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Search of human proteins with 18765752
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation
regulated kinase 1A isoform 2 [Homo sapiens]
(754 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regula... 1554 0.0
gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regula... 1546 0.0
gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regula... 1118 0.0
gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regula... 1029 0.0
gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regula... 1024 0.0
gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulat... 746 0.0
gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulat... 684 0.0
gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulat... 666 0.0
gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regula... 283 3e-76
gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regula... 278 1e-74
gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regula... 278 1e-74
gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation regul... 277 3e-74
gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulat... 277 3e-74
gi|164420691 homeodomain interacting protein kinase 2 isoform 2 ... 222 1e-57
gi|164420685 homeodomain interacting protein kinase 2 isoform 1 ... 222 1e-57
gi|38201640 homeodomain-interacting protein kinase 1 isoform 1 [... 221 1e-57
gi|38201638 homeodomain-interacting protein kinase 1 isoform 2 [... 221 1e-57
gi|114796630 homeodomain interacting protein kinase 3 isoform 2 ... 215 1e-55
gi|114796624 homeodomain interacting protein kinase 3 isoform 1 ... 215 1e-55
gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens] 200 5e-51
gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens] 177 2e-44
gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens] 177 2e-44
gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens] 172 1e-42
gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens] 172 1e-42
gi|10190706 CDC-like kinase 4 [Homo sapiens] 172 1e-42
gi|47717134 CDC-like kinase 2 [Homo sapiens] 171 2e-42
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens] 169 7e-42
gi|169171014 PREDICTED: similar to homeodomain interacting prote... 137 4e-32
gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens] 134 2e-31
gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens] 134 2e-31
>gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 2 [Homo sapiens]
Length = 754
Score = 1554 bits (4024), Expect = 0.0
Identities = 754/754 (100%), Positives = 754/754 (100%)
Query: 1 MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD 60
MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD
Sbjct: 1 MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD 60
Query: 61 QIQQPLTNQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSH 120
QIQQPLTNQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSH
Sbjct: 61 QIQQPLTNQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSH 120
Query: 121 KKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKI 180
KKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKI
Sbjct: 121 KKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKI 180
Query: 181 IKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLL 240
IKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLL
Sbjct: 181 IKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLL 240
Query: 241 RNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFG 300
RNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFG
Sbjct: 241 RNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFG 300
Query: 301 SSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQ 360
SSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQ
Sbjct: 301 SSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQ 360
Query: 361 MNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGV 420
MNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGV
Sbjct: 361 MNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGV 420
Query: 421 ETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNT 480
ETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNT
Sbjct: 421 ETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNT 480
Query: 481 SNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQAM 540
SNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQAM
Sbjct: 481 SNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQAM 540
Query: 541 DCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHHHHGNSSHHH 600
DCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHHHHGNSSHHH
Sbjct: 541 DCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHHHHGNSSHHH 600
Query: 601 HHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSSTTSSSTSS 660
HHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSSTTSSSTSS
Sbjct: 601 HHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSSTTSSSTSS 660
Query: 661 SSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGPA 720
SSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGPA
Sbjct: 661 SSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGPA 720
Query: 721 HYMTEGHLTMRQGADREESPMTGVCVQQSPVASS 754
HYMTEGHLTMRQGADREESPMTGVCVQQSPVASS
Sbjct: 721 HYMTEGHLTMRQGADREESPMTGVCVQQSPVASS 754
>gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 1 [Homo sapiens]
Length = 763
Score = 1546 bits (4004), Expect = 0.0
Identities = 754/763 (98%), Positives = 754/763 (98%), Gaps = 9/763 (1%)
Query: 1 MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD 60
MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD
Sbjct: 1 MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD 60
Query: 61 QIQQPLTNQ---------RRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ 111
QIQQPLTNQ RRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ
Sbjct: 61 QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ 120
Query: 112 QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV 171
QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV
Sbjct: 121 QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV 180
Query: 172 EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM 231
EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM
Sbjct: 181 EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM 240
Query: 232 LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR 291
LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR
Sbjct: 241 LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR 300
Query: 292 SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL 351
SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL
Sbjct: 301 SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL 360
Query: 352 FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT 411
FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT
Sbjct: 361 FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT 420
