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Search of human proteins with 167830411
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|167830411 natriuretic peptide receptor 1 [Homo sapiens]
(1061 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|167830411 natriuretic peptide receptor 1 [Homo sapiens] 2139 0.0
gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens] 1241 0.0
gi|134152694 guanylate cyclase 2F [Homo sapiens] 504 e-142
gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Hom... 496 e-140
gi|222080083 guanylate cyclase 2C [Homo sapiens] 450 e-126
gi|4505441 natriuretic peptide receptor C/guanylate cyclase C (a... 217 4e-56
gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens] 181 3e-45
gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Ho... 178 3e-44
gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 178 3e-44
gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 178 3e-44
gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Hom... 178 3e-44
gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 178 3e-44
gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens] 173 9e-43
gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Ho... 172 2e-42
gi|4557257 adenylate cyclase 8 [Homo sapiens] 124 5e-28
gi|148536830 adenylate cyclase 3 [Homo sapiens] 118 3e-26
gi|4557255 adenylate cyclase 7 [Homo sapiens] 118 3e-26
gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens] 117 8e-26
gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens] 117 8e-26
gi|34486092 adenylate cyclase 5 [Homo sapiens] 116 1e-25
gi|24497587 adenylate cyclase 4 [Homo sapiens] 114 5e-25
gi|115387102 adenylate cyclase 2 [Homo sapiens] 113 1e-24
gi|31083193 adenylate cyclase 1 [Homo sapiens] 110 7e-24
gi|50959205 adenylate cyclase 9 [Homo sapiens] 107 8e-23
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens] 100 1e-20
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens] 100 1e-20
gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H... 93 2e-18
gi|75677325 kinase suppressor of ras [Homo sapiens] 93 2e-18
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 92 3e-18
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 91 6e-18
>gi|167830411 natriuretic peptide receptor 1 [Homo sapiens]
Length = 1061
Score = 2139 bits (5543), Expect = 0.0
Identities = 1061/1061 (100%), Positives = 1061/1061 (100%)
Query: 1 MPGPRRPAGSRLRLLLLLLLPPLLLLLRGSHAGNLTVAVVLPLANTSYPWSWARVGPAVE 60
MPGPRRPAGSRLRLLLLLLLPPLLLLLRGSHAGNLTVAVVLPLANTSYPWSWARVGPAVE
Sbjct: 1 MPGPRRPAGSRLRLLLLLLLPPLLLLLRGSHAGNLTVAVVLPLANTSYPWSWARVGPAVE 60
Query: 61 LALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVY 120
LALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVY
Sbjct: 61 LALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVY 120
Query: 121 AAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWER 180
AAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWER
Sbjct: 121 AAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWER 180
Query: 181 QALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGR 240
QALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGR
Sbjct: 181 QALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGR 240
Query: 241 VIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDV 300
VIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDV
Sbjct: 241 VIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDV 300
Query: 301 SARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLY 360
SARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLY
Sbjct: 301 SARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLY 360
Query: 361 IQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAF 420
IQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAF
Sbjct: 361 IQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAF 420
Query: 421 RVVLNYNGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGS 480
RVVLNYNGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGS
Sbjct: 421 RVVLNYNGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGS 480
Query: 481 LSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGSRLTLSGRGSNY 540
LSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGSRLTLSGRGSNY
Sbjct: 481 LSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGSRLTLSGRGSNY 540
Query: 541 GSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVG 600
GSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVG
Sbjct: 541 GSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVG 600
Query: 601 ACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGN 660
ACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGN
Sbjct: 601 ACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGN 660
Query: 661 LKSSNCVVDGRFVLKITDYGLESFRDLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAG 720
LKSSNCVVDGRFVLKITDYGLESFRDLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAG
Sbjct: 661 LKSSNCVVDGRFVLKITDYGLESFRDLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAG 720
Query: 721 DVYSFGIILQEIALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLM 780
DVYSFGIILQEIALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLM
Sbjct: 721 DVYSFGIILQEIALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLM 780
Query: 781 QRCWAEDPQERPPFQQIRLTLRKFNRENSSNILDNLLSRMEQYANNLEELVEERTQAYLE 840
QRCWAEDPQERPPFQQIRLTLRKFNRENSSNILDNLLSRMEQYANNLEELVEERTQAYLE
Sbjct: 781 QRCWAEDPQERPPFQQIRLTLRKFNRENSSNILDNLLSRMEQYANNLEELVEERTQAYLE 840
Query: 841 EKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTL 900
EKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTL
Sbjct: 841 EKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTL 900
Query: 901 LNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFR 960
LNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFR
Sbjct: 901 LNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFR 960
Query: 961 IRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSET 1020
IRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSET
Sbjct: 961 IRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSET 1020
Query: 1021 KAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGERGSSTRG 1061
KAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGERGSSTRG
Sbjct: 1021 KAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGERGSSTRG 1061
>gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens]
Length = 1047
Score = 1241 bits (3212), Expect = 0.0
Identities = 646/1050 (61%), Positives = 777/1050 (74%), Gaps = 25/1050 (2%)
Query: 16 LLLLLPPLLLLLRGSHAGNLTVAVVLPLANTSYPWSWARVGPAVELALAQVKARPDLLPG 75
LLLL+ L +R A NLT+AVVLP N SY W+W RVGPAV LA V+A LP
Sbjct: 6 LLLLVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPRVGPAVALA---VEALGRALPV 62
Query: 76 WTVRTVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVYAAAPVGRFTAHWRVP 135
+R V E G CS+ APL+AVDLK H+P + LGPGCVY AA V RF +HWR+P
Sbjct: 63 -DLRFVSSELE---GACSEYLAPLSAVDLKLYHDPDLLLGPGCVYPAASVARFASHWRLP 118
Query: 136 LLTAGAPALGFGVK-DEYALTTRAGPSYAKLGDFVAALHRRLGWERQALMLYAYRPGDEE 194
LLTAGA A GF K D Y R GPS KLG+FV LH W +A +LY D+
Sbjct: 119 LLTAGAVASGFSAKNDHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDR 178
