Search of human proteins with 110681710

Search of human proteins with 110681710

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|110681710 lactase-like [Homo sapiens]
         (567 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|110681710 lactase-like [Homo sapiens]                             1195   0.0  
gi|32481206 lactase-phlorizin hydrolase preproprotein [Homo sapi...   483   e-136
gi|13273313 cytosolic beta-glucosidase isoform a [Homo sapiens]       424   e-118
gi|24497614 klotho [Homo sapiens]                                     374   e-103
gi|28376633 klotho beta [Homo sapiens]                                363   e-100
gi|190360571 cytosolic beta-glucosidase isoform b [Homo sapiens]      115   1e-25
gi|151301096 trimethylguanosine synthase homolog [Homo sapiens]        31   2.7  
gi|13994322 TBC1 domain family, member 10A [Homo sapiens]              30   4.5  
gi|209870062 brain expressed, associated with Nedd4 [Homo sapiens]     30   4.5  

>gi|110681710 lactase-like [Homo sapiens]
          Length = 567

 Score = 1195 bits (3092), Expect = 0.0
 Identities = 567/567 (100%), Positives = 567/567 (100%)

Query: 1   MKPVWVATLLWMLLLVPRLGAARKGSPEEASFYYGTFPLGFSWGVGSSAYQTEGAWDQDG 60
           MKPVWVATLLWMLLLVPRLGAARKGSPEEASFYYGTFPLGFSWGVGSSAYQTEGAWDQDG
Sbjct: 1   MKPVWVATLLWMLLLVPRLGAARKGSPEEASFYYGTFPLGFSWGVGSSAYQTEGAWDQDG 60

Query: 61  KGPSIWDVFTHSGKGKVLGNETADVACDGYYKVQEDIILLRELHVNHYRFSLSWPRLLPT 120
           KGPSIWDVFTHSGKGKVLGNETADVACDGYYKVQEDIILLRELHVNHYRFSLSWPRLLPT
Sbjct: 61  KGPSIWDVFTHSGKGKVLGNETADVACDGYYKVQEDIILLRELHVNHYRFSLSWPRLLPT 120

Query: 121 GIRAEQVNKKGIEFYSDLIDALLSSNITPIVTLHHWDLPQLLQVKYGGWQNVSMANYFRD 180
           GIRAEQVNKKGIEFYSDLIDALLSSNITPIVTLHHWDLPQLLQVKYGGWQNVSMANYFRD
Sbjct: 121 GIRAEQVNKKGIEFYSDLIDALLSSNITPIVTLHHWDLPQLLQVKYGGWQNVSMANYFRD 180

Query: 181 YANLCFEAFGDRVKHWITFSDPRAMAEKGYETGHHAPGLKLRGTGLYKAAHHIIKAHAKA 240
           YANLCFEAFGDRVKHWITFSDPRAMAEKGYETGHHAPGLKLRGTGLYKAAHHIIKAHAKA
Sbjct: 181 YANLCFEAFGDRVKHWITFSDPRAMAEKGYETGHHAPGLKLRGTGLYKAAHHIIKAHAKA 240

Query: 241 WHSYNTTWRSKQQGLVGISLNCDWGEPVDISNPKDLEAAERYLQFCLGWFANPIYAGDYP 300
           WHSYNTTWRSKQQGLVGISLNCDWGEPVDISNPKDLEAAERYLQFCLGWFANPIYAGDYP
Sbjct: 241 WHSYNTTWRSKQQGLVGISLNCDWGEPVDISNPKDLEAAERYLQFCLGWFANPIYAGDYP 300

Query: 301 QVMKDYIGRKSAEQGLEMSRLPVFSLQEKSYIKGTSDFLGLGHFTTRYITERNYPSRQGP 360
           QVMKDYIGRKSAEQGLEMSRLPVFSLQEKSYIKGTSDFLGLGHFTTRYITERNYPSRQGP
Sbjct: 301 QVMKDYIGRKSAEQGLEMSRLPVFSLQEKSYIKGTSDFLGLGHFTTRYITERNYPSRQGP 360

