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Search of human proteins with 189491759
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens]
(559 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens] 1120 0.0
gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens] 1108 0.0
gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens] 1081 0.0
gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens] 1077 0.0
gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens] 1077 0.0
gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens] 1077 0.0
gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens] 862 0.0
gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens] 820 0.0
gi|32483399 p21-activated kinase 2 [Homo sapiens] 783 0.0
gi|62422561 p21-activated kinase 4 isoform 2 [Homo sapiens] 349 3e-96
gi|62422563 p21-activated kinase 4 isoform 2 [Homo sapiens] 349 3e-96
gi|62422554 p21-activated kinase 4 isoform 1 [Homo sapiens] 319 4e-87
gi|62422557 p21-activated kinase 4 isoform 1 [Homo sapiens] 319 4e-87
gi|5031975 p21-activated kinase 4 isoform 1 [Homo sapiens] 319 4e-87
gi|29826329 p21-activated kinase 7 [Homo sapiens] 316 4e-86
gi|24308191 p21-activated kinase 7 [Homo sapiens] 316 4e-86
gi|191252782 p21-activated kinase 6 [Homo sapiens] 302 5e-82
gi|191252780 p21-activated kinase 6 [Homo sapiens] 302 5e-82
gi|9910476 p21-activated kinase 6 [Homo sapiens] 302 5e-82
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 244 2e-64
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 244 2e-64
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 239 4e-63
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 238 8e-63
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 238 8e-63
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 236 4e-62
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 214 2e-55
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 213 5e-55
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 206 3e-53
gi|145275208 myosin IIIA [Homo sapiens] 203 3e-52
gi|45439370 TAO kinase 1 [Homo sapiens] 202 5e-52
>gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens]
Length = 559
Score = 1120 bits (2898), Expect = 0.0
Identities = 559/559 (100%), Positives = 559/559 (100%)
Query: 1 MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN 60
MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN
Sbjct: 1 MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN 60
Query: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQTS 120
KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQTS
Sbjct: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQTS 120
Query: 121 NITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTASEPP 180
NITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTASEPP
Sbjct: 121 NITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTASEPP 180
Query: 181 LAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSA 240
LAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSA
Sbjct: 181 LAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSA 240
Query: 241 ENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTA 300
ENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTA
Sbjct: 241 ENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTA 300
Query: 301 LDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYL 360
LDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYL
Sbjct: 301 LDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYL 360
Query: 361 AGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTD 420
AGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTD
Sbjct: 361 AGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTD 420
Query: 421 FGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNE 480
FGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNE
Sbjct: 421 FGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNE 480
Query: 481 NPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPL 540
NPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPL
Sbjct: 481 NPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPL 540
Query: 541 SSLTPLIIAAKEAIKNSSR 559
SSLTPLIIAAKEAIKNSSR
Sbjct: 541 SSLTPLIIAAKEAIKNSSR 559
>gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens]
Length = 580
Score = 1108 bits (2866), Expect = 0.0
Identities = 559/580 (96%), Positives = 559/580 (96%), Gaps = 21/580 (3%)
Query: 1 MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN 60
MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN
Sbjct: 1 MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN 60
Query: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFT---------------------PDLYGSQ 99
KKKEKERPEISLPSDFEHTIHVGFDAVTGEFT PDLYGSQ
Sbjct: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKMPDLYGSQ 120
Query: 100 MCPGKLPEGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGD 159
MCPGKLPEGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGD
Sbjct: 121 MCPGKLPEGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGD 180
Query: 160 KSAHGYIAAHPSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTR 219
KSAHGYIAAHPSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTR
Sbjct: 181 KSAHGYIAAHPSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTR 240
Query: 220 SVVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDP 279
SVVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDP
Sbjct: 241 SVVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDP 300
Query: 280 KKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPN 339
KKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPN
Sbjct: 301 KKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPN 360
Query: 340 IVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVI 399
IVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVI
Sbjct: 361 IVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVI 420
Query: 400 HRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVD 459
HRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVD
Sbjct: 421 HRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVD 480
Query: 460 IWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDV 519
IWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDV
Sbjct: 481 IWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDV 540
Query: 520 DRRGSAKELLQHPFLKLAKPLSSLTPLIIAAKEAIKNSSR 559
DRRGSAKELLQHPFLKLAKPLSSLTPLIIAAKEAIKNSSR
Sbjct: 541 DRRGSAKELLQHPFLKLAKPLSSLTPLIIAAKEAIKNSSR 580
>gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens]
Length = 565
Score = 1081 bits (2796), Expect = 0.0
Identities = 548/567 (96%), Positives = 549/567 (96%), Gaps = 10/567 (1%)
Query: 1 MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN 60
MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN
Sbjct: 1 MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN 60
Query: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFT--------PDLYGSQMCPGKLPEGIPEQ 112
KKKEKERPEISLPSDFEHTIHVGFDAVTGEFT P S GK+ GIPEQ
Sbjct: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKM--GIPEQ 118
Query: 113 WARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSS 172
WARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSS
Sbjct: 119 WARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSS 178
Query: 173 TKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPN 232
TKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPN
Sbjct: 179 TKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPN 238
Query: 233 KEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQG 292
KEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQG
Sbjct: 239 KEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQG 298
Query: 293 ASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDE 352
ASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDE
Sbjct: 299 ASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDE 358
Query: 353 LWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGM 412
LWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGM
Sbjct: 359 LWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGM 418
Query: 413 DGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVE 472
DGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVE
Sbjct: 419 DGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVE 478
Query: 473 GEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHP 532
GEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHP
Sbjct: 479 GEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHP 538
Query: 533 FLKLAKPLSSLTPLIIAAKEAIKNSSR 559
FLKLAKPLSSLTPLIIAAKEAIKNSSR
Sbjct: 539 FLKLAKPLSSLTPLIIAAKEAIKNSSR 565
>gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 1077 bits (2785), Expect = 0.0
Identities = 544/559 (97%), Positives = 544/559 (97%), Gaps = 15/559 (2%)
Query: 1 MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN 60
MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN
Sbjct: 1 MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN 60
Query: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQTS 120
KKKEKERPEISLPSDFEHTIHVGFDAVTGEFT GIPEQWARLLQTS
Sbjct: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFT---------------GIPEQWARLLQTS 105
Query: 121 NITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTASEPP 180
NITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTASEPP
Sbjct: 106 NITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTASEPP 165
Query: 181 LAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSA 240
LAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSA
Sbjct: 166 LAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSA 225
Query: 241 ENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTA 300
ENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTA
Sbjct: 226 ENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTA 285
Query: 301 LDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYL 360
LDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYL
Sbjct: 286 LDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYL 345
Query: 361 AGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTD 420
AGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTD
Sbjct: 346 AGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTD 405
Query: 421 FGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNE 480
FGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNE
Sbjct: 406 FGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNE 465
Query: 481 NPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPL 540
NPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPL
Sbjct: 466 NPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPL 525
Query: 541 SSLTPLIIAAKEAIKNSSR 559
SSLTPLIIAAKEAIKNSSR
Sbjct: 526 SSLTPLIIAAKEAIKNSSR 544
>gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 1077 bits (2785), Expect = 0.0
Identities = 544/559 (97%), Positives = 544/559 (97%), Gaps = 15/559 (2%)
Query: 1 MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN 60
MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN
Sbjct: 1 MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN 60
Query: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQTS 120
KKKEKERPEISLPSDFEHTIHVGFDAVTGEFT GIPEQWARLLQTS
Sbjct: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFT---------------GIPEQWARLLQTS 105
Query: 121 NITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTASEPP 180
NITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTASEPP
Sbjct: 106 NITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTASEPP 165
Query: 181 LAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSA 240
LAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSA
Sbjct: 166 LAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSA 225
Query: 241 ENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTA 300
ENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTA
Sbjct: 226 ENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTA 285
Query: 301 LDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYL 360
LDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYL
Sbjct: 286 LDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYL 345
Query: 361 AGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTD 420
AGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTD
Sbjct: 346 AGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTD 405
Query: 421 FGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNE 480
FGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNE
Sbjct: 406 FGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNE 465
Query: 481 NPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPL 540
NPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPL
Sbjct: 466 NPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPL 525
Query: 541 SSLTPLIIAAKEAIKNSSR 559
SSLTPLIIAAKEAIKNSSR
Sbjct: 526 SSLTPLIIAAKEAIKNSSR 544
>gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 1077 bits (2785), Expect = 0.0
Identities = 544/559 (97%), Positives = 544/559 (97%), Gaps = 15/559 (2%)
Query: 1 MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN 60
MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN
Sbjct: 1 MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN 60
Query: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQTS 120
KKKEKERPEISLPSDFEHTIHVGFDAVTGEFT GIPEQWARLLQTS
Sbjct: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFT---------------GIPEQWARLLQTS 105
