Guide to the Human Genome
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Search of human proteins with 18765758

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation
regulated kinase 1A isoform 1 [Homo sapiens]
         (763 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regula...  1571   0.0  
gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regula...  1546   0.0  
gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regula...  1143   0.0  
gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regula...  1053   0.0  
gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regula...  1048   0.0  
gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulat...   757   0.0  
gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulat...   696   0.0  
gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulat...   677   0.0  
gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regula...   283   3e-76
gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation regul...   277   3e-74
gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulat...   277   3e-74
gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regula...   276   7e-74
gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regula...   276   7e-74
gi|164420691 homeodomain interacting protein kinase 2 isoform 2 ...   222   1e-57
gi|164420685 homeodomain interacting protein kinase 2 isoform 1 ...   222   1e-57
gi|38201640 homeodomain-interacting protein kinase 1 isoform 1 [...   221   2e-57
gi|38201638 homeodomain-interacting protein kinase 1 isoform 2 [...   221   2e-57
gi|114796630 homeodomain interacting protein kinase 3 isoform 2 ...   215   1e-55
gi|114796624 homeodomain interacting protein kinase 3 isoform 1 ...   215   1e-55
gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens]   200   5e-51
gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens]               172   1e-42
gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]                172   1e-42
gi|10190706 CDC-like kinase 4 [Homo sapiens]                          172   1e-42
gi|47717134 CDC-like kinase 2 [Homo sapiens]                          171   2e-42
gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens]               171   2e-42
gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens]               171   2e-42
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]      169   7e-42
gi|169171014 PREDICTED: similar to homeodomain interacting prote...   137   4e-32
gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens]             134   2e-31
gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens]              134   2e-31

>gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 1 [Homo sapiens]
          Length = 763

 Score = 1571 bits (4068), Expect = 0.0
 Identities = 763/763 (100%), Positives = 763/763 (100%)

Query: 1   MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD 60
           MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD
Sbjct: 1   MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD 60

Query: 61  QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ 120
           QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ
Sbjct: 61  QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ 120

Query: 121 QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV 180
           QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV
Sbjct: 121 QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV 180

Query: 181 EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM 240
           EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM
Sbjct: 181 EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM 240

Query: 241 LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR 300
           LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR
Sbjct: 241 LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR 300

Query: 301 SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL 360
           SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL
Sbjct: 301 SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL 360

Query: 361 FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT 420
           FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT
Sbjct: 361 FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT 420

Query: 421 RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 480
           RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK
Sbjct: 421 RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 480

Query: 481 KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGG 540
           KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGG
Sbjct: 481 KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGG 540

Query: 541 HFTAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHH 600
           HFTAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHH
Sbjct: 541 HFTAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHH 600

Query: 601 HHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSS 660
           HHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSS
Sbjct: 601 HHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSS 660

Query: 661 STTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTY 720
           STTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTY
Sbjct: 661 STTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTY 720

Query: 721 QFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS 763
           QFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS
Sbjct: 721 QFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS 763


>gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 2 [Homo sapiens]
          Length = 754

 Score = 1546 bits (4004), Expect = 0.0
 Identities = 754/763 (98%), Positives = 754/763 (98%), Gaps = 9/763 (1%)

Query: 1   MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD 60
           MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD
Sbjct: 1   MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD 60

Query: 61  QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ 120
           QIQQPLTNQ         RRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ
Sbjct: 61  QIQQPLTNQ---------RRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ 111

Query: 121 QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV 180
           QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV
Sbjct: 112 QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV 171

Query: 181 EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM 240
           EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM
Sbjct: 172 EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM 231

Query: 241 LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR 300
           LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR
Sbjct: 232 LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR 291

Query: 301 SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL 360
           SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL
Sbjct: 292 SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL 351

Query: 361 FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT 420
           FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT
Sbjct: 352 FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT 411

Query: 421 RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 480
           RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK
Sbjct: 412 RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 471

Query: 481 KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGG 540
           KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGG
Sbjct: 472 KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGG 531

Query: 541 HFTAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHH 600
           HFTAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHH
Sbjct: 532 HFTAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHH 591

Query: 601 HHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSS 660
           HHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSS
Sbjct: 592 HHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSS 651

Query: 661 STTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTY 720
           STTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTY
Sbjct: 652 STTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTY 711

Query: 721 QFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS 763
           QFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS
Sbjct: 712 QFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS 754


>gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 3 [Homo sapiens]
          Length = 584

 Score = 1143 bits (2957), Expect = 0.0
 Identities = 564/577 (97%), Positives = 564/577 (97%), Gaps = 6/577 (1%)

Query: 1   MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD 60
           MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD
Sbjct: 1   MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD 60

Query: 61  QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ 120
           QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ
Sbjct: 61  QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ 120

Query: 121 QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV 180
           QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV
Sbjct: 121 QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV 180

Query: 181 EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM 240
           EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM
Sbjct: 181 EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM 240

Query: 241 LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR 300
           LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR
Sbjct: 241 LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR 300

Query: 301 SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL 360
           SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL
Sbjct: 301 SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL 360

Query: 361 FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT 420
           FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT
Sbjct: 361 FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT 420

Query: 421 RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 480
           RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK
Sbjct: 421 RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 480

Query: 481 KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGG 540
           KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGG
Sbjct: 481 KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGG 540

Query: 541 HFTAAVQAMDCETHSPQVRQQF------PAPLGWSGT 571
           HFTAAVQAMDCETHSPQV          PA L WS T
Sbjct: 541 HFTAAVQAMDCETHSPQVSSHVVHLLVSPAILRWSST 577



 Score = 30.0 bits (66), Expect = 8.4
 Identities = 17/47 (36%), Positives = 28/47 (59%)

Query: 637 TNSSSTQDSMEVGHSHHSMTSLSSSTTSSSTSSSSTGNQGNQAYQNR 683
           +NS ST  +ME   S  + +S SSS+  SS +S+S   + +  +Q+R
Sbjct: 490 SNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHR 536


>gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 5 [Homo sapiens]
          Length = 529

 Score = 1053 bits (2724), Expect = 0.0
 Identities = 519/528 (98%), Positives = 522/528 (98%)

Query: 1   MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD 60
           MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD
Sbjct: 1   MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD 60

Query: 61  QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ 120
           QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ
Sbjct: 61  QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ 120

