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Search of human proteins with 17017982
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
(718 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 1473 0.0
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 1437 0.0
gi|14780904 kelch-like 1 protein [Homo sapiens] 958 0.0
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 926 0.0
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 926 0.0
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 838 0.0
gi|40807500 kelch-like 20 [Homo sapiens] 466 e-131
gi|38194229 kelch-like 17 [Homo sapiens] 445 e-125
gi|166235129 kelch-like 3 [Homo sapiens] 404 e-112
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 404 e-112
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 401 e-111
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 401 e-111
gi|34101268 kelch-like 8 [Homo sapiens] 400 e-111
gi|11056006 kelch-like 12 [Homo sapiens] 399 e-111
gi|55925604 kelch-like 18 [Homo sapiens] 397 e-110
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 359 4e-99
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 342 5e-94
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 342 5e-94
gi|148664209 kelch-like 10 [Homo sapiens] 325 1e-88
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 322 8e-88
gi|223890235 intracisternal A particle-promoted polypeptide isof... 318 8e-87
gi|45643138 kelch-like 13 [Homo sapiens] 273 4e-73
gi|24308181 kelch-like 9 [Homo sapiens] 268 1e-71
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 265 8e-71
gi|40018614 DRE1 protein [Homo sapiens] 265 8e-71
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens] 260 4e-69
gi|24475847 influenza virus NS1A binding protein [Homo sapiens] 251 2e-66
gi|8922854 kelch-like 26 [Homo sapiens] 249 5e-66
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens] 245 1e-64
gi|109150407 kelch-like 6 [Homo sapiens] 244 3e-64
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 1473 bits (3814), Expect = 0.0
Identities = 718/718 (100%), Positives = 718/718 (100%)
Query: 1 MSVSGKKEFDVKQILRLRWRWFSHPFQGSTNTGSCLQQEGYEHRGTPVQGRLKSHSRDRN 60
MSVSGKKEFDVKQILRLRWRWFSHPFQGSTNTGSCLQQEGYEHRGTPVQGRLKSHSRDRN
Sbjct: 1 MSVSGKKEFDVKQILRLRWRWFSHPFQGSTNTGSCLQQEGYEHRGTPVQGRLKSHSRDRN 60
Query: 61 GLKKSNSPVHHNILAPVPGPAPAHQRAVQNLQQHNLIVHFQANEDTPKSVPEKNLFKEAC 120
GLKKSNSPVHHNILAPVPGPAPAHQRAVQNLQQHNLIVHFQANEDTPKSVPEKNLFKEAC
Sbjct: 61 GLKKSNSPVHHNILAPVPGPAPAHQRAVQNLQQHNLIVHFQANEDTPKSVPEKNLFKEAC 120
Query: 121 EKRAQDLEMMADDNIEDSTARLDTQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEKQ 180
EKRAQDLEMMADDNIEDSTARLDTQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEKQ
Sbjct: 121 EKRAQDLEMMADDNIEDSTARLDTQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEKQ 180
Query: 181 LCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYA 240
LCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYA
Sbjct: 181 LCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYA 240
Query: 241 YTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELL 300
YTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELL
Sbjct: 241 YTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELL 300
Query: 301 NVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNR 360
NVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNR
Sbjct: 301 NVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNR 360
Query: 361 QGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPR 420
QGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPR
Sbjct: 361 QGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPR 420
Query: 421 TKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYV 480
TKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYV
Sbjct: 421 TKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYV 480
Query: 481 VGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTV 540
VGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTV
Sbjct: 481 VGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTV 540
Query: 541 ERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLC 600
ERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLC
Sbjct: 541 ERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLC 600
Query: 601 APMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPR 660
APMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPR
Sbjct: 601 APMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPR 660
Query: 661 DAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVVVKLP 718
DAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVVVKLP
Sbjct: 661 DAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVVVKLP 718
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 1437 bits (3719), Expect = 0.0
Identities = 699/701 (99%), Positives = 700/701 (99%)
Query: 1 MSVSGKKEFDVKQILRLRWRWFSHPFQGSTNTGSCLQQEGYEHRGTPVQGRLKSHSRDRN 60
MSVSGKKEFDVKQILRLRWRWFSHPFQGSTNTGSCLQQEGYEHRGTPVQGRLKSHSRDRN
Sbjct: 1 MSVSGKKEFDVKQILRLRWRWFSHPFQGSTNTGSCLQQEGYEHRGTPVQGRLKSHSRDRN 60
Query: 61 GLKKSNSPVHHNILAPVPGPAPAHQRAVQNLQQHNLIVHFQANEDTPKSVPEKNLFKEAC 120
GLKKSNSPVHHNILAPVPGPAPAHQRAVQNLQQHNLIVHFQANEDTPKSVPEKNLFKEAC
Sbjct: 61 GLKKSNSPVHHNILAPVPGPAPAHQRAVQNLQQHNLIVHFQANEDTPKSVPEKNLFKEAC 120
Query: 121 EKRAQDLEMMADDNIEDSTARLDTQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEKQ 180
EKRAQDLEMMADDNIEDSTARLDTQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEKQ
Sbjct: 121 EKRAQDLEMMADDNIEDSTARLDTQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEKQ 180
Query: 181 LCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYA 240
LCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYA
Sbjct: 181 LCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYA 240
Query: 241 YTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELL 300
YTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELL
Sbjct: 241 YTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELL 300
Query: 301 NVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNR 360
NVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNR
Sbjct: 301 NVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNR 360
Query: 361 QGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPR 420
QGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPR
Sbjct: 361 QGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPR 420
Query: 421 TKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYV 480
TKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYV
Sbjct: 421 TKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYV 480
Query: 481 VGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTV 540
VGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTV
Sbjct: 481 VGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTV 540
Query: 541 ERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLC 600
ERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLC
Sbjct: 541 ERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLC 600
Query: 601 APMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPR 660
APMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPR
Sbjct: 601 APMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPR 660
Query: 661 DAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEV 701
DAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKE +
Sbjct: 661 DAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKESM 701
Score = 151 bits (381), Expect = 2e-36
Identities = 76/190 (40%), Positives = 109/190 (57%), Gaps = 6/190 (3%)
Query: 523 GPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSS 582
G +YAVGG D T+E++D W ++ +M+ R GV ++NKLY +GGRDG
Sbjct: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLK 488
Query: 583 CLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVER 642
L ++E F+P W++ PMS R G+GVAT G +Y VGGHD + + VER
Sbjct: 489 TLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWS------YLNTVER 542
Query: 643 YDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVP 702
+DP+G W+ VA +S PR V V L +KLY +GG DG + L ++E +D N+W P
Sbjct: 543 WDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAP 602
Query: 703 VNIGRAGACV 712
++ R G V
Sbjct: 603 MSKRRGGVGV 612
Score = 96.3 bits (238), Expect = 9e-20
Identities = 58/171 (33%), Positives = 83/171 (48%), Gaps = 12/171 (7%)
Query: 545 PEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMS 604
PE R +STVG LYA+GG D ++E +D TN W M+
Sbjct: 410 PERRSMMQSPRTKPRKSTVGA------LYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMN 463
Query: 605 KRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVA 664
RR GVA + LYVVGG D + + VE ++P G W+ + P+S R +
Sbjct: 464 GRRLQFGVAVIDNKLYVVGGRDG------LKTLNTVECFNPVGKIWTVMPPMSTHRHGLG 517
Query: 665 VCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVVV 715
V L +Y VGG+DG +YLNTVE +D + +W ++ R+ VV +
Sbjct: 518 VATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVAL 568
Score = 57.0 bits (136), Expect = 6e-08
Identities = 35/102 (34%), Positives = 51/102 (50%), Gaps = 6/102 (5%)
Query: 617 GFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVG 676
G LY VGG DA + +E+YD + +SW + ++ R V + +KLYVVG
Sbjct: 429 GALYAVGGMDAMKG------TTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVG 482
Query: 677 GYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVVVKLP 718
G DG LNTVE ++ W P++ R G V ++ P
Sbjct: 483 GRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGP 524
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 958 bits (2477), Expect = 0.0
Identities = 488/753 (64%), Positives = 578/753 (76%), Gaps = 40/753 (5%)
Query: 1 MSVSGKKEFDVKQILRLRWRWFSHPFQ--GSTNTGSCLQQEG---YEHRGTPVQGRLKSH 55
MS SG+K+FDVK ILRLRW+ FSHP G G CLQQ+G +EH G P Q RL
Sbjct: 1 MSGSGRKDFDVKHILRLRWKLFSHPSPSTGGPAGGGCLQQDGSGSFEHWG-PSQSRLLK- 58
Query: 56 SRDRNGLK-----------KSNSPVH--------HNILAPVPGPAPAHQRAVQNLQQHNL 96
S++R+G+ S+SP + L PV Q
Sbjct: 59 SQERSGVSTFWKKPSSSSSSSSSPSSSSSSFNPLNGTLLPVATRLQQGAPGQGTQQPART 118
Query: 97 IVHFQANEDTPKSVPEKNLFKEACEKRAQDLEMMAD-DNIEDSTAR------LDTQHS-- 147
+ + ++ E+ + VP + F EK E+ + DN +T T HS
Sbjct: 119 LFYVESLEE--EVVPGMD-FPGPHEKGLVLQELKVEPDNSSQATGEGCGHRLSSTGHSMT 175
Query: 148 --EDMNATRSEEQFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSD 205
D++++ SEE + ++HAEQT RKME+YLK++QLCDV+LI G+ +IPAHRLVLS+VSD
Sbjct: 176 PQSDLDSSSSEEFYQAVHHAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSD 235
Query: 206 YFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLT 265
YFAAMFT+DV EAKQEE++MEG+DPNAL LVQ+AYTG L+LKEDTIE+LLAAACLLQL
Sbjct: 236 YFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLP 295
Query: 266 QVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPA 325
QV++VC +FL+K LHPSNCLGIR+F DAQGC EL+ VAH YTME+ +EVI+NQEFLLLPA
Sbjct: 296 QVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPA 355
Query: 326 NEISKLLCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLADLE 385
E+ KLL SDD+NVPDEETIFHALM WV +D+Q+R +L MLL++IRLPLLPPQ+LADLE
