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Search of human proteins with 170784844
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
(564 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens] 1162 0.0
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 1125 0.0
gi|166235129 kelch-like 3 [Homo sapiens] 306 4e-83
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 301 8e-82
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 301 8e-82
gi|38194229 kelch-like 17 [Homo sapiens] 301 8e-82
gi|40807500 kelch-like 20 [Homo sapiens] 291 8e-79
gi|55925604 kelch-like 18 [Homo sapiens] 291 1e-78
gi|11056006 kelch-like 12 [Homo sapiens] 288 9e-78
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 271 1e-72
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 265 8e-71
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 265 1e-70
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 265 1e-70
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 261 2e-69
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 261 2e-69
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 260 3e-69
gi|14780904 kelch-like 1 protein [Homo sapiens] 259 5e-69
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 257 2e-68
gi|34101268 kelch-like 8 [Homo sapiens] 241 1e-63
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 241 2e-63
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 239 5e-63
gi|148664209 kelch-like 10 [Homo sapiens] 233 3e-61
gi|223890235 intracisternal A particle-promoted polypeptide isof... 233 3e-61
gi|40018614 DRE1 protein [Homo sapiens] 215 1e-55
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo... 206 4e-53
gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 206 5e-53
gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain contai... 206 5e-53
gi|8922854 kelch-like 26 [Homo sapiens] 205 1e-52
gi|109150407 kelch-like 6 [Homo sapiens] 199 7e-51
gi|45643138 kelch-like 13 [Homo sapiens] 197 2e-50
>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
Length = 564
Score = 1162 bits (3006), Expect = 0.0
Identities = 564/564 (100%), Positives = 564/564 (100%)
Query: 1 MLGGTDCRTFLTSHINLKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKS 60
MLGGTDCRTFLTSHINLKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKS
Sbjct: 1 MLGGTDCRTFLTSHINLKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKS 60
Query: 61 FEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVD 120
FEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVD
Sbjct: 61 FEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVD 120
Query: 121 ASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVR 180
ASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVR
Sbjct: 121 ASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVR 180
Query: 181 AEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKM 240
AEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKM
Sbjct: 181 AEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKM 240
Query: 241 VISGMRYHLLSPEDREELVDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCP 300
VISGMRYHLLSPEDREELVDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCP
Sbjct: 241 VISGMRYHLLSPEDREELVDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCP 300
Query: 301 FEKRRDAACVFWDNVVYILGGSQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEG 360
FEKRRDAACVFWDNVVYILGGSQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEG
Sbjct: 301 FEKRRDAACVFWDNVVYILGGSQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEG 360
Query: 361 KIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNN 420
KIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNN
Sbjct: 361 KIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNN 420
Query: 421 VSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYD 480
VSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYD
Sbjct: 421 VSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYD 480
Query: 481 IKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVR 540
IKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVR
Sbjct: 481 IKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVR 540
Query: 541 AFPVTSCLICVVDTCGANEETLET 564
AFPVTSCLICVVDTCGANEETLET
Sbjct: 541 AFPVTSCLICVVDTCGANEETLET 564
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 1125 bits (2911), Expect = 0.0
Identities = 546/552 (98%), Positives = 550/552 (99%)
Query: 13 SHINLKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDI 72
+++ +KTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDI
Sbjct: 35 NNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDI 94
Query: 73 IEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAE 132
IEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAE
Sbjct: 95 IEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAE 154
Query: 133 CLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRW 192
CLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRW
Sbjct: 155 CLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRW 214
Query: 193 LKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSP 252
LKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSP
Sbjct: 215 LKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSP 274
Query: 253 EDREELVDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFW 312
EDREELVDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFW
Sbjct: 275 EDREELVDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFW 334
Query: 313 DNVVYILGGSQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGN 372
DNVVYILGGSQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGN
Sbjct: 335 DNVVYILGGSQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGN 394
Query: 373 SALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVY 432
SALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVY
Sbjct: 395 SALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVY 454
Query: 433 DPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPM 492
DPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPM
Sbjct: 455 DPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPM 514
Query: 493 PWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVRAFPVTSCLICVV 552
PWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVRAFPVTSCLICVV
Sbjct: 515 PWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVRAFPVTSCLICVV 574
Query: 553 DTCGANEETLET 564
DTCGANEETLET
Sbjct: 575 DTCGANEETLET 586
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 306 bits (783), Expect = 4e-83
Identities = 182/528 (34%), Positives = 282/528 (53%), Gaps = 11/528 (2%)
Query: 13 SHINLKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDI 72
+ + K+ LCDV+++ ++ +I AHRVVLAA S +F MFT +M ESK+ ++E+KD +
Sbjct: 41 NELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQT 100
Query: 73 IEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAE 132
+ +L+++ YTA I V NVQ LL AA+ Q+ V++ C DFL+ Q+ +NCLGI A+
Sbjct: 101 LSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFAD 160
Query: 133 CLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRW 192
C +L A+ + QHF EV +EFL L + +V L++ D LTV +E++V++A + W
Sbjct: 161 VHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISW 220
Query: 193 LKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSP 252
+ Y++ R M ++ VR PL+ +++L +TV+ E LI++N C +I M+YHLL P
Sbjct: 221 INYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLL-P 279
Query: 253 EDREELVDG--TRPRRKKHDYRIAL-FGGSQPQSCRYFNPKDYS---WTDIRCPFEKRRD 306
D+ L+ T+PR ++ + GG P++ R D+ W I +R
Sbjct: 280 LDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCR 339
Query: 307 AACVFWDNVVYILGG-SQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTS 365
A VF VY +GG + ++ +D Y+ VKD W S R +L A +Y
Sbjct: 340 AGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAV 399
Query: 366 GGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRV 425
GG + G++ L E Y +T W M T+R S G+ G +Y GG G S +
Sbjct: 400 GGFD-GSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDG--ASRQC 456
Query: 426 LNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNE 485
L++ E Y+PAT W + M R G+ + +++A GG +G +VE YD N
Sbjct: 457 LSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVEVYDPGTNT 516
Query: 486 WKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 533
WK V+ M AV ++YV+ G G L + YN TDKW
Sbjct: 517 WKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKW 564
Score = 36.2 bits (82), Expect = 0.082
Identities = 18/76 (23%), Positives = 34/76 (44%)
Query: 460 KIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGR 519
K+ V G + +VE YD + + W ++ +P + + VY + GF G R
Sbjct: 301 KVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLR 360
Query: 520 LGHILEYNTETDKWVA 535
+ + Y+ D+W +
Sbjct: 361 VRTVDVYDGVKDQWTS 376
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 301 bits (772), Expect = 8e-82
Identities = 175/548 (31%), Positives = 289/548 (52%), Gaps = 11/548 (2%)
Query: 13 SHINLKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDI 72
+ + + LCDV ++ ++ +I AHRVVLAA S +F+ MFT M ES++ V +K+ +
Sbjct: 51 NELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWT 110
Query: 73 IEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAE 132
+ L+++ YTA I V NVQ LL AA Q++ VKK C +FL+ Q+ NCLGI A+
Sbjct: 111 LRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFAD 170
Query: 133 CLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRW 192
C +L A+ + QHF +V ++EFL L +++V L++ D LT+ +E++V++A + W
Sbjct: 171 MHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAW 230
Query: 193 LKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSP 252
+ +D+ RQ FM ++ VR PL+ + +L + V+ E L++++ C +I M+YHLL P
Sbjct: 231 VNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLL-P 289
Query: 253 EDREELVDGTRPRRK---KHDYRIALFGGSQPQSCR---YFNPKDYSWTDIRCPFEKRRD 306
++ L+ R R + + + GG P++ R ++ K+ W + +R
Sbjct: 290 TEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCR 349
Query: 307 AACVFWDNVVYILGG-SQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTS 365
A V+ +V+ +GG + ++ +D Y+ VKD W S R +L A G +Y