Query: 121 QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV 180
           QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV
Sbjct: 121 QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV 180

Query: 181 EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM 240
           EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM
Sbjct: 181 EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM 240

Query: 241 LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR 300
           LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR
Sbjct: 241 LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR 300

Query: 301 SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL 360
           SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL
Sbjct: 301 SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL 360

Query: 361 FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT 420
           FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT
Sbjct: 361 FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT 420

Query: 421 RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 480
           RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK
Sbjct: 421 RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 480

Query: 481 KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRAR 528
           KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSG S+ + +S   R
Sbjct: 481 KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGASAISCSSWLVR 528


>gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 4 [Homo sapiens]
          Length = 540

 Score = 1048 bits (2711), Expect = 0.0
 Identities = 515/515 (100%), Positives = 515/515 (100%)

Query: 1   MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD 60
           MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD
Sbjct: 1   MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD 60

Query: 61  QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ 120
           QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ
Sbjct: 61  QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ 120

Query: 121 QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV 180
           QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV
Sbjct: 121 QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV 180

Query: 181 EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM 240
           EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM
Sbjct: 181 EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM 240

Query: 241 LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR 300
           LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR
Sbjct: 241 LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR 300

Query: 301 SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL 360
           SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL
Sbjct: 301 SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL 360

Query: 361 FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT 420
           FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT
Sbjct: 361 FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT 420

Query: 421 RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 480
           RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK
Sbjct: 421 RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 480

Query: 481 KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSS 515
           KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSS
Sbjct: 481 KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSS 515


>gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1B isoform a [Homo sapiens]
          Length = 629

 Score =  757 bits (1955), Expect = 0.0
 Identities = 377/509 (74%), Positives = 431/509 (84%), Gaps = 10/509 (1%)

Query: 69  QVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSS 128
           QV+PD+ +L RR+P  FRD  +APLRKLSVDLIKTYKHINEVYYAKKKRR QQ    DSS
Sbjct: 21  QVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSS 80

Query: 129 HKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIK 188
           +KKE+KV N GYDDDN+DYIV++GE+W++RYEIDSLIGKGSFGQVVKAYD   QE VAIK
Sbjct: 81  NKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIK 140

Query: 189 IIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDL 248
           IIKNKKAFLNQAQIE+RLLELMN+HDTEMKYYIVHLKRHFMFRNHLCLVFE+LSYNLYDL
Sbjct: 141 IIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDL 200

Query: 249 LRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF 308
           LRNT+FRGVSLNLTRK AQQ+CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF
Sbjct: 201 LRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF 260

Query: 309 GSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVD 368
           GSSCQLGQRIYQYIQSRFYRSPEVLLG PYDLAIDMWSLGCILVEMHTGEPLFSG+NEVD
Sbjct: 261 GSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVD 320

Query: 369 QMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILG 428
           QMN+IVEVLGIPPA +LDQAPKARK+FE+LP G W L++TK+ +++Y+ PGTR+L  +LG
Sbjct: 321 QMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLG 380

Query: 429 VETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTN 488
           V+TGGPGGRRAGE GH+ ADYL+F+DL+LRML+Y+P  RI P  ALQH FF++TADE TN
Sbjct: 381 VQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATN 440

Query: 489 T---SNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAA 545
           T    +S STSPA   +  S +T+S+ SSSGGSSG+S+  R      + +R+ GG     
Sbjct: 441 TGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTY---RYSNRYCGG---PG 494

Query: 546 VQAMDCETHSPQVRQQFPAPLGWSGTEAP 574
               DCE +SPQV    P    W+G + P
Sbjct: 495 PPITDCEMNSPQVPPSQPL-RPWAGGDVP 522


>gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1B isoform c [Homo sapiens]
          Length = 601

 Score =  696 bits (1795), Expect = 0.0
 Identities = 356/509 (69%), Positives = 406/509 (79%), Gaps = 38/509 (7%)

Query: 69  QVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSS 128
           QV+PD+ +L RR+P  FRD  +APLRKLSVDLIKTYKHINEVYYAKKKRR QQ    DSS
Sbjct: 21  QVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSS 80

Query: 129 HKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIK 188
           +KKE+KV N GYDDDN+DYIV++GE+W++RYEIDSLIGKGSFGQVVKAYD   QE VAIK
Sbjct: 81  NKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIK 140

Query: 189 IIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDL 248
           IIKNKKAFLNQAQIE+RLLELMN+HDTEMKYYIVHLKRHFMFRNHLCLVFE+LSYNLYDL
Sbjct: 141 IIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDL 200

Query: 249 LRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF 308
           LRNT+FRGVSLNLTRK AQQ+CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF
Sbjct: 201 LRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF 260

Query: 309 GSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVD 368
           GSSCQLGQRIYQYIQSRFYRSPEVLLG PYDLAIDMWSLGCILVEMHTGEPLFSG+NEVD
Sbjct: 261 GSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVD 320

Query: 369 QMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILG 428
           QMN+IVEVLGIPPA +LDQAPKARK+FE+LP G W L++TK+ +++Y+ PGTR+L     
Sbjct: 321 QMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQ---- 376

Query: 429 VETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTN 488
                                   +DL+LRML+Y+P  RI P  ALQH FF++TADE TN
Sbjct: 377 ------------------------EDLVLRMLEYEPAARISPLGALQHGFFRRTADEATN 412

Query: 489 T---SNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAA 545
           T    +S STSPA   +  S +T+S+ SSSGGSSG+S+  R      + +R+ GG     
Sbjct: 413 TGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTY---RYSNRYCGG---PG 466

Query: 546 VQAMDCETHSPQVRQQFPAPLGWSGTEAP 574
               DCE +SPQV    P    W+G + P
Sbjct: 467 PPITDCEMNSPQVPPSQPL-RPWAGGDVP 494


>gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1B isoform b [Homo sapiens]
          Length = 589

 Score =  677 bits (1748), Expect = 0.0
 Identities = 351/509 (68%), Positives = 396/509 (77%), Gaps = 50/509 (9%)

Query: 69  QVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSS 128
           QV+PD+ +L RR+P  FRD  +APLRKLSVDLIKTYKHINEVYYAKKKRR QQ    DSS
Sbjct: 21  QVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSS 80

Query: 129 HKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIK 188
           +KKE+KV N GYDDDN+DYIV++GE+W++RYEIDSLIGKGSFGQVVKAYD   QE VAIK
Sbjct: 81  NKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIK 140