Query: 121 NITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTASEPP 180
NITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTASEPP
Sbjct: 106 NITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTASEPP 165
Query: 181 LAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSA 240
LAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSA
Sbjct: 166 LAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSA 225
Query: 241 ENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTA 300
ENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTA
Sbjct: 226 ENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTA 285
Query: 301 LDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYL 360
LDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYL
Sbjct: 286 LDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYL 345
Query: 361 AGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTD 420
AGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTD
Sbjct: 346 AGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTD 405
Query: 421 FGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNE 480
FGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNE
Sbjct: 406 FGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNE 465
Query: 481 NPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPL 540
NPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPL
Sbjct: 466 NPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPL 525
Query: 541 SSLTPLIIAAKEAIKNSSR 559
SSLTPLIIAAKEAIKNSSR
Sbjct: 526 SSLTPLIIAAKEAIKNSSR 544
>gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens]
Length = 545
Score = 862 bits (2226), Expect = 0.0
Identities = 445/567 (78%), Positives = 489/567 (86%), Gaps = 36/567 (6%)
Query: 2 SDGLDNEEKPPAPPLRMNSN-----NRDSSALNHSSKPLPMAPEEKNKKARL-RSIFPGG 55
++GLD ++KPPAPP+R S ++D+ LNH SKPLP PEEK KK R RSI PG
Sbjct: 3 NNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPG- 61
Query: 56 GDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWAR 115
DKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFT G+PEQWAR
Sbjct: 62 -DKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFT---------------GMPEQWAR 105
Query: 116 LLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKT 175
LLQTSNITK EQKKNPQAVLDVL+FY+SK+T N+QKYMSFT DKSA Y +++ + K
Sbjct: 106 LLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFT--DKSAEDYNSSNALNVKA 163
Query: 176 ASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEV 235
SE P PPVSE+ED+++ D+ PPPVIAPRPEHTKS+YTRSV+E + P P ++V
Sbjct: 164 VSETPAVPPVSEDEDDDD----DDATPPPVIAPRPEHTKSVYTRSVIEPL--PVTPTRDV 217
Query: 236 -TPPSAENANSST----LYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIG 290
T P + N++T L RNT++Q+KK KM+DEEILEKLRSIVSVGDPKKKYTRFEKIG
Sbjct: 218 ATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIG 277
Query: 291 QGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG 350
QGASGTVYTA+D+ATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG
Sbjct: 278 QGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG 337
Query: 351 DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILL 410
DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQAL+FLHSNQVIHRDIKSDNILL
Sbjct: 338 DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILL 397
Query: 411 GMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEM 470
GMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEM
Sbjct: 398 GMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEM 457
Query: 471 VEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
+EGEPPYLNENPLRALYLIATNGTPELQNPE+LSA+FRDFLNRCLEMDV++RGSAKELLQ
Sbjct: 458 IEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQ 517
Query: 531 HPFLKLAKPLSSLTPLIIAAKEAIKNS 557
H FLK+AKPLSSLTPLI AAKEA KN+
Sbjct: 518 HQFLKIAKPLSSLTPLIAAAKEATKNN 544
>gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens]
Length = 553
Score = 820 bits (2118), Expect = 0.0
Identities = 423/540 (78%), Positives = 465/540 (86%), Gaps = 36/540 (6%)
Query: 2 SDGLDNEEKPPAPPLRMNSN-----NRDSSALNHSSKPLPMAPEEKNKKARL-RSIFPGG 55
++GLD ++KPPAPP+R S ++D+ LNH SKPLP PEEK KK R RSI PG
Sbjct: 3 NNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPG- 61
Query: 56 GDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWAR 115
DKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFT G+PEQWAR
Sbjct: 62 -DKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFT---------------GMPEQWAR 105
Query: 116 LLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKT 175
LLQTSNITK EQKKNPQAVLDVL+FY+SK+T N+QKYMSFT DKSA Y +++ + K
Sbjct: 106 LLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFT--DKSAEDYNSSNALNVKA 163
Query: 176 ASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEV 235
SE P PPVSE+ED+++ D+ PPPVIAPRPEHTKS+YTRSV+E + P P ++V
Sbjct: 164 VSETPAVPPVSEDEDDDD----DDATPPPVIAPRPEHTKSVYTRSVIEPL--PVTPTRDV 217
Query: 236 -TPPSAENANSST----LYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIG 290
T P + N++T L RNT++Q+KK KM+DEEILEKLRSIVSVGDPKKKYTRFEKIG
Sbjct: 218 ATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIG 277
Query: 291 QGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG 350
QGASGTVYTA+D+ATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG
Sbjct: 278 QGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVG 337
Query: 351 DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILL 410
DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQAL+FLHSNQVIHRDIKSDNILL
Sbjct: 338 DELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILL 397
Query: 411 GMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEM 470
GMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEM
Sbjct: 398 GMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEM 457
Query: 471 VEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQ 530
+EGEPPYLNENPLRALYLIATNGTPELQNPE+LSA+FRDFLNRCLEMDV++RGSAKELLQ
Sbjct: 458 IEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQ 517
>gi|32483399 p21-activated kinase 2 [Homo sapiens]
Length = 524
Score = 783 bits (2022), Expect = 0.0
Identities = 407/562 (72%), Positives = 464/562 (82%), Gaps = 44/562 (7%)
Query: 1 MSDGLDNEEKPPAPPLRMNSN-----NRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGG 55
MSD + E+KPPAPP+RM+S +D + NHS KPLP PEEK + ++ SIF G
Sbjct: 1 MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRHKIISIF-SG 59
Query: 56 GDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWAR 115
+K +KKKEKERPEIS PSDFEHTIHVGFDAVTGEFT G+PEQWAR
Sbjct: 60 TEKGSKKKEKERPEISPPSDFEHTIHVGFDAVTGEFT---------------GMPEQWAR 104
Query: 116 LLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKT 175
LLQTSNITKLEQKKNPQAVLDVLKFYDS QKY+SFT +K G+ + P+
Sbjct: 105 LLQTSNITKLEQKKNPQAVLDVLKFYDSNTV--KQKYLSFTPPEKD--GFPSGTPALNAK 160