Query: 361 SYQNDRDLIELVDPNWPDLGSKWLYSVPWGFRRLLNFAQTQYGDPPIYVMENGASQKFHC 420
           SYQNDRDLIELVDPNWPDLGSKWLYSVPWGFRRLLNFAQTQYGDPPIYVMENGASQKFHC
Sbjct: 361 SYQNDRDLIELVDPNWPDLGSKWLYSVPWGFRRLLNFAQTQYGDPPIYVMENGASQKFHC 420

Query: 421 TQLCDEWRIQYLKGYINEMLKAIKDGANIKGYTSWSLLDKFEWEKGYSDRYGFYYVEFND 480
           TQLCDEWRIQYLKGYINEMLKAIKDGANIKGYTSWSLLDKFEWEKGYSDRYGFYYVEFND
Sbjct: 421 TQLCDEWRIQYLKGYINEMLKAIKDGANIKGYTSWSLLDKFEWEKGYSDRYGFYYVEFND 480

Query: 481 RNKPRYPKASVQYYKKIIIANGFPNPREVESWYLKALETCSINNQMLAAEPLLSHMQMVT 540
           RNKPRYPKASVQYYKKIIIANGFPNPREVESWYLKALETCSINNQMLAAEPLLSHMQMVT
Sbjct: 481 RNKPRYPKASVQYYKKIIIANGFPNPREVESWYLKALETCSINNQMLAAEPLLSHMQMVT 540

Query: 541 EIVVPTVCSLCVLITAVLLMLLLRRQS 567
           EIVVPTVCSLCVLITAVLLMLLLRRQS
Sbjct: 541 EIVVPTVCSLCVLITAVLLMLLLRRQS 567


>gi|32481206 lactase-phlorizin hydrolase preproprotein [Homo sapiens]
          Length = 1927

 Score =  483 bits (1244), Expect = e-136
 Identities = 234/480 (48%), Positives = 320/480 (66%), Gaps = 7/480 (1%)

Query: 29   EASFYYGTFPLGFSWGVGSSAYQTEGAWDQDGKGPSIWDVFTHSGKGKVLGNETADVACD 88
            E  F YG FP GF W   S+AYQ EGAW  DGKG SIWD F+H+   +V  +   DVACD
Sbjct: 1369 EDEFLYGRFPEGFIWSAASAAYQIEGAWRADGKGLSIWDTFSHTPL-RVENDAIGDVACD 1427

Query: 89   GYYKVQEDIILLRELHVNHYRFSLSWPRLLPTGIRAEQVNKKGIEFYSDLIDALLSSNIT 148
             Y+K+ ED++ L+ L V+HYRFS+SW R+LP G     +N+ G+ +Y  LID LL+++I 
Sbjct: 1428 SYHKIAEDLVTLQNLGVSHYRFSISWSRILPDGT-TRYINEAGLNYYVRLIDTLLAASIQ 1486

Query: 149  PIVTLHHWDLPQLLQVKYGGWQNVSMANYFRDYANLCFEAFGDRVKHWITFSDPRAMAEK 208
            P VT++HWDLPQ LQ   GGW+N ++   F++YA++ F+  GD+VK WIT ++P  +A +
Sbjct: 1487 PQVTIYHWDLPQTLQ-DVGGWENETIVQRFKEYADVLFQRLGDKVKFWITLNEPFVIAYQ 1545

Query: 209  GYETGHHAPGLKLR-GTGLYKAAHHIIKAHAKAWHSYNTTWRSKQQGLVGISLNCDWGEP 267
            GY  G  APG+  R GT  Y   H++IKAHA+AWH YN  +R+ Q G++ I+++ DW EP
Sbjct: 1546 GYGYGTAAPGVSNRPGTAPYIVGHNLIKAHAEAWHLYNDVYRASQGGVISITISSDWAEP 1605

