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Search of human proteins with 186928858
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|186928858 solute carrier family 25, member 19 [Homo sapiens]
(320 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|186928856 solute carrier family 25, member 19 [Homo sapiens] 649 0.0
gi|186928860 solute carrier family 25, member 19 [Homo sapiens] 649 0.0
gi|186928858 solute carrier family 25, member 19 [Homo sapiens] 649 0.0
gi|27544933 solute carrier family 25, member 16 [Homo sapiens] 126 2e-29
gi|60460887 solute carrier family 25, member 42 [Homo sapiens] 118 8e-27
gi|239755176 PREDICTED: similar to solute carrier family 25, mem... 115 7e-26
gi|239755174 PREDICTED: similar to solute carrier family 25, mem... 115 7e-26
gi|56699407 solute carrier family 25, member 25 isoform c [Homo ... 115 7e-26
gi|56699401 solute carrier family 25, member 25 isoform a [Homo ... 115 7e-26
gi|56699405 solute carrier family 25, member 25 isoform d [Homo ... 115 7e-26
gi|56699403 solute carrier family 25, member 25 isoform b [Homo ... 115 7e-26
gi|48476342 solute carrier family 25, member 23 [Homo sapiens] 110 2e-24
gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo ... 109 3e-24
gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo s... 109 3e-24
gi|21687151 mitochondrial solute carrier protein [Homo sapiens] 105 7e-23
gi|116235462 solute carrier family 25, member 45 isoform a [Homo... 99 7e-21
gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Ho... 96 3e-20
gi|13259543 solute carrier family 25, member 14 isoform UCP5S [H... 96 3e-20
gi|13775208 solute carrier family 25 (mitochondrial carrier; ade... 94 2e-19
gi|46094065 mitochondrial carrier family protein [Homo sapiens] 93 3e-19
gi|13259541 uncoupling protein 2 [Homo sapiens] 92 6e-19
gi|149274643 solute carrier family 25, member 28 [Homo sapiens] 92 6e-19
gi|21389315 solute carrier family 25 (mitochondrial carrier; cit... 91 1e-18
gi|86198310 solute carrier family 25, member 29 [Homo sapiens] 91 1e-18
gi|58197562 solute carrier family 25, member 30 [Homo sapiens] 91 2e-18
gi|156071459 solute carrier family 25, member 5 [Homo sapiens] 91 2e-18
gi|6031192 solute carrier family 25 member 3 isoform a precursor... 89 5e-18
gi|4507807 uncoupling protein 3 isoform UCP3L [Homo sapiens] 89 5e-18
gi|7657585 mitochondrial ornithine transporter 1 [Homo sapiens] 89 7e-18
gi|4505775 solute carrier family 25 member 3 isoform b precursor... 89 7e-18
>gi|186928856 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 649 bits (1674), Expect = 0.0
Identities = 320/320 (100%), Positives = 320/320 (100%)
Query: 1 MVGYDPKPDGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYH 60
MVGYDPKPDGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYH
Sbjct: 1 MVGYDPKPDGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYH 60
Query: 61 GILQASRQILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSV 120
GILQASRQILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSV
Sbjct: 61 GILQASRQILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSV 120
Query: 121 HFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAP 180
HFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAP
Sbjct: 121 HFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAP 180
Query: 181 TLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLF 240
TLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLF
Sbjct: 181 TLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLF 240
Query: 241 KKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMF 300
KKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMF
Sbjct: 241 KKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMF 300
Query: 301 FSYEFFCNVFHCMNRTASQR 320
FSYEFFCNVFHCMNRTASQR
Sbjct: 301 FSYEFFCNVFHCMNRTASQR 320
>gi|186928860 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 649 bits (1674), Expect = 0.0
Identities = 320/320 (100%), Positives = 320/320 (100%)
Query: 1 MVGYDPKPDGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYH 60
MVGYDPKPDGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYH
Sbjct: 1 MVGYDPKPDGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYH 60
Query: 61 GILQASRQILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSV 120
GILQASRQILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSV
Sbjct: 61 GILQASRQILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSV 120
Query: 121 HFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAP 180
HFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAP
Sbjct: 121 HFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAP 180
Query: 181 TLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLF 240
TLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLF
Sbjct: 181 TLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLF 240
Query: 241 KKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMF 300
KKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMF
Sbjct: 241 KKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMF 300
Query: 301 FSYEFFCNVFHCMNRTASQR 320
FSYEFFCNVFHCMNRTASQR
Sbjct: 301 FSYEFFCNVFHCMNRTASQR 320
>gi|186928858 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 649 bits (1674), Expect = 0.0
Identities = 320/320 (100%), Positives = 320/320 (100%)
Query: 1 MVGYDPKPDGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYH 60
MVGYDPKPDGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYH
Sbjct: 1 MVGYDPKPDGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYH 60
Query: 61 GILQASRQILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSV 120
GILQASRQILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSV
Sbjct: 61 GILQASRQILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSV 120
Query: 121 HFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAP 180
HFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAP
Sbjct: 121 HFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAP 180
Query: 181 TLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLF 240
TLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLF
Sbjct: 181 TLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLF 240
Query: 241 KKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMF 300
KKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMF
Sbjct: 241 KKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMF 300
Query: 301 FSYEFFCNVFHCMNRTASQR 320
FSYEFFCNVFHCMNRTASQR
Sbjct: 301 FSYEFFCNVFHCMNRTASQR 320
>gi|27544933 solute carrier family 25, member 16 [Homo sapiens]
Length = 332
Score = 126 bits (317), Expect = 2e-29
Identities = 91/311 (29%), Positives = 148/311 (47%), Gaps = 40/311 (12%)
Query: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
+AG ++G + ++P D +K+ Q + K+ G+ A R + Q+EG +
Sbjct: 41 LAGGIAGCCAKTTVAPLDRVKVLLQAHNHHY-------KHLGVFSALRAVPQKEGFLGLY 93
Query: 80 KGHVPAQILSIGYGAVQFLSFE-----MLTELVHRGSVYDAREFSVHFVCGGLAACMATL 134
KG+ I YGA+QF++FE + T+L G V+ + G +A A +
Sbjct: 94 KGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVH-------RLMAGSMAGMTAVI 146
Query: 135 TVHPVDVLRTRFAAQ--GEPKVYNTLRHAVGTMYRSEGPQV-FYKGLAPTLIAIFPYAGL 191
+P+D++R R A Q GE Y + HA T+Y EG FY+GL PT++ + PYAG+
Sbjct: 147 CTYPLDMVRVRLAFQVKGEHS-YTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGV 205
Query: 192 QFSCYSSLKHLYKWAIPA----EGKKNENLQ------NLLCGSGAGVISKTLTYPLDLFK 241
F + +LK + P N N+ NLLCG AG I++T++YP D+ +
Sbjct: 206 SFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDVTR 265
Query: 242 KRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEG-ALGFFKGLSPSLLKAALSTGFMF 300
+R+Q+G + + + D K V G G ++GLS + ++ S F
Sbjct: 266 RRMQLG------TVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAF 319
Query: 301 FSYEFFCNVFH 311
+YE FH
Sbjct: 320 TTYELMKQFFH 330
Score = 87.8 bits (216), Expect = 1e-17
Identities = 60/185 (32%), Positives = 91/185 (49%), Gaps = 17/185 (9%)
Query: 122 FVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPT 181
F+ GG+A C A TV P+D ++ A + + A+ + + EG YKG
Sbjct: 40 FLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGVFSALRAVPQKEGFLGLYKGNGAM 99
Query: 182 LIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFK 241
+I IFPY +QF + K L + G ++ L+ GS AG+ + TYPLD+ +
Sbjct: 100 MIRIFPYGAIQFMAFEHYKTLITTKLGISG----HVHRLMAGSMAGMTAVICTYPLDMVR 155
Query: 242 KRL--QVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGA-LGFFKGLSPSLLKAALSTGF 298
RL QV G EH+ Y G++ K + KEG GF++GL P++L A G
Sbjct: 156 VRLAFQVKG-EHS---------YTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGV 205
Query: 299 MFFSY 303
FF++
Sbjct: 206 SFFTF 210
Score = 40.0 bits (92), Expect = 0.003
Identities = 25/90 (27%), Positives = 40/90 (44%), Gaps = 9/90 (10%)
Query: 217 LQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKE 276
L++ L G AG +KT PLD K LQ + ++ G+ + V QKE
Sbjct: 37 LRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHY---------KHLGVFSALRAVPQKE 87
Query: 277 GALGFFKGLSPSLLKAALSTGFMFFSYEFF 306
G LG +KG +++ F ++E +
Sbjct: 88 GFLGLYKGNGAMMIRIFPYGAIQFMAFEHY 117
>gi|60460887 solute carrier family 25, member 42 [Homo sapiens]
Length = 318
Score = 118 bits (295), Expect = 8e-27
Identities = 79/291 (27%), Positives = 148/291 (50%), Gaps = 31/291 (10%)
Query: 22 GSVSGLVTRALISPFDVIKIRFQLQHERLSRSDP-SAKYHGILQASRQILQEEGPTAFWK 80
G+++G + + ++P D KI FQ+ +R S + Y+ L EG + W+
Sbjct: 40 GALAGALAKTAVAPLDRTKIIFQVSSKRFSAKEAFRVLYYTYLN--------EGFLSLWR 91
Query: 81 GHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSV----HFVCGGLAACMATLTV 136
G+ + + Y A+QF + E ++ GS Y R ++ G LA A
Sbjct: 92 GNSATMVRVVPYAAIQFSAHEEYKRIL--GSYYGFRGEALPPWPRLFAGALAGTTAASLT 149
Query: 137 HPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCY 196
+P+D++R R A + ++Y+ + H + R EG + Y G PT++ + PYAGL F Y
Sbjct: 150 YPLDLVRARMAVTPK-EMYSNIFHVFIRISREEGLKTLYHGFMPTVLGVIPYAGLSFFTY 208
Query: 197 SSLKHLYKWAIPAEGKKNE-NLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFE-HARA 254
