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Search of human proteins with 189491757
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens]
(565 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens] 1127 0.0
gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens] 1117 0.0
gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens] 1081 0.0
gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens] 1075 0.0
gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens] 1075 0.0
gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens] 1075 0.0
gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens] 859 0.0
gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens] 818 0.0
gi|32483399 p21-activated kinase 2 [Homo sapiens] 781 0.0
gi|62422561 p21-activated kinase 4 isoform 2 [Homo sapiens] 347 2e-95
gi|62422563 p21-activated kinase 4 isoform 2 [Homo sapiens] 347 2e-95
gi|62422554 p21-activated kinase 4 isoform 1 [Homo sapiens] 319 4e-87
gi|62422557 p21-activated kinase 4 isoform 1 [Homo sapiens] 319 4e-87
gi|5031975 p21-activated kinase 4 isoform 1 [Homo sapiens] 319 4e-87
gi|29826329 p21-activated kinase 7 [Homo sapiens] 316 4e-86
gi|24308191 p21-activated kinase 7 [Homo sapiens] 316 4e-86
gi|191252782 p21-activated kinase 6 [Homo sapiens] 302 5e-82
gi|191252780 p21-activated kinase 6 [Homo sapiens] 302 5e-82
gi|9910476 p21-activated kinase 6 [Homo sapiens] 302 5e-82
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 244 2e-64
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 244 2e-64
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 239 4e-63
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 238 8e-63
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 238 8e-63
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 236 4e-62
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 214 2e-55
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 213 5e-55
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 206 4e-53
gi|145275208 myosin IIIA [Homo sapiens] 203 3e-52
gi|45439370 TAO kinase 1 [Homo sapiens] 202 5e-52
>gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens]
Length = 565
Score = 1127 bits (2915), Expect = 0.0
Identities = 565/565 (100%), Positives = 565/565 (100%)
Query: 1 MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN 60
MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN
Sbjct: 1 MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN 60
Query: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKMGIPEQWA 120
KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKMGIPEQWA
Sbjct: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKMGIPEQWA 120
Query: 121 RLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTK 180
RLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTK
Sbjct: 121 RLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTK 180
Query: 181 TASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKE 240
TASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKE
Sbjct: 181 TASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKE 240
Query: 241 VTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGAS 300
VTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGAS
Sbjct: 241 VTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGAS 300
Query: 301 GTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELW 360
GTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELW
Sbjct: 301 GTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELW 360
Query: 361 VVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDG 420
VVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDG
Sbjct: 361 VVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDG 420
Query: 421 SVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGE 480
SVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGE
Sbjct: 421 SVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGE 480
Query: 481 PPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL 540
PPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL
Sbjct: 481 PPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL 540
Query: 541 KLAKPLSSLTPLIIAAKEAIKNSSR 565
KLAKPLSSLTPLIIAAKEAIKNSSR
Sbjct: 541 KLAKPLSSLTPLIIAAKEAIKNSSR 565
>gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens]
Length = 580
Score = 1117 bits (2889), Expect = 0.0
Identities = 565/580 (97%), Positives = 565/580 (97%), Gaps = 15/580 (2%)
Query: 1 MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN 60
MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN
Sbjct: 1 MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN 60
Query: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKM------- 113
KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKM
Sbjct: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKMPDLYGSQ 120
Query: 114 --------GIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGD 165
GIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGD
Sbjct: 121 MCPGKLPEGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGD 180
Query: 166 KSAHGYIAAHPSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTR 225
KSAHGYIAAHPSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTR
Sbjct: 181 KSAHGYIAAHPSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTR 240
Query: 226 SVVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDP 285
SVVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDP
Sbjct: 241 SVVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDP 300
Query: 286 KKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPN 345
KKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPN
Sbjct: 301 KKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPN 360
Query: 346 IVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVI 405
IVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVI
Sbjct: 361 IVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVI 420
Query: 406 HRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVD 465
HRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVD
Sbjct: 421 HRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVD 480
Query: 466 IWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDV 525
IWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDV
Sbjct: 481 IWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDV 540
Query: 526 DRRGSAKELLQHPFLKLAKPLSSLTPLIIAAKEAIKNSSR 565
DRRGSAKELLQHPFLKLAKPLSSLTPLIIAAKEAIKNSSR
Sbjct: 541 DRRGSAKELLQHPFLKLAKPLSSLTPLIIAAKEAIKNSSR 580
>gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens]
Length = 559
Score = 1081 bits (2796), Expect = 0.0
Identities = 548/567 (96%), Positives = 549/567 (96%), Gaps = 10/567 (1%)
Query: 1 MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN 60
MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN
Sbjct: 1 MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN 60
Query: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKM--GIPEQ 118
KKKEKERPEISLPSDFEHTIHVGFDAVTGEFT P S GK+ GIPEQ
Sbjct: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFT--------PDLYGSQMCPGKLPEGIPEQ 112
Query: 119 WARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSS 178
WARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSS
Sbjct: 113 WARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSS 172
Query: 179 TKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPN 238
TKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPN
Sbjct: 173 TKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPN 232
Query: 239 KEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQG 298
KEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQG
Sbjct: 233 KEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQG 292
Query: 299 ASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDE 358
ASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDE
Sbjct: 293 ASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDE 352
Query: 359 LWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGM 418
LWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGM
Sbjct: 353 LWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGM 412
Query: 419 DGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVE 478
DGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVE
Sbjct: 413 DGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVE 472
Query: 479 GEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHP 538
GEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHP
Sbjct: 473 GEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHP 532
Query: 539 FLKLAKPLSSLTPLIIAAKEAIKNSSR 565
FLKLAKPLSSLTPLIIAAKEAIKNSSR
Sbjct: 533 FLKLAKPLSSLTPLIIAAKEAIKNSSR 559
>gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 1075 bits (2779), Expect = 0.0
Identities = 544/565 (96%), Positives = 544/565 (96%), Gaps = 21/565 (3%)
Query: 1 MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN 60
MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN
Sbjct: 1 MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN 60
Query: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKMGIPEQWA 120
KKKEKERPEISLPSDFEHTIHVGFDAVTGEFT GIPEQWA
Sbjct: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFT---------------------GIPEQWA 99
Query: 121 RLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTK 180
RLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTK
Sbjct: 100 RLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTK 159
Query: 181 TASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKE 240
TASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKE
Sbjct: 160 TASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKE 219
Query: 241 VTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGAS 300
VTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGAS
Sbjct: 220 VTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGAS 279
Query: 301 GTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELW 360
GTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELW
Sbjct: 280 GTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELW 339
Query: 361 VVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDG 420
VVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDG
Sbjct: 340 VVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDG 399
Query: 421 SVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGE 480
SVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGE
Sbjct: 400 SVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGE 459
Query: 481 PPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL 540
PPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL
Sbjct: 460 PPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL 519
Query: 541 KLAKPLSSLTPLIIAAKEAIKNSSR 565
KLAKPLSSLTPLIIAAKEAIKNSSR
Sbjct: 520 KLAKPLSSLTPLIIAAKEAIKNSSR 544
>gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 1075 bits (2779), Expect = 0.0
Identities = 544/565 (96%), Positives = 544/565 (96%), Gaps = 21/565 (3%)
Query: 1 MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN 60
MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN
Sbjct: 1 MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN 60
Query: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKMGIPEQWA 120
KKKEKERPEISLPSDFEHTIHVGFDAVTGEFT GIPEQWA
Sbjct: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFT---------------------GIPEQWA 99
Query: 121 RLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTK 180
RLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTK
Sbjct: 100 RLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTK 159
Query: 181 TASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKE 240
TASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKE
Sbjct: 160 TASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKE 219
Query: 241 VTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGAS 300
VTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGAS
Sbjct: 220 VTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGAS 279
Query: 301 GTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELW 360
GTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELW
Sbjct: 280 GTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELW 339
Query: 361 VVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDG 420
VVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDG
Sbjct: 340 VVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDG 399
Query: 421 SVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGE 480
SVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGE
Sbjct: 400 SVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGE 459
Query: 481 PPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL 540
PPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL
Sbjct: 460 PPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL 519
Query: 541 KLAKPLSSLTPLIIAAKEAIKNSSR 565
KLAKPLSSLTPLIIAAKEAIKNSSR
Sbjct: 520 KLAKPLSSLTPLIIAAKEAIKNSSR 544
>gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 1075 bits (2779), Expect = 0.0
Identities = 544/565 (96%), Positives = 544/565 (96%), Gaps = 21/565 (3%)
Query: 1 MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN 60
MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN
Sbjct: 1 MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN 60
Query: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKMGIPEQWA 120
KKKEKERPEISLPSDFEHTIHVGFDAVTGEFT GIPEQWA
Sbjct: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFT---------------------GIPEQWA 99
Query: 121 RLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTK 180
RLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTK
Sbjct: 100 RLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTK 159
Query: 181 TASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKE 240
TASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKE
Sbjct: 160 TASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKE 219
Query: 241 VTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGAS 300
VTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGAS
Sbjct: 220 VTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGAS 279
Query: 301 GTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELW 360
GTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELW
Sbjct: 280 GTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELW 339
Query: 361 VVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDG 420
VVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDG
Sbjct: 340 VVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDG 399
Query: 421 SVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGE 480
SVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGE
Sbjct: 400 SVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGE 459
Query: 481 PPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL 540
PPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL
Sbjct: 460 PPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL 519
Query: 541 KLAKPLSSLTPLIIAAKEAIKNSSR 565
KLAKPLSSLTPLIIAAKEAIKNSSR
Sbjct: 520 KLAKPLSSLTPLIIAAKEAIKNSSR 544
>gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens]
Length = 545
Score = 859 bits (2220), Expect = 0.0
Identities = 445/573 (77%), Positives = 489/573 (85%), Gaps = 42/573 (7%)
Query: 2 SDGLDNEEKPPAPPLRMNSN-----NRDSSALNHSSKPLPMAPEEKNKKARL-RSIFPGG 55
++GLD ++KPPAPP+R S ++D+ LNH SKPLP PEEK KK R RSI PG
Sbjct: 3 NNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPG- 61
Query: 56 GDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKMGI 115
DKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFT G+
Sbjct: 62 -DKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFT---------------------GM 99
Query: 116 PEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAH 175
PEQWARLLQTSNITK EQKKNPQAVLDVL+FY+SK+T N+QKYMSFT DKSA Y +++
Sbjct: 100 PEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFT--DKSAEDYNSSN 157
Query: 176 PSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPA 235
+ K SE P PPVSE+ED+++ D+ PPPVIAPRPEHTKS+YTRSV+E + P
Sbjct: 158 ALNVKAVSETPAVPPVSEDEDDDD----DDATPPPVIAPRPEHTKSVYTRSVIEPL--PV 211
Query: 236 VPNKEV-TPPSAENANSST----LYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYT 290
P ++V T P + N++T L RNT++Q+KK KM+DEEILEKLRSIVSVGDPKKKYT
Sbjct: 212 TPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYT 271
Query: 291 RFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYL 350
RFEKIGQGASGTVYTA+D+ATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYL
Sbjct: 272 RFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYL 331
Query: 351 DSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIK 410
DSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQAL+FLHSNQVIHRDIK
Sbjct: 332 DSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIK 391
Query: 411 SDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLG 470
SDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLG
Sbjct: 392 SDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLG 451
Query: 471 IMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGS 530
IMAIEM+EGEPPYLNENPLRALYLIATNGTPELQNPE+LSA+FRDFLNRCLEMDV++RGS
Sbjct: 452 IMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGS 511
Query: 531 AKELLQHPFLKLAKPLSSLTPLIIAAKEAIKNS 563
AKELLQH FLK+AKPLSSLTPLI AAKEA KN+
Sbjct: 512 AKELLQHQFLKIAKPLSSLTPLIAAAKEATKNN 544
>gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens]
Length = 553
Score = 818 bits (2112), Expect = 0.0
Identities = 423/546 (77%), Positives = 465/546 (85%), Gaps = 42/546 (7%)
Query: 2 SDGLDNEEKPPAPPLRMNSN-----NRDSSALNHSSKPLPMAPEEKNKKARL-RSIFPGG 55
++GLD ++KPPAPP+R S ++D+ LNH SKPLP PEEK KK R RSI PG
Sbjct: 3 NNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPG- 61
Query: 56 GDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKMGI 115
DKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFT G+
Sbjct: 62 -DKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFT---------------------GM 99
Query: 116 PEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAH 175
PEQWARLLQTSNITK EQKKNPQAVLDVL+FY+SK+T N+QKYMSFT DKSA Y +++
Sbjct: 100 PEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFT--DKSAEDYNSSN 157
Query: 176 PSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPA 235
+ K SE P PPVSE+ED+++ D+ PPPVIAPRPEHTKS+YTRSV+E + P
Sbjct: 158 ALNVKAVSETPAVPPVSEDEDDDD----DDATPPPVIAPRPEHTKSVYTRSVIEPL--PV 211
Query: 236 VPNKEV-TPPSAENANSST----LYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYT 290
P ++V T P + N++T L RNT++Q+KK KM+DEEILEKLRSIVSVGDPKKKYT
Sbjct: 212 TPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYT 271
Query: 291 RFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYL 350
RFEKIGQGASGTVYTA+D+ATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYL
Sbjct: 272 RFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYL 331
Query: 351 DSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIK 410
DSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQAL+FLHSNQVIHRDIK
Sbjct: 332 DSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIK 391
Query: 411 SDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLG 470
SDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLG
Sbjct: 392 SDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLG 451
Query: 471 IMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGS 530
IMAIEM+EGEPPYLNENPLRALYLIATNGTPELQNPE+LSA+FRDFLNRCLEMDV++RGS
Sbjct: 452 IMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGS 511
Query: 531 AKELLQ 536
AKELLQ
Sbjct: 512 AKELLQ 517
>gi|32483399 p21-activated kinase 2 [Homo sapiens]
Length = 524
Score = 781 bits (2016), Expect = 0.0
Identities = 407/568 (71%), Positives = 464/568 (81%), Gaps = 50/568 (8%)
Query: 1 MSDGLDNEEKPPAPPLRMNSN-----NRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGG 55
MSD + E+KPPAPP+RM+S +D + NHS KPLP PEEK + ++ SIF G
Sbjct: 1 MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRHKIISIF-SG 59
Query: 56 GDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKMGI 115
+K +KKKEKERPEIS PSDFEHTIHVGFDAVTGEFT G+
Sbjct: 60 TEKGSKKKEKERPEISPPSDFEHTIHVGFDAVTGEFT---------------------GM 98
Query: 116 PEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAH 175
PEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDS QKY+SFT +K G+ +
Sbjct: 99 PEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTV--KQKYLSFTPPEKD--GFPSGT 154
Query: 176 PSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPA 235
P+ +E P V+EEED++EE PPVIAPRP+HTKSIYTRSV++ + +P