Query: 176 ASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEV 235
+E P V+EEED++EE PPVIAPRP+HTKSIYTRSV++ + +P
Sbjct: 161 GTEAPAV--VTEEEDDDEETA------PPVIAPRPDHTKSIYTRSVIDPVPAPV------ 206
Query: 236 TPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASG 295
+++ ++ D+Q+KK+KMTDEEI+EKLR+IVS+GDPKKKYTR+EKIGQGASG
Sbjct: 207 -----GDSHVDGAAKSLDKQKKKTKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASG 261
Query: 296 TVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWV 355
TV+TA D+A GQEVAIKQ+NLQ+QPKKELIINEILVM+E KNPNIVN+LDSYLVGDEL+V
Sbjct: 262 TVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFV 321
Query: 356 VMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGS 415
VMEYLAGGSLTDVVTETCMDE QIAAVCRECLQAL+FLH+NQVIHRDIKSDN+LLGM+GS
Sbjct: 322 VMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGS 381
Query: 416 VKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEP 475
VKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEP
Sbjct: 382 VKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEP 441
Query: 476 PYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLK 535
PYLNENPLRALYLIATNGTPELQNPE+LS +FRDFLNRCLEMDV++RGSAKELLQHPFLK
Sbjct: 442 PYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLK 501
Query: 536 LAKPLSSLTPLIIAAKEAIKNS 557
LAKPLSSLTPLI+AAKEA+K++
Sbjct: 502 LAKPLSSLTPLIMAAKEAMKSN 523
>gi|62422561 p21-activated kinase 4 isoform 2 [Homo sapiens]
Length = 438
Score = 349 bits (896), Expect = 3e-96
Identities = 199/485 (41%), Positives = 280/485 (57%), Gaps = 56/485 (11%)
Query: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQTSNI 122
K K+R EIS PS+FEH +H GFD +FT G+P QW L++
Sbjct: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFT---------------GLPRQWQSLIE---- 44
Query: 123 TKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTASEPPLA 182
E + P+ ++D + + SA G A P S+ ++S PP
Sbjct: 45 ---ESARRPKPLVDPACITSIQPGAPKGEPHDVAPNGPSAGGL--AIPQSSSSSSRPPTR 99
Query: 183 PPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSAEN 242
+ + PP P A+PAVP PP +
Sbjct: 100 ARGAPSPGVLGPHASEPQLAPPACTP-----------------AAPAVPG----PPGPRS 138
Query: 243 ANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALD 302
QR+ +++ E+ L+ +V GDP+ F KIG+G++G V A
Sbjct: 139 P-----------QREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATV 187
Query: 303 IATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAG 362
++G+ VA+K+M+L++Q ++EL+ NE+++MR+ ++ N+V +SYLVGDELWVVME+L G
Sbjct: 188 RSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEG 247
Query: 363 GSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFG 422
G+LTD+VT T M+E QIAAVC LQAL LH+ VIHRDIKSD+ILL DG VKL+DFG
Sbjct: 248 GALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFG 307
Query: 423 FCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENP 482
FCAQ++ E +R ++VGTPYWMAPE+++R YGP+VDIWSLGIM IEMV+GEPPY NE P
Sbjct: 308 FCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPP 367
Query: 483 LRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSS 542
L+A+ +I N P L+N ++S + FL+R L D +R +A ELL+HPFL A P +S
Sbjct: 368 LKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS 427
Query: 543 LTPLI 547
+ PL+
Sbjct: 428 IVPLM 432
>gi|62422563 p21-activated kinase 4 isoform 2 [Homo sapiens]
Length = 438
Score = 349 bits (896), Expect = 3e-96
Identities = 199/485 (41%), Positives = 280/485 (57%), Gaps = 56/485 (11%)
Query: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQTSNI 122
K K+R EIS PS+FEH +H GFD +FT G+P QW L++
Sbjct: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFT---------------GLPRQWQSLIE---- 44
Query: 123 TKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTASEPPLA 182
E + P+ ++D + + SA G A P S+ ++S PP
Sbjct: 45 ---ESARRPKPLVDPACITSIQPGAPKGEPHDVAPNGPSAGGL--AIPQSSSSSSRPPTR 99
Query: 183 PPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSAEN 242
+ + PP P A+PAVP PP +
Sbjct: 100 ARGAPSPGVLGPHASEPQLAPPACTP-----------------AAPAVPG----PPGPRS 138
Query: 243 ANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALD 302
QR+ +++ E+ L+ +V GDP+ F KIG+G++G V A
Sbjct: 139 P-----------QREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATV 187
Query: 303 IATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAG 362
++G+ VA+K+M+L++Q ++EL+ NE+++MR+ ++ N+V +SYLVGDELWVVME+L G
Sbjct: 188 RSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEG 247
Query: 363 GSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFG 422
G+LTD+VT T M+E QIAAVC LQAL LH+ VIHRDIKSD+ILL DG VKL+DFG
Sbjct: 248 GALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFG 307
Query: 423 FCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENP 482
FCAQ++ E +R ++VGTPYWMAPE+++R YGP+VDIWSLGIM IEMV+GEPPY NE P
Sbjct: 308 FCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPP 367
Query: 483 LRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSS 542
L+A+ +I N P L+N ++S + FL+R L D +R +A ELL+HPFL A P +S
Sbjct: 368 LKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS 427
Query: 543 LTPLI 547
+ PL+
Sbjct: 428 IVPLM 432
>gi|62422554 p21-activated kinase 4 isoform 1 [Homo sapiens]
Length = 591
Score = 319 bits (818), Expect = 4e-87
Identities = 171/380 (45%), Positives = 239/380 (62%), Gaps = 32/380 (8%)
Query: 168 AHPSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIAS 227
A P S+ ++S PP + + PP P A+
Sbjct: 238 AIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTP-----------------AA 280
Query: 228 PAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFE 287
PAVP PP + QR+ +++ E+ L+ +V GDP+ F
Sbjct: 281 PAVPG----PPGPRSP-----------QREPQRVSHEQFRAALQLVVDPGDPRSYLDNFI 325
Query: 288 KIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSY 347
KIG+G++G V A ++G+ VA+K+M+L++Q ++EL+ NE+++MR+ ++ N+V +SY
Sbjct: 326 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSY 385
Query: 348 LVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDN 407
LVGDELWVVME+L GG+LTD+VT T M+E QIAAVC LQAL LH+ VIHRDIKSD+
Sbjct: 386 LVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDS 445
Query: 408 ILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMA 467
ILL DG VKL+DFGFCAQ++ E +R ++VGTPYWMAPE+++R YGP+VDIWSLGIM
Sbjct: 446 ILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMV 505
Query: 468 IEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKE 527
IEMV+GEPPY NE PL+A+ +I N P L+N ++S + FL+R L D +R +A E
Sbjct: 506 IEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAE 565
Query: 528 LLQHPFLKLAKPLSSLTPLI 547
LL+HPFL A P +S+ PL+
Sbjct: 566 LLKHPFLAKAGPPASIVPLM 585
Score = 44.7 bits (104), Expect = 2e-04
Identities = 23/58 (39%), Positives = 30/58 (51%), Gaps = 15/58 (25%)
Query: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQTS 120
K K+R EIS PS+FEH +H GFD +FT G+P QW L++ S