Sbjct: 356 EELHKLLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILADLE 415
Query: 386 TSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTT 445
++F DLECQKL++EAMKYHLLPERR++MQSPRTKPRKSTVG LYAVGGMD KG TT
Sbjct: 416 NHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATT 475
Query: 446 IEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTV 505
IEKYDLRTN W+ G MNGRRLQFGVAVID+KL+V+GGRDGLKTLNTVEC+NP K WTV
Sbjct: 476 IEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTV 535
Query: 506 MPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGV 565
+PPMSTHRHGLGV LEGP+YAVGGHDGWSYLNTVERWDP+ +QW +VASMS RSTVGV
Sbjct: 536 LPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGV 595
Query: 566 VALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGH 625
ALN KLY++GGRDGSSCL SMEY+DPHTNKW++CAPM KRRGGVGVAT +GFLY VGGH
Sbjct: 596 AALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGH 655
Query: 626 DAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLN 685
DAPASNHCSRL D VERYDPK D+W+ VAPLS+PRDAV VC LGD+LY VGGYDG TYLN
Sbjct: 656 DAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLN 715
Query: 686 TVESYDAQRNEWKEEVPVNIGRAGACVVVVKLP 718
T+ESYD Q NEW + +NIGRAGACVVV+K P
Sbjct: 716 TMESYDPQTNEWTQMASLNIGRAGACVVVIKQP 748
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 926 bits (2394), Expect = 0.0
Identities = 463/728 (63%), Positives = 554/728 (76%), Gaps = 39/728 (5%)
Query: 6 KKEFDVKQILRLRWRWFSHPFQGSTNTGSCLQQEGYEHRGTPVQGRLKSHSRDRNGLKKS 65
+KEFDVKQIL++RWRWF H S N+ QQ + +RG NG +K
Sbjct: 5 RKEFDVKQILKIRWRWFGHQ-ASSPNSTVDSQQGEFWNRG----------QTGANGGRKF 53
Query: 66 NSPVHHNILAPVPGPAPAHQRAVQNLQQHNLIVHFQANEDTPKS----VPEKNLFKEAC- 120
P + P + ++R+ Q + FQ + P + VP E C
Sbjct: 54 LDPCSLQL----PLASIGYRRSSQ--------LDFQNSPSWPMASTSEVPAFEFTAEDCG 101
Query: 121 -----EKRAQDLEMMADDNIEDSTARLDTQHSEDMNATR------SEEQFHVINHAEQTL 169
++ D ++N DS++ + S+ +++ S+E F +NHAEQT
Sbjct: 102 GAHWLDRPEVDDGTSEEENESDSSSCRTSNSSQTLSSCHTMEPCTSDEFFQALNHAEQTF 161
Query: 170 RKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVD 229
+KMENYL+ KQLCDV+L+AG RIPAHRLVLS+VSDYFAAMFTNDV EA+QEE++MEGV+
Sbjct: 162 KKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVE 221
Query: 230 PNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRS 289
PN+L SL+QYAYTG L+LKED IE LL+ ACLLQL+QV++ C FL+KQLHPSNCLGIRS
Sbjct: 222 PNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRS 281
Query: 290 FGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHAL 349
F DAQGCT+L VAH YTMEHF+EVI+NQEF+LLPA+EI+KLL SDD+N+P+EETI +AL
Sbjct: 282 FADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNAL 341
Query: 350 MQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLL 409
+ WV HD++ R+ +L LL+YIRLPLL PQ LAD+E + +F D+ECQKL+MEAMKYHLL
Sbjct: 342 LTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADMENNVLFRDDIECQKLIMEAMKYHLL 401
Query: 410 PERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQF 469
PERR M+QSPRTKPRKSTVG L+AVGGMD+ KG T+IEKYDLRTN W + MNGRRLQF
Sbjct: 402 PERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQF 461
Query: 470 GVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVG 529
GVAV+D+KLYVVGGRDGLKTLNTVEC+NP K W+VMPPMSTHRHGLGVA LEGPMYAVG
Sbjct: 462 GVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVG 521
Query: 530 GHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEY 589
GHDGWSYLNTVERWDP+ RQWN+VA+MSTPRSTVGV L+ KLYA+GGRDGSSCLKS+E
Sbjct: 522 GHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVEC 581
Query: 590 FDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDS 649
FDPHTNKW+LCA MSKRRGGVGV T+NG LY +GGHDAPASN SRLSDCVERYDPK D
Sbjct: 582 FDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDM 641
Query: 650 WSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAG 709
W+ VA +S+ RDAV VC LGDKLY VGGYDG YLNTVE+YD Q NEW + P+ +GRAG
Sbjct: 642 WTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAG 701
Query: 710 ACVVVVKL 717
ACVV VKL
Sbjct: 702 ACVVTVKL 709
Score = 65.9 bits (159), Expect = 1e-10
Identities = 51/154 (33%), Positives = 75/154 (48%), Gaps = 19/154 (12%)
Query: 569 NNKLYAIGGRDGSSCLK----SMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGG 624
NN L+ RD C K +M+Y + L +P +K R G L+ VGG
Sbjct: 378 NNVLF----RDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTV-----GTLFAVGG 428
Query: 625 HDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYL 684
D+ ++ + +E+YD + + W+ VA ++ R V L DKLYVVGG DG L
Sbjct: 429 MDS------TKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTL 482
Query: 685 NTVESYDAQRNEWKEEVPVNIGRAGACVVVVKLP 718
NTVE Y+ + W P++ R G V V++ P
Sbjct: 483 NTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGP 516
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 926 bits (2394), Expect = 0.0
Identities = 463/728 (63%), Positives = 554/728 (76%), Gaps = 39/728 (5%)
Query: 6 KKEFDVKQILRLRWRWFSHPFQGSTNTGSCLQQEGYEHRGTPVQGRLKSHSRDRNGLKKS 65
+KEFDVKQIL++RWRWF H S N+ QQ + +RG NG +K
Sbjct: 51 RKEFDVKQILKIRWRWFGHQ-ASSPNSTVDSQQGEFWNRG----------QTGANGGRKF 99
Query: 66 NSPVHHNILAPVPGPAPAHQRAVQNLQQHNLIVHFQANEDTPKS----VPEKNLFKEAC- 120
P + P + ++R+ Q + FQ + P + VP E C
Sbjct: 100 LDPCSLQL----PLASIGYRRSSQ--------LDFQNSPSWPMASTSEVPAFEFTAEDCG 147
Query: 121 -----EKRAQDLEMMADDNIEDSTARLDTQHSEDMNATR------SEEQFHVINHAEQTL 169
++ D ++N DS++ + S+ +++ S+E F +NHAEQT
Sbjct: 148 GAHWLDRPEVDDGTSEEENESDSSSCRTSNSSQTLSSCHTMEPCTSDEFFQALNHAEQTF 207
Query: 170 RKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVD 229
+KMENYL+ KQLCDV+L+AG RIPAHRLVLS+VSDYFAAMFTNDV EA+QEE++MEGV+
Sbjct: 208 KKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVE 267
Query: 230 PNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRS 289
PN+L SL+QYAYTG L+LKED IE LL+ ACLLQL+QV++ C FL+KQLHPSNCLGIRS
Sbjct: 268 PNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRS 327
Query: 290 FGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHAL 349
F DAQGCT+L VAH YTMEHF+EVI+NQEF+LLPA+EI+KLL SDD+N+P+EETI +AL
Sbjct: 328 FADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNAL 387
Query: 350 MQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLL 409
+ WV HD++ R+ +L LL+YIRLPLL PQ LAD+E + +F D+ECQKL+MEAMKYHLL
Sbjct: 388 LTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADMENNVLFRDDIECQKLIMEAMKYHLL 447
Query: 410 PERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQF 469
PERR M+QSPRTKPRKSTVG L+AVGGMD+ KG T+IEKYDLRTN W + MNGRRLQF
Sbjct: 448 PERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQF 507
Query: 470 GVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVG 529
GVAV+D+KLYVVGGRDGLKTLNTVEC+NP K W+VMPPMSTHRHGLGVA LEGPMYAVG
Sbjct: 508 GVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVG 567
Query: 530 GHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEY 589
GHDGWSYLNTVERWDP+ RQWN+VA+MSTPRSTVGV L+ KLYA+GGRDGSSCLKS+E
Sbjct: 568 GHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVEC 627
Query: 590 FDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDS 649
FDPHTNKW+LCA MSKRRGGVGV T+NG LY +GGHDAPASN SRLSDCVERYDPK D
Sbjct: 628 FDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDM 687
Query: 650 WSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAG 709
W+ VA +S+ RDAV VC LGDKLY VGGYDG YLNTVE+YD Q NEW + P+ +GRAG
Sbjct: 688 WTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAG 747
Query: 710 ACVVVVKL 717
ACVV VKL
Sbjct: 748 ACVVTVKL 755
Score = 65.9 bits (159), Expect = 1e-10
Identities = 51/154 (33%), Positives = 75/154 (48%), Gaps = 19/154 (12%)
Query: 569 NNKLYAIGGRDGSSCLK----SMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGG 624
NN L+ RD C K +M+Y + L +P +K R G L+ VGG
Sbjct: 424 NNVLF----RDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTV-----GTLFAVGG 474
Query: 625 HDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYL 684
D+ ++ + +E+YD + + W+ VA ++ R V L DKLYVVGG DG L
Sbjct: 475 MDS------TKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTL 528
Query: 685 NTVESYDAQRNEWKEEVPVNIGRAGACVVVVKLP 718
NTVE Y+ + W P++ R G V V++ P
Sbjct: 529 NTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGP 562
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 838 bits (2165), Expect = 0.0
Identities = 394/521 (75%), Positives = 453/521 (86%)
Query: 197 RLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLL 256
RLVLS+VSDYFAAMFTNDV EA+QEE++MEGV+PN+L SL+QYAYTG L+LKED IE LL
Sbjct: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
Query: 257 AAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIK 316
+ ACLLQL+QV++ C FL+KQLHPSNCLGIRSF DAQGCT+L VAH YTMEHF+EVI+
Sbjct: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
Query: 317 NQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLL 376
NQEF+LLPA+EI+KLL SDD+N+P+EETI +AL+ WV HD++ R+ +L LL+YIRLPLL
Sbjct: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353
Query: 377 PPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGG 436
PQ LAD+E + +F D+ECQKL+MEAMKYHLLPERR M+QSPRTKPRKSTVG L+AVGG
Sbjct: 354 APQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGG 413
Query: 437 MDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECF 496
MD+ KG T+IEKYDLRTN W + MNGRRLQFGVAV+D+KLYVVGGRDGLKTLNTVEC+
Sbjct: 414 MDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECY 473
Query: 497 NPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASM 556
NP K W+VMPPMSTHRHGLGVA LEGPMYAVGGHDGWSYLNTVERWDP+ RQWN+VA+M
Sbjct: 474 NPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATM 533
Query: 557 STPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYN 616
STPRSTVGV L+ KLYA+GGRDGSSCLKS+E FDPHTNKW+LCA MSKRRGGVGV T+N
Sbjct: 534 STPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWN 593
Query: 617 GFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVG 676
G LY +GGHDAPASN SRLSDCVERYDPK D W+ VA +S+ RDAV VC LGDKLY VG
Sbjct: 594 GLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVG 653
Query: 677 GYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVVVKL 717
GYDG YLNTVE+YD Q NEW + P+ +GRAGACVV VKL
Sbjct: 654 GYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL 694
Score = 65.9 bits (159), Expect = 1e-10
Identities = 51/154 (33%), Positives = 75/154 (48%), Gaps = 19/154 (12%)
Query: 569 NNKLYAIGGRDGSSCLK----SMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGG 624
NN L+ RD C K +M+Y + L +P +K R G L+ VGG
Sbjct: 363 NNVLF----RDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTV-----GTLFAVGG 413
Query: 625 HDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYL 684
D+ ++ + +E+YD + + W+ VA ++ R V L DKLYVVGG DG L
Sbjct: 414 MDS------TKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTL 467
Query: 685 NTVESYDAQRNEWKEEVPVNIGRAGACVVVVKLP 718
NTVE Y+ + W P++ R G V V++ P
Sbjct: 468 NTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGP 501
Score = 45.1 bits (105), Expect = 2e-04
Identities = 21/48 (43%), Positives = 26/48 (54%)
Query: 6 KKEFDVKQILRLRWRWFSHPFQGSTNTGSCLQQEGYEHRGTPVQGRLK 53
+KEFDVKQIL++RWRWF H +T Q E + T G K
Sbjct: 51 RKEFDVKQILKIRWRWFGHQASSPNSTVDSQQGEFWNRGQTGANGGRK 98