+LK L++ G++ + ++ G+ AG+I ++ +YPLD+ ++R+Q G + RA
Sbjct: 209 ETLKSLHR---EYSGRRQPYPFERMIFGACAGLIGQSASYPLDVVRRRMQTAGVTGYPRA 265
Query: 255 AFGQVRRYKGLMDCAKQVLQKEGAL-GFFKGLSPSLLKAALSTGFMFFSYE 304
+ + R ++++EGA+ G +KGLS + +K ++ G F +++
Sbjct: 266 SIARTLR---------TIVREEGAVRGLYKGLSMNWVKGPIAVGISFTTFD 307
Score = 52.8 bits (125), Expect = 4e-07
Identities = 51/195 (26%), Positives = 81/195 (41%), Gaps = 28/195 (14%)
Query: 21 AGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFWK 80
AG+++G +L P D+++ R + P Y I +I +EEG +
Sbjct: 137 AGALAGTTAASLTYPLDLVRARMAV--------TPKEMYSNIFHVFIRISREEGLKTLYH 188
Query: 81 GHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHF---VCGGLAACMATLTVH 137
G +P + I Y + F ++E L L HR Y R F + G A + +
Sbjct: 189 GFMPTVLGVIPYAGLSFFTYETLKSL-HR--EYSGRRQPYPFERMIFGACAGLIGQSASY 245
Query: 138 PVDVLRTRFAAQG-----EPKVYNTLRHAVGTMYRSEGP-QVFYKGLAPTLIAIFPYAGL 191
P+DV+R R G + TLR T+ R EG + YKGL+ + G+
Sbjct: 246 PLDVVRRRMQTAGVTGYPRASIARTLR----TIVREEGAVRGLYKGLSMNWVKGPIAVGI 301
Query: 192 QFSCYS----SLKHL 202
F+ + L+HL
Sbjct: 302 SFTTFDLMQIMLRHL 316
Score = 30.0 bits (66), Expect = 2.9
Identities = 24/88 (27%), Positives = 38/88 (43%), Gaps = 9/88 (10%)
Query: 217 LQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKE 276
L +LL G+ AG ++KT PLD K QV + +V Y L E
Sbjct: 34 LSSLLPGALAGALAKTAVAPLDRTKIIFQVSSKRFSAKEAFRVLYYTYL---------NE 84
Query: 277 GALGFFKGLSPSLLKAALSTGFMFFSYE 304
G L ++G S ++++ F ++E
Sbjct: 85 GFLSLWRGNSATMVRVVPYAAIQFSAHE 112
>gi|239755176 PREDICTED: similar to solute carrier family 25, member
25 isoform 2 [Homo sapiens]
Length = 469
Score = 115 bits (287), Expect = 7e-26
Identities = 75/285 (26%), Positives = 134/285 (47%), Gaps = 17/285 (5%)
Query: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
VAG +G V+R +P D +K+ Q+ R + GI+ Q+++E G + W
Sbjct: 191 VAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNM-------GIVGGFTQMIREGGARSLW 243
Query: 80 KGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPV 139
+G+ + A++F+++E + LV GS + V G LA +A +++P+
Sbjct: 244 RGNGINVLKIAPESAIKFMAYEQIKRLV--GSDQETLRIHERLVAGSLAGAIAQSSIYPM 301
Query: 140 DVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSL 199
+VL+TR A + + Y+ + + EG FYKG P ++ I PYAG+ + Y +L
Sbjct: 302 EVLKTRMALRKTGQ-YSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETL 360
Query: 200 KHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQV 259
K+ + L CG+ + + +YPL L + R+Q A+A+
Sbjct: 361 KNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQ------AQASIEGA 414
Query: 260 RRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
+ K +L+ EGA G ++GL+P+ +K + + YE
Sbjct: 415 PEVT-MSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYE 458
Score = 85.9 bits (211), Expect = 4e-17
Identities = 57/187 (30%), Positives = 92/187 (49%), Gaps = 16/187 (8%)
Query: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
VAGS++G + ++ I P +V+K R L+ + +Y G+L +R+IL EG AF+
Sbjct: 285 VAGSLAGAIAQSSIYPMEVLKTRMALRK--------TGQYSGMLDCARRILAREGVAAFY 336
Query: 80 KGHVPAQILSIGYGAVQFLSFEMLTE--LVHRGSVYDAREFSVHFVCGGLAACMATLTVH 137
KG+VP + I Y + +E L L H V CG +++ L +
Sbjct: 337 KGYVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASY 396
Query: 138 PVDVLRTRFAAQ----GEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQF 193
P+ ++RTR AQ G P+V T+ + R+EG Y+GLAP + + P + +
Sbjct: 397 PLALVRTRMQAQASIEGAPEV--TMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISY 454
Query: 194 SCYSSLK 200
Y +LK
Sbjct: 455 VVYENLK 461
Score = 73.6 bits (179), Expect = 2e-13
Identities = 49/193 (25%), Positives = 84/193 (43%), Gaps = 20/193 (10%)
Query: 121 HFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAP 180
H V GG A ++ P+D L+ + M R G + ++G
Sbjct: 189 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGI 248
Query: 181 TLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENL---QNLLCGSGAGVISKTLTYPL 237
++ I P + ++F Y +K L G E L + L+ GS AG I+++ YP+
Sbjct: 249 NVLKIAPESAIKFMAYEQIKRLV-------GSDQETLRIHERLVAGSLAGAIAQSSIYPM 301
Query: 238 DLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTG 297
++ K R+ A + +Y G++DCA+++L +EG F+KG P++L G
Sbjct: 302 EVLKTRM----------ALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAG 351
Query: 298 FMFFSYEFFCNVF 310
YE N +
Sbjct: 352 IDLAVYETLKNAW 364
Score = 43.1 bits (100), Expect = 3e-04
Identities = 27/87 (31%), Positives = 46/87 (52%), Gaps = 9/87 (10%)
Query: 218 QNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEG 277
++L+ G GAG +S+T T PLD K +QV HA + G++ Q++++ G
Sbjct: 188 RHLVAGGGAGAVSRTCTAPLDRLKVLMQV----HASRS-----NNMGIVGGFTQMIREGG 238
Query: 278 ALGFFKGLSPSLLKAALSTGFMFFSYE 304
A ++G ++LK A + F +YE
Sbjct: 239 ARSLWRGNGINVLKIAPESAIKFMAYE 265
>gi|239755174 PREDICTED: similar to solute carrier family 25, member
25 isoform 1 [Homo sapiens]
Length = 503
Score = 115 bits (287), Expect = 7e-26
Identities = 75/285 (26%), Positives = 134/285 (47%), Gaps = 17/285 (5%)
Query: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
VAG +G V+R +P D +K+ Q+ R + GI+ Q+++E G + W
Sbjct: 225 VAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNM-------GIVGGFTQMIREGGARSLW 277
Query: 80 KGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPV 139
+G+ + A++F+++E + LV GS + V G LA +A +++P+
Sbjct: 278 RGNGINVLKIAPESAIKFMAYEQIKRLV--GSDQETLRIHERLVAGSLAGAIAQSSIYPM 335
Query: 140 DVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSL 199
+VL+TR A + + Y+ + + EG FYKG P ++ I PYAG+ + Y +L
Sbjct: 336 EVLKTRMALRKTGQ-YSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETL 394
Query: 200 KHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQV 259
K+ + L CG+ + + +YPL L + R+Q A+A+
Sbjct: 395 KNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQ------AQASIEGA 448
Query: 260 RRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
+ K +L+ EGA G ++GL+P+ +K + + YE
Sbjct: 449 PEVT-MSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYE 492
Score = 85.9 bits (211), Expect = 4e-17
Identities = 57/187 (30%), Positives = 92/187 (49%), Gaps = 16/187 (8%)
Query: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
VAGS++G + ++ I P +V+K R L+ + +Y G+L +R+IL EG AF+
Sbjct: 319 VAGSLAGAIAQSSIYPMEVLKTRMALRK--------TGQYSGMLDCARRILAREGVAAFY 370
Query: 80 KGHVPAQILSIGYGAVQFLSFEMLTE--LVHRGSVYDAREFSVHFVCGGLAACMATLTVH 137
KG+VP + I Y + +E L L H V CG +++ L +
Sbjct: 371 KGYVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASY 430
Query: 138 PVDVLRTRFAAQ----GEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQF 193
P+ ++RTR AQ G P+V T+ + R+EG Y+GLAP + + P + +
Sbjct: 431 PLALVRTRMQAQASIEGAPEV--TMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISY 488
Query: 194 SCYSSLK 200
Y +LK
Sbjct: 489 VVYENLK 495
Score = 73.6 bits (179), Expect = 2e-13
Identities = 49/193 (25%), Positives = 84/193 (43%), Gaps = 20/193 (10%)
Query: 121 HFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAP 180
H V GG A ++ P+D L+ + M R G + ++G
Sbjct: 223 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGI 282
Query: 181 TLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENL---QNLLCGSGAGVISKTLTYPL 237
++ I P + ++F Y +K L G E L + L+ GS AG I+++ YP+
Sbjct: 283 NVLKIAPESAIKFMAYEQIKRLV-------GSDQETLRIHERLVAGSLAGAIAQSSIYPM 335
Query: 238 DLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTG 297
++ K R+ A + +Y G++DCA+++L +EG F+KG P++L G
Sbjct: 336 EVLKTRM----------ALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAG 385
Query: 298 FMFFSYEFFCNVF 310
YE N +
Sbjct: 386 IDLAVYETLKNAW 398
Score = 43.1 bits (100), Expect = 3e-04
Identities = 27/87 (31%), Positives = 46/87 (52%), Gaps = 9/87 (10%)
Query: 218 QNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEG 277
++L+ G GAG +S+T T PLD K +QV HA + G++ Q++++ G
Sbjct: 222 RHLVAGGGAGAVSRTCTAPLDRLKVLMQV----HASRS-----NNMGIVGGFTQMIREGG 272
Query: 278 ALGFFKGLSPSLLKAALSTGFMFFSYE 304
A ++G ++LK A + F +YE
Sbjct: 273 ARSLWRGNGINVLKIAPESAIKFMAYE 299
>gi|56699407 solute carrier family 25, member 25 isoform c [Homo
sapiens]
Length = 489
Score = 115 bits (287), Expect = 7e-26
Identities = 75/285 (26%), Positives = 134/285 (47%), Gaps = 17/285 (5%)
Query: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
VAG +G V+R +P D +K+ Q+ R + GI+ Q+++E G + W
Sbjct: 211 VAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNM-------GIVGGFTQMIREGGARSLW 263
Query: 80 KGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPV 139
+G+ + A++F+++E + LV GS + V G LA +A +++P+
Sbjct: 264 RGNGINVLKIAPESAIKFMAYEQIKRLV--GSDQETLRIHERLVAGSLAGAIAQSSIYPM 321
Query: 140 DVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSL 199
+VL+TR A + + Y+ + + EG FYKG P ++ I PYAG+ + Y +L
Sbjct: 322 EVLKTRMALRKTGQ-YSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETL 380
Query: 200 KHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQV 259
K+ + L CG+ + + +YPL L + R+Q A+A+
Sbjct: 381 KNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQ------AQASIEGA 434
Query: 260 RRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
+ K +L+ EGA G ++GL+P+ +K + + YE
Sbjct: 435 PEVT-MSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYE 478
Score = 85.9 bits (211), Expect = 4e-17
Identities = 57/187 (30%), Positives = 92/187 (49%), Gaps = 16/187 (8%)
Query: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
VAGS++G + ++ I P +V+K R L+ + +Y G+L +R+IL EG AF+
Sbjct: 305 VAGSLAGAIAQSSIYPMEVLKTRMALRK--------TGQYSGMLDCARRILAREGVAAFY 356
Query: 80 KGHVPAQILSIGYGAVQFLSFEMLTE--LVHRGSVYDAREFSVHFVCGGLAACMATLTVH 137
KG+VP + I Y + +E L L H V CG +++ L +
Sbjct: 357 KGYVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASY 416
Query: 138 PVDVLRTRFAAQ----GEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQF 193
P+ ++RTR AQ G P+V T+ + R+EG Y+GLAP + + P + +
Sbjct: 417 PLALVRTRMQAQASIEGAPEV--TMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISY 474
Query: 194 SCYSSLK 200
Y +LK
Sbjct: 475 VVYENLK 481
Score = 73.6 bits (179), Expect = 2e-13