Sbjct: 155 PALNAKGTEAPAV--VTEEEDDDEETA------PPVIAPRPDHTKSIYTRSVIDPVPAPV 206
Query: 236 VPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKI 295
+++ ++ D+Q+KK+KMTDEEI+EKLR+IVS+GDPKKKYTR+EKI
Sbjct: 207 -----------GDSHVDGAAKSLDKQKKKTKMTDEEIMEKLRTIVSIGDPKKKYTRYEKI 255
Query: 296 GQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLV 355
GQGASGTV+TA D+A GQEVAIKQ+NLQ+QPKKELIINEILVM+E KNPNIVN+LDSYLV
Sbjct: 256 GQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLV 315
Query: 356 GDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNIL 415
GDEL+VVMEYLAGGSLTDVVTETCMDE QIAAVCRECLQAL+FLH+NQVIHRDIKSDN+L
Sbjct: 316 GDELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVL 375
Query: 416 LGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIE 475
LGM+GSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIE
Sbjct: 376 LGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIE 435
Query: 476 MVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELL 535
MVEGEPPYLNENPLRALYLIATNGTPELQNPE+LS +FRDFLNRCLEMDV++RGSAKELL
Sbjct: 436 MVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELL 495
Query: 536 QHPFLKLAKPLSSLTPLIIAAKEAIKNS 563
QHPFLKLAKPLSSLTPLI+AAKEA+K++
Sbjct: 496 QHPFLKLAKPLSSLTPLIMAAKEAMKSN 523
>gi|62422561 p21-activated kinase 4 isoform 2 [Homo sapiens]
Length = 438
Score = 347 bits (890), Expect = 2e-95
Identities = 199/491 (40%), Positives = 280/491 (57%), Gaps = 62/491 (12%)
Query: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKMGIPEQWARL 122
K K+R EIS PS+FEH +H GFD +FT G+P QW L
Sbjct: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFT---------------------GLPRQWQSL 42
Query: 123 LQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTA 182
++ E + P+ ++D + + SA G A P S+ ++
Sbjct: 43 IE-------ESARRPKPLVDPACITSIQPGAPKGEPHDVAPNGPSAGGL--AIPQSSSSS 93
Query: 183 SEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVT 242
S PP + + PP P A+PAVP
Sbjct: 94 SRPPTRARGAPSPGVLGPHASEPQLAPPACTP-----------------AAPAVPG---- 132
Query: 243 PPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGT 302
PP + QR+ +++ E+ L+ +V GDP+ F KIG+G++G
Sbjct: 133 PPGPRSP-----------QREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGI 181
Query: 303 VYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVV 362
V A ++G+ VA+K+M+L++Q ++EL+ NE+++MR+ ++ N+V +SYLVGDELWVV
Sbjct: 182 VCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVV 241
Query: 363 MEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSV 422
ME+L GG+LTD+VT T M+E QIAAVC LQAL LH+ VIHRDIKSD+ILL DG V
Sbjct: 242 MEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRV 301
Query: 423 KLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPP 482
KL+DFGFCAQ++ E +R ++VGTPYWMAPE+++R YGP+VDIWSLGIM IEMV+GEPP
Sbjct: 302 KLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPP 361
Query: 483 YLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKL 542
Y NE PL+A+ +I N P L+N ++S + FL+R L D +R +A ELL+HPFL
Sbjct: 362 YFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAK 421
Query: 543 AKPLSSLTPLI 553
A P +S+ PL+
Sbjct: 422 AGPPASIVPLM 432
>gi|62422563 p21-activated kinase 4 isoform 2 [Homo sapiens]
Length = 438
Score = 347 bits (890), Expect = 2e-95
Identities = 199/491 (40%), Positives = 280/491 (57%), Gaps = 62/491 (12%)
Query: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKMGIPEQWARL 122
K K+R EIS PS+FEH +H GFD +FT G+P QW L
Sbjct: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFT---------------------GLPRQWQSL 42
Query: 123 LQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTA 182
++ E + P+ ++D + + SA G A P S+ ++
Sbjct: 43 IE-------ESARRPKPLVDPACITSIQPGAPKGEPHDVAPNGPSAGGL--AIPQSSSSS 93
Query: 183 SEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVT 242
S PP + + PP P A+PAVP
Sbjct: 94 SRPPTRARGAPSPGVLGPHASEPQLAPPACTP-----------------AAPAVPG---- 132
Query: 243 PPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGT 302
PP + QR+ +++ E+ L+ +V GDP+ F KIG+G++G
Sbjct: 133 PPGPRSP-----------QREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGI 181
Query: 303 VYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVV 362
V A ++G+ VA+K+M+L++Q ++EL+ NE+++MR+ ++ N+V +SYLVGDELWVV
Sbjct: 182 VCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVV 241
Query: 363 MEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSV 422
ME+L GG+LTD+VT T M+E QIAAVC LQAL LH+ VIHRDIKSD+ILL DG V
Sbjct: 242 MEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRV 301
Query: 423 KLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPP 482
KL+DFGFCAQ++ E +R ++VGTPYWMAPE+++R YGP+VDIWSLGIM IEMV+GEPP
Sbjct: 302 KLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPP 361
Query: 483 YLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKL 542
Y NE PL+A+ +I N P L+N ++S + FL+R L D +R +A ELL+HPFL
Sbjct: 362 YFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAK 421
Query: 543 AKPLSSLTPLI 553
A P +S+ PL+
Sbjct: 422 AGPPASIVPLM 432
>gi|62422554 p21-activated kinase 4 isoform 1 [Homo sapiens]
Length = 591
Score = 319 bits (818), Expect = 4e-87
Identities = 171/380 (45%), Positives = 239/380 (62%), Gaps = 32/380 (8%)
Query: 174 AHPSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIAS 233
A P S+ ++S PP + + PP P A+
Sbjct: 238 AIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTP-----------------AA 280
Query: 234 PAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFE 293
PAVP PP + QR+ +++ E+ L+ +V GDP+ F
Sbjct: 281 PAVPG----PPGPRSP-----------QREPQRVSHEQFRAALQLVVDPGDPRSYLDNFI 325
Query: 294 KIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSY 353
KIG+G++G V A ++G+ VA+K+M+L++Q ++EL+ NE+++MR+ ++ N+V +SY
Sbjct: 326 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSY 385
Query: 354 LVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDN 413
LVGDELWVVME+L GG+LTD+VT T M+E QIAAVC LQAL LH+ VIHRDIKSD+
Sbjct: 386 LVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDS 445
Query: 414 ILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMA 473
ILL DG VKL+DFGFCAQ++ E +R ++VGTPYWMAPE+++R YGP+VDIWSLGIM
Sbjct: 446 ILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMV 505
Query: 474 IEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKE 533
IEMV+GEPPY NE PL+A+ +I N P L+N ++S + FL+R L D +R +A E
Sbjct: 506 IEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAE 565
Query: 534 LLQHPFLKLAKPLSSLTPLI 553
LL+HPFL A P +S+ PL+
Sbjct: 566 LLKHPFLAKAGPPASIVPLM 585
Score = 42.4 bits (98), Expect = 0.001
Identities = 23/64 (35%), Positives = 30/64 (46%), Gaps = 21/64 (32%)
Query: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKMGIPEQWARL 122
K K+R EIS PS+FEH +H GFD +FT G+P QW L
Sbjct: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFT---------------------GLPRQWQSL 42
Query: 123 LQTS 126
++ S
Sbjct: 43 IEES 46
>gi|62422557 p21-activated kinase 4 isoform 1 [Homo sapiens]