Query: 195 HCFFLVEGLFMRVRDRLNITVDHLEFAED-----DLSHYTRLLRTMPRKGRVIYICSSPD 249
+F +EG+F ++ N++V H +A + +H+ R GR++YIC +
Sbjct: 179 PHYFTIEGVFEALQGS-NLSVQHQVYAREPGGPEQATHFIRA------NGRIVYICGPLE 231
Query: 250 AFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWE--RGDGQDVSARQAFQ 307
++L A L DYVFF+LD+FG+SL+ G A RPW+ R Q + R+AFQ
Sbjct: 232 MLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTREQAQALREAFQ 291
Query: 308 AAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTET 367
+ITY++P NPEY EF +L A E F + L+N I F+DG+LLY + + ET
Sbjct: 292 TVLVITYREPPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNET 351
Query: 368 LAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDM-DPENGAFRVVLNY 426
+ GGT DG I ++M R + GVTG + +D + DRETDF LW M D ++G F+ +Y
Sbjct: 352 IQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHY 411
Query: 427 NGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGSLSLLGI 486
+G ++ + +GR + W G PP D P C FD +DP+C++ LSTL ++AL ++ +
Sbjct: 412 SGAEKQ-IWWTGRPIPWVKGAPPSDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMF 470
Query: 487 LIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGSRLTLSGRGSNYGSLLTT 546
+ SF I+RK+ LEKELAS LWR+RWE+++ + ER+ + AGSRLTLS RGS+YGSL+T
Sbjct: 471 GVSSFLIFRKLMLEKELASMLWRIRWEELQFGNSERYHKGAGSRLTLSLRGSSYGSLMTA 530
Query: 547 EGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPP 606
G++Q+FA T ++KGN+VA+K VN+KRIELTR+VLFELKHMRDVQ HLTRF+GAC DPP
Sbjct: 531 HGKYQIFANTGHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPP 590
Query: 607 NICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNC 666
NICI+TEYCPRGSLQDILEN+SI LDWMFRYSL ND+VKGM FLHN I SHG+LKSSNC
Sbjct: 591 NICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNC 650
Query: 667 VVDGRFVLKITDYGLESFRDL-DPEQGHTVYAKKLWTAPELLRMASPPVRGSQAGDVYSF 725
VVD RFVLKITDYGL SFR +P+ H +YAKKLWTAPELL P G Q DVYSF
Sbjct: 651 VVDSRFVLKITDYGLASFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSF 710
Query: 726 GIILQEIALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLMQRCWA 785
GIILQEIALRSG F++EGLDLSPKEI+++V G++P FRPS+ EEL LLM+RCWA
Sbjct: 711 GIILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWA 770
Query: 786 EDPQERPPFQQIRLTLRKFNRENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKA 845
+DP ERP F QI+ +R+FN+E ++ILDNLL RMEQYANNLE+LVEERTQAYLEEKRKA
Sbjct: 771 QDPAERPDFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKA 830
Query: 846 EALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLY 905
EALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLY
Sbjct: 831 EALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLY 890
Query: 906 TCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRP 965
TCFDA+IDNFDVYKVETIGDAYMVVSGLP RNG+ HA E+ARMALALLDAV SFRIRHRP
Sbjct: 891 TCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRP 950
Query: 966 QEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLE 1025
+QLRLRIG+HTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNG+ALKIH+SS TK L+
Sbjct: 951 HDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALD 1010
Query: 1026 EFGGFELELRGDVEMKGKGKVRTYWLLGER 1055
E G F+LELRGDVEMKGKGK+RTYWLLGER
Sbjct: 1011 ELGCFQLELRGDVEMKGKGKMRTYWLLGER 1040
>gi|134152694 guanylate cyclase 2F [Homo sapiens]
Length = 1108
Score = 504 bits (1297), Expect = e-142
Identities = 313/777 (40%), Positives = 454/777 (58%), Gaps = 39/777 (5%)
Query: 303 RQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQ 362
R+A+ A IT + + Y F + A + +E V+ + + ++ + Q
Sbjct: 305 REAYDAVLTITVESQEKTFYQAFTEAA---ARGEIPEKLEFDQVSPLFGTIYNSIYFIAQ 361
Query: 363 AVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRV 422
A+ + G ++ Q N F G ++ DS+G+ +++ + D + +
Sbjct: 362 AMNNAMKENGQA-GAASLVQHSRNMQFHGFNQLMRTDSNGNGISEYVILDTNLKEWELHS 420
Query: 423 VLNYNGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGSLS 482
+ EL+ G +++P G PP KC F + ++ L ++
Sbjct: 421 TYTVD-MEMELLRFGGTPIHFPGGRPPRADAKCWFAEGKICHGGIDPAFAMMVCLTLLIA 479
Query: 483 LLGILIVSFFIYR---KMQLEKELASELWRVRWEDVEPSSLERHLRSA-GSRLTLS---- 534
LL I ++FI R K+QL K L + EDV + + H S GSR ++S
Sbjct: 480 LLSINGFAYFIRRRINKIQLIKGPNRILLTL--EDV--TFINPHFGSKRGSRASVSFQIT 535
Query: 535 -----GRGS--NYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVNR------KRIELTRKVL 581
GR ++ S T ++ + A Y+G+ V +K+ + K I+ +
Sbjct: 536 SEVQSGRSPRLSFSSGSLTPATYEN-SNIAIYEGDWVWLKKFSLGDFGDLKSIKSRASDV 594
Query: 582 FELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTN 641
FE+ M+D+++E++ +G D I+TE+C RGSL+DIL N+ + LDWMF+ SL
Sbjct: 595 FEM--MKDLRHENINPLLGFFYDSGMFAIVTEFCSRGSLEDILTNQDVKLDWMFKSSLLL 652
Query: 642 DIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRD-LDPEQGHTVYAKKL 700
D++KGM +LH+ HG LKS NCVVDGRFVLK+TDYG + L + + + L
Sbjct: 653 DLIKGMKYLHHREFV-HGRLKSRNCVVDGRFVLKVTDYGFNDILEMLRLSEEESSMEELL 711
Query: 701 WTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFHVEGLDLSPKEIIERVTRGEQ 760
WTAPELLR GS AGDVYSF II+QE+ +R F + +DL +EII R+ +
Sbjct: 712 WTAPELLRAPRGSRLGSFAGDVYSFAIIMQEVMVRGTPFCM--MDLPAQEIINRLKK-PP 768
Query: 761 PPFRPSLALQSHLEELGLLMQRCWAEDPQERPPFQQIRLTLRKFNRENSSNILDNLLSRM 820
P +RP + + E LM++CWAE ++RP F +I + FN+ +NI+D++L +
Sbjct: 769 PVYRPVVPPEHAPPECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNKGKKTNIIDSMLRML 828
Query: 821 EQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFS 880
EQY++NLE+L+ ERT+ EK+K E LL Q+LP SVAE LK+G TV+ E FD VT+YFS
Sbjct: 829 EQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYFS 888
Query: 881 DIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRL 940
DIVGFT +SA S P++VV LLNDLYT FDA+I + DVYKVETIGDAYMV SGLP RNG
Sbjct: 889 DIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSR 948
Query: 941 HACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVN 1000
HA E+A M+L +L +V +F++RH P+ +R+RIG+H+GPV AGVVGL MPRYCLFGDTVN
Sbjct: 949 HAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVN 1008
Query: 1001 TASRMESNGEALKIHLSSETKAVLEEFG-GFELELRGDVEMKGKGKVRTYWLLGERG 1056
TASRMES G +IH+S T +L+ G+E+ELRG E+KGKG T+WL+G++G
Sbjct: 1009 TASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWLIGKKG 1065
>gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Homo
sapiens]
Length = 1103
Score = 496 bits (1276), Expect = e-140
Identities = 378/1089 (34%), Positives = 547/1089 (50%), Gaps = 97/1089 (8%)
Query: 4 PRRPAGSRLRLLLLLLLPPLLLLLRGSHAGNLTVAVVLPLANTSYPWSWARVGPAVELAL 63
PR P L LLLLLL PP L + TV V+ P A +S AR A LA
Sbjct: 34 PRLP----LLLLLLLLQPPAL-------SAVFTVGVLGPWACDPI-FSRARPDLAARLAA 81
Query: 64 AQVKARPDLLPGWTVRTVL----GSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCV 119
A++ P L G L + +LG S A ++ + +GP
Sbjct: 82 ARLNRDPGLAGGPRFEVALLPEPCRTPGSLGAVSSALARVSGL-----------VGPVNP 130
Query: 120 YAAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWE 179
A P + L+ G P A T A P+ D + AL R GW
Sbjct: 131 AACRPAELLAEEAGIALVPWGCPW-------TQAEGTTA-PAVTPAADALYALLRAFGWA 182
Query: 180 RQALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTM---P 236
R AL+ ++ L +R R DLS LR + P
Sbjct: 183 RVALV-----TAPQDLWVEAGRSLSTALRARGLPVASVTSMEPLDLSGAREALRKVRDGP 237
Query: 237 RKGRVIYICSS----PDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPW 292
R VI + S + R L+ A E GL VF D +L P P
Sbjct: 238 RVTAVIMVMHSVLLGGEEQRYLLEAAEELGLTDGSLVFLPFDTIHYAL----SPGPEALA 293