Query: 412 RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 471
RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK
Sbjct: 421 RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 480
Query: 472 KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGG 531
KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGG
Sbjct: 481 KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGG 540
Query: 532 HFTAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHH 591
HFTAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHH
Sbjct: 541 HFTAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHH 600
Query: 592 HHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSS 651
HHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSS
Sbjct: 601 HHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSS 660
Query: 652 STTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTY 711
STTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTY
Sbjct: 661 STTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTY 720
Query: 712 QFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS 754
QFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS
Sbjct: 721 QFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS 763
>gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 3 [Homo sapiens]
Length = 584
Score = 1118 bits (2893), Expect = 0.0
Identities = 555/577 (96%), Positives = 555/577 (96%), Gaps = 15/577 (2%)
Query: 1 MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD 60
MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD
Sbjct: 1 MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD 60
Query: 61 QIQQPLTNQ---------RRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ 111
QIQQPLTNQ RRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ
Sbjct: 61 QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ 120
Query: 112 QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV 171
QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV
Sbjct: 121 QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV 180
Query: 172 EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM 231
EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM
Sbjct: 181 EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM 240
Query: 232 LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR 291
LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR
Sbjct: 241 LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR 300
Query: 292 SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL 351
SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL
Sbjct: 301 SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL 360
Query: 352 FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT 411
FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT
Sbjct: 361 FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT 420
Query: 412 RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 471
RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK
Sbjct: 421 RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 480
Query: 472 KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGG 531
KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGG
Sbjct: 481 KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGG 540
Query: 532 HFTAAVQAMDCETHSPQVRQQF------PAPLGWSGT 562
HFTAAVQAMDCETHSPQV PA L WS T
Sbjct: 541 HFTAAVQAMDCETHSPQVSSHVVHLLVSPAILRWSST 577
Score = 30.0 bits (66), Expect = 8.3
Identities = 17/47 (36%), Positives = 28/47 (59%)
Query: 628 TNSSSTQDSMEVGHSHHSMTSLSSSTTSSSTSSSSTGNQGNQAYQNR 674
+NS ST +ME S + +S SSS+ SS +S+S + + +Q+R
Sbjct: 490 SNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHR 536
>gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 5 [Homo sapiens]
Length = 529
Score = 1029 bits (2660), Expect = 0.0
Identities = 510/528 (96%), Positives = 513/528 (97%), Gaps = 9/528 (1%)
Query: 1 MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD 60
MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD
Sbjct: 1 MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD 60
Query: 61 QIQQPLTNQ---------RRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ 111
QIQQPLTNQ RRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ
Sbjct: 61 QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ 120
Query: 112 QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV 171
QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV
Sbjct: 121 QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV 180
Query: 172 EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM 231
EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM
Sbjct: 181 EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM 240
Query: 232 LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR 291
LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR
Sbjct: 241 LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR 300
Query: 292 SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL 351
SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL
Sbjct: 301 SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL 360
Query: 352 FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT 411
FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT
Sbjct: 361 FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT 420
Query: 412 RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 471
RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK
Sbjct: 421 RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 480
Query: 472 KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRAR 519
KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSG S+ + +S R
Sbjct: 481 KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGASAISCSSWLVR 528
>gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 4 [Homo sapiens]
Length = 540
Score = 1024 bits (2647), Expect = 0.0
Identities = 506/515 (98%), Positives = 506/515 (98%), Gaps = 9/515 (1%)
Query: 1 MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD 60
MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD
Sbjct: 1 MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD 60
Query: 61 QIQQPLTNQ---------RRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ 111
QIQQPLTNQ RRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ
Sbjct: 61 QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ 120
Query: 112 QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV 171
QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV
Sbjct: 121 QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV 180
Query: 172 EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM 231
EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM
Sbjct: 181 EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM 240
Query: 232 LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR 291
LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR
Sbjct: 241 LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR 300
