BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A isoform 1 [Homo sapiens] (763 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regula... 1571 0.0 gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regula... 1546 0.0 gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regula... 1143 0.0 gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regula... 1053 0.0 gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regula... 1048 0.0 gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulat... 757 0.0 gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulat... 696 0.0 gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulat... 677 0.0 gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regula... 283 3e-76 gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation regul... 277 3e-74 gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulat... 277 3e-74 gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regula... 276 7e-74 gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regula... 276 7e-74 gi|164420691 homeodomain interacting protein kinase 2 isoform 2 ... 222 1e-57 gi|164420685 homeodomain interacting protein kinase 2 isoform 1 ... 222 1e-57 gi|38201640 homeodomain-interacting protein kinase 1 isoform 1 [... 221 2e-57 gi|38201638 homeodomain-interacting protein kinase 1 isoform 2 [... 221 2e-57 gi|114796630 homeodomain interacting protein kinase 3 isoform 2 ... 215 1e-55 gi|114796624 homeodomain interacting protein kinase 3 isoform 1 ... 215 1e-55 gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens] 200 5e-51 gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens] 172 1e-42 gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens] 172 1e-42 gi|10190706 CDC-like kinase 4 [Homo sapiens] 172 1e-42 gi|47717134 CDC-like kinase 2 [Homo sapiens] 171 2e-42 gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens] 171 2e-42 gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens] 171 2e-42 gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens] 169 7e-42 gi|169171014 PREDICTED: similar to homeodomain interacting prote... 137 4e-32 gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens] 134 2e-31 gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens] 134 2e-31 >gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A isoform 1 [Homo sapiens] Length = 763 Score = 1571 bits (4068), Expect = 0.0 Identities = 763/763 (100%), Positives = 763/763 (100%) Query: 1 MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD 60 MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD Sbjct: 1 MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD 60 Query: 61 QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ 120 QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ Sbjct: 61 QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ 120 Query: 121 QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV 180 QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV Sbjct: 121 QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV 180 Query: 181 EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM 240 EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM Sbjct: 181 EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM 240 Query: 241 LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR 300 LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR Sbjct: 241 LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR 300 Query: 301 SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL 360 SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL Sbjct: 301 SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL 360 Query: 361 FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT 420 FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT Sbjct: 361 FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT 420 Query: 421 RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 480 RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK Sbjct: 421 RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 480 Query: 481 KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGG 540 KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGG Sbjct: 481 KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGG 540 Query: 541 HFTAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHH 600 HFTAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHH Sbjct: 541 HFTAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHH 600 Query: 601 HHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSS 660 HHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSS Sbjct: 601 HHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSS 660 Query: 661 STTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTY 720 STTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTY Sbjct: 661 STTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTY 720 Query: 721 QFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS 763 QFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS Sbjct: 721 QFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS 763 >gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A isoform 2 [Homo sapiens] Length = 754 Score = 1546 bits (4004), Expect = 0.0 Identities = 754/763 (98%), Positives = 754/763 (98%), Gaps = 9/763 (1%) Query: 1 MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD 60 MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD Sbjct: 1 MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD 60 Query: 61 QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ 120 QIQQPLTNQ RRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ Sbjct: 61 QIQQPLTNQ---------RRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ 111 Query: 121 QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV 180 QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV Sbjct: 112 QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV 171 Query: 181 EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM 240 EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM Sbjct: 172 EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM 231 Query: 241 LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR 300 LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR Sbjct: 232 LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR 291 Query: 301 SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL 360 SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL Sbjct: 292 SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL 351 Query: 361 FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT 420 FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT Sbjct: 352 FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT 411 Query: 421 RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 480 RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK Sbjct: 412 RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 471 Query: 481 KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGG 540 KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGG Sbjct: 472 KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGG 531 Query: 541 HFTAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHH 600 HFTAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHH Sbjct: 532 HFTAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHH 591 Query: 601 HHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSS 660 HHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSS Sbjct: 592 HHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSS 651 Query: 661 STTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTY 720 STTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTY Sbjct: 652 STTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTY 711 Query: 721 QFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS 763 QFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS Sbjct: 712 QFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS 754 >gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A isoform 3 [Homo sapiens] Length = 584 Score = 1143 bits (2957), Expect = 0.0 Identities = 564/577 (97%), Positives = 564/577 (97%), Gaps = 6/577 (1%) Query: 1 MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD 60 MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD Sbjct: 1 MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD 60 Query: 61 QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ 120 QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ Sbjct: 61 QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ 120 Query: 121 QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV 180 QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV Sbjct: 121 QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV 180 Query: 181 EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM 240 EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM Sbjct: 181 EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM 240 Query: 241 LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR 300 LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR Sbjct: 241 LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR 300 Query: 301 SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL 360 SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL Sbjct: 301 SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL 360 Query: 361 FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT 420 FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT Sbjct: 361 FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT 420 Query: 421 RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 480 RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK Sbjct: 421 RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 480 Query: 481 KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGG 540 KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGG Sbjct: 481 KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGG 540 Query: 541 HFTAAVQAMDCETHSPQVRQQF------PAPLGWSGT 571 HFTAAVQAMDCETHSPQV PA L WS T Sbjct: 541 HFTAAVQAMDCETHSPQVSSHVVHLLVSPAILRWSST 577 Score = 30.0 bits (66), Expect = 8.4 Identities = 17/47 (36%), Positives = 28/47 (59%) Query: 637 TNSSSTQDSMEVGHSHHSMTSLSSSTTSSSTSSSSTGNQGNQAYQNR 683 +NS ST +ME S + +S SSS+ SS +S+S + + +Q+R Sbjct: 490 SNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHR 536 >gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A isoform 5 [Homo sapiens] Length = 529 Score = 1053 bits (2724), Expect = 0.0 Identities = 519/528 (98%), Positives = 522/528 (98%) Query: 1 MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD 60 MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD Sbjct: 1 MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD 60 Query: 61 QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ 120 QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ Sbjct: 61 QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ 120 Query: 121 QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV 180 QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV Sbjct: 121 QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV 180 Query: 181 EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM 240 EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM Sbjct: 181 EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM 240 Query: 241 LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR 300 LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR Sbjct: 241 LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR 300 Query: 301 SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL 360 SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL Sbjct: 301 SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL 360 Query: 361 FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT 420 FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT Sbjct: 361 FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT 420 Query: 421 RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 480 RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK Sbjct: 421 RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 480 Query: 481 KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRAR 528 KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSG S+ + +S R Sbjct: 481 KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGASAISCSSWLVR 528 >gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A isoform 4 [Homo sapiens] Length = 540 Score = 1048 bits (2711), Expect = 0.0 Identities = 515/515 (100%), Positives = 515/515 (100%) Query: 1 MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD 60 MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD Sbjct: 1 MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD 60 Query: 61 QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ 120 QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ Sbjct: 61 QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ 120 Query: 121 QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV 180 QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV Sbjct: 121 QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV 180 Query: 181 EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM 240 EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM Sbjct: 181 EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM 240 Query: 241 LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR 300 LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR Sbjct: 241 LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR 300 Query: 301 SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL 360 SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL Sbjct: 301 SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL 360 Query: 361 FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT 420 FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT Sbjct: 361 FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT 420 Query: 421 RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 480 RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK Sbjct: 421 RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 480 Query: 481 KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSS 515 KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSS Sbjct: 481 KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSS 515 >gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B isoform a [Homo sapiens] Length = 629 Score = 757 bits (1955), Expect = 0.0 Identities = 377/509 (74%), Positives = 431/509 (84%), Gaps = 10/509 (1%) Query: 69 QVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSS 128 QV+PD+ +L RR+P FRD +APLRKLSVDLIKTYKHINEVYYAKKKRR QQ DSS Sbjct: 21 QVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSS 80 Query: 129 HKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIK 188 +KKE+KV N GYDDDN+DYIV++GE+W++RYEIDSLIGKGSFGQVVKAYD QE VAIK Sbjct: 81 NKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIK 140 Query: 189 IIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDL 248 IIKNKKAFLNQAQIE+RLLELMN+HDTEMKYYIVHLKRHFMFRNHLCLVFE+LSYNLYDL Sbjct: 141 IIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDL 200 Query: 249 LRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF 308 LRNT+FRGVSLNLTRK AQQ+CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF Sbjct: 201 LRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF 260 Query: 309 GSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVD 368 GSSCQLGQRIYQYIQSRFYRSPEVLLG PYDLAIDMWSLGCILVEMHTGEPLFSG+NEVD Sbjct: 261 GSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVD 320 Query: 369 QMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILG 428 QMN+IVEVLGIPPA +LDQAPKARK+FE+LP G W L++TK+ +++Y+ PGTR+L +LG Sbjct: 321 QMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLG 380 Query: 429 VETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTN 488 V+TGGPGGRRAGE GH+ ADYL+F+DL+LRML+Y+P RI P ALQH FF++TADE TN Sbjct: 381 VQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATN 440 Query: 489 T---SNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAA 545 T +S STSPA + S +T+S+ SSSGGSSG+S+ R + +R+ GG Sbjct: 441 TGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTY---RYSNRYCGG---PG 494 Query: 546 VQAMDCETHSPQVRQQFPAPLGWSGTEAP 574 DCE +SPQV P W+G + P Sbjct: 495 PPITDCEMNSPQVPPSQPL-RPWAGGDVP 522 >gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B isoform c [Homo sapiens] Length = 601 Score = 696 bits (1795), Expect = 0.0 Identities = 356/509 (69%), Positives = 406/509 (79%), Gaps = 38/509 (7%) Query: 69 QVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSS 128 QV+PD+ +L RR+P FRD +APLRKLSVDLIKTYKHINEVYYAKKKRR QQ DSS Sbjct: 21 QVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSS 80 Query: 129 HKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIK 188 +KKE+KV N GYDDDN+DYIV++GE+W++RYEIDSLIGKGSFGQVVKAYD QE VAIK Sbjct: 81 NKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIK 140 Query: 189 IIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDL 248 IIKNKKAFLNQAQIE+RLLELMN+HDTEMKYYIVHLKRHFMFRNHLCLVFE+LSYNLYDL Sbjct: 141 IIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDL 200 Query: 249 LRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF 308 LRNT+FRGVSLNLTRK AQQ+CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF Sbjct: 201 LRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF 260 Query: 309 GSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVD 368 GSSCQLGQRIYQYIQSRFYRSPEVLLG PYDLAIDMWSLGCILVEMHTGEPLFSG+NEVD Sbjct: 261 GSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVD 320 Query: 369 QMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILG 428 QMN+IVEVLGIPPA +LDQAPKARK+FE+LP G W L++TK+ +++Y+ PGTR+L Sbjct: 321 QMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQ---- 376 Query: 429 VETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTN 488 +DL+LRML+Y+P RI P ALQH FF++TADE TN Sbjct: 377 ------------------------EDLVLRMLEYEPAARISPLGALQHGFFRRTADEATN 412 Query: 489 T---SNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAA 545 T +S STSPA + S +T+S+ SSSGGSSG+S+ R + +R+ GG Sbjct: 413 TGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTY---RYSNRYCGG---PG 466 Query: 546 VQAMDCETHSPQVRQQFPAPLGWSGTEAP 574 DCE +SPQV P W+G + P Sbjct: 467 PPITDCEMNSPQVPPSQPL-RPWAGGDVP 494 >gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B isoform b [Homo sapiens] Length = 589 Score = 677 bits (1748), Expect = 0.0 Identities = 351/509 (68%), Positives = 396/509 (77%), Gaps = 50/509 (9%) Query: 69 QVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSS 128 QV+PD+ +L RR+P FRD +APLRKLSVDLIKTYKHINEVYYAKKKRR QQ DSS Sbjct: 21 QVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSS 80 Query: 129 HKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIK 188 +KKE+KV N GYDDDN+DYIV++GE+W++RYEIDSLIGKGSFGQVVKAYD QE VAIK Sbjct: 81 NKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIK 140 Query: 189 IIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDL 248 IIKNKKAFLNQAQIE+RLLELMN+HDTEMKYYIVHLKRHFMFRNHLCLVFE+LSYNLYDL Sbjct: 141 IIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDL 200 Query: 249 LRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF 308 LRNT+FRGVSLNLTRK AQQ+CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF Sbjct: 201 LRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF 260 Query: 309 GSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVD 368 GSSCQLGQRIYQYIQSRFYRSPEVLLG PYDLAIDMWSLGCILVEMHTGEPLFSG+NEVD Sbjct: 261 GSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVD 320 Query: 369 QMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILG 428 QMN+IVEVLGIPPA +LDQAPKARK+FE+LP G W L++TK+ + Sbjct: 321 QMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELR---------------- 364 Query: 429 VETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTN 488 KDL+LRML+Y+P RI P ALQH FF++TADE TN Sbjct: 365 ------------------------KDLVLRMLEYEPAARISPLGALQHGFFRRTADEATN 400 Query: 489 T---SNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAA 545 T +S STSPA + S +T+S+ SSSGGSSG+S+ R + +R+ GG Sbjct: 401 TGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTY---RYSNRYCGG---PG 454 Query: 546 VQAMDCETHSPQVRQQFPAPLGWSGTEAP 574 DCE +SPQV P