Identities = 49/193 (25%), Positives = 84/193 (43%), Gaps = 20/193 (10%)
Query: 121 HFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAP 180
H V GG A ++ P+D L+ + M R G + ++G
Sbjct: 209 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGI 268
Query: 181 TLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENL---QNLLCGSGAGVISKTLTYPL 237
++ I P + ++F Y +K L G E L + L+ GS AG I+++ YP+
Sbjct: 269 NVLKIAPESAIKFMAYEQIKRLV-------GSDQETLRIHERLVAGSLAGAIAQSSIYPM 321
Query: 238 DLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTG 297
++ K R+ A + +Y G++DCA+++L +EG F+KG P++L G
Sbjct: 322 EVLKTRM----------ALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAG 371
Query: 298 FMFFSYEFFCNVF 310
YE N +
Sbjct: 372 IDLAVYETLKNAW 384
Score = 43.1 bits (100), Expect = 3e-04
Identities = 27/87 (31%), Positives = 46/87 (52%), Gaps = 9/87 (10%)
Query: 218 QNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEG 277
++L+ G GAG +S+T T PLD K +QV HA + G++ Q++++ G
Sbjct: 208 RHLVAGGGAGAVSRTCTAPLDRLKVLMQV----HASRS-----NNMGIVGGFTQMIREGG 258
Query: 278 ALGFFKGLSPSLLKAALSTGFMFFSYE 304
A ++G ++LK A + F +YE
Sbjct: 259 ARSLWRGNGINVLKIAPESAIKFMAYE 285
>gi|56699401 solute carrier family 25, member 25 isoform a [Homo
sapiens]
Length = 469
Score = 115 bits (287), Expect = 7e-26
Identities = 75/285 (26%), Positives = 134/285 (47%), Gaps = 17/285 (5%)
Query: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
VAG +G V+R +P D +K+ Q+ R + GI+ Q+++E G + W
Sbjct: 191 VAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNM-------GIVGGFTQMIREGGARSLW 243
Query: 80 KGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPV 139
+G+ + A++F+++E + LV GS + V G LA +A +++P+
Sbjct: 244 RGNGINVLKIAPESAIKFMAYEQIKRLV--GSDQETLRIHERLVAGSLAGAIAQSSIYPM 301
Query: 140 DVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSL 199
+VL+TR A + + Y+ + + EG FYKG P ++ I PYAG+ + Y +L
Sbjct: 302 EVLKTRMALRKTGQ-YSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETL 360
Query: 200 KHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQV 259
K+ + L CG+ + + +YPL L + R+Q A+A+
Sbjct: 361 KNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQ------AQASIEGA 414
Query: 260 RRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
+ K +L+ EGA G ++GL+P+ +K + + YE
Sbjct: 415 PEVT-MSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYE 458
Score = 85.9 bits (211), Expect = 4e-17
Identities = 57/187 (30%), Positives = 92/187 (49%), Gaps = 16/187 (8%)
Query: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
VAGS++G + ++ I P +V+K R L+ + +Y G+L +R+IL EG AF+
Sbjct: 285 VAGSLAGAIAQSSIYPMEVLKTRMALRK--------TGQYSGMLDCARRILAREGVAAFY 336
Query: 80 KGHVPAQILSIGYGAVQFLSFEMLTE--LVHRGSVYDAREFSVHFVCGGLAACMATLTVH 137
KG+VP + I Y + +E L L H V CG +++ L +
Sbjct: 337 KGYVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASY 396
Query: 138 PVDVLRTRFAAQ----GEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQF 193
P+ ++RTR AQ G P+V T+ + R+EG Y+GLAP + + P + +
Sbjct: 397 PLALVRTRMQAQASIEGAPEV--TMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISY 454
Query: 194 SCYSSLK 200
Y +LK
Sbjct: 455 VVYENLK 461
Score = 73.6 bits (179), Expect = 2e-13
Identities = 49/193 (25%), Positives = 84/193 (43%), Gaps = 20/193 (10%)
Query: 121 HFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAP 180
H V GG A ++ P+D L+ + M R G + ++G
Sbjct: 189 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGI 248
Query: 181 TLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENL---QNLLCGSGAGVISKTLTYPL 237
++ I P + ++F Y +K L G E L + L+ GS AG I+++ YP+
Sbjct: 249 NVLKIAPESAIKFMAYEQIKRLV-------GSDQETLRIHERLVAGSLAGAIAQSSIYPM 301
Query: 238 DLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTG 297
++ K R+ A + +Y G++DCA+++L +EG F+KG P++L G
Sbjct: 302 EVLKTRM----------ALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAG 351
Query: 298 FMFFSYEFFCNVF 310
YE N +
Sbjct: 352 IDLAVYETLKNAW 364
Score = 43.1 bits (100), Expect = 3e-04
Identities = 27/87 (31%), Positives = 46/87 (52%), Gaps = 9/87 (10%)
Query: 218 QNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEG 277
++L+ G GAG +S+T T PLD K +QV HA + G++ Q++++ G
Sbjct: 188 RHLVAGGGAGAVSRTCTAPLDRLKVLMQV----HASRS-----NNMGIVGGFTQMIREGG 238
Query: 278 ALGFFKGLSPSLLKAALSTGFMFFSYE 304
A ++G ++LK A + F +YE
Sbjct: 239 ARSLWRGNGINVLKIAPESAIKFMAYE 265
>gi|56699405 solute carrier family 25, member 25 isoform d [Homo
sapiens]
Length = 366
Score = 115 bits (287), Expect = 7e-26
Identities = 75/285 (26%), Positives = 134/285 (47%), Gaps = 17/285 (5%)
Query: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
VAG +G V+R +P D +K+ Q+ R + GI+ Q+++E G + W
Sbjct: 88 VAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNM-------GIVGGFTQMIREGGARSLW 140
Query: 80 KGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPV 139
+G+ + A++F+++E + LV GS + V G LA +A +++P+
Sbjct: 141 RGNGINVLKIAPESAIKFMAYEQIKRLV--GSDQETLRIHERLVAGSLAGAIAQSSIYPM 198
Query: 140 DVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSL 199
+VL+TR A + + Y+ + + EG FYKG P ++ I PYAG+ + Y +L
Sbjct: 199 EVLKTRMALRKTGQ-YSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETL 257
Query: 200 KHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQV 259
K+ + L CG+ + + +YPL L + R+Q A+A+
Sbjct: 258 KNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQ------AQASIEGA 311
Query: 260 RRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
+ K +L+ EGA G ++GL+P+ +K + + YE
Sbjct: 312 PEVT-MSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYE 355
Score = 85.9 bits (211), Expect = 4e-17
Identities = 57/187 (30%), Positives = 92/187 (49%), Gaps = 16/187 (8%)
Query: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
VAGS++G + ++ I P +V+K R L+ + +Y G+L +R+IL EG AF+
Sbjct: 182 VAGSLAGAIAQSSIYPMEVLKTRMALRK--------TGQYSGMLDCARRILAREGVAAFY 233
Query: 80 KGHVPAQILSIGYGAVQFLSFEMLTE--LVHRGSVYDAREFSVHFVCGGLAACMATLTVH 137
KG+VP + I Y + +E L L H V CG +++ L +
Sbjct: 234 KGYVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASY 293
Query: 138 PVDVLRTRFAAQ----GEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQF 193
P+ ++RTR AQ G P+V T+ + R+EG Y+GLAP + + P + +
Sbjct: 294 PLALVRTRMQAQASIEGAPEV--TMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISY 351
Query: 194 SCYSSLK 200
Y +LK
Sbjct: 352 VVYENLK 358
Score = 73.6 bits (179), Expect = 2e-13
Identities = 49/193 (25%), Positives = 84/193 (43%), Gaps = 20/193 (10%)
Query: 121 HFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAP 180
H V GG A ++ P+D L+ + M R G + ++G
Sbjct: 86 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGI 145
Query: 181 TLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENL---QNLLCGSGAGVISKTLTYPL 237
++ I P + ++F Y +K L G E L + L+ GS AG I+++ YP+
Sbjct: 146 NVLKIAPESAIKFMAYEQIKRLV-------GSDQETLRIHERLVAGSLAGAIAQSSIYPM 198
Query: 238 DLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTG 297
++ K R+ A + +Y G++DCA+++L +EG F+KG P++L G
Sbjct: 199 EVLKTRM----------ALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAG 248
Query: 298 FMFFSYEFFCNVF 310
YE N +
Sbjct: 249 IDLAVYETLKNAW 261
Score = 43.1 bits (100), Expect = 3e-04
Identities = 27/87 (31%), Positives = 46/87 (52%), Gaps = 9/87 (10%)
Query: 218 QNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEG 277
++L+ G GAG +S+T T PLD K +QV HA + G++ Q++++ G
Sbjct: 85 RHLVAGGGAGAVSRTCTAPLDRLKVLMQV----HASRS-----NNMGIVGGFTQMIREGG 135
Query: 278 ALGFFKGLSPSLLKAALSTGFMFFSYE 304
A ++G ++LK A + F +YE
Sbjct: 136 ARSLWRGNGINVLKIAPESAIKFMAYE 162
>gi|56699403 solute carrier family 25, member 25 isoform b [Homo
sapiens]
Length = 503
Score = 115 bits (287), Expect = 7e-26
Identities = 75/285 (26%), Positives = 134/285 (47%), Gaps = 17/285 (5%)
Query: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
VAG +G V+R +P D +K+ Q+ R + GI+ Q+++E G + W
Sbjct: 225 VAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNM-------GIVGGFTQMIREGGARSLW 277
Query: 80 KGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPV 139
+G+ + A++F+++E + LV GS + V G LA +A +++P+
Sbjct: 278 RGNGINVLKIAPESAIKFMAYEQIKRLV--GSDQETLRIHERLVAGSLAGAIAQSSIYPM 335
Query: 140 DVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSL 199
+VL+TR A + + Y+ + + EG FYKG P ++ I PYAG+ + Y +L
Sbjct: 336 EVLKTRMALRKTGQ-YSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETL 394
Query: 200 KHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQV 259
K+ + L CG+ + + +YPL L + R+Q A+A+
Sbjct: 395 KNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQ------AQASIEGA 448
Query: 260 RRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
+ K +L+ EGA G ++GL+P+ +K + + YE
Sbjct: 449 PEVT-MSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYE 492
Score = 85.9 bits (211), Expect = 4e-17
Identities = 57/187 (30%), Positives = 92/187 (49%), Gaps = 16/187 (8%)
Query: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
VAGS++G + ++ I P +V+K R L+ + +Y G+L +R+IL EG AF+
Sbjct: 319 VAGSLAGAIAQSSIYPMEVLKTRMALRK--------TGQYSGMLDCARRILAREGVAAFY 370
Query: 80 KGHVPAQILSIGYGAVQFLSFEMLTE--LVHRGSVYDAREFSVHFVCGGLAACMATLTVH 137
KG+VP + I Y + +E L L H V CG +++ L +
Sbjct: 371 KGYVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASY 430
Query: 138 PVDVLRTRFAAQ----GEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQF 193
P+ ++RTR AQ G P+V T+ + R+EG Y+GLAP + + P + +
Sbjct: 431 PLALVRTRMQAQASIEGAPEV--TMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISY 488
Query: 194 SCYSSLK 200
Y +LK
Sbjct: 489 VVYENLK 495
Score = 73.6 bits (179), Expect = 2e-13
Identities = 49/193 (25%), Positives = 84/193 (43%), Gaps = 20/193 (10%)
Query: 121 HFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAP 180
H V GG A ++ P+D L+ + M R G + ++G
Sbjct: 223 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGI 282
Query: 181 TLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENL---QNLLCGSGAGVISKTLTYPL 237
++ I P + ++F Y +K L G E L + L+ GS AG I+++ YP+