Sbjct: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFT---------------GLPRQWQSLIEES 46
>gi|62422557 p21-activated kinase 4 isoform 1 [Homo sapiens]
Length = 591
Score = 319 bits (818), Expect = 4e-87
Identities = 171/380 (45%), Positives = 239/380 (62%), Gaps = 32/380 (8%)
Query: 168 AHPSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIAS 227
A P S+ ++S PP + + PP P A+
Sbjct: 238 AIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTP-----------------AA 280
Query: 228 PAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFE 287
PAVP PP + QR+ +++ E+ L+ +V GDP+ F
Sbjct: 281 PAVPG----PPGPRSP-----------QREPQRVSHEQFRAALQLVVDPGDPRSYLDNFI 325
Query: 288 KIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSY 347
KIG+G++G V A ++G+ VA+K+M+L++Q ++EL+ NE+++MR+ ++ N+V +SY
Sbjct: 326 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSY 385
Query: 348 LVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDN 407
LVGDELWVVME+L GG+LTD+VT T M+E QIAAVC LQAL LH+ VIHRDIKSD+
Sbjct: 386 LVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDS 445
Query: 408 ILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMA 467
ILL DG VKL+DFGFCAQ++ E +R ++VGTPYWMAPE+++R YGP+VDIWSLGIM
Sbjct: 446 ILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMV 505
Query: 468 IEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKE 527
IEMV+GEPPY NE PL+A+ +I N P L+N ++S + FL+R L D +R +A E
Sbjct: 506 IEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAE 565
Query: 528 LLQHPFLKLAKPLSSLTPLI 547
LL+HPFL A P +S+ PL+
Sbjct: 566 LLKHPFLAKAGPPASIVPLM 585
Score = 44.7 bits (104), Expect = 2e-04
Identities = 23/58 (39%), Positives = 30/58 (51%), Gaps = 15/58 (25%)
Query: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQTS 120
K K+R EIS PS+FEH +H GFD +FT G+P QW L++ S
Sbjct: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFT---------------GLPRQWQSLIEES 46
>gi|5031975 p21-activated kinase 4 isoform 1 [Homo sapiens]
Length = 591
Score = 319 bits (818), Expect = 4e-87
Identities = 171/380 (45%), Positives = 239/380 (62%), Gaps = 32/380 (8%)
Query: 168 AHPSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIAS 227
A P S+ ++S PP + + PP P A+
Sbjct: 238 AIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTP-----------------AA 280
Query: 228 PAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFE 287
PAVP PP + QR+ +++ E+ L+ +V GDP+ F
Sbjct: 281 PAVPG----PPGPRSP-----------QREPQRVSHEQFRAALQLVVDPGDPRSYLDNFI 325
Query: 288 KIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSY 347
KIG+G++G V A ++G+ VA+K+M+L++Q ++EL+ NE+++MR+ ++ N+V +SY
Sbjct: 326 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSY 385
Query: 348 LVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDN 407
LVGDELWVVME+L GG+LTD+VT T M+E QIAAVC LQAL LH+ VIHRDIKSD+
Sbjct: 386 LVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDS 445
Query: 408 ILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMA 467
ILL DG VKL+DFGFCAQ++ E +R ++VGTPYWMAPE+++R YGP+VDIWSLGIM
Sbjct: 446 ILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMV 505
Query: 468 IEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKE 527
IEMV+GEPPY NE PL+A+ +I N P L+N ++S + FL+R L D +R +A E
Sbjct: 506 IEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAE 565
Query: 528 LLQHPFLKLAKPLSSLTPLI 547
LL+HPFL A P +S+ PL+
Sbjct: 566 LLKHPFLAKAGPPASIVPLM 585
Score = 44.7 bits (104), Expect = 2e-04
Identities = 23/58 (39%), Positives = 30/58 (51%), Gaps = 15/58 (25%)
Query: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQTS 120
K K+R EIS PS+FEH +H GFD +FT G+P QW L++ S
Sbjct: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFT---------------GLPRQWQSLIEES 46
>gi|29826329 p21-activated kinase 7 [Homo sapiens]
Length = 719
Score = 316 bits (809), Expect = 4e-86
Identities = 152/292 (52%), Positives = 218/292 (74%)
Query: 256 RKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN 315
++ S+++ E+ L+ +VS GDP++ F KIG+G++G V A + TG++VA+K+M+
Sbjct: 422 QQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMD 481
Query: 316 LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMD 375
L++Q ++EL+ NE+++MR+ + N+V+ SYLVGDELWVVME+L GG+LTD+VT T M+
Sbjct: 482 LRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMN 541
Query: 376 EGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS 435
E QIA VC L+AL +LH+ VIHRDIKSD+ILL DG +KL+DFGFCAQ++ E KR
Sbjct: 542 EEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRK 601
Query: 436 TMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTP 495
++VGTPYWMAPEV++R YG +VDIWSLGIM IEM++GEPPY NE PL+A+ I + P
Sbjct: 602 SLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPP 661
Query: 496 ELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLI 547
+++ ++S+V R FL+ L + +R +A+ELL HPFLKLA P S + PL+
Sbjct: 662 RVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLM 713
Score = 42.4 bits (98), Expect = 0.001
Identities = 25/63 (39%), Positives = 34/63 (53%), Gaps = 16/63 (25%)
Query: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLL-QTSN 121
K+K++ EIS PS+FEH +H GFD +FT G+P+QW LL T+N
Sbjct: 4 KKKKKIEISGPSNFEHRVHTGFDPQEQKFT---------------GLPQQWHSLLADTAN 48
Query: 122 ITK 124
K
Sbjct: 49 RPK 51
>gi|24308191 p21-activated kinase 7 [Homo sapiens]
Length = 719
Score = 316 bits (809), Expect = 4e-86
Identities = 152/292 (52%), Positives = 218/292 (74%)
Query: 256 RKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN 315
++ S+++ E+ L+ +VS GDP++ F KIG+G++G V A + TG++VA+K+M+
Sbjct: 422 QQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMD 481
Query: 316 LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMD 375
L++Q ++EL+ NE+++MR+ + N+V+ SYLVGDELWVVME+L GG+LTD+VT T M+
Sbjct: 482 LRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMN 541
Query: 376 EGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS 435
E QIA VC L+AL +LH+ VIHRDIKSD+ILL DG +KL+DFGFCAQ++ E KR
Sbjct: 542 EEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRK 601
Query: 436 TMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTP 495
++VGTPYWMAPEV++R YG +VDIWSLGIM IEM++GEPPY NE PL+A+ I + P
Sbjct: 602 SLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPP 661
Query: 496 ELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLI 547
+++ ++S+V R FL+ L + +R +A+ELL HPFLKLA P S + PL+
Sbjct: 662 RVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLM 713
Score = 42.4 bits (98), Expect = 0.001
Identities = 25/63 (39%), Positives = 34/63 (53%), Gaps = 16/63 (25%)
Query: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLL-QTSN 121
K+K++ EIS PS+FEH +H GFD +FT G+P+QW LL T+N
Sbjct: 4 KKKKKIEISGPSNFEHRVHTGFDPQEQKFT---------------GLPQQWHSLLADTAN 48
Query: 122 ITK 124
K
Sbjct: 49 RPK 51
>gi|191252782 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 302 bits (774), Expect = 5e-82