Query: 293 ERGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPAS 352
+ + R+A A +T P L+ L++ + + ++ V+ + +
Sbjct: 294 ALANSSQL--RRAHDAVLTLTRHCPSEGSVLDSLRRAQERRELPSDLNLQQ--VSPLFGT 349
Query: 353 FHDGLLLYIQAVTET-LAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLW 411
+D + L + V E A GG G + + + + G G D GD E F L
Sbjct: 350 IYDAVFLLARGVAEARAAAGGRWVSGAAVARHIRDAQVPGFCG----DLGGDEEPPFVLL 405
Query: 412 DMDPENGAFRVVLNYNGTSQELVAVSGRKLNWPLG--YPPPDIPKCGFDNEDPACN---Q 466
D D + ++ +G ++++P G P PD P C FD + C +
Sbjct: 406 DTDAAGDRLFATYMLDPARGSFLS-AGTRMHFPRGGSAPGPD-PSCWFDPNN-ICGGGLE 462
Query: 467 DHLSTLEVLALVGSLSLLGILIVSFFIYRKMQLEKELASELWRVRWEDV---EPSSLERH 523
L L L +VG + L G + + +R + ++ + +D+ P
Sbjct: 463 PGLVFLGFLLVVG-MGLAGAFLAHYVRHRLLHMQMVSGPNKIILTVDDITFLHPHGGTSR 521
Query: 524 LRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRV-NRKRIELTRKVLF 582
+ GSR +L R + + + Q Y+G+ V +K+ + I +
Sbjct: 522 KVAQGSRSSLGAR--SMSDIRSGPSQHLDSPNIGVYEGDRVWLKKFPGDQHIAIRPATKT 579
Query: 583 ELKHMRDVQNEHLTRFVG----------ACTDPPNICILTEYCPRGSLQDILENESITLD 632
++++++E++ ++G A N+ +++E+C RGSLQD+L I LD
Sbjct: 580 AFSKLQELRHENVALYLGLFLARGAEGPAALWEGNLAVVSEHCTRGSLQDLLAQREIKLD 639
Query: 633 WMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYG----LESFRDLD 688
WMF+ SL D++KG+ +LH+ + +HG LKS NC+VDGRFVLKITD+G LE+ + L
Sbjct: 640 WMFKSSLLLDLIKGIRYLHHRGV-AHGRLKSRNCIVDGRFVLKITDHGHGRLLEAQKVL- 697
Query: 689 PEQGHTVYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFHVEGLDLSP 748
PE +LWTAPELLR + RG+ AGDV+S II+QE+ RS + + L+L+P
Sbjct: 698 PEPPRA--EDQLWTAPELLRDPALERRGTLAGDVFSLAIIMQEVVCRSAPYAM--LELTP 753
Query: 749 KEIIERVTRGEQPPFRPSLALQSHLEELGLLMQRCWAEDPQERPPFQQIRLTLRKFNREN 808
+E+++RV R P RP +++ E LLM++CWAE P+ RP + N+
Sbjct: 754 EEVVQRV-RSPPPLCRPLVSMDQAPVECILLMKQCWAEQPELRPSMDHTFDLFKNINKGR 812
Query: 809 SSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQ 868
+NI+D++L +EQY++NLE+L+ ERT+ EK+K + LL Q+LP SVAE LK G V+
Sbjct: 813 KTNIIDSMLRMLEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVE 872
Query: 869 AEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYM 928
E F+ VT+YFSDIVGFT +SA S P++VV LLNDLYT FDA+I + DVYKVETIGDAYM
Sbjct: 873 PEYFEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYM 932
Query: 929 VVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLK 988
V SGLP RNG+ HA E+A M+L +L AV +FR+RH P+ +R+RIG+H+GP AGVVGL
Sbjct: 933 VASGLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLT 992
Query: 989 MPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEF-GGFELELRGDVEMKGKGKVR 1047
MPRYCLFGDTVNTASRMES G +IH++ T +L G+++ELRG E+KGKG
Sbjct: 993 MPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAED 1052
Query: 1048 TYWLLGERG 1056
T+WL+G RG
Sbjct: 1053 TFWLVGRRG 1061
>gi|222080083 guanylate cyclase 2C [Homo sapiens]
Length = 1073
Score = 450 bits (1157), Expect = e-126
Identities = 335/985 (34%), Positives = 488/985 (49%), Gaps = 143/985 (14%)
Query: 112 VFLGPGCVYAAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALT-TRAGPSYAKLGDFVA 170
V +GP C Y+ + T P+++AG+ FG+ +Y T TR KL F+
Sbjct: 118 VLIGPSCTYSTFQMYLDT-ELSYPMISAGS----FGLSCDYKETLTRLMSPARKLMYFLV 172
Query: 171 ALHRRLGWERQALML--------YAYRPGDE-EHCFFLVEGLFMRVRDRLNITVDHLEFA 221
W+ L Y Y+ G E E CF+ + L V + +
Sbjct: 173 NF-----WKTNDLPFKTYSWSTSYVYKNGTETEDCFWYLNALEASVSYFSHELGFKVVLR 227
Query: 222 EDDLSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLC-GEDYVFFHLDIFGQSL 280
+D + +L RK VI +C P+ L L+ ED V +D+F
Sbjct: 228 QD--KEFQDILMDHNRKSNVIIMCGGPE-----FLYKLKGDRAVAEDIVIILVDLFND-- 278
Query: 281 QGGQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFT 340
Q F+ DN +++K + L N
Sbjct: 279 -----------------------QYFE----------DNVTAPDYMKNVLVLTLSPGNSL 305
Query: 341 MEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVT----DGENITQRMW-----NRSFQG 391
+ + + D L Y+ + L G + +GENIT + N +F+G
Sbjct: 306 LNSSFSRNLSPTKRDFALAYLNGI---LLFGHMLKIFLENGENITTPKFAHAFRNLTFEG 362
Query: 392 VTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVS-GRKLNWPLGYPPP 450
G + +D GD ++ L + ++V+L Y+ + V W P
Sbjct: 363 YDGPVTLDDWGDVDSTMVLLYTSVDTKKYKVLLTYDTHVNKTYPVDMSPTFTWKNSKLPN 422
Query: 451 DIPKCGFDNEDPACNQDHLSTLEVLALVGSLSLLGILIVSFFIYRKMQLEKELASELWRV 510
DI G + + V L G++ LL L+V+ + RK + + EL +
Sbjct: 423 DITGRG----------PQILMIAVFTLTGAVVLL--LLVALLMLRKYRKDYELRQK---- 466
Query: 511 RWEDVEPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQ----FQVFAKTAYYKGNLVAV 566
+W + P ++ L +N+ SL + + Q + Y K ++ +
Sbjct: 467 KWSHIPPENI----------FPLETNETNHVSLKIDDDKRRDTIQRLRQCKYDKKRVI-L 515
Query: 567 KRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILEN 626
K + T K EL + + +LT+F G I + EYC RGSL+++L N
Sbjct: 516 KDLKHNDGNFTEKQKIELNKLLQIDYYNLTKFYGTVKLDTMIFGVIEYCERGSLREVL-N 574
Query: 627 ESIT------LDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYG 680
++I+ +DW F+ S+ DI KGM +LH+ HG LKS+NCVVD R V+KITD+G
Sbjct: 575 DTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFG 634
Query: 681 LESFRDLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFH 740
S L P+ K LWTAPE LR A+ SQ GDVYS+GII QEI LR F+
Sbjct: 635 CNSI--LPPK-------KDLWTAPEHLRQANI----SQKGDVYSYGIIAQEIILRKETFY 681
Query: 741 VEGLDLSPKEIIERVTRGEQP----PFRPSLALQSHLE---ELGLLMQRCWAEDPQERPP 793
LS ++ E++ R E PFRP L L++ E E+ LL++ CW EDP++RP
Sbjct: 682 T----LSCRDRNEKIFRVENSNGMKPFRPDLFLETAEEKELEVYLLVKNCWEEDPEKRPD 737
Query: 794 FQQIRLTLRK----FNRENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALL 849
F++I TL K F+ + + + +D L+ R++ Y+ NLE LVEERTQ Y E+ +A+ L
Sbjct: 738 FKKIETTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLN 797
Query: 850 YQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFD 909
+ +LP V + LK V+ E ++ VTIYFSDIVGFT + STPM+VV +LND+Y FD
Sbjct: 798 FMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFD 857
Query: 910 AVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQL 969
++D+ DVYKVETIGDAYMV SGLP RNG HA ++A+MAL +L + +F + H P +
Sbjct: 858 HIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPI 917
Query: 970 RLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFG- 1028
+RIG+H+GP AGVVG+KMPRYCLFGDTVNTASRMES G L+IH+S T A+L+
Sbjct: 918 WIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTEC 977
Query: 1029 GFELELRGDVEMKGKGKVRTYWLLG 1053
F E+RG+ +KG+G TYWL G
Sbjct: 978 QFLYEVRGETYLKGRGNETTYWLTG 1002
>gi|4505441 natriuretic peptide receptor C/guanylate cyclase C
(atrionatriuretic peptide receptor C) [Homo sapiens]
Length = 540
Score = 217 bits (553), Expect = 4e-56
Identities = 167/502 (33%), Positives = 249/502 (49%), Gaps = 42/502 (8%)
Query: 35 LTVAVVLPLANTSYPWSWARVGPAVELALAQVKA----RPDLLPGWTVRTVLGSSE---N 87
+ V V+LP + SY +S RV PA+E AL V+ R L PG + S+
Sbjct: 53 IEVLVLLP-QDDSYLFSLTRVRPAIEYALRSVEGNGTGRRLLPPGTRFQVAYEDSDCGNR 111
Query: 88 ALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVYAAAPVGRFTAHWRVPLLTAGAPALGFG 147
AL D A P + LGP C YAAAPV R +HW +P+L+AGA A GF
Sbjct: 112 ALFSLVDRVAAARGA------KPDLILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQ 165
Query: 148 VKD-EYALTTRAGPSYAKLGDFVAALHRRLGWERQALMLYAYRPGDEEHCFFLVEGLFMR 206
KD EY+ TR P+YAK+G+ + AL R W R AL+ + E +C+F +EG+
Sbjct: 166 HKDSEYSHLTRVAPAYAKMGEMMLALFRHHHWSRAALVYSDDKL--ERNCYFTLEGVHEV 223
Query: 207 VRDR-LNITVDHLEFAED-DLSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLC 264