Sbjct: 350 AGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAV 409
Query: 366 GGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRV 425
GG + G++ L E Y+ ++ W M T+R S G+ GL+Y GG G S +
Sbjct: 410 GGFD-GSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDG--ASRQC 466
Query: 426 LNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNE 485
L++ E Y+ T WT + M R G+ + + ++AVGG +G +VE YD N
Sbjct: 467 LSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNA 526
Query: 486 WKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVRAFPVT 545
W+ V+ M AV ++YV+ G G L + YN TDKW S + +
Sbjct: 527 WRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRS 586
Query: 546 SCLICVVD 553
+ V+D
Sbjct: 587 YAGVTVID 594
Score = 63.5 bits (153), Expect = 5e-10
Identities = 53/195 (27%), Positives = 79/195 (40%), Gaps = 11/195 (5%)
Query: 271 YRIALFGGSQP-QSCRYFNPKDYSWTDIRCPFEKRRDAACV-FWDNVVYILGG---SQLF 325
Y + F GS S +N K W + P RR + V ++Y +GG +
Sbjct: 407 YAVGGFDGSTGLSSVEAYNIKSNEWFHV-APMNTRRSSVGVGVVGGLLYAVGGYDGASRQ 465
Query: 326 PIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRT 385
+ ++CYN + W T R +Y GG + G E YD T
Sbjct: 466 CLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHD-GPLVRKSVEVYDPTT 524
Query: 386 ESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPM 445
+W M R + G+ NGL+YV GG G+ L S E Y+P T+ WT +
Sbjct: 525 NAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCN----LASVEYYNPTTDKWTVVSSC 580
Query: 446 IEARKNHGLVFVKDK 460
+ +++ V V DK
Sbjct: 581 MSTGRSYAGVTVIDK 595
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 301 bits (772), Expect = 8e-82
Identities = 175/548 (31%), Positives = 289/548 (52%), Gaps = 11/548 (2%)
Query: 13 SHINLKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDI 72
+ + + LCDV ++ ++ +I AHRVVLAA S +F+ MFT M ES++ V +K+ +
Sbjct: 47 NELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWT 106
Query: 73 IEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAE 132
+ L+++ YTA I V NVQ LL AA Q++ VKK C +FL+ Q+ NCLGI A+
Sbjct: 107 LRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFAD 166
Query: 133 CLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRW 192
C +L A+ + QHF +V ++EFL L +++V L++ D LT+ +E++V++A + W
Sbjct: 167 MHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAW 226
Query: 193 LKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSP 252
+ +D+ RQ FM ++ VR PL+ + +L + V+ E L++++ C +I M+YHLL P
Sbjct: 227 VNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLL-P 285
Query: 253 EDREELVDGTRPRRK---KHDYRIALFGGSQPQSCR---YFNPKDYSWTDIRCPFEKRRD 306
++ L+ R R + + + GG P++ R ++ K+ W + +R
Sbjct: 286 TEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCR 345
Query: 307 AACVFWDNVVYILGG-SQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTS 365
A V+ +V+ +GG + ++ +D Y+ VKD W S R +L A G +Y
Sbjct: 346 AGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAV 405
Query: 366 GGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRV 425
GG + G++ L E Y+ ++ W M T+R S G+ GL+Y GG G S +
Sbjct: 406 GGFD-GSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDG--ASRQC 462
Query: 426 LNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNE 485
L++ E Y+ T WT + M R G+ + + ++AVGG +G +VE YD N
Sbjct: 463 LSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNA 522
Query: 486 WKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVRAFPVT 545
W+ V+ M AV ++YV+ G G L + YN TDKW S + +
Sbjct: 523 WRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRS 582
Query: 546 SCLICVVD 553
+ V+D
Sbjct: 583 YAGVTVID 590
Score = 63.5 bits (153), Expect = 5e-10
Identities = 53/195 (27%), Positives = 79/195 (40%), Gaps = 11/195 (5%)
Query: 271 YRIALFGGSQP-QSCRYFNPKDYSWTDIRCPFEKRRDAACV-FWDNVVYILGG---SQLF 325
Y + F GS S +N K W + P RR + V ++Y +GG +
Sbjct: 403 YAVGGFDGSTGLSSVEAYNIKSNEWFHV-APMNTRRSSVGVGVVGGLLYAVGGYDGASRQ 461
Query: 326 PIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRT 385
+ ++CYN + W T R +Y GG + G E YD T
Sbjct: 462 CLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHD-GPLVRKSVEVYDPTT 520
Query: 386 ESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPM 445
+W M R + G+ NGL+YV GG G+ L S E Y+P T+ WT +
Sbjct: 521 NAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCN----LASVEYYNPTTDKWTVVSSC 576
Query: 446 IEARKNHGLVFVKDK 460
+ +++ V V DK
Sbjct: 577 MSTGRSYAGVTVIDK 591
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 301 bits (772), Expect = 8e-82
Identities = 181/532 (34%), Positives = 285/532 (53%), Gaps = 13/532 (2%)
Query: 13 SHINLKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDI 72
S + + LCD++L V ++I AH+VVLA+ S +F+ MFT M ES+ V L D +P
Sbjct: 83 SRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQA 142
Query: 73 IEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAE 132
++QLV+FAYTA I V NVQ+LL AA+ Q+ V+ C FL Q+D SNCLGI A+
Sbjct: 143 LDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFAD 202
Query: 133 CLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRW 192
C +L A ++ QHF +V KT+EF+ L +K+V L++ D+L V +E++VY A + W
Sbjct: 203 AHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEEVYRAVLSW 262
Query: 193 LKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSP 252
+K+D R+ + ++ VR PL+S++FL V AE L++ +P+C ++I +++HLL P
Sbjct: 263 VKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLL-P 321
Query: 253 EDREEL-VDGTRPRRKK--HDYRIALFGGSQ---PQSCRYFNPKDYSWTDIRCPFEKRRD 306
E R L TRPRR + A+ GGS C ++ + W + +R
Sbjct: 322 EQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVVASMSTRRAR 381
Query: 307 AACVFWDNVVYILGG-SQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTS 365
N +Y +GG + ++ Y+ V ++W ++ T R L A G +Y++
Sbjct: 382 VGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYSA 441
Query: 366 GGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRV 425
GG + G S L E YD T +W + +M T+R + +G +Y GG S
Sbjct: 442 GGYD-GASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGG----YDSSSH 496
Query: 426 LNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNE 485
L + E Y+P W+ + M+ R + G+ ++ ++ GG +G L++VE Y K
Sbjct: 497 LATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGA 556
Query: 486 WKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANS 537
W+ V+PM + T A+ +Y + G G L I +YN T+KWVA S
Sbjct: 557 WESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAAS 608
Score = 70.9 bits (172), Expect = 3e-12
Identities = 49/186 (26%), Positives = 81/186 (43%), Gaps = 12/186 (6%)
Query: 277 GGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGG----SQLFPIKRMDC 332
G S S ++P +WT + +RR D +Y +GG S L +++
Sbjct: 446 GASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEK--- 502
Query: 333 YNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKP 392
Y + W + R S EG +Y +GG++ G S L E Y + +W +
Sbjct: 503 YEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGND-GTSCLNSVERYSPKAGAWESVA 561
Query: 393 SMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNH 452
M +R +H +V +G +Y GG+ G++ LNS E Y+P T W M R +
Sbjct: 562 PMNIRRSTHDLVAMDGWLYAVGGNDGSSS----LNSIEKYNPRTNKWVAASCMFTRRSSV 617
Query: 453 GLVFVK 458
G+ ++
Sbjct: 618 GVAVLE 623
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 291 bits (746), Expect = 8e-79
Identities = 179/527 (33%), Positives = 279/527 (52%), Gaps = 22/527 (4%)
Query: 19 KTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVE 78
+ LCDV+L+V +KI AHRV+L+A S +F MFT + ES+ EV ++D + +E L++
Sbjct: 65 RELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLID 124
Query: 79 FAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPE 138
FAYT++I+V NVQ+LL AA Q+ +++ C +FLK Q+D SNCLGI A+ C E
Sbjct: 125 FAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFADTHSCRE 184
Query: 139 LKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEP 198
L AD F +F EV +++EF+ L ++ +++ D L VR+E+QV++A + W+KY
Sbjct: 185 LLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQ 244
Query: 199 NRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREEL 258
R+P + +L VR PL+S FL TV ++PLI+ + EC +V Y LL P++R L
Sbjct: 245 ERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNY-LLLPQER-PL 302
Query: 259 VDGTRPRRKK----HDYRIALFG---GSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVF 311
+ G R R +K + A+ G G S ++P+ W + ++R
Sbjct: 303 MQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSV 362
Query: 312 WDNVVYILGG----SQLFPIKRMDCYNVVKDSWYSKLGP-PTPRDSLAACAAEGKIYTSG 366
D+++Y +GG S L ++R Y+ + W S + P T R S+ G +Y G
Sbjct: 363 LDDLLYAVGGHDGSSYLNSVER---YDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVG 419
Query: 367 GSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVL 426
G + G S L + E YD + W SM T+R + G +Y GGS G + L
Sbjct: 420 GQD-GVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTS----PL 474
Query: 427 NSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEW 486
N+ E Y+P W + PM RK+ G +D I+AVGG++ L + E Y+ + N+W
Sbjct: 475 NTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQW 534
Query: 487 KMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 533
V M + V A V + + GF G L I ++ + + W
Sbjct: 535 SPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTW 581
Score = 68.6 bits (166), Expect = 1e-11
Identities = 50/187 (26%), Positives = 77/187 (41%), Gaps = 10/187 (5%)
Query: 277 GGSQPQSC----RYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQ-LFPIKRMD 331
GG SC ++PK+ WT + +R A +Y +GGS P+ ++
Sbjct: 419 GGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVE 478
Query: 332 CYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTK 391
YN ++ W++ T R L + IY GG + + L E Y+ RT W
Sbjct: 479 RYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRD-DTTELSSAERYNPRTNQWSPV 537
Query: 392 PSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKN 451
+M ++R G+ NG + GG G L + EV+DP TW M R
Sbjct: 538 VAMTSRRSGVGLAVVNGQLMAVGGFDGTTY----LKTIEVFDPDANTWRLYGGMNYRRLG 593
Query: 452 HGLVFVK 458
G+ +K
Sbjct: 594 GGVGVIK 600
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 291 bits (745), Expect = 1e-78
Identities = 172/521 (33%), Positives = 266/521 (51%), Gaps = 14/521 (2%)
Query: 21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFA 80