Query: 292 SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL 351
SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL
Sbjct: 301 SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL 360
Query: 352 FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT 411
FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT
Sbjct: 361 FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT 420
Query: 412 RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 471
RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK
Sbjct: 421 RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 480
Query: 472 KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSS 506
KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSS
Sbjct: 481 KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSS 515
>gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform a [Homo sapiens]
Length = 629
Score = 746 bits (1926), Expect = 0.0
Identities = 372/499 (74%), Positives = 423/499 (84%), Gaps = 10/499 (2%)
Query: 70 RRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYND 129
RR+P FRD +APLRKLSVDLIKTYKHINEVYYAKKKRR QQ DSS+KKE+KV N
Sbjct: 31 RRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNH 90
Query: 130 GYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLN 189
GYDDDN+DYIV++GE+W++RYEIDSLIGKGSFGQVVKAYD QE VAIKIIKNKKAFLN
Sbjct: 91 GYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLN 150
Query: 190 QAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVS 249
QAQIE+RLLELMN+HDTEMKYYIVHLKRHFMFRNHLCLVFE+LSYNLYDLLRNT+FRGVS
Sbjct: 151 QAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS 210
Query: 250 LNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRI 309
LNLTRK AQQ+CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRI
Sbjct: 211 LNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRI 270
Query: 310 YQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLG 369
YQYIQSRFYRSPEVLLG PYDLAIDMWSLGCILVEMHTGEPLFSG+NEVDQMN+IVEVLG
Sbjct: 271 YQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLG 330
Query: 370 IPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRR 429
IPPA +LDQAPKARK+FE+LP G W L++TK+ +++Y+ PGTR+L +LGV+TGGPGGRR
Sbjct: 331 IPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRR 390
Query: 430 AGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNT---SNSVST 486
AGE GH+ ADYL+F+DL+LRML+Y+P RI P ALQH FF++TADE TNT +S ST
Sbjct: 391 AGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSAST 450
Query: 487 SPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQAMDCETHS 546
SPA + S +T+S+ SSSGGSSG+S+ R + +R+ GG DCE +S
Sbjct: 451 SPAPLDTCPSSSTASSISSSGGSSGSSSDNRTY---RYSNRYCGG---PGPPITDCEMNS 504
Query: 547 PQVRQQFPAPLGWSGTEAP 565
PQV P W+G + P
Sbjct: 505 PQVPPSQPL-RPWAGGDVP 522
>gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform c [Homo sapiens]
Length = 601
Score = 684 bits (1766), Expect = 0.0
Identities = 351/499 (70%), Positives = 398/499 (79%), Gaps = 38/499 (7%)
Query: 70 RRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYND 129
RR+P FRD +APLRKLSVDLIKTYKHINEVYYAKKKRR QQ DSS+KKE+KV N
Sbjct: 31 RRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNH 90
Query: 130 GYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLN 189
GYDDDN+DYIV++GE+W++RYEIDSLIGKGSFGQVVKAYD QE VAIKIIKNKKAFLN
Sbjct: 91 GYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLN 150
Query: 190 QAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVS 249
QAQIE+RLLELMN+HDTEMKYYIVHLKRHFMFRNHLCLVFE+LSYNLYDLLRNT+FRGVS
Sbjct: 151 QAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS 210
Query: 250 LNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRI 309
LNLTRK AQQ+CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRI
Sbjct: 211 LNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRI 270
Query: 310 YQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLG 369
YQYIQSRFYRSPEVLLG PYDLAIDMWSLGCILVEMHTGEPLFSG+NEVDQMN+IVEVLG
Sbjct: 271 YQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLG 330
Query: 370 IPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRR 429
IPPA +LDQAPKARK+FE+LP G W L++TK+ +++Y+ PGTR+L
Sbjct: 331 IPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQ-------------- 376
Query: 430 AGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNT---SNSVST 486
+DL+LRML+Y+P RI P ALQH FF++TADE TNT +S ST
Sbjct: 377 --------------EDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSAST 422
Query: 487 SPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQAMDCETHS 546
SPA + S +T+S+ SSSGGSSG+S+ R + +R+ GG DCE +S
Sbjct: 423 SPAPLDTCPSSSTASSISSSGGSSGSSSDNRTY---RYSNRYCGG---PGPPITDCEMNS 476
Query: 547 PQVRQQFPAPLGWSGTEAP 565
PQV P W+G + P
Sbjct: 477 PQVPPSQPL-RPWAGGDVP 494
>gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform b [Homo sapiens]
Length = 589
Score = 666 bits (1719), Expect = 0.0
Identities = 346/499 (69%), Positives = 388/499 (77%), Gaps = 50/499 (10%)
Query: 70 RRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYND 129
RR+P FRD +APLRKLSVDLIKTYKHINEVYYAKKKRR QQ DSS+KKE+KV N
Sbjct: 31 RRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNH 90
Query: 130 GYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLN 189
GYDDDN+DYIV++GE+W++RYEIDSLIGKGSFGQVVKAYD QE VAIKIIKNKKAFLN
Sbjct: 91 GYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLN 150
Query: 190 QAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVS 249
QAQIE+RLLELMN+HDTEMKYYIVHLKRHFMFRNHLCLVFE+LSYNLYDLLRNT+FRGVS
Sbjct: 151 QAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS 210
Query: 250 LNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRI 309
LNLTRK AQQ+CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRI
Sbjct: 211 LNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRI 270
Query: 310 YQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLG 369
YQYIQSRFYRSPEVLLG PYDLAIDMWSLGCILVEMHTGEPLFSG+NEVDQMN+IVEVLG
Sbjct: 271 YQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLG 330
Query: 370 IPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRR 429
IPPA +LDQAPKARK+FE+LP G W L++TK+ +
Sbjct: 331 IPPAAMLDQAPKARKYFERLPGGGWTLRRTKELR-------------------------- 364
Query: 430 AGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNT---SNSVST 486
KDL+LRML+Y+P RI P ALQH FF++TADE TNT +S ST
Sbjct: 365 --------------KDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSAST 410
Query: 487 SPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQAMDCETHS 546
SPA + S +T+S+ SSSGGSSG+S+ R + +R+ GG DCE +S
Sbjct: 411 SPAPLDTCPSSSTASSISSSGGSSGSSSDNRTY---RYSNRYCGG---PGPPITDCEMNS 464
Query: 547 PQVRQQFPAPLGWSGTEAP 565
PQV P W+G + P
Sbjct: 465 PQVPPSQPL-RPWAGGDVP 482
>gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 4 [Homo sapiens]
Length = 520
Score = 283 bits (725), Expect = 3e-76
Identities = 166/436 (38%), Positives = 236/436 (54%), Gaps = 45/436 (10%)