W+G + P Sbjct: 455 PPITDCEMNSPQVPPSQPL-RPWAGGDVP 482 >gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 [Homo sapiens] Length = 520 Score = 283 bits (725), Expect = 3e-76 Identities = 166/436 (38%), Positives = 236/436 (54%), Gaps = 45/436 (10%) Query: 134 KVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNK 193 K +DD++ Y+ + RYE+ IGKGSFGQV K D E VA+KII+NK Sbjct: 79 KFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNK 138 Query: 194 KAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTN 253 K F QA +E+++LE + K D + Y +VH+K F FRNH C+ FE+L NLY+L++N N Sbjct: 139 KRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNN 198 Query: 254 FRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQ 313 F+G SL++ R+F + L L+ + IIHCDLKPENI+L ++++K++DFGSSC Sbjct: 199 FQGFSLSIVRRFTLSVLKCLQMLSVEK--IIHCDLKPENIVLYQKGQASVKVIDFGSSCY 256 Query: 314 LGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKI 373 Q++Y YIQSRFYRSPEV+LG PYD+AIDMWSLGCI E++TG PLF G NEV+Q+ I Sbjct: 257 EHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACI 316 Query: 374 VEVLGIPPAHILDQAPKARKFFEK--LPDGTWNLKKTKDGKREYKPPGTRKLHNILGVET 431 +EVLG+PPA + A + + FF+ P N + GK+ Y P ++ L +L Sbjct: 317 MEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNR----GKKRY--PDSKDLTMVLKTYD 370 Query: 432 GGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTAD------- 484 F D + R L ++P R+ P AL+H++ ++ + Sbjct: 371 ------------------TSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRP 412 Query: 485 EGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTA 544 + SNS S + SS + T + + PT +HSG Sbjct: 413 QTLRKSNSFFPSETRKDKVQGCHHSSRKADEITKETTE---KTKDSPTKHVQHSG----- 464 Query: 545 AVQAMDCETHSPQVRQ 560 DC H Q Sbjct: 465 --DQQDCLQHGADTVQ 478 >gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 isoform 2 [Homo sapiens] Length = 601 Score = 277 bits (708), Expect = 3e-74 Identities = 164/416 (39%), Positives = 228/416 (54%), Gaps = 31/416 (7%) Query: 109 EVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKG 168 E+Y+ + +QG + N GYDDD Y+ + RYE+ +IGKG Sbjct: 180 EIYFLGLNAKKRQGMTGGPN--------NGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKG 231 Query: 169 SFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHF 228 SFGQVVKAYD + VA+K+++N+K F QA E+R+LE + K D + ++H+ +F Sbjct: 232 SFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENF 291 Query: 229 MFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDL 288 FRNH+C+ FE+LS NLY+L++ F+G SL L RKFA + L A + IIHCDL Sbjct: 292 TFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLD--ALHKNRIIHCDL 349 Query: 289 KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLG 348 KPENILL RS IK++DFGSSC QR+Y YIQSRFYR+PEV+LG Y + IDMWSLG Sbjct: 350 KPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLG 409 Query: 349 CILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTW-NLKK 407 CIL E+ TG PL G +E DQ+ ++E+LG+P +LD + +A+ F + + Sbjct: 410 CILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTT 469 Query: 408 TKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTR 467 DG +R+ G G P R G + D L F D + + L++DP R Sbjct: 470 LSDGSVVLNGGRSRR-----GKLRGPPESREWGNALKGCDDPL-FLDFLKQCLEWDPAVR 523 Query: 468 IQPYYALQHSFFK--------------KTADEGTNTSNSVSTSPAMEQSQSSGTTS 509 + P AL+H + + K E T S+S P S S T+ Sbjct: 524 MTPGQALRHPWLRRRLPKPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTN 579 >gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 isoform 1 [Homo sapiens] Length = 528 Score = 277 bits (708), Expect = 3e-74 Identities = 164/416 (39%), Positives = 228/416 (54%), Gaps = 31/416 (7%) Query: 109 EVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKG 168 E+Y+ + +QG + N GYDDD Y+ + RYE+ +IGKG Sbjct: 107 EIYFLGLNAKKRQGMTGGPN--------NGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKG 158 Query: 169 SFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHF 228 SFGQVVKAYD + VA+K+++N+K F QA E+R+LE + K D + ++H+ +F Sbjct: 159 SFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENF 218 Query: 229 MFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDL 288 FRNH+C+ FE+LS NLY+L++ F+G SL L RKFA + L A + IIHCDL Sbjct: 219 TFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLD--ALHKNRIIHCDL 276 Query: 289 KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLG 348 KPENILL RS IK++DFGSSC QR+Y YIQSRFYR+PEV+LG Y + IDMWSLG Sbjct: 277 KPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLG 336 Query: 349 CILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTW-NLKK 407 CIL E+ TG PL G +E DQ+ ++E+LG+P +LD + +A+ F + + Sbjct: 337 CILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTT 396 Query: 408 TKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTR 467 DG +R+ G G P R G + D L F D + + L++DP R Sbjct: 397 LSDGSVVLNGGRSRR-----GKLRGPPESREWGNALKGCDDPL-FLDFLKQCLEWDPAVR 450 Query: 468 IQPYYALQHSFFK--------------KTADEGTNTSNSVSTSPAMEQSQSSGTTS 509 + P AL+H + + K E T S+S P S S T+ Sbjct: 451 MTPGQALRHPWLRRRLPKPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTN 506 >gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 isoform b [Homo sapiens] Length = 568 Score = 276 bits (705), Expect = 7e-74 Identities = 157/398 (39%), Positives = 230/398 (57%), Gaps = 11/398 (2%) Query: 101 IKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVY----NDGYDDDNYDYIVKNGEKWM 156 +K YKH Y + + + + KK V N GYDD + YI + Sbjct: 127 LKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLA 186 Query: 157 DRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE 216 RYE+ +IGKGSFGQV + YD +++VA+K+++N+K F QA E+R+LE + K D Sbjct: 187 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT 246 Query: 217 MKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFL 276 ++H+ F FRNH+C+ FE+LS +LY+L++ F+G S+ L RKFAQ + +L Sbjct: 247 GSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD-- 304 Query: 277 ATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGM 336 A + IIHCDLKPENILL + RS+ K++DFGSSC Q++Y YIQSRFYR+PE++LG Sbjct: 305 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGS 364 Query: 337 PYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFE 396 Y ID+WS GCIL E+ TG+PLF G +E DQ+ ++E+LG+PP +L+Q+ +A+ F Sbjct: 365 RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFIN 424 Query: 397 KLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLI 456 + T+ R G + G + G PG + G + DYL F + + Sbjct: 425 SKGIPRYCSVTTQADGRVVLVGGRSR----RGKKRGPPGSKDWGTALKGCDDYL-FIEFL 479 Query: 457 LRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVS 494 R L +DP R+ P AL+H + K+ T + VS Sbjct: 480 KRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVS 517 >gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 isoform a [Homo sapiens] Length = 588 Score = 276 bits (705), Expect = 7e-74 Identities = 157/398 (39%), Positives = 