LCDV L + + K AHR+VLAA+ +F+ MFT +M+E K E+ ++ +P +E L+ FA
Sbjct: 37 LCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFA 96
Query: 81 YTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELK 140
Y ++++ NVQSLL A+ Q++ +K C FL+E++ NCLG+ AE + C L
Sbjct: 97 YNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFAETMMCAVLY 156
Query: 141 ATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNR 200
A+ FIHQHF EV ++EFL L ++ V L+++D L V++E+QV++AA+ W++YD R
Sbjct: 157 DAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQR 216
Query: 201 QPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREEL-V 259
P++ ++L+ +R PL FLS VQ + L++ +C +V YHL+ PE R L
Sbjct: 217 GPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLM-PERRPHLPA 275
Query: 260 DGTRPR--RKKHDYRIALFG----GSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWD 313
TRPR A+ G G F+P W R R +
Sbjct: 276 FRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVN 335
Query: 314 NVVYILGG-SQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGN 372
++Y +GG + ++ YN D+W + R ++ +G+IY GG + GN
Sbjct: 336 GLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYD-GN 394
Query: 373 SALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVY 432
S+L E Y T+ W SM + R + G+ G IYV GG G ++ +S E Y
Sbjct: 395 SSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGL----QIFSSVEHY 450
Query: 433 DPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPM 492
+ T TW M+ R HG + K+F GG +G G L E Y ++W ++ PM
Sbjct: 451 NHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQWCLIVPM 510
Query: 493 PWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 533
+ V A +Y + G+ G L + Y+ ETD W
Sbjct: 511 HTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCW 551
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 288 bits (737), Expect = 9e-78
Identities = 184/546 (33%), Positives = 285/546 (52%), Gaps = 21/546 (3%)
Query: 1 MLGGTDCRTFLTSHINLKK--TLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLES 58
++ T ++ L S +L+K TLCDV L V+++ PAHR+VLAA S +F MFT+ + E
Sbjct: 10 IMTNTHAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEK 69
Query: 59 KSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQ 118
V+++ +E L++F YT + V NVQ LL AA Q++ VK+ C +FL+ Q
Sbjct: 70 GKPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQ 129
Query: 119 VDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLT 178
+D SNCLGI AE +C +L A+ F +HF EV + +EF+ L V L+ D +
Sbjct: 130 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQ 189
Query: 179 VRAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECL 238
V +E+ V++A + W+K+ + R+ + ++L VR PL++ +++ + AEP I+ + +C
Sbjct: 190 VDSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCR 249
Query: 239 KMVISGMRYHLLSPEDREELV-DGTRPRRKKHDYRIALFGGSQPQS----CRYFNPKDYS 293
+V ++H L PE R ++ TR R ++ + + G QS ++PK
Sbjct: 250 DLVDEAKKFH-LRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQE 308
Query: 294 WTDIRCPFEKRRDAACVFWDNVVYILGG----SQLFPIKRMDCYNVVKDS-WYSKLGPPT 348
W+ + KRR A V + +Y++GG S+L ++ +D Y +D WYS + P
Sbjct: 309 WSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLD-YTADEDGVWYS-VAPMN 366
Query: 349 PRDSLAACAAEG-KIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEAN 407
R LA G IY SGG + G+ E YD + W M T R G+V A+
Sbjct: 367 VRRGLAGATTLGDMIYVSGGFD-GSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVAS 425
Query: 408 GLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQ 467
G+IY GG G N +LNS E YDP T WT + PM R G+ + D I+ VGG
Sbjct: 426 GVIYCLGGYDGLN----ILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGF 481
Query: 468 NGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYN 527
+G L +VE Y+I+ + W V+ M V + +Y +AG+ G L I Y+
Sbjct: 482 DGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYD 541
Query: 528 TETDKW 533
D W
Sbjct: 542 PIIDSW 547
Score = 72.4 bits (176), Expect = 1e-12
Identities = 52/185 (28%), Positives = 79/185 (42%), Gaps = 6/185 (3%)
Query: 277 GGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQ-LFPIKRMDCYNV 335
G + S ++P W+ + R A V V+Y LGG L + ++ Y+
Sbjct: 389 GSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLNILNSVEKYDP 448
Query: 336 VKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSML 395
W + T R IY GG + G + L E Y+ RT+SW T SM
Sbjct: 449 HTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFD-GTAHLSSVEAYNIRTDSWTTVTSMT 507
Query: 396 TQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLV 455
T RC G G +Y G GN++ L+S E YDP ++W + M R + G+
Sbjct: 508 TPRCYVGATVLRGRLYAIAGYDGNSL----LSSIECYDPIIDSWEVVTSMGTQRCDAGVC 563
Query: 456 FVKDK 460
+++K
Sbjct: 564 VLREK 568
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 271 bits (693), Expect = 1e-72
Identities = 171/530 (32%), Positives = 269/530 (50%), Gaps = 25/530 (4%)
Query: 21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFA 80
LCD+IL V + KI AH+VVLA+ S +F MFT N+ E ++ EVE + + ++ +VE+A
Sbjct: 34 LCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYA 93
Query: 81 YTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELK 140
YT + ++ + V+SLL AAN QI+ V K C FL+ Q+D NC+GIS AE C +L
Sbjct: 94 YTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGNCIGISRFAETYGCRDLY 153
Query: 141 ATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNR 200
A +I Q+F V +T+EF +L + +++ D L V E+ V+ A W+KYD R
Sbjct: 154 LAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEETVFYALESWIKYDVQER 213
Query: 201 QPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDR--EEL 258
Q ++ +L VR PL+S FL++ +A LI+D+ C ++ ++YH + PE R +
Sbjct: 214 QKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNEALKYHFM-PEHRLSHQT 272
Query: 259 VDGTRPRRKKHDYRIALFGGSQP-----QSCRYFNPKDYSWTDIRCPFEKRRDAACVFWD 313
V TRPR + GG S + P++ SW + R + D
Sbjct: 273 VLMTRPRCAPK--VLCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLD 330
Query: 314 NVVYILGG--SQLFP---IKR----MDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYT 364
VY++GG + + P I++ ++C+N ++W S R +L G++Y
Sbjct: 331 QKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYA 390
Query: 365 SGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGR 424
GG + G S L E Y + W M T R +G+IY GG
Sbjct: 391 LGGYD-GQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGG-----YGPA 444
Query: 425 VLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLN 484
+NS E YDP+ ++W + M + R + G+ + IF VGG NG+ L ++E YD N
Sbjct: 445 HMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPHQN 504
Query: 485 EWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWV 534
+W + PM V A + + +YV+ G G L + +Y+ +D W+
Sbjct: 505 QWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWL 554
Score = 68.2 bits (165), Expect = 2e-11
Identities = 51/178 (28%), Positives = 70/178 (39%), Gaps = 5/178 (2%)
Query: 277 GGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFPIKRMDCYNVV 336
G S QS + PK W + R A D ++Y +GG + ++ Y+
Sbjct: 396 GQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGYGPAHMNSVERYDPS 455
Query: 337 KDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLT 396
KDSW R G I+ GG G S L E YD W M
Sbjct: 456 KDSWEMVASMADKRIHFGVGVMLGFIFVVGGHN-GVSHLSSIERYDPHQNQWTVCRPMKE 514
Query: 397 QRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGL 454
R G + +YV GG G++ LN+ + YDP ++TW + MI R N GL
Sbjct: 515 PRTGVGAAVIDNYLYVVGGHSGSSY----LNTVQKYDPISDTWLDSAGMIYCRCNFGL 568
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 265 bits (677), Expect = 8e-71
Identities = 157/506 (31%), Positives = 261/506 (51%), Gaps = 11/506 (2%)
Query: 55 MLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDF 114
M ES++ V +K+ + + L+++ YTA I V NVQ LL AA Q++ VKK C +F
Sbjct: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
Query: 115 LKEQVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQ 174
L+ Q+ NCLGI A+ C +L A+ + QHF +V ++EFL L +++V L++
Sbjct: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
Query: 175 DTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDN 234
D LT+ +E++V++A + W+ +D+ RQ FM ++ VR PL+ + +L + V+ E L++++
Sbjct: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
Query: 235 PECLKMVISGMRYHLLSPEDREELVDGTRPRRK---KHDYRIALFGGSQPQSCR---YFN 288
C +I M+YHLL P ++ L+ R R + + + GG P++ R ++
Sbjct: 181 SACKDYLIEAMKYHLL-PTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYD 239
Query: 289 PKDYSWTDIRCPFEKRRDAACVFWDNVVYILGG-SQLFPIKRMDCYNVVKDSWYSKLGPP 347
K+ W + +R A V+ +V+ +GG + ++ +D Y+ VKD W S
Sbjct: 240 FKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMR 299
Query: 348 TPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEAN 407
R +L A G +Y GG + G++ L E Y+ ++ W M T+R S G+
Sbjct: 300 DRRSTLGAAVLNGLLYAVGGFD-GSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVG 358
Query: 408 GLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQ 467
GL+Y GG G S + L++ E Y+ T WT + M R G+ + + ++AVGG
Sbjct: 359 GLLYAVGGYDG--ASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGH 416
Query: 468 NGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYN 527
+G +VE YD N W+ V+ M AV ++YV+ G G L + YN
Sbjct: 417 DGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYN 476
Query: 528 TETDKWVANSKVRAFPVTSCLICVVD 553
TDKW S + + + V+D
Sbjct: 477 PTTDKWTVVSSCMSTGRSYAGVTVID 502
Score = 63.5 bits (153), Expect = 5e-10
Identities = 53/195 (27%), Positives = 79/195 (40%), Gaps = 11/195 (5%)
Query: 271 YRIALFGGSQP-QSCRYFNPKDYSWTDIRCPFEKRRDAACV-FWDNVVYILGG---SQLF 325
Y + F GS S +N K W + P RR + V ++Y +GG +
Sbjct: 315 YAVGGFDGSTGLSSVEAYNIKSNEWFHV-APMNTRRSSVGVGVVGGLLYAVGGYDGASRQ 373
Query: 326 PIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRT 385
+ ++CYN + W T R +Y GG + G E YD T
Sbjct: 374 CLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHD-GPLVRKSVEVYDPTT 432
Query: 386 ESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPM 445
+W M R + G+ NGL+YV GG G+ L S E Y+P T+ WT +
Sbjct: 433 NAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCN----LASVEYYNPTTDKWTVVSSC 488
Query: 446 IEARKNHGLVFVKDK 460
+ +++ V V DK
Sbjct: 489 MSTGRSYAGVTVIDK 503
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 265 bits (676), Expect = 1e-70
Identities = 159/530 (30%), Positives = 265/530 (50%), Gaps = 61/530 (11%)