Query: 125 KVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNK 184
K +DD++ Y+ + RYE+ IGKGSFGQV K D E VA+KII+NK
Sbjct: 79 KFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNK 138
Query: 185 KAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTN 244
K F QA +E+++LE + K D + Y +VH+K F FRNH C+ FE+L NLY+L++N N
Sbjct: 139 KRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNN 198
Query: 245 FRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQ 304
F+G SL++ R+F + L L+ + IIHCDLKPENI+L ++++K++DFGSSC
Sbjct: 199 FQGFSLSIVRRFTLSVLKCLQMLSVEK--IIHCDLKPENIVLYQKGQASVKVIDFGSSCY 256
Query: 305 LGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKI 364
Q++Y YIQSRFYRSPEV+LG PYD+AIDMWSLGCI E++TG PLF G NEV+Q+ I
Sbjct: 257 EHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACI 316
Query: 365 VEVLGIPPAHILDQAPKARKFFEK--LPDGTWNLKKTKDGKREYKPPGTRKLHNILGVET 422
+EVLG+PPA + A + + FF+ P N + GK+ Y P ++ L +L
Sbjct: 317 MEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNR----GKKRY--PDSKDLTMVLKTYD 370
Query: 423 GGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTAD------- 475
F D + R L ++P R+ P AL+H++ ++ +
Sbjct: 371 ------------------TSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRP 412
Query: 476 EGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTA 535
+ SNS S + SS + T + + PT +HSG
Sbjct: 413 QTLRKSNSFFPSETRKDKVQGCHHSSRKADEITKETTE---KTKDSPTKHVQHSG----- 464
Query: 536 AVQAMDCETHSPQVRQ 551
DC H Q
Sbjct: 465 --DQQDCLQHGADTVQ 478
>gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform b [Homo sapiens]
Length = 568
Score = 278 bits (711), Expect = 1e-74
Identities = 165/442 (37%), Positives = 244/442 (55%), Gaps = 13/442 (2%)
Query: 48 ISDQQVSALSYSDQIQQPLTNQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKK 107
ISD + + + S N + + + P PL +K YKH Y +
Sbjct: 85 ISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAPKVVPLTPEQA--LKQYKHHLTAYEKLEI 142
Query: 108 RRHQQGQGDDSSHKKERKVY----NDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQ 163
+ + + KK V N GYDD + YI + RYE+ +IGKGSFGQ
Sbjct: 143 INYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQ 202
Query: 164 VVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRN 223
V + YD +++VA+K+++N+K F QA E+R+LE + K D ++H+ F FRN
Sbjct: 203 VARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRN 262
Query: 224 HLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPEN 283
H+C+ FE+LS +LY+L++ F+G S+ L RKFAQ + +L A + IIHCDLKPEN
Sbjct: 263 HVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD--ALHKNKIIHCDLKPEN 320
Query: 284 ILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILV 343
ILL + RS+ K++DFGSSC Q++Y YIQSRFYR+PE++LG Y ID+WS GCIL
Sbjct: 321 ILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILA 380
Query: 344 EMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGK 403
E+ TG+PLF G +E DQ+ ++E+LG+PP +L+Q+ +A+ F + T+
Sbjct: 381 ELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADG 440
Query: 404 REYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYY 463
R G + G + G PG + G + DYL F + + R L +DP R+ P
Sbjct: 441 RVVLVGGRSR----RGKKRGPPGSKDWGTALKGCDDYL-FIEFLKRCLHWDPSARLTPAQ 495
Query: 464 ALQHSFFKKTADEGTNTSNSVS 485
AL+H + K+ T + VS
Sbjct: 496 ALRHPWISKSVPRPLTTIDKVS 517
>gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform a [Homo sapiens]
Length = 588
Score = 278 bits (711), Expect = 1e-74
Identities = 165/442 (37%), Positives = 244/442 (55%), Gaps = 13/442 (2%)
Query: 48 ISDQQVSALSYSDQIQQPLTNQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKK 107
ISD + + + S N + + + P PL +K YKH Y +
Sbjct: 105 ISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAPKVVPLTPEQA--LKQYKHHLTAYEKLEI 162
Query: 108 RRHQQGQGDDSSHKKERKVY----NDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQ 163
+ + + KK V N GYDD + YI + RYE+ +IGKGSFGQ
Sbjct: 163 INYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQ 222
Query: 164 VVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRN 223
V + YD +++VA+K+++N+K F QA E+R+LE + K D ++H+ F FRN
Sbjct: 223 VARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRN 282
Query: 224 HLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPEN 283
H+C+ FE+LS +LY+L++ F+G S+ L RKFAQ + +L A + IIHCDLKPEN
Sbjct: 283 HVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD--ALHKNKIIHCDLKPEN 340
Query: 284 ILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILV 343
ILL + RS+ K++DFGSSC Q++Y YIQSRFYR+PE++LG Y ID+WS GCIL
Sbjct: 341 ILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILA 400
Query: 344 EMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGK 403
E+ TG+PLF G +E DQ+ ++E+LG+PP +L+Q+ +A+ F + T+
Sbjct: 401 ELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADG 460
Query: 404 REYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYY 463
R G + G + G PG + G + DYL F + + R L +DP R+ P
Sbjct: 461 RVVLVGGRSR----RGKKRGPPGSKDWGTALKGCDDYL-FIEFLKRCLHWDPSARLTPAQ 515
Query: 464 ALQHSFFKKTADEGTNTSNSVS 485
AL+H + K+ T + VS
Sbjct: 516 ALRHPWISKSVPRPLTTIDKVS 537
>gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation
regulated kinase 2 isoform 2 [Homo sapiens]
Length = 601
Score = 277 bits (708), Expect = 3e-74
Identities = 164/416 (39%), Positives = 228/416 (54%), Gaps = 31/416 (7%)
Query: 100 EVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKG 159
E+Y+ + +QG + N GYDDD Y+ + RYE+ +IGKG
Sbjct: 180 EIYFLGLNAKKRQGMTGGPN--------NGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKG 231
Query: 160 SFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHF 219
SFGQVVKAYD + VA+K+++N+K F QA E+R+LE + K D + ++H+ +F
Sbjct: 232 SFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENF 291
Query: 220 MFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDL 279
FRNH+C+ FE+LS NLY+L++ F+G SL L RKFA + L A + IIHCDL
Sbjct: 292 TFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLD--ALHKNRIIHCDL 349
Query: 280 KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLG 339
KPENILL RS IK++DFGSSC QR+Y YIQSRFYR+PEV+LG Y + IDMWSLG
Sbjct: 350 KPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLG 409
Query: 340 CILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTW-NLKK 398
CIL E+ TG PL G +E DQ+ ++E+LG+P +LD + +A+ F + +
Sbjct: 410 CILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTT 469
Query: 399 TKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTR 458
DG +R+ G G P R G + D L F D + + L++DP R
Sbjct: 470 LSDGSVVLNGGRSRR-----GKLRGPPESREWGNALKGCDDPL-FLDFLKQCLEWDPAVR 523
Query: 459 IQPYYALQHSFFK--------------KTADEGTNTSNSVSTSPAMEQSQSSGTTS 500
+ P AL+H + + K E T S+S P S S T+
Sbjct: 524 MTPGQALRHPWLRRRLPKPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTN 579
>gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 2 isoform 1 [Homo sapiens]
Length = 528
Score = 277 bits (708), Expect = 3e-74
Identities = 164/416 (39%), Positives = 228/416 (54%), Gaps = 31/416 (7%)
Query: 100 EVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKG 159
