ L ER ++L Q +++ +Q ++ + + +
Sbjct: 1377 LEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEE 1436
Query: 471 LRIHKCKGPSDLLTVRQSTRNLYARGFHDKDKECSCRESG--YRASRSQR--KSQRQFLR 526
++ + + L Q R R F ++++ RE +R R ++ + ++Q R
Sbjct: 1437 QQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRR 1496
Query: 527 NQGTPKYKPRFVHTRQTRSLSVEFEGEIYDINLEEEEELQVLQPRNIAKRHDEGHKGPRD 586
+ K++ + + +++ +E E +++ ++ + + LQ +R + G + +D
Sbjct: 1497 QERDRKFREQELRSQEPERKFLEEEQQLH----RQQRQRKFLQEEQQLRRQERGQQRRQD 1552
Query: 587 LQASSGGNRGRMLADSSNAVGPPTTVRVTHKCFILPNDSIHCERELYQSARAWKDHKAYI 646
R R + + + ERE Q +R +D K +
Sbjct: 1553 --------RDRKFREE---------------------EQLRQEREEQQLSRQERDRKFRL 1583
Query: 647 DKEIEALQDKIKNLREVRGHLKRRKPEECSCSKQSYYNKEKGVKKQEKLKSHLHPFKEAA 706
+++ Q++ + E L+R++ ++ ++ +E QE+ + LH +
Sbjct: 1584 EEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDR 1643
Query: 707 QEVDSKLQLFKENNR------RRKKERKEKRRQRKGEECSL 741
+ ++ + QL ++ R +K R+E++ ++GEE L
Sbjct: 1644 KFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQL 1684
Score = 39.7 bits (91), Expect = 0.012
Identities = 67/329 (20%), Positives = 136/329 (41%), Gaps = 15/329 (4%)
Query: 415 RGKFLRKKEESSKNIQQSNHLPKYERVKELCQQARYQTACEQPGQKWQCIEDTSGKLRIH 474
R + LR+++E + QQ + ER ++ ++ + Q EQ ++ Q + R
Sbjct: 347 REQQLRREQEEERREQQLRREQEEERREQQLRREQ-QLRREQQLRREQQLRREQQLRREQ 405
Query: 475 KCKGPSDLLTVRQSTRNLYARGFHDKDKECSCRESGYRASRSQRKSQ--RQFLRNQGTPK 532
+ + L +Q R R ++++ E R R +R+ + R +L+ + +
Sbjct: 406 QLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETE 465
Query: 533 YKPRFVHTRQTRSLSVEFEGEIYD--INLEEEEELQVLQPRNIAKRHDEGHKGPRDLQAS 590
R R+ + L + E E + + LEEEE + + R R ++ + + L+
Sbjct: 466 ---RHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQ 522
Query: 591 SGGNRGRMLADSSNAVGPPTTVRVTHKCFILPNDSIHCERELYQSARAWKDHK-AYIDKE 649
R + S + R + ER + R ++ + + +E
Sbjct: 523 EEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKRE 582
Query: 650 IEALQDKIKNLREVRGHLKRRKPEECSCSKQSYYNKEKGVKKQEKLKSHLHPFKEAAQEV 709
E Q ++K +E R +R K EE +Q +++ +++ + + K QE
Sbjct: 583 EERRQQRLKREQEERLE-QRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEE 641
Query: 710 DSKLQLFKENNRRRKKERKEKRRQRKGEE 738
+ QL RR ++ER+E+R +R+ EE
Sbjct: 642 RRQQQL-----RREQQERREQRLKREEEE 665
Score = 35.0 bits (79), Expect = 0.30
Identities = 53/248 (21%), Positives = 102/248 (41%), Gaps = 32/248 (12%)
Query: 507 RESGYRASRSQRKSQRQFLRNQGTPKYKPRFVHTRQTRSLSVEFEGEIYDINLEEEEELQ 566
RE YR ++ + Q LR + + + + + + + E ++ L EE E +
Sbjct: 986 REKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQL----LREEREKR 1041
Query: 567 VLQPRNIAKRHDEGHKGPRDLQASSGGNRGRMLADSSNAVGPPTTVRVTHKCFILPNDSI 626
LQ R R +E +LQ ++L + R K L +