Query: 189 IIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDL 248
           IIKNKKAFLNQAQIE+RLLELMN+HDTEMKYYIVHLKRHFMFRNHLCLVFE+LSYNLYDL
Sbjct: 141 IIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDL 200

Query: 249 LRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF 308
           LRNT+FRGVSLNLTRK AQQ+CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF
Sbjct: 201 LRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF 260

Query: 309 GSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVD 368
           GSSCQLGQRIYQYIQSRFYRSPEVLLG PYDLAIDMWSLGCILVEMHTGEPLFSG+NEVD
Sbjct: 261 GSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVD 320

Query: 369 QMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILG 428
           QMN+IVEVLGIPPA +LDQAPKARK+FE+LP G W L++TK+ +                
Sbjct: 321 QMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELR---------------- 364

Query: 429 VETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTN 488
                                   KDL+LRML+Y+P  RI P  ALQH FF++TADE TN
Sbjct: 365 ------------------------KDLVLRMLEYEPAARISPLGALQHGFFRRTADEATN 400

Query: 489 T---SNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAA 545
           T    +S STSPA   +  S +T+S+ SSSGGSSG+S+  R      + +R+ GG     
Sbjct: 401 TGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTY---RYSNRYCGG---PG 454

Query: 546 VQAMDCETHSPQVRQQFPAPLGWSGTEAP 574
               DCE +SPQV    P    W+G + P
Sbjct: 455 PPITDCEMNSPQVPPSQPL-RPWAGGDVP 482


>gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 4 [Homo sapiens]
          Length = 520

 Score =  283 bits (725), Expect = 3e-76
 Identities = 166/436 (38%), Positives = 236/436 (54%), Gaps = 45/436 (10%)

Query: 134 KVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNK 193
           K     +DD++  Y+    +    RYE+   IGKGSFGQV K  D    E VA+KII+NK
Sbjct: 79  KFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNK 138

Query: 194 KAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTN 253
           K F  QA +E+++LE + K D +  Y +VH+K  F FRNH C+ FE+L  NLY+L++N N
Sbjct: 139 KRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNN 198

Query: 254 FRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQ 313
           F+G SL++ R+F   +   L  L+  +  IIHCDLKPENI+L    ++++K++DFGSSC 
Sbjct: 199 FQGFSLSIVRRFTLSVLKCLQMLSVEK--IIHCDLKPENIVLYQKGQASVKVIDFGSSCY 256

Query: 314 LGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKI 373
             Q++Y YIQSRFYRSPEV+LG PYD+AIDMWSLGCI  E++TG PLF G NEV+Q+  I
Sbjct: 257 EHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACI 316

Query: 374 VEVLGIPPAHILDQAPKARKFFEK--LPDGTWNLKKTKDGKREYKPPGTRKLHNILGVET 431
           +EVLG+PPA  +  A + + FF+    P    N +    GK+ Y  P ++ L  +L    
Sbjct: 317 MEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNR----GKKRY--PDSKDLTMVLKTYD 370

Query: 432 GGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTAD------- 484
                               F D + R L ++P  R+ P  AL+H++  ++ +       
Sbjct: 371 ------------------TSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRP 412

Query: 485 EGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTA 544
           +    SNS   S   +        SS  +       T    + +  PT   +HSG     
Sbjct: 413 QTLRKSNSFFPSETRKDKVQGCHHSSRKADEITKETTE---KTKDSPTKHVQHSG----- 464

Query: 545 AVQAMDCETHSPQVRQ 560
                DC  H     Q
Sbjct: 465 --DQQDCLQHGADTVQ 478


>gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation
           regulated kinase 2 isoform 2 [Homo sapiens]
          Length = 601

 Score =  277 bits (708), Expect = 3e-74
 Identities = 164/416 (39%), Positives = 228/416 (54%), Gaps = 31/416 (7%)

Query: 109 EVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKG 168
           E+Y+     + +QG     +        N GYDDD   Y+    +    RYE+  +IGKG
Sbjct: 180 EIYFLGLNAKKRQGMTGGPN--------NGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKG 231

Query: 169 SFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHF 228
           SFGQVVKAYD    + VA+K+++N+K F  QA  E+R+LE + K D +    ++H+  +F
Sbjct: 232 SFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENF 291

Query: 229 MFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDL 288
            FRNH+C+ FE+LS NLY+L++   F+G SL L RKFA  +   L   A  +  IIHCDL
Sbjct: 292 TFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLD--ALHKNRIIHCDL 349

Query: 289 KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLG 348
           KPENILL    RS IK++DFGSSC   QR+Y YIQSRFYR+PEV+LG  Y + IDMWSLG
Sbjct: 350 KPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLG 409

Query: 349 CILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTW-NLKK 407
           CIL E+ TG PL  G +E DQ+  ++E+LG+P   +LD + +A+ F        +  +  
Sbjct: 410 CILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTT 469

Query: 408 TKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTR 467
             DG        +R+     G   G P  R  G +     D L F D + + L++DP  R
Sbjct: 470 LSDGSVVLNGGRSRR-----GKLRGPPESREWGNALKGCDDPL-FLDFLKQCLEWDPAVR 523

Query: 468 IQPYYALQHSFFK--------------KTADEGTNTSNSVSTSPAMEQSQSSGTTS 509
           + P  AL+H + +              K   E T    S+S  P    S S   T+
Sbjct: 524 MTPGQALRHPWLRRRLPKPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTN 579


>gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 2 isoform 1 [Homo sapiens]
          Length = 528

 Score =  277 bits (708), Expect = 3e-74
 Identities = 164/416 (39%), Positives = 228/416 (54%), Gaps = 31/416 (7%)

Query: 109 EVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKG 168
           E+Y+     + +QG     +        N GYDDD   Y+    +    RYE+  +IGKG
Sbjct: 107 EIYFLGLNAKKRQGMTGGPN--------NGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKG 158

Query: 169 SFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHF 228
           SFGQVVKAYD    + VA+K+++N+K F  QA  E+R+LE + K D +    ++H+  +F
Sbjct: 159 SFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENF 218

Query: 229 MFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDL 288
            FRNH+C+ FE+LS NLY+L++   F+G SL L RKFA  +   L   A  +  IIHCDL
Sbjct: 219 TFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLD--ALHKNRIIHCDL 276