E+Y+ + +QG + N GYDDD Y+ + RYE+ +IGKG
Sbjct: 107 EIYFLGLNAKKRQGMTGGPN--------NGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKG 158
Query: 160 SFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHF 219
SFGQVVKAYD + VA+K+++N+K F QA E+R+LE + K D + ++H+ +F
Sbjct: 159 SFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENF 218
Query: 220 MFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDL 279
FRNH+C+ FE+LS NLY+L++ F+G SL L RKFA + L A + IIHCDL
Sbjct: 219 TFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLD--ALHKNRIIHCDL 276
Query: 280 KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLG 339
KPENILL RS IK++DFGSSC QR+Y YIQSRFYR+PEV+LG Y + IDMWSLG
Sbjct: 277 KPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLG 336
Query: 340 CILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTW-NLKK 398
CIL E+ TG PL G +E DQ+ ++E+LG+P +LD + +A+ F + +
Sbjct: 337 CILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTT 396
Query: 399 TKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTR 458
DG +R+ G G P R G + D L F D + + L++DP R
Sbjct: 397 LSDGSVVLNGGRSRR-----GKLRGPPESREWGNALKGCDDPL-FLDFLKQCLEWDPAVR 450
Query: 459 IQPYYALQHSFFK--------------KTADEGTNTSNSVSTSPAMEQSQSSGTTS 500
+ P AL+H + + K E T S+S P S S T+
Sbjct: 451 MTPGQALRHPWLRRRLPKPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTN 506
>gi|164420691 homeodomain interacting protein kinase 2 isoform 2
[Homo sapiens]
Length = 1171
Score = 222 bits (565), Expect = 1e-57
Identities = 134/339 (39%), Positives = 187/339 (55%), Gaps = 22/339 (6%)
Query: 150 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 209
YE+ +G+G+FGQVVK + R E VAIKI+KN ++ Q QIEV +L ++ +
Sbjct: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257
Query: 210 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 269
Y V F +NH CLVFEML NLYD L+ F + L R QQ+ TAL+ L +
Sbjct: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317
Query: 270 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 326
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR+PE++LG
Sbjct: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 375
Query: 327 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 386
+P+ AIDMWSLGC++ E+ G PL+ GA+E DQ+ I + G+P ++L K +FF
Sbjct: 376 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 435
Query: 387 EKLPDG---TWNLKKTKDGKRE--YKPPGTRK-LHNIL------GVETGGPGGRRAGESG 434
+ D W LK D + E K RK + N L + T G E
Sbjct: 436 NRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEK- 494
Query: 435 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKT 473
AD +F DL+ +ML D RI P L H F T
Sbjct: 495 ---ADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMT 530
Score = 30.8 bits (68), Expect = 4.8
Identities = 67/291 (23%), Positives = 97/291 (33%), Gaps = 40/291 (13%)
Query: 433 SGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADE--GTNTSNSVSTSPAM 490
+GH A+ K + +P+T I P Q S D NTS+ S +
Sbjct: 915 AGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHH---SSSY 971
Query: 491 EQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQAMDCETHSPQVR 550
+ SS TS++ SSG SSG T++ + G HF +
Sbjct: 972 KSKSSSNVTSTSGHSSGSSSGAI---------TYRQQRPGPHF----------------Q 1006
Query: 551 QQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHH 610
QQ P L + T T +H Q+ Q H NS H H H
Sbjct: 1007 QQQPLNLSQAQQHITTDRT-GSHRRQQAYITPTMAQAPYSFPH-NSPSHGTVHPHLAAAA 1064
Query: 611 GQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSS--TTSSSTSSSSTGNQGN 668
L + Y +P ST G H + S S+ T + +S +Q
Sbjct: 1065 AAAHLPTQPHLYTYTAPAALGST------GTVAHLVASQGSARHTVQHTAYPASIVHQVP 1118
Query: 669 QAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGP 719
+ R + + T+ Q A + T S T G+P N P
Sbjct: 1119 VSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYP 1169
>gi|164420685 homeodomain interacting protein kinase 2 isoform 1
[Homo sapiens]
Length = 1198
Score = 222 bits (565), Expect = 1e-57
Identities = 134/339 (39%), Positives = 187/339 (55%), Gaps = 22/339 (6%)
Query: 150 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 209
YE+ +G+G+FGQVVK + R E VAIKI+KN ++ Q QIEV +L ++ +
Sbjct: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257
Query: 210 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 269
Y V F +NH CLVFEML NLYD L+ F + L R QQ+ TAL+ L +
Sbjct: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317
Query: 270 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 326
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR+PE++LG
Sbjct: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 375
Query: 327 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 386
+P+ AIDMWSLGC++ E+ G PL+ GA+E DQ+ I + G+P ++L K +FF
Sbjct: 376 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 435
Query: 387 EKLPDG---TWNLKKTKDGKRE--YKPPGTRK-LHNIL------GVETGGPGGRRAGESG 434
+ D W LK D + E K RK + N L + T G E
Sbjct: 436 NRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEK- 494
Query: 435 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKT 473
AD +F DL+ +ML D RI P L H F T
Sbjct: 495 ---ADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMT 530
Score = 30.8 bits (68), Expect = 4.8
Identities = 67/291 (23%), Positives = 97/291 (33%), Gaps = 40/291 (13%)
Query: 433 SGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADE--GTNTSNSVSTSPAM 490
+GH A+ K + +P+T I P Q S D NTS+ S +
Sbjct: 942 AGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHH---SSSY 998
Query: 491 EQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQAMDCETHSPQVR 550
+ SS TS++ SSG SSG T++ + G HF +
Sbjct: 999 KSKSSSNVTSTSGHSSGSSSGAI---------TYRQQRPGPHF----------------Q 1033
Query: 551 QQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHH 610
QQ P L + T T +H Q+ Q H NS H H H
Sbjct: 1034 QQQPLNLSQAQQHITTDRT-GSHRRQQAYITPTMAQAPYSFPH-NSPSHGTVHPHLAAAA 1091
Query: 611 GQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSS--TTSSSTSSSSTGNQGN 668
L + Y +P ST G H + S S+ T + +S +Q
Sbjct: 1092 AAAHLPTQPHLYTYTAPAALGST------GTVAHLVASQGSARHTVQHTAYPASIVHQVP 1145
Query: 669 QAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGP 719
+ R + + T+ Q A + T S T G+P N P
Sbjct: 1146 VSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYP 1196
>gi|38201640 homeodomain-interacting protein kinase 1 isoform 1
[Homo sapiens]
Length = 1210
Score = 221 bits (564), Expect = 1e-57
Identities = 131/339 (38%), Positives = 191/339 (56%), Gaps = 22/339 (6%)
Query: 150 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 209
YE+ +G+G+FGQV K + R +E VAIKI+KN ++ Q QIEV +L ++ + + +
Sbjct: 190 YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENAD-E 248
Query: 210 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 269
Y V F +NH CLVFEML NLYD L+ F + L R QQ+ TAL+ L +
Sbjct: 249 YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS 308
Query: 270 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 326