Length = 591
Score = 319 bits (818), Expect = 4e-87
Identities = 171/380 (45%), Positives = 239/380 (62%), Gaps = 32/380 (8%)
Query: 174 AHPSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIAS 233
A P S+ ++S PP + + PP P A+
Sbjct: 238 AIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTP-----------------AA 280
Query: 234 PAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFE 293
PAVP PP + QR+ +++ E+ L+ +V GDP+ F
Sbjct: 281 PAVPG----PPGPRSP-----------QREPQRVSHEQFRAALQLVVDPGDPRSYLDNFI 325
Query: 294 KIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSY 353
KIG+G++G V A ++G+ VA+K+M+L++Q ++EL+ NE+++MR+ ++ N+V +SY
Sbjct: 326 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSY 385
Query: 354 LVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDN 413
LVGDELWVVME+L GG+LTD+VT T M+E QIAAVC LQAL LH+ VIHRDIKSD+
Sbjct: 386 LVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDS 445
Query: 414 ILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMA 473
ILL DG VKL+DFGFCAQ++ E +R ++VGTPYWMAPE+++R YGP+VDIWSLGIM
Sbjct: 446 ILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMV 505
Query: 474 IEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKE 533
IEMV+GEPPY NE PL+A+ +I N P L+N ++S + FL+R L D +R +A E
Sbjct: 506 IEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAE 565
Query: 534 LLQHPFLKLAKPLSSLTPLI 553
LL+HPFL A P +S+ PL+
Sbjct: 566 LLKHPFLAKAGPPASIVPLM 585
Score = 42.4 bits (98), Expect = 0.001
Identities = 23/64 (35%), Positives = 30/64 (46%), Gaps = 21/64 (32%)
Query: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKMGIPEQWARL 122
K K+R EIS PS+FEH +H GFD +FT G+P QW L
Sbjct: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFT---------------------GLPRQWQSL 42
Query: 123 LQTS 126
++ S
Sbjct: 43 IEES 46
>gi|5031975 p21-activated kinase 4 isoform 1 [Homo sapiens]
Length = 591
Score = 319 bits (818), Expect = 4e-87
Identities = 171/380 (45%), Positives = 239/380 (62%), Gaps = 32/380 (8%)
Query: 174 AHPSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIAS 233
A P S+ ++S PP + + PP P A+
Sbjct: 238 AIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTP-----------------AA 280
Query: 234 PAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFE 293
PAVP PP + QR+ +++ E+ L+ +V GDP+ F
Sbjct: 281 PAVPG----PPGPRSP-----------QREPQRVSHEQFRAALQLVVDPGDPRSYLDNFI 325
Query: 294 KIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSY 353
KIG+G++G V A ++G+ VA+K+M+L++Q ++EL+ NE+++MR+ ++ N+V +SY
Sbjct: 326 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSY 385
Query: 354 LVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDN 413
LVGDELWVVME+L GG+LTD+VT T M+E QIAAVC LQAL LH+ VIHRDIKSD+
Sbjct: 386 LVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDS 445
Query: 414 ILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMA 473
ILL DG VKL+DFGFCAQ++ E +R ++VGTPYWMAPE+++R YGP+VDIWSLGIM
Sbjct: 446 ILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMV 505
Query: 474 IEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKE 533
IEMV+GEPPY NE PL+A+ +I N P L+N ++S + FL+R L D +R +A E
Sbjct: 506 IEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAE 565
Query: 534 LLQHPFLKLAKPLSSLTPLI 553
LL+HPFL A P +S+ PL+
Sbjct: 566 LLKHPFLAKAGPPASIVPLM 585
Score = 42.4 bits (98), Expect = 0.001
Identities = 23/64 (35%), Positives = 30/64 (46%), Gaps = 21/64 (32%)
Query: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKMGIPEQWARL 122
K K+R EIS PS+FEH +H GFD +FT G+P QW L
Sbjct: 4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFT---------------------GLPRQWQSL 42
Query: 123 LQTS 126
++ S
Sbjct: 43 IEES 46
>gi|29826329 p21-activated kinase 7 [Homo sapiens]
Length = 719
Score = 316 bits (809), Expect = 4e-86
Identities = 152/292 (52%), Positives = 218/292 (74%)
Query: 262 RKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN 321
++ S+++ E+ L+ +VS GDP++ F KIG+G++G V A + TG++VA+K+M+
Sbjct: 422 QQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMD 481
Query: 322 LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMD 381
L++Q ++EL+ NE+++MR+ + N+V+ SYLVGDELWVVME+L GG+LTD+VT T M+
Sbjct: 482 LRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMN 541
Query: 382 EGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS 441
E QIA VC L+AL +LH+ VIHRDIKSD+ILL DG +KL+DFGFCAQ++ E KR
Sbjct: 542 EEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRK 601
Query: 442 TMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTP 501
++VGTPYWMAPEV++R YG +VDIWSLGIM IEM++GEPPY NE PL+A+ I + P
Sbjct: 602 SLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPP 661
Query: 502 ELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLI 553
+++ ++S+V R FL+ L + +R +A+ELL HPFLKLA P S + PL+
Sbjct: 662 RVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLM 713
Score = 40.0 bits (92), Expect = 0.006
Identities = 18/35 (51%), Positives = 24/35 (68%)
Query: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQ 97
K+K++ EIS PS+FEH +H GFD +FT P Q
Sbjct: 4 KKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQ 38
>gi|24308191 p21-activated kinase 7 [Homo sapiens]
Length = 719
Score = 316 bits (809), Expect = 4e-86
Identities = 152/292 (52%), Positives = 218/292 (74%)
Query: 262 RKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN 321
++ S+++ E+ L+ +VS GDP++ F KIG+G++G V A + TG++VA+K+M+
Sbjct: 422 QQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMD 481
Query: 322 LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMD 381
L++Q ++EL+ NE+++MR+ + N+V+ SYLVGDELWVVME+L GG+LTD+VT T M+
Sbjct: 482 LRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMN 541
Query: 382 EGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS 441
E QIA VC L+AL +LH+ VIHRDIKSD+ILL DG +KL+DFGFCAQ++ E KR
Sbjct: 542 EEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRK 601
Query: 442 TMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTP 501
++VGTPYWMAPEV++R YG +VDIWSLGIM IEM++GEPPY NE PL+A+ I + P
Sbjct: 602 SLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPP 661
Query: 502 ELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLI 553
+++ ++S+V R FL+ L + +R +A+ELL HPFLKLA P S + PL+
Sbjct: 662 RVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLM 713
Score = 40.0 bits (92), Expect = 0.006
Identities = 18/35 (51%), Positives = 24/35 (68%)
Query: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQ 97
K+K++ EIS PS+FEH +H GFD +FT P Q
Sbjct: 4 KKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQ 38
>gi|191252782 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 302 bits (774), Expect = 5e-82
Identities = 165/400 (41%), Positives = 243/400 (60%), Gaps = 20/400 (5%)
Query: 174 AHPSSTKTASEPPLAPPVSEEEDEEEE--------EEEDENEPPPVIAPRPEHTKSIYTR 225
A PSS+K P P S +++ + ++P +P S +
Sbjct: 272 APPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQK 331