++ L+ ++ + +D DL ++R + RV+ +C+S D R++ML+A G+
Sbjct: 224 FQEEGLHTSIYSFDETKDLDLED---IVRNIQASERVVIMCASSDTIRSIMLVAHRHGMT 280
Query: 265 GEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDPDNPEYLE 324
DY FF++++F S G W+RGD D A+QA+ + + +T PE+ +
Sbjct: 281 SGDYAFFNIELFNSSSYGDGS------WKRGDKHDFEAKQAYSSLQTVTLLRTVKPEFEK 334
Query: 325 FLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRM 384
F ++K + E+ MED VN FHD +LLY+ A+ E L G + DG I Q+
Sbjct: 335 FSMEVKS-SVEKQGLNMED-YVNMFVEGFHDAILLYVLALHEVLRAGYSKKDGGKIIQQT 392
Query: 385 WNRSFQGVTGYLKIDSSGDRETDFSLWDM-DPENGAFRVVLNYNGTSQELVAVSGRKLNW 443
WNR+F+G+ G + ID++GDR DFS+ M D E G V+ +Y G K W
Sbjct: 393 WNRTFEGIAGQVSIDANGDRYGDFSVIAMTDVEAGTQEVIGDYFGKEGRFEMRPNVKYPW 452
Query: 444 -PLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLAL-VGSLSLLGILIVSFFIYRKMQLEK 501
PL + N P C L V + VG+L G+L+ +F +K ++
Sbjct: 453 GPLKLRIDENRIVEHTNSSP-CKSCGLEESAVTGIVVGALLGAGLLMAFYFFRKKYRITI 511
Query: 502 ELASELWRVRWEDVEPSSLERH 523
E R E S+L +H
Sbjct: 512 E--------RRTQQEESNLGKH 525
>gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens]
Length = 732
Score = 181 bits (459), Expect = 3e-45
Identities = 105/227 (46%), Positives = 141/227 (62%), Gaps = 7/227 (3%)
Query: 814 DNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFD 873
D L RM++ L+ +E QA EEK+K LLY I P VA+QL +G+ VQA FD
Sbjct: 463 DGLKKRMDK----LKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFD 518
Query: 874 SVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGL 933
VT+ FSDIVGFTA+ A+ TPMQV+++LN+LYT FD D+YKVETIGDAY V +GL
Sbjct: 519 DVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGL 578
Query: 934 PVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYC 993
R HA +A MAL +++ S + +++RIGIH+G V AGVVG++MPRYC
Sbjct: 579 H-RKSLCHAKPIALMALKMMEL--SEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYC 635
Query: 994 LFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEM 1040
LFG+ V AS+ ES +I++S T +L+ F R E+
Sbjct: 636 LFGNNVTLASKFESGSHPRRINVSPTTYQLLKREESFTFIPRSREEL 682
>gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Homo
sapiens]
Length = 455
Score = 178 bits (451), Expect = 3e-44
Identities = 99/221 (44%), Positives = 141/221 (63%), Gaps = 3/221 (1%)
Query: 820 MEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYF 879
+++ L+ +E+ QA EEK+K LL I P VA+QL +G+ VQA+ F +VT+ F
Sbjct: 190 LKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLF 249
Query: 880 SDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGR 939
SDIVGFTA+ ++ +P+QV+T+LN LYT FD DVYKVETIGDAY V GL +
Sbjct: 250 SDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLH-KESD 308
Query: 940 LHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTV 999
HA ++A MAL +++ S + E +++RIG+H+G V AGVVG+KMPRYCLFG+ V
Sbjct: 309 THAVQIALMALKMMEL--SDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNV 366
Query: 1000 NTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEM 1040
A++ ES KI++S T +L++ GF R E+
Sbjct: 367 TLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREEL 407
>gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 178 bits (451), Expect = 3e-44
Identities = 99/221 (44%), Positives = 141/221 (63%), Gaps = 3/221 (1%)
Query: 820 MEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYF 879
+++ L+ +E+ QA EEK+K LL I P VA+QL +G+ VQA+ F +VT+ F
Sbjct: 425 LKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLF 484
Query: 880 SDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGR 939
SDIVGFTA+ ++ +P+QV+T+LN LYT FD DVYKVETIGDAY V GL +
Sbjct: 485 SDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLH-KESD 543
Query: 940 LHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTV 999
HA ++A MAL +++ S + E +++RIG+H+G V AGVVG+KMPRYCLFG+ V
Sbjct: 544 THAVQIALMALKMMEL--SDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNV 601
Query: 1000 NTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEM 1040
A++ ES KI++S T +L++ GF R E+
Sbjct: 602 TLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREEL 642
>gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 178 bits (451), Expect = 3e-44
Identities = 99/221 (44%), Positives = 141/221 (63%), Gaps = 3/221 (1%)
Query: 820 MEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYF 879
+++ L+ +E+ QA EEK+K LL I P VA+QL +G+ VQA+ F +VT+ F
Sbjct: 425 LKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLF 484
Query: 880 SDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGR 939
SDIVGFTA+ ++ +P+QV+T+LN LYT FD DVYKVETIGDAY V GL +
Sbjct: 485 SDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLH-KESD 543
Query: 940 LHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTV 999
HA ++A MAL +++ S + E +++RIG+H+G V AGVVG+KMPRYCLFG+ V
Sbjct: 544 THAVQIALMALKMMEL--SDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNV 601
Query: 1000 NTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEM 1040
A++ ES KI++S T +L++ GF R E+
Sbjct: 602 TLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREEL 642
>gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 178 bits (451), Expect = 3e-44
Identities = 99/221 (44%), Positives = 141/221 (63%), Gaps = 3/221 (1%)
Query: 820 MEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYF 879
+++ L+ +E+ QA EEK+K LL I P VA+QL +G+ VQA+ F +VT+ F
Sbjct: 425 LKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLF 484
Query: 880 SDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGR 939
SDIVGFTA+ ++ +P+QV+T+LN LYT FD DVYKVETIGDAY V GL +
Sbjct: 485 SDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLH-KESD 543
Query: 940 LHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTV 999
HA ++A MAL +++ S + E +++RIG+H+G V AGVVG+KMPRYCLFG+ V
Sbjct: 544 THAVQIALMALKMMEL--SDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNV 601
Query: 1000 NTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEM 1040
A++ ES KI++S T +L++ GF R E+
Sbjct: 602 TLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREEL 642
>gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 178 bits (451), Expect = 3e-44
Identities = 99/221 (44%), Positives = 141/221 (63%), Gaps = 3/221 (1%)
Query: 820 MEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYF 879
+++ L+ +E+ QA EEK+K LL I P VA+QL +G+ VQA+ F +VT+ F
Sbjct: 425 LKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLF 484
Query: 880 SDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGR 939
SDIVGFTA+ ++ +P+QV+T+LN LYT FD DVYKVETIGDAY V GL +
Sbjct: 485 SDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLH-KESD 543
Query: 940 LHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTV 999
HA ++A MAL +++ S + E +++RIG+H+G V AGVVG+KMPRYCLFG+ V
Sbjct: 544 THAVQIALMALKMMEL--SDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNV 601
Query: 1000 NTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEM 1040
A++ ES KI++S T +L++ GF R E+
Sbjct: 602 TLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREEL 642
>gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens]
Length = 619
Score = 173 bits (438), Expect = 9e-43
Identities = 109/255 (42%), Positives = 147/255 (57%), Gaps = 20/255 (7%)
Query: 821 EQYANNLE-ELVEERTQAYL----EEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSV 875