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR+PE++LG
Sbjct: 309 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 366
Query: 327 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 386
+P+ AIDMWSLGC++ E+ G PL+ GA+E DQ+ I + G+P ++L K +FF
Sbjct: 367 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 426
Query: 387 EKLPD---GTWNLKKTKDGKRE--YKPPGTRK-LHNIL------GVETGGPGGRRAGESG 434
+ P+ W LK ++ + E K RK + N L + T G E
Sbjct: 427 NRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEK- 485
Query: 435 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKT 473
AD ++ DL+ +ML D RI P L H F T
Sbjct: 486 ---ADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMT 521
>gi|38201638 homeodomain-interacting protein kinase 1 isoform 2
[Homo sapiens]
Length = 1075
Score = 221 bits (564), Expect = 1e-57
Identities = 131/339 (38%), Positives = 191/339 (56%), Gaps = 22/339 (6%)
Query: 150 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 209
YE+ +G+G+FGQV K + R +E VAIKI+KN ++ Q QIEV +L ++ + + +
Sbjct: 190 YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENAD-E 248
Query: 210 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 269
Y V F +NH CLVFEML NLYD L+ F + L R QQ+ TAL+ L +
Sbjct: 249 YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS 308
Query: 270 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 326
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR+PE++LG
Sbjct: 309 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 366
Query: 327 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 386
+P+ AIDMWSLGC++ E+ G PL+ GA+E DQ+ I + G+P ++L K +FF
Sbjct: 367 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 426
Query: 387 EKLPD---GTWNLKKTKDGKRE--YKPPGTRK-LHNIL------GVETGGPGGRRAGESG 434
+ P+ W LK ++ + E K RK + N L + T G E
Sbjct: 427 NRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEK- 485
Query: 435 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKT 473
AD ++ DL+ +ML D RI P L H F T
Sbjct: 486 ---ADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMT 521
>gi|114796630 homeodomain interacting protein kinase 3 isoform 2
[Homo sapiens]
Length = 1194
Score = 215 bits (548), Expect = 1e-55
Identities = 133/335 (39%), Positives = 188/335 (56%), Gaps = 22/335 (6%)
Query: 150 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 209
YE+ +G+G+FGQVVK + R E VAIKI+KN ++ Q QIEV +L ++ + + +
Sbjct: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENAD-E 255
Query: 210 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 269
Y V F RNH CLVFEML NLYD L+ F + L + R QQ+ TAL L +
Sbjct: 256 YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS 315
Query: 270 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 326
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR+PE++LG
Sbjct: 316 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILG 373
Query: 327 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 386
+P+ AIDMWSLGC++ E+ G PL+ GA E DQ+ I + G+P +L+ K+ +FF
Sbjct: 374 LPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFF 433
Query: 387 EKLPD---GTWNLKKTKDGKRE--YKPPGTRK-----LHNILGVET--GGPGGRRAGESG 434
K D W LK ++ + E K RK L ++ V T G E
Sbjct: 434 CKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEK- 492
Query: 435 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSF 469
AD +F L+ +ML D RI P L H F
Sbjct: 493 ---ADRREFVSLLKKMLLIDADLRITPAETLNHPF 524
>gi|114796624 homeodomain interacting protein kinase 3 isoform 1
[Homo sapiens]
Length = 1215
Score = 215 bits (548), Expect = 1e-55
Identities = 133/335 (39%), Positives = 188/335 (56%), Gaps = 22/335 (6%)
Query: 150 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 209
YE+ +G+G+FGQVVK + R E VAIKI+KN ++ Q QIEV +L ++ + + +
Sbjct: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENAD-E 255
Query: 210 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 269
Y V F RNH CLVFEML NLYD L+ F + L + R QQ+ TAL L +
Sbjct: 256 YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS 315
Query: 270 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 326
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR+PE++LG
Sbjct: 316 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILG 373
Query: 327 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 386
+P+ AIDMWSLGC++ E+ G PL+ GA E DQ+ I + G+P +L+ K+ +FF
Sbjct: 374 LPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFF 433
Query: 387 EKLPD---GTWNLKKTKDGKRE--YKPPGTRK-----LHNILGVET--GGPGGRRAGESG 434
K D W LK ++ + E K RK L ++ V T G E
Sbjct: 434 CKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEK- 492
Query: 435 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSF 469
AD +F L+ +ML D RI P L H F
Sbjct: 493 ---ADRREFVSLLKKMLLIDADLRITPAETLNHPF 524
>gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens]
Length = 616
Score = 200 bits (508), Expect = 5e-51
Identities = 129/341 (37%), Positives = 183/341 (53%), Gaps = 22/341 (6%)
Query: 148 DRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE 207
D Y+I ++GKG+FG+V K + R E VAIKI+KN + E++LL M D E
Sbjct: 9 DCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPE 68
Query: 208 MKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFL 267
+ +++ F LVFE+L NL++ + NF + R Q+ TAL L
Sbjct: 69 -EAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARL 127
Query: 268 ATPELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIY---QYIQSRFYRSPE 322
EL+IIH DLKPENI+L + R +K++DFGS+ + Y YIQSRFYR+PE
Sbjct: 128 K--ELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPE 185
Query: 323 VLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKA 382
+LLG+P+ +D+WSLGC++ E+H G PL+ G NE DQ+ I E G+P H+L A KA
Sbjct: 186 ILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKA 245
Query: 383 RKFFEKLPD----GTWNLKKTKD--GKREYKPPGTRK-----LHNILGVETGGPGGRRAG 431
FF++ P W LK + D + + +P RK L I V G R
Sbjct: 246 HHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTF 305
Query: 432 ESGHTVADYLKFK---DLILRMLDYDPKTRIQPYYALQHSF 469
+A++ K +LI RML ++ RI P AL+H F
Sbjct: 306 PDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPF 346
>gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens]
Length = 638
Score = 177 bits (450), Expect = 2e-44
Identities = 128/460 (27%), Positives = 218/460 (47%), Gaps = 63/460 (13%)
Query: 33 QMPHSHQYSDRRQPNISDQQVSALSYSDQIQQPLTNQRRMPQTFRDPATAPLRKLSVDLI 92
++P+ +Y +RR + + + S+ + P ++ R R P
Sbjct: 202 RLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGP------------Y 249
Query: 93 KTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWM-DRYE 151
+T KH + + KRR + S ++ K + +DD ++V W+ +RYE
Sbjct: 250 RTRKHAHHCH----KRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYE 305
Query: 152 IDSLIGKGSFGQVVKAYDRVE-QEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKY 210
I +G+G+FG+VV+ D + VA+KII+N + A++E+ +L+ + + D E K+
Sbjct: 306 IVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKF 365
Query: 211 YIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATP 270