Identities = 165/400 (41%), Positives = 243/400 (60%), Gaps = 20/400 (5%)
Query: 168 AHPSSTKTASEPPLAPPVSEEEDEEEE--------EEEDENEPPPVIAPRPEHTKSIYTR 219
A PSS+K P P S +++ + ++P +P S +
Sbjct: 272 APPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQK 331
Query: 220 SVVESIASPAVPNKEVTPPSAEN----ANSSTLYRNTDRQRKKSKM--------TDEEIL 267
S+ + A+ +P + S ++S LY D K + T E+
Sbjct: 332 SLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFK 391
Query: 268 EKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIIN 327
LR +V GDP+ + KIG+G++G V A + +G++VA+K M+L++Q ++EL+ N
Sbjct: 392 AALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFN 451
Query: 328 EILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECL 387
E+++MR+ ++ N+V SYLVG+ELWV+ME+L GG+LTD+V++ ++E QIA VC L
Sbjct: 452 EVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVL 511
Query: 388 QALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPE 447
QAL +LH+ VIHRDIKSD+ILL +DG VKL+DFGFCAQI+ + KR ++VGTPYWMAPE
Sbjct: 512 QALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPE 571
Query: 448 VVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVF 507
V++R Y +VDIWSLGIM IEMV+GEPPY +++P++A+ + + P+L+N ++S V
Sbjct: 572 VISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVL 631
Query: 508 RDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLI 547
RDFL R L D R +A+ELL HPFL L PLI
Sbjct: 632 RDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLI 671
Score = 47.8 bits (112), Expect = 3e-05
Identities = 22/59 (37%), Positives = 31/59 (52%), Gaps = 15/59 (25%)
Query: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQT 119
+KK+K+RPEIS P +F+H +H FD G+F G+P QW +L T
Sbjct: 3 RKKKKKRPEISAPQNFQHRVHTSFDPKEGKFV---------------GLPPQWQNILDT 46
>gi|191252780 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 302 bits (774), Expect = 5e-82
Identities = 165/400 (41%), Positives = 243/400 (60%), Gaps = 20/400 (5%)
Query: 168 AHPSSTKTASEPPLAPPVSEEEDEEEE--------EEEDENEPPPVIAPRPEHTKSIYTR 219
A PSS+K P P S +++ + ++P +P S +
Sbjct: 272 APPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQK 331
Query: 220 SVVESIASPAVPNKEVTPPSAEN----ANSSTLYRNTDRQRKKSKM--------TDEEIL 267
S+ + A+ +P + S ++S LY D K + T E+
Sbjct: 332 SLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFK 391
Query: 268 EKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIIN 327
LR +V GDP+ + KIG+G++G V A + +G++VA+K M+L++Q ++EL+ N
Sbjct: 392 AALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFN 451
Query: 328 EILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECL 387
E+++MR+ ++ N+V SYLVG+ELWV+ME+L GG+LTD+V++ ++E QIA VC L
Sbjct: 452 EVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVL 511
Query: 388 QALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPE 447
QAL +LH+ VIHRDIKSD+ILL +DG VKL+DFGFCAQI+ + KR ++VGTPYWMAPE
Sbjct: 512 QALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPE 571
Query: 448 VVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVF 507
V++R Y +VDIWSLGIM IEMV+GEPPY +++P++A+ + + P+L+N ++S V
Sbjct: 572 VISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVL 631
Query: 508 RDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLI 547
RDFL R L D R +A+ELL HPFL L PLI
Sbjct: 632 RDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLI 671
Score = 47.8 bits (112), Expect = 3e-05
Identities = 22/59 (37%), Positives = 31/59 (52%), Gaps = 15/59 (25%)
Query: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQT 119
+KK+K+RPEIS P +F+H +H FD G+F G+P QW +L T
Sbjct: 3 RKKKKKRPEISAPQNFQHRVHTSFDPKEGKFV---------------GLPPQWQNILDT 46
>gi|9910476 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 302 bits (774), Expect = 5e-82
Identities = 165/400 (41%), Positives = 243/400 (60%), Gaps = 20/400 (5%)
Query: 168 AHPSSTKTASEPPLAPPVSEEEDEEEE--------EEEDENEPPPVIAPRPEHTKSIYTR 219
A PSS+K P P S +++ + ++P +P S +
Sbjct: 272 APPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQK 331
Query: 220 SVVESIASPAVPNKEVTPPSAEN----ANSSTLYRNTDRQRKKSKM--------TDEEIL 267
S+ + A+ +P + S ++S LY D K + T E+
Sbjct: 332 SLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFK 391
Query: 268 EKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIIN 327
LR +V GDP+ + KIG+G++G V A + +G++VA+K M+L++Q ++EL+ N
Sbjct: 392 AALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFN 451
Query: 328 EILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECL 387
E+++MR+ ++ N+V SYLVG+ELWV+ME+L GG+LTD+V++ ++E QIA VC L
Sbjct: 452 EVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVL 511
Query: 388 QALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPE 447
QAL +LH+ VIHRDIKSD+ILL +DG VKL+DFGFCAQI+ + KR ++VGTPYWMAPE
Sbjct: 512 QALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPE 571
Query: 448 VVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVF 507
V++R Y +VDIWSLGIM IEMV+GEPPY +++P++A+ + + P+L+N ++S V
Sbjct: 572 VISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVL 631
Query: 508 RDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLI 547
RDFL R L D R +A+ELL HPFL L PLI
Sbjct: 632 RDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLI 671
Score = 47.8 bits (112), Expect = 3e-05
Identities = 22/59 (37%), Positives = 31/59 (52%), Gaps = 15/59 (25%)
Query: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQT 119
+KK+K+RPEIS P +F+H +H FD G+F G+P QW +L T
Sbjct: 3 RKKKKKRPEISAPQNFQHRVHTSFDPKEGKFV---------------GLPPQWQNILDT 46
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 244 bits (623), Expect = 2e-64
Identities = 123/288 (42%), Positives = 185/288 (64%), Gaps = 4/288 (1%)
Query: 267 LEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELII 326
L+KL P++ + EK+G+G+ G+V+ A+ +GQ VAIKQ+ ++ ++ II
Sbjct: 11 LKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQE--II 68
Query: 327 NEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVT--ETCMDEGQIAAVCR 384
EI +M++ +P +V Y SY +LW+VMEY GS++D++ + E +IA + +
Sbjct: 69 KEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILK 128
Query: 385 ECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWM 444
L+ L++LH + IHRDIK+ NILL +G KL DFG Q+T +KR+T++GTP+WM
Sbjct: 129 STLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWM 188
Query: 445 APEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLS 504
APEV+ Y DIWSLGI +IEM EG+PPY + +P+RA+++I TN P + PE S
Sbjct: 189 APEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWS 248
Query: 505 AVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLIIAAKE 552
F DF+ +CL + ++R +A +LLQHPF+K AKP+S L LI A E
Sbjct: 249 DDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAME 296
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 244 bits (623), Expect = 2e-64