Sbjct: 1042 RLQERERQYREEE------ELQQEEE----QLLGEERETRRRQELERQYRKEEELQQEEE 1091
Query: 627 HCERELYQSARAWKDHKAYIDKEIEALQDKIKNLREVRGHLKR-------RKPEECSCSK 679
RE + R ++ + +E E Q++ + LRE R +R R+ EE +
Sbjct: 1092 QLLREEPEKRRR-QERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEE 1150
Query: 680 QSYYNKEKGVKKQEKLKSHLHPFKEAAQEVDSKLQLFKENNRRRKKER---------KEK 730
+ +E +++++L+ +E QE + L+ +E RR+++ER ++K
Sbjct: 1151 EQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEK-RRQERERQYREEEELQRQK 1209
Query: 731 RRQRKGEE 738
R+QR +E
Sbjct: 1210 RKQRYRDE 1217
Score = 34.7 bits (78), Expect = 0.39
Identities = 53/279 (18%), Positives = 107/279 (38%), Gaps = 39/279 (13%)
Query: 475 KCKGPSDLLTVRQSTRNLYARGFHDKDKECSCRESGYRASRSQRKSQRQFLRNQGTPKYK 534
+C G LL R+ + R F +D++ E G R + +++ +R+ + + +
Sbjct: 102 RCDGKESLLQDRRQEED--QRRFEPRDRQLE-EEPGQRRRQKRQEQERELAEGEEQSEKQ 158
Query: 535 PRFVHT-RQTRSLSVEFEGEIYDINLE---EEEELQVLQPRNIAKRHDEGHKGPRDLQAS 590
R RQ R + + + + E EEE+LQ + + DE R+L
Sbjct: 159 ERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLEL 218
Query: 591 SGGNRGRMLADSSNAVGPPTTVRVTHKCFILPNDSIHCERELYQSARAWKDHKAYIDKEI 650
R D + E E + W+ + + KE
Sbjct: 219 RRKGREEKQQQRRER-----------------QDRVFQEEE----EKEWRKRETVLRKEE 257
Query: 651 EALQDKI-----------KNLREVRGHLKRRKPEECSCSKQSYYNKEKGVKKQEKLKSHL 699
E LQ++ + LR++ RR+ +E +Q +++ +KQE+ +
Sbjct: 258 EKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQ 317
Query: 700 HPFKEAAQEVDSKLQLFKENNRRRKKERKEKRRQRKGEE 738
+ QE + + +E RR++E + +++ R+ +E
Sbjct: 318 QEERREQQERREQQEERREQQLRREQEERREQQLRREQE 356
Score = 33.5 bits (75), Expect = 0.88
Identities = 52/242 (21%), Positives = 99/242 (40%), Gaps = 16/242 (6%)
Query: 508 ESGYRASRSQRKSQRQFLRNQG----TPKYKPRFVHTRQTRSLSVEFEGEIYDINLEEEE 563
E G + + +R+SQ Q R+Q + + R HT + E + + EEEE
Sbjct: 853 EDGLQEDQERRRSQEQ-RRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEE 911
Query: 564 ELQVLQPRNIAKRHDEGHKGPRDLQASSGGNRGRMLADSSNAVGPPTTVRVTHKCFILPN 623
ELQ + R +R ++ + + Q ++L + R K L
Sbjct: 912 ELQ-REEREKRRRQEQERQYREEEQLQQ--EEEQLLREEREKRRRQERERQYRKDKKLQQ 968
Query: 624 DSIHCERELYQSARAWKDHKAYIDKEIEALQDKIKNLREVRGHLKR-------RKPEECS 676
E + R + K Y ++E E Q++ + LRE R +R RK +E
Sbjct: 969 KEEQLLGEEPEKRRRQEREKKYREEE-ELQQEEEQLLREEREKRRRQEWERQYRKKDELQ 1027
Query: 677 CSKQSYYNKEKGVKKQEKLKSHLHPFKEAAQEVDSKLQLFKENNRRRKKERKEKRRQRKG 736
++ +E+ ++ ++ + +E QE + L +E RR++ ER+ ++ +
Sbjct: 1028 QEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQ 1087
Query: 737 EE 738
+E
Sbjct: 1088 QE 1089
Score = 33.5 bits (75), Expect = 0.88
Identities = 71/348 (20%), Positives = 131/348 (37%), Gaps = 38/348 (10%)
Query: 399 RTNKKAKIWRDTFLVERGKFLRKKEESSKNIQQSNHLPKYERVKELCQQARYQTACEQPG 458