Query: 289 KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLG 348
           KPENILL    RS IK++DFGSSC   QR+Y YIQSRFYR+PEV+LG  Y + IDMWSLG
Sbjct: 277 KPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLG 336

Query: 349 CILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTW-NLKK 407
           CIL E+ TG PL  G +E DQ+  ++E+LG+P   +LD + +A+ F        +  +  
Sbjct: 337 CILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTT 396

Query: 408 TKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTR 467
             DG        +R+     G   G P  R  G +     D L F D + + L++DP  R
Sbjct: 397 LSDGSVVLNGGRSRR-----GKLRGPPESREWGNALKGCDDPL-FLDFLKQCLEWDPAVR 450

Query: 468 IQPYYALQHSFFK--------------KTADEGTNTSNSVSTSPAMEQSQSSGTTS 509
           + P  AL+H + +              K   E T    S+S  P    S S   T+
Sbjct: 451 MTPGQALRHPWLRRRLPKPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTN 506


>gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 3 isoform b [Homo sapiens]
          Length = 568

 Score =  276 bits (705), Expect = 7e-74
 Identities = 157/398 (39%), Positives = 230/398 (57%), Gaps = 11/398 (2%)

Query: 101 IKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVY----NDGYDDDNYDYIVKNGEKWM 156
           +K YKH    Y   +   + +      + KK   V     N GYDD +  YI    +   
Sbjct: 127 LKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLA 186

Query: 157 DRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE 216
            RYE+  +IGKGSFGQV + YD   +++VA+K+++N+K F  QA  E+R+LE + K D  
Sbjct: 187 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT 246

Query: 217 MKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFL 276
               ++H+   F FRNH+C+ FE+LS +LY+L++   F+G S+ L RKFAQ +  +L   
Sbjct: 247 GSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD-- 304

Query: 277 ATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGM 336
           A  +  IIHCDLKPENILL +  RS+ K++DFGSSC   Q++Y YIQSRFYR+PE++LG 
Sbjct: 305 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGS 364

Query: 337 PYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFE 396
            Y   ID+WS GCIL E+ TG+PLF G +E DQ+  ++E+LG+PP  +L+Q+ +A+ F  
Sbjct: 365 RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFIN 424

Query: 397 KLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLI 456
                 +    T+   R     G  +     G + G PG +  G +     DYL F + +
Sbjct: 425 SKGIPRYCSVTTQADGRVVLVGGRSR----RGKKRGPPGSKDWGTALKGCDDYL-FIEFL 479

Query: 457 LRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVS 494
            R L +DP  R+ P  AL+H +  K+      T + VS
Sbjct: 480 KRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVS 517


>gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 3 isoform a [Homo sapiens]
          Length = 588

 Score =  276 bits (705), Expect = 7e-74
 Identities = 157/398 (39%), Positives = 230/398 (57%), Gaps = 11/398 (2%)

Query: 101 IKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVY----NDGYDDDNYDYIVKNGEKWM 156
           +K YKH    Y   +   + +      + KK   V     N GYDD +  YI    +   
Sbjct: 147 LKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLA 206

Query: 157 DRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE 216
            RYE+  +IGKGSFGQV + YD   +++VA+K+++N+K F  QA  E+R+LE + K D  
Sbjct: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT 266

Query: 217 MKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFL 276
               ++H+   F FRNH+C+ FE+LS +LY+L++   F+G S+ L RKFAQ +  +L   
Sbjct: 267 GSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD-- 324

Query: 277 ATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGM 336
           A  +  IIHCDLKPENILL +  RS+ K++DFGSSC   Q++Y YIQSRFYR+PE++LG 
Sbjct: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGS 384

Query: 337 PYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFE 396
            Y   ID+WS GCIL E+ TG+PLF G +E DQ+  ++E+LG+PP  +L+Q+ +A+ F  
Sbjct: 385 RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFIN 444

Query: 397 KLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLI 456
                 +    T+   R     G  +     G + G PG +  G +     DYL F + +
Sbjct: 445 SKGIPRYCSVTTQADGRVVLVGGRSR----RGKKRGPPGSKDWGTALKGCDDYL-FIEFL 499

Query: 457 LRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVS 494
            R L +DP  R+ P  AL+H +  K+      T + VS
Sbjct: 500 KRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVS 537


>gi|164420691 homeodomain interacting protein kinase 2 isoform 2
           [Homo sapiens]
          Length = 1171

 Score =  222 bits (565), Expect = 1e-57
 Identities = 134/339 (39%), Positives = 187/339 (55%), Gaps = 22/339 (6%)

Query: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218
           YE+   +G+G+FGQVVK + R   E VAIKI+KN  ++  Q QIEV +L  ++    +  
Sbjct: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257

Query: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278
           Y  V     F  +NH CLVFEML  NLYD L+   F  + L   R   QQ+ TAL+ L +
Sbjct: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317

Query: 279 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 335
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 375

Query: 336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395
           +P+  AIDMWSLGC++ E+  G PL+ GA+E DQ+  I +  G+P  ++L    K  +FF
Sbjct: 376 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 435

Query: 396 EKLPDG---TWNLKKTKDGKRE--YKPPGTRK-LHNIL------GVETGGPGGRRAGESG 443
            +  D     W LK   D + E   K    RK + N L       + T   G     E  
Sbjct: 436 NRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEK- 494

Query: 444 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKT 482
              AD  +F DL+ +ML  D   RI P   L H F   T
Sbjct: 495 ---ADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMT 530



 Score = 30.8 bits (68), Expect = 4.9
 Identities = 67/291 (23%), Positives = 97/291 (33%), Gaps = 40/291 (13%)

Query: 442  SGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADE--GTNTSNSVSTSPAM 499
            +GH  A+    K  +      +P+T I P    Q S      D     NTS+    S + 
Sbjct: 915  AGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHH---SSSY 971

Query: 500  EQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQAMDCETHSPQVR 559
            +   SS  TS++  SSG SSG           T++ +  G HF                +
Sbjct: 972  KSKSSSNVTSTSGHSSGSSSGAI---------TYRQQRPGPHF----------------Q 1006

Query: 560  QQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHH 619
            QQ P  L  +     T  T  +H  Q+        Q      H NS  H   H H     
Sbjct: 1007 QQQPLNLSQAQQHITTDRT-GSHRRQQAYITPTMAQAPYSFPH-NSPSHGTVHPHLAAAA 1064