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 466 bits (1198), Expect = e-131
Identities = 241/558 (43%), Positives = 351/558 (62%), Gaps = 10/558 (1%)
Query: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEV 223
H QTL + K ++LCDV+L+ G +I AHR++LSA S YF AMFT ++ E++Q EV
Sbjct: 50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEV 109
Query: 224 RMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSN 283
+ +D A+ L+ +AYT + ++E +++LL AACLLQL ++ + C FL +QL PSN
Sbjct: 110 VIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSN 169
Query: 284 CLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEE 343
CLGIR+F D C ELL +A K+T +F EV++++EF+LLPAN++ ++ SD++NV EE
Sbjct: 170 CLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEE 229
Query: 344 TIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LLADLETSSMFTGDLECQKLLME 402
+F+A+M WV + +Q R+ +L +L ++RLPLL P+ L+ + + + D EC+ L+ E
Sbjct: 230 QVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDE 289
Query: 403 AMKYHLLPERRSMMQSPRTKPRK--STVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIG 460
A Y LLP+ R +MQ PRT+PRK L+AVGG + +++E+YD +TN W +
Sbjct: 290 AKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVA 349
Query: 461 TMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTV-MPPMSTHRHGLGVA 519
+M+ RR GV+V+D+ LY VGG DG LN+VE ++P W+ + P ST R +GVA
Sbjct: 350 SMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVA 409
Query: 520 TLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRD 579
L G +YAVGG DG S LN VER+DP+ +W VASMST R V V L LYA+GG D
Sbjct: 410 VLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSD 469
Query: 580 GSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDC 639
G+S L ++E ++P N+W APM RR +G A Y +Y VGG D + LS
Sbjct: 470 GTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRD-----DTTELSS- 523
Query: 640 VERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKE 699
ERY+P+ + WS V ++ R V + + +L VGG+DG TYL T+E +D N W+
Sbjct: 524 AERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRL 583
Query: 700 EVPVNIGRAGACVVVVKL 717
+N R G V V+K+
Sbjct: 584 YGGMNYRRLGGGVGVIKM 601
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 445 bits (1144), Expect = e-125
Identities = 233/557 (41%), Positives = 332/557 (59%), Gaps = 9/557 (1%)
Query: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEV 223
H M + LCD++L I AH++VL++ S YF AMFTN++ E++Q V
Sbjct: 74 HYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHV 133
Query: 224 RMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSN 283
+ +DP AL+ LVQ+AYT + + E +++LL AA LLQL V D C FL+ QL PSN
Sbjct: 134 TLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSN 193
Query: 284 CLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEE 343
CLGIR F DA C++LL AH+Y ++HF++V K +EF+LLP ++ +L+ SD +NVP EE
Sbjct: 194 CLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEE 253
Query: 344 TIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LLADLETSSMFTGDLECQKLLME 402
++ A++ WV HDV R+ + L+ +RLPLL LL ++ S+ +C+ LL+E
Sbjct: 254 EVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIE 313
Query: 403 AMKYHLLPERRSMMQSPRTKPRK--STVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIG 460
A+K+HLLPE+R ++ + RT+PR+ L+AVGG E YD RT+ W +
Sbjct: 314 ALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVVA 373
Query: 461 TMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVAT 520
+M+ RR + GVA + N+LY VGG DG L TVE ++PV W M T R LGVA
Sbjct: 374 SMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAA 433
Query: 521 LEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDG 580
L G +Y+ GG+DG S LN+ ER+DP W VA+MST R V V L+ LYA+GG D
Sbjct: 434 LHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDS 493
Query: 581 SSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCV 640
SS L ++E ++P N WS A M RR GVA G LYV GG+D + + V
Sbjct: 494 SSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDG------TSCLNSV 547
Query: 641 ERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEE 700
ERY PK +W +VAP+++ R + + LY VGG DG + LN++E Y+ + N+W
Sbjct: 548 ERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAA 607
Query: 701 VPVNIGRAGACVVVVKL 717
+ R+ V V++L
Sbjct: 608 SCMFTRRSSVGVAVLEL 624
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 404 bits (1037), Expect = e-112
Identities = 224/554 (40%), Positives = 331/554 (59%), Gaps = 17/554 (3%)
Query: 171 KMENYLKEKQL-CDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVD 229
K+ N L+ KQL CDV+++A + I AHR+VL+A S YF AMFT D+ E+K +++ ++ VD
Sbjct: 38 KVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVD 97
Query: 230 PNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRS 289
L+ L+ Y YT +++ E+ ++ LL AA LLQL V C +FL QLHP+NCLGIR+
Sbjct: 98 GQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRA 157
Query: 290 FGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHAL 349
F D CT+LL A+ Y +HF EV+ +EFL L +++ L+ SD + V EE +F A+
Sbjct: 158 FADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAV 217
Query: 350 MQWVGHDVQNRQGELGMLLSYIRLPLLP-PQLLADLETSSMFTGDLECQKLLMEAMKYHL 408
+ W+ ++ + R + L+ ++RLPLLP L+ +E ++ + C+ L+EAMKYHL
Sbjct: 218 ISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHL 277
Query: 409 LP-ERRSMMQSPRTKPRK--STVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGR 465
LP ++R ++++PRTKPR S + VGG A K ++E YD + W I + R
Sbjct: 278 LPLDQRLLIKNPRTKPRTPVSLPKVMIVVGG-QAPKAIRSVECYDFEEDRWDQIAELPSR 336
Query: 466 RLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPM 525
R + GV + +Y VGG +G + TV+ ++ V WT + M R LG A L +
Sbjct: 337 RCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLL 396
Query: 526 YAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSS--C 583
YAVGG DG + L +VE + + +W +VA M+T RS+VGV + KLYA+GG DG+S C
Sbjct: 397 YAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQC 456
Query: 584 LKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERY 643
L ++E ++P TN+W A MS RR G GV +G LY GGHD P + VE Y
Sbjct: 457 LSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPL------VRKSVEVY 510
Query: 644 DPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPV 703
DP ++W VA +++ R VC + LYVVGG DG L +VE Y+ ++W +P
Sbjct: 511 DPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKW-TLLPT 569
Query: 704 NI--GRAGACVVVV 715
N+ GR+ A V V+
Sbjct: 570 NMSTGRSYAGVAVI 583
Score = 103 bits (256), Expect = 7e-22
Identities = 69/205 (33%), Positives = 90/205 (43%), Gaps = 56/205 (27%)
Query: 424 RKSTVGA------LYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNK 477
R+ST+GA LYAVGG D G ++E Y +TN W + MN RR GV V++ K
Sbjct: 383 RRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGK 442
Query: 478 LYVVGGRDGL--KTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYA-------- 527
LY VGG DG + L+TVE +NP W + MST R G GV L G +YA
Sbjct: 443 LYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPL 502
Query: 528 ---------------------------------------VGGHDGWSYLNTVERWDPEGR 548
VGG DG L +VE ++P
Sbjct: 503 VRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTD 562
Query: 549 QWNYV-ASMSTPRSTVGVVALNNKL 572
+W + +MST RS GV ++ L
Sbjct: 563 KWTLLPTNMSTGRSYAGVAVIHKSL 587
Score = 82.0 bits (201), Expect = 2e-15
Identities = 49/151 (32%), Positives = 75/151 (49%), Gaps = 7/151 (4%)
Query: 566 VALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGH 625
V+L + +GG+ ++S+E +D ++W A + RR GV G +Y VGG
Sbjct: 297 VSLPKVMIVVGGQ-APKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGF 355
Query: 626 DAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLN 685
+ S V+ YD D W+++A + R + L D LY VGG+DG T L
Sbjct: 356 NG------SLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLA 409
Query: 686 TVESYDAQRNEWKEEVPVNIGRAGACVVVVK 716
+VE+Y + NEW P+N R+ V VV+
Sbjct: 410 SVEAYSYKTNEWFFVAPMNTRRSSVGVGVVE 440
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 404 bits (1037), Expect = e-112
Identities = 221/549 (40%), Positives = 325/549 (59%), Gaps = 27/549 (4%)
Query: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEV 223
H+EQ L+ + + +LCD++L G ++I AH++VL++VS YF AMFT ++ E + EV
Sbjct: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEV 76
Query: 224 RMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSN 283
+ +D AL ++V+YAYTG + + +DT+ESLL AA LLQ+ V+ C FL QL P N
Sbjct: 77 EFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGN 136
Query: 284 CLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEE 343
C+GI F + GC +L A KY ++F V + +EF L ++ +++ +D +NV EE
Sbjct: 137 CIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEE 196
Query: 344 TIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLADL-ETSSMFTGDLECQKLLME 402
T+F+AL W+ +DVQ RQ L LL+ +RLPLL + L L E + + D C+ LL E
Sbjct: 197 TVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNE 256
Query: 403 AMKYHLLPERR-----SMMQSPRTKPRKSTVGALYAVGGMDAMKG-TTTIEKYDLRTNSW 456
A+KYH +PE R +M PR P+ L AVGG + ++E Y + +SW
Sbjct: 257 ALKYHFMPEHRLSHQTVLMTRPRCAPK-----VLCAVGGKSGLFACLDSVEMYFPQNDSW 311
Query: 457 LHIGTMNGRRLQFGVAVIDNKLYVVGG-----RDGL---KTLNTVECFNPVGKIWTVMPP 508
+ + +N R +FG+ V+D K+YV+GG R G+ K N+VEC+NP WT +
Sbjct: 312 IGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLER 371
Query: 509 MSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVAL 568
M+ R LGV L G +YA+GG+DG SYL +VE++ P+ R+W VA M+T RS L
Sbjct: 372 MNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVL 431
Query: 569 NNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAP 628
+ +YAIGG G + + S+E +DP + W + A M+ +R GV GF++VVGGH
Sbjct: 432 DGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGH--- 487
Query: 629 ASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVE 688
N S LS +ERYDP + W+ P+ PR V + + LYVVGG+ G +YLNTV+
Sbjct: 488 --NGVSHLSS-IERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQ 544
Query: 689 SYDAQRNEW 697
YD + W
Sbjct: 545 KYDPISDTW 553
Score = 128 bits (321), Expect = 2e-29
Identities = 69/209 (33%), Positives = 108/209 (51%), Gaps = 7/209 (3%)
Query: 410 PERRSMMQSPRTKPRKSTVGA------LYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMN 463
P+ + R +ST+G LYA+GG D ++EKY + W + M
Sbjct: 361 PDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMT 420
Query: 464 GRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEG 523
R F AV+D +Y +GG G +N+VE ++P W ++ M+ R GV + G
Sbjct: 421 TTRSCFAAAVLDGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLG 479
Query: 524 PMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSC 583
++ VGGH+G S+L+++ER+DP QW M PR+ VG ++N LY +GG GSS
Sbjct: 480 FIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSY 539
Query: 584 LKSMEYFDPHTNKWSLCAPMSKRRGGVGV 612
L +++ +DP ++ W A M R G+
Sbjct: 540 LNTVQKYDPISDTWLDSAGMIYCRCNFGL 568
Score = 108 bits (270), Expect = 2e-23
Identities = 64/183 (34%), Positives = 96/183 (52%), Gaps = 9/183 (4%)
Query: 392 GDLECQKLLMEAMKYHLLPERRSMMQ-SPRTKPRKSTV-----GALYAVGGMDAMKGTTT 445
G + Q L KY +P+ R +P T R G +YA+GG +
Sbjct: 392 GGYDGQSYLQSVEKY--IPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGYGPAH-MNS 448