Sbjct: 283 NVLKIAPESAIKFMAYEQIKRLV-------GSDQETLRIHERLVAGSLAGAIAQSSIYPM 335
Query: 238 DLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTG 297
++ K R+ A + +Y G++DCA+++L +EG F+KG P++L G
Sbjct: 336 EVLKTRM----------ALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAG 385
Query: 298 FMFFSYEFFCNVF 310
YE N +
Sbjct: 386 IDLAVYETLKNAW 398
Score = 43.1 bits (100), Expect = 3e-04
Identities = 27/87 (31%), Positives = 46/87 (52%), Gaps = 9/87 (10%)
Query: 218 QNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEG 277
++L+ G GAG +S+T T PLD K +QV HA + G++ Q++++ G
Sbjct: 222 RHLVAGGGAGAVSRTCTAPLDRLKVLMQV----HASRS-----NNMGIVGGFTQMIREGG 272
Query: 278 ALGFFKGLSPSLLKAALSTGFMFFSYE 304
A ++G ++LK A + F +YE
Sbjct: 273 ARSLWRGNGINVLKIAPESAIKFMAYE 299
>gi|48476342 solute carrier family 25, member 23 [Homo sapiens]
Length = 468
Score = 110 bits (274), Expect = 2e-24
Identities = 73/285 (25%), Positives = 133/285 (46%), Gaps = 17/285 (5%)
Query: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
VAG+V+G V+R +P D +K+ Q+ + +R + IL R ++ E G + W
Sbjct: 190 VAGAVAGAVSRTGTAPLDRLKVFMQVHASKTNRLN-------ILGGLRSMVLEGGIRSLW 242
Query: 80 KGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPV 139
+G+ + A++F+++E + + + FV G LA A ++P+
Sbjct: 243 RGNGINVLKIAPESAIKFMAYEQIKRAIL--GQQETLHVQERFVAGSLAGATAQTIIYPM 300
Query: 140 DVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSL 199
+VL+TR + + Y L + EGP+ FY+G P ++ I PYAG+ + Y +L
Sbjct: 301 EVLKTRLTLRRTGQ-YKGLLDCARRILEREGPRAFYRGYLPNVLGIIPYAGIDLAVYETL 359
Query: 200 KHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQV 259
K+ + + L L CG+ + + +YPL L + R+Q A G
Sbjct: 360 KNWWLQQYSHDSADPGILVLLACGTISSTCGQIASYPLALVRTRMQA----QASIEGGPQ 415
Query: 260 RRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
GL+ + +L +EG G ++G++P+ +K + + YE
Sbjct: 416 LSMLGLL---RHILSQEGMRGLYRGIAPNFMKVIPAVSISYVVYE 457
Score = 85.1 bits (209), Expect = 7e-17
Identities = 52/189 (27%), Positives = 96/189 (50%), Gaps = 20/189 (10%)
Query: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
VAGS++G + +I P +V+K R L+ + +Y G+L +R+IL+ EGP AF+
Sbjct: 284 VAGSLAGATAQTIIYPMEVLKTRLTLRR--------TGQYKGLLDCARRILEREGPRAFY 335
Query: 80 KGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDARE--FSVHFVCGGLAACMATLTVH 137
+G++P + I Y + +E L + +D+ + V CG +++ + +
Sbjct: 336 RGYLPNVLGIIPYAGIDLAVYETLKNWWLQQYSHDSADPGILVLLACGTISSTCGQIASY 395
Query: 138 PVDVLRTRFAAQ----GEPKV--YNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGL 191
P+ ++RTR AQ G P++ LRH + EG + Y+G+AP + + P +
Sbjct: 396 PLALVRTRMQAQASIEGGPQLSMLGLLRHILS----QEGMRGLYRGIAPNFMKVIPAVSI 451
Query: 192 QFSCYSSLK 200
+ Y ++K
Sbjct: 452 SYVVYENMK 460
Score = 67.0 bits (162), Expect = 2e-11
Identities = 44/186 (23%), Positives = 84/186 (45%), Gaps = 14/186 (7%)
Query: 123 VCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTL 182
V G +A ++ P+D L+ + + +M G + ++G +
Sbjct: 190 VAGAVAGAVSRTGTAPLDRLKVFMQVHASKTNRLNILGGLRSMVLEGGIRSLWRGNGINV 249
Query: 183 IAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKK 242
+ I P + ++F Y +K AI + + + + GS AG ++T+ YP+++ K
Sbjct: 250 LKIAPESAIKFMAYEQIKR----AILGQQETLHVQERFVAGSLAGATAQTIIYPMEVLKT 305
Query: 243 RLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFS 302
RL + + +YKGL+DCA+++L++EG F++G P++L G
Sbjct: 306 RLTLR----------RTGQYKGLLDCARRILEREGPRAFYRGYLPNVLGIIPYAGIDLAV 355
Query: 303 YEFFCN 308
YE N
Sbjct: 356 YETLKN 361
Score = 35.4 bits (80), Expect = 0.068
Identities = 27/103 (26%), Positives = 47/103 (45%), Gaps = 14/103 (13%)
Query: 207 IPAEGKKNENL-----QNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRR 261
+P E K E L + L+ G+ AG +S+T T PLD K +QV + R
Sbjct: 171 VPDEFSKQEKLTGMWWKQLVAGAVAGAVSRTGTAPLDRLKVFMQVHASKTNRL------- 223
Query: 262 YKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
++ + ++ + G ++G ++LK A + F +YE
Sbjct: 224 --NILGGLRSMVLEGGIRSLWRGNGINVLKIAPESAIKFMAYE 264
>gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo
sapiens]
Length = 477
Score = 109 bits (273), Expect = 3e-24
Identities = 79/287 (27%), Positives = 136/287 (47%), Gaps = 21/287 (7%)
Query: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
+AG ++G V+R +P D +KI Q+ S+SD + G RQ+++E G + W
Sbjct: 199 LAGGIAGAVSRTSTAPLDRLKIMMQVHG---SKSDKMNIFGGF----RQMVKEGGIRSLW 251
Query: 80 KGHVPAQILSIGYGAVQFLSFEMLTELV-HRGSVYDAREFSVHFVCGGLAACMATLTVHP 138
+G+ I AV+F ++E +L+ G E F+ G +A A ++P
Sbjct: 252 RGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFE---RFISGSMAGATAQTFIYP 308
Query: 139 VDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSS 198
++V++TR A G+ Y+ + + + EG FYKG P L+ I PYAG+ + Y
Sbjct: 309 MEVMKTRLAV-GKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYEL 367
Query: 199 LKHLYKWAIPAEGKKNENLQNLL-CGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFG 257
LK Y A+ N + LL CG+ + + +YPL L + R+Q
Sbjct: 368 LKS-YWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLN 426
Query: 258 QVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
V + ++++ KEG G ++G++P+ +K + G + YE
Sbjct: 427 MVGLF-------RRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYE 466
Score = 77.0 bits (188), Expect = 2e-14
Identities = 53/201 (26%), Positives = 95/201 (47%), Gaps = 22/201 (10%)
Query: 9 DGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQ 68
+G+ F+ ++GS++G + I P +V+K R + + +Y GI +++
Sbjct: 282 EGQKIGTFERFISGSMAGATAQTFIYPMEVMKTRLAV--------GKTGQYSGIYDCAKK 333
Query: 69 ILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFV--CGG 126
IL+ EG AF+KG+VP + I Y + +E+L D+ V + CG
Sbjct: 334 ILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGA 393
Query: 127 LAACMATLTVHPVDVLRTRFAAQ----GEPKVYNTLRHAVGTMYR---SEGPQVFYKGLA 179
L++ L +P+ ++RTR AQ G P++ + VG R EG Y+G+
Sbjct: 394 LSSTCGQLASYPLALVRTRMQAQAMLEGSPQL-----NMVGLFRRIISKEGIPGLYRGIT 448
Query: 180 PTLIAIFPYAGLQFSCYSSLK 200
P + + P G+ + Y ++K
Sbjct: 449 PNFMKVLPAVGISYVVYENMK 469
Score = 41.2 bits (95), Expect = 0.001
Identities = 29/96 (30%), Positives = 47/96 (48%), Gaps = 11/96 (11%)
Query: 210 EGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARA-AFGQVRRYKGLMDC 268
E K + + LL G AG +S+T T PLD K +QV G + + FG R
Sbjct: 188 EKKSGQWWRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFR-------- 239
Query: 269 AKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
Q++++ G ++G +++K A T F++YE
Sbjct: 240 --QMVKEGGIRSLWRGNGTNVIKIAPETAVKFWAYE 273
>gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo
sapiens]
Length = 458
Score = 109 bits (273), Expect = 3e-24
Identities = 79/287 (27%), Positives = 136/287 (47%), Gaps = 21/287 (7%)
Query: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
+AG ++G V+R +P D +KI Q+ S+SD + G RQ+++E G + W
Sbjct: 180 LAGGIAGAVSRTSTAPLDRLKIMMQVHG---SKSDKMNIFGGF----RQMVKEGGIRSLW 232
Query: 80 KGHVPAQILSIGYGAVQFLSFEMLTELV-HRGSVYDAREFSVHFVCGGLAACMATLTVHP 138
+G+ I AV+F ++E +L+ G E F+ G +A A ++P
Sbjct: 233 RGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFE---RFISGSMAGATAQTFIYP 289
Query: 139 VDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSS 198
++V++TR A G+ Y+ + + + EG FYKG P L+ I PYAG+ + Y
Sbjct: 290 MEVMKTRLAV-GKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYEL 348
Query: 199 LKHLYKWAIPAEGKKNENLQNLL-CGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFG 257
LK Y A+ N + LL CG+ + + +YPL L + R+Q
Sbjct: 349 LKS-YWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLN 407
Query: 258 QVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
V + ++++ KEG G ++G++P+ +K + G + YE
Sbjct: 408 MVGLF-------RRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYE 447
Score = 77.0 bits (188), Expect = 2e-14
Identities = 53/201 (26%), Positives = 95/201 (47%), Gaps = 22/201 (10%)
Query: 9 DGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQ 68
+G+ F+ ++GS++G + I P +V+K R + + +Y GI +++
Sbjct: 263 EGQKIGTFERFISGSMAGATAQTFIYPMEVMKTRLAV--------GKTGQYSGIYDCAKK 314
Query: 69 ILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFV--CGG 126
IL+ EG AF+KG+VP + I Y + +E+L D+ V + CG
Sbjct: 315 ILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGA 374
Query: 127 LAACMATLTVHPVDVLRTRFAAQ----GEPKVYNTLRHAVGTMYR---SEGPQVFYKGLA 179
L++ L +P+ ++RTR AQ G P++ + VG R EG Y+G+
Sbjct: 375 LSSTCGQLASYPLALVRTRMQAQAMLEGSPQL-----NMVGLFRRIISKEGIPGLYRGIT 429
Query: 180 PTLIAIFPYAGLQFSCYSSLK 200
P + + P G+ + Y ++K
Sbjct: 430 PNFMKVLPAVGISYVVYENMK 450
Score = 41.2 bits (95), Expect = 0.001
Identities = 29/96 (30%), Positives = 47/96 (48%), Gaps = 11/96 (11%)
Query: 210 EGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARA-AFGQVRRYKGLMDC 268
E K + + LL G AG +S+T T PLD K +QV G + + FG R
Sbjct: 169 EKKSGQWWRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFR-------- 220
Query: 269 AKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
Q++++ G ++G +++K A T F++YE
Sbjct: 221 --QMVKEGGIRSLWRGNGTNVIKIAPETAVKFWAYE 254
>gi|21687151 mitochondrial solute carrier protein [Homo sapiens]
Length = 341
Score = 105 bits (261), Expect = 7e-23
Identities = 79/300 (26%), Positives = 147/300 (49%), Gaps = 20/300 (6%)
Query: 9 DGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQ 68
DGR ++ AG ++G ++ +L +P ++ + Q+ R P A H + +A
Sbjct: 7 DGRLTGGQRLLCAG-LAGTLSLSLTAPLELATVLAQVGVVRGHARGPWATGHRVWRA--- 62
Query: 69 ILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLA 128
EG A WKG+ A + AVQ ++ L + ++ S+ + G LA
Sbjct: 63 ----EGLRALWKGNAVACLRLFPCSAVQLAAYRKFVVLFTDDLGHISQWSSI--MAGSLA 116
Query: 129 ACMATLTVHPVDVLRTRFAAQG--EPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIF 186
++T+ +P D+++TR Q EP Y L HA T+Y+ EG Y+G++ T++
Sbjct: 117 GMVSTIVTYPTDLIKTRLIMQNILEPS-YRGLLHAFSTIYQQEGFLALYRGVSLTVVGAL 175
Query: 187 PYAGLQFSCYSSLKHLYKWAIPAEG-KKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQ 245
P++ Y +L+ + W P + +N N+ A +++TL++P + K+++Q
Sbjct: 176 PFSAGSLLVYMNLEKI--WNGPRDQFSLPQNFANVCL---AAAVTQTLSFPFETVKRKMQ 230
Query: 246 VGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYEF 305