R + K + V R + RK E + ++Q H K+ ++L Q+ Q Q
Sbjct: 1425 RQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHR-KFREEEQLLQEREEQQLHRQE- 1482
Query: 459 QKWQCIEDTSGKLRIHKCKGPSDLLTVRQSTRNLYARGFHDKDKECSCRESGYRASRSQR 518
R K L ++ R + ++ E E + R QR
Sbjct: 1483 -------------RDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQR 1529
Query: 519 KSQRQFLRNQGTPKYKPRFVHTRQTRSLSVEFEGEIYDINLEEEEELQVLQPRNIAKRHD 578
QR+FL+ + + + R RQ R E ++ +E EE Q+ + K
Sbjct: 1530 --QRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLR----QEREEQQLSRQERDRKFRL 1583
Query: 579 EGHKGPRDLQASSGGNRGRMLADSSNAVGPPTTVRVTHKCFILPNDSIHCERELYQSARA 638
E K R Q + L +R ++ + ERE Q R
Sbjct: 1584 EEQKVRRQEQERKFMEDEQQLRRQEGQ----QQLRQERDRKFREDEQLLQEREEQQLHRQ 1639
Query: 639 WKDHKAYIDKEIEALQDKIKNLREVRGHLKR------RKPEECSCSKQ----SYYNKEKG 688
+D K ++ Q++ + LR R R ++ EE +Q + +E+
Sbjct: 1640 ERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQ 1699
Query: 689 VKKQEKLKSHLHPFKE-AAQEVDSKLQLFKENNRRRKKERKEKRRQRK 735
+++QE+ + L ++ QE++ K + +E R++ E+++ RRQ +
Sbjct: 1700 LRRQERERKFLQEEQQLRRQELERKFR--EEEQLRQETEQEQLRRQER 1745
Score = 31.2 bits (69), Expect = 4.4
Identities = 25/118 (21%), Positives = 56/118 (47%), Gaps = 5/118 (4%)
Query: 629 ERELYQSARAWKDHKAYIDKEI---EALQDKIKNLREVRGHLKRRKPEECSCSKQSYYNK 685
E E QS + + + ++++ E L+ + K E + + R+ ++ + K
Sbjct: 189 EEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRK 248
Query: 686 EKGV--KKQEKLKSHLHPFKEAAQEVDSKLQLFKENNRRRKKERKEKRRQRKGEECSL 741
+ V K++EKL+ + QE + +L+ + RR+++ +E+++QR E L
Sbjct: 249 RETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQL 306
>gi|58743319 arylsulfatase family, member H [Homo sapiens]
Length = 562
Score = 47.0 bits (110), Expect = 8e-05
Identities = 35/114 (30%), Positives = 49/114 (42%), Gaps = 9/114 (7%)
Query: 39 KNIRPNIILVLTDDQDVE----LGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSM 94
+N RPNI+L++ DD V G+ V + G MC PSR++
Sbjct: 3 RNARPNIVLLMADDLGVGDLCCYGNNSVSTPNIDRLASEGVRLTQHLAAASMCTPSRAAF 62
Query: 95 LTGKY-VHNHNVYTNNENCS----SPSWQAMHEPRTFAVYLNNTGYRTAFFGKY 143
LTG+Y + + V N N + S TFA L + GYRT GK+
Sbjct: 63 LTGRYPIRSGMVSAYNLNRAFTWLGGSGGLPTNETTFAKLLQHRGYRTGLIGKW 116
>gi|157266309 arylsulfatase E precursor [Homo sapiens]
Length = 589
Score = 46.6 bits (109), Expect = 1e-04
Identities = 38/116 (32%), Positives = 60/116 (51%), Gaps = 15/116 (12%)
Query: 289 VDDSVERLYNMLVETGELENTYIIYTADHGYHI----------GQFGLVK-GKSM-PYDF 336
+D V R+ + L G +T I +T+DHG + G G+ K GK M ++
Sbjct: 326 MDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNGIYKGGKGMGGWEG 385
Query: 337 DIRVPFFIRGPSVEP-GSIVPQIVLNIDLAPTILDIAGLDTPPD--VDGKSVLKLL 389
IRVP R P V P G ++ + +D+ PT++ +AG + P D +DG+ +L LL