E+Y E E++ +R Q L +EK+K + LLY +LP SVA +L+ V A+ +D+V
Sbjct: 361 EEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNV 420
Query: 876 TIYFSDIVGFTALSAEST----PMQVVTLLNDLYTCFDAVID---NFDVYKVETIGDAYM 928
TI FS IVGF A ++ M++V LLNDLYT FD + D N VYKVET+GD YM
Sbjct: 421 TILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYM 480
Query: 929 VVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLK 988
VSGLP HA + +AL +++ ++ E +++ IGIHTG V GV+G +
Sbjct: 481 TVSGLP-EPCIHHARSICHLALDMMEIAGQVQV---DGESVQITIGIHTGEVVTGVIGQR 536
Query: 989 MPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVL----EEFGGFELELRGDVEMKGKG 1044
MPRYCLFG+TVN SR E+ GE KI++S T L F LE RG V MKGK
Sbjct: 537 MPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKK 596
Query: 1045 KVRTYWLLGERGSST 1059
+ W L + + T
Sbjct: 597 EPMQVWFLSRKNTGT 611
>gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Homo
sapiens]
Length = 624
Score = 172 bits (436), Expect = 2e-42
Identities = 94/201 (46%), Positives = 132/201 (65%), Gaps = 3/201 (1%)
Query: 820 MEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYF 879
+++ L+ +E+ QA EEK+K LL I P VA+QL +G+ VQA+ F +VT+ F
Sbjct: 425 LKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLF 484
Query: 880 SDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGR 939
SDIVGFTA+ ++ +P+QV+T+LN LYT FD DVYKVETIGDAY V GL +
Sbjct: 485 SDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLH-KESD 543
Query: 940 LHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTV 999
HA ++A MAL +++ S + E +++RIG+H+G V AGVVG+KMPRYCLFG+ V
Sbjct: 544 THAVQIALMALKMMEL--SDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNV 601
Query: 1000 NTASRMESNGEALKIHLSSET 1020
A++ ES KI++S T
Sbjct: 602 TLANKFESCSVPRKINVSPTT 622
>gi|4557257 adenylate cyclase 8 [Homo sapiens]
Length = 1251
Score = 124 bits (311), Expect = 5e-28
Identities = 83/242 (34%), Positives = 135/242 (55%), Gaps = 23/242 (9%)
Query: 832 EERTQAYLEEKRKAEALLYQILPHSVA----EQLKRGETVQAEAFDSVTIYFSDIVGFTA 887
+E E + E +L ILP VA E+ + E + ++++D+V + F+ I GF
Sbjct: 934 KEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFAD 993
Query: 888 LSAESTP----MQVVTLLNDLYTCFDAVI--DNF-DVYKVETIGDAYMVVSGLPVRNGRL 940
+++ ++ + LLN++ FD ++ D F D+ K++TIG YM VSGL +
Sbjct: 994 FYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQC 1053
Query: 941 -----HACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLF 995
H C +A +LAL ++++ I LRIGI G V AGV+G K P+Y ++
Sbjct: 1054 EDKWGHLCALADFSLALTESIQE--INKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIW 1111
Query: 996 GDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKG----KGKVRTYWL 1051
G TVN ASRM+S G + +I + ET +L++ GF + RG++ +KG +GK++TY+L
Sbjct: 1112 GKTVNLASRMDSTGVSGRIQVPEETYLILKD-QGFAFDYRGEIYVKGISEQEGKIKTYFL 1170
Query: 1052 LG 1053
LG
Sbjct: 1171 LG 1172
Score = 102 bits (254), Expect = 2e-21
Identities = 77/260 (29%), Positives = 130/260 (50%), Gaps = 30/260 (11%)
Query: 808 NSSNILDNLLSRMEQYANNLE--ELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGE 865
N++ I + LS Q LE VE R + E +R+ E L+ +LP V ++
Sbjct: 332 NTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQ-ERLVLSVLPRFVVLEMINDM 390
Query: 866 T-------------VQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVI 912
T + +++V+I F+D+ GFT LS + ++V +LN+L+ FD +
Sbjct: 391 TNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLA 450
Query: 913 DNFDVYKVETIGDAYMVVSGLP-VRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRL 971
+++ +GD Y VSGLP R H C M L+++ +R +R R + + +
Sbjct: 451 HEHHCLRIKILGDCYYCVSGLPEPRQDHAHCC--VEMGLSMIKTIR--YVRSRTKHDVDM 506
Query: 972 RIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFE 1031
RIGIH+G V GV+GL+ ++ ++ V+ A+++ES G +IH+S T L G +
Sbjct: 507 RIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLN--GDYN 564
Query: 1032 LELRGDVEMKGKGKVRTYWL 1051
+E +G GK R +L
Sbjct: 565 VE-------EGHGKERNEFL 577
>gi|148536830 adenylate cyclase 3 [Homo sapiens]
Length = 1144
Score = 118 bits (296), Expect = 3e-26
Identities = 79/251 (31%), Positives = 131/251 (52%), Gaps = 31/251 (12%)
Query: 831 VEERTQAYLEEKRKAEALLYQILPHSVAEQL----KRGETVQAEAFDSVTIYFSDIVGF- 885
V ++ + E +R EAL+ +LP VA KR E + ++ +D + + F+ + F
Sbjct: 874 VHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGVMFASLPNFA 933
Query: 886 ---TALSAESTPMQVVTLLNDLYTCFDAVIDNFD---VYKVETIGDAYMVVSGLPV---- 935
T S + ++ + LN++ + FD+++DN + K++TIG YM SG+
Sbjct: 934 DFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNT 993
Query: 936 -------------RNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCA 982
R H ++A ALA+ D + + I ++ LRIG++ G V A
Sbjct: 994 NGFASSNKEDKSERERWQHLADLADFALAMKDTLTN--INNQSFNNFMLRIGMNKGGVLA 1051
Query: 983 GVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKG 1042
GV+G + P Y ++G+TVN ASRMES G I + ET+ +L E+ GF RG + +KG
Sbjct: 1052 GVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREY-GFRFVRRGPIFVKG 1110
Query: 1043 KGKVRTYWLLG 1053
KG++ T++L G
Sbjct: 1111 KGELLTFFLKG 1121
Score = 105 bits (261), Expect = 3e-22
Identities = 64/207 (30%), Positives = 115/207 (55%), Gaps = 18/207 (8%)
Query: 840 EEKRKAEALLYQILPHSVAEQL----KRGE---------TVQAEAFDSVTIYFSDIVGFT 886
E+ ++ E L+ ILP VA+++ K+ E T+ ++V+I F+DIVGFT
Sbjct: 270 EQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFT 329
Query: 887 ALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVA 946
LS+ + ++V LLN+L+ FD + + +++ +GD Y + GLP C +
Sbjct: 330 QLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSIL 389
Query: 947 RMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRME 1006
M LA+++A+ +R + + + +R+G+HTG V GV+G K +Y ++ V A++ME
Sbjct: 390 -MGLAMVEAIS--YVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKME 446
Query: 1007 SNGEALKIHLSSETKAVLEEFGGFELE 1033
+ G ++H+S T L+ G F++E
Sbjct: 447 AGGIPGRVHISQSTMDCLK--GEFDVE 471
>gi|4557255 adenylate cyclase 7 [Homo sapiens]
Length = 1080
Score = 118 bits (295), Expect = 3e-26
Identities = 85/258 (32%), Positives = 133/258 (51%), Gaps = 26/258 (10%)
Query: 817 LSRMEQYANNLEELVEERTQAYLEEKRKAE----ALLYQILPHSVAEQL---KRGETVQA 869
LSR Y L+ L +++ + EE E LL +LP VA K E
Sbjct: 813 LSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKLNEDWYH 872
Query: 870 EAFDSVTIYFSDI----VGFTALSAESTPMQVVTLLNDLYTCFDAVI--DNFD-VYKVET 922
+++D V + F+ + V +T ++ + LLN++ FD ++ F V K++T
Sbjct: 873 QSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKT 932
Query: 923 IGDAYMVVSGLPVRNGR---------LHACEVARMALALLDAVRSFRIRHRPQEQLRLRI 973
IG YM +GL V +G H + ++AL+ + I RLR+
Sbjct: 933 IGSTYMAAAGLSVASGHENQELERQHAHIGVMVEFSIALMSKLDG--INRHSFNSFRLRV 990
Query: 974 GIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELE 1033
GI+ GPV AGV+G + P+Y ++G+TVN ASRMES GE KI ++ ET +L+ G+ E
Sbjct: 991 GINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGL-GYSCE 1049
Query: 1034 LRGDVEMKGKGKVRTYWL 1051
RG + +KGKG++RTY++
Sbjct: 1050 CRGLINVKGKGELRTYFV 1067
Score = 103 bits (258), Expect = 7e-22
Identities = 70/238 (29%), Positives = 130/238 (54%), Gaps = 29/238 (12%)
Query: 841 EKRKAEALLYQILPHSVA--------EQLKRG-----------ETVQAEAFDSVTIYFSD 881
EKR+ E LL +LP ++ E+LK ++ + +V+I ++D
Sbjct: 225 EKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYAD 284
Query: 882 IVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLH 941