+ + G + G +DC +Q+++ +G LG + GL+ +LLK G MF ++EF
Sbjct: 231 AQS-PYLPHSGGVDVHFSGAVDCFRQIVKAQGVLGLWNGLTANLLKIVPYFGIMFSTFEF 289
>gi|116235462 solute carrier family 25, member 45 isoform a [Homo
sapiens]
Length = 288
Score = 98.6 bits (244), Expect = 7e-21
Identities = 79/299 (26%), Positives = 128/299 (42%), Gaps = 36/299 (12%)
Query: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
VAG +SG + L PFD +K+R Q Q Y GI+ +I + E F+
Sbjct: 7 VAGWISGALGLVLGHPFDTVKVRLQTQ----------TTYRGIVDCMVKIYRHESLLGFF 56
Query: 80 KG-HVP----AQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATL 134
KG P A + S+ +G V + +LT H+ + F+ G +
Sbjct: 57 KGMSFPIASIAVVNSVLFG-VYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAY 115
Query: 135 TVHPVDVLRTRFAAQGEPKV--------YNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIF 186
+ P D+++ R Q EP+ Y H +++R EGP+ ++G +
Sbjct: 116 CLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDT 175
Query: 187 PYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQV 246
P G+ F Y L Y EG+ + L+ G AG+ S PLD+ K R+Q+
Sbjct: 176 PTVGIYFITYEGLCRQYT----PEGQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQM 231
Query: 247 GGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYEF 305
G R Y+G++DC +++EG FF+G++ + +A F SYE+
Sbjct: 232 DGLRR--------RVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEY 282
Score = 70.1 bits (170), Expect = 2e-12
Identities = 47/191 (24%), Positives = 87/191 (45%), Gaps = 9/191 (4%)
Query: 18 VAVAGSVSGLVTRALISPFDVIKIRFQLQHE-RLSRSDPSAKYHGILQASRQILQEEGPT 76
+ +AG G + ++PFD+IK+R Q Q E R P +Y G + + I +EEGP
Sbjct: 102 IFLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPR 161
Query: 77 AFWKGHVPAQILSIGYGAVQFLSFE-MLTELVHRGSVYDAREFSVHFVCGGLAACMATLT 135
++G + + F+++E + + G + + V GG A + +
Sbjct: 162 GLFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSS---ATVLVAGGFAGIASWVA 218
Query: 136 VHPVDVLRTRFAAQG-EPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFS 194
P+D++++R G +VY + + + R EG VF++G+ FP + F
Sbjct: 219 ATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFL 278
Query: 195 CYSSLKHLYKW 205
Y ++L +W
Sbjct: 279 SY---EYLLRW 286
Score = 62.4 bits (150), Expect = 5e-10
Identities = 47/191 (24%), Positives = 78/191 (40%), Gaps = 6/191 (3%)
Query: 122 FVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPT 181
FV G ++ + + HP D ++ R Q Y + + +YR E F+KG++
Sbjct: 6 FVAGWISGALGLVLGHPFDTVKVRLQTQ---TTYRGIVDCMVKIYRHESLLGFFKGMSFP 62
Query: 182 LIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKN--ENLQNLLCGSGAGVISKTLTYPLDL 239
+ +I + F YS+ + E + + L G G + P DL
Sbjct: 63 IASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYCLAPFDL 122
Query: 240 FKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFM 299
K RLQ A+ RY+G + CA + ++EG G F+G L+ + G
Sbjct: 123 IKVRLQNQTEPRAQPG-SPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTPTVGIY 181
Query: 300 FFSYEFFCNVF 310
F +YE C +
Sbjct: 182 FITYEGLCRQY 192
Score = 46.6 bits (109), Expect = 3e-05
Identities = 29/96 (30%), Positives = 46/96 (47%), Gaps = 6/96 (6%)
Query: 8 PDGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASR 67
P+G+N + V VAG +G+ + +P D+IK R Q+ R Y G+L
Sbjct: 194 PEGQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLR------RRVYQGMLDCMV 247
Query: 68 QILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEML 103
+++EG F++G + AV FLS+E L
Sbjct: 248 SSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYL 283
Score = 42.4 bits (98), Expect = 6e-04
Identities = 24/87 (27%), Positives = 40/87 (45%), Gaps = 12/87 (13%)
Query: 217 LQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKE 276
++ + G +G + L +P D K RLQ Y+G++DC ++ + E
Sbjct: 3 VEEFVAGWISGALGLVLGHPFDTVKVRLQT------------QTTYRGIVDCMVKIYRHE 50
Query: 277 GALGFFKGLSPSLLKAALSTGFMFFSY 303
LGFFKG+S + A+ +F Y
Sbjct: 51 SLLGFFKGMSFPIASIAVVNSVLFGVY 77
>gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Homo
sapiens]
Length = 325
Score = 96.3 bits (238), Expect = 3e-20
Identities = 71/287 (24%), Positives = 128/287 (44%), Gaps = 15/287 (5%)
Query: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
V G ++ +V P D+ K R Q+Q + + KY G+ A +I +EEG A +
Sbjct: 45 VYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALY 104
Query: 80 KGHVPAQILSIGYGAVQFLSFEMLTEL-VHRGSVYDAREFSVHFVCGGLAACMATLTVHP 138
G PA + YG ++ ++ L L V R + ++ +CG ++ +++ +P
Sbjct: 105 SGIAPALLRQASYGTIKIGIYQSLKRLFVER---LEDETLLINMICGVVSGVISSTIANP 161
Query: 139 VDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYS- 197
DVL+ R AQG ++ + +Y+ EG + ++G+ PT G++ Y
Sbjct: 162 TDVLKIRMQAQGS-LFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVYDI 220
Query: 198 SLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFG 257
+ KHL + + + + CG + S P+D+ + R+ + RA G
Sbjct: 221 TKKHLILSGMMGDTILTHFVSSFTCGLAGALASN----PVDVVRTRMM-----NQRAIVG 271
Query: 258 QVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
V YKG +D ++ + EG +KG P+ L+ F +YE
Sbjct: 272 HVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYE 318
Score = 84.3 bits (207), Expect = 1e-16
Identities = 57/184 (30%), Positives = 88/184 (47%), Gaps = 23/184 (12%)
Query: 122 FVCGGLAACMATLTVHPVDVLRTRFAAQGE-------PKVYNTLRHAVGTMYRSEGPQVF 174
FV GGLA+ +A PVD+ +TR QG+ Y + HA+ + + EG
Sbjct: 44 FVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLAL 103
Query: 175 YKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQ-NLLCGSGAGVISKTL 233
Y G+AP L+ Y ++ Y SLK L+ E ++E L N++CG +GVIS T+
Sbjct: 104 YSGIAPALLRQASYGTIKIGIYQSLKRLF-----VERLEDETLLINMICGVVSGVISSTI 158
Query: 234 TYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAA 293
P D+ K R+Q G + G + Q+EG G ++G+ P+ +AA
Sbjct: 159 ANPTDVLKIRMQAQGSLFQGSMIGSF----------IDIYQQEGTRGLWRGVVPTAQRAA 208
Query: 294 LSTG 297
+ G
Sbjct: 209 IVVG 212
Score = 48.1 bits (113), Expect = 1e-05
Identities = 25/78 (32%), Positives = 48/78 (61%), Gaps = 2/78 (2%)
Query: 216 NLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQK 275
N + + G A ++++ T+P+DL K RLQV G + A F ++ +Y+G+ ++ ++
Sbjct: 40 NWKPFVYGGLASIVAEFGTFPVDLTKTRLQVQG-QSIDARFKEI-KYRGMFHALFRICKE 97
Query: 276 EGALGFFKGLSPSLLKAA 293
EG L + G++P+LL+ A
Sbjct: 98 EGVLALYSGIAPALLRQA 115
Score = 29.6 bits (65), Expect = 3.7
Identities = 21/87 (24%), Positives = 37/87 (42%), Gaps = 3/87 (3%)
Query: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
V+ GL +P DV++ R Q + D Y G + ++ + EG A +
Sbjct: 240 VSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVD---LYKGTVDGILKMWKHEGFFALY 296
Query: 80 KGHVPAQILSIGYGAVQFLSFEMLTEL 106
KG P + + + F+++E L L
Sbjct: 297 KGFWPNWLRLGPWNIIFFITYEQLKRL 323
>gi|13259543 solute carrier family 25, member 14 isoform UCP5S [Homo
sapiens]
Length = 322
Score = 96.3 bits (238), Expect = 3e-20
Identities = 71/287 (24%), Positives = 128/287 (44%), Gaps = 15/287 (5%)
Query: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
V G ++ +V P D+ K R Q+Q + + KY G+ A +I +EEG A +
Sbjct: 42 VYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALY 101
Query: 80 KGHVPAQILSIGYGAVQFLSFEMLTEL-VHRGSVYDAREFSVHFVCGGLAACMATLTVHP 138
G PA + YG ++ ++ L L V R + ++ +CG ++ +++ +P
Sbjct: 102 SGIAPALLRQASYGTIKIGIYQSLKRLFVER---LEDETLLINMICGVVSGVISSTIANP 158
Query: 139 VDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYS- 197
DVL+ R AQG ++ + +Y+ EG + ++G+ PT G++ Y
Sbjct: 159 TDVLKIRMQAQGS-LFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVYDI 217
Query: 198 SLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFG 257
+ KHL + + + + CG + S P+D+ + R+ + RA G
Sbjct: 218 TKKHLILSGMMGDTILTHFVSSFTCGLAGALASN----PVDVVRTRMM-----NQRAIVG 268
Query: 258 QVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
V YKG +D ++ + EG +KG P+ L+ F +YE
Sbjct: 269 HVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYE 315
Score = 84.7 bits (208), Expect = 1e-16
Identities = 61/204 (29%), Positives = 96/204 (47%), Gaps = 27/204 (13%)
Query: 106 LVHRGSVYDAREFS----VHFVCGGLAACMATLTVHPVDVLRTRFAAQGE-------PKV 154
++H+ S + E S FV GGLA+ +A PVD+ +TR QG+
Sbjct: 21 VIHQKSTTVSHEMSGLNWKPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIK 80
Query: 155 YNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKN 214
Y + HA+ + + EG Y G+AP L+ Y ++ Y SLK L+ E ++
Sbjct: 81 YRGMFHALFRICKEEGVLALYSGIAPALLRQASYGTIKIGIYQSLKRLF-----VERLED 135
Query: 215 ENLQ-NLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVL 273
E L N++CG +GVIS T+ P D+ K R+Q G + G +
Sbjct: 136 ETLLINMICGVVSGVISSTIANPTDVLKIRMQAQGSLFQGSMIGSF----------IDIY 185
Query: 274 QKEGALGFFKGLSPSLLKAALSTG 297
Q+EG G ++G+ P+ +AA+ G
Sbjct: 186 QQEGTRGLWRGVVPTAQRAAIVVG 209
Score = 29.6 bits (65), Expect = 3.7
Identities = 21/87 (24%), Positives = 37/87 (42%), Gaps = 3/87 (3%)
Query: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
V+ GL +P DV++ R Q + D Y G + ++ + EG A +
Sbjct: 237 VSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVD---LYKGTVDGILKMWKHEGFFALY 293
Query: 80 KGHVPAQILSIGYGAVQFLSFEMLTEL 106
KG P + + + F+++E L L
Sbjct: 294 KGFWPNWLRLGPWNIIFFITYEQLKRL 320
>gi|13775208 solute carrier family 25 (mitochondrial carrier;
adenine nucleotide translocator), member 31 [Homo
sapiens]
Length = 315
Score = 94.0 bits (232), Expect = 2e-19
Identities = 70/279 (25%), Positives = 124/279 (44%), Gaps = 20/279 (7%)
Query: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
+AG V+ V++ ++P + +K+ Q+Q S P A+Y G++ +I +E+G +FW
Sbjct: 25 LAGGVAAAVSKTAVAPIERVKLLLQVQASSKQIS-PEARYKGMVDCLVRIPREQGFFSFW 83
Query: 80 KGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDA---REFSVHFVCGGLAACMATLTV 136
+G++ I A+ F + +L G + R F + GG A + V
Sbjct: 84 RGNLANVIRYFPTQALNFAFKDKYKQLFMSGVNKEKQFWRWFLANLASGGAAGATSLCVV 143
Query: 137 HPVDVLRTRFAAQ----GEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQ 192
+P+D RTR E + + L + + +S+G Y+G ++ I Y
Sbjct: 144 YPLDFARTRLGVDIGKGPEERQFKGLGDCIMKIAKSDGIAGLYQGFGVSVQGIIVYRASY 203
Query: 193 FSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHA 252
F Y ++K L + KK L + S L+YP D ++R+ + E