Query: 620  GQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSS--TTSSSTSSSSTGNQGN 677
                L  +     Y +P    ST      G   H + S  S+  T   +   +S  +Q  
Sbjct: 1065 AAAHLPTQPHLYTYTAPAALGST------GTVAHLVASQGSARHTVQHTAYPASIVHQVP 1118

Query: 678  QAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGP 728
             +   R + + T+   Q  A   + T  S     T   G+P      N  P
Sbjct: 1119 VSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYP 1169


>gi|164420685 homeodomain interacting protein kinase 2 isoform 1
           [Homo sapiens]
          Length = 1198

 Score =  222 bits (565), Expect = 1e-57
 Identities = 134/339 (39%), Positives = 187/339 (55%), Gaps = 22/339 (6%)

Query: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218
           YE+   +G+G+FGQVVK + R   E VAIKI+KN  ++  Q QIEV +L  ++    +  
Sbjct: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257

Query: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278
           Y  V     F  +NH CLVFEML  NLYD L+   F  + L   R   QQ+ TAL+ L +
Sbjct: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317

Query: 279 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 335
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 375

Query: 336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395
           +P+  AIDMWSLGC++ E+  G PL+ GA+E DQ+  I +  G+P  ++L    K  +FF
Sbjct: 376 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 435

Query: 396 EKLPDG---TWNLKKTKDGKRE--YKPPGTRK-LHNIL------GVETGGPGGRRAGESG 443
            +  D     W LK   D + E   K    RK + N L       + T   G     E  
Sbjct: 436 NRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEK- 494

Query: 444 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKT 482
              AD  +F DL+ +ML  D   RI P   L H F   T
Sbjct: 495 ---ADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMT 530



 Score = 30.8 bits (68), Expect = 4.9
 Identities = 67/291 (23%), Positives = 97/291 (33%), Gaps = 40/291 (13%)

Query: 442  SGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADE--GTNTSNSVSTSPAM 499
            +GH  A+    K  +      +P+T I P    Q S      D     NTS+    S + 
Sbjct: 942  AGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHH---SSSY 998

Query: 500  EQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQAMDCETHSPQVR 559
            +   SS  TS++  SSG SSG           T++ +  G HF                +
Sbjct: 999  KSKSSSNVTSTSGHSSGSSSGAI---------TYRQQRPGPHF----------------Q 1033

Query: 560  QQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHH 619
            QQ P  L  +     T  T  +H  Q+        Q      H NS  H   H H     
Sbjct: 1034 QQQPLNLSQAQQHITTDRT-GSHRRQQAYITPTMAQAPYSFPH-NSPSHGTVHPHLAAAA 1091

Query: 620  GQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSS--TTSSSTSSSSTGNQGN 677
                L  +     Y +P    ST      G   H + S  S+  T   +   +S  +Q  
Sbjct: 1092 AAAHLPTQPHLYTYTAPAALGST------GTVAHLVASQGSARHTVQHTAYPASIVHQVP 1145

Query: 678  QAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGP 728
             +   R + + T+   Q  A   + T  S     T   G+P      N  P
Sbjct: 1146 VSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYP 1196


>gi|38201640 homeodomain-interacting protein kinase 1 isoform 1
           [Homo sapiens]
          Length = 1210

 Score =  221 bits (564), Expect = 2e-57
 Identities = 131/339 (38%), Positives = 191/339 (56%), Gaps = 22/339 (6%)

Query: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218
           YE+   +G+G+FGQV K + R  +E VAIKI+KN  ++  Q QIEV +L  ++  + + +
Sbjct: 190 YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENAD-E 248

Query: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278
           Y  V     F  +NH CLVFEML  NLYD L+   F  + L   R   QQ+ TAL+ L +
Sbjct: 249 YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS 308

Query: 279 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 335
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 309 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 366

Query: 336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395
           +P+  AIDMWSLGC++ E+  G PL+ GA+E DQ+  I +  G+P  ++L    K  +FF
Sbjct: 367 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 426

Query: 396 EKLPD---GTWNLKKTKDGKRE--YKPPGTRK-LHNIL------GVETGGPGGRRAGESG 443
            + P+     W LK  ++ + E   K    RK + N L       + T   G     E  
Sbjct: 427 NRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEK- 485

Query: 444 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKT 482
              AD  ++ DL+ +ML  D   RI P   L H F   T
Sbjct: 486 ---ADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMT 521


>gi|38201638 homeodomain-interacting protein kinase 1 isoform 2
           [Homo sapiens]
          Length = 1075

 Score =  221 bits (564), Expect = 2e-57
 Identities = 131/339 (38%), Positives = 191/339 (56%), Gaps = 22/339 (6%)

Query: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218
           YE+   +G+G+FGQV K + R  +E VAIKI+KN  ++  Q QIEV +L  ++  + + +
Sbjct: 190 YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENAD-E 248

Query: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278
           Y  V     F  +NH CLVFEML  NLYD L+   F  + L   R   QQ+ TAL+ L +
Sbjct: 249 YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS 308

Query: 279 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 335
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 309 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 366

Query: 336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395
           +P+  AIDMWSLGC++ E+  G PL+ GA+E DQ+  I +  G+P  ++L    K  +FF
Sbjct: 367 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 426

Query: 396 EKLPD---GTWNLKKTKDGKRE--YKPPGTRK-LHNIL------GVETGGPGGRRAGESG 443
            + P+     W LK  ++ + E   K    RK + N L       + T   G     E  
Sbjct: 427 NRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEK- 485

Query: 444 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKT 482
              AD  ++ DL+ +ML  D   RI P   L H F   T
Sbjct: 486 ---ADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMT 521


>gi|114796630 homeodomain interacting protein kinase 3 isoform 2
           [Homo sapiens]
          Length = 1194

 Score =  215 bits (548), Expect = 1e-55
 Identities = 133/335 (39%), Positives = 188/335 (56%), Gaps = 22/335 (6%)

Query: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218
           YE+   +G+G+FGQVVK + R   E VAIKI+KN  ++  Q QIEV +L  ++  + + +
Sbjct: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENAD-E 255

Query: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278
           Y  V     F  RNH CLVFEML  NLYD L+   F  + L + R   QQ+ TAL  L +
Sbjct: 256 YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS 315

Query: 279 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 335
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 316 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILG 373