Query: 19 KTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVE 78
K LCDVIL+ +R+IPAHR+VL++ S +F MFT ++ E++ E++++ EP+ + L++
Sbjct: 171 KQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQ 230
Query: 79 FAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPE 138
+AYT R+ + +N++ LL A Q+ V + C FL +Q+ SNCLGI A+ C +
Sbjct: 231 YAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTD 290
Query: 139 LKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEP 198
L A ++ +HF EV + EF+ L + LL D + + E+ + +A + W+++D
Sbjct: 291 LHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLE 350
Query: 199 NRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREEL 258
R+ + +LA +R PL++ FL+ ++ L +D+ EC K+++ M+YHLL PE R L
Sbjct: 351 QRRKDLSKLLAYIRLPLLAPQFLA-DMENNVLFRDDIECQKLIMEAMKYHLL-PERRPML 408
Query: 259 VD-GTRPRRKKHDYRIALFGGSQPQ---SCRYFNPKDYSWTDIRCPFEKRRDAACVFWDN 314
T+PR+ A+ G + S ++ + WT + +R D+
Sbjct: 409 QSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDD 468
Query: 315 VVYILGGSQ-LFPIKRMDCYNVVKDSWYSKLGPP-------------------------- 347
+Y++GG L + ++CYN +W + PP
Sbjct: 469 KLYVVGGRDGLKTLNTVECYNPKTKTW--SVMPPMSTHRHGLGVAVLEGPMYAVGGHDGW 526
Query: 348 -----------------------TPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTR 384
TPR ++ GK+Y GG + G+S L EC+D
Sbjct: 527 SYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRD-GSSCLKSVECFDPH 585
Query: 385 TESWHTKPSMLTQRCSHGMVEANGLIYVCGG--SLGNNVSGRVLNSCEVYDPATETWTEL 442
T W M +R G+ NGL+Y GG + +N++ R+ + E YDP T+ WT +
Sbjct: 586 TNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAV 645
Query: 443 CPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPM 492
M +R G+ + DK++AVGG +G L+ VE YD + NEW V+P+
Sbjct: 646 ASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPL 695
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 265 bits (676), Expect = 1e-70
Identities = 159/530 (30%), Positives = 265/530 (50%), Gaps = 61/530 (11%)
Query: 19 KTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVE 78
K LCDVIL+ +R+IPAHR+VL++ S +F MFT ++ E++ E++++ EP+ + L++
Sbjct: 217 KQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQ 276
Query: 79 FAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPE 138
+AYT R+ + +N++ LL A Q+ V + C FL +Q+ SNCLGI A+ C +
Sbjct: 277 YAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTD 336
Query: 139 LKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEP 198
L A ++ +HF EV + EF+ L + LL D + + E+ + +A + W+++D
Sbjct: 337 LHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLE 396
Query: 199 NRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREEL 258
R+ + +LA +R PL++ FL+ ++ L +D+ EC K+++ M+YHLL PE R L
Sbjct: 397 QRRKDLSKLLAYIRLPLLAPQFLA-DMENNVLFRDDIECQKLIMEAMKYHLL-PERRPML 454
Query: 259 VD-GTRPRRKKHDYRIALFGGSQPQ---SCRYFNPKDYSWTDIRCPFEKRRDAACVFWDN 314
T+PR+ A+ G + S ++ + WT + +R D+
Sbjct: 455 QSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDD 514
Query: 315 VVYILGGSQ-LFPIKRMDCYNVVKDSWYSKLGPP-------------------------- 347
+Y++GG L + ++CYN +W + PP
Sbjct: 515 KLYVVGGRDGLKTLNTVECYNPKTKTW--SVMPPMSTHRHGLGVAVLEGPMYAVGGHDGW 572
Query: 348 -----------------------TPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTR 384
TPR ++ GK+Y GG + G+S L EC+D
Sbjct: 573 SYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRD-GSSCLKSVECFDPH 631
Query: 385 TESWHTKPSMLTQRCSHGMVEANGLIYVCGG--SLGNNVSGRVLNSCEVYDPATETWTEL 442
T W M +R G+ NGL+Y GG + +N++ R+ + E YDP T+ WT +
Sbjct: 632 TNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAV 691
Query: 443 CPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPM 492
M +R G+ + DK++AVGG +G L+ VE YD + NEW V+P+
Sbjct: 692 ASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPL 741
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 261 bits (666), Expect = 2e-69
Identities = 170/539 (31%), Positives = 266/539 (49%), Gaps = 29/539 (5%)
Query: 11 LTSHINLKKTLCDVILMVQERKIPA-----HRVVLAAASHFFNLMFTTNMLESKSFEVEL 65
+ + + L + LCDV L V+ + PA H+VVLA++S F MFT + E V +
Sbjct: 66 IMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSI 125
Query: 66 KDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCL 125
+ P ++E+L+EFAYTA IS+ V +++ A YQI+ V + C DFL +Q+D SN +
Sbjct: 126 EGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAI 185
Query: 126 GISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQV 185
GI+ AE + C EL A ++I+ HF EV K +EF L ++ L+++D L VR E +V
Sbjct: 186 GIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEV 245
Query: 186 YDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGM 245
+ A + W+KYD R+ ++ +L VR ++ NFL +Q ++Q + C ++
Sbjct: 246 FHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVK-- 303
Query: 246 RYHLLSPEDREELVDGTRPRRKKHDYRIALFGGSQPQSCRY---FNPKDYSW---TDIRC 299
+ L+ +++ P+ + Y GG QS Y +NP D +W D++
Sbjct: 304 IFEELTLHKPTQVMPCRAPKVGRLIYTA---GGYFRQSLSYLEAYNPSDGTWLRLADLQV 360
Query: 300 PFEKRRDAACVFWDNVVYILGGSQLFP-----IKRMDCYNVVKDSWYSKLGPPTPRDSLA 354
P + A CV ++Y +GG P +DCYN + + W PR+ +
Sbjct: 361 P--RSGLAGCVV-GGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIG 417
Query: 355 ACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCG 414
+G IY GGS G E Y+ + WH MLT+R G+ N L+Y G
Sbjct: 418 VGVIDGHIYAVGGSH-GCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVG 476
Query: 415 GSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLD 474
G G N LNS E Y P W + M R G+ + + I+A GG +G L+
Sbjct: 477 GFDGTN----RLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLN 532
Query: 475 NVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 533
+VE YD++ W V+PM + + +YVL G+ G L + Y+ +TD W
Sbjct: 533 SVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTW 591
Score = 71.6 bits (174), Expect = 2e-12
Identities = 53/190 (27%), Positives = 77/190 (40%), Gaps = 10/190 (5%)
Query: 270 DYRIALFGGSQP----QSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQ-L 324
D I GGS S + P+ W + +R + ++Y +GG
Sbjct: 422 DGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGT 481
Query: 325 FPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTR 384
+ +CY ++ W T R C IY +GG + G L E YD
Sbjct: 482 NRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYD-GQDQLNSVERYDVE 540
Query: 385 TESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCP 444
TE+W M +R + G+ G IYV GG G+ L+S E YDP T+TW+E+
Sbjct: 541 TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTF----LDSVECYDPDTDTWSEVTR 596
Query: 445 MIEARKNHGL 454
M R G+
Sbjct: 597 MTSGRSGVGV 606
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 261 bits (666), Expect = 2e-69
Identities = 170/539 (31%), Positives = 266/539 (49%), Gaps = 29/539 (5%)
Query: 11 LTSHINLKKTLCDVILMVQERKIPA-----HRVVLAAASHFFNLMFTTNMLESKSFEVEL 65
+ + + L + LCDV L V+ + PA H+VVLA++S F MFT + E V +
Sbjct: 66 IMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSI 125
Query: 66 KDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCL 125
+ P ++E+L+EFAYTA IS+ V +++ A YQI+ V + C DFL +Q+D SN +
Sbjct: 126 EGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAI 185
Query: 126 GISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQV 185
GI+ AE + C EL A ++I+ HF EV K +EF L ++ L+++D L VR E +V
Sbjct: 186 GIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEV 245
Query: 186 YDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGM 245
+ A + W+KYD R+ ++ +L VR ++ NFL +Q ++Q + C ++
Sbjct: 246 FHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVK-- 303
Query: 246 RYHLLSPEDREELVDGTRPRRKKHDYRIALFGGSQPQSCRY---FNPKDYSW---TDIRC 299
+ L+ +++ P+ + Y GG QS Y +NP D +W D++
Sbjct: 304 IFEELTLHKPTQVMPCRAPKVGRLIYTA---GGYFRQSLSYLEAYNPSDGTWLRLADLQV 360
Query: 300 PFEKRRDAACVFWDNVVYILGGSQLFP-----IKRMDCYNVVKDSWYSKLGPPTPRDSLA 354
P + A CV ++Y +GG P +DCYN + + W PR+ +
Sbjct: 361 P--RSGLAGCVV-GGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIG 417
Query: 355 ACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCG 414
+G IY GGS G E Y+ + WH MLT+R G+ N L+Y G
Sbjct: 418 VGVIDGHIYAVGGSH-GCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVG 476
Query: 415 GSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLD 474
G G N LNS E Y P W + M R G+ + + I+A GG +G L+
Sbjct: 477 GFDGTN----RLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLN 532
Query: 475 NVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 533
+VE YD++ W V+PM + + +YVL G+ G L + Y+ +TD W
Sbjct: 533 SVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTW 591
Score = 71.6 bits (174), Expect = 2e-12
Identities = 53/190 (27%), Positives = 77/190 (40%), Gaps = 10/190 (5%)
Query: 270 DYRIALFGGSQP----QSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQ-L 324
D I GGS S + P+ W + +R + ++Y +GG
Sbjct: 422 DGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGT 481
Query: 325 FPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTR 384
+ +CY ++ W T R C IY +GG + G L E YD
Sbjct: 482 NRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYD-GQDQLNSVERYDVE 540
Query: 385 TESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCP 444
TE+W M +R + G+ G IYV GG G+ L+S E YDP T+TW+E+
Sbjct: 541 TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTF----LDSVECYDPDTDTWSEVTR 596
Query: 445 MIEARKNHGL 454
M R G+
Sbjct: 597 MTSGRSGVGV 606
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 260 bits (664), Expect = 3e-69
Identities = 165/545 (30%), Positives = 264/545 (48%), Gaps = 18/545 (3%)
Query: 18 KKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLV 77
+K LCDV+L+ +IPAHR+VL+A S +F MFT ++LE+K EV ++ +P+ + LV
Sbjct: 178 EKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLV 237
Query: 78 EFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCP 137
++AYT + + + ++SLL AA Q+ V +C +FL +Q+ SNCLGI + C
Sbjct: 238 QYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCT 297
Query: 138 ELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDE 197
EL A + +HF EV K EFL L ++ LL D + V E+ ++ A ++W+ +D
Sbjct: 298 ELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDV 357
Query: 198 PNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREE 257
NRQ + +L+ +R PL+ L+ ++ + + EC K+++ M+YHLL PE R