V + F F H+C+ FE+L N ++ L+ NF+ L R A Q+C AL FL
Sbjct: 366 LCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHEN 425
Query: 271 ELSIIHCDLKPENILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYI 313
+L+ H DLKPENIL N K ++I++ DFGS+ + +
Sbjct: 426 QLT--HTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIV 483
Query: 314 QSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPA 373
+R YR PEV+L + + D+WS+GCIL E + G LF + + + ++LG P+
Sbjct: 484 ATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPS 543
Query: 374 HILDQAPKARKFFEKLPDGTWNLKKTKDG---KREYKPPGTRKLHNILGVETGGPGGRRA 430
H++ + K + F++ W+ + + DG K KP + L + L
Sbjct: 544 HMIHRTRKQKYFYK--GGLVWD-ENSSDGRYVKENCKPLKSYMLQDSL------------ 588
Query: 431 GESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 470
++++ DL+ RML++DP RI AL H FF
Sbjct: 589 --------EHVQLFDLMRRMLEFDPAQRITLAEALLHPFF 620
>gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens]
Length = 490
Score = 177 bits (450), Expect = 2e-44
Identities = 128/460 (27%), Positives = 218/460 (47%), Gaps = 63/460 (13%)
Query: 33 QMPHSHQYSDRRQPNISDQQVSALSYSDQIQQPLTNQRRMPQTFRDPATAPLRKLSVDLI 92
++P+ +Y +RR + + + S+ + P ++ R R P
Sbjct: 54 RLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGP------------Y 101
Query: 93 KTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWM-DRYE 151
+T KH + + KRR + S ++ K + +DD ++V W+ +RYE
Sbjct: 102 RTRKHAHHCH----KRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYE 157
Query: 152 IDSLIGKGSFGQVVKAYDRVE-QEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKY 210
I +G+G+FG+VV+ D + VA+KII+N + A++E+ +L+ + + D E K+
Sbjct: 158 IVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKF 217
Query: 211 YIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATP 270
V + F F H+C+ FE+L N ++ L+ NF+ L R A Q+C AL FL
Sbjct: 218 LCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHEN 277
Query: 271 ELSIIHCDLKPENILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYI 313
+L+ H DLKPENIL N K ++I++ DFGS+ + +
Sbjct: 278 QLT--HTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIV 335
Query: 314 QSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPA 373
+R YR PEV+L + + D+WS+GCIL E + G LF + + + ++LG P+
Sbjct: 336 ATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPS 395
Query: 374 HILDQAPKARKFFEKLPDGTWNLKKTKDG---KREYKPPGTRKLHNILGVETGGPGGRRA 430
H++ + K + F++ W+ + + DG K KP + L + L
Sbjct: 396 HMIHRTRKQKYFYK--GGLVWD-ENSSDGRYVKENCKPLKSYMLQDSL------------ 440
Query: 431 GESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 470
++++ DL+ RML++DP RI AL H FF
Sbjct: 441 --------EHVQLFDLMRRMLEFDPAQRITLAEALLHPFF 472
>gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens]
Length = 526
Score = 172 bits (435), Expect = 1e-42
Identities = 116/395 (29%), Positives = 190/395 (48%), Gaps = 47/395 (11%)
Query: 94 TYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEID 153
+YK + ++++ H++ G K+ R V DD+ I ++G+ RYEI
Sbjct: 154 SYKSKHRIHHSTS---HRRSHGKSHRRKRTRSVE----DDEEGHLICQSGDVLSARYEIV 206
Query: 154 SLIGKGSFGQVVKAYD-RVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYI 212
+G+G+FG+VV+ D + VA+KI+KN + A+ E+++LE +N D +
Sbjct: 207 DTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRC 266
Query: 213 VHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPEL 272
V + F H+C+VFE+L + YD ++ F L+ RK A Q+C ++ FL + +L
Sbjct: 267 VQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKL 326
Query: 273 SIIHCDLKPENILLC--------NPK---------RSAIKIVDFGSSCQLGQRIYQYIQS 315
+ H DLKPENIL NPK IK+VDFGS+ + + +
Sbjct: 327 T--HTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVST 384
Query: 316 RFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHI 375
R YR+PEV+L + + D+WS+GCIL+E + G +F + + + + +LG P H+
Sbjct: 385 RHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHM 444
Query: 376 LDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGH 435
+ + K + F D + + R KP L +
Sbjct: 445 IQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDV----------------- 487
Query: 436 TVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 470
++ + DLI +ML+YDP RI AL+H FF
Sbjct: 488 ---EHERLFDLIQKMLEYDPAKRITLREALKHPFF 519
>gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]
Length = 484
Score = 172 bits (435), Expect = 1e-42
Identities = 116/395 (29%), Positives = 190/395 (48%), Gaps = 47/395 (11%)
Query: 94 TYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEID 153
+YK + ++++ H++ G K+ R V DD+ I ++G+ RYEI
Sbjct: 112 SYKSKHRIHHSTS---HRRSHGKSHRRKRTRSVE----DDEEGHLICQSGDVLSARYEIV 164
Query: 154 SLIGKGSFGQVVKAYD-RVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYI 212
+G+G+FG+VV+ D + VA+KI+KN + A+ E+++LE +N D +
Sbjct: 165 DTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRC 224
Query: 213 VHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPEL 272
V + F H+C+VFE+L + YD ++ F L+ RK A Q+C ++ FL + +L
Sbjct: 225 VQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKL 284
Query: 273 SIIHCDLKPENILLC--------NPK---------RSAIKIVDFGSSCQLGQRIYQYIQS 315
+ H DLKPENIL NPK IK+VDFGS+ + + +
Sbjct: 285 T--HTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVST 342
Query: 316 RFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHI 375
R YR+PEV+L + + D+WS+GCIL+E + G +F + + + + +LG P H+
Sbjct: 343 RHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHM 402
Query: 376 LDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGH 435
+ + K + F D + + R KP L +
Sbjct: 403 IQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDV----------------- 445
Query: 436 TVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 470
++ + DLI +ML+YDP RI AL+H FF
Sbjct: 446 ---EHERLFDLIQKMLEYDPAKRITLREALKHPFF 477
>gi|10190706 CDC-like kinase 4 [Homo sapiens]
Length = 481
Score = 172 bits (435), Expect = 1e-42
Identities = 112/385 (29%), Positives = 189/385 (49%), Gaps = 43/385 (11%)
Query: 106 KKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIV-KNGEKWMDRYEIDSLIGKGSFGQV 164
K++R++ S K R+ + +DD +++ ++G+ RYEI +G+G+FG+V
Sbjct: 114 KRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKV 173
Query: 165 VKAYDR-VEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRN 223
V+ D ++ VA+KI+KN + A+ E+++LE +N D + V + F
Sbjct: 174 VECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHG 233
Query: 224 HLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPEN 283
H+C+VFE+L + YD ++ +F ++ R+ A Q+C ++ FL +L+ H DLKPEN
Sbjct: 234 HVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLT--HTDLKPEN 291
Query: 284 ILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLG 326
IL K + IK+VDFGS+ + + +R YR+PEV+L
Sbjct: 292 ILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILA 351
Query: 327 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 386
+ + D+WS+GCIL+E + G +F + + + + +LG P H++ + K + F
Sbjct: 352 LGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFH 411