Query: 268  VDISNPKDLEAAERYLQFCLGWFANPIYA-GDYPQVMKDYIGRKSAEQGLEMSRLPVFSL 326
             D SN +D+EAA RY+QF  GWFA+PI+  GDY +VMK  I  +S   GL  SRLP F+ 
Sbjct: 1606 RDPSNQEDVEAARRYVQFMGGWFAHPIFKNGDYNEVMKTRIRDRSLAAGLNKSRLPEFTE 1665

Query: 327  QEKSYIKGTSDFLGLGHFTTRYITERNYPSRQGPSYQNDRDLIELVDPNWPDLGSKWLYS 386
             EK  I GT DF G  H+TT      NY +    S+  DR +  + D +WPD GS WL  
Sbjct: 1666 SEKRRINGTYDFFGFNHYTTVLAYNLNYATAIS-SFDADRGVASIADRSWPDSGSFWLKM 1724

Query: 387  VPWGFRRLLNFAQTQYGDPPIYVMENGASQKFHCTQLCDEWRIQYLKGYINEMLKAIKDG 446
             P+GFRR+LN+ + +Y DPPIYV ENG SQ+   T L D  RI YL+ YINE LKA++D 
Sbjct: 1725 TPFGFRRILNWLKEEYNDPPIYVTENGVSQREE-TDLNDTARIYYLRTYINEALKAVQDK 1783

Query: 447  ANIKGYTSWSLLDKFEWEKGYSDRYGFYYVEFNDRNKPRYPKASVQYYKKIIIANGFPNP 506
             +++GYT WS +D FEW  G+S+R+G ++V ++D + PR PKAS ++Y  ++  NGFP+P
Sbjct: 1784 VDLRGYTVWSAMDNFEWATGFSERFGLHFVNYSDPSLPRIPKASAKFYASVVRCNGFPDP 1843



 Score =  476 bits (1225), Expect = e-134
 Identities = 234/488 (47%), Positives = 322/488 (65%), Gaps = 9/488 (1%)

Query: 28   EEASFYYGTFPLGFSWGVGSSAYQTEGAWDQDGKGPSIWDVFTHSGKGKVLGNETADVAC 87
            E   FY+GTF   F WGV SSAYQ EGAWD DGKGPSIWD FTH+    V  N T D+AC
Sbjct: 894  ERDLFYHGTFRDDFLWGVSSSAYQIEGAWDADGKGPSIWDNFTHTPGSNVKDNATGDIAC 953

Query: 88   DGYYKVQEDIILLRELHVNHYRFSLSWPRLLPTGIRAEQVNKKGIEFYSDLIDALLSSNI 147
            D Y+++  D+ +LR L V  YRFS+SW R+ PTG R   +N  G+++Y+ LI+ L++SNI
Sbjct: 954  DSYHQLDADLNMLRALKVKAYRFSISWSRIFPTG-RNSSINSHGVDYYNRLINGLVASNI 1012

Query: 148  TPIVTLHHWDLPQLLQVKYGGWQNVSMANYFRDYANLCFEAFGDRVKHWITFSDPRAMAE 207
             P+VTL HWDLPQ LQ   GGW+N ++ + F  YA+ CF+ FGDRVK W+TF++P  +A 
Sbjct: 1013 FPMVTLFHWDLPQALQ-DIGGWENPALIDLFDSYADFCFQTFGDRVKFWMTFNEPMYLAW 1071

Query: 208  KGYETGHHAPGLKLRGTGLYKAAHHIIKAHAKAWHSYNTTWRSKQQGLVGISLNCDWGEP 267
             GY +G   PG+K  G   Y+ AH +IKAHA+ +H+Y+  +R +Q+G++ +SL+  W EP
Sbjct: 1072 LGYGSGEFPPGVKDPGWAPYRIAHAVIKAHARVYHTYDEKYRQEQKGVISLSLSTHWAEP 1131