Identities = 126/299 (42%), Positives = 189/299 (63%), Gaps = 12/299 (4%)
Query: 256 RKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN 315
R++ K DE+ L K P++ + EK+G+G+ G+VY A+ TGQ VAIKQ+
Sbjct: 11 RRQLKKLDEDSLTK--------QPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVP 62
Query: 316 LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVT--ETC 373
++ ++ II EI +M++ +P++V Y SY +LW+VMEY GS++D++
Sbjct: 63 VESDLQE--IIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKT 120
Query: 374 MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSK 433
+ E +IA + + L+ L++LH + IHRDIK+ NILL +G KL DFG Q+T +K
Sbjct: 121 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK 180
Query: 434 RSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNG 493
R+T++GTP+WMAPEV+ Y DIWSLGI AIEM EG+PPY + +P+RA+++I TN
Sbjct: 181 RNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNP 240
Query: 494 TPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLIIAAKE 552
P + PE S F DF+ +CL ++R +A +LLQHPF++ AK +S L LI A +
Sbjct: 241 PPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMD 299
Score = 29.6 bits (65), Expect = 7.6
Identities = 19/115 (16%), Positives = 45/115 (39%), Gaps = 3/115 (2%)
Query: 188 EEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSAENANSST 247
++D+EE EEDE + ++ + ++ S + A+ + + + P +
Sbjct: 313 DQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDTLP---SQLGTMV 369
Query: 248 LYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALD 302
+ + + K DE + S + + K+K + G+ G + + D
Sbjct: 370 INAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQINSFGKSVPGPLKNSSD 424
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 239 bits (611), Expect = 4e-63
Identities = 126/275 (45%), Positives = 179/275 (65%), Gaps = 4/275 (1%)
Query: 275 SVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILVMR 333
++ DP++ +T+ E+IG+G+ G V+ +D T Q VAIK ++L++ + + E I EI V+
Sbjct: 16 NIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLS 75
Query: 334 ENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFL 393
+ + + Y SYL G +LW++MEYL GGS D++ DE QIA + +E L+ LD+L
Sbjct: 76 QCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYL 135
Query: 394 HSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA 453
HS + IHRDIK+ N+LL G VKL DFG Q+T Q KR+T VGTP+WMAPEV+ + A
Sbjct: 136 HSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSA 195
Query: 454 YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNR 513
Y K DIWSLGI AIE+ +GEPP + +P+R L+LI N P L + F++F++
Sbjct: 196 YDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGD--FTKSFKEFIDA 253
Query: 514 CLEMDVDRRGSAKELLQHPFL-KLAKPLSSLTPLI 547
CL D R +AKELL+H F+ K +K S LT LI
Sbjct: 254 CLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELI 288
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 238 bits (608), Expect = 8e-63
Identities = 126/272 (46%), Positives = 176/272 (64%), Gaps = 4/272 (1%)
Query: 278 DPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILVMRENK 336
DP++ +T+ EKIG+G+ G V+ +D T + VAIK ++L++ + + E I EI V+ +
Sbjct: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
Query: 337 NPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSN 396
+P + Y SYL +LW++MEYL GGS D++ +DE QIA + RE L+ LD+LHS
Sbjct: 79 SPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSE 138
Query: 397 QVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGP 456
+ IHRDIK+ N+LL G VKL DFG Q+T Q KR+T VGTP+WMAPEV+ + AY
Sbjct: 139 KKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDS 198
Query: 457 KVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLE 516
K DIWSLGI AIE+ GEPP+ +P++ L+LI N P L+ S ++F+ CL
Sbjct: 199 KADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEG--NYSKPLKEFVEACLN 256
Query: 517 MDVDRRGSAKELLQHPF-LKLAKPLSSLTPLI 547
+ R +AKELL+H F L+ AK S LT LI
Sbjct: 257 KEPSFRPTAKELLKHKFILRNAKKTSYLTELI 288
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 238 bits (608), Expect = 8e-63
Identities = 126/272 (46%), Positives = 176/272 (64%), Gaps = 4/272 (1%)
Query: 278 DPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILVMRENK 336
DP++ +T+ EKIG+G+ G V+ +D T + VAIK ++L++ + + E I EI V+ +
Sbjct: 31 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 90
Query: 337 NPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSN 396
+P + Y SYL +LW++MEYL GGS D++ +DE QIA + RE L+ LD+LHS
Sbjct: 91 SPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSE 150
Query: 397 QVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGP 456
+ IHRDIK+ N+LL G VKL DFG Q+T Q KR+T VGTP+WMAPEV+ + AY
Sbjct: 151 KKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDS 210
Query: 457 KVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLE 516
K DIWSLGI AIE+ GEPP+ +P++ L+LI N P L+ S ++F+ CL
Sbjct: 211 KADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEG--NYSKPLKEFVEACLN 268
Query: 517 MDVDRRGSAKELLQHPF-LKLAKPLSSLTPLI 547
+ R +AKELL+H F L+ AK S LT LI
Sbjct: 269 KEPSFRPTAKELLKHKFILRNAKKTSYLTELI 300
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 236 bits (602), Expect = 4e-62
Identities = 125/272 (45%), Positives = 176/272 (64%), Gaps = 4/272 (1%)
Query: 278 DPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILVMRENK 336
DP++ +T+ ++IG+G+ G VY +D T + VAIK ++L++ + + E I EI V+ +
Sbjct: 15 DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74
Query: 337 NPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSN 396
+P I Y SYL +LW++MEYL GGS D++ ++E IA + RE L+ LD+LHS
Sbjct: 75 SPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSE 134
Query: 397 QVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGP 456
+ IHRDIK+ N+LL G VKL DFG Q+T Q KR+T VGTP+WMAPEV+ + AY
Sbjct: 135 RKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDF 194
Query: 457 KVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLE 516
K DIWSLGI AIE+ +GEPP + +P+R L+LI N P L+ S F++F+ CL
Sbjct: 195 KADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH--SKPFKEFVEACLN 252
Query: 517 MDVDRRGSAKELLQHPFL-KLAKPLSSLTPLI 547
D R +AKELL+H F+ + K S LT LI
Sbjct: 253 KDPRFRPTAKELLKHKFITRYTKKTSFLTELI 284
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 214 bits (545), Expect = 2e-55
Identities = 118/285 (41%), Positives = 171/285 (60%), Gaps = 6/285 (2%)
Query: 274 VSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMR 333
VS+ DP+ ++ +++G G G VY A D T + A+K + L + EI ++R
Sbjct: 7 VSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILR 66
Query: 334 ENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALDF 392
E ++PN+V Y+ SYL D LW+ ME+ GGSL ++ T ++E QIA VCRE L+ L
Sbjct: 67 ECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHH 126
Query: 393 LHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEV--VT 450
LHS IHRDIK N+LL + G VKL DFG ++T +KR + +GTPYWMAPEV V