Query: 446 IEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTV 505
+E+YD +SW + +M +R+ FGV V+ ++VVGG +G+ L+++E ++P WTV
Sbjct: 449 VERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPHQNQWTV 508
Query: 506 MPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGV 565
PM R G+G A ++ +Y VGGH G SYLNTV+++DP W A M R G+
Sbjct: 509 CRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGMIYCRCNFGL 568
Query: 566 VAL 568
AL
Sbjct: 569 TAL 571
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 401 bits (1031), Expect = e-111
Identities = 221/561 (39%), Positives = 325/561 (57%), Gaps = 12/561 (2%)
Query: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEV 223
H ++ + M + LCDV ++A + I AHR+VL+A S YF AMFT ++ E++ + V
Sbjct: 42 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 101
Query: 224 RMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSN 283
R++ VD L L+ Y YT +Q+ E+ ++ LL AA LLQL V C FL QLHP N
Sbjct: 102 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 161
Query: 284 CLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEE 343
CLGIR+F D CT+LLN A+ Y +HF +V+ ++EFL L ++ L+ SD + + EE
Sbjct: 162 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 221
Query: 344 TIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLECQKLLME 402
+F A++ WV HD RQ + L+ ++RLPLLP + L +E ++ C+ L+E
Sbjct: 222 KVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIE 281
Query: 403 AMKYHLLP-ERRSMMQSPRTKPR-KSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIG 460
AMKYHLLP E+R +M+S RT+ R + L V G A K ++E YD + W +
Sbjct: 282 AMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVA 341
Query: 461 TMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVAT 520
+ RR + G+ + ++ VGG +G + TV+ ++PV WT + M R LG A
Sbjct: 342 ELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAV 401
Query: 521 LEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDG 580
L G +YAVGG DG + L++VE ++ + +W +VA M+T RS+VGV + LYA+GG DG
Sbjct: 402 LNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDG 461
Query: 581 SS--CLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSD 638
+S CL ++E ++ TN+W+ A MS RR G GV N LY VGGHD P +
Sbjct: 462 ASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL------VRK 515
Query: 639 CVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWK 698
VE YDP ++W VA +++ R VC + LYVVGG DG L +VE Y+ ++W
Sbjct: 516 SVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWT 575
Query: 699 -EEVPVNIGRAGACVVVVKLP 718
++ GR+ A V V+ P
Sbjct: 576 VVSSCMSTGRSYAGVTVIDKP 596
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 401 bits (1031), Expect = e-111
Identities = 221/561 (39%), Positives = 325/561 (57%), Gaps = 12/561 (2%)
Query: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEV 223
H ++ + M + LCDV ++A + I AHR+VL+A S YF AMFT ++ E++ + V
Sbjct: 38 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 97
Query: 224 RMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSN 283
R++ VD L L+ Y YT +Q+ E+ ++ LL AA LLQL V C FL QLHP N
Sbjct: 98 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 157
Query: 284 CLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEE 343
CLGIR+F D CT+LLN A+ Y +HF +V+ ++EFL L ++ L+ SD + + EE
Sbjct: 158 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 217
Query: 344 TIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLECQKLLME 402
+F A++ WV HD RQ + L+ ++RLPLLP + L +E ++ C+ L+E
Sbjct: 218 KVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIE 277
Query: 403 AMKYHLLP-ERRSMMQSPRTKPR-KSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIG 460
AMKYHLLP E+R +M+S RT+ R + L V G A K ++E YD + W +
Sbjct: 278 AMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVA 337
Query: 461 TMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVAT 520
+ RR + G+ + ++ VGG +G + TV+ ++PV WT + M R LG A
Sbjct: 338 ELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAV 397
Query: 521 LEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDG 580
L G +YAVGG DG + L++VE ++ + +W +VA M+T RS+VGV + LYA+GG DG
Sbjct: 398 LNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDG 457
Query: 581 SS--CLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSD 638
+S CL ++E ++ TN+W+ A MS RR G GV N LY VGGHD P +
Sbjct: 458 ASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL------VRK 511
Query: 639 CVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWK 698
VE YDP ++W VA +++ R VC + LYVVGG DG L +VE Y+ ++W
Sbjct: 512 SVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWT 571
Query: 699 -EEVPVNIGRAGACVVVVKLP 718
++ GR+ A V V+ P
Sbjct: 572 VVSSCMSTGRSYAGVTVIDKP 592
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 400 bits (1029), Expect = e-111
Identities = 216/547 (39%), Positives = 321/547 (58%), Gaps = 15/547 (2%)
Query: 175 YLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALN 234
+ + +LCDV L G I H+LVL+ V YF AMF +++ EAKQ + + D +A+
Sbjct: 60 FYENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIE 119
Query: 235 SLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQ 294
LV++ Y+ L L D ++ LL AAC+LQ+ V C ++ HPSNCL +R+F ++
Sbjct: 120 DLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESH 179
Query: 295 GCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVG 354
+L+++A +Y +HF EV++ ++F+ + + KLL S D+N+ +E+ +++A ++W+
Sbjct: 180 NRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLL 239
Query: 355 HDVQNRQGELGMLLSYIRLPLLPPQLLADLETSSMFTG-DLECQKLLMEAMKYHLLPERR 413
+ Q+ L L+ +RLPLLP L + +L+C+ LL EA YHL R
Sbjct: 240 ANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSR 299
Query: 414 SMMQ---SPRTKPRKSTVGALYAVGGMDAMKGT-TTIEKYDLRTNSWLHIGTMNGRRLQF 469
++ S RT PRK T G L+ VGG +IE Y + NSW MN RR
Sbjct: 300 AVPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHV 359
Query: 470 GVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVG 529
GV ++ K+Y VGG DG + L ++E F+P+ W + M+T R G+ +A+L GP+YA+G
Sbjct: 360 GVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIG 419
Query: 530 GHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEY 589
G D + N VER+D E QW+ VA M+TPR VG VAL N +YA+GG DG + L S+E
Sbjct: 420 GLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVER 479
Query: 590 FDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHD--APASNHCSRLSDCVERYDPKG 647
+DPH +KW M +RR G GV+ +G LYVVGG D +P S+ VERYDP+
Sbjct: 480 YDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSS--------VERYDPRS 531
Query: 648 DSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPVNIGR 707
+ W VA L+ PR V + + K++ VGG++G+ YLNTVE++D N W+ V+ R
Sbjct: 532 NKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCR 591
Query: 708 AGACVVV 714
AGA V V
Sbjct: 592 AGAGVAV 598
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 399 bits (1025), Expect = e-111
Identities = 212/559 (37%), Positives = 314/559 (56%), Gaps = 17/559 (3%)
Query: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEV 223
HA+ L M + K LCDV L PAHR+VL+A SDYF AMFT+++ E + V
Sbjct: 15 HAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYV 74
Query: 224 RMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSN 283
++G+ + + L+ + YT + + + ++ LL AACLLQL V C FL QL PSN
Sbjct: 75 DIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSN 134
Query: 284 CLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEE 343
CLGIR F + C +L+ A ++ +HF EV++++EF+LL E+ KL+ D+I V EE
Sbjct: 135 CLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEE 194
Query: 344 TIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLECQKLLME 402
+F A++ WV H + R+ L LL Y+R+PLL P+ + D ++ L+C+ L+ E
Sbjct: 195 PVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDE 254
Query: 403 AMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKG-TTTIEKYDLRTNSWLHIGT 461
A K+HL PE RS MQ PRT+ R L VGG + + +EKYD +T W + +
Sbjct: 255 AKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPS 314
Query: 462 MNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGK---IWTVMPPMSTHRHGLGV 518
+ +R + +++YV+GG DG L++VEC + +W + PM+ R G
Sbjct: 315 ITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGA 374
Query: 519 ATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGR 578
TL +Y GG DG ++ER+DP QW+ + M T R G+V + +Y +GG
Sbjct: 375 TTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGY 434
Query: 579 DGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSD 638
DG + L S+E +DPHT W+ PM+ +R G GVA N +YVVGG D A H S
Sbjct: 435 DGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTA--HLS---- 488
Query: 639 CVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWK 698
VE Y+ + DSW+TV ++ PR V L +LY + GYDG++ L+++E YD + W
Sbjct: 489 SVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSW- 547
Query: 699 EEVPVNIGR----AGACVV 713
EV ++G AG CV+
Sbjct: 548 -EVVTSMGTQRCDAGVCVL 565
Score = 123 bits (308), Expect = 7e-28
Identities = 68/195 (34%), Positives = 103/195 (52%), Gaps = 10/195 (5%)
Query: 525 MYAVGGHDGW-SYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSC 583
+ VGG S ++ VE++DP+ ++W+++ S++ R V V+L++++Y IGG DG S
Sbjct: 283 LLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSR 342
Query: 584 LKSMEYFDPHTNK---WSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCV 640
L S+E D ++ W APM+ RRG G T +YV GG D SR +
Sbjct: 343 LSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDG------SRRHTSM 396
Query: 641 ERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEE 700
ERYDP D WS + + R+ + +Y +GGYDG LN+VE YD W
Sbjct: 397 ERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLNILNSVEKYDPHTGHWTNV 456
Query: 701 VPVNIGRAGACVVVV 715
P+ R+GA V ++
Sbjct: 457 TPMATKRSGAGVALL 471
Score = 110 bits (274), Expect = 6e-24
Identities = 55/143 (38%), Positives = 81/143 (56%)
Query: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLK 488
G +Y +GG D + ++EKYD T W ++ M +R GVA++++ +YVVGG DG
Sbjct: 426 GVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTA 485
Query: 489 TLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGR 548
L++VE +N WT + M+T R +G L G +YA+ G+DG S L+++E +DP
Sbjct: 486 HLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIID 545
Query: 549 QWNYVASMSTPRSTVGVVALNNK 571
W V SM T R GV L K
Sbjct: 546 SWEVVTSMGTQRCDAGVCVLREK 568
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 397 bits (1020), Expect = e-110
Identities = 211/550 (38%), Positives = 310/550 (56%), Gaps = 10/550 (1%)
Query: 172 MENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPN 231
ME ++ +LCDV L G + AHR+VL+A YF AMFTND++E KQ+E+ M+G+DP+
Sbjct: 28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPS 87
Query: 232 ALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFG 291
AL +L+ +AY G L + + ++SLL A LQL + D C FL ++LHP NCLG+R F
Sbjct: 88 ALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFA 147
Query: 292 DAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQ 351
+ C L + A+ + +HF+EV ++EFL LP ++ +L+ D++NV EE +F A +
Sbjct: 148 ETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALA 207
Query: 352 WVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLECQKLLMEAMKYHLLP 410
WV +D + R L LLS IRLPL PQ L+D ++ + +C+ L+ EA YHL+P
Sbjct: 208 WVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMP 267
Query: 411 ERRSMMQSPRTKPR--KSTVGALYAVGGMD-AMKGTTTIEKYDLRTNSWLHIGTMNGRRL 467
ERR + + RT+PR S G +YAVGG++ A +E +D N W M R
Sbjct: 268 ERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARS 327
Query: 468 QFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYA 527
+ GVAV++ LY +GG DG L+TVE +NP WT + M++ R +G L+G +Y
Sbjct: 328 RVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYV 387
Query: 528 VGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSM 587
GG+DG S L++VE + PE +W V SMS+ RS GV ++Y GG DG S+
Sbjct: 388 CGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSV 447
Query: 588 EYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKG 647
E+++ HT W A M +R G A+ ++V GG+D S E Y
Sbjct: 448 EHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDG------SGFLSIAEMYSSVA 501
Query: 648 DSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPVNIGR 707
D W + P+ R V++ +LY VGGYDG + L++VE YD + + W P+
Sbjct: 502 DQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPMACHE 561
Query: 708 AGACVVVVKL 717
G V + L
Sbjct: 562 GGVGVGCIPL 571
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 359 bits (922), Expect = 4e-99
Identities = 200/508 (39%), Positives = 293/508 (57%), Gaps = 12/508 (2%)
Query: 217 EAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLI 276
E++ + VR++ VD L L+ Y YT +Q+ E+ ++ LL AA LLQL V C FL
Sbjct: 3 ESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLE 62
Query: 277 KQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDD 336
QLHP NCLGIR+F D CT+LLN A+ Y +HF +V+ ++EFL L ++ L+ SD
Sbjct: 63 SQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDK 122
Query: 337 INVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLE 395
+ + EE +F A++ WV HD RQ + L+ ++RLPLLP + L +E ++
Sbjct: 123 LTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSA 182
Query: 396 CQKLLMEAMKYHLLP-ERRSMMQSPRTKPR-KSTVGALYAVGGMDAMKGTTTIEKYDLRT 453
C+ L+EAMKYHLLP E+R +M+S RT+ R + L V G A K ++E YD +
Sbjct: 183 CKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKE 242
Query: 454 NSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHR 513
W + + RR + G+ + ++ VGG +G + TV+ ++PV WT + M R
Sbjct: 243 ERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRR 302
Query: 514 HGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLY 573
LG A L G +YAVGG DG + L++VE ++ + +W +VA M+T RS+VGV + LY
Sbjct: 303 STLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLY 362
Query: 574 AIGGRDGSS--CLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASN 631
A+GG DG+S CL ++E ++ TN+W+ A MS RR G GV N LY VGGHD P
Sbjct: 363 AVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL-- 420
Query: 632 HCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYD 691
+ VE YDP ++W VA +++ R VC + LYVVGG DG L +VE Y+
Sbjct: 421 ----VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYN 476
Query: 692 AQRNEWK-EEVPVNIGRAGACVVVVKLP 718
++W ++ GR+ A V V+ P
Sbjct: 477 PTTDKWTVVSSCMSTGRSYAGVTVIDKP 504
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 342 bits (878), Expect = 5e-94
Identities = 203/609 (33%), Positives = 312/609 (51%), Gaps = 29/609 (4%)
Query: 120 CEKRAQDLEMMADDNIEDSTARLDTQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEK 179
C + A D M A + + + S+ N T S + + +H +Q M +
Sbjct: 23 CPEGAGDAVMYAS-----TECKAEVTPSQHGNRTFS---YTLEDHTKQAFGIMNELRLSQ 74
Query: 180 QLCDVLLIAGHLRIPA-----HRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALN 234
QLCDV L + PA H++VL++ S F AMFTN + E E V +EG+ P +
Sbjct: 75 QLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVME 134
Query: 235 SLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQ 294
L+++AYT + + E + ++ A + Q+ V+ CS+FL++QL PSN +GI +F +
Sbjct: 135 RLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQI 194
Query: 295 GCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVG 354
GC EL A +Y HF EV K +EF L ++ L+ DD+NV E +FHA + WV
Sbjct: 195 GCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVK 254
Query: 355 HDVQNRQGELGMLLSYIRLPLLPPQLL-ADLETSSMFTGDLECQKLLMEAMKYHLLPERR 413
+D + R+ + LL +R L P L L+ + D C+ L++ + L +
Sbjct: 255 YDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKIFEELTLHKPT 314
Query: 414 SMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAV 473
+M R VG L G + + +E Y+ +WL + + R V
Sbjct: 315 QVMPC-----RAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCV 369
Query: 474 IDNKLYVVGGR----DGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVG 529
+ LY VGGR DG + ++C+NP+ W+ PMS R+ +GV ++G +YAVG
Sbjct: 370 VGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVG 429
Query: 530 GHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEY 589
G G + N+VER++PE +W+ VA M T R VGV LN LYA+GG DG++ L S E
Sbjct: 430 GSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAEC 489
Query: 590 FDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDS 649
+ P N+W + M+ R G GV + +Y GG+D + VERYD + ++
Sbjct: 490 YYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQ------LNSVERYDVETET 543
Query: 650 WSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAG 709
W+ VAP+ R A+ + ++YV+GGYDGHT+L++VE YD + W E + GR+G
Sbjct: 544 WTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSG 603
Query: 710 ACVVVVKLP 718
V V P
Sbjct: 604 VGVAVTMEP 612
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 342 bits (878), Expect = 5e-94
Identities = 203/609 (33%), Positives = 312/609 (51%), Gaps = 29/609 (4%)
Query: 120 CEKRAQDLEMMADDNIEDSTARLDTQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEK 179
C + A D M A + + + S+ N T S + + +H +Q M +
Sbjct: 23 CPEGAGDAVMYAS-----TECKAEVTPSQHGNRTFS---YTLEDHTKQAFGIMNELRLSQ 74
Query: 180 QLCDVLLIAGHLRIPA-----HRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALN 234
QLCDV L + PA H++VL++ S F AMFTN + E E V +EG+ P +
Sbjct: 75 QLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVME 134
Query: 235 SLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQ 294
L+++AYT + + E + ++ A + Q+ V+ CS+FL++QL PSN +GI +F +
Sbjct: 135 RLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQI 194
Query: 295 GCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVG 354
GC EL A +Y HF EV K +EF L ++ L+ DD+NV E +FHA + WV
Sbjct: 195 GCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVK 254
Query: 355 HDVQNRQGELGMLLSYIRLPLLPPQLL-ADLETSSMFTGDLECQKLLMEAMKYHLLPERR 413
+D + R+ + LL +R L P L L+ + D C+ L++ + L +
Sbjct: 255 YDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKIFEELTLHKPT 314
Query: 414 SMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAV 473
+M R VG L G + + +E Y+ +WL + + R V
Sbjct: 315 QVMPC-----RAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCV 369
Query: 474 IDNKLYVVGGR----DGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVG 529
+ LY VGGR DG + ++C+NP+ W+ PMS R+ +GV ++G +YAVG
Sbjct: 370 VGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVG 429
Query: 530 GHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEY 589
G G + N+VER++PE +W+ VA M T R VGV LN LYA+GG DG++ L S E
Sbjct: 430 GSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAEC 489
Query: 590 FDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDS 649
+ P N+W + M+ R G GV + +Y GG+D + VERYD + ++
Sbjct: 490 YYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQ------LNSVERYDVETET 543
Query: 650 WSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAG 709
W+ VAP+ R A+ + ++YV+GGYDGHT+L++VE YD + W E + GR+G
Sbjct: 544 WTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSG 603
Query: 710 ACVVVVKLP 718
V V P
Sbjct: 604 VGVAVTMEP 612
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 325 bits (832), Expect = 1e-88
Identities = 185/579 (31%), Positives = 308/579 (53%), Gaps = 21/579 (3%)
Query: 149 DMNATRSEEQFHVINHAEQTLRKME----NYLK-EKQLCDVLLIAGHLRIPAHRLVLSAV 203
+M + + +FH H E+ + M N L+ E +LCDV++ AH+ +L +
Sbjct: 2 EMESAAASTRFHQ-PHMERKMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSC 60
Query: 204 SDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQ 263
S YF A+FT+ +++ + G+ P+ + +++YAYT + + D +E LLAAA
Sbjct: 61 SSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFN 120
Query: 264 LTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIK-NQEFLL 322
+ ++ C FL +L NC+GI F D C EL A+ + + +F E++K + EFL
Sbjct: 121 IMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLE 180
Query: 323 LPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LL 381
L E+ ++ D++NV E+ +F A+++W+ HD QNR+ + +LL +RL L+ + +
Sbjct: 181 LSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFM 240
Query: 382 ADLETSSMFTGDLECQKLLMEAMK----YHLLPERRSMMQSPRTKPRKSTVGALYAVGGM 437
+++ + EC+ +++ A+K ++ S +P T+PR L+A+GG
Sbjct: 241 NNVKMNDYVKDSEECKPVIINALKAMYDLNMNGPSNSDFTNPLTRPRLP-YAILFAIGGW 299
Query: 438 DAMKGTTTIEKYDLRTNSWLHIGTMN-GRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECF 496
T IE YD R + W+++ R G A + +Y++GG D + N+V+ F
Sbjct: 300 SGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRF 359
Query: 497 NPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASM 556
+PV K W + PM + R + V L +YA+GG DG+ LNT ER++PE QW +A M
Sbjct: 360 DPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPM 419
Query: 557 STPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYN 616
RS L K+Y GG +G+ CL + E ++ +N+W++ APM RR G+GV Y
Sbjct: 420 HEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYG 479
Query: 617 GFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVG 676
+Y VGG D +RL E Y P ++W T+ + PR + + D L+VVG
Sbjct: 480 EHVYAVGGFDG-----ANRLRS-AEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVG 533
Query: 677 GYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAG-ACVVV 714
G++G T VE YD + +EW + ++I R+ +C VV
Sbjct: 534 GFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVV 572
Score = 45.4 bits (106), Expect = 2e-04
Identities = 25/98 (25%), Positives = 44/98 (44%), Gaps = 7/98 (7%)
Query: 619 LYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVA-PLSVPRDAVAVCPLGDKLYVVGG 677
L+ +GG + ++ +E YD + D W V PR L +Y++GG
Sbjct: 293 LFAIGGWSGGSP------TNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGG 346
Query: 678 YDGHTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVVV 715
+D Y N+V+ +D + W + P++ R V V+
Sbjct: 347 FDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVL 384
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 322 bits (825), Expect = 8e-88
Identities = 189/564 (33%), Positives = 293/564 (51%), Gaps = 24/564 (4%)
Query: 155 SEEQFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTND 214
++ F HA+ L ++ + CDV L G AHRLVL+A S YFAA+FT
Sbjct: 10 ADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGG 69
Query: 215 VLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNF 274
+ E+ ++ V + G++ L+ + YTG++ + + ++ L+ AA +LQLT+V+ +C F
Sbjct: 70 MKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEF 129
Query: 275 LIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCS 334