Query: 336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395
           +P+  AIDMWSLGC++ E+  G PL+ GA E DQ+  I +  G+P   +L+   K+ +FF
Sbjct: 374 LPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFF 433

Query: 396 EKLPD---GTWNLKKTKDGKRE--YKPPGTRK-----LHNILGVET--GGPGGRRAGESG 443
            K  D     W LK  ++ + E   K    RK     L ++  V T     G     E  
Sbjct: 434 CKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEK- 492

Query: 444 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSF 478
              AD  +F  L+ +ML  D   RI P   L H F
Sbjct: 493 ---ADRREFVSLLKKMLLIDADLRITPAETLNHPF 524


>gi|114796624 homeodomain interacting protein kinase 3 isoform 1
           [Homo sapiens]
          Length = 1215

 Score =  215 bits (548), Expect = 1e-55
 Identities = 133/335 (39%), Positives = 188/335 (56%), Gaps = 22/335 (6%)

Query: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218
           YE+   +G+G+FGQVVK + R   E VAIKI+KN  ++  Q QIEV +L  ++  + + +
Sbjct: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENAD-E 255

Query: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278
           Y  V     F  RNH CLVFEML  NLYD L+   F  + L + R   QQ+ TAL  L +
Sbjct: 256 YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS 315

Query: 279 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 335
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 316 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILG 373

Query: 336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395
           +P+  AIDMWSLGC++ E+  G PL+ GA E DQ+  I +  G+P   +L+   K+ +FF
Sbjct: 374 LPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFF 433

Query: 396 EKLPD---GTWNLKKTKDGKRE--YKPPGTRK-----LHNILGVET--GGPGGRRAGESG 443
            K  D     W LK  ++ + E   K    RK     L ++  V T     G     E  
Sbjct: 434 CKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEK- 492

Query: 444 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSF 478
              AD  +F  L+ +ML  D   RI P   L H F
Sbjct: 493 ---ADRREFVSLLKKMLLIDADLRITPAETLNHPF 524


>gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens]
          Length = 616

 Score =  200 bits (508), Expect = 5e-51
 Identities = 129/341 (37%), Positives = 183/341 (53%), Gaps = 22/341 (6%)

Query: 157 DRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE 216
           D Y+I  ++GKG+FG+V K + R   E VAIKI+KN        + E++LL  M   D E
Sbjct: 9   DCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPE 68

Query: 217 MKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFL 276
            + +++     F       LVFE+L  NL++  +  NF  +     R    Q+ TAL  L
Sbjct: 69  -EAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARL 127

Query: 277 ATPELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIY---QYIQSRFYRSPE 331
              EL+IIH DLKPENI+L +  R    +K++DFGS+    +  Y    YIQSRFYR+PE
Sbjct: 128 K--ELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPE 185

Query: 332 VLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKA 391
           +LLG+P+   +D+WSLGC++ E+H G PL+ G NE DQ+  I E  G+P  H+L  A KA
Sbjct: 186 ILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKA 245

Query: 392 RKFFEKLPD----GTWNLKKTKD--GKREYKPPGTRK-----LHNILGVETGGPGGRRAG 440
             FF++ P       W LK + D   + + +P   RK     L  I  V  G    R   
Sbjct: 246 HHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTF 305

Query: 441 ESGHTVADYLKFK---DLILRMLDYDPKTRIQPYYALQHSF 478
                +A++   K   +LI RML ++   RI P  AL+H F
Sbjct: 306 PDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPF 346


>gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens]
          Length = 526

 Score =  172 bits (435), Expect = 1e-42
 Identities = 116/395 (29%), Positives = 190/395 (48%), Gaps = 47/395 (11%)

Query: 103 TYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEID 162
           +YK  + ++++     H++  G     K+ R V     DD+    I ++G+    RYEI 
Sbjct: 154 SYKSKHRIHHSTS---HRRSHGKSHRRKRTRSVE----DDEEGHLICQSGDVLSARYEIV 206

Query: 163 SLIGKGSFGQVVKAYD-RVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYI 221
             +G+G+FG+VV+  D +     VA+KI+KN   +   A+ E+++LE +N  D    +  
Sbjct: 207 DTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRC 266

Query: 222 VHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPEL 281
           V +   F    H+C+VFE+L  + YD ++   F    L+  RK A Q+C ++ FL + +L
Sbjct: 267 VQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKL 326

Query: 282 SIIHCDLKPENILLC--------NPK---------RSAIKIVDFGSSCQLGQRIYQYIQS 324
           +  H DLKPENIL          NPK            IK+VDFGS+    +     + +
Sbjct: 327 T--HTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVST 384

Query: 325 RFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHI 384
           R YR+PEV+L + +    D+WS+GCIL+E + G  +F   +  + +  +  +LG  P H+
Sbjct: 385 RHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHM 444

Query: 385 LDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGH 444
           + +  K + F     D   +    +   R  KP     L   +                 
Sbjct: 445 IQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDV----------------- 487

Query: 445 TVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 479
              ++ +  DLI +ML+YDP  RI    AL+H FF
Sbjct: 488 ---EHERLFDLIQKMLEYDPAKRITLREALKHPFF 519


>gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]
          Length = 484

 Score =  172 bits (435), Expect = 1e-42
 Identities = 116/395 (29%), Positives = 190/395 (48%), Gaps = 47/395 (11%)

Query: 103 TYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEID 162
           +YK  + ++++     H++  G     K+ R V     DD+    I ++G+    RYEI 
Sbjct: 112 SYKSKHRIHHSTS---HRRSHGKSHRRKRTRSVE----DDEEGHLICQSGDVLSARYEIV 164

Query: 163 SLIGKGSFGQVVKAYD-RVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYI 221
             +G+G+FG+VV+  D +     VA+KI+KN   +   A+ E+++LE +N  D    +  
Sbjct: 165 DTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRC 224

Query: 222 VHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPEL 281
           V +   F    H+C+VFE+L  + YD ++   F    L+  RK A Q+C ++ FL + +L
Sbjct: 225 VQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKL 284

Query: 282 SIIHCDLKPENILLC--------NPK---------RSAIKIVDFGSSCQLGQRIYQYIQS 324
           +  H DLKPENIL          NPK            IK+VDFGS+    +     + +
Sbjct: 285 T--HTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVST 342

Query: 325 RFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHI 384
           R YR+PEV+L + +    D+WS+GCIL+E + G  +F   +  + +  +  +LG  P H+
Sbjct: 343 RHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHM 402