Sbjct: 386 GIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLLPLL 441
Score = 37.0 bits (84), Expect = 0.080
Identities = 29/112 (25%), Positives = 48/112 (42%), Gaps = 12/112 (10%)
Query: 42 RPNIILVLTDDQDV-ELG-----SLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSML 95
RPNI+L++ DD + ++G +++ N R + G +C PSR++ L
Sbjct: 37 RPNILLLMADDLGIGDIGCYGNNTMRTPNIDR--LAEDGVKLTQHISAASLCTPSRAAFL 94
Query: 96 TGKYVHNHNVYTNNE----NCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKY 143
TG+Y + ++ + S TFA L GY T GK+
Sbjct: 95 TGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKILKEKGYATGLIGKW 146
>gi|146229331 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 46.2 bits (108), Expect = 1e-04
Identities = 34/113 (30%), Positives = 55/113 (48%), Gaps = 8/113 (7%)
Query: 285 TLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHI------GQFGLVK-GKSMPYDFD 337
+LM +D +V L + + G LE T +I+TAD+G G GL++ GK Y+
Sbjct: 250 SLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGG 309
Query: 338 IRVPFFIRGPSVEPGSIVPQIVLNIDLAPTILDIAGLDTP-PDVDGKSVLKLL 389
+R P P + ++ ++DL PT+ +AG P +DG + LL
Sbjct: 310 VREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLL 362
Score = 45.4 bits (106), Expect = 2e-04
Identities = 38/128 (29%), Positives = 60/128 (46%), Gaps = 9/128 (7%)
Query: 43 PNIILVLTDDQDV-ELGSLQVMNKTRKIMEH---GGATFINAFVTTPMCCPSRSSMLTGK 98
PNI+L+ DD +LG + T ++ GG F + +V +C PSR+++LTG+
Sbjct: 21 PNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGR 80
Query: 99 YVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKYLNEY--NGSYIPP-- 154
+Y SS + E T A L GY T GK+ G+++PP
Sbjct: 81 LPVRMGMYPGVLVPSSRGGLPLEEV-TVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQ 139
Query: 155 GWREWLGL 162
G+ +LG+
Sbjct: 140 GFHRFLGI 147
>gi|146229329 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 46.2 bits (108), Expect = 1e-04
Identities = 34/113 (30%), Positives = 55/113 (48%), Gaps = 8/113 (7%)
Query: 285 TLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHI------GQFGLVK-GKSMPYDFD 337
+LM +D +V L + + G LE T +I+TAD+G G GL++ GK Y+
Sbjct: 250 SLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGG 309
Query: 338 IRVPFFIRGPSVEPGSIVPQIVLNIDLAPTILDIAGLDTP-PDVDGKSVLKLL 389
+R P P + ++ ++DL PT+ +AG P +DG + LL
Sbjct: 310 VREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLL 362
Score = 45.4 bits (106), Expect = 2e-04
Identities = 38/128 (29%), Positives = 60/128 (46%), Gaps = 9/128 (7%)
Query: 43 PNIILVLTDDQDV-ELGSLQVMNKTRKIMEH---GGATFINAFVTTPMCCPSRSSMLTGK 98
PNI+L+ DD +LG + T ++ GG F + +V +C PSR+++LTG+
Sbjct: 21 PNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGR 80
Query: 99 YVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKYLNEY--NGSYIPP-- 154