IVGFT L+++ +P ++V +LN+L+ FD + + +++ +GD Y VSGLPV + H
Sbjct: 285 IVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPV-SLPTH 343
Query: 942 ACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNT 1001
A +M L + A++ ++R + +R+GIH+G V GV+GL+ +Y ++ V+
Sbjct: 344 ARNCVKMGLDMCQAIK--QVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSL 401
Query: 1002 ASRMESNGEALKIHLSSETKAVLEEFGGFELE----LRGDVEMKGKGKVRTYWLLGER 1055
A+RME+ G ++H++ T L++ +E+E + D +K + +RTY ++ R
Sbjct: 402 ANRMEAAGVPGRVHITEATLKHLDK--AYEVEDGHGQQRDPYLK-EMNIRTYLVIDPR 456
>gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens]
Length = 1168
Score = 117 bits (292), Expect = 8e-26
Identities = 73/221 (33%), Positives = 124/221 (56%), Gaps = 18/221 (8%)
Query: 848 LLYQILPHSVAEQL----KRGETVQAEAFDSVTIYFSDIVGFTA----LSAESTPMQVVT 899
LL+ ILP VA +R + + ++ + V + F+ I F+ L A + ++ +
Sbjct: 947 LLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLR 1006
Query: 900 LLNDLYTCFDAVIDNF---DVYKVETIGDAYMVVSGLPVRN----GRLHACEVARMALAL 952
LLN++ FD +I + K++TIG YM SGL GR H +A A+ L
Sbjct: 1007 LLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRL 1066
Query: 953 LDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEAL 1012
++ ++ I +++IG++ GPV AGV+G + P+Y ++G+TVN +SRM+S G
Sbjct: 1067 MEQMK--HINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPD 1124
Query: 1013 KIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLG 1053
+I ++++ VL G++LE RG V++KGKG++ TY+L G
Sbjct: 1125 RIQVTTDLYQVLAA-KGYQLECRGVVKVKGKGEMTTYFLNG 1164
Score = 105 bits (263), Expect = 2e-22
Identities = 73/238 (30%), Positives = 125/238 (52%), Gaps = 33/238 (13%)
Query: 833 ERTQAYLE-------EKRKAEALLYQILPHSVAEQLKRGETVQAEAF----------DSV 875
+ T+ Y++ E R+ E LL +LP VA ++K + E D+V
Sbjct: 319 QETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNV 378
Query: 876 TIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLP- 934
+I F+DI GFT+L+++ T ++V LN+L+ FD + +++ +GD Y VSGLP
Sbjct: 379 SILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPE 438
Query: 935 VRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCL 994
R H C M + +++A+ +R + +R+GIH+G V GV+GL+ ++ +
Sbjct: 439 ARADHAHCC--VEMGVDMIEAIS--LVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDV 494
Query: 995 FGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMK-GKGKVRTYWL 1051
+ + V A+ ME+ G A +IH+ T+A L+ L GD E++ G+G R +L
Sbjct: 495 WSNDVTLANHMEAGGRAGRIHI---TRATLQ-------YLNGDYEVEPGRGGERNAYL 542
>gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens]
Length = 1115
Score = 117 bits (292), Expect = 8e-26
Identities = 73/221 (33%), Positives = 124/221 (56%), Gaps = 18/221 (8%)
Query: 848 LLYQILPHSVAEQL----KRGETVQAEAFDSVTIYFSDIVGFTA----LSAESTPMQVVT 899
LL+ ILP VA +R + + ++ + V + F+ I F+ L A + ++ +
Sbjct: 894 LLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLR 953
Query: 900 LLNDLYTCFDAVIDNF---DVYKVETIGDAYMVVSGLPVRN----GRLHACEVARMALAL 952
LLN++ FD +I + K++TIG YM SGL GR H +A A+ L
Sbjct: 954 LLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRL 1013
Query: 953 LDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEAL 1012
++ ++ I +++IG++ GPV AGV+G + P+Y ++G+TVN +SRM+S G
Sbjct: 1014 MEQMK--HINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPD 1071
Query: 1013 KIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLG 1053
+I ++++ VL G++LE RG V++KGKG++ TY+L G
Sbjct: 1072 RIQVTTDLYQVLAA-KGYQLECRGVVKVKGKGEMTTYFLNG 1111
Score = 105 bits (263), Expect = 2e-22
Identities = 73/238 (30%), Positives = 125/238 (52%), Gaps = 33/238 (13%)
Query: 833 ERTQAYLE-------EKRKAEALLYQILPHSVAEQLKRGETVQAEAF----------DSV 875
+ T+ Y++ E R+ E LL +LP VA ++K + E D+V
Sbjct: 319 QETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNV 378
Query: 876 TIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLP- 934
+I F+DI GFT+L+++ T ++V LN+L+ FD + +++ +GD Y VSGLP
Sbjct: 379 SILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPE 438
Query: 935 VRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCL 994
R H C M + +++A+ +R + +R+GIH+G V GV+GL+ ++ +
Sbjct: 439 ARADHAHCC--VEMGVDMIEAIS--LVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDV 494
Query: 995 FGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMK-GKGKVRTYWL 1051
+ + V A+ ME+ G A +IH+ T+A L+ L GD E++ G+G R +L
Sbjct: 495 WSNDVTLANHMEAGGRAGRIHI---TRATLQ-------YLNGDYEVEPGRGGERNAYL 542
>gi|34486092 adenylate cyclase 5 [Homo sapiens]
Length = 1261
Score = 116 bits (290), Expect = 1e-25
Identities = 79/236 (33%), Positives = 130/236 (55%), Gaps = 25/236 (10%)
Query: 840 EEKRKAEAL-------LYQILPHSVAEQL----KRGETVQAEAFDSVTIYFSDIVGFTA- 887
EEK + E L L+ ILP VA +R + + ++ + V + F+ I F+
Sbjct: 1024 EEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEF 1083
Query: 888 ---LSAESTPMQVVTLLNDLYTCFDAVI--DNF-DVYKVETIGDAYMVVSGLPVRN---- 937
L A + ++ + LLN++ FD +I D F + K++TIG YM SGL
Sbjct: 1084 YVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKV 1143
Query: 938 GRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGD 997
G+ H +A A+ L+D ++ I +++IG++ GPV AGV+G + P+Y ++G+
Sbjct: 1144 GKTHIKALADFAMKLMDQMKY--INEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGN 1201
Query: 998 TVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLG 1053
TVN ASRM+S G +I ++++ VL ++LE RG V++KGKG++ TY+L G
Sbjct: 1202 TVNVASRMDSTGVPDRIQVTTDMYQVLAA-NTYQLECRGVVKVKGKGEMMTYFLNG 1256
Score = 103 bits (257), Expect = 9e-22
Identities = 64/204 (31%), Positives = 111/204 (54%), Gaps = 17/204 (8%)
Query: 841 EKRKAEALLYQILPHSVAEQLKRGETVQAEAF----------DSVTIYFSDIVGFTALSA 890
E ++ E LL +LP VA ++K + E D+V+I F+DI GFT+L++
Sbjct: 424 ENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLAS 483
Query: 891 ESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLP-VRNGRLHACEVARMA 949
+ T ++V LN+L+ FD + +++ +GD Y VSGLP R H C M
Sbjct: 484 QCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCC--VEMG 541
Query: 950 LALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNG 1009
+ +++A+ +R + +R+GIH+G V GV+GL+ ++ ++ + V A+ ME+ G
Sbjct: 542 MDMIEAIS--LVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGG 599
Query: 1010 EALKIHLSSETKAVLEEFGGFELE 1033
+A +IH++ T L G +E+E
Sbjct: 600 KAGRIHITKATLNYLN--GDYEVE 621
>gi|24497587 adenylate cyclase 4 [Homo sapiens]
Length = 1077
Score = 114 bits (285), Expect = 5e-25
Identities = 82/264 (31%), Positives = 136/264 (51%), Gaps = 34/264 (12%)
Query: 816 LLSRMEQYANNLEELVEERTQAYLEEKRKAE----ALLYQILPHSVAEQL----KRGETV 867
+L+R +Y L+ L +++ + EE E LL +LP VA Q +R E +
Sbjct: 805 VLARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDL 864
Query: 868 QAEAFDSVTIYFSDIVGFTALSAEST----PMQVVTLLNDLYTCFDAVIDN---FDVYKV 920
++++ V + F+ + F +ES ++ + LLN++ FD ++ V K+
Sbjct: 865 YHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKI 924
Query: 921 ETIGDAYMVVSGLPVRNGR----------LHACEVARMALAL---LDAVRSFRIRHRPQE 967
+TIG YM +GL +G+ H + A+AL LD + +
Sbjct: 925 KTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNN---- 980
Query: 968 QLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEF 1027
RLR+G++ GPV AGV+G + P+Y ++G+TVN ASRMES G KI ++ ET L+
Sbjct: 981 -FRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSL 1039
Query: 1028 GGFELELRGDVEMKGKGKVRTYWL 1051
G+ RG +++KGKG++ TY+L