Query: 268  VDISNPKDLEAAERYLQFCLGWFANPIYA-GDYPQVMKDYIGRKSAEQGLEMSRLPVFSL 326
                 P+D+EAA+R LQF LGWFA+PI+  GDYP  MK  +G +S  Q L  SRLP F+ 
Sbjct: 1132 KSPGVPRDVEAADRMLQFSLGWFAHPIFRNGDYPDTMKWKVGNRSELQHLATSRLPSFTE 1191

Query: 327  QEKSYIKGTSDFLGLGHFTTRYITERNYPSRQGPSYQNDRDLIELVDPNWPDLGSKWLYS 386
            +EK +I+ T+D   L  + +R I +   P    PSY++D+++ E  DP+WP        +
Sbjct: 1192 EEKRFIRATADVFCLNTYYSR-IVQHKTPRLNPPSYEDDQEMAEEEDPSWPSTAMN--RA 1248

Query: 387  VPWGFRRLLNFAQTQYGDPPIYVMENGASQKFHCTQLCDEWRIQYLKGYINEMLKAIK-D 445
             PWG RRLLN+ + +YGD PIY+ ENG       T+  D  RI Y K YINE LKA + D
Sbjct: 1249 APWGTRRLLNWIKEEYGDIPIYITENGVGLTNPNTE--DTDRIFYHKTYINEALKAYRLD 1306

Query: 446  GANIKGYTSWSLLDKFEWEKGYSDRYGFYYVEFNDRNKPRYPKASVQYYKKIIIANGFPN 505
            G +++GY +WSL+D FEW  GY+ ++G Y+V+FN+ N+PR  +AS +YY ++I  NG P 
Sbjct: 1307 GIDLRGYVAWSLMDNFEWLNGYTVKFGLYHVDFNNTNRPRTARASARYYTEVITNNGMPL 1366

Query: 506  PREVESWY 513
             RE E  Y
Sbjct: 1367 AREDEFLY 1374



 Score =  407 bits (1047), Expect = e-113
 Identities = 210/487 (43%), Positives = 283/487 (58%), Gaps = 11/487 (2%)

Query: 22  ARKGSPEEASFYYGTFPLGFSWGVGSSAYQTEGAWDQDGKGPSIWDVFTHSGKGKVLGNE 81
           A +   E  +F   TFP GF WG  + A+  EG W + G+G SIWD           G  
Sbjct: 367 ANQSRAERDAFLQDTFPEGFLWGASTGAFNVEGGWAEGGRGVSIWD--PRRPLNTTEGQA 424

Query: 82  TADVACDGYYKVQEDIILLRELHVNHYRFSLSWPRLLPTGIRAEQVNKKGIEFYSDLIDA 141
           T +VA D Y+KV  D+ LL  L    Y+FS+SW R+ P G      +  G+ +Y+ LID 
Sbjct: 425 TLEVASDSYHKVASDVALLCGLRAQVYKFSISWSRIFPMG-HGSSPSLPGVAYYNKLIDR 483

Query: 142 LLSSNITPIVTLHHWDLPQLLQVKYGGWQNVSMANYFRDYANLCFEAFGDRVKHWITFSD 201
           L  + I P+ TL HWDLPQ LQ  +GGWQN S+ + F DYA  CF  FGDRVK W+TF +
Sbjct: 484 LQDAGIEPMATLFHWDLPQALQ-DHGGWQNESVVDAFLDYAAFCFSTFGDRVKLWVTFHE 542

Query: 202 PRAMAEKGYETGHHAPGLKLRGTGLYKAAHHIIKAHAKAWHSYNTTWRSKQQGLVGISLN 261
           P  M+  GY TG H PG+   G   +K AH ++KAHA+ WH YN+  R +QQG VGI LN
Sbjct: 543 PWVMSYAGYGTGQHPPGISDPGVASFKVAHLVLKAHARTWHHYNSHHRPQQQGHVGIVLN 602