Query: 226 SVVESIASPAVPNKEVTPPSAEN----ANSSTLYRNTDRQRKKSKM--------TDEEIL 273
S+ + A+ +P + S ++S LY D K + T E+
Sbjct: 332 SLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFK 391
Query: 274 EKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIIN 333
LR +V GDP+ + KIG+G++G V A + +G++VA+K M+L++Q ++EL+ N
Sbjct: 392 AALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFN 451
Query: 334 EILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECL 393
E+++MR+ ++ N+V SYLVG+ELWV+ME+L GG+LTD+V++ ++E QIA VC L
Sbjct: 452 EVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVL 511
Query: 394 QALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPE 453
QAL +LH+ VIHRDIKSD+ILL +DG VKL+DFGFCAQI+ + KR ++VGTPYWMAPE
Sbjct: 512 QALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPE 571
Query: 454 VVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVF 513
V++R Y +VDIWSLGIM IEMV+GEPPY +++P++A+ + + P+L+N ++S V
Sbjct: 572 VISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVL 631
Query: 514 RDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLI 553
RDFL R L D R +A+ELL HPFL L PLI
Sbjct: 632 RDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLI 671
Score = 45.8 bits (107), Expect = 1e-04
Identities = 22/65 (33%), Positives = 32/65 (49%), Gaps = 21/65 (32%)
Query: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKMGIPEQWA 120
+KK+K+RPEIS P +F+H +H FD G+F +G+P QW
Sbjct: 3 RKKKKKRPEISAPQNFQHRVHTSFDPKEGKF---------------------VGLPPQWQ 41
Query: 121 RLLQT 125
+L T
Sbjct: 42 NILDT 46
>gi|191252780 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 302 bits (774), Expect = 5e-82
Identities = 165/400 (41%), Positives = 243/400 (60%), Gaps = 20/400 (5%)
Query: 174 AHPSSTKTASEPPLAPPVSEEEDEEEE--------EEEDENEPPPVIAPRPEHTKSIYTR 225
A PSS+K P P S +++ + ++P +P S +
Sbjct: 272 APPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQK 331
Query: 226 SVVESIASPAVPNKEVTPPSAEN----ANSSTLYRNTDRQRKKSKM--------TDEEIL 273
S+ + A+ +P + S ++S LY D K + T E+
Sbjct: 332 SLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFK 391
Query: 274 EKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIIN 333
LR +V GDP+ + KIG+G++G V A + +G++VA+K M+L++Q ++EL+ N
Sbjct: 392 AALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFN 451
Query: 334 EILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECL 393
E+++MR+ ++ N+V SYLVG+ELWV+ME+L GG+LTD+V++ ++E QIA VC L
Sbjct: 452 EVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVL 511
Query: 394 QALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPE 453
QAL +LH+ VIHRDIKSD+ILL +DG VKL+DFGFCAQI+ + KR ++VGTPYWMAPE
Sbjct: 512 QALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPE 571
Query: 454 VVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVF 513
V++R Y +VDIWSLGIM IEMV+GEPPY +++P++A+ + + P+L+N ++S V
Sbjct: 572 VISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVL 631
Query: 514 RDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLI 553
RDFL R L D R +A+ELL HPFL L PLI
Sbjct: 632 RDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLI 671
Score = 45.8 bits (107), Expect = 1e-04
Identities = 22/65 (33%), Positives = 32/65 (49%), Gaps = 21/65 (32%)
Query: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKMGIPEQWA 120
+KK+K+RPEIS P +F+H +H FD G+F +G+P QW
Sbjct: 3 RKKKKKRPEISAPQNFQHRVHTSFDPKEGKF---------------------VGLPPQWQ 41
Query: 121 RLLQT 125
+L T
Sbjct: 42 NILDT 46
>gi|9910476 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 302 bits (774), Expect = 5e-82
Identities = 165/400 (41%), Positives = 243/400 (60%), Gaps = 20/400 (5%)
Query: 174 AHPSSTKTASEPPLAPPVSEEEDEEEE--------EEEDENEPPPVIAPRPEHTKSIYTR 225
A PSS+K P P S +++ + ++P +P S +
Sbjct: 272 APPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQK 331
Query: 226 SVVESIASPAVPNKEVTPPSAEN----ANSSTLYRNTDRQRKKSKM--------TDEEIL 273
S+ + A+ +P + S ++S LY D K + T E+
Sbjct: 332 SLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFK 391
Query: 274 EKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIIN 333
LR +V GDP+ + KIG+G++G V A + +G++VA+K M+L++Q ++EL+ N
Sbjct: 392 AALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFN 451
Query: 334 EILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECL 393
E+++MR+ ++ N+V SYLVG+ELWV+ME+L GG+LTD+V++ ++E QIA VC L
Sbjct: 452 EVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVL 511
Query: 394 QALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPE 453
QAL +LH+ VIHRDIKSD+ILL +DG VKL+DFGFCAQI+ + KR ++VGTPYWMAPE
Sbjct: 512 QALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPE 571
Query: 454 VVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVF 513
V++R Y +VDIWSLGIM IEMV+GEPPY +++P++A+ + + P+L+N ++S V
Sbjct: 572 VISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVL 631
Query: 514 RDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLI 553
RDFL R L D R +A+ELL HPFL L PLI
Sbjct: 632 RDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLI 671
Score = 45.8 bits (107), Expect = 1e-04
Identities = 22/65 (33%), Positives = 32/65 (49%), Gaps = 21/65 (32%)
Query: 61 KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKMGIPEQWA 120
+KK+K+RPEIS P +F+H +H FD G+F +G+P QW
Sbjct: 3 RKKKKKRPEISAPQNFQHRVHTSFDPKEGKF---------------------VGLPPQWQ 41
Query: 121 RLLQT 125
+L T
Sbjct: 42 NILDT 46
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 244 bits (623), Expect = 2e-64
Identities = 123/288 (42%), Positives = 185/288 (64%), Gaps = 4/288 (1%)
Query: 273 LEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELII 332
L+KL P++ + EK+G+G+ G+V+ A+ +GQ VAIKQ+ ++ ++ II
Sbjct: 11 LKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQE--II 68
Query: 333 NEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVT--ETCMDEGQIAAVCR 390
EI +M++ +P +V Y SY +LW+VMEY GS++D++ + E +IA + +
Sbjct: 69 KEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILK 128
Query: 391 ECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWM 450
L+ L++LH + IHRDIK+ NILL +G KL DFG Q+T +KR+T++GTP+WM
Sbjct: 129 STLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWM 188
Query: 451 APEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLS 510
APEV+ Y DIWSLGI +IEM EG+PPY + +P+RA+++I TN P + PE S
Sbjct: 189 APEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWS 248
Query: 511 AVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLIIAAKE 558
F DF+ +CL + ++R +A +LLQHPF+K AKP+S L LI A E
Sbjct: 249 DDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAME 296
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 244 bits (623), Expect = 2e-64
Identities = 126/299 (42%), Positives = 189/299 (63%), Gaps = 12/299 (4%)
Query: 262 RKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN 321
R++ K DE+ L K P++ + EK+G+G+ G+VY A+ TGQ VAIKQ+