+Y SS + E T A L GY T GK+ G+++PP
Sbjct: 81 LPVRMGMYPGVLVPSSRGGLPLEEV-TVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQ 139
Query: 155 GWREWLGL 162
G+ +LG+
Sbjct: 140 GFHRFLGI 147
>gi|146229327 arylsulfatase A isoform b [Homo sapiens]
Length = 423
Score = 46.2 bits (108), Expect = 1e-04
Identities = 34/113 (30%), Positives = 55/113 (48%), Gaps = 8/113 (7%)
Query: 285 TLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHI------GQFGLVK-GKSMPYDFD 337
+LM +D +V L + + G LE T +I+TAD+G G GL++ GK Y+
Sbjct: 166 SLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGG 225
Query: 338 IRVPFFIRGPSVEPGSIVPQIVLNIDLAPTILDIAGLDTP-PDVDGKSVLKLL 389
+R P P + ++ ++DL PT+ +AG P +DG + LL
Sbjct: 226 VREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLL 278
>gi|146229324 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 46.2 bits (108), Expect = 1e-04
Identities = 34/113 (30%), Positives = 55/113 (48%), Gaps = 8/113 (7%)
Query: 285 TLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHI------GQFGLVK-GKSMPYDFD 337
+LM +D +V L + + G LE T +I+TAD+G G GL++ GK Y+
Sbjct: 250 SLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGG 309
Query: 338 IRVPFFIRGPSVEPGSIVPQIVLNIDLAPTILDIAGLDTP-PDVDGKSVLKLL 389
+R P P + ++ ++DL PT+ +AG P +DG + LL
Sbjct: 310 VREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLL 362
Score = 45.4 bits (106), Expect = 2e-04
Identities = 38/128 (29%), Positives = 60/128 (46%), Gaps = 9/128 (7%)
Query: 43 PNIILVLTDDQDV-ELGSLQVMNKTRKIMEH---GGATFINAFVTTPMCCPSRSSMLTGK 98
PNI+L+ DD +LG + T ++ GG F + +V +C PSR+++LTG+
Sbjct: 21 PNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGR 80
Query: 99 YVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKYLNEY--NGSYIPP-- 154
+Y SS + E T A L GY T GK+ G+++PP
Sbjct: 81 LPVRMGMYPGVLVPSSRGGLPLEEV-TVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQ 139
Query: 155 GWREWLGL 162
G+ +LG+
Sbjct: 140 GFHRFLGI 147
>gi|6005990 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 46.2 bits (108), Expect = 1e-04
Identities = 34/113 (30%), Positives = 55/113 (48%), Gaps = 8/113 (7%)
Query: 285 TLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHI------GQFGLVK-GKSMPYDFD 337
+LM +D +V L + + G LE T +I+TAD+G G GL++ GK Y+
Sbjct: 250 SLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGG 309
Query: 338 IRVPFFIRGPSVEPGSIVPQIVLNIDLAPTILDIAGLDTP-PDVDGKSVLKLL 389
+R P P + ++ ++DL PT+ +AG P +DG + LL
Sbjct: 310 VREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLL 362
Score = 45.4 bits (106), Expect = 2e-04
Identities = 38/128 (29%), Positives = 60/128 (46%), Gaps = 9/128 (7%)
Query: 43 PNIILVLTDDQDV-ELGSLQVMNKTRKIMEH---GGATFINAFVTTPMCCPSRSSMLTGK 98