Sbjct: 1040 -GYTCYSRGVIKVKGKGQLCTYFL 1062
Score = 109 bits (272), Expect = 2e-23
Identities = 82/287 (28%), Positives = 137/287 (47%), Gaps = 30/287 (10%)
Query: 771 SHLEELGLLMQRCWAEDPQERPPF-QQIRLTLRKFNRENSSNILDNLLSRMEQYANNLEE 829
SHL LGL + P RP Q+ F N + + L A E
Sbjct: 151 SHLLVLGLYL----GPQPDSRPALLPQLAANAVLFLCGNVAGVYHKALMERALRATFREA 206
Query: 830 LVEERTQAYLE-EKRKAEALLYQILPHSVAEQLKRGETVQAEA----------------- 871
L ++ L+ EK+ E LL ILP +A ++K + +A
Sbjct: 207 LSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRPESTNNFHSLYV 266
Query: 872 --FDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMV 929
V++ ++DIVGFT L++E +P ++V +LN+L+ FD + + +++ +GD Y
Sbjct: 267 KRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYC 326
Query: 930 VSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKM 989
VSGLP+ HA RM L + A+R ++R + +R+G+H+G V GV+GL+
Sbjct: 327 VSGLPLSLPD-HAINCVRMGLDMCRAIR--KLRAATGVDINMRVGVHSGSVLCGVIGLQK 383
Query: 990 PRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRG 1036
+Y ++ V A+ ME+ G ++H++ T A+L G + +E G
Sbjct: 384 WQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLA--GAYAVEDAG 428
>gi|115387102 adenylate cyclase 2 [Homo sapiens]
Length = 1091
Score = 113 bits (282), Expect = 1e-24
Identities = 84/268 (31%), Positives = 133/268 (49%), Gaps = 28/268 (10%)
Query: 816 LLSRMEQYANNLEELVEERTQAYLEEKRKAE----ALLYQILPHSVAEQLK----RGETV 867
+L R +Y L+ L + + + EE E LL +LP VAE + E +
Sbjct: 819 VLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEEL 878
Query: 868 QAEAFDSVTIYFSDIVGFTALSAESTP----MQVVTLLNDLYTCFDAVIDN---FDVYKV 920
+++D V + F+ I F ES ++ + LLN++ FD ++ V K+
Sbjct: 879 YHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKI 938
Query: 921 ETIGDAYMVVSGLPVRNGRLHACEVARM----------ALALLDAVRSFRIRHRPQEQLR 970
+TIG YM +GL + H+ E R A AL+ + + I +
Sbjct: 939 KTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDA--INKHSFNDFK 996
Query: 971 LRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGF 1030
LR+GI+ GPV AGV+G + P+Y ++G+TVN ASRM+S G KI ++ ET VL+ G+
Sbjct: 997 LRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTL-GY 1055
Query: 1031 ELELRGDVEMKGKGKVRTYWLLGERGSS 1058
RG + +KGKG ++TY++ E S
Sbjct: 1056 TCTCRGIINVKGKGDLKTYFVNTEMSRS 1083
Score = 110 bits (274), Expect = 9e-24
Identities = 70/240 (29%), Positives = 128/240 (53%), Gaps = 31/240 (12%)
Query: 841 EKRKAEALLYQILPHSVAEQLKRGETVQ--------------------AEAFDSVTIYFS 880
EKR+ E LL +LP +A ++K E +Q + +V+I ++
Sbjct: 236 EKRQQERLLLSLLPAHIAMEMK-AEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYA 294
Query: 881 DIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRL 940
DIVGFT L+++ +P ++V +LN+L+ FD + + +++ +GD Y VSGLP+
Sbjct: 295 DIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPN- 353
Query: 941 HACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVN 1000
HA +M L + +A++ ++R + +R+G+H+G V GV+GL+ +Y ++ V
Sbjct: 354 HAKNCVKMGLDMCEAIK--KVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVT 411
Query: 1001 TASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKG----KGKVRTYWLLGERG 1056
A+ ME+ G ++H+SS T LE G GD +++ + V+TY+++ +G
Sbjct: 412 LANHMEAGGVPGRVHISSVT---LEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKG 468
>gi|31083193 adenylate cyclase 1 [Homo sapiens]
Length = 1119
Score = 110 bits (275), Expect = 7e-24
Identities = 67/204 (32%), Positives = 111/204 (54%), Gaps = 16/204 (7%)
Query: 840 EEKRKAEALLYQILPHSVAEQLKRG---------ETVQAEAFDSVTIYFSDIVGFTALSA 890
+E K E LL +LP +VA ++K + + D+V+I F+DIVGFT L++
Sbjct: 258 DENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTGLAS 317
Query: 891 ESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGL-PVRNGRLHACEVARMA 949
+ T ++V LLN+L+ FD + +++ +GD Y VSGL + H C M
Sbjct: 318 QCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCC--VEMG 375
Query: 950 LALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNG 1009
L ++D + S + + L +R+G+HTG V GV+GL+ +Y ++ + V A+ ME+ G
Sbjct: 376 LDMIDTITS--VAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAG 433
Query: 1010 EALKIHLSSETKAVLEEFGGFELE 1033
K+H++ T A L G +E+E
Sbjct: 434 LPGKVHITKTTLACLN--GDYEVE 455
Score = 107 bits (268), Expect = 5e-23
Identities = 74/249 (29%), Positives = 126/249 (50%), Gaps = 25/249 (10%)
Query: 823 YANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQL----KRGETVQAEAFDSVTIY 878
+A EE E+ + L+ +R +L+ +LP VA+ R + +++ V +
Sbjct: 815 WAAQAEEEREDMEKVKLDNRR----ILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVM 870
Query: 879 FSDIVGFT----ALSAESTPMQVVTLLNDLYTCFDAVIDNF---DVYKVETIGDAYMVVS 931
F+ I F L + ++ + LLN++ FD +++ D+ K++TIG YM
Sbjct: 871 FASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAV 930
Query: 932 GLPVRNGRL-------HACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGV 984
GL +G H +A A+ + D + I ++ LR+GI+ GPV AGV
Sbjct: 931 GLAPTSGTKAKKSISSHLSTLADFAIEMFDVLDE--INYQSYNDFVLRVGINVGPVVAGV 988
Query: 985 VGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKG 1044
+G + P+Y ++G+TVN ASRM+S G +I ++ E +L + RG V +KGKG
Sbjct: 989 IGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRC-PYHFVCRGKVSVKGKG 1047
Query: 1045 KVRTYWLLG 1053
++ TY+L G
Sbjct: 1048 EMLTYFLEG 1056
>gi|50959205 adenylate cyclase 9 [Homo sapiens]
Length = 1353
Score = 107 bits (266), Expect = 8e-23
Identities = 64/198 (32%), Positives = 107/198 (54%), Gaps = 12/198 (6%)
Query: 870 EAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMV 929
+ + V+I F+DIVGFT +SA + +V LLNDL+ FD + + K+ T+GD Y
Sbjct: 388 QQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYC 447
Query: 930 VSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKM 989
V+G P HA M L ++ A+ F +E + +R+G+HTG V G++G++
Sbjct: 448 VAGCPEPRAD-HAYCCIEMGLGMIKAIEQF--CQEKKEMVNMRVGVHTGTVLCGILGMRR 504
Query: 990 PRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKV--- 1046
++ ++ + VN A+ ME G A K+H+S T L++ +E+E +E G+ V
Sbjct: 505 FKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDD--RYEMEDGKVIERLGQSVVADQ 562
Query: 1047 ----RTYWLLGERGSSTR 1060
+TY + G+R +R
Sbjct: 563 LKGLKTYLISGQRAKESR 580
Score = 106 bits (264), Expect = 1e-22
Identities = 73/217 (33%), Positives = 117/217 (53%), Gaps = 14/217 (6%)
Query: 844 KAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTP--MQVVTLL 901
+A+ LL I+P+ VAEQLK +T ++ DS + F+ IV F+ E+ + +L
Sbjct: 1027 QADWLLRNIIPYHVAEQLKVSQTY-SKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVL 1085
Query: 902 NDLYTCFDAVIDNFD---VYKVETIGDAYMVVSGLPVRNGR------LHACEVARMALAL 952
N+L FD ++ D + K++TIG YM SGL + H + A +
Sbjct: 1086 NELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFAKEM 1145
Query: 953 LDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEAL 1012
+ V F + +LR+G + GP+ AGV+G Y ++GDTVN ASRM++ G
Sbjct: 1146 MRVVDDFN-NNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVEC 1204
Query: 1013 KIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTY 1049
+I +S E+ VL + G++ + RG V +KGKG+++TY
Sbjct: 1205 RIQVSEESYRVLSKM-GYDFDYRGTVNVKGKGQMKTY 1240
>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
Length = 455
Score = 99.8 bits (247), Expect = 1e-20
Identities = 96/313 (30%), Positives = 148/313 (47%), Gaps = 45/313 (14%)
Query: 564 VAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQD- 622