Query: 262 CDWGEPVDISNPKDLEAAERYLQFCLGWFANPIYA-GDYPQVMKDYIGRKSAEQGLEMSR 320
            DW EP+    P+DL A+ER+L F LGWFA+P++  GDYP  ++  I + + +    +++
Sbjct: 603 SDWAEPLSPERPEDLRASERFLHFMLGWFAHPVFVDGDYPATLRTQIQQMNRQCSHPVAQ 662

Query: 321 LPVFSLQEKSYIKGTSDFLGLGHFTTRYITERNYPSRQG-PSYQNDRDLIELVDPNWPDL 379
           LP F+  EK  +KG++DFLGL H+T+R I+  N P     PSY       + V+  WP  
Sbjct: 663 LPEFTEAEKQLLKGSADFLGLSHYTSRLIS--NAPQNTCIPSYDTIGGFSQHVNHVWPQT 720

Query: 380 GSKWLYSVPWGFRRLLNFAQTQY--GDPPIYVMENGASQKFHCTQLCDEWRIQYLKGYIN 437
            S W+  VPWG RRLL F   +Y  G  PIY+  NG           D  R+ Y   YIN
Sbjct: 721 SSSWIRVVPWGIRRLLQFVSLEYTRGKVPIYLAGNGMPIGESENLFDDSLRVDYFNQYIN 780

Query: 438 EMLKAIK-DGANIKGYTSWSLLDKFEWEKGYSDRYGFYYVEFNDRNKPRYPKASVQYYKK 496
           E+LKAIK D  +++ Y + SL+D FE   GYS R+G ++V F+D +K R P+ S  ++  
Sbjct: 781 EVLKAIKEDSVDVRSYIARSLIDGFEGPSGYSQRFGLHHVNFSDSSKSRTPRKSAYFFTS 840

Query: 497 IIIANGF 503
           II  NGF
Sbjct: 841 IIEKNGF 847



 Score = 69.3 bits (168), Expect = 9e-12
 Identities = 48/164 (29%), Positives = 79/164 (48%), Gaps = 18/164 (10%)

Query: 100 LRELHVNHYRFSLSWPRLLPTGIRAEQVNKKGIEFYSDLIDALLSSNITPIVTLHHWDLP 159
           L    + HY+  LSW +LLP G   +  ++K ++ Y  L+ AL ++ + P+V LHH  LP
Sbjct: 79  LHASQITHYKVFLSWAQLLPAG-STQNPDEKTVQCYRRLLKALKTARLQPMVILHHQTLP 137

Query: 160 QLLQVKYGGWQNVSMANYFRDYANLCFEAFGDRVKHWITFSDPRAMAEKGYETGHHAPGL 219
                +       + A+ F DYA   F +FGD V  W TFSD   + ++        P  
Sbjct: 138 ASTLRR-----TEAFADLFADYATFAFHSFGDLVGIWFTFSDLEEVIKE-------LPHQ 185

Query: 220 KLRGTGLYKAAHHIIKAHAKAWHSYNTTWRSKQQGLVGISLNCD 263
           + R + L      +  AH KA+  Y+ ++ + Q G + + L  +
Sbjct: 186 ESRASQL----QTLSDAHRKAYEIYHESY-AFQGGKLSVVLRAE 224


>gi|13273313 cytosolic beta-glucosidase isoform a [Homo sapiens]
          Length = 469

 Score =  424 bits (1089), Expect = e-118
 Identities = 213/469 (45%), Positives = 296/469 (63%), Gaps = 10/469 (2%)