Sbjct: 358 QNRQGELGMLLSYIRLPLLPPQLLA-DLETSSMFTGDLECQKLLMEAMKYHLL-PERRSM 415
Query: 258 LVDGTRPRRKKHDYRIALFGGSQPQ----SCRYFNPKDYSWTDIRCPFEKRRDAACVFWD 313
+ RK + GG + ++ + SW I +R D
Sbjct: 416 MQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVID 475
Query: 314 NVVYILGGSQ-LFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGN 372
N +Y++GG L + ++C+N V W T R L EG +Y GG + G
Sbjct: 476 NKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHD-GW 534
Query: 373 SALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVY 432
S L E +D W+ SM T R + G+V N +Y GG G++ L S E +
Sbjct: 535 SYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSS----CLKSMEYF 590
Query: 433 DPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGG------LDNVEYYDIKLNEW 486
DP T W+ PM + R G+ ++ VGG + D VE YD K + W
Sbjct: 591 DPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSW 650
Query: 487 KMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVRAFPVTS 546
V+P+ V +G +YV+ G+ G L + Y+ + ++W V +
Sbjct: 651 STVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAGA 710
Query: 547 CLICV 551
C++ V
Sbjct: 711 CVVVV 715
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 259 bits (662), Expect = 5e-69
Identities = 164/545 (30%), Positives = 271/545 (49%), Gaps = 18/545 (3%)
Query: 18 KKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLV 77
++ LCDVIL+V RKIPAHR+VL++ S +F MFT+++ E+K E++++ +P+ + LV
Sbjct: 208 QQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLV 267
Query: 78 EFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCP 137
+FAYT + + + +++LL AA Q+ V ++C FL + + SNCLGI A+ C
Sbjct: 268 QFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCI 327
Query: 138 ELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDE 197
EL A + ++ EV + EFL L + + LL D + V E+ ++ A + W+KYD
Sbjct: 328 ELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDM 387
Query: 198 PNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREE 257
+R + +LA +R PL+ L+ ++ L +++ EC K+++ M+YHLL PE R
Sbjct: 388 QSRCNDLSMLLAFIRLPLLPPQILA-DLENHALFKNDLECQKLILEAMKYHLL-PERRTL 445
Query: 258 LVD-GTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYS---WTDIRCPFEKRRDAACVFWD 313
+ T+PR+ A+ G + D W +R D
Sbjct: 446 MQSPRTKPRKSTVGTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVID 505
Query: 314 NVVYILGGSQ-LFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGN 372
+ ++++GG L + ++CYN +W T R L EG IY GG + G
Sbjct: 506 DKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHD-GW 564
Query: 373 SALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVY 432
S L E +D +++ W SM R + G+ NG +Y GG G++ L+S E Y
Sbjct: 565 SYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSS----CLSSMEYY 620
Query: 433 DPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGG------LDNVEYYDIKLNEW 486
DP T W PM + R G+ ++AVGG + LD VE YD K + W
Sbjct: 621 DPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTW 680
Query: 487 KMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVRAFPVTS 546
MV+P+ V +G +Y + G+ G L + Y+ +T++W + + +
Sbjct: 681 TMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASLNIGRAGA 740
Query: 547 CLICV 551
C++ +
Sbjct: 741 CVVVI 745
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 257 bits (657), Expect = 2e-68
Identities = 162/527 (30%), Positives = 258/527 (48%), Gaps = 18/527 (3%)
Query: 18 KKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLV 77
+K LCDV+L+ +IPAHR+VL+A S +F MFT ++LE+K EV ++ +P+ + LV
Sbjct: 178 EKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLV 237
Query: 78 EFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCP 137
++AYT + + + ++SLL AA Q+ V +C +FL +Q+ SNCLGI + C
Sbjct: 238 QYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCT 297
Query: 138 ELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDE 197
EL A + +HF EV K EFL L ++ LL D + V E+ ++ A ++W+ +D
Sbjct: 298 ELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDV 357
Query: 198 PNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREE 257
NRQ + +L+ +R PL+ L+ ++ + + EC K+++ M+YHLL PE R
Sbjct: 358 QNRQGELGMLLSYIRLPLLPPQLLA-DLETSSMFTGDLECQKLLMEAMKYHLL-PERRSM 415
Query: 258 LVDGTRPRRKKHDYRIALFGGSQPQ----SCRYFNPKDYSWTDIRCPFEKRRDAACVFWD 313
+ RK + GG + ++ + SW I +R D
Sbjct: 416 MQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVID 475
Query: 314 NVVYILGGSQ-LFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGN 372
N +Y++GG L + ++C+N V W T R L EG +Y GG + G
Sbjct: 476 NKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHD-GW 534
Query: 373 SALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVY 432
S L E +D W+ SM T R + G+V N +Y GG G++ L S E +
Sbjct: 535 SYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSS----CLKSMEYF 590
Query: 433 DPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGG------LDNVEYYDIKLNEW 486
DP T W+ PM + R G+ ++ VGG + D VE YD K + W
Sbjct: 591 DPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSW 650
Query: 487 KMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 533
V+P+ V +G +YV+ G+ G L + Y+ + ++W
Sbjct: 651 STVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEW 697
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 241 bits (616), Expect = 1e-63
Identities = 152/514 (29%), Positives = 245/514 (47%), Gaps = 46/514 (8%)
Query: 21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFA 80
LCDV L V + I H++VLA +F MF + M E+K +E++D + D IE LV+F
Sbjct: 66 LCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFV 125
Query: 81 YTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELK 140
Y++R+++ +NVQ LL AA Q+E V + C +++K SNCL + AE + +L
Sbjct: 126 YSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNRIDLM 185
Query: 141 ATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNR 200
AD + HFTEV + ++F+ + + + LL+ L + E QVY+AA++WL + +
Sbjct: 186 DMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHH 245
Query: 201 QPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHL-LSPEDREELV 259
++ + LA+VR PL+ +FL V E +++ N +C ++ YHL LS +
Sbjct: 246 SKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSRAVPDFE 305
Query: 260 DGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYIL 319
R +KH + G +
Sbjct: 306 YSIRTTPRKHTAGVLFCVGGR--------------------------------------- 326
Query: 320 GGSQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFE 379
GGS P + ++CY++ K+SW+ + R + + EGK+Y GG + GN L E
Sbjct: 327 GGSG-DPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHD-GNEHLGSME 384
Query: 380 CYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETW 439
+D T W K SM T+R + G IY GG N N E YD ++ W
Sbjct: 385 MFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNT----CFNDVERYDIESDQW 440
Query: 440 TELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTV 499
+ + PM R G V + + ++AVGG +G+ L +VE YD L++W V M +
Sbjct: 441 STVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGN 500
Query: 500 KCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 533
+ + +YV+ GF L + Y+ ++KW
Sbjct: 501 GVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKW 534
Score = 91.7 bits (226), Expect = 2e-18
Identities = 56/187 (29%), Positives = 83/187 (44%), Gaps = 9/187 (4%)
Query: 348 TPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEAN 407
TPR A G ++ GG ECY SW P M ++R G++
Sbjct: 311 TPRKHTA-----GVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVE 365
Query: 408 GLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQ 467
G +Y GG GN G S E++DP T W M R+ L + I+A+GG
Sbjct: 366 GKVYAVGGHDGNEHLG----SMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGL 421
Query: 468 NGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYN 527
+ ++VE YDI+ ++W V+PM V A+ + VY + G G+ L + Y+
Sbjct: 422 DDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYD 481
Query: 528 TETDKWV 534
DKW+
Sbjct: 482 PHLDKWI 488
Score = 52.8 bits (125), Expect = 8e-07
Identities = 48/188 (25%), Positives = 70/188 (37%), Gaps = 12/188 (6%)
Query: 273 IALFGGSQPQSC-----RYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQ-LFP 326
I GG +C RY D W+ + R V N VY +GG+ +
Sbjct: 415 IYAIGGLDDNTCFNDVERYDIESD-QWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMAS 473
Query: 327 IKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTE 386
+ ++ Y+ D W R G +Y GG + NS L E YD R+
Sbjct: 474 LSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFD-DNSPLSSVERYDPRSN 532
Query: 387 SWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMI 446
W ++ T R G+ G I+ GG GN LN+ E +DP W + +
Sbjct: 533 KWDYVAALTTPRGGVGIATVMGKIFAVGGHNGN----AYLNTVEAFDPVLNRWELVGSVS 588
Query: 447 EARKNHGL 454
R G+
Sbjct: 589 HCRAGAGV 596
Score = 38.5 bits (88), Expect = 0.017
Identities = 27/91 (29%), Positives = 41/91 (45%), Gaps = 5/91 (5%)
Query: 461 IFAVGGQNGLGG-LDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGR 519
+F VGG+ G G ++E Y I N W M + V +V VY + G G
Sbjct: 320 LFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEH 379
Query: 520 LGHILEYNTETDKWV----ANSKVRAFPVTS 546
LG + ++ T+KW+ N+K R + S
Sbjct: 380 LGSMEMFDPLTNKWMMKASMNTKRRGIALAS 410
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 241 bits (614), Expect = 2e-63
Identities = 168/550 (30%), Positives = 257/550 (46%), Gaps = 58/550 (10%)
Query: 22 CDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAY 81
CDV L V + AHR+VLAA+S +F +FT M ES V + E I + L++F Y
Sbjct: 37 CDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVVPILGIEAGIFQILLDFIY 96
Query: 82 TARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELKA 141
T +++ NNVQ L+ AA+ Q+ V +C +FLK Q+D NC+GI +E + C +L
Sbjct: 97 TGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLE 156
Query: 142 TADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQ 201
++++IH HF EV+ +EFL L ++ +L + L++ E QV+ AA++W+ D R+
Sbjct: 157 FSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQWILKDLGKRR 216
Query: 202 PFMVDILAKVRFPLISKNFLSKTVQA----------EPLIQDNPECLKMVISGMRYHLLS 251
+V++L +RFPL+ L K ++ + L+++ E K S
Sbjct: 217 KHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKEYCEVCK-----------S 265
Query: 252 PEDREEL----VDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYS-----------WTD 296