Sbjct: 204 FGAYDTVKGLLP-----KPKKTPFLVSFFIAQVVTTCSGILSYPFDTVRRRMMMQSGEAK 258
Query: 253 RAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLK 291
R +YKG +DC ++ Q EG FF+G ++L+
Sbjct: 259 R-------QYKGTLDCFVKIYQHEGISSFFRGAFSNVLR 290
Score = 67.8 bits (164), Expect = 1e-11
Identities = 50/200 (25%), Positives = 88/200 (44%), Gaps = 12/200 (6%)
Query: 112 VYDAREFSVHFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKV------YNTLRHAVGTM 165
++DA F + GG+AA ++ V P++ ++ Q K Y + + +
Sbjct: 14 LFDASSFGKDLLAGGVAAAVSKTAVAPIERVKLLLQVQASSKQISPEARYKGMVDCLVRI 73
Query: 166 YRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKK-NENLQNLLCGS 224
R +G F++G +I FP L F+ K L+ + E + L NL G
Sbjct: 74 PREQGFFSFWRGNLANVIRYFPTQALNFAFKDKYKQLFMSGVNKEKQFWRWFLANLASGG 133
Query: 225 GAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKG 284
AG S + YPLD + RL G + + + R++KGL DC ++ + +G G ++G
Sbjct: 134 AAGATSLCVVYPLDFARTRL---GVDIGKGP--EERQFKGLGDCIMKIAKSDGIAGLYQG 188
Query: 285 LSPSLLKAALSTGFMFFSYE 304
S+ + F +Y+
Sbjct: 189 FGVSVQGIIVYRASYFGAYD 208
>gi|46094065 mitochondrial carrier family protein [Homo sapiens]
Length = 338
Score = 93.2 bits (230), Expect = 3e-19
Identities = 78/332 (23%), Positives = 137/332 (41%), Gaps = 41/332 (12%)
Query: 5 DPKPDGRNNTK---FQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRS-------- 53
DP+ G+ K Q +A ++T +++P DV+KIR Q Q+ L +
Sbjct: 2 DPETRGQEIIKVTPLQQMLASCTGAILTSVIVTPLDVVKIRLQAQNNPLPKGKCFVYSNG 61
Query: 54 -----------------DPSAKYHGILQASRQILQEEGPTAFWKGHVPAQILSIGYGAVQ 96
+ G L A +I++ EG + W G P ++++ +
Sbjct: 62 LMDHLCVCEEGGNKLWYKKPGNFQGTLDAFFKIIRNEGIKSLWSGLPPTLVMAVPATVIY 121
Query: 97 FLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYN 156
F ++ L+ L+ S E + V G +A A + P++++RT+ Q + Y
Sbjct: 122 FTCYDQLSALLR--SKLGENETCIPIVAGIVARFGAVTVISPLELIRTKM--QSKKFSYV 177
Query: 157 TLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNEN 216
L V +G ++G APT++ P++ + + Y LK KW G
Sbjct: 178 ELHRFVSKKVSEDGWISLWRGWAPTVLRDVPFSAMYWYNYEILK---KWLCEKSGLYEPT 234
Query: 217 LQ-NLLCGSGAGVISKTLTYPLDLFK--KRLQVGGFEHARAAFGQVRRYKGLMDCAKQVL 273
N G+ +G + T P D+ K K+ Q+ +E + + + + K ++
Sbjct: 235 FMINFTSGALSGSFAAVATLPFDVVKTQKQTQLWTYESHKIS---MPLHMSTWIIMKNIV 291
Query: 274 QKEGALGFFKGLSPSLLKAALSTGFMFFSYEF 305
K G G F GL P L+K A + M +YEF
Sbjct: 292 AKNGFSGLFSGLIPRLIKIAPACAIMISTYEF 323
Score = 54.7 bits (130), Expect = 1e-07
Identities = 47/204 (23%), Positives = 89/204 (43%), Gaps = 20/204 (9%)
Query: 10 GRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQI 69
G N T + VAG V+ +ISP ++I+ + Q S+ + H +
Sbjct: 137 GENETCIPI-VAGIVARFGAVTVISPLELIRTKMQ------SKKFSYVELHRFVSKK--- 186
Query: 70 LQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTE-LVHRGSVYDAREFSVHFVCGGLA 128
+ E+G + W+G P + + + A+ + ++E+L + L + +Y+ F ++F G L+
Sbjct: 187 VSEDGWISLWRGWAPTVLRDVPFSAMYWYNYEILKKWLCEKSGLYEP-TFMINFTSGALS 245
Query: 129 ACMATLTVHPVDVLRTRFAAQ----GEPKVYNTLRHAVGTMYRS----EGPQVFYKGLAP 180
A + P DV++T+ Q K+ L + + ++ G + GL P
Sbjct: 246 GSFAAVATLPFDVVKTQKQTQLWTYESHKISMPLHMSTWIIMKNIVAKNGFSGLFSGLIP 305
Query: 181 TLIAIFPYAGLQFSCYSSLKHLYK 204
LI I P + S Y K ++
Sbjct: 306 RLIKIAPACAIMISTYEFGKAFFQ 329
>gi|13259541 uncoupling protein 2 [Homo sapiens]
Length = 309
Score = 92.0 bits (227), Expect = 6e-19
Identities = 77/293 (26%), Positives = 127/293 (43%), Gaps = 32/293 (10%)
Query: 21 AGSVSGLVTRALISPFDVIKIRFQLQHERLS--RSDPSAKYHGILQASRQILQEEGPTAF 78
A ++ L+T P D K+R Q+Q E R+ SA+Y G++ +++ EGP +
Sbjct: 23 AACIADLIT----FPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRSL 78
Query: 79 WKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHP 138
+ G V + + +V+ ++ + + +GS + + + G +A P
Sbjct: 79 YNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHAS--IGSRLLAGSTTGALAVAVAQP 136
Query: 139 VDVLRTRFAAQ---GEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSC 195
DV++ RF AQ G + Y + +A T+ R EG + +KG +P + +
Sbjct: 137 TDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVT 196
Query: 196 YSSLKHLYKWAIPAEGKKNENLQNLLC----GSGAGVISKTLTYPLDLFKKRLQVGGFEH 251
Y +K A K N +L C GAG + + P+D+ K R +
Sbjct: 197 YDLIKD-------ALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTR-------Y 242
Query: 252 ARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
+A GQ Y CA +LQKEG F+KG PS L+ MF +YE
Sbjct: 243 MNSALGQ---YSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYE 292
Score = 87.4 bits (215), Expect = 2e-17
Identities = 52/183 (28%), Positives = 93/183 (50%), Gaps = 10/183 (5%)
Query: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
+AGS +G + A+ P DV+K+RFQ Q +R+ +Y + A + I +EEG W
Sbjct: 121 LAGSTTGALAVAVAQPTDVVKVRFQAQ----ARAGGGRRYQSTVNAYKTIAREEGFRGLW 176
Query: 80 KGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPV 139
KG P + + ++++++ + + + ++ + HF A T+ PV
Sbjct: 177 KGTSPNVARNAIVNCAELVTYDLIKDALLKANLM-TDDLPCHFTSAFGAGFCTTVIASPV 235
Query: 140 DVLRTRF--AAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYS 197
DV++TR+ +A G+ Y++ H TM + EGP+ FYKG P+ + + + + F Y
Sbjct: 236 DVVKTRYMNSALGQ---YSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYE 292
Query: 198 SLK 200
LK
Sbjct: 293 QLK 295
Score = 86.3 bits (212), Expect = 3e-17
Identities = 56/186 (30%), Positives = 91/186 (48%), Gaps = 21/186 (11%)
Query: 119 SVHFVCGGLAACMATLTVHPVDVLRTRFAAQGEPK---------VYNTLRHAVGTMYRSE 169
+V F+ G AAC+A L P+D + R QGE + Y + + TM R+E
Sbjct: 14 TVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTE 73
Query: 170 GPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENL-QNLLCGSGAGV 228
GP+ Y GL L +A ++ Y S+K Y +G ++ ++ LL GS G
Sbjct: 74 GPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFY-----TKGSEHASIGSRLLAGSTTGA 128
Query: 229 ISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPS 288
++ + P D+ K R Q A+A G RRY+ ++ K + ++EG G +KG SP+
Sbjct: 129 LAVAVAQPTDVVKVRFQ------AQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPN 182
Query: 289 LLKAAL 294
+ + A+
Sbjct: 183 VARNAI 188
>gi|149274643 solute carrier family 25, member 28 [Homo sapiens]
Length = 364
Score = 92.0 bits (227), Expect = 6e-19
Identities = 76/315 (24%), Positives = 139/315 (44%), Gaps = 40/315 (12%)
Query: 4 YDPKPDGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGIL 63
Y+ P G T VA G+V+G++ ++ P D +K R Q + DP+A+Y +L
Sbjct: 63 YEALPAGATVTTHMVA--GAVAGILEHCVMYPIDCVKTRMQ-----SLQPDPAARYRNVL 115
Query: 64 QASRQILQEEGPTAFWKGHVPAQILSIGYGAVQFLSF-------EMLTELVHRGSVYDAR 116
+A +I++ EG W+ + + G G L F + L++++H G
Sbjct: 116 EALWRIIRTEG---LWRPMRGLNVTATGAGPAHALYFACYEKLKKTLSDVIHPGG----- 167
Query: 117 EFSVHFVCGGLAACMATL----TVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQ 172
+ H + G A C+ATL ++P +V++ R P Y+ + V ++++EG
Sbjct: 168 --NSH-IANGAAGCVATLLHDAAMNPAEVVKQRMQMYNSP--YHRVTDCVRAVWQNEGAG 222
Query: 173 VFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKT 232
FY+ L P+ + F Y L+ + ++ ++L G+ AG ++
Sbjct: 223 AFYRSYTTQLTMNVPFQAIHFMTYEFLQEHFN-----PQRRYNPSSHVLSGACAGAVAAA 277
Query: 233 LTYPLDLFKKRLQVGGFEHARAAFGQVRRY-KGLMDCAKQVLQKEGALGFFKGLSPSLLK 291
T PLD+ K L + + A + + G+ + V Q G +F+G+ ++
Sbjct: 278 ATTPLDVCKTLLNT---QESLALNSHITGHITGMASAFRTVYQVGGVTAYFRGVQARVIY 334
Query: 292 AALSTGFMFFSYEFF 306
ST + YEFF
Sbjct: 335 QIPSTAIAWSVYEFF 349
Score = 67.4 bits (163), Expect = 2e-11
Identities = 48/198 (24%), Positives = 89/198 (44%), Gaps = 21/198 (10%)
Query: 13 NTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQE 72
N+ AG V+ L+ A ++P +V+K R Q+ + + YH + R + Q
Sbjct: 168 NSHIANGAAGCVATLLHDAAMNPAEVVKQRMQMYN---------SPYHRVTDCVRAVWQN 218
Query: 73 EGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMA 132
EG AF++ + +++ + A+ F+++E L E + Y+ S H + G A +A
Sbjct: 219 EGAGAFYRSYTTQLTMNVPFQAIHFMTYEFLQEHFNPQRRYNP---SSHVLSGACAGAVA 275
Query: 133 TLTVHPVDVLRTRFAAQGEPKVYNT--------LRHAVGTMYRSEGPQVFYKGLAPTLIA 184
P+DV +T Q E N+ + A T+Y+ G +++G+ +I
Sbjct: 276 AAATTPLDVCKTLLNTQ-ESLALNSHITGHITGMASAFRTVYQVGGVTAYFRGVQARVIY 334
Query: 185 IFPYAGLQFSCYSSLKHL 202
P + +S Y K+L
Sbjct: 335 QIPSTAIAWSVYEFFKYL 352
Score = 65.9 bits (159), Expect = 5e-11
Identities = 51/199 (25%), Positives = 83/199 (41%), Gaps = 15/199 (7%)
Query: 119 SVHFVCGGLAACMATLTVHPVDVLRTRFAA-QGEPKV-YNTLRHAVGTMYRSEGPQVFYK 176
+ H V G +A + ++P+D ++TR + Q +P Y + A+ + R+EG +
Sbjct: 73 TTHMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRNVLEALWRIIRTEGLWRPMR 132
Query: 177 GLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYP 236
GL T P L F+CY LK I G N ++ N G A ++ P
Sbjct: 133 GLNVTATGAGPAHALYFACYEKLKKTLSDVIHPGG--NSHIANGAAGCVATLLHDAAMNP 190
Query: 237 LDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALST 296
++ K+R+Q+ + R DC + V Q EGA F++ + L
Sbjct: 191 AEVVKQRMQMYNSPYHRVT-----------DCVRAVWQNEGAGAFYRSYTTQLTMNVPFQ 239
Query: 297 GFMFFSYEFFCNVFHCMNR 315
F +YEF F+ R
Sbjct: 240 AIHFMTYEFLQEHFNPQRR 258
>gi|21389315 solute carrier family 25 (mitochondrial carrier;
citrate transporter), member 1 precursor [Homo sapiens]
Length = 311
Score = 90.9 bits (224), Expect = 1e-18
Identities = 79/289 (27%), Positives = 127/289 (43%), Gaps = 24/289 (8%)
Query: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
+AG ++G + + P + +K + QL RS P +Y GI RQ ++ G +
Sbjct: 30 LAGGLAGGIEICITFPTEYVKTQLQLDE----RSHPP-RYRGIGDCVRQTVRSHGVLGLY 84
Query: 80 KGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCG-GLAACMATLTVHP 138
+G SI AV+F FE L+ H + + +CG G A + V P
Sbjct: 85 RGLSSLLYGSIPKAAVRFGMFEFLSN--HMRDAQGRLDSTRGLLCGLGAGVAEAVVVVCP 142
Query: 139 VDVLRTRFA---AQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSC 195
++ ++ +F PK Y H V + R +G + Y+GL T++ ++F
Sbjct: 143 METIKVKFIHDQTSPNPK-YRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFFV 201
Query: 196 YSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAA 255
+SL++ Y+ P K L + G+ AG S PLD+ K R+Q G E
Sbjct: 202 MTSLRNWYRGDNP--NKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQ--GLE----- 252
Query: 256 FGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
+Y+ DC Q+L+KEG F+KG P L + L +F Y+