Query: 37  FPLGFSWGVGSSAYQTEGAWDQDGKGPSIWDVFTHSGKGKVLGNETADVACDGYYKVQED 96
           FP GF W   ++AYQ EG WD DGKGP +WD FTH G  +V  N+T DVAC  Y   +ED
Sbjct: 3   FPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGERVFKNQTGDVACGSYTLWEED 62

Query: 97  IILLRELHVNHYRFSLSWPRLLPTGIRAEQVNKKGIEFYSDLIDALLSSNITPIVTLHHW 156
           +  +++L + HYRFSLSW RLLP G     +N+KGI++Y+ +ID LL + +TPIVTL+H+
Sbjct: 63  LKCIKQLGLTHYRFSLSWSRLLPDGTTGF-INQKGIDYYNKIIDDLLKNGVTPIVTLYHF 121

Query: 157 DLPQLLQVKYGGWQNVSMANYFRDYANLCFEAFGDRVKHWITFSDPRAMAEKGYETGHHA 216
           DLPQ L+ + GGW + ++   F  YA  CF  FGDRVK WIT ++   ++   Y+ G   
Sbjct: 122 DLPQTLEDQ-GGWLSEAIIESFDKYAQFCFSTFGDRVKQWITINEANVLSVMSYDLGMFP 180

Query: 217 PGLKLRGTGLYKAAHHIIKAHAKAWHSYNTTWRSKQQGLVGISLNCDWGEPVDISNPKDL 276
           PG+   GTG Y+AAH++IKAHA++WHSY++ +R KQ+G+V +SL   W EP D ++  D 
Sbjct: 181 PGIPHFGTGGYQAAHNLIKAHARSWHSYDSLFRKKQKGMVSLSLFAVWLEPADPNSVSDQ 240

Query: 277 EAAERYLQFCLGWFANPIYA-GDYPQVMKDYIGRKSAEQGLEMSRLPVFSLQEKSYIKGT 335
           EAA+R + F L  FA PI+  GDYP+V+K  I   S +QG   SRLP F+ +EK  IKGT
Sbjct: 241 EAAKRAITFHLDLFAKPIFIDGDYPEVVKSQIASMSQKQGYPSSRLPEFTEEEKKMIKGT 300

Query: 336 SDFLGLGHFTTRYIT-ERNYPSRQGPSYQNDRDLIELVDPNWPDLGSKWLYSVPWGFRRL 394
           +DF  + ++TTR I  + N     G     D ++    DP+W ++   W+Y VPWG  +L
Sbjct: 301 ADFFAVQYYTTRLIKYQENKKGELG--ILQDAEIEFFPDPSWKNV--DWIYVVPWGVCKL 356

Query: 395 LNFAQTQYGDPPIYVMENGASQKFHCTQLCDEWRIQYLKGYINEMLKAIK-DGANIKGYT 453
           L + +  Y +P IY+ ENG  Q      L D  R +Y +    E+ KAI+ D  N++ Y 
Sbjct: 357 LKYIKDTYNNPVIYITENGFPQS-DPAPLDDTQRWEYFRQTFQELFKAIQLDKVNLQVYC 415

Query: 454 SWSLLDKFEWEKGYSDRYGFYYVEFNDRNKPRYPKASVQYYKKIIIANG 502
           +WSLLD FEW +GYS R+G ++V+F D  +PR P  S + Y KII  NG
Sbjct: 416 AWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNG 464


>gi|24497614 klotho [Homo sapiens]
          Length = 1012

 Score =  374 bits (960), Expect = e-103
 Identities = 210/500 (42%), Positives = 286/500 (57%), Gaps = 55/500 (11%)

Query: 22  ARKGSPEEASFYYGTFPLGFSWGVGSSAYQTEGAWDQDGKGPSIWDVFTHS--------- 72
           +R  +PE A  + GTFP GF W VGS+AYQTEG W Q GKG SIWD FTH          
Sbjct: 46  SRPPAPEAAGLFQGTFPDGFLWAVGSAAYQTEGGWQQHGKGASIWDTFTHHPLAPPGDSR 105