P++ + RPR+K Y A+ G ++ Q R+ + + S WT
Sbjct: 266 PKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTT 325
Query: 297 IRCPFEKRRDAACVFWDNVVYILGG---SQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSL 353
+ + R +VY +GG S +F +CY+ V W + PR L
Sbjct: 326 VSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDC--TECYDPVTKQWTTVASMNHPRCGL 383
Query: 354 AACAAEGKIYTSG---GSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLI 410
C G IY G G+E+GN+ E +D W +M R G E GLI
Sbjct: 384 GVCVCYGAIYALGGWVGAEIGNT----IERFDPDENKWEVVGNMAVSRYYFGCCEMQGLI 439
Query: 411 YVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGL 470
YV GG + L S EVYDP ++ W+ L PM R G+ + D I++VGG N
Sbjct: 440 YVIGGISNEGIE---LRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNET 496
Query: 471 -GGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAG------FQGVGRLGHI 523
L VE Y + +W V+ M + AV ++YV G F G L +
Sbjct: 497 QDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSV 556
Query: 524 LEYNTETDKW 533
YN +D W
Sbjct: 557 EVYNPHSDTW 566
Score = 75.5 bits (184), Expect = 1e-13
Identities = 49/172 (28%), Positives = 78/172 (45%), Gaps = 4/172 (2%)
Query: 287 FNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGG--SQLFPIKRMDCYNVVKDSWYSKL 344
F+P + W + R C ++Y++GG ++ ++ + Y+ + W
Sbjct: 410 FDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLP 469
Query: 345 GPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMV 404
T R L A IY+ GG AL+ E Y E W SM R +V
Sbjct: 470 PMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVV 529
Query: 405 EANGLIYVCGGSLGNN--VSGRVLNSCEVYDPATETWTELCPMIEARKNHGL 454
NGL+YV GG ++ ++ L+S EVY+P ++TWTE+ MI +R G+
Sbjct: 530 AVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGV 581
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 239 bits (610), Expect = 5e-63
Identities = 147/512 (28%), Positives = 250/512 (48%), Gaps = 61/512 (11%)
Query: 37 RVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLL 96
R+VL++ S +F MFT ++ E++ E++++ EP+ + L+++AYT R+ + +N++ LL
Sbjct: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
Query: 97 DAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYK 156
A Q+ V + C FL +Q+ SNCLGI A+ C +L A ++ +HF EV +
Sbjct: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
Query: 157 TDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLI 216
EF+ L + LL D + + E+ + +A + W+++D R+ + +LA +R PL+
Sbjct: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353
Query: 217 SKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREELVD-GTRPRRKKHDYRIAL 275
+ FL+ ++ L +D+ EC K+++ M+YHLL PE R L T+PR+ A+
Sbjct: 354 APQFLA-DMENNVLFRDDIECQKLIMEAMKYHLL-PERRPMLQSPRTKPRKSTVGTLFAV 411
Query: 276 FGGSQPQ---SCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQ-LFPIKRMD 331
G + S ++ + WT + +R D+ +Y++GG L + ++
Sbjct: 412 GGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVE 471
Query: 332 CYNVVKDSWYSKLGPP-------------------------------------------- 347
CYN +W + PP
Sbjct: 472 CYNPKTKTW--SVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNF 529
Query: 348 -----TPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHG 402
TPR ++ GK+Y GG + G+S L EC+D T W M +R G
Sbjct: 530 VATMSTPRSTVGVAVLSGKLYAVGGRD-GSSCLKSVECFDPHTNKWTLCAQMSKRRGGVG 588
Query: 403 MVEANGLIYVCGG--SLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDK 460
+ NGL+Y GG + +N++ R+ + E YDP T+ WT + M +R G+ + DK
Sbjct: 589 VTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDK 648
Query: 461 IFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPM 492
++AVGG +G L+ VE YD + NEW V+P+
Sbjct: 649 LYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPL 680
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 233 bits (595), Expect = 3e-61
Identities = 156/569 (27%), Positives = 265/569 (46%), Gaps = 30/569 (5%)
Query: 7 CRTFLTSHINLKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELK 66
C F + + L+ LCDV++ V + AH+ +L + S +F +FT+ ++ +
Sbjct: 26 CEIF--NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIP 83
Query: 67 DAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLG 126
PD+++ ++E+AYT + + +NV+ LL AA+Q+ I + + C +FLK ++ NC+G
Sbjct: 84 GISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIG 143
Query: 127 ISVLAECLDCPELKATADDFIHQHFTEVYKTD-EFLQLDVKRVTHLLNQDTLTVRAEDQV 185
I + CPEL+ A FI +F E+ K EFL+L V + ++ +D L V+ ED V
Sbjct: 144 ICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAV 203
Query: 186 YDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGM 245
++A ++W+ +D NR+ + +L KVR L+ + V+ ++D+ EC ++I+ +
Sbjct: 204 FEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINAL 263
Query: 246 R----YHLLSPEDREELVDGTRPRRKKHDYRIAL-----FGGSQPQSCRYFNPKDYSWTD 296
+ ++ P + + TRPR Y I GGS + ++ + W +
Sbjct: 264 KAMYDLNMNGPSNSDFTNPLTRPRL---PYAILFAIGGWSGGSPTNAIEAYDARADRWVN 320
Query: 297 IRCPFEK-RRDAACVFWDNVVYILGG----SQLFPIKRMDCYNVVKDSWYSKLGPPTPRD 351
+ C E R + VYI+GG +KR D VK +W+ + R
Sbjct: 321 VTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFD---PVKKTWHQVAPMHSRRC 377
Query: 352 SLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIY 411
++ IY GG + G L E Y+ T W M QR G +Y
Sbjct: 378 YVSVTVLGNFIYAMGGFD-GYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVY 436
Query: 412 VCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLG 471
+CGG GN L + EVY+ + WT + PM R G++ + ++AVGG +G
Sbjct: 437 ICGGFNGN----ECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGAN 492
Query: 472 GLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETD 531
L + E Y N W+ + M V +++V+ GF G ++ Y+ +TD
Sbjct: 493 RLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTD 552
Query: 532 KWVANSKVRAFPVTSCLICVVDTCGANEE 560
+W + + S L C V AN E
Sbjct: 553 EWYDAHDMSIY--RSALSCCVVPGLANVE 579
>gi|223890235 intracisternal A particle-promoted polypeptide isoform
2 [Homo sapiens]
Length = 582
Score = 233 bits (595), Expect = 3e-61
Identities = 161/524 (30%), Positives = 248/524 (47%), Gaps = 52/524 (9%)
Query: 22 CDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAY 81
CDV L V + AHR+VLAA+S +F +FT M ES V + E I + L++F Y
Sbjct: 37 CDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVVPILGIEAGIFQILLDFIY 96
Query: 82 TARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELKA 141
T +++ NNVQ L+ AA+ Q+ V +C +FLK Q+D NC+GI +E + C +L
Sbjct: 97 TGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLE 156
Query: 142 TADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQ 201
++++IH HF EV+ +EFL L ++ +L + L++ E QV+ AA++W+ D R+
Sbjct: 157 FSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQWILKDLGKRR 216
Query: 202 PFMVDILAKVRFPLISKNFLSKTVQA----------EPLIQDNPECLKMVISGMRYHLLS 251
+V++L +RFPL+ L K ++ + L+++ E K S
Sbjct: 217 KHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKEYCEVCK-----------S 265
Query: 252 PEDREEL----VDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYS-----------WTD 296
P++ + RPR+K Y A+ G ++ Q R+ + + S WT
Sbjct: 266 PKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTT 325
Query: 297 IRCPFEKRRDAACVFWDNVVYILGG---SQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSL 353
+ + R +VY +GG S +F +CY+ V W + PR L
Sbjct: 326 VSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDC--TECYDPVTKQWTTVASMNHPRCGL 383
Query: 354 AACAAEGKIYTSG---GSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLI 410
C G IY G G+E+GN+ E +D W +M R G E GLI
Sbjct: 384 GVCVCYGAIYALGGWVGAEIGNT----IERFDPDENKWEVVGNMAVSRYYFGCCEMQGLI 439
Query: 411 YVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGL 470
YV GG + L S EVYDP ++ W+ L PM R G+ + D I++VGG N
Sbjct: 440 YVIGGISNEGIE---LRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNET 496
Query: 471 -GGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAG 513
L VE Y + +W V+ M + AV ++YV G
Sbjct: 497 QDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG 540
Score = 71.2 bits (173), Expect = 2e-12
Identities = 47/178 (26%), Positives = 76/178 (42%), Gaps = 5/178 (2%)
Query: 357 AAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGS 416
A G GG + AL E +DT ++ W T S+ R G+ G++Y GG
Sbjct: 292 AVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGE 351
Query: 417 LGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNV 476
+ + + E YDP T+ WT + M R G+ I+A+GG G + +
Sbjct: 352 KDS----MIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTI 407
Query: 477 EYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVG-RLGHILEYNTETDKW 533
E +D N+W++V M C + ++YV+ G G L Y+ + +W
Sbjct: 408 ERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRW 465
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 215 bits (547), Expect = 1e-55
Identities = 139/497 (27%), Positives = 234/497 (47%), Gaps = 60/497 (12%)
Query: 23 DVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYT 82
DVI+ V+ ++ P HR VL+A S +F MF + ES+ VE+ + +E +++ YT
Sbjct: 67 DVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAMECFLQYVYT 126
Query: 83 ARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELKAT 142
++ + + NVQ L + ++ +QI ++ C FL+EQ+D NCLGI A+ L
Sbjct: 127 GKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFTK 186
Query: 143 ADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQP 202
+F Q F +V + +EFL+LD + + D L + E+ V++A +RW+ R+P
Sbjct: 187 CKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRP 246
Query: 203 FMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREELVDGT 262
+ ++L VR PL+ N+ +TV+ + LIQ++PEC +++ RYH+L E + T
Sbjct: 247 LLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHILG---NEMMSPRT 303
Query: 263 RPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGS 322
RPRR + V+ ++GG
Sbjct: 304 RPRRS------------------------------------------TGYSEVIVVVGGC 321
Query: 323 QL---FPIKRMDCYNVVKDSWYS--KLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYL 377
+ F + +CY+ V W S KL P + A CA I SGG + + +++
Sbjct: 322 ERVGGFNLPYTECYDPVTGEWKSLAKL-PEFTKSEYAVCALRNDILVSGG-RINSRDVWI 379
Query: 378 FECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATE 437
Y+++ W S+ R H M G +YV GG G N L+S E YD +
Sbjct: 380 ---YNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQN----RLSSVECYDSFSN 432