Sbjct: 11 RRQLKKLDEDSLTK--------QPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVP 62
Query: 322 LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVT--ETC 379
++ ++ II EI +M++ +P++V Y SY +LW+VMEY GS++D++
Sbjct: 63 VESDLQE--IIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKT 120
Query: 380 MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSK 439
+ E +IA + + L+ L++LH + IHRDIK+ NILL +G KL DFG Q+T +K
Sbjct: 121 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK 180
Query: 440 RSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNG 499
R+T++GTP+WMAPEV+ Y DIWSLGI AIEM EG+PPY + +P+RA+++I TN
Sbjct: 181 RNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNP 240
Query: 500 TPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLIIAAKE 558
P + PE S F DF+ +CL ++R +A +LLQHPF++ AK +S L LI A +
Sbjct: 241 PPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMD 299
Score = 29.6 bits (65), Expect = 7.7
Identities = 19/115 (16%), Positives = 45/115 (39%), Gaps = 3/115 (2%)
Query: 194 EEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSAENANSST 253
++D+EE EEDE + ++ + ++ S + A+ + + + P +
Sbjct: 313 DQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDTLP---SQLGTMV 369
Query: 254 LYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALD 308
+ + + K DE + S + + K+K + G+ G + + D
Sbjct: 370 INAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQINSFGKSVPGPLKNSSD 424
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 239 bits (611), Expect = 4e-63
Identities = 126/275 (45%), Positives = 179/275 (65%), Gaps = 4/275 (1%)
Query: 281 SVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILVMR 339
++ DP++ +T+ E+IG+G+ G V+ +D T Q VAIK ++L++ + + E I EI V+
Sbjct: 16 NIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLS 75
Query: 340 ENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFL 399
+ + + Y SYL G +LW++MEYL GGS D++ DE QIA + +E L+ LD+L
Sbjct: 76 QCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYL 135
Query: 400 HSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA 459
HS + IHRDIK+ N+LL G VKL DFG Q+T Q KR+T VGTP+WMAPEV+ + A
Sbjct: 136 HSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSA 195
Query: 460 YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNR 519
Y K DIWSLGI AIE+ +GEPP + +P+R L+LI N P L + F++F++
Sbjct: 196 YDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGD--FTKSFKEFIDA 253
Query: 520 CLEMDVDRRGSAKELLQHPFL-KLAKPLSSLTPLI 553
CL D R +AKELL+H F+ K +K S LT LI
Sbjct: 254 CLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELI 288
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 238 bits (608), Expect = 8e-63
Identities = 126/272 (46%), Positives = 176/272 (64%), Gaps = 4/272 (1%)
Query: 284 DPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILVMRENK 342
DP++ +T+ EKIG+G+ G V+ +D T + VAIK ++L++ + + E I EI V+ +
Sbjct: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
Query: 343 NPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSN 402
+P + Y SYL +LW++MEYL GGS D++ +DE QIA + RE L+ LD+LHS
Sbjct: 79 SPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSE 138
Query: 403 QVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGP 462
+ IHRDIK+ N+LL G VKL DFG Q+T Q KR+T VGTP+WMAPEV+ + AY
Sbjct: 139 KKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDS 198
Query: 463 KVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLE 522
K DIWSLGI AIE+ GEPP+ +P++ L+LI N P L+ S ++F+ CL
Sbjct: 199 KADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEG--NYSKPLKEFVEACLN 256
Query: 523 MDVDRRGSAKELLQHPF-LKLAKPLSSLTPLI 553
+ R +AKELL+H F L+ AK S LT LI
Sbjct: 257 KEPSFRPTAKELLKHKFILRNAKKTSYLTELI 288
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 238 bits (608), Expect = 8e-63
Identities = 126/272 (46%), Positives = 176/272 (64%), Gaps = 4/272 (1%)
Query: 284 DPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILVMRENK 342
DP++ +T+ EKIG+G+ G V+ +D T + VAIK ++L++ + + E I EI V+ +
Sbjct: 31 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 90
Query: 343 NPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSN 402
+P + Y SYL +LW++MEYL GGS D++ +DE QIA + RE L+ LD+LHS
Sbjct: 91 SPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSE 150
Query: 403 QVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGP 462
+ IHRDIK+ N+LL G VKL DFG Q+T Q KR+T VGTP+WMAPEV+ + AY
Sbjct: 151 KKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDS 210
Query: 463 KVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLE 522
K DIWSLGI AIE+ GEPP+ +P++ L+LI N P L+ S ++F+ CL
Sbjct: 211 KADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEG--NYSKPLKEFVEACLN 268
Query: 523 MDVDRRGSAKELLQHPF-LKLAKPLSSLTPLI 553
+ R +AKELL+H F L+ AK S LT LI
Sbjct: 269 KEPSFRPTAKELLKHKFILRNAKKTSYLTELI 300
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 236 bits (602), Expect = 4e-62
Identities = 125/272 (45%), Positives = 176/272 (64%), Gaps = 4/272 (1%)
Query: 284 DPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILVMRENK 342
DP++ +T+ ++IG+G+ G VY +D T + VAIK ++L++ + + E I EI V+ +
Sbjct: 15 DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74
Query: 343 NPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSN 402
+P I Y SYL +LW++MEYL GGS D++ ++E IA + RE L+ LD+LHS
Sbjct: 75 SPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSE 134
Query: 403 QVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGP 462
+ IHRDIK+ N+LL G VKL DFG Q+T Q KR+T VGTP+WMAPEV+ + AY
Sbjct: 135 RKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDF 194
Query: 463 KVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLE 522
K DIWSLGI AIE+ +GEPP + +P+R L+LI N P L+ S F++F+ CL
Sbjct: 195 KADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH--SKPFKEFVEACLN 252
Query: 523 MDVDRRGSAKELLQHPFL-KLAKPLSSLTPLI 553
D R +AKELL+H F+ + K S LT LI
Sbjct: 253 KDPRFRPTAKELLKHKFITRYTKKTSFLTELI 284
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 214 bits (545), Expect = 2e-55
Identities = 118/285 (41%), Positives = 171/285 (60%), Gaps = 6/285 (2%)
Query: 280 VSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMR 339
VS+ DP+ ++ +++G G G VY A D T + A+K + L + EI ++R
Sbjct: 7 VSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILR 66
Query: 340 ENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALDF 398
E ++PN+V Y+ SYL D LW+ ME+ GGSL ++ T ++E QIA VCRE L+ L
Sbjct: 67 ECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHH 126
Query: 399 LHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEV--VT 456
LHS IHRDIK N+LL + G VKL DFG ++T +KR + +GTPYWMAPEV V
Sbjct: 127 LHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVE 186
Query: 457 RK-AYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNG--TPELQNPERLSAVF 513
RK Y D+W+LGI AIE+ E +PP + +P+RAL L++ + P+L++ R + F
Sbjct: 187 RKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNF 246