Query: 73  ------GKGKVLGNETADVACDGYYKVQEDIILLRELHVNHYRFSLSWPRLLPTGIRAEQ 126
                 G    L   T DVA D Y  V  D   LREL V HYRFS+SW R+LP G  A  
Sbjct: 106 NASLPLGAPSPLQPATGDVASDSYNNVFRDTEALRELGVTHYRFSISWARVLPNG-SAGV 164

Query: 127 VNKKGIEFYSDLIDALLSSNITPIVTLHHWDLPQLLQVKYGGWQNVSMANYFRDYANLCF 186
            N++G+ +Y  L++ L    + P+VTL+HWDLPQ LQ  YGGW N ++A++FRDYA LCF
Sbjct: 165 PNREGLRYYRRLLERLRELGVQPVVTLYHWDLPQRLQDAYGGWANRALADHFRDYAELCF 224

Query: 187 EAFGDRVKHWITFSDPRAMAEKGYETGHHAPGLKLRGTGLYKAAHHIIKAHAKAWHSYNT 246
             FG +VK+WIT  +P  +A  GY TG  APG++      Y  AH+++ AHAK WH YNT
Sbjct: 225 RHFGGQVKYWITIDNPYVVAWHGYATGRLAPGIRGSPRLGYLVAHNLLLAHAKVWHLYNT 284

Query: 247 TWRSKQQGLVGISLNCDWGEPVDISNPKDLEAAERYLQFCLGWFANPIYA-GDYPQVMKD 305
           ++R  Q G V I+L+  W  P  +++   ++  ++ L F LGWFA P++  GDYP+ MK+
Sbjct: 285 SFRPTQGGQVSIALSSHWINPRRMTD-HSIKECQKSLDFVLGWFAKPVFIDGDYPESMKN 343

Query: 306 YIGRKSAEQGLEMSRLPVFSLQEKSYIKGTSDFLGLGHFTTRYITERNYPSRQGPSYQND 365
            +           S LP F+  EK +IKGT+DF  L                 GP+    
Sbjct: 344 NLS----------SILPDFTESEKKFIKGTADFFALCF---------------GPTLS-- 376

Query: 366 RDLIELVDPNWPDLGSKWLYSVPWGFRRLLNFAQTQYGDPPIYVMENGASQKFHCTQLCD 425
               +L+DP+      K+        R+LL++   ++  P I+++ENG       T+  D
Sbjct: 377 ---FQLLDPH-----MKFRQLESPNLRQLLSWIDLEFNHPQIFIVENGWFVS-GTTKRDD 427

Query: 426 EWRIQYLKGYINEMLKAIK-DGANIKGYTSWSLLDKFEWEKGYSDRYGFYYVEFNDRNKP 484
              + YLK +I E LKAIK DG ++ GYT+WSL+D FEW +GYS R G +YV+F  ++K 
Sbjct: 428 AKYMYYLKKFIMETLKAIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKM 487

Query: 485 RYPKASVQYYKKIIIANGFP 504
             PK+S  +Y+K+I  NGFP
Sbjct: 488 LLPKSSALFYQKLIEKNGFP 507



 Score =  288 bits (736), Expect = 1e-77
 Identities = 180/498 (36%), Positives = 265/498 (53%), Gaps = 54/498 (10%)

Query: 35  GTFPLGFSWGVGSSAYQTEGAWDQ-DGKGPSIWDVFTHSGKGKVLGNETADVA--CDGYY 91
           GTFP  F+WGV  +  Q +    Q       +WDV       KV G  T      C  + 
Sbjct: 517 GTFPCDFAWGVVDNYIQVDTTLSQFTDLNVYLWDVHHSKRLIKVDGVVTKKRKSYCVDFA 576