Query: 438 TWTELCPMIEARKNHGLVFVKDKIFAV-GGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKG 496
WTE+ P+ EA + + K+F + GG + D V+ YD + N W + + +P
Sbjct: 433 RWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAK 492
Query: 497 VTVKCAAVGSIVYVLAG 513
+ ++ +++YV G
Sbjct: 493 RCITAVSLNNLIYVAGG 509
Score = 57.8 bits (138), Expect = 3e-08
Identities = 51/229 (22%), Positives = 88/229 (38%), Gaps = 17/229 (7%)
Query: 331 DCYNVVKDSW-YSKLG----PPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRT 385
+CY ++ ++ Y LG P R + +E + G VG L ECYD T
Sbjct: 280 ECYQLLHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVT 339
Query: 386 ESWHTKPSMLT-QRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCP 444
W + + + + + I V GG + + +Y+ W +
Sbjct: 340 GEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINSR-------DVWIYNSQLNIWIRVAS 392
Query: 445 MIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWK-GVTVKCAA 503
+ + R H + + K++ VGG +G L +VE YD N W V+P+ +
Sbjct: 393 LNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSC 452
Query: 504 VGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVRAFPVTSCLICVV 552
VG + + G + Y+ ET+ W+ + A P+ I V
Sbjct: 453 VGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRA---AIPIAKRCITAV 498
Score = 52.0 bits (123), Expect = 1e-06
Identities = 43/183 (23%), Positives = 74/183 (40%), Gaps = 11/183 (6%)
Query: 277 GGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGS--QLFPIKRMDCYN 334
G ++ S ++ WT++ E A ++++GG ++ Y+
Sbjct: 417 GQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYD 476
Query: 335 VVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSM 394
+SW + P + + A + IY +GG A+Y CYD + W +
Sbjct: 477 PETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGL---TKAIY---CYDPVEDYWMHVQNT 530
Query: 395 LTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGL 454
+++ + GM NG IY+ GG N G ++ YDPAT T + M HG
Sbjct: 531 FSRQENCGMSVCNGKIYILGGRREN---GEATDTILCYDPATSIITGVAAMPRPVSYHGC 587
Query: 455 VFV 457
V +
Sbjct: 588 VTI 590
>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
sapiens]
Length = 589
Score = 206 bits (525), Expect = 4e-53
Identities = 148/542 (27%), Positives = 239/542 (44%), Gaps = 62/542 (11%)
Query: 13 SHINL---KKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDA- 68
+H+NL ++ DV+L R P HR VLAA S +F MF+ + ES+ EV ++
Sbjct: 34 THLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFDNSI 93
Query: 69 EPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGIS 128
P+++E L+++AY++R+ +N N +SLL+A + + + ++ C +FL++ + +NCLG+
Sbjct: 94 HPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGML 153
Query: 129 VLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDA 188
+L++ C +L + +F + K ++FLQL V LL+ + L E VY++
Sbjct: 154 LLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLVYES 213
Query: 189 AVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYH 248
A+ W+ YD R ++ ++L VR L+ +L + V E LI + ++V +R
Sbjct: 214 AINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVEEAIRCK 273
Query: 249 L-LSPEDREELVDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFEKRRDA 307
L + D RPR+ H
Sbjct: 274 LKILQNDGVVTSLCARPRKTGH-------------------------------------- 295
Query: 308 ACVFWDNVVYILGGSQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGG 367
+++LGG Q F ++ + K P+PR +ACA K+Y +GG
Sbjct: 296 -------ALFLLGG-QTFMCDKLYLVDQKAKEIIPKADIPSPRKEFSACAIGCKVYITGG 347
Query: 368 SEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNN----VSG 423
N YDT E W ML R HG E +YV GG S
Sbjct: 348 RGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAATGCLPASP 407
Query: 424 RV-LNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQN-GLGGLDNVEYYDI 481
V L E YDP WT + P+ E N +V K K+FA GG + L V+ YD
Sbjct: 408 SVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQ 467
Query: 482 KLNEWKM--VSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKV 539
N W + P PW+ A +G+ ++++ G ++N+ET +W V
Sbjct: 468 CENRWTVPATCPQPWR--YTAAAVLGNQIFIMGGDTEFSACS-AYKFNSETYQWTKVGDV 524
Query: 540 RA 541
A
Sbjct: 525 TA 526
>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 875
Score = 206 bits (524), Expect = 5e-53
Identities = 142/465 (30%), Positives = 226/465 (48%), Gaps = 22/465 (4%)
Query: 19 KTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLES-----KSFEVELKDAEPDII 73
K D+ ++V+ R+ H+ VLA+ S +F + ++ +S + E+ L + + D++
Sbjct: 326 KAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLSNLQADVL 385
Query: 74 EQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAEC 133
E L+EF YT + ++S N ++LL+AA+++Q K+CV FL++Q+ ASNCLG+ +AE
Sbjct: 386 ELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGVLAMAEA 445
Query: 134 LDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWL 193
+ C EL A F Q F EV +E L + ++ D+L +AE+ VY+ ++W+
Sbjct: 446 MQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWI 505
Query: 194 KYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPE 253
K D R + ++LA VR P I ++L V E LI+ + C +V RYH+L
Sbjct: 506 KKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHMLPHA 565
Query: 254 DREELVDGTRPRRKKHDYR-IALFGGSQP--------QSCRYFNPKDYSWTDI-RCPFEK 303
+E TRPR I L GG Q + +NP++ W + PF
Sbjct: 566 RQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYD 625
Query: 304 RRDAACVFWDNVVYILGGSQL-FPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKI 362
R + V + +Y+ GG + + + CY + D+W PR + +GKI
Sbjct: 626 REFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKI 685
Query: 363 YTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVS 422
YT GG V + ++ E YDT T W + S G IYV GG N +
Sbjct: 686 YTLGGLGVAGNVDHV-ERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGV---NEA 741
Query: 423 GRVLNSCEVYDPATETWTEL-CPMIEARKNHGLVFVKDKIFAVGG 466
GR + Y P T TW+ + PMI+ K V + +F +GG
Sbjct: 742 GRAAGVLQSYVPQTNTWSFIESPMID-NKYAPAVTLNGFVFILGG 785
Score = 74.3 bits (181), Expect = 3e-13
Identities = 53/191 (27%), Positives = 81/191 (42%), Gaps = 8/191 (4%)
Query: 347 PTPRDSLAACAAEGKIYTSGGSEVGNS--ALYLFECYDTRTESWHTKPSM-LTQRCSHGM 403
P R L+A AE + G VG + +L C++ + W+ S+ R +
Sbjct: 572 PRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSV 631
Query: 404 VEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFA 463
V A IY+ GG SG L Y + W + M R H + KI+
Sbjct: 632 VSAGDNIYLSGGM----ESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYT 687
Query: 464 VGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHI 523
+GG G +D+VE YD N+W+ V+P+P + G +YV G GR +
Sbjct: 688 LGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGV 747
Query: 524 LE-YNTETDKW 533
L+ Y +T+ W
Sbjct: 748 LQSYVPQTNTW 758
Score = 45.4 bits (106), Expect = 1e-04
Identities = 39/152 (25%), Positives = 61/152 (40%), Gaps = 8/152 (5%)
Query: 389 HTKPSMLTQRC----SHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCP 444
H + M T R S G+ E +I + GG ++ R L + ++P W L
Sbjct: 564 HARQEMQTPRTRPRLSAGVAE---VIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLAS 620
Query: 445 M-IEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAA 503
+ R+ +V D I+ GG L +V Y L+ W +VS M
Sbjct: 621 LPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLV 680
Query: 504 VGSIVYVLAGFQGVGRLGHILEYNTETDKWVA 535
+Y L G G + H+ Y+T T++W A
Sbjct: 681 YDGKIYTLGGLGVAGNVDHVERYDTITNQWEA 712
Score = 41.2 bits (95), Expect = 0.003
Identities = 41/142 (28%), Positives = 60/142 (42%), Gaps = 15/142 (10%)
Query: 272 RIALFGGSQPQS-----CRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFP 326
+I +FGG + + P+ +W+ I P + A V + V+ILGG+
Sbjct: 731 KIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGGAY--- 787
Query: 327 IKRMDCYNVVKDSWYSKLGPPT--PRDSLAACAAEGKIYTSGG--SEVGNSALYLFECYD 382
+ Y+ K + K GP R +A +GKIY +GG S G AL E Y+
Sbjct: 788 ARATTIYDPEKGN--IKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEG-PALGNMEAYE 844
Query: 383 TRTESWHTKPSMLTQRCSHGMV 404
T +W P M HG V
Sbjct: 845 PTTNTWTLLPHMPCPVFRHGCV 866
>gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain
containing 9 [Homo sapiens]
Length = 875
Score = 206 bits (524), Expect = 5e-53
Identities = 142/465 (30%), Positives = 226/465 (48%), Gaps = 22/465 (4%)
Query: 19 KTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLES-----KSFEVELKDAEPDII 73
K D+ ++V+ R+ H+ VLA+ S +F + ++ +S + E+ L + + D++
Sbjct: 326 KAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLSNLQADVL 385
Query: 74 EQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAEC 133
E L+EF YT + ++S N ++LL+AA+++Q K+CV FL++Q+ ASNCLG+ +AE
Sbjct: 386 ELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGVLAMAEA 445
Query: 134 LDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWL 193
+ C EL A F Q F EV +E L + ++ D+L +AE+ VY+ ++W+
Sbjct: 446 MQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWI 505
Query: 194 KYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPE 253
K D R + ++LA VR P I ++L V E LI+ + C +V RYH+L
Sbjct: 506 KKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHMLPHA 565
Query: 254 DREELVDGTRPRRKKHDYR-IALFGGSQP--------QSCRYFNPKDYSWTDI-RCPFEK 303
+E TRPR I L GG Q + +NP++ W + PF
Sbjct: 566 RQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYD 625
Query: 304 RRDAACVFWDNVVYILGGSQL-FPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKI 362
R + V + +Y+ GG + + + CY + D+W PR + +GKI
Sbjct: 626 REFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKI 685
Query: 363 YTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVS 422
YT GG V + ++ E YDT T W + S G IYV GG N +
Sbjct: 686 YTLGGLGVAGNVDHV-ERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGV---NEA 741
Query: 423 GRVLNSCEVYDPATETWTEL-CPMIEARKNHGLVFVKDKIFAVGG 466
GR + Y P T TW+ + PMI+ K V + +F +GG
Sbjct: 742 GRAAGVLQSYVPQTNTWSFIESPMID-NKYAPAVTLNGFVFILGG 785
Score = 74.3 bits (181), Expect = 3e-13
Identities = 53/191 (27%), Positives = 81/191 (42%), Gaps = 8/191 (4%)
Query: 347 PTPRDSLAACAAEGKIYTSGGSEVGNS--ALYLFECYDTRTESWHTKPSM-LTQRCSHGM 403
P R L+A AE + G VG + +L C++ + W+ S+ R +
Sbjct: 572 PRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSV 631
Query: 404 VEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFA 463
V A IY+ GG SG L Y + W + M R H + KI+