230/398 (57%), Gaps = 11/398 (2%) Query: 101 IKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVY----NDGYDDDNYDYIVKNGEKWM 156 +K YKH Y + + + + KK V N GYDD + YI + Sbjct: 147 LKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLA 206 Query: 157 DRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE 216 RYE+ +IGKGSFGQV + YD +++VA+K+++N+K F QA E+R+LE + K D Sbjct: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT 266 Query: 217 MKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFL 276 ++H+ F FRNH+C+ FE+LS +LY+L++ F+G S+ L RKFAQ + +L Sbjct: 267 GSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD-- 324 Query: 277 ATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGM 336 A + IIHCDLKPENILL + RS+ K++DFGSSC Q++Y YIQSRFYR+PE++LG Sbjct: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGS 384 Query: 337 PYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFE 396 Y ID+WS GCIL E+ TG+PLF G +E DQ+ ++E+LG+PP +L+Q+ +A+ F Sbjct: 385 RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFIN 444 Query: 397 KLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLI 456 + T+ R G + G + G PG + G + DYL F + + Sbjct: 445 SKGIPRYCSVTTQADGRVVLVGGRSR----RGKKRGPPGSKDWGTALKGCDDYL-FIEFL 499 Query: 457 LRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVS 494 R L +DP R+ P AL+H + K+ T + VS Sbjct: 500 KRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVS 537 >gi|164420691 homeodomain interacting protein kinase 2 isoform 2 [Homo sapiens] Length = 1171 Score = 222 bits (565), Expect = 1e-57 Identities = 134/339 (39%), Positives = 187/339 (55%), Gaps = 22/339 (6%) Query: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218 YE+ +G+G+FGQVVK + R E VAIKI+KN ++ Q QIEV +L ++ + Sbjct: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257 Query: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278 Y V F +NH CLVFEML NLYD L+ F + L R QQ+ TAL+ L + Sbjct: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317 Query: 279 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 335 L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR+PE++LG Sbjct: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 375 Query: 336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395 +P+ AIDMWSLGC++ E+ G PL+ GA+E DQ+ I + G+P ++L K +FF Sbjct: 376 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 435 Query: 396 EKLPDG---TWNLKKTKDGKRE--YKPPGTRK-LHNIL------GVETGGPGGRRAGESG 443 + D W LK D + E K RK + N L + T G E Sbjct: 436 NRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEK- 494 Query: 444 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKT 482 AD +F DL+ +ML D RI P L H F T Sbjct: 495 ---ADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMT 530 Score = 30.8 bits (68), Expect = 4.9 Identities = 67/291 (23%), Positives = 97/291 (33%), Gaps = 40/291 (13%) Query: 442 SGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADE--GTNTSNSVSTSPAM 499 +GH A+ K + +P+T I P Q S D NTS+ S + Sbjct: 915 AGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHH---SSSY 971 Query: 500 EQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQAMDCETHSPQVR 559 + SS TS++ SSG SSG T++ + G HF + Sbjct: 972 KSKSSSNVTSTSGHSSGSSSGAI---------TYRQQRPGPHF----------------Q 1006 Query: 560 QQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHH 619 QQ P L + T T +H Q+ Q H NS H H H Sbjct: 1007 QQQPLNLSQAQQHITTDRT-GSHRRQQAYITPTMAQAPYSFPH-NSPSHGTVHPHLAAAA 1064 Query: 620 GQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSS--TTSSSTSSSSTGNQGN 677 L + Y +P ST G H + S S+ T + +S +Q Sbjct: 1065 AAAHLPTQPHLYTYTAPAALGST------GTVAHLVASQGSARHTVQHTAYPASIVHQVP 1118 Query: 678 QAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGP 728 + R + + T+ Q A + T S T G+P N P Sbjct: 1119 VSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYP 1169 >gi|164420685 homeodomain interacting protein kinase 2 isoform 1 [Homo sapiens] Length = 1198 Score = 222 bits (565), Expect = 1e-57 Identities = 134/339 (39%), Positives = 187/339 (55%), Gaps = 22/339 (6%) Query: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218 YE+ +G+G+FGQVVK + R E VAIKI+KN ++ Q QIEV +L ++ + Sbjct: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257 Query: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278 Y V F +NH CLVFEML NLYD L+ F + L R QQ+ TAL+ L + Sbjct: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317 Query: 279 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 335 L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR+PE++LG Sbjct: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 375 Query: 336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395 +P+ AIDMWSLGC++ E+ G PL+ GA+E DQ+ I + G+P ++L K +FF Sbjct: 376 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 435 Query: 396 EKLPDG---TWNLKKTKDGKRE--YKPPGTRK-LHNIL------GVETGGPGGRRAGESG 443 + D W LK D + E K RK + N L + T G E Sbjct: 436 NRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEK- 494 Query: 444 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKT 482 AD +F DL+ +ML D RI P L H F T Sbjct: 495 ---ADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMT 530 Score = 30.8 bits (68), Expect = 4.9 Identities = 67/291 (23%), Positives = 97/291 (33%), Gaps = 40/291 (13%) Query: 442 SGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADE--GTNTSNSVSTSPAM 499 +GH A+ K + +P+T I P Q S D NTS+ S + Sbjct: 942 AGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHH---SSSY 998 Query: 500 EQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQAMDCETHSPQVR 559 + SS TS++ SSG SSG T++ + G HF + Sbjct: 999 KSKSSSNVTSTSGHSSGSSSGAI---------TYRQQRPGPHF----------------Q 1033 Query: 560 QQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHH 619 QQ P L + T T +H Q+ Q H NS H H H Sbjct: 1034 QQQPLNLSQAQQHITTDRT-GSHRRQQAYITPTMAQAPYSFPH-NSPSHGTVHPHLAAAA 1091 Query: 620 GQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSS--TTSSSTSSSSTGNQGN 677 L + Y +P ST G H + S S+ T + +S +Q Sbjct: 1092 AAAHLPTQPHLYTYTAPAALGST------GTVAHLVASQGSARHTVQHTAYPASIVHQVP 1145 Query: 678 QAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGP 728 + R + + T+ Q A + T S T G+P N P Sbjct: 1146 VSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYP 1196 >gi|38201640 homeodomain-interacting protein kinase 1 isoform 1 [Homo sapiens] Length = 1210 Score = 221 bits (564), Expect = 2e-57 Identities = 131/339 (38%), Positives = 191/339 (56%), Gaps = 22/339 (6%) Query: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218 YE+ +G+G+FGQV K + R +E VAIKI+KN ++ Q QIEV +L ++ + + + Sbjct: 190 YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENAD-E 248 Query: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278 Y V F +NH CLVFEML NLYD L+ F + L R QQ+ TAL+ L + Sbjct: 249 YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS 308 Query: 279 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 335 L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR+PE++LG Sbjct: 309 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 366 Query: 336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395 +P+ AIDMWSLGC++ E+ G PL+ GA+E DQ+ I + G+P ++L K +FF Sbjct: 367 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 426 Query: 396 EKLPD---GTWNLKKTKDGKRE--YKPPGTRK-LHNIL------GVETGGPGGRRAGESG 443 + P+ W LK ++ + E K RK + N L + T G E Sbjct: 427 NRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEK- 485 Query: 444 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKT 482 AD ++ DL+ +ML D RI P L H F T Sbjct: 486 ---ADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMT 521 >gi|38201638 homeodomain-interacting protein kinase 1 isoform 2 [Homo sapiens] Length = 1075 Score = 221 bits (564), Expect = 2e-57 Identities = 131/339 (38%), Positives = 191/339 (56%), Gaps = 22/339 (6%) Query: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218 YE+ +G+G+FGQV K + R +E VAIKI+KN ++ Q QIEV +L ++ + + + Sbjct: 190 YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENAD-E 248 Query: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278 Y V F +NH CLVFEML NLYD L+ F + L R QQ+ TAL+ L + Sbjct: 249 YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS 308 Query: 279 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 335 L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR+PE++LG Sbjct: 309 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 366 Query: 336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395 +P+ AIDMWSLGC++ E+ G PL+ GA+E DQ+ I + G+P ++L K +FF Sbjct: 367 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 426 Query: 396 EKLPD---GTWNLKKTKDGKRE--YKPPGTRK-LHNIL------GVETGGPGGRRAGESG 443 + P+ W LK ++ + E K RK + N L + T G E Sbjct: 427 NRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEK- 485 Query: 444 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKT 482 AD ++ DL+ +ML D RI P L H F T Sbjct: 486 ---ADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMT 521 >gi|114796630 homeodomain interacting protein kinase 3 isoform 2 [Homo sapiens] Length = 1194 Score = 215 bits (548), Expect = 1e-55 Identities = 133/335 (39%), Positives = 188/335 (56%), Gaps = 22/335 (6%) Query: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218 YE+ +G+G+FGQVVK + R E VAIKI+KN ++ Q QIEV +L ++ + + + Sbjct: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENAD-E 255 Query: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278 Y V F RNH CLVFEML NLYD L+ F + L + R QQ+ TAL L + Sbjct: 256 YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS 315 Query: 279 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 335 L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR+PE++LG Sbjct: 316 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILG 373 Query: 336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395 +P+ AIDMWSLGC++ E+ G PL+ GA E DQ+ I + G+P +L+ K+ +FF Sbjct: 374 LPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFF 433 Query: 396 EKLPD---GTWNLKKTKDGKRE--YKPPGTRK-----LHNILGVET--GGPGGRRAGESG 443 K D W LK ++ + E K RK L ++ V T G E Sbjct: 434 CKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEK- 492 Query: 444 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSF 478 AD +F L+ +ML D RI P L H F Sbjct: 493 ---ADRREFVSLLKKMLLIDADLRITPAETLNHPF 524 >gi|114796624 homeodomain interacting protein kinase 3 isoform 1 [Homo sapiens] Length = 1215 Score = 215 bits (548), Expect = 1e-55 Identities = 133/335 (39%), Positives = 188/335 (56%), Gaps = 22/335 (6%) Query: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218 YE+ +G+G+FGQVVK + R E VAIKI+KN ++ Q QIEV +L ++ + + + Sbjct: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENAD-E 255 Query: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278 Y V F RNH CLVFEML NLYD L+ F + L + R QQ+ TAL L + Sbjct: 256 YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS 315 Query: 279 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 335 L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR+PE++LG Sbjct: 316 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILG 373 Query: 336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395 +P+ AIDMWSLGC++ E+ G PL+ GA E DQ+ I + G+P +L+ K+ +FF Sbjct: 374 LPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFF 433 Query: 396 EKLPD---GTWNLKKTKDGKRE--YKPPGTRK-----LHNILGVET--GGPGGRRAGESG 443 K D W LK ++ + E K RK L ++ V T G E Sbjct: 434 CKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEK- 492 Query: 444 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSF 478 AD +F L+ +ML D RI P L H F Sbjct: 493 ---ADRREFVSLLKKMLLIDADLRITPAETLNHPF 524 >gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens] Length = 616 Score = 200 bits (508), Expect = 5e-51 Identities = 129/341 (37%), Positives = 183/341 (53%), Gaps = 22/341 (6%) Query: 157 DRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE 216 D Y+I ++GKG+FG+V K + R E VAIKI+KN + E++LL M D E Sbjct: 9 DCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPE 68 Query: 217 MKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFL 276 + +++ F LVFE+L NL++ + NF + R Q+ TAL L Sbjct: 69 -EAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARL 127 Query: 277 ATPELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIY---QYIQSRFYRSPE 331 EL+IIH DLKPENI+L + R +K++DFGS+ + Y YIQSRFYR+PE Sbjct: 128 K--ELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPE 185 Query: 332 VLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKA 391 +LLG+P+ +D+WSLGC++ E+H G PL+ G NE DQ+ I E G+P H+L A KA Sbjct: 186 ILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKA 245 Query: 392 RKFFEKLPD----GTWNLKKTKD--GKREYKPPGTRK-----LHNILGVETGGPGGRRAG 440 FF++ P W LK + D + + +P RK L I V G R Sbjct: 246 HHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTF 305 Query: 441 ESGHTVADYLKFK---DLILRMLDYDPKTRIQPYYALQHSF 478 +A++ K +LI RML ++ RI P AL+H F Sbjct: 306 PDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPF 346 >gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens] Length = 526 Score = 172 bits (435), Expect = 1e-42 Identities = 116/395 (29%), Positives = 190/395 (48%), Gaps = 47/395 (11%) Query: 103 TYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEID 162 +YK + ++++ H++ G K+ R V DD+ I ++G+ RYEI Sbjct: 154 SYKSKHRIHHSTS---HRRSHGKSHRRKRTRSVE----DDEEGHLICQSGDVLSARYEIV 206 Query: 163 SLIGKGSFGQVVKAYD-RVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYI 221 +G+G+FG+VV+ D + VA+KI+KN + A+ E+++LE +N D + Sbjct: 207 DTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRC 266 Query: 222 VHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPEL 281 V + F H+C+VFE+L + YD ++ F L+ RK A Q+C ++ FL + +L Sbjct: 267 VQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKL 326 Query: 282 SIIHCDLKPENILLC--------NPK---------RSAIKIVDFGSSCQLGQRIYQYIQS 324 + H DLKPENIL NPK IK+VDFGS+ + + + Sbjct: 327 T--HTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVST 384 Query: 325 RFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHI 384 R YR+PEV+L + + D+WS+GCIL+E + G +F + + + + +LG P H+ Sbjct: 385 RHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHM 444 Query: 385 LDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGH 444 + + K + F D + + R KP L + Sbjct: 445 IQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDV----------------- 487 Query: 445 TVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 479 ++ + DLI +ML+YDP RI AL+H FF Sbjct: 488 ---EHERLFDLIQKMLEYDPAKRITLREALKHPFF 519 >gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens] Length = 484 Score = 172 bits (435), Expect = 1e-42 Identities = 116/395 (29%), Positives = 190/395 (48%), Gaps = 47/395 (11%) Query: 103 TYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEID 162 +YK + ++++ H++ G K+ R V DD+ I ++G+ RYEI Sbjct: 112 SYKSKHRIHHSTS---HRRSHGKSHRRKRTRSVE----DDEEGHLICQSGDVLSARYEIV 164 Query: 163 SLIGKGSFGQVVKAYD-RVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYI 221 +G+G+FG+VV+ D + VA+KI+KN + A+ E+++LE +N D + Sbjct: 165 DTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRC 224 Query: 222 VHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPEL 281 V + F H+C+VFE+L + YD ++ F L+ RK A Q+C ++ FL + +L Sbjct: 225 VQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKL 284 Query: 282 SIIHCDLKPENILLC--------NPK---------RSAIKIVDFGSSCQLGQRIYQYIQS 324 + H DLKPENIL NPK IK+VDFGS+ + + + Sbjct: 285 T--HTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVST 342 Query: 325 RFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHI 384 R YR+PEV+L + + D+WS+GCIL+E + G +F + + + + +LG P H+ Sbjct: 343 RHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHM 402 Query: 385 LDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGH 444 + + K + F D + + R KP L + Sbjct: 403 IQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDV----------------- 445 Query: 445 TVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 479 ++ + DLI +ML+YDP RI AL+H FF Sbjct: 446 ---EHERLFDLIQKMLEYDPAKRITLREALKHPFF 477 >gi|10190706 CDC-like kinase 4 [Homo sapiens] Length = 481 Score = 172 bits (435), Expect = 1e-42 Identities = 112/385 (29%), Positives = 189/385 (49%), Gaps = 43/385 (11%) Query: 115 KKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIV-KNGEKWMDRYEIDSLIGKGSFGQV 173 K++R++ S K R+ + +DD +++ ++G+ RYEI +G+G+FG+V Sbjct: 114 KRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKV 173 Query: 174 VKAYDR-VEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRN 232 V+ D ++ VA+KI+KN + A+ E+++LE +N D + V + F Sbjct: 174 VECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHG 233 Query: 233 HLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPEN 292 H+C+VFE+L + YD ++ +F ++ R+ A Q+C ++ FL +L+ H DLKPEN Sbjct: 234 HVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLT--HTDLKPEN 291 Query: 293 ILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLG 335 IL K + IK+VDFGS+ + + +R YR+PEV+L Sbjct: 292 ILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILA 351 Query: 336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395 + + D+WS+GCIL+E + G +F + + + + +LG P H++ + K + F Sbjct: 352 LGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFH 411 Query: 396 EKLPDGTWNLKKTKDGKREYKPPGTRKL-HNILGVETGGPGGRRAGESGHTVADYLKFKD 454 D + + +R KP L H+ ++ K D Sbjct: 412 HNQLDWDEHSSAGRYVRRRCKPLKEFMLCHD---------------------EEHEKLFD 450 Query: 455 LILRMLDYDPKTRIQPYYALQHSFF 479 L+ RML+YDP RI ALQH FF Sbjct: 451 LVRRMLEYDPTQRITLDEALQHPFF 475 >gi|47717134 CDC-like kinase 2 [Homo sapiens] Length = 498 Score = 171 bits (434), Expect = 2e-42 Identities = 117/394 (29%), Positives = 197/394 (50%), Gaps = 44/394 (11%) Query: 114 KKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWM-DRYEIDSLIGKGSFGQ 172 +++RR + SSH R +DD +++ + W+ +RYEI S +G+G+FG+ Sbjct: 119 RRRRRRSRTFSRSSSHSSRRA---KSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGR 175 Query: 173 VVKAYD-RVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFR 231 VV+ D R VA+KIIKN + + A++E+ +LE +N+ D + K V + F + Sbjct: 176 VVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYH 235 Query: 232 NHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPE 291 H+C+ FE+L + +D L++ N+ ++ R A Q+C A+ FL +L+ H DLKPE Sbjct: 236 GHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLT--HTDLKPE 293 Query: 292 NILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLL 334 NIL N K +A+++VDFGS+ + + +R YR+PEV+L Sbjct: 294 NILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVIL 353 Query: 335 GMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKF 394 + + D+WS+GCI+ E + G LF + + + + +LG P+ ++ + K + F Sbjct: 354 ELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYF 413 Query: 395 FEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKD 454 + D W+ + T G+ Y + L L E ++ + D Sbjct: 414 YRGRLD--WD-ENTSAGR--YVRENCKPLRRYLTSE---------------AEEHHQLFD 453 Query: 455 LILRMLDYDPKTRIQPYYALQHSFFKKTADEGTN 488 LI ML+Y+P R+ ALQH FF + E N Sbjct: 454 LIESMLEYEPAKRLTLGEALQHPFFARLRAEPPN 487 >gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens] Length = 638 Score = 171 bits (434), Expect = 2e-42 Identities = 114/397 (28%), Positives = 191/397 (48%), Gaps = 46/397 (11%) Query: 104 YKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDS 163 Y+ ++ K+R S + ++ DD + + G+ +RYEI Sbjct: 249 YRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVG 308 Query: 164 LIGKGSFGQVVKAYDRVE-QEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIV 222 +G+G+FG+VV+ D + VA+KII+N + A++E+ +L+ + + D E K+ V Sbjct: 309 NLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCV 368 Query: 223 HLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELS 282 + F F H+C+ FE+L N ++ L+ NF+ L R A Q+C AL FL +L+ Sbjct: 369 LMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLT 428 Query: 283 IIHCDLKPENILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYIQSR 325 H DLKPENIL N K ++I++ DFGS+ + + +R Sbjct: 429 --HTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATR 486 Query: 326 FYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHIL 385 YR PEV+L + + D+WS+GCIL E + G LF + + + ++LG P+H++ Sbjct: 487 HYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMI 546 Query: 386 DQAPKARKFFEKLPDGTWNLKKTKDG---KREYKPPGTRKLHNILGVETGGPGGRRAGES 442 + K + F++ W+ + + DG K KP + L + L Sbjct: 547 HRTRKQKYFYK--GGLVWD-ENSSDGRYVKENCKPLKSYMLQDSL--------------- 588 Query: 443 GHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 479 ++++ DL+ RML++DP RI AL H FF Sbjct: 589 -----EHVQLFDLMRRMLEFDPAQRITLAEALLHPFF 620 >gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens] Length = 490 Score = 171 bits (434), Expect = 2e-42 Identities = 114/397 (28%), Positives = 191/397 (48%), Gaps = 46/397 (11%) Query: 104 YKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDS 163 Y+ ++ K+R S + ++ DD + + G+ +RYEI Sbjct: 101 YRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVG 160 Query: 164 LIGKGSFGQVVKAYDRVE-QEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIV 222 +G+G+FG+VV+ D + VA+KII+N + A++E+ +L+ + + D E K+ V Sbjct: 161 NLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCV 220 Query: 223 HLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELS 282 + F F H+C+ FE+L N ++ L+ NF+ L R A Q+C AL FL +L+ Sbjct: 221 LMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLT 280 Query: 283 IIHCDLKPENILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYIQSR 325 H DLKPENIL N K ++I++ DFGS+ + + +R Sbjct: 281 --HTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATR 338 Query: 326 FYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHIL 385 YR PEV+L + + D+WS+GCIL E + G LF + + + ++LG P+H++ Sbjct: 339 HYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMI 398 Query: 386 DQAPKARKFFEKLPDGTWNLKKTKDG---KREYKPPGTRKLHNILGVETGGPGGRRAGES 442 + K + F++ W+ + + DG K KP + L + L Sbjct: 399 HRTRKQKYFYK--GGLVWD-ENSSDGRYVKENCKPLKSYMLQDSL--------------- 440 Query: 443 GHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 479 ++++ DL+ RML++DP RI AL H FF Sbjct: 441 -----EHVQLFDLMRRMLEFDPAQRITLAEALLHPFF 472 >gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens] Length = 1007 Score = 169 bits (429), Expect = 7e-42 Identities = 123/374 (32%), Positives = 191/374 (51%), Gaps = 15/374 (4%) Query: 112 YAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFG 171 Y R G G D KE D + D Y V GE RY + G+G F Sbjct: 643 YFDSARLRAAGIGKDF---KENPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFS 699 Query: 172 QVVKAYD--RVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFM 229 VV+A D R QE VA+KII+N + E+ L+ +N D + K++ + L RHF Sbjct: 700 NVVRARDNARANQE-VAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFY 758 Query: 230 FRNHLCLVFEMLSYNLYDLLRNTNFR-GVSLNLTRKFAQQMCTALLFLATPELSIIHCDL 288 + HLCLVFE LS NL ++L+ G+ + R ++QQ+ AL L +I+H D+ Sbjct: 759 HKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLK--RCNILHADI 816 Query: 289 KPENILLCNPKRSAIKIVDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGMPYDLAIDMWSL 347 KP+NIL+ N ++ +K+ DFGS+ + I Y+ SRFYR+PE+++G YD IDMWS+ Sbjct: 817 KPDNILV-NESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSV 875 Query: 348 GCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKK 407 GC L E++TG+ LF G + +++ G P ++ + + F++ + + ++ Sbjct: 876 GCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMY-IEV 934 Query: 408 TKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTR 467 K +RE K ++ + G +R E L KDL+ ++L DP R Sbjct: 935 DKVTERE-KVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQL--KDLLDQILMLDPAKR 991 Query: 468 IQPYYALQHSFFKK 481 I ALQH+F ++ Sbjct: 992 ISINQALQHAFIQE 1005 >gi|169171014 PREDICTED: similar to homeodomain interacting protein kinase 2 [Homo sapiens] Length = 460 Score = 137 bits (345), Expect = 4e-32 Identities = 75/173 (43%), Positives = 105/173 (60%), Gaps = 6/173 (3%) Query: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218 YE+ +G+G+FGQVVK + R E VAIKI+KN ++ Q QIEV +L ++ + Sbjct: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257 Query: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278 Y V F +NH CLVFEML NLYD L+ F + L R QQ+ TAL+ L + Sbjct: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317 Query: 279 PELSIIHCDLKPENILLCNPKRS--AIKIVDFGSSCQLGQRIYQ-YIQSRFYR 328 L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR Sbjct: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYR 368 >gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens] Length = 1030 Score = 134 bits (338), Expect = 2e-31 Identities = 82/231 (35%), Positives = 133/231 (57%), Gaps = 12/231 (5%) Query: 156 MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDT 215 M+++EI ++G+G++G V+K + E VAIK K+ + + +R L+++ T Sbjct: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLR---T 66 Query: 216 EMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLF 275 + IV LK F R L LVFE + N+ +LL GV + + Q+ A+ + Sbjct: 67 LKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMP-NGVPPEKVKSYIYQLIKAIHW 125 Query: 276 LATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQ----RIYQYIQSRFYRSPE 331 + I+H D+KPEN+L+ + +K+ DFG + L + +Y+ +R+YRSPE Sbjct: 126 CHKND--IVHRDIKPENLLISH--NDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPE 181 Query: 332 VLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPA 382 +LLG PY ++DMWS+GCIL E+ G+PLF G +E+DQ+ I +VLG P+ Sbjct: 182 LLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPS 232 >gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens] Length = 1030 Score = 134 bits (338), Expect = 2e-31 Identities = 82/231 (35%), Positives = 133/231 (57%), Gaps = 12/231 (5%) Query: 156 MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDT 215 M+++EI ++G+G++G V+K + E VAIK K+ + + +R L+++ T Sbjct: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLR---T 66 Query: 216 EMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLF 275 + IV LK F R L LVFE + N+ +LL GV + + Q+ A+ + Sbjct: 67 LKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMP-NGVPPEKVKSYIYQLIKAIHW 125 Query: 276 LATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQ----RIYQYIQSRFYRSPE 331 + I+H D+KPEN+L+ + +K+ DFG + L + +Y+ +R+YRSPE Sbjct: 126 CHKND--IVHRDIKPENLLISH--NDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPE 181 Query: 332 VLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPA 382 +LLG PY ++DMWS+GCIL E+ G+PLF G +E+DQ+ I +VLG P+ Sbjct: 182 LLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPS 232 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.316 0.130 0.387 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 31,090,820 Number of Sequences: 37866 Number of extensions: 1506762 Number of successful extensions: 16594 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 637 Number of HSP's successfully gapped in prelim test: 395 Number of HSP's that attempted gapping in prelim test: 8527 Number of HSP's gapped (non-prelim): 4243 length of query: 763 length of database: 18,247,518 effective HSP length: 110 effective length of query: 653 effective length of database: 14,082,258 effective search space: 9195714474 effective search space used: 9195714474 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.