Query: 385 LDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGH 444
           + +  K + F     D   +    +   R  KP     L   +                 
Sbjct: 403 IQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDV----------------- 445

Query: 445 TVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 479
              ++ +  DLI +ML+YDP  RI    AL+H FF
Sbjct: 446 ---EHERLFDLIQKMLEYDPAKRITLREALKHPFF 477


>gi|10190706 CDC-like kinase 4 [Homo sapiens]
          Length = 481

 Score =  172 bits (435), Expect = 1e-42
 Identities = 112/385 (29%), Positives = 189/385 (49%), Gaps = 43/385 (11%)

Query: 115 KKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIV-KNGEKWMDRYEIDSLIGKGSFGQV 173
           K++R++      S  K  R+  +   +DD   +++ ++G+    RYEI   +G+G+FG+V
Sbjct: 114 KRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKV 173

Query: 174 VKAYDR-VEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRN 232
           V+  D  ++   VA+KI+KN   +   A+ E+++LE +N  D    +  V +   F    
Sbjct: 174 VECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHG 233

Query: 233 HLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPEN 292
           H+C+VFE+L  + YD ++  +F    ++  R+ A Q+C ++ FL   +L+  H DLKPEN
Sbjct: 234 HVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLT--HTDLKPEN 291

Query: 293 ILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLG 335
           IL                     K + IK+VDFGS+    +     + +R YR+PEV+L 
Sbjct: 292 ILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILA 351

Query: 336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395
           + +    D+WS+GCIL+E + G  +F   +  + +  +  +LG  P H++ +  K + F 
Sbjct: 352 LGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFH 411

Query: 396 EKLPDGTWNLKKTKDGKREYKPPGTRKL-HNILGVETGGPGGRRAGESGHTVADYLKFKD 454
               D   +    +  +R  KP     L H+                      ++ K  D
Sbjct: 412 HNQLDWDEHSSAGRYVRRRCKPLKEFMLCHD---------------------EEHEKLFD 450

Query: 455 LILRMLDYDPKTRIQPYYALQHSFF 479
           L+ RML+YDP  RI    ALQH FF
Sbjct: 451 LVRRMLEYDPTQRITLDEALQHPFF 475


>gi|47717134 CDC-like kinase 2 [Homo sapiens]
          Length = 498

 Score =  171 bits (434), Expect = 2e-42
 Identities = 117/394 (29%), Positives = 197/394 (50%), Gaps = 44/394 (11%)

Query: 114 KKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWM-DRYEIDSLIGKGSFGQ 172
           +++RR  +     SSH   R       +DD   +++ +   W+ +RYEI S +G+G+FG+
Sbjct: 119 RRRRRRSRTFSRSSSHSSRRA---KSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGR 175

Query: 173 VVKAYD-RVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFR 231
           VV+  D R     VA+KIIKN + +   A++E+ +LE +N+ D + K   V +   F + 
Sbjct: 176 VVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYH 235

Query: 232 NHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPE 291
            H+C+ FE+L  + +D L++ N+    ++  R  A Q+C A+ FL   +L+  H DLKPE
Sbjct: 236 GHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLT--HTDLKPE 293

Query: 292 NILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLL 334
           NIL  N                  K +A+++VDFGS+    +     + +R YR+PEV+L
Sbjct: 294 NILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVIL 353

Query: 335 GMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKF 394
            + +    D+WS+GCI+ E + G  LF   +  + +  +  +LG  P+ ++ +  K + F
Sbjct: 354 ELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYF 413

Query: 395 FEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKD 454
           +    D  W+ + T  G+  Y     + L   L  E                 ++ +  D
Sbjct: 414 YRGRLD--WD-ENTSAGR--YVRENCKPLRRYLTSE---------------AEEHHQLFD 453

Query: 455 LILRMLDYDPKTRIQPYYALQHSFFKKTADEGTN 488
           LI  ML+Y+P  R+    ALQH FF +   E  N
Sbjct: 454 LIESMLEYEPAKRLTLGEALQHPFFARLRAEPPN 487


>gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens]
          Length = 638

 Score =  171 bits (434), Expect = 2e-42
 Identities = 114/397 (28%), Positives = 191/397 (48%), Gaps = 46/397 (11%)

Query: 104 YKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDS 163
           Y+     ++  K+R          S +  ++      DD     + + G+   +RYEI  
Sbjct: 249 YRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVG 308

Query: 164 LIGKGSFGQVVKAYDRVE-QEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIV 222
            +G+G+FG+VV+  D    +  VA+KII+N   +   A++E+ +L+ + + D E K+  V
Sbjct: 309 NLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCV 368

Query: 223 HLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELS 282
            +   F F  H+C+ FE+L  N ++ L+  NF+   L   R  A Q+C AL FL   +L+
Sbjct: 369 LMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLT 428

Query: 283 IIHCDLKPENILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYIQSR 325
             H DLKPENIL  N                  K ++I++ DFGS+    +     + +R
Sbjct: 429 --HTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATR 486

Query: 326 FYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHIL 385
            YR PEV+L + +    D+WS+GCIL E + G  LF      + +  + ++LG  P+H++
Sbjct: 487 HYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMI 546

Query: 386 DQAPKARKFFEKLPDGTWNLKKTKDG---KREYKPPGTRKLHNILGVETGGPGGRRAGES 442
            +  K + F++      W+ + + DG   K   KP  +  L + L               
Sbjct: 547 HRTRKQKYFYK--GGLVWD-ENSSDGRYVKENCKPLKSYMLQDSL--------------- 588

Query: 443 GHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 479
                ++++  DL+ RML++DP  RI    AL H FF
Sbjct: 589 -----EHVQLFDLMRRMLEFDPAQRITLAEALLHPFF 620


>gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens]
          Length = 490

 Score =  171 bits (434), Expect = 2e-42
 Identities = 114/397 (28%), Positives = 191/397 (48%), Gaps = 46/397 (11%)

Query: 104 YKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDS 163
           Y+     ++  K+R          S +  ++      DD     + + G+   +RYEI  
Sbjct: 101 YRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVG 160

Query: 164 LIGKGSFGQVVKAYDRVE-QEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIV 222
            +G+G+FG+VV+  D    +  VA+KII+N   +   A++E+ +L+ + + D E K+  V
Sbjct: 161 NLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCV 220