Sbjct: 632 VSAGDNIYLSGGM----ESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYT 687
Query: 464 VGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHI 523
+GG G +D+VE YD N+W+ V+P+P + G +YV G GR +
Sbjct: 688 LGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGV 747
Query: 524 LE-YNTETDKW 533
L+ Y +T+ W
Sbjct: 748 LQSYVPQTNTW 758
Score = 45.4 bits (106), Expect = 1e-04
Identities = 39/152 (25%), Positives = 61/152 (40%), Gaps = 8/152 (5%)
Query: 389 HTKPSMLTQRC----SHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCP 444
H + M T R S G+ E +I + GG ++ R L + ++P W L
Sbjct: 564 HARQEMQTPRTRPRLSAGVAE---VIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLAS 620
Query: 445 M-IEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAA 503
+ R+ +V D I+ GG L +V Y L+ W +VS M
Sbjct: 621 LPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLV 680
Query: 504 VGSIVYVLAGFQGVGRLGHILEYNTETDKWVA 535
+Y L G G + H+ Y+T T++W A
Sbjct: 681 YDGKIYTLGGLGVAGNVDHVERYDTITNQWEA 712
Score = 41.2 bits (95), Expect = 0.003
Identities = 41/142 (28%), Positives = 60/142 (42%), Gaps = 15/142 (10%)
Query: 272 RIALFGGSQPQS-----CRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFP 326
+I +FGG + + P+ +W+ I P + A V + V+ILGG+
Sbjct: 731 KIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGGAY--- 787
Query: 327 IKRMDCYNVVKDSWYSKLGPPT--PRDSLAACAAEGKIYTSGG--SEVGNSALYLFECYD 382
+ Y+ K + K GP R +A +GKIY +GG S G AL E Y+
Sbjct: 788 ARATTIYDPEKGN--IKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEG-PALGNMEAYE 844
Query: 383 TRTESWHTKPSMLTQRCSHGMV 404
T +W P M HG V
Sbjct: 845 PTTNTWTLLPHMPCPVFRHGCV 866
>gi|8922854 kelch-like 26 [Homo sapiens]
Length = 615
Score = 205 bits (521), Expect = 1e-52
Identities = 153/538 (28%), Positives = 246/538 (45%), Gaps = 36/538 (6%)
Query: 21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFA 80
L DV+L + PAH+VVLAA S +F MFT M E+ +ELK + +++FA
Sbjct: 62 LLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREASQDVIELKGVSARGLRHIIDFA 121
Query: 81 YTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELK 140
Y+A ++++ + VQ +L AA Q+ PV ++C +FLK + CL I +A L+
Sbjct: 122 YSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMSVETCLNIGQMATTFSLASLR 181
Query: 141 ATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNR 200
+ D F +HF ++ + ++FL+L ++R+ L + L AE ++ AAVRWL++D P R
Sbjct: 182 ESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQSCAEIDLFRAAVRWLQHD-PAR 240
Query: 201 QPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREELVD 260
+P +L +RFPL+ + L +VQ ++ ++ C + ++ Y +L R+ +
Sbjct: 241 RPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLCRQYLLEAFNYQVL--PFRQHEMQ 298
Query: 261 GTRPRRKKHDYRIALFGGS-QPQSCRYFNPKDYSWTDIRC-------PFEKRRDAACV-F 311
R + + FGG+ S R + K Y + E CV
Sbjct: 299 SPRTAVRSDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPGARHFRELTEMEVGCSHTCVAV 358
Query: 312 WDNVVYILGGSQL------FPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTS 365
DN VY+ GG L + Y+ + W R G +Y +
Sbjct: 359 LDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQAMQESRIQFQLNVLCGMVYAT 418
Query: 366 GGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRV 425
GG S L E Y R W S+ + H + G +Y+ GG G +V +
Sbjct: 419 GGRNRAGS-LASVERYCPRRNEWGYACSLKRRTWGHAGAASGGRLYISGG-YGISVEDKK 476
Query: 426 LNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDN------VEYY 479
C YDP + W PM E R H +V +I+A+GG+ + +D VEYY
Sbjct: 477 ALHC--YDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGR--MDHVDRCFDVLAVEYY 532
Query: 480 DIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRL----GHILEYNTETDKW 533
+ ++W VSPM C + +Y++ G+ RL G + YNT+TD+W
Sbjct: 533 VPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYN--WRLNNVTGIVQVYNTDTDEW 588
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 199 bits (505), Expect = 7e-51
Identities = 135/520 (25%), Positives = 230/520 (44%), Gaps = 47/520 (9%)
Query: 15 INLKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIE 74
+ ++ L DVIL V ++ HRVVLAAAS++F MF ++ E + +K + + +
Sbjct: 65 LRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAETMH 124
Query: 75 QLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECL 134
L+++ YT++ + NVQ +L+AAN +Q + C FL E ++ NC+GI LA+
Sbjct: 125 TLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLADTH 184
Query: 135 DCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLK 194
LK +I Q+F ++ ++EFL L V + H+L D L V E QV++ + W++
Sbjct: 185 SLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMSWVR 244
Query: 195 YDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPED 254
+ R + +L VR PL+ + +TV+A+PLI+ PE ++ YHL
Sbjct: 245 HKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHL---SG 301
Query: 255 REELVDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDN 314
E + + T+PR + + + G + R+ ++ C RR V
Sbjct: 302 NEIISERTKPRMHEFQSEVFMIIGGCTKDERFV-------AEVTCLDPLRRSRLEV---- 350
Query: 315 VVYILGGSQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSA 374
P+ + + K W A + ++Y SGG E +
Sbjct: 351 --------AKLPLTEHELESENK-KWV----------EFACVTLKNEVYISGGKETQHDV 391
Query: 375 LYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDP 434
Y++ W + R H MV G +YV GG G + +N+ E YDP
Sbjct: 392 WK----YNSSINKWIQIEYLNIGRWRHKMVVLGGKVYVIGGFDGL----QRINNVETYDP 443
Query: 435 ATETWTELCPMIEARKNHGLVFVKDKIFAV-GGQNGLGGLDNVEYYDIKLNEWKMVSPMP 493
W+E P++ + K K++ + GG NG D + YD N+W + + MP
Sbjct: 444 FHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMP 503
Query: 494 WKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 533
+ + + +YV+ G + + Y+ D W
Sbjct: 504 VEAKCINAVSFRDRIYVVG-----GAMRALYAYSPLEDSW 538
Score = 51.2 bits (121), Expect = 2e-06
Identities = 36/145 (24%), Positives = 60/145 (41%), Gaps = 11/145 (7%)
Query: 316 VYILGGSQ--LFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNS 373
+Y++GG + CY+ + W K P + A + +IY GG+
Sbjct: 470 LYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGGAM---R 526
Query: 374 ALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYD 433
ALY Y +SW + +R S G+ N +Y+ GG N V+ + +D
Sbjct: 527 ALY---AYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKN---EVIATVLCWD 580
Query: 434 PATETWTELCPMIEARKNHGLVFVK 458
P + TE C + +HG V ++
Sbjct: 581 PEAQKLTEECVLPRGVSHHGSVTIR 605
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 197 bits (501), Expect = 2e-50
Identities = 134/540 (24%), Positives = 240/540 (44%), Gaps = 29/540 (5%)
Query: 15 INLKKTLCDVILMVQERK--IPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDI 72
+ L+ LCDV LM + P HRV++A+AS +F MFT M E ++L
Sbjct: 85 LRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVG 144
Query: 73 IEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAE 132
+ ++++F YTA++S+N +N+Q L+AA+ QI PV C FL V NC+ + +A
Sbjct: 145 LRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIAN 204
Query: 133 CLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRW 192
+ E+ + F+ ++F + T EFL+L +R+ +L+ ++L E +++ A RW
Sbjct: 205 TYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRW 264
Query: 193 LKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSP 252
L+ +EP R F ++ +RFPL++ L VQ ++ + C+ +++ Y ++
Sbjct: 265 LRLEEP-RMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMM-- 321
Query: 253 EDREELVDGTRPRRKKHDYRIALFGGSQPQ------SCRYFNPKDYSWTDIRCPFEKRRD 306
+ ++ R + + GG Q R ++ K + W + R
Sbjct: 322 PYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQ 381
Query: 307 AACVFWDNVVYILGGSQLFPIKRMDCYNVV------KDSWYSKLGPPTPRDSLAACAAEG 360
N +Y++GG + K + V + W R A +G
Sbjct: 382 HGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKG 441
Query: 361 KIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNN 420
+Y GG L ECY+ RT W M H G++Y+ GG +
Sbjct: 442 YLYAVGGRNAAGE-LPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDT 500
Query: 421 VSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLD-----N 475
++ +DP T+ W + PM R H + V ++++ +GG + G D +
Sbjct: 501 FQKELM----CFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLS 556
Query: 476 VEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGR--LGHILEYNTETDKW 533
EYY L++W ++ M V A + +YV+ G+ R + + +Y+ + D+W
Sbjct: 557 CEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEW 616
Score = 76.6 bits (187), Expect = 5e-14
Identities = 43/172 (25%), Positives = 75/172 (43%), Gaps = 1/172 (0%)
Query: 381 YDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRV-LNSCEVYDPATETW 439
YD + W + M R HG+ +YV GG + G+ +++ +DP W
Sbjct: 362 YDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKW 421
Query: 440 TELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTV 499
++ + E R L +K ++AVGG+N G L VE Y+ + NEW V+ M
Sbjct: 422 MQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGH 481
Query: 500 KCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVRAFPVTSCLICV 551
G ++Y+ G ++ ++ +TDKW+ + + C+ V
Sbjct: 482 AGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTV 533
Score = 58.9 bits (141), Expect = 1e-08
Identities = 32/120 (26%), Positives = 54/120 (45%), Gaps = 5/120 (4%)
Query: 425 VLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQN-----GLGGLDNVEYY 479
V +YD W L PM R HG+ + + ++ VGGQ+ G +D V +
Sbjct: 355 VSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRF 414
Query: 480 DIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKV 539
D + N+W V+ + K +A+ +Y + G G L + YN T++W +K+
Sbjct: 415 DPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKM 474
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.421
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,682,817
Number of Sequences: 37866
Number of extensions: 948599
Number of successful extensions: 3016
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 166
Number of HSP's successfully gapped in prelim test: 19
Number of HSP's that attempted gapping in prelim test: 1841
Number of HSP's gapped (non-prelim): 348
length of query: 564
length of database: 18,247,518
effective HSP length: 108
effective length of query: 456
effective length of database: 14,157,990
effective search space: 6456043440
effective search space used: 6456043440
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.