L Q+ P NC+GI F + C +LL + Y HF+EV +EFL L +++ K+L S
Sbjct: 130 LKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRS 189
Query: 335 DDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LLADLETSSMFTGD 393
+++++ DE +F A MQW+ D+ R+ + +L IR PLLPPQ LL +E S F
Sbjct: 190 EELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLR 249
Query: 394 LECQKLLMEAMKYHLLPERR---SMMQSPRTKPRKSTVGALYAVGGMDAMKG-------- 442
+ Q LL E + P+ S +Q+ + +PRK LYAVGG ++G
Sbjct: 250 VALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRA 309
Query: 443 TTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKI 502
+ +E++D + W + +++ R GV V+ +Y +GG + EC++PV K
Sbjct: 310 LSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQ 369
Query: 503 WTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRST 562
WT + M+ R GLGV G +YA+GG G NT+ER+DP+ +W V +M+ R
Sbjct: 370 WTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYY 429
Query: 563 VGVVALNNKLYAIGGRDGSSC-LKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYV 621
G + +Y IGG L+S E +DP + +WS PM RR +GVA N +Y
Sbjct: 430 FGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYS 489
Query: 622 VGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGG-YDG 680
VGG N VE+Y + + W VA + VPR + V + LYV GG
Sbjct: 490 VGGW-----NETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSS 544
Query: 681 HTY-----LNTVESYDAQRNEWKE 699
H + L++VE Y+ + W E
Sbjct: 545 HDFLAPGTLDSVEVYNPHSDTWTE 568
Score = 124 bits (312), Expect = 2e-28
Identities = 75/195 (38%), Positives = 111/195 (56%), Gaps = 12/195 (6%)
Query: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGG--RDG 486
GA+YA+GG + TIE++D N W +G M R FG + +YV+GG +G
Sbjct: 390 GAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEG 449
Query: 487 LKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGG-HDGWSYLNTVERWDP 545
++ L + E ++P+ K W+ +PPM T R LGVA L +Y+VGG ++ L+TVE++
Sbjct: 450 IE-LRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSF 508
Query: 546 EGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGS------SCLKSMEYFDPHTNKWSL 599
E +W VASM PR+ + VVA+N LY GGR S L S+E ++PH++ W+
Sbjct: 509 EEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTE 568
Query: 600 CAPM--SKRRGGVGV 612
M S+ GGV V
Sbjct: 569 IGNMITSRCEGGVAV 583
Score = 55.5 bits (132), Expect = 2e-07
Identities = 32/99 (32%), Positives = 43/99 (43%), Gaps = 2/99 (2%)
Query: 618 FLYVVGGHDAPASNHCS--RLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVV 675
+LY VGG+ S R CVER+D W+TV+ L R + V LG +Y +
Sbjct: 289 YLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAI 348
Query: 676 GGYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVV 714
GG + E YD +W +N R G V V
Sbjct: 349 GGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCV 387
Score = 53.9 bits (128), Expect = 5e-07
Identities = 33/98 (33%), Positives = 47/98 (47%), Gaps = 7/98 (7%)
Query: 431 LYAVGGMDAMKGTT-TIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLK- 488
+Y+VGG + + T+EKY W+ + +M R V ++ LYV GGR
Sbjct: 487 IYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHD 546
Query: 489 -----TLNTVECFNPVGKIWTVMPPMSTHRHGLGVATL 521
TL++VE +NP WT + M T R GVA L
Sbjct: 547 FLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAVL 584
>gi|223890235 intracisternal A particle-promoted polypeptide isoform
2 [Homo sapiens]
Length = 582
Score = 318 bits (816), Expect = 8e-87
Identities = 187/559 (33%), Positives = 290/559 (51%), Gaps = 20/559 (3%)
Query: 155 SEEQFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTND 214
++ F HA+ L ++ + CDV L G AHRLVL+A S YFAA+FT
Sbjct: 10 ADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGG 69
Query: 215 VLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNF 274
+ E+ ++ V + G++ L+ + YTG++ + + ++ L+ AA +LQLT+V+ +C F
Sbjct: 70 MKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEF 129
Query: 275 LIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCS 334
L Q+ P NC+GI F + C +LL + Y HF+EV +EFL L +++ K+L S
Sbjct: 130 LKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRS 189
Query: 335 DDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LLADLETSSMFTGD 393
+++++ DE +F A MQW+ D+ R+ + +L IR PLLPPQ LL +E S F
Sbjct: 190 EELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLR 249
Query: 394 LECQKLLMEAMKYHLLPERR---SMMQSPRTKPRKSTVGALYAVGGMDAMKG-------- 442
+ Q LL E + P+ S +Q+ + +PRK LYAVGG ++G
Sbjct: 250 VALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRA 309
Query: 443 TTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKI 502
+ +E++D + W + +++ R GV V+ +Y +GG + EC++PV K
Sbjct: 310 LSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQ 369
Query: 503 WTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRST 562
WT + M+ R GLGV G +YA+GG G NT+ER+DP+ +W V +M+ R
Sbjct: 370 WTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYY 429
Query: 563 VGVVALNNKLYAIGGRDGSSC-LKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYV 621
G + +Y IGG L+S E +DP + +WS PM RR +GVA N +Y
Sbjct: 430 FGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYS 489
Query: 622 VGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGG-YDG 680
VGG N VE+Y + + W VA + VPR + V + LYV GG
Sbjct: 490 VGGW-----NETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSS 544
Query: 681 HTYL-NTVESYDAQRNEWK 698
H +L Y+ R +W+
Sbjct: 545 HDFLAPDTHRYEVFRLKWE 563
Score = 55.5 bits (132), Expect = 2e-07
Identities = 32/99 (32%), Positives = 43/99 (43%), Gaps = 2/99 (2%)
Query: 618 FLYVVGGHDAPASNHCS--RLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVV 675
+LY VGG+ S R CVER+D W+TV+ L R + V LG +Y +
Sbjct: 289 YLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAI 348
Query: 676 GGYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVV 714
GG + E YD +W +N R G V V
Sbjct: 349 GGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCV 387
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 273 bits (698), Expect = 4e-73
Identities = 175/569 (30%), Positives = 280/569 (49%), Gaps = 17/569 (2%)
Query: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHL--RIPAHRLVLSAVSDYFAAMFTNDVLEAKQE 221
H+ L+ + E LCDV L+ G P HR+++++ SDYF AMFT + E
Sbjct: 74 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLM 133
Query: 222 EVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHP 281
+++ GV L ++ + YT L L D ++ L AA LQ+ V+D C FLI +
Sbjct: 134 CIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTL 193
Query: 282 SNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPD 341
NC+ + + TE+ + + +++F ++ EFL LP ++ +L S+ +
Sbjct: 194 DNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCT 253
Query: 342 EETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LLADLETSSMFTGDLECQKLL 400
E +F A +W+ + + R L+ IR PL+ PQ L+ ++T D C LL
Sbjct: 254 ELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLL 312
Query: 401 MEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGM--DAMKGTTTIEKYDLRTNSWLH 458
+EA Y ++P + +MQS RT R T L +GG+ + + + YD + + W
Sbjct: 313 LEASNYQMMPYMQPVMQSDRTAIRSDTT-HLVTLGGVLRQQLVVSKELRMYDEKAHEWKS 371
Query: 459 IGTMNGRRLQFGVAVIDNKLYVVGGRD-----GLKTLNTVECFNPVGKIWTVMPPMSTHR 513
+ M+ R Q G+AVI N LYVVGG+ G ++TV F+P W + ++ R
Sbjct: 372 LAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKR 431
Query: 514 HGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLY 573
++ L+G +YAVGG + L TVE ++P +W YVA MS P +Y
Sbjct: 432 TFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMY 491
Query: 574 AIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHC 633
GG + K + FDP T+KW APM+ RG + T LYV+GG+ ++
Sbjct: 492 ISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDY 551
Query: 634 SRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGY--DGHTYLNTVESYD 691
+ C E Y P D W+ +A + + V V +K+YVVGGY + + V+ YD
Sbjct: 552 DDVLSC-EYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYD 610
Query: 692 AQRNEWKE--EVPVNIGRAGACVVVVKLP 718
++EW + ++P ++G AC + V P
Sbjct: 611 PDKDEWHKVFDLPESLGGIRACTLTVFPP 639
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 268 bits (686), Expect = 1e-71
Identities = 173/569 (30%), Positives = 277/569 (48%), Gaps = 17/569 (2%)
Query: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLR--IPAHRLVLSAVSDYFAAMFTNDVLEAKQE 221
H+ L+ + E LCDV L+ G P HR ++++ SDYF AMFT + E
Sbjct: 32 HSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDLM 91
Query: 222 EVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHP 281
+++ GV+ L ++ + YT L L D ++ L AA LQ+ V+D C FLI +
Sbjct: 92 CIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVSL 151
Query: 282 SNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPD 341
NC+ + + E+ + + +++F ++ EFL LP ++ +L S+ +
Sbjct: 152 DNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCT 211
Query: 342 EETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LLADLETSSMFTGDLECQKLL 400
E +F A +W+ + R L+ IR PL+ PQ L+ ++T D C LL
Sbjct: 212 ELELFKAACRWLRLE-DPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLL 270
Query: 401 MEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGM--DAMKGTTTIEKYDLRTNSWLH 458
+EA Y ++P + +MQS RT R + L +GG+ + + + YD R W
Sbjct: 271 LEASNYQMMPYMQPVMQSDRTAIRSDST-HLVTLGGVLRQQLVVSKELRMYDERAQEWRS 329
Query: 459 IGTMNGRRLQFGVAVIDNKLYVVGGRD-----GLKTLNTVECFNPVGKIWTVMPPMSTHR 513
+ M+ R Q G+AVI N LYVVGG+ G ++TV F+P W + ++ R
Sbjct: 330 LAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKR 389
Query: 514 HGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLY 573
++ L+G +YAVGG L TVE ++P +W+YVA MS P +Y
Sbjct: 390 TFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMY 449
Query: 574 AIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHC 633
GG + + FDP T+KW APM+ RG + T LYV+GG+ ++
Sbjct: 450 ISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDY 509
Query: 634 SRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGY--DGHTYLNTVESYD 691
+ C E Y P D W+ +A + + V V +K+YVVGGY + + V+ YD
Sbjct: 510 DDVLSC-EYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYD 568
Query: 692 AQRNEWKE--EVPVNIGRAGACVVVVKLP 718
+++EW + ++P ++G AC + V P
Sbjct: 569 PEKDEWHKVFDLPESLGGIRACTLTVFPP 597
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 265 bits (678), Expect = 8e-71
Identities = 168/551 (30%), Positives = 267/551 (48%), Gaps = 18/551 (3%)
Query: 172 MENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPN 231
M N K+K LCDV+L+ +IPAHR+VL+A S +F MFT ++LE+K EV ++ +P+
Sbjct: 34 MNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPD 93
Query: 232 ALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFG 291
+ LV++AYT + + + ++SLL AA Q+ V +C +FL +Q+ SNCLGI
Sbjct: 94 IIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLA 153
Query: 292 DAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQ 351
+ C EL A + +HF EV K EFL L ++ LL D + V E+ ++ A ++
Sbjct: 154 ECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVR 213
Query: 352 WVGHDVQNRQGELGMLLSYIRLPLLPPQLLA-DLETSSMFTGDLECQKLLMEAMKYHLL- 409
W+ +D NRQ + +L+ +R PL+ L+ ++ + + EC K+++ M+YHLL