Sbjct: 127 LHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVE 186
Query: 451 RK-AYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNG--TPELQNPERLSAVF 507
RK Y D+W+LGI AIE+ E +PP + +P+RAL L++ + P+L++ R + F
Sbjct: 187 RKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNF 246
Query: 508 RDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLIIAAKE 552
FL L + +R +A++LLQHPF P + LT L+ A +
Sbjct: 247 HHFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLLDKASD 291
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 213 bits (541), Expect = 5e-55
Identities = 117/297 (39%), Positives = 176/297 (59%), Gaps = 9/297 (3%)
Query: 256 RKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN 315
RK K+ E+ ++ + +P+ + ++G GA G VY A + T A K ++
Sbjct: 7 RKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVID 66
Query: 316 LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTET--C 373
+ + + E + EI ++ +PNIV LD++ + LW+++E+ AGG++ V+ E
Sbjct: 67 TKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERP 126
Query: 374 MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSK 433
+ E QI VC++ L AL++LH N++IHRD+K+ NIL +DG +KL DFG A+ T +
Sbjct: 127 LTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQR 186
Query: 434 RSTMVGTPYWMAPEVV-----TRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYL 488
R + +GTPYWMAPEVV + Y K D+WSLGI IEM E EPP+ NP+R L
Sbjct: 187 RDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLK 246
Query: 489 IATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKL--AKPLSSL 543
IA + P L P R S+ F+DFL +CLE +VD R + +LLQHPF+ + KP+ L
Sbjct: 247 IAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIREL 303
Score = 30.0 bits (66), Expect = 5.8
Identities = 50/226 (22%), Positives = 86/226 (38%), Gaps = 34/226 (15%)
Query: 70 ISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQTSNITKLE--- 126
I+L ++ EH + E D QM KL + E +LQT ++ E
Sbjct: 457 ITLETNIEHNLK-------SEEEKDQEKQQMFENKLIKS-EEIKDTILQTVDLVSQETGE 508
Query: 127 QKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTASEPPLAPPVS 186
++ N QAV DS+ + + D + ++ S E A V+
Sbjct: 509 KEANIQAV-------DSEVGLTKEDTQEKLGEDDKTQKDVISNTSDVIGTCE---AADVA 558
Query: 187 EEEDEEEEEEEDENEPP------------PVIAPRPEHTKSIYTRSVVESIASPAVPNKE 234
++ DE+ E+ N+ P++ P TK + + +VE NKE
Sbjct: 559 QKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEVPIKEIVEMNEIEEGKNKE 618
Query: 235 VTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPK 280
S+EN T + ++ + E +E +RS+V+ D K
Sbjct: 619 QAINSSENIMDINEEPGTTEGEEITESSSTEEME-VRSVVADTDQK 663
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 206 bits (525), Expect = 3e-53
Identities = 115/263 (43%), Positives = 166/263 (63%), Gaps = 6/263 (2%)
Query: 278 DPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKN 337
+P++ + ++IG G G VY A ++ TG+ AIK + L+ ++ EI++M++ K+
Sbjct: 11 NPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKH 70
Query: 338 PNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALDFLHSN 396
PNIV Y SYL D+LW+ ME+ GGSL D+ T + E QIA V RE LQ L +LHS
Sbjct: 71 PNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSK 130
Query: 397 QVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEV--VTRK-A 453
+HRDIK NILL +G VKL DFG AQIT +KR + +GTPYWMAPEV V RK
Sbjct: 131 GKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGG 190
Query: 454 YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNG--TPELQNPERLSAVFRDFL 511
Y D+W++GI AIE+ E +PP + +P+RAL+L+ + P+L++ + S F F+
Sbjct: 191 YNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFV 250
Query: 512 NRCLEMDVDRRGSAKELLQHPFL 534
L + +R +A++LLQHPF+
Sbjct: 251 KMALTKNPKKRPTAEKLLQHPFV 273
>gi|145275208 myosin IIIA [Homo sapiens]
Length = 1616
Score = 203 bits (517), Expect = 3e-52
Identities = 109/272 (40%), Positives = 161/272 (59%), Gaps = 15/272 (5%)
Query: 278 DPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKN 337
DP + E IG+G G V+ L+ GQ+ A+K ++ +E+ ++ + +
Sbjct: 16 DPSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDEEIEAEYNILKALSDH 75
Query: 338 PNIVNYLDSYLV-----GDELWVVMEYLAGGSLTDVVTETC-----MDEGQIAAVCRECL 387
PN+V + Y GD+LW+V+E +GGS+TD+V M E IA + E L
Sbjct: 76 PNVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEAL 135
Query: 388 QALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPE 447
L LH+N+ IHRD+K +NILL +G VKL DFG AQ+T + +R+T VGTP+WMAPE
Sbjct: 136 MGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPE 195
Query: 448 VVTRK-----AYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPER 502
V+ + Y + D WSLGI AIE+ +G+PP + +P+RAL+ I N P+L+ PE
Sbjct: 196 VIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPEL 255
Query: 503 LSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL 534
SA F DF+++CL D ++R + ELLQH F+
Sbjct: 256 WSAEFNDFISKCLTKDYEKRPTVSELLQHKFI 287
>gi|45439370 TAO kinase 1 [Homo sapiens]
Length = 1001
Score = 202 bits (515), Expect = 5e-52
Identities = 122/286 (42%), Positives = 170/286 (59%), Gaps = 14/286 (4%)
Query: 278 DPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNL---QQQPKKELIINEILVMRE 334
DP+K +T +IG G+ G VY A D+ T + VAIK+M+ Q K + II E+ ++
Sbjct: 23 DPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQR 82
Query: 335 NKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDV--VTETCMDEGQIAAVCRECLQALDF 392
K+PN + Y YL W+VMEY G S +D+ V + + E +IAA+ LQ L +
Sbjct: 83 IKHPNSIEYKGCYLREHTAWLVMEYCLG-SASDLLEVHKKPLQEVEIAAITHGALQGLAY 141
Query: 393 LHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV--- 449
LHS+ +IHRDIK+ NILL G VKL DFG + +P S VGTPYWMAPEV+
Sbjct: 142 LHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPANS----FVGTPYWMAPEVILAM 197
Query: 450 TRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRD 509
Y KVD+WSLGI IE+ E +PP N N + ALY IA N +P LQ+ E S FR+
Sbjct: 198 DEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNE-WSDYFRN 256
Query: 510 FLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLIIAAKEAIK 555
F++ CL+ R +++ELL+H F+ +P + L LI K+A++
Sbjct: 257 FVDSCLQKIPQDRPTSEELLKHIFVLRERPETVLIDLIQRTKDAVR 302
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.130 0.371
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,252,059
Number of Sequences: 37866
Number of extensions: 1257200
Number of successful extensions: 18878
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 982
Number of HSP's successfully gapped in prelim test: 295
Number of HSP's that attempted gapping in prelim test: 10908
Number of HSP's gapped (non-prelim): 4360
length of query: 559
length of database: 18,247,518
effective HSP length: 107
effective length of query: 452
effective length of database: 14,195,856
effective search space: 6416526912
effective search space used: 6416526912
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.