Query: 387 EKLPDGTWNLKKTKDGKREYKPPGTRKL-HNILGVETGGPGGRRAGESGHTVADYLKFKD 445
D + + +R KP L H+ ++ K D
Sbjct: 412 HNQLDWDEHSSAGRYVRRRCKPLKEFMLCHD---------------------EEHEKLFD 450
Query: 446 LILRMLDYDPKTRIQPYYALQHSFF 470
L+ RML+YDP RI ALQH FF
Sbjct: 451 LVRRMLEYDPTQRITLDEALQHPFF 475
>gi|47717134 CDC-like kinase 2 [Homo sapiens]
Length = 498
Score = 171 bits (434), Expect = 2e-42
Identities = 117/394 (29%), Positives = 197/394 (50%), Gaps = 44/394 (11%)
Query: 105 KKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWM-DRYEIDSLIGKGSFGQ 163
+++RR + SSH R +DD +++ + W+ +RYEI S +G+G+FG+
Sbjct: 119 RRRRRRSRTFSRSSSHSSRRA---KSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGR 175
Query: 164 VVKAYD-RVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFR 222
VV+ D R VA+KIIKN + + A++E+ +LE +N+ D + K V + F +
Sbjct: 176 VVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYH 235
Query: 223 NHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPE 282
H+C+ FE+L + +D L++ N+ ++ R A Q+C A+ FL +L+ H DLKPE
Sbjct: 236 GHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLT--HTDLKPE 293
Query: 283 NILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLL 325
NIL N K +A+++VDFGS+ + + +R YR+PEV+L
Sbjct: 294 NILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVIL 353
Query: 326 GMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKF 385
+ + D+WS+GCI+ E + G LF + + + + +LG P+ ++ + K + F
Sbjct: 354 ELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYF 413
Query: 386 FEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKD 445
+ D W+ + T G+ Y + L L E ++ + D
Sbjct: 414 YRGRLD--WD-ENTSAGR--YVRENCKPLRRYLTSE---------------AEEHHQLFD 453
Query: 446 LILRMLDYDPKTRIQPYYALQHSFFKKTADEGTN 479
LI ML+Y+P R+ ALQH FF + E N
Sbjct: 454 LIESMLEYEPAKRLTLGEALQHPFFARLRAEPPN 487
>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
Length = 1007
Score = 169 bits (429), Expect = 7e-42
Identities = 123/374 (32%), Positives = 191/374 (51%), Gaps = 15/374 (4%)
Query: 103 YAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFG 162
Y R G G D KE D + D Y V GE RY + G+G F
Sbjct: 643 YFDSARLRAAGIGKDF---KENPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFS 699
Query: 163 QVVKAYD--RVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFM 220
VV+A D R QE VA+KII+N + E+ L+ +N D + K++ + L RHF
Sbjct: 700 NVVRARDNARANQE-VAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFY 758
Query: 221 FRNHLCLVFEMLSYNLYDLLRNTNFR-GVSLNLTRKFAQQMCTALLFLATPELSIIHCDL 279
+ HLCLVFE LS NL ++L+ G+ + R ++QQ+ AL L +I+H D+
Sbjct: 759 HKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLK--RCNILHADI 816
Query: 280 KPENILLCNPKRSAIKIVDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGMPYDLAIDMWSL 338
KP+NIL+ N ++ +K+ DFGS+ + I Y+ SRFYR+PE+++G YD IDMWS+
Sbjct: 817 KPDNILV-NESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSV 875
Query: 339 GCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKK 398
GC L E++TG+ LF G + +++ G P ++ + + F++ + + ++
Sbjct: 876 GCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMY-IEV 934
Query: 399 TKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTR 458
K +RE K ++ + G +R E L KDL+ ++L DP R
Sbjct: 935 DKVTERE-KVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQL--KDLLDQILMLDPAKR 991
Query: 459 IQPYYALQHSFFKK 472
I ALQH+F ++
Sbjct: 992 ISINQALQHAFIQE 1005
>gi|169171014 PREDICTED: similar to homeodomain interacting protein
kinase 2 [Homo sapiens]
Length = 460
Score = 137 bits (345), Expect = 4e-32
Identities = 75/173 (43%), Positives = 105/173 (60%), Gaps = 6/173 (3%)
Query: 150 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 209
YE+ +G+G+FGQVVK + R E VAIKI+KN ++ Q QIEV +L ++ +
Sbjct: 199 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESAD-D 257
Query: 210 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 269
Y V F +NH CLVFEML NLYD L+ F + L R QQ+ TAL+ L +
Sbjct: 258 YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS 317
Query: 270 PELSIIHCDLKPENILLCNPKRS--AIKIVDFGSSCQLGQRIYQ-YIQSRFYR 319
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR
Sbjct: 318 --LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYR 368
>gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens]
Length = 1030
Score = 134 bits (338), Expect = 2e-31
Identities = 82/231 (35%), Positives = 133/231 (57%), Gaps = 12/231 (5%)
Query: 147 MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDT 206
M+++EI ++G+G++G V+K + E VAIK K+ + + +R L+++ T
Sbjct: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLR---T 66
Query: 207 EMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLF 266
+ IV LK F R L LVFE + N+ +LL GV + + Q+ A+ +
Sbjct: 67 LKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMP-NGVPPEKVKSYIYQLIKAIHW 125
Query: 267 LATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQ----RIYQYIQSRFYRSPE 322
+ I+H D+KPEN+L+ + +K+ DFG + L + +Y+ +R+YRSPE
Sbjct: 126 CHKND--IVHRDIKPENLLISH--NDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPE 181
Query: 323 VLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPA 373
+LLG PY ++DMWS+GCIL E+ G+PLF G +E+DQ+ I +VLG P+
Sbjct: 182 LLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPS 232
>gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens]
Length = 1030
Score = 134 bits (338), Expect = 2e-31
Identities = 82/231 (35%), Positives = 133/231 (57%), Gaps = 12/231 (5%)
Query: 147 MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDT 206
M+++EI ++G+G++G V+K + E VAIK K+ + + +R L+++ T
Sbjct: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLR---T 66
Query: 207 EMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLF 266
+ IV LK F R L LVFE + N+ +LL GV + + Q+ A+ +
Sbjct: 67 LKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMP-NGVPPEKVKSYIYQLIKAIHW 125
Query: 267 LATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQ----RIYQYIQSRFYRSPE 322
+ I+H D+KPEN+L+ + +K+ DFG + L + +Y+ +R+YRSPE
Sbjct: 126 CHKND--IVHRDIKPENLLISH--NDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPE 181
Query: 323 VLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPA 373
+LLG PY ++DMWS+GCIL E+ G+PLF G +E+DQ+ I +VLG P+
Sbjct: 182 LLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPS 232
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.129 0.386
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,859,249
Number of Sequences: 37866
Number of extensions: 1500561
Number of successful extensions: 16659
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 637
Number of HSP's successfully gapped in prelim test: 402
Number of HSP's that attempted gapping in prelim test: 8580
Number of HSP's gapped (non-prelim): 4260
length of query: 754
length of database: 18,247,518
effective HSP length: 110
effective length of query: 644
effective length of database: 14,082,258
effective search space: 9068974152
effective search space used: 9068974152
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.