PNI+L+ DD +LG + T ++ GG F + +V +C PSR+++LTG+
Sbjct: 21 PNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGR 80
Query: 99 YVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKYLNEY--NGSYIPP-- 154
+Y SS + E T A L GY T GK+ G+++PP
Sbjct: 81 LPVRMGMYPGVLVPSSRGGLPLEEV-TVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQ 139
Query: 155 GWREWLGL 162
G+ +LG+
Sbjct: 140 GFHRFLGI 147
>gi|239508778 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 123
Score = 42.0 bits (97), Expect = 0.002
Identities = 21/71 (29%), Positives = 41/71 (57%)
Query: 668 KRRKPEECSCSKQSYYNKEKGVKKQEKLKSHLHPFKEAAQEVDSKLQLFKENNRRRKKER 727
K++K +E K+ ++K +K++K K +E +E + K + KE RRRKK++
Sbjct: 42 KKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKK 101
Query: 728 KEKRRQRKGEE 738
K +R++ + E+
Sbjct: 102 KRRRKEEEEEK 112
Score = 36.6 bits (83), Expect = 0.10
Identities = 22/68 (32%), Positives = 41/68 (60%), Gaps = 8/68 (11%)
Query: 668 KRRKPEECSCSKQSYYNKEKGVKKQEKLKSHLHPFKEAAQEVDSKLQLFKENNRRRKKER 727
K+++ EE ++++ +EK K++EK KE +E + K + KE +R++KE
Sbjct: 6 KKKETEETEETEETEEEEEKEGKRKEKR-------KEKRKEKEKKKKT-KETEKRKEKEE 57
Query: 728 KEKRRQRK 735
+EK+R+RK
Sbjct: 58 EEKKRKRK 65
Score = 32.0 bits (71), Expect = 2.6
Identities = 22/83 (26%), Positives = 40/83 (48%), Gaps = 5/83 (6%)
Query: 656 KIKNLREVRGHLKRRKPEECSCSKQSYYNKEKGVKKQEKLKSHLHPFKEAAQEVDSKLQL 715
K K E + + EE K+ KEK +K++K K+ KE + + + +
Sbjct: 5 KKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKT-----KETEKRKEKEEEE 59
Query: 716 FKENNRRRKKERKEKRRQRKGEE 738
K +R+KK+ +E+R + + EE
Sbjct: 60 KKRKRKRKKKKEEEEREEEEEEE 82
Score = 31.2 bits (69), Expect = 4.4
Identities = 22/88 (25%), Positives = 48/88 (54%), Gaps = 5/88 (5%)
Query: 648 KEIEALQDKIKNLREVRGHLKRRKPEECSCSKQSYYNKEKGVKKQEKLKSHLHPFKEAAQ 707
+E E ++K +E R KR++ E+ +K++ EK +K+E+ K K+ +
Sbjct: 17 EETEEEEEKEGKRKEKRKE-KRKEKEKKKKTKET----EKRKEKEEEEKKRKRKRKKKKE 71
Query: 708 EVDSKLQLFKENNRRRKKERKEKRRQRK 735
E + + + +E + ++E++E RR++K
Sbjct: 72 EEEREEEEEEEEEEKEEEEKEEGRRRKK 99
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,994,590
Number of Sequences: 37866
Number of extensions: 1781397
Number of successful extensions: 8115
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 80
Number of HSP's successfully gapped in prelim test: 218
Number of HSP's that attempted gapping in prelim test: 6849
Number of HSP's gapped (non-prelim): 1137
length of query: 871
length of database: 18,247,518
effective HSP length: 111
effective length of query: 760
effective length of database: 14,044,392
effective search space: 10673737920
effective search space used: 10673737920
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.