Query: 223 HLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELS 282
            +   F F  H+C+ FE+L  N ++ L+  NF+   L   R  A Q+C AL FL   +L+
Sbjct: 221 LMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLT 280

Query: 283 IIHCDLKPENILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYIQSR 325
             H DLKPENIL  N                  K ++I++ DFGS+    +     + +R
Sbjct: 281 --HTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATR 338

Query: 326 FYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHIL 385
            YR PEV+L + +    D+WS+GCIL E + G  LF      + +  + ++LG  P+H++
Sbjct: 339 HYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMI 398

Query: 386 DQAPKARKFFEKLPDGTWNLKKTKDG---KREYKPPGTRKLHNILGVETGGPGGRRAGES 442
            +  K + F++      W+ + + DG   K   KP  +  L + L               
Sbjct: 399 HRTRKQKYFYK--GGLVWD-ENSSDGRYVKENCKPLKSYMLQDSL--------------- 440

Query: 443 GHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 479
                ++++  DL+ RML++DP  RI    AL H FF
Sbjct: 441 -----EHVQLFDLMRRMLEFDPAQRITLAEALLHPFF 472


>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
          Length = 1007

 Score =  169 bits (429), Expect = 7e-42
 Identities = 123/374 (32%), Positives = 191/374 (51%), Gaps = 15/374 (4%)

Query: 112  YAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFG 171
            Y    R    G G D    KE     D + D    Y V  GE    RY +    G+G F 
Sbjct: 643  YFDSARLRAAGIGKDF---KENPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFS 699

Query: 172  QVVKAYD--RVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFM 229
             VV+A D  R  QE VA+KII+N +        E+  L+ +N  D + K++ + L RHF 
Sbjct: 700  NVVRARDNARANQE-VAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFY 758

Query: 230  FRNHLCLVFEMLSYNLYDLLRNTNFR-GVSLNLTRKFAQQMCTALLFLATPELSIIHCDL 288
             + HLCLVFE LS NL ++L+      G+ +   R ++QQ+  AL  L     +I+H D+
Sbjct: 759  HKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLK--RCNILHADI 816

Query: 289  KPENILLCNPKRSAIKIVDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGMPYDLAIDMWSL 347
            KP+NIL+ N  ++ +K+ DFGS+  +    I  Y+ SRFYR+PE+++G  YD  IDMWS+
Sbjct: 817  KPDNILV-NESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSV 875

Query: 348  GCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKK 407
            GC L E++TG+ LF G      +   +++ G  P  ++ +     + F++  +  + ++ 
Sbjct: 876  GCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMY-IEV 934

Query: 408  TKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTR 467
             K  +RE K      ++    +     G +R  E        L  KDL+ ++L  DP  R
Sbjct: 935  DKVTERE-KVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQL--KDLLDQILMLDPAKR 991

Query: 468  IQPYYALQHSFFKK 481
            I    ALQH+F ++
Sbjct: 992  ISINQALQHAFIQE 1005


>gi|169171014 PREDICTED: similar to homeodomain interacting protein
           kinase 2 [Homo sapiens]
          Length = 460

 Score =  137 bits (345), Expect = 4e-32
 Identities = 75/173 (43%), Positives = 105/173 (60%), Gaps = 6/173 (3%)

Query: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218
           YE+   +G+G+FGQVVK + R   E VAIKI+KN  ++  Q QIEV +L  ++    +  
Sbjct: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257

Query: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278
           Y  V     F  +NH CLVFEML  NLYD L+   F  + L   R   QQ+ TAL+ L +
Sbjct: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317

Query: 279 PELSIIHCDLKPENILLCNPKRS--AIKIVDFGSSCQLGQRIYQ-YIQSRFYR 328
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR
Sbjct: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYR 368


>gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens]
          Length = 1030

 Score =  134 bits (338), Expect = 2e-31
 Identities = 82/231 (35%), Positives = 133/231 (57%), Gaps = 12/231 (5%)

Query: 156 MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDT 215
           M+++EI  ++G+G++G V+K   +   E VAIK  K+ +      +  +R L+++    T
Sbjct: 10  MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLR---T 66

Query: 216 EMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLF 275
             +  IV LK  F  R  L LVFE +  N+ +LL      GV     + +  Q+  A+ +
Sbjct: 67  LKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMP-NGVPPEKVKSYIYQLIKAIHW 125

Query: 276 LATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQ----RIYQYIQSRFYRSPE 331
               +  I+H D+KPEN+L+ +     +K+ DFG +  L +       +Y+ +R+YRSPE
Sbjct: 126 CHKND--IVHRDIKPENLLISH--NDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPE 181

Query: 332 VLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPA 382
           +LLG PY  ++DMWS+GCIL E+  G+PLF G +E+DQ+  I +VLG  P+
Sbjct: 182 LLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPS 232


>gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens]
          Length = 1030

 Score =  134 bits (338), Expect = 2e-31
 Identities = 82/231 (35%), Positives = 133/231 (57%), Gaps = 12/231 (5%)

Query: 156 MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDT 215
           M+++EI  ++G+G++G V+K   +   E VAIK  K+ +      +  +R L+++    T
Sbjct: 10  MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLR---T 66

Query: 216 EMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLF 275
             +  IV LK  F  R  L LVFE +  N+ +LL      GV     + +  Q+  A+ +
Sbjct: 67  LKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMP-NGVPPEKVKSYIYQLIKAIHW 125

Query: 276 LATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQ----RIYQYIQSRFYRSPE 331
               +  I+H D+KPEN+L+ +     +K+ DFG +  L +       +Y+ +R+YRSPE
Sbjct: 126 CHKND--IVHRDIKPENLLISH--NDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPE 181

Query: 332 VLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPA 382
           +LLG PY  ++DMWS+GCIL E+  G+PLF G +E+DQ+  I +VLG  P+
Sbjct: 182 LLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPS 232


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.130    0.387 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,090,820
Number of Sequences: 37866
Number of extensions: 1506762
Number of successful extensions: 16594
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 637
Number of HSP's successfully gapped in prelim test: 395
Number of HSP's that attempted gapping in prelim test: 8527
Number of HSP's gapped (non-prelim): 4243
length of query: 763
length of database: 18,247,518
effective HSP length: 110
effective length of query: 653
effective length of database: 14,082,258
effective search space: 9195714474
effective search space used: 9195714474
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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