Query: 514 RDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLIIAAKE 558
FL L + +R +A++LLQHPF P + LT L+ A +
Sbjct: 247 HHFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLLDKASD 291
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 213 bits (541), Expect = 5e-55
Identities = 117/297 (39%), Positives = 176/297 (59%), Gaps = 9/297 (3%)
Query: 262 RKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN 321
RK K+ E+ ++ + +P+ + ++G GA G VY A + T A K ++
Sbjct: 7 RKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVID 66
Query: 322 LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTET--C 379
+ + + E + EI ++ +PNIV LD++ + LW+++E+ AGG++ V+ E
Sbjct: 67 TKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERP 126
Query: 380 MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSK 439
+ E QI VC++ L AL++LH N++IHRD+K+ NIL +DG +KL DFG A+ T +
Sbjct: 127 LTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQR 186
Query: 440 RSTMVGTPYWMAPEVV-----TRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYL 494
R + +GTPYWMAPEVV + Y K D+WSLGI IEM E EPP+ NP+R L
Sbjct: 187 RDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLK 246
Query: 495 IATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKL--AKPLSSL 549
IA + P L P R S+ F+DFL +CLE +VD R + +LLQHPF+ + KP+ L
Sbjct: 247 IAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIREL 303
Score = 30.0 bits (66), Expect = 5.9
Identities = 69/360 (19%), Positives = 128/360 (35%), Gaps = 85/360 (23%)
Query: 1 MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKT- 59
+ DG + +E+ N+ A +S L +A E++K ++ I +KT
Sbjct: 315 VEDGKEEDEEEET------ENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTE 368
Query: 60 -------------NKKKEKERPEISLPSDFEHTIHVGFDAVTG----------------- 89
N+K + PE ++ EH +A+T
Sbjct: 369 RSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKENEREKRP 428
Query: 90 EFTNSPFQTSRPVTVASSQSEGKMGIPEQWARLLQTSNIT-------KLEQKKNPQAVLD 142
+ N P + +S SEGK E + +NI + +Q+K
Sbjct: 429 KLENLPDTEDQETVDINSVSEGK----ENNIMITLETNIEHNLKSEEEKDQEKQQMFENK 484
Query: 143 VLKFYDSKETV-NNQKYMSFTSGDKSAH-GYIAAHPSSTKTASEPPL------------- 187
++K + K+T+ +S +G+K A+ + + TK ++ L
Sbjct: 485 LIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKDVISN 544
Query: 188 ---------APPVSEEEDEEEEEEEDENEPP------------PVIAPRPEHTKSIYTRS 226
A V+++ DE+ E+ N+ P++ P TK + +
Sbjct: 545 TSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEVPIKE 604
Query: 227 VVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPK 286
+VE NKE S+EN T + ++ + E +E +RS+V+ D K
Sbjct: 605 IVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEME-VRSVVADTDQK 663
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 206 bits (525), Expect = 4e-53
Identities = 115/263 (43%), Positives = 166/263 (63%), Gaps = 6/263 (2%)
Query: 284 DPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKN 343
+P++ + ++IG G G VY A ++ TG+ AIK + L+ ++ EI++M++ K+
Sbjct: 11 NPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKH 70
Query: 344 PNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALDFLHSN 402
PNIV Y SYL D+LW+ ME+ GGSL D+ T + E QIA V RE LQ L +LHS
Sbjct: 71 PNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSK 130
Query: 403 QVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEV--VTRK-A 459
+HRDIK NILL +G VKL DFG AQIT +KR + +GTPYWMAPEV V RK
Sbjct: 131 GKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGG 190
Query: 460 YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNG--TPELQNPERLSAVFRDFL 517
Y D+W++GI AIE+ E +PP + +P+RAL+L+ + P+L++ + S F F+
Sbjct: 191 YNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFV 250
Query: 518 NRCLEMDVDRRGSAKELLQHPFL 540
L + +R +A++LLQHPF+
Sbjct: 251 KMALTKNPKKRPTAEKLLQHPFV 273
>gi|145275208 myosin IIIA [Homo sapiens]
Length = 1616
Score = 203 bits (517), Expect = 3e-52
Identities = 109/272 (40%), Positives = 161/272 (59%), Gaps = 15/272 (5%)
Query: 284 DPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKN 343
DP + E IG+G G V+ L+ GQ+ A+K ++ +E+ ++ + +
Sbjct: 16 DPSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDEEIEAEYNILKALSDH 75
Query: 344 PNIVNYLDSYLV-----GDELWVVMEYLAGGSLTDVVTETC-----MDEGQIAAVCRECL 393
PN+V + Y GD+LW+V+E +GGS+TD+V M E IA + E L
Sbjct: 76 PNVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEAL 135
Query: 394 QALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPE 453
L LH+N+ IHRD+K +NILL +G VKL DFG AQ+T + +R+T VGTP+WMAPE
Sbjct: 136 MGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPE 195
Query: 454 VVTRK-----AYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPER 508
V+ + Y + D WSLGI AIE+ +G+PP + +P+RAL+ I N P+L+ PE
Sbjct: 196 VIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPEL 255
Query: 509 LSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL 540
SA F DF+++CL D ++R + ELLQH F+
Sbjct: 256 WSAEFNDFISKCLTKDYEKRPTVSELLQHKFI 287
>gi|45439370 TAO kinase 1 [Homo sapiens]
Length = 1001
Score = 202 bits (515), Expect = 5e-52
Identities = 122/286 (42%), Positives = 170/286 (59%), Gaps = 14/286 (4%)
Query: 284 DPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNL---QQQPKKELIINEILVMRE 340
DP+K +T +IG G+ G VY A D+ T + VAIK+M+ Q K + II E+ ++
Sbjct: 23 DPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQR 82
Query: 341 NKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDV--VTETCMDEGQIAAVCRECLQALDF 398
K+PN + Y YL W+VMEY G S +D+ V + + E +IAA+ LQ L +
Sbjct: 83 IKHPNSIEYKGCYLREHTAWLVMEYCLG-SASDLLEVHKKPLQEVEIAAITHGALQGLAY 141
Query: 399 LHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV--- 455
LHS+ +IHRDIK+ NILL G VKL DFG + +P S VGTPYWMAPEV+
Sbjct: 142 LHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPANS----FVGTPYWMAPEVILAM 197
Query: 456 TRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRD 515
Y KVD+WSLGI IE+ E +PP N N + ALY IA N +P LQ+ E S FR+
Sbjct: 198 DEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNE-WSDYFRN 256
Query: 516 FLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLIIAAKEAIK 561
F++ CL+ R +++ELL+H F+ +P + L LI K+A++
Sbjct: 257 FVDSCLQKIPQDRPTSEELLKHIFVLRERPETVLIDLIQRTKDAVR 302
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.129 0.365
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,004,298
Number of Sequences: 37866
Number of extensions: 1225574
Number of successful extensions: 18870
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 931
Number of HSP's successfully gapped in prelim test: 285
Number of HSP's that attempted gapping in prelim test: 11348
Number of HSP's gapped (non-prelim): 4092
length of query: 565
length of database: 18,247,518
effective HSP length: 108
effective length of query: 457
effective length of database: 14,157,990
effective search space: 6470201430
effective search space used: 6470201430
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.