VAVK++ +IE ++L L H +Q F G +PPN I+TEY GSL D
Sbjct: 42 VAVKKL--LKIEKEAEILSVLSHRNIIQ------FYGVILEPPNYGIVTEYASLGSLYDY 93
Query: 623 ILENESITLDWMFRYSLTNDIVKGMLFLHNGAICS--HGNLKSSNCVVDGRFVLKITDYG 680
I N S +D + D+ KGM +LH A H +LKS N V+ VLKI D+G
Sbjct: 94 INSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFG 153
Query: 681 LESFRDLDPEQGHTVYAKKL----WTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRS 736
F + HT + + W APE+++ S PV S+ D YS+G++L E+ R
Sbjct: 154 ASRFHN------HTTHMSLVGTFPWMAPEVIQ--SLPV--SETCDTYSYGVVLWEMLTRE 203
Query: 737 GVFH-VEGLDLS--PKEIIERVTRGEQPPFRPSLALQSHLEELGLLMQRCWAEDPQERPP 793
F +EGL ++ E ER+T PS +S E L+ +CW D ++RP
Sbjct: 204 VPFKGLEGLQVAWLVVEKNERLT-------IPSSCPRSFAE----LLHQCWEADAKKRPS 252
Query: 794 FQQIRLTLRKFNRENS-SNILDNLLSRMEQYANNLEELVE-----ERTQAYLEEKRKAEA 847
F+QI L + + S + ++ L ++ +E +E ER ++ E++ K
Sbjct: 253 FKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQELKERE 312
Query: 848 LLYQILPHSVAEQ 860
++ + EQ
Sbjct: 313 RRLKMWEQKLTEQ 325
>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
Length = 800
Score = 99.8 bits (247), Expect = 1e-20
Identities = 96/313 (30%), Positives = 148/313 (47%), Gaps = 45/313 (14%)
Query: 564 VAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQD- 622
VAVK++ +IE ++L L H +Q F G +PPN I+TEY GSL D
Sbjct: 42 VAVKKL--LKIEKEAEILSVLSHRNIIQ------FYGVILEPPNYGIVTEYASLGSLYDY 93
Query: 623 ILENESITLDWMFRYSLTNDIVKGMLFLHNGAICS--HGNLKSSNCVVDGRFVLKITDYG 680
I N S +D + D+ KGM +LH A H +LKS N V+ VLKI D+G
Sbjct: 94 INSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFG 153
Query: 681 LESFRDLDPEQGHTVYAKKL----WTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRS 736
F + HT + + W APE+++ S PV S+ D YS+G++L E+ R
Sbjct: 154 ASRFHN------HTTHMSLVGTFPWMAPEVIQ--SLPV--SETCDTYSYGVVLWEMLTRE 203
Query: 737 GVFH-VEGLDLS--PKEIIERVTRGEQPPFRPSLALQSHLEELGLLMQRCWAEDPQERPP 793
F +EGL ++ E ER+T PS +S E L+ +CW D ++RP
Sbjct: 204 VPFKGLEGLQVAWLVVEKNERLT-------IPSSCPRSFAE----LLHQCWEADAKKRPS 252
Query: 794 FQQIRLTLRKFNRENS-SNILDNLLSRMEQYANNLEELVE-----ERTQAYLEEKRKAEA 847
F+QI L + + S + ++ L ++ +E +E ER ++ E++ K
Sbjct: 253 FKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQELKERE 312
Query: 848 LLYQILPHSVAEQ 860
++ + EQ
Sbjct: 313 RRLKMWEQKLTEQ 325
>gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo
sapiens]
Length = 859
Score = 92.8 bits (229), Expect = 2e-18
Identities = 78/249 (31%), Positives = 127/249 (51%), Gaps = 34/249 (13%)
Query: 559 YKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRG 618
+ G VAVK+V + ++KH+R +++ ++ F G CT P CIL E+C +G
Sbjct: 144 FHGEEVAVKKVRDLKET-------DIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQG 196
Query: 619 SLQDILE-----NESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFV 673
L ++L S+ +DW + I GM +LH I H +LKS N ++ V
Sbjct: 197 QLYEVLRAGRPVTPSLLVDW------SMGIAGGMNYLHLHKII-HRDLKSPNMLITYDDV 249
Query: 674 LKITDYGLESFRDLDPEQGHTVYAKKL-WTAPELLRMASPPVRGSQAGDVYSFGIILQEI 732
+KI+D+G + ++L + +A + W APE++R + PV S+ D++SFG++L E
Sbjct: 250 VKISDFG--TSKELSDKSTKMSFAGTVAWMAPEVIR--NEPV--SEKVDIWSFGVVLWE- 302
Query: 733 ALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLMQRCWAEDPQERP 792
L +G + +D S II V PS S + +L+++CW P+ RP
Sbjct: 303 -LLTGEIPYKDVDSS--AIIWGVGSNSLHLPVPS----SCPDGFKILLRQCWNSKPRNRP 355
Query: 793 PFQQIRLTL 801
F+QI L L
Sbjct: 356 SFRQILLHL 364
>gi|75677325 kinase suppressor of ras [Homo sapiens]
Length = 762
Score = 92.8 bits (229), Expect = 2e-18
Identities = 72/250 (28%), Positives = 120/250 (48%), Gaps = 23/250 (9%)
Query: 570 NRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESI 629
N+ ++L +K E+ + R ++E++ F+GAC +PP++ I+T +C +L + +
Sbjct: 510 NQDHLKLFKK---EVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKT 566
Query: 630 TLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDLDP 689
+LD + +I+KGM +LH I H +LKS N D V+ ITD+GL +
Sbjct: 567 SLDINKTRQIAQEIIKGMGYLHAKGIV-HKDLKSKNVFYDNGKVV-ITDFGLFGISGV-V 623
Query: 690 EQGHTVYAKKL------WTAPELLRMASP-----PVRGSQAGDVYSFGIILQEIALRSGV 738
+G KL + APE++R +P + S+A DVY+FG + E+ R
Sbjct: 624 REGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWP 683
Query: 739 FHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLMQRCWAEDPQERPPFQQIR 798
+ + S +I G + L S +E+ ++ CWA D QERP F +
Sbjct: 684 LKNQAAEASIWQI------GSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLM 737
Query: 799 LTLRKFNREN 808
L K + N
Sbjct: 738 DMLEKLPKLN 747
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 92.0 bits (227), Expect = 3e-18
Identities = 79/261 (30%), Positives = 124/261 (47%), Gaps = 21/261 (8%)
Query: 548 GQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPN 607
GQF Y K VAVK + + + L E M+ +Q++ L + T P
Sbjct: 271 GQFGEVWMATYNKHTKVAVKTMKPGSMSV-EAFLAEANVMKTLQHDKLVKLHAVVTKEP- 328
Query: 608 ICILTEYCPRGSLQDILENESITLDWMFRY-SLTNDIVKGMLFLHNGAICSHGNLKSSNC 666
I I+TE+ +GSL D L+++ + + + + I +GM F+ H +L+++N
Sbjct: 329 IYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYI-HRDLRAANI 387
Query: 667 VVDGRFVLKITDYGLESF---RDLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAGDVY 723
+V V KI D+GL + +G K WTAPE + S ++ DV+
Sbjct: 388 LVSASLVCKIADFGLARVIEDNEYTAREGAKFPIK--WTAPEAINFGSFTIKS----DVW 441
Query: 724 SFGIILQEIALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLMQRC 783
SFGI+L EI + + +S E+I + RG + P RP ++ EEL +M RC
Sbjct: 442 SFGILLMEIVTYGRIPYP---GMSNPEVIRALERGYRMP-RP----ENCPEELYNIMMRC 493
Query: 784 WAEDPQERPPFQQIRLTLRKF 804
W P+ERP F+ I+ L F
Sbjct: 494 WKNRPEERPTFEYIQSVLDDF 514
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 90.9 bits (224), Expect = 6e-18
Identities = 78/276 (28%), Positives = 131/276 (47%), Gaps = 27/276 (9%)
Query: 537 GSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLT 596
G YG + EG ++ ++ T VAVK + +E+ + L E M+++++ +L
Sbjct: 250 GGQYGEVY--EGVWKKYSLT-------VAVKTLKEDTMEV-EEFLKEAAVMKEIKHPNLV 299
Query: 597 RFVGACTDPPNICILTEYCPRGSLQDIL-ENESITLDWMFRYSLTNDIVKGMLFLHNGAI 655
+ +G CT P I+TE+ G+L D L E ++ + + I M +L
Sbjct: 300 QLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNF 359
Query: 656 CSHGNLKSSNCVVDGRFVLKITDYGLESFRDLDPEQGHTVYAKKL-WTAPELLRMASPPV 714
H +L + NC+V ++K+ D+GL D H + WTAPE L +
Sbjct: 360 I-HRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSI 418
Query: 715 RGSQAGDVYSFGIILQEIALRSGVFHVEGLDLSP-KEIIERVTRGEQPPFRPSLALQSHL 773
+ DV++FG++L EIA G+ G+DLS E++E+ R E+P P
Sbjct: 419 K----SDVWAFGVLLWEIA-TYGMSPYPGIDLSQVYELLEKDYRMERPEGCP-------- 465
Query: 774 EELGLLMQRCWAEDPQERPPFQQIRLTLRKFNRENS 809
E++ LM+ CW +P +RP F +I +E+S
Sbjct: 466 EKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESS 501
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,768,334
Number of Sequences: 37866
Number of extensions: 1922426
Number of successful extensions: 6214
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 166
Number of HSP's successfully gapped in prelim test: 405
Number of HSP's that attempted gapping in prelim test: 5295
Number of HSP's gapped (non-prelim): 739
length of query: 1061
length of database: 18,247,518
effective HSP length: 113
effective length of query: 948
effective length of database: 13,968,660
effective search space: 13242289680
effective search space used: 13242289680
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.