Sbjct: 253 ---AHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYD 298
Score = 52.0 bits (123), Expect = 7e-07
Identities = 33/105 (31%), Positives = 48/105 (45%), Gaps = 9/105 (8%)
Query: 206 AIPAEGKKNENLQN--LLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYK 263
A PA GK +L G AG I +T+P + K +LQ+ H RY+
Sbjct: 13 AAPASGKAKLTHPGKAILAGGLAGGIEICITFPTEYVKTQLQLDERSHPP-------RYR 65
Query: 264 GLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYEFFCN 308
G+ DC +Q ++ G LG ++GLS L + F +EF N
Sbjct: 66 GIGDCVRQTVRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSN 110
Score = 50.4 bits (119), Expect = 2e-06
Identities = 43/172 (25%), Positives = 75/172 (43%), Gaps = 8/172 (4%)
Query: 32 LISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFWKGHVPAQILSIG 91
++ P + IK++F H++ S P+ KY G R+I++E+G ++G + A +L G
Sbjct: 139 VVCPMETIKVKFI--HDQTS---PNPKYRGFFHGVREIVREQGLKGTYQG-LTATVLKQG 192
Query: 92 YG-AVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPVDVLRTRFAAQG 150
A++F L + + V G +A + P+DV++TR
Sbjct: 193 SNQAIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQGLE 252
Query: 151 EPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHL 202
K NT + + + EG + FYKG P L + + F Y + L
Sbjct: 253 AHKYRNTWDCGLQIL-KKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKL 303
>gi|86198310 solute carrier family 25, member 29 [Homo sapiens]
Length = 303
Score = 90.9 bits (224), Expect = 1e-18
Identities = 78/281 (27%), Positives = 125/281 (44%), Gaps = 31/281 (11%)
Query: 16 FQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGP 75
F AG V+G++ PFD +K+R Q+Q S +Y G L + I+++E
Sbjct: 5 FLAGCAGGVAGVLVG---HPFDTVKVRLQVQ------SVEKPQYRGTLHCFKSIIKQESV 55
Query: 76 TAFWKG-HVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATL 134
+KG P L+ V + L L H + F+ G A + +
Sbjct: 56 LGLYKGLGSPLMGLTFINALVFGVQGNTLRALGHDSPLNQ-------FLAGAAAGAIQCV 108
Query: 135 TVHPVDVLRTRFAAQ--GEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQ 192
P+++ +TR Q G + Y + +Y EG + +G+ TL+ P G+
Sbjct: 109 ICCPMELAKTRLQLQDAGPARTYKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPSFGVY 168
Query: 193 FSCYSSLKHLYKWAIPAE-GKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEH 251
F Y +L A+ E G + + LL G +G++S TYP+D+ K RLQ G
Sbjct: 169 FLTYDALTR----ALGCEPGDRLLVPKLLLAGGTSGIVSWLSTYPVDVVKSRLQADGLRG 224
Query: 252 ARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKA 292
A RY+G++DC Q + EG F +GL+ +LL+A
Sbjct: 225 A-------PRYRGILDCVHQSYRAEGWRVFTRGLASTLLRA 258
Score = 68.9 bits (167), Expect = 6e-12
Identities = 52/178 (29%), Positives = 84/178 (47%), Gaps = 10/178 (5%)
Query: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
+AG+ +G + + P ++ K R QLQ + P+ Y G L QI EG
Sbjct: 97 LAGAAAGAIQCVICCPMELAKTRLQLQD-----AGPARTYKGSLDCLAQIYGHEGLRGVN 151
Query: 80 KGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPV 139
+G V + V FL+++ LT + D + GG + ++ L+ +PV
Sbjct: 152 RGMVSTLLRETPSFGVYFLTYDALTRALGC-EPGDRLLVPKLLLAGGTSGIVSWLSTYPV 210
Query: 140 DVLRTRFAA---QGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFS 194
DV+++R A +G P+ Y + V YR+EG +VF +GLA TL+ FP F+
Sbjct: 211 DVVKSRLQADGLRGAPR-YRGILDCVHQSYRAEGWRVFTRGLASTLLRAFPVNAATFA 267
Score = 68.6 bits (166), Expect = 7e-12
Identities = 51/195 (26%), Positives = 75/195 (38%), Gaps = 16/195 (8%)
Query: 119 SVHFVCGGLAACMATLTVHPVDVLRTRFAAQG-EPKVYNTLRHAVGTMYRSEGPQVFYKG 177
++ F+ G L HP D ++ R Q E Y H ++ + E YKG
Sbjct: 2 ALDFLAGCAGGVAGVLVGHPFDTVKVRLQVQSVEKPQYRGTLHCFKSIIKQESVLGLYKG 61
Query: 178 LAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPL 237
L L+ + L F + P L L G+ AG I + P+
Sbjct: 62 LGSPLMGLTFINALVFGVQGNTLRALGHDSP--------LNQFLAGAAAGAIQCVICCPM 113
Query: 238 DLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTG 297
+L K RLQ+ G R YKG +DC Q+ EG G +G+ +LL+ S G
Sbjct: 114 ELAKTRLQLQDA-------GPARTYKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPSFG 166
Query: 298 FMFFSYEFFCNVFHC 312
F +Y+ C
Sbjct: 167 VYFLTYDALTRALGC 181
>gi|58197562 solute carrier family 25, member 30 [Homo sapiens]
Length = 291
Score = 90.5 bits (223), Expect = 2e-18
Identities = 70/291 (24%), Positives = 125/291 (42%), Gaps = 22/291 (7%)
Query: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
V G ++ + P D+ K R Q+Q + +Y G+L A +I +EEG A +
Sbjct: 10 VYGGLASITAECGTFPIDLTKTRLQIQGQTNDAKFKEIRYRGMLHALVRIGREEGLKALY 69
Query: 80 KGHVPAQILSIGYGAVQFLSFEMLTEL-VHRGSVYDAREFSVHFVCGGLAACMATLTVHP 138
G PA + YG ++ +++ L L + R + ++ +CG L+ +++ +P
Sbjct: 70 SGIAPAMLRQASYGTIKIGTYQSLKRLFIERP---EDETLPINVICGILSGVISSTIANP 126
Query: 139 VDVLRTRFAAQGEPKVYNTLRHAV----GTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFS 194
DVL+ R AQ NT++ + +Y+ EG + +KG++ T G++
Sbjct: 127 TDVLKIRMQAQS-----NTIQGGMIGNFMNIYQQEGTRGLWKGVSLTAQRAAIVVGVELP 181
Query: 195 CYS-SLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHAR 253
Y + KHL + + L + CG + S P+D+ + R+
Sbjct: 182 VYDITKKHLILSGLMGDTVYTHFLSSFTCGLAGALASN----PVDVVRTRM----MNQRV 233
Query: 254 AAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
G+ Y G +DC Q + EG +KG P+ L+ F +YE
Sbjct: 234 LRDGRCSGYTGTLDCLLQTWKNEGFFALYKGFWPNWLRLGPWNIIFFVTYE 284
Score = 82.4 bits (202), Expect = 5e-16
Identities = 57/184 (30%), Positives = 90/184 (48%), Gaps = 23/184 (12%)
Query: 122 FVCGGLAACMATLTVHPVDVLRTRFAAQGEPK-------VYNTLRHAVGTMYRSEGPQVF 174
FV GGLA+ A P+D+ +TR QG+ Y + HA+ + R EG +
Sbjct: 9 FVYGGLASITAECGTFPIDLTKTRLQIQGQTNDAKFKEIRYRGMLHALVRIGREEGLKAL 68
Query: 175 YKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQ-NLLCGSGAGVISKTL 233
Y G+AP ++ Y ++ Y SLK L+ E ++E L N++CG +GVIS T+
Sbjct: 69 YSGIAPAMLRQASYGTIKIGTYQSLKRLF-----IERPEDETLPINVICGILSGVISSTI 123
Query: 234 TYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAA 293
P D+ K R+Q + G G++ + Q+EG G +KG+S + +AA
Sbjct: 124 ANPTDVLKIRMQA----QSNTIQG------GMIGNFMNIYQQEGTRGLWKGVSLTAQRAA 173
Query: 294 LSTG 297
+ G
Sbjct: 174 IVVG 177
Score = 61.6 bits (148), Expect = 9e-10
Identities = 56/192 (29%), Positives = 89/192 (46%), Gaps = 22/192 (11%)
Query: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
+ G +SG+++ + +P DV+KIR Q Q + G++ I Q+EG W
Sbjct: 111 ICGILSGVISSTIANPTDVLKIRMQAQSNTIQG--------GMIGNFMNIYQQEGTRGLW 162
Query: 80 KG-HVPAQILSIGYGAVQFLSFEMLTE-LVHRGSVYDA--REFSVHFVCGGLAACMATLT 135
KG + AQ +I G V+ +++ + L+ G + D F F CG LA +A+
Sbjct: 163 KGVSLTAQRAAIVVG-VELPVYDITKKHLILSGLMGDTVYTHFLSSFTCG-LAGALAS-- 218
Query: 136 VHPVDVLRTRFAAQ-----GEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAG 190
+PVDV+RTR Q G Y + +++EG YKG P + + P+
Sbjct: 219 -NPVDVVRTRMMNQRVLRDGRCSGYTGTLDCLLQTWKNEGFFALYKGFWPNWLRLGPWNI 277
Query: 191 LQFSCYSSLKHL 202
+ F Y LK L
Sbjct: 278 IFFVTYEQLKKL 289
Score = 43.9 bits (102), Expect = 2e-04
Identities = 23/78 (29%), Positives = 47/78 (60%), Gaps = 2/78 (2%)
Query: 216 NLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQK 275
N + + G A + ++ T+P+DL K RLQ+ G + A F ++ RY+G++ ++ ++
Sbjct: 5 NWKPFVYGGLASITAECGTFPIDLTKTRLQIQG-QTNDAKFKEI-RYRGMLHALVRIGRE 62
Query: 276 EGALGFFKGLSPSLLKAA 293
EG + G++P++L+ A
Sbjct: 63 EGLKALYSGIAPAMLRQA 80
>gi|156071459 solute carrier family 25, member 5 [Homo sapiens]
Length = 298
Score = 90.5 bits (223), Expect = 2e-18
Identities = 67/293 (22%), Positives = 133/293 (45%), Gaps = 21/293 (7%)
Query: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
+AG V+ +++ ++P + +K+ Q+QH + +Y GI+ +I +E+G +FW
Sbjct: 13 LAGGVAAAISKTAVAPIERVKLLLQVQHAS-KQITADKQYKGIIDCVVRIPKEQGVLSFW 71
Query: 80 KGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFV----CGGLAACMATLT 135
+G++ I A+ F +F+ + + G V +F ++F GG A +
Sbjct: 72 RGNLANVIRYFPTQALNF-AFKDKYKQIFLGGVDKRTQFWLYFAGNLASGGAAGATSLCF 130
Query: 136 VHPVDVLRTRFAAQ----GEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGL 191
V+P+D RTR AA G + + L + +Y+S+G + Y+G ++ I Y
Sbjct: 131 VYPLDFARTRLAADVGKAGAEREFRGLGDCLVKIYKSDGIKGLYQGFNVSVQGIIIYRAA 190
Query: 192 QFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEH 251
F Y + K + + K + + + ++ +YP D ++R+ +
Sbjct: 191 YFGIYDTAKGMLP-----DPKNTHIVISWMIAQTVTAVAGLTSYPFDTVRRRMMMQSGRK 245
Query: 252 ARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
G Y G +DC +++ + EG FFKG ++L+ + F+ Y+
Sbjct: 246 -----GTDIMYTGTLDCWRKIARDEGGKAFFKGAWSNVLR-GMGGAFVLVLYD 292
Score = 58.9 bits (141), Expect = 6e-09
Identities = 46/185 (24%), Positives = 81/185 (43%), Gaps = 18/185 (9%)
Query: 115 AREFSVHFVCGGLAACMATLTVHPVDVLRTRFAAQ------GEPKVYNTLRHAVGTMYRS 168
A F+ F+ GG+AA ++ V P++ ++ Q K Y + V + +
Sbjct: 5 AVSFAKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVRIPKE 64
Query: 169 EGPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNE----NLQNLLCGS 224
+G F++G +I FP L F+ K ++ + K+ + NL G
Sbjct: 65 QGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGV---DKRTQFWLYFAGNLASGG 121
Query: 225 GAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKG 284
AG S YPLD + RL + +A G R ++GL DC ++ + +G G ++G
Sbjct: 122 AAGATSLCFVYPLDFARTRLAA---DVGKA--GAEREFRGLGDCLVKIYKSDGIKGLYQG 176
Query: 285 LSPSL 289
+ S+
Sbjct: 177 FNVSV 181
>gi|6031192 solute carrier family 25 member 3 isoform a precursor
[Homo sapiens]
Length = 362
Score = 89.0 bits (219), Expect = 5e-18
Identities = 78/294 (26%), Positives = 130/294 (44%), Gaps = 38/294 (12%)
Query: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
+ G +S T + P D++K R Q+ DP KY GI L+E+G
Sbjct: 70 LGGIISCGTTHTALVPLDLVKCRMQV--------DPQ-KYKGIFNGFSVTLKEDGVRGLA 120
Query: 80 KGHVPAQILSIGYGAVQFLSFEML----TELVHRGSVYDAREFSVHFVCGGLAACMATLT 135
KG P + G +F +E+ + ++ + Y R S++ A A +
Sbjct: 121 KGWAPTFLGYSMQGLCKFGFYEVFKVLYSNMLGEENTYLWRT-SLYLAASASAEFFADIA 179
Query: 136 VHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSC 195
+ P++ + R Q +P NTLR A MY+ EG + FYKG+AP + PY ++F+C
Sbjct: 180 LAPMEAAKVRI--QTQPGYANTLRDAAPKMYKEEGLKAFYKGVAPLWMRQIPYTMMKFAC 237
Query: 196 YS-SLKHLYKWAIP---AEGKKNENL-QNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFE 250
+ +++ LYK+ +P +E K E L + G AGV +++P D
Sbjct: 238 FERTVEALYKFVVPKPRSECSKPEQLVVTFVAGYIAGVFCAIVSHPAD------------ 285