Sbjct: 214 WLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLS 273
Query: 410 PERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQF 469
PE R + RK + GG + ++ + SW I +R
Sbjct: 274 PEDREELVDGTRPRRKKHDYRIALFGGSQPQ----SCRYFNPKDYSWTDIRCPFEKRRDA 329
Query: 470 GVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVG 529
DN +Y++GG L + ++C+N V W T R L EG +Y G
Sbjct: 330 ACVFWDNVVYILGGSQ-LFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSG 388
Query: 530 GHD-GWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSS----CL 584
G + G S L E +D W+ SM T R + G+V N +Y GG G++ L
Sbjct: 389 GSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVL 448
Query: 585 KSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYD 644
S E +DP T W+ PM + R G+ ++ VGG + D VE YD
Sbjct: 449 NSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGG------LDNVEYYD 502
Query: 645 PKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPVN 704
K + W V+P+ V +G +YV+ G+ G L + Y+ + ++W V
Sbjct: 503 IKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVR 562
Query: 705 IGRAGACVVVV 715
+C++ V
Sbjct: 563 AFPVTSCLICV 573
Score = 49.7 bits (117), Expect = 1e-05
Identities = 44/188 (23%), Positives = 71/188 (37%), Gaps = 10/188 (5%)
Query: 533 GWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDP 592
G S + ++P+ W + R V +N +Y +GG +K M+ ++
Sbjct: 299 GGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFP-IKRMDCYNV 357
Query: 593 HTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWST 652
+ W R + G +Y GG + N L +C YD + +SW T
Sbjct: 358 VKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEV--GNSALYLFEC---YDTRTESWHT 412
Query: 653 VAPLSVPRDAVAVCPLGDKLYVVGGYDGHTY----LNTVESYDAQRNEWKEEVPVNIGRA 708
+ R + + +YV GG G+ LN+ E YD W E P+ R
Sbjct: 413 KPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARK 472
Query: 709 GACVVVVK 716
+V VK
Sbjct: 473 NHGLVFVK 480
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 265 bits (678), Expect = 8e-71
Identities = 163/522 (31%), Positives = 262/522 (50%), Gaps = 24/522 (4%)
Query: 163 NHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEE 222
+HAE L+ + + DV++ P HR VLSA S YF AMF ND E+++
Sbjct: 47 SHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREML 106
Query: 223 VRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPS 282
V + G+ A+ +QY YTG +++ + ++ L + L Q++ + D C+ FL +QL P
Sbjct: 107 VEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPC 166
Query: 283 NCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDE 342
NCLGI+ F D L + ++ F +V +++EFL L +E+ +CSD++ + E
Sbjct: 167 NCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKE 226
Query: 343 ETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LLADLETSSMFTGDLECQKLLM 401
E +F A+M+WV V R+ L LL+++RLPLL P + +E + EC +LL
Sbjct: 227 EMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLH 286
Query: 402 EAMKYHLLPERRSMMQSPRTKPRKST--VGALYAVGGMDAMKGTTT--IEKYDLRTNSWL 457
EA +YH+L M SPRT+PR+ST + VGG + + G E YD T W
Sbjct: 287 EARRYHILGNE---MMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWK 343
Query: 458 HIGTM-NGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGL 516
+ + + ++ V + N + V GGR + V +N IW + ++ R
Sbjct: 344 SLAKLPEFTKSEYAVCALRNDILVSGGRINSR---DVWIYNSQLNIWIRVASLNKGRWRH 400
Query: 517 GVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAI- 575
+A L G +Y VGG+DG + L++VE +D +W VA + S+ V + KL+ I
Sbjct: 401 KMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIG 460
Query: 576 GGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSR 635
GG D ++C ++ +DP TN W L A + + + + N +YV GG
Sbjct: 461 GGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGG----------- 509
Query: 636 LSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGG 677
L+ + YDP D W V ++ + K+Y++GG
Sbjct: 510 LTKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGG 551
Score = 79.3 bits (194), Expect = 1e-14
Identities = 69/218 (31%), Positives = 100/218 (45%), Gaps = 20/218 (9%)
Query: 505 VMPPMSTHRHGLG---VATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMST-PR 560
+M P + R G V + G VGG + L E +DP +W +A + +
Sbjct: 298 MMSPRTRPRRSTGYSEVIVVVGGCERVGGFN----LPYTECYDPVTGEWKSLAKLPEFTK 353
Query: 561 STVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLY 620
S V AL N + GGR S + + ++ N W A ++K R +A G +Y
Sbjct: 354 SEYAVCALRNDILVSGGRINS---RDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVY 410
Query: 621 VVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGY-D 679
VVGG+D +RLS VE YD + W+ VAPL + AV KL+V+GG D
Sbjct: 411 VVGGYDGQ-----NRLSS-VECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPD 464
Query: 680 GHTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVVVKL 717
+T + V+SYD + N W + I A C+ V L
Sbjct: 465 DNTCSDKVQSYDPETNSWLLRAAIPI--AKRCITAVSL 500
Score = 55.5 bits (132), Expect = 2e-07
Identities = 51/189 (26%), Positives = 80/189 (42%), Gaps = 17/189 (8%)
Query: 518 VATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGG 577
V T+E + + L+ R+ G + ++ + PR + G + + +GG
Sbjct: 266 VQTVEVDQLIQNSPECYQLLHEARRYHILGNEM--MSPRTRPRRSTGY---SEVIVVVGG 320
Query: 578 --RDGSSCLKSMEYFDPHTNKWSLCAPMSK-RRGGVGVATYNGFLYVVGGHDAPASNHCS 634
R G L E +DP T +W A + + + V + V GG
Sbjct: 321 CERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRIN------- 373
Query: 635 RLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQR 694
S V Y+ + + W VA L+ R + L K+YVVGGYDG L++VE YD+
Sbjct: 374 --SRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFS 431
Query: 695 NEWKEEVPV 703
N W E P+
Sbjct: 432 NRWTEVAPL 440
Score = 43.5 bits (101), Expect = 7e-04
Identities = 27/87 (31%), Positives = 46/87 (52%), Gaps = 10/87 (11%)
Query: 431 LYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGG-RDGLKT 489
+Y GG+ T I YD + W+H+ R+ G++V + K+Y++GG R+ +
Sbjct: 504 IYVAGGL-----TKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEA 558
Query: 490 LNTVECFNPVGKIWT---VMP-PMSTH 512
+T+ C++P I T MP P+S H
Sbjct: 559 TDTILCYDPATSIITGVAAMPRPVSYH 585
>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
Length = 564
Score = 260 bits (664), Expect = 4e-69
Identities = 165/545 (30%), Positives = 264/545 (48%), Gaps = 18/545 (3%)
Query: 178 EKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLV 237
+K LCDV+L+ +IPAHR+VL+A S +F MFT ++LE+K EV ++ +P+ + LV
Sbjct: 18 KKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLV 77
Query: 238 QYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCT 297
++AYT + + + ++SLL AA Q+ V +C +FL +Q+ SNCLGI + C
Sbjct: 78 EFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCP 137
Query: 298 ELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDV 357
EL A + +HF EV K EFL L ++ LL D + V E+ ++ A ++W+ +D
Sbjct: 138 ELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDE 197
Query: 358 QNRQGELGMLLSYIRLPLLPPQLLA-DLETSSMFTGDLECQKLLMEAMKYHLL-PERRSM 415
NRQ + +L+ +R PL+ L+ ++ + + EC K+++ M+YHLL PE R
Sbjct: 198 PNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREE 257
Query: 416 MQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVID 475
+ RK + GG + ++ + SW I +R D
Sbjct: 258 LVDGTRPRRKKHDYRIALFGGSQPQ----SCRYFNPKDYSWTDIRCPFEKRRDAACVFWD 313
Query: 476 NKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHD-GW 534
N +Y++GG L + ++C+N V W T R L EG +Y GG + G
Sbjct: 314 NVVYILGGSQ-LFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGN 372
Query: 535 SYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSS----CLKSMEYF 590
S L E +D W+ SM T R + G+V N +Y GG G++ L S E +
Sbjct: 373 SALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVY 432
Query: 591 DPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSW 650
DP T W+ PM + R G+ ++ VGG + D VE YD K + W
Sbjct: 433 DPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGG------LDNVEYYDIKLNEW 486
Query: 651 STVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAGA 710
V+P+ V +G +YV+ G+ G L + Y+ + ++W V +
Sbjct: 487 KMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVRAFPVTS 546
Query: 711 CVVVV 715
C++ V
Sbjct: 547 CLICV 551
Score = 49.7 bits (117), Expect = 1e-05
Identities = 44/188 (23%), Positives = 71/188 (37%), Gaps = 10/188 (5%)
Query: 533 GWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDP 592
G S + ++P+ W + R V +N +Y +GG +K M+ ++
Sbjct: 277 GGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFP-IKRMDCYNV 335
Query: 593 HTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWST 652
+ W R + G +Y GG + N L +C YD + +SW T
Sbjct: 336 VKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEV--GNSALYLFEC---YDTRTESWHT 390
Query: 653 VAPLSVPRDAVAVCPLGDKLYVVGGYDGHTY----LNTVESYDAQRNEWKEEVPVNIGRA 708
+ R + + +YV GG G+ LN+ E YD W E P+ R
Sbjct: 391 KPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARK 450
Query: 709 GACVVVVK 716
+V VK
Sbjct: 451 NHGLVFVK 458
>gi|24475847 influenza virus NS1A binding protein [Homo sapiens]
Length = 642
Score = 251 bits (640), Expect = 2e-66
Identities = 173/601 (28%), Positives = 284/601 (47%), Gaps = 57/601 (9%)
Query: 163 NHAEQTLRKMENYLKEKQLCDVLL-IAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQE 221
N E ++ K+ K Q CDV L + GH + AHR VL+ S Y +F +D
Sbjct: 13 NFIESSVAKLNALRKSGQFCDVRLQVCGHEML-AHRAVLACCSPYLFEIFNSDSDPHGIS 71
Query: 222 EVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHP 281
V+ + ++P A+ L+ YAYT L+ ++ ++ + +AA L++ +V VC ++L+ ++
Sbjct: 72 HVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDV 131
Query: 282 SNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPD 341
++C+ R+F G + LLN Y EH +++ + +EFL LP ++ +L D++ +P
Sbjct: 132 TSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVML-EDNVCLPS 190
Query: 342 EETIFHALMQWVGHDVQNRQGELGMLLSYIR----------------------------- 372
++ ++ WV + L L+ ++
Sbjct: 191 NGKLYTKVINWVQRSIWENGDSLEELMEEVQTLYYSADHKLLDGNLLDGQAEVFGSDDDH 250
Query: 373 ---LPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPRTKPRKSTVG 429
+ PP+ + SS TG L +++ K H S S T + +
Sbjct: 251 IQFVQKKPPRENGHKQISSSSTGCLSSPNATVQSPK-HEWKIVASEKTSNNTYLCLAVLD 309
Query: 430 ALYAV----GGMDAMKGTTTIEK------YDLRTNSWLH--IGTMNGRRLQFGVAVIDNK 477
++ V G T+ K ++++ + + + M R G A ++ K
Sbjct: 310 GIFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSGLGTAEMNGK 369
Query: 478 LYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSY- 536
L GG + + L TVEC+NP W+ + PM T R +A L G +Y VGG +G S
Sbjct: 370 LIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDD 429
Query: 537 LNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRD--GSSCLKSMEYFDPHT 594
L+ E +D W V + T R GV ALN KLY +GG D G LK+ + FDP T
Sbjct: 430 LSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVT 489
Query: 595 NKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVA 654
W+ CAP++ RR V G+LY++GG + S +C + VERY+P+ ++W+ +A
Sbjct: 490 KLWTSCAPLNIRRHQSAVCELGGYLYIIGGAE---SWNCL---NTVERYNPENNTWTLIA 543
Query: 655 PLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVV 714
P++V R V L KL+V GG+DG ++ VE YD RNEWK + R+ A +
Sbjct: 544 PMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIAT 603
Query: 715 V 715
V
Sbjct: 604 V 604