Query: 251 HARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
+ + + KG A VL++ G G +KGL ++ T +F Y+
Sbjct: 286 ---SVVSVLNKEKG--SSASLVLKRLGFKGVWKGLFARIIMIGTLTALQWFIYD 334
Score = 50.8 bits (120), Expect = 2e-06
Identities = 53/219 (24%), Positives = 88/219 (40%), Gaps = 33/219 (15%)
Query: 14 TKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEE 73
T +A + S AL +P + K+R Q Q + + A+ ++ +EE
Sbjct: 162 TSLYLAASASAEFFADIAL-APMEAAKVRIQTQ---------PGYANTLRDAAPKMYKEE 211
Query: 74 GPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAR-------EFSVHFVCGG 126
G AF+KG P + I Y ++F FE E +++ V R + V FV G
Sbjct: 212 GLKAFYKGVAPLWMRQIPYTMMKFACFERTVEALYKFVVPKPRSECSKPEQLVVTFVAGY 271
Query: 127 LAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGT----MYRSEGPQVFYKGLAPTL 182
+A + HP D V + L G+ + + G + +KGL +
Sbjct: 272 IAGVFCAIVSHPAD------------SVVSVLNKEKGSSASLVLKRLGFKGVWKGLFARI 319
Query: 183 IAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLL 221
I I LQ+ Y S+K ++ P + E+L+ L
Sbjct: 320 IMIGTLTALQWFIYDSVKVYFRLPRPPPPEMPESLKKKL 358
>gi|4507807 uncoupling protein 3 isoform UCP3L [Homo sapiens]
Length = 312
Score = 89.0 bits (219), Expect = 5e-18
Identities = 63/196 (32%), Positives = 94/196 (47%), Gaps = 8/196 (4%)
Query: 8 PDGRNNTKFQVAV-AGSVSGLVTRALISPFDVIKIRFQLQ-HERLSRSDPSAKYHGILQA 65
P G +N+ + AG +G + P DV+K+RFQ H SRSD KY G + A
Sbjct: 108 PKGADNSSLTTRILAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSD--RKYSGTMDA 165
Query: 66 SRQILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTE-LVHRGSVYDAREFSVHFVC 124
R I +EEG WKG +P + + + +++++L E L+ + D F HFV
Sbjct: 166 YRTIAREEGVRGLWKGTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTD--NFPCHFVS 223
Query: 125 GGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIA 184
A AT+ PVDV++TR+ P Y + + M EGP FYKG P+ +
Sbjct: 224 AFGAGFCATVVASPVDVVKTRYM-NSPPGQYFSPLDCMIKMVAQEGPTAFYKGFTPSFLR 282
Query: 185 IFPYAGLQFSCYSSLK 200
+ + + F Y LK
Sbjct: 283 LGSWNVVMFVTYEQLK 298
Score = 82.0 bits (201), Expect = 6e-16
Identities = 56/185 (30%), Positives = 86/185 (46%), Gaps = 16/185 (8%)
Query: 119 SVHFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLR--------HAVGTMYRSEG 170
+V F+ G AAC A L P+D + R QGE + T R + TM R+EG
Sbjct: 14 AVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEG 73
Query: 171 PQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENL-QNLLCGSGAGVI 229
P Y GL L +A ++ Y S+K +Y +G N +L +L G G +
Sbjct: 74 PCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVY----TPKGADNSSLTTRILAGCTTGAM 129
Query: 230 SKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSL 289
+ T P D+ K R Q H + R+Y G MD + + ++EG G +KG P++
Sbjct: 130 AVTCAQPTDVVKVRFQAS--IHLGPSRSD-RKYSGTMDAYRTIAREEGVRGLWKGTLPNI 186
Query: 290 LKAAL 294
++ A+
Sbjct: 187 MRNAI 191
Score = 72.4 bits (176), Expect = 5e-13
Identities = 65/283 (22%), Positives = 116/283 (40%), Gaps = 33/283 (11%)
Query: 35 PFDVIKIRFQLQHERLS-RSDPSAKYHGILQASRQILQEEGPTAFWKGHVPAQILSIGYG 93
P D K+R Q+Q E + ++ +Y G+L +++ EGP + + G V + +
Sbjct: 33 PLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSPYNGLVAGLQRQMSFA 92
Query: 94 AVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPVDVLRTRFAAQ---- 149
+++ ++ + + V+ D + + G MA P DV++ RF A
Sbjct: 93 SIRIGLYDSVKQ-VYTPKGADNSSLTTRILAGCTTGAMAVTCAQPTDVVKVRFQASIHLG 151
Query: 150 --GEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSLK------H 201
+ Y+ A T+ R EG + +KG P ++ + Y LK H
Sbjct: 152 PSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAEVVTYDILKEKLLDYH 211
Query: 202 LYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRR 261
L P + + GAG + + P+D+ K R + + GQ
Sbjct: 212 LLTDNFPC---------HFVSAFGAGFCATVVASPVDVVKTR-------YMNSPPGQ--- 252
Query: 262 YKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
Y +DC +++ +EG F+KG +PS L+ MF +YE
Sbjct: 253 YFSPLDCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYE 295
>gi|7657585 mitochondrial ornithine transporter 1 [Homo sapiens]
Length = 301
Score = 88.6 bits (218), Expect = 7e-18
Identities = 74/311 (23%), Positives = 131/311 (42%), Gaps = 39/311 (12%)
Query: 11 RNNTKFQVAV---AGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASR 67
++N Q A+ AG+ G PFD +K++ Q + Y G+
Sbjct: 2 KSNPAIQAAIDLTAGAAGGTACVLTGQPFDTMKVKMQTFPDL---------YRGLTDCCL 52
Query: 68 QILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAR---EFSVHFVC 124
+ + G F+KG PA I +I +V F+ + ++V + + D + +
Sbjct: 53 KTYSQVGFRGFYKGTSPALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAA 112
Query: 125 GGLAACMATLTVHPVDVLRTRFAAQGE-------PKVYNTLRHAVGTMYRSEGPQVFYKG 177
G A+ A L + P ++++ R E K NT+ + ++ R +GP FY G
Sbjct: 113 GSFASAFAALVLCPTELVKCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHG 172
Query: 178 LAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQN---LLCGSGAGVISKTLT 234
L+ TL+ P F Y + + A G+ + L +L G G+
Sbjct: 173 LSSTLLREVPGYFFFFGGYELSRSFF-----ASGRSKDELGPVPLMLSGGVGGICLWLAV 227
Query: 235 YPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAAL 294
YP+D K R+QV +A F +R + V++ EG + GL P++++A
Sbjct: 228 YPVDCIKSRIQVLSMSGKQAGF--IRTFIN-------VVKNEGITALYSGLKPTMIRAFP 278
Query: 295 STGFMFFSYEF 305
+ G +F +YE+
Sbjct: 279 ANGALFLAYEY 289
Score = 71.6 bits (174), Expect = 9e-13
Identities = 54/198 (27%), Positives = 86/198 (43%), Gaps = 7/198 (3%)
Query: 115 AREFSVHFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVF 174
A + ++ G LT P D ++ + Q P +Y L Y G + F
Sbjct: 6 AIQAAIDLTAGAAGGTACVLTGQPFDTMKVKM--QTFPDLYRGLTDCCLKTYSQVGFRGF 63
Query: 175 YKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGK-KNENLQNLLCGSGAGVISKTL 233
YKG +P LIA + F CY + + + + + K +LQN GS A + +
Sbjct: 64 YKGTSPALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFAALV 123
Query: 234 TYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLM-DCAKQVLQKEGALGFFKGLSPSLLKA 292
P +L K RLQ + G++ + + + K +L+K+G LGF+ GLS +LL+
Sbjct: 124 LCPTELVKCRLQT---MYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLRE 180
Query: 293 ALSTGFMFFSYEFFCNVF 310
F F YE + F
Sbjct: 181 VPGYFFFFGGYELSRSFF 198
Score = 58.9 bits (141), Expect = 6e-09
Identities = 42/186 (22%), Positives = 73/186 (39%)
Query: 17 QVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPT 76
Q A AGS + ++ P +++K R Q +E + + + + + IL+++GP
Sbjct: 108 QNAAAGSFASAFAALVLCPTELVKCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPL 167
Query: 77 AFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTV 136
F+ G + + F +E+ G D + GG+ L V
Sbjct: 168 GFYHGLSSTLLREVPGYFFFFGGYELSRSFFASGRSKDELGPVPLMLSGGVGGICLWLAV 227
Query: 137 HPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCY 196
+PVD +++R + ++EG Y GL PT+I FP G F Y
Sbjct: 228 YPVDCIKSRIQVLSMSGKQAGFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAY 287
Query: 197 SSLKHL 202
+ L
Sbjct: 288 EYSRKL 293
Score = 35.8 bits (81), Expect = 0.052
Identities = 23/88 (26%), Positives = 39/88 (44%), Gaps = 7/88 (7%)
Query: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
++G V G+ + P D IK R Q+ S K G ++ +++ EG TA +
Sbjct: 214 LSGGVGGICLWLAVYPVDCIKSRIQVL-------SMSGKQAGFIRTFINVVKNEGITALY 266
Query: 80 KGHVPAQILSIGYGAVQFLSFEMLTELV 107
G P I + FL++E +L+
Sbjct: 267 SGLKPTMIRAFPANGALFLAYEYSRKLM 294
>gi|4505775 solute carrier family 25 member 3 isoform b precursor
[Homo sapiens]
Length = 361
Score = 88.6 bits (218), Expect = 7e-18
Identities = 78/292 (26%), Positives = 130/292 (44%), Gaps = 38/292 (13%)
Query: 22 GSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFWKG 81
G +S +T + P D++K R Q+ DP KY GI L+E+G KG
Sbjct: 71 GVLSCGLTHTAVVPLDLVKCRMQV--------DPQ-KYKGIFNGFSVTLKEDGVRGLAKG 121
Query: 82 HVPAQILSIGYGAVQFLSFEML----TELVHRGSVYDAREFSVHFVCGGLAACMATLTVH 137
P + G +F +E+ + ++ + Y R S++ A A + +
Sbjct: 122 WAPTFLGYSMQGLCKFGFYEVFKVLYSNMLGEENTYLWRT-SLYLAASASAEFFADIALA 180
Query: 138 PVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYS 197
P++ + R Q +P NTLR A MY+ EG + FYKG+AP + PY ++F+C+
Sbjct: 181 PMEAAKVRI--QTQPGYANTLRDAAPKMYKEEGLKAFYKGVAPLWMRQIPYTMMKFACFE 238
Query: 198 -SLKHLYKWAIP---AEGKKNENL-QNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHA 252
+++ LYK+ +P +E K E L + G AGV +++P D
Sbjct: 239 RTVEALYKFVVPKPRSECSKPEQLVVTFVAGYIAGVFCAIVSHPAD-------------- 284
Query: 253 RAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
+ + + KG A VL++ G G +KGL ++ T +F Y+
Sbjct: 285 -SVVSVLNKEKG--SSASLVLKRLGFKGVWKGLFARIIMIGTLTALQWFIYD 333
Score = 50.8 bits (120), Expect = 2e-06
Identities = 53/219 (24%), Positives = 88/219 (40%), Gaps = 33/219 (15%)
Query: 14 TKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEE 73
T +A + S AL +P + K+R Q Q + + A+ ++ +EE
Sbjct: 161 TSLYLAASASAEFFADIAL-APMEAAKVRIQTQ---------PGYANTLRDAAPKMYKEE 210
Query: 74 GPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAR-------EFSVHFVCGG 126
G AF+KG P + I Y ++F FE E +++ V R + V FV G
Sbjct: 211 GLKAFYKGVAPLWMRQIPYTMMKFACFERTVEALYKFVVPKPRSECSKPEQLVVTFVAGY 270
Query: 127 LAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGT----MYRSEGPQVFYKGLAPTL 182
+A + HP D V + L G+ + + G + +KGL +
Sbjct: 271 IAGVFCAIVSHPAD------------SVVSVLNKEKGSSASLVLKRLGFKGVWKGLFARI 318
Query: 183 IAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLL 221
I I LQ+ Y S+K ++ P + E+L+ L
Sbjct: 319 IMIGTLTALQWFIYDSVKVYFRLPRPPPPEMPESLKKKL 357
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.138 0.421
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,797,645
Number of Sequences: 37866
Number of extensions: 485990
Number of successful extensions: 1731
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 71
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 993
Number of HSP's gapped (non-prelim): 256
length of query: 320
length of database: 18,247,518
effective HSP length: 102
effective length of query: 218
effective length of database: 14,385,186
effective search space: 3135970548
effective search space used: 3135970548
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.