Score = 182 bits (463), Expect = 7e-46
Identities = 106/305 (34%), Positives = 158/305 (51%), Gaps = 10/305 (3%)
Query: 397 QKLLMEAMKYHLLPERRSMMQSPRTKPRKSTV-GALYAVGGMDAMKGTTTIEKYDLRTNS 455
+ L E + L+ + S MQ R+ + + G L A GG + + T+E Y+ T+
Sbjct: 335 KSLSFEMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDH 394
Query: 456 WLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKT-LNTVECFNPVGKIWTVMPPMSTHRH 514
W + M R +F +AV+ +LYVVGG +G L+ E ++ W +P + T+R
Sbjct: 395 WSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRC 454
Query: 515 GLGVATLEGPMYAVGGHD--GWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKL 572
GV L G +Y VGG D G L + +DP + W A ++ R V L L
Sbjct: 455 NAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYL 514
Query: 573 YAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNH 632
Y IGG + +CL ++E ++P N W+L APM+ R G GVA NG L+V GG D
Sbjct: 515 YIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDG----- 569
Query: 633 CSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDA 692
S CVE YDP + W + ++ PR + +G+ +Y VGG+DG+ +LNTVE Y+
Sbjct: 570 -SHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNL 628
Query: 693 QRNEW 697
+ NEW
Sbjct: 629 ESNEW 633
Score = 164 bits (416), Expect = 2e-40
Identities = 85/240 (35%), Positives = 127/240 (52%), Gaps = 10/240 (4%)
Query: 416 MQSPRTKPRKSTV-GALYAVGGMDAMKGTTTI-EKYDLRTNSWLHIGTMNGRRLQFGVAV 473
M++PR + + + + G LY VGG + + E YD + W+ + + R GV
Sbjct: 401 MRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCA 460
Query: 474 IDNKLYVVGGRD--GLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGH 531
++ KLY+VGG D G K L + F+PV K+WT P++ RH V L G +Y +GG
Sbjct: 461 LNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGA 520
Query: 532 DGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFD 591
+ W+ LNTVER++PE W +A M+ R GV LN KL+ GG DGS + +E +D
Sbjct: 521 ESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYD 580
Query: 592 PHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWS 651
P N+W + M+ R G+AT +Y VGG D + + VE Y+ + + WS
Sbjct: 581 PTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDG------NEFLNTVEVYNLESNEWS 634
>gi|8922854 kelch-like 26 [Homo sapiens]
Length = 615
Score = 249 bits (637), Expect = 5e-66
Identities = 170/578 (29%), Positives = 271/578 (46%), Gaps = 26/578 (4%)
Query: 159 FHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEA 218
F +H+ L+ + + QL DV+L PAH++VL+A SDYF AMFT + EA
Sbjct: 40 FSAPSHSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREA 99
Query: 219 KQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQ 278
Q+ + ++GV L ++ +AY+ + L D ++ +L AA LQ+ V+++C FL
Sbjct: 100 SQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAA 159
Query: 279 LHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDIN 338
+ CL I L +T HF+++ + ++FL LP + L S+ +
Sbjct: 160 MSVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQ 219
Query: 339 VPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLECQ 397
E +F A ++W+ HD R+ +L +IR PL+ L D ++T + D+ C+
Sbjct: 220 SCAEIDLFRAAVRWLQHD-PARRPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLCR 278
Query: 398 KLLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEK--YDLRTNS 455
+ L+EA Y +LP R+ MQSPRT R S V +L GG ++ Y L
Sbjct: 279 QYLLEAFNYQVLPFRQHEMQSPRTAVR-SDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPG 337
Query: 456 WLHIGTMNGRRLQFG-----VAVIDNKLYVVGG-----RDGLKTLNTVECFNPVGKIWTV 505
H + ++ G VAV+DN +YV GG R G ++ ++P W
Sbjct: 338 ARHFRELT--EMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLR 395
Query: 506 MPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGV 565
+ M R + L G +YA GG + L +VER+ P +W Y S+
Sbjct: 396 LQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAG 455
Query: 566 VALNNKLYAIGGRDGS-SCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGG 624
A +LY GG S K++ +DP ++W APMS+ R + G +Y +GG
Sbjct: 456 AASGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGG 515
Query: 625 HDAPASNHCSRLSD--CVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDG-- 680
+H R D VE Y P+ D W++V+P+ + C L K+Y+VGGY+
Sbjct: 516 R----MDHVDRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNWRL 571
Query: 681 HTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVVVKLP 718
+ V+ Y+ +EW+ ++ AG V LP
Sbjct: 572 NNVTGIVQVYNTDTDEWERDLHFPESFAGIACAPVLLP 609
>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
Length = 589
Score = 245 bits (625), Expect = 1e-64
Identities = 166/569 (29%), Positives = 268/569 (47%), Gaps = 24/569 (4%)
Query: 143 DTQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSA 202
+T+ S + + FH +H + L + K DV L AG P HR VL+A
Sbjct: 7 ETRKSRSSTGSMNVTLFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAA 66
Query: 203 VSDYFAAMFTNDVLEAKQEEVRME-GVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACL 261
S YF AMF++ + E++ + V + + P L L+ +AY+ + + E+ ESLL A +
Sbjct: 67 SSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDM 126
Query: 262 LQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFL 321
LQ V D + FL K L PSNCLG+ DA C L + + + HF V ++++F
Sbjct: 127 LQFHDVRDAAAEFLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFN 186
Query: 322 LLPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLL 381
L + + L+ SD++ DE +F A++QWV HD++ R+ L LL +RL LLP L
Sbjct: 187 SLSKDTLLDLISSDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCL 246
Query: 382 ADLETSSMFTGDLECQKLLM-EAMKYHL-LPERRSMMQSPRTKPRKSTVGALYAVGGMDA 439
+ +S E KL+M EA++ + + ++ SP +PRK+ L +GG
Sbjct: 247 QEAVSSEALLMADERTKLIMDEALRCKTRILQNDGVVTSPCARPRKAG-HTLLILGGQTF 305
Query: 440 MKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLN-TVECFNP 498
M I + D + + + R +F + I K+YV GGR ++ V ++
Sbjct: 306 M--CDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDT 363
Query: 499 VGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWS---------YLNTVERWDPEGRQ 549
V + W+ PM R G G A LE +Y VGGH + L VE++DP +
Sbjct: 364 VHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANK 423
Query: 550 WNYVASMSTPRSTVGVVALNNKLYAIGGRD-GSSCLKSMEYFDPHTNKWSLCAPMSKRRG 608
W VA + S VV+ KL+ GG + ++ +DP N+W++ A +
Sbjct: 424 WMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWR 483
Query: 609 GVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPL 668
A ++++GG + R+D + + W+ + ++ R +
Sbjct: 484 YTAAAVLGSQIFIMGG-------DTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALAS 536
Query: 669 GDKLYVVGGYDGHTYLNTVESYDAQRNEW 697
G+KLYVVGGY G T++ YD + W
Sbjct: 537 GNKLYVVGGYFGTQRCKTLDCYDPTSDTW 565
Score = 75.9 bits (185), Expect = 1e-13
Identities = 46/178 (25%), Positives = 80/178 (44%), Gaps = 11/178 (6%)
Query: 431 LYAVGGMDAMKGT---------TTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVV 481
LY VGG ++ G +EKYD N W+ + + V KL+V
Sbjct: 390 LYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVF 449
Query: 482 GGRDGLKTL-NTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTV 540
GG + + + V+C++P WT+ A L ++ +GG ++ +
Sbjct: 450 GGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGGDTEFTAASAY 509
Query: 541 ERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWS 598
R+D E QW + M+ R + +A NKLY +GG G+ K+++ +DP ++ W+
Sbjct: 510 -RFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWN 566
Score = 46.6 bits (109), Expect = 8e-05
Identities = 34/108 (31%), Positives = 46/108 (42%), Gaps = 14/108 (12%)
Query: 619 LYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGY 678
+YV GG + + +S V YD + WS AP+ + R L + LYVVGG+
Sbjct: 342 VYVTGGRGSE-----NGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGH 396
Query: 679 DG---------HTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVVVKL 717
L VE YD N+W P+ G + A VV KL
Sbjct: 397 TSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKL 444
Score = 39.3 bits (90), Expect = 0.013
Identities = 28/127 (22%), Positives = 52/127 (40%), Gaps = 2/127 (1%)
Query: 431 LYAVGGMDAMKGTTT-IEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKT 489
L+ GG + + ++ YD N W AV+ ++++++GG D T
Sbjct: 446 LFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGG-DTEFT 504
Query: 490 LNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQ 549
+ F+ WT + M+ R +Y VGG+ G T++ +DP
Sbjct: 505 AASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDT 564
Query: 550 WNYVASM 556
WN + ++
Sbjct: 565 WNCITTV 571
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 244 bits (622), Expect = 3e-64
Identities = 161/560 (28%), Positives = 263/560 (46%), Gaps = 35/560 (6%)
Query: 172 MENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPN 231
+E E L DV+L HR+VL+A S+YF AMF ND+ E ++ + ++GVD
Sbjct: 62 LETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAE 121
Query: 232 ALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFG 291
+++L+ Y YT + + ++ +L AA L Q +++D C++FL + L+P NC+GI
Sbjct: 122 TMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLA 181
Query: 292 DAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQ 351
D L Y +++F++++ ++EFL LP + + +L SDD+ V +E +F +M
Sbjct: 182 DTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMS 241
Query: 352 WVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLECQKLLMEAMKYHLLP 410
WV H R L +L +RLPLL P + +E + E LL EA YHL
Sbjct: 242 WVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHL-- 299
Query: 411 ERRSMMQSPRTKPRKSTVGA--LYAVGGMDA-MKGTTTIEKYDLRTNSWLHIGTM----- 462
+ + S RTKPR + +GG + + D S L + +
Sbjct: 300 -SGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTEH 358
Query: 463 -----NGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLG 517
N + ++F + N++Y+ GG++ T + V +N W + ++ R
Sbjct: 359 ELESENKKWVEFACVTLKNEVYISGGKE---TQHDVWKYNSSINKWIQIEYLNIGRWRHK 415
Query: 518 VATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAI-G 576
+ L G +Y +GG DG +N VE +DP W+ A + S+ + KLY I G
Sbjct: 416 MVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGG 475
Query: 577 GRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRL 636
G +G + +DP TNKWSL A M + ++ +YVVGG
Sbjct: 476 GPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGG-----------A 524
Query: 637 SDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYD-GHTYLNTVESYDAQRN 695
+ Y P DSW V LS R + + P ++LY+ GG D + + TV +D +
Sbjct: 525 MRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPEAQ 584
Query: 696 EWKEE--VPVNIGRAGACVV 713
+ EE +P + G+ +
Sbjct: 585 KLTEECVLPRGVSHHGSVTI 604
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,808,294
Number of Sequences: 37866
Number of extensions: 1356540
Number of successful extensions: 4847
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 168
Number of HSP's successfully gapped in prelim test: 43
Number of HSP's that attempted gapping in prelim test: 3320
Number of HSP's gapped (non-prelim): 425
length of query: 718
length of database: 18,247,518
effective HSP length: 110
effective length of query: 608
effective length of database: 14,082,258
effective search space: 8562012864
effective search space used: 8562012864
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.