Query: 92  KVQEDIILLRELHVNHYRFSLSWPRLLPTGIRAEQVNKKGIEFYSDLIDALLSSNITPIV 151
            +Q  I LL+E+HV H+RFSL W  +LP G ++ QVN   +++Y  +   L+  NITP+V
Sbjct: 577 AIQPQIALLQEMHVTHFRFSLDWALILPLGNQS-QVNHTILQYYRCMASELVRVNITPVV 635

Query: 152 TLH-----HWDLPQLLQVKYGGWQNVSMANYFRDYANLCFEAFGDRVKHWITFSDPRAMA 206
            L      +  LP+LL  + G W+N   A  F +YA LCF+  G  VK WIT ++P    
Sbjct: 636 ALWQPMAPNQGLPRLL-ARQGAWENPYTALAFAEYARLCFQELGHHVKLWITMNEPYTR- 693

Query: 207 EKGYETGHHAPGLKLRGTGLYKAAHHIIKAHAKAWHSYNTTWRSKQQGLVGISLNCDWGE 266
                               Y A H+++KAHA AWH YN  +R  Q G + I+L  DW E
Sbjct: 694 -----------------NMTYSAGHNLLKAHALAWHVYNEKFRHAQNGKISIALQADWIE 736

Query: 267 PVDISNPKDLEAAERYLQFCLGWFANPIY-AGDYPQVMKDYIGRKSAEQGLEMSRLPVFS 325
           P    + KD E AER L+F +GW A PI+ +GDYP VM+D++ +++         LP F+
Sbjct: 737 PACPFSQKDKEVAERVLEFDIGWLAEPIFGSGDYPWVMRDWLNQRN------NFLLPYFT 790

Query: 326 LQEKSYIKGTSDFLGLGHFTTRYI-TERNYPSRQGPSYQNDRDLIELVDPNWPDLGSKWL 384
             EK  I+GT DFL L H+TT  + +E+  P +    Y +  ++ E+ D  W +  S+ +
Sbjct: 791 EDEKKLIQGTFDFLALSHYTTILVDSEKEDPIK----YNDYLEVQEMTDITWLNSPSQ-V 845

Query: 385 YSVPWGFRRLLNFAQTQYGDPPIYVMENGASQKFHCTQLCDEWRIQYLKGYINEMLKA-I 443
             VPWG R++LN+ + +YGD P+Y++ NG     H     D+ R+ Y++ YINE LKA I
Sbjct: 846 AVVPWGLRKVLNWLKFKYGDLPMYIISNGIDDGLHAED--DQLRVYYMQNYINEALKAHI 903

Query: 444 KDGANIKGYTSWSLLDKFEWEKGYSDRYGFYYVEFNDRNKPRYPKASVQYYKKIIIANGF 503
            DG N+ GY ++S  D+       + R+G Y    +       PKAS+++Y+KII +NGF
Sbjct: 904 LDGINLCGYFAYSFNDR------TAPRFGLYRYAADQFE----PKASMKHYRKIIDSNGF 953

Query: 504 PNPREVESWYLKALETCS 521
           P P  +E +  +    C+
Sbjct: 954 PGPETLERFCPEEFTVCT 971


>gi|28376633 klotho beta [Homo sapiens]
          Length = 1044

 Score =  363 bits (932), Expect = e-100
 Identities = 197/478 (41%), Positives = 276/478 (57%), Gaps = 43/478 (8%)

Query: 28  EEASFYYGTFPLGFSWGVGSSAYQTEGAWDQDGKGPSIWDVFTHSGKGKVLGNETADVAC 87
           E   F Y TFP  F WG+G+ A Q EG+W +DGKGPSIWD F H+    V    + + + 
Sbjct: 72  ESQLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNV---SSTNGSS 128

Query: 88  DGYYKVQEDIILLRELHVNHYRFSLSWPRLLPTGIRAEQVNKKGIEFYSDLIDALLSSNI 147
           D Y  +++D+  L  + V+ Y+FS+SWPRL P GI     N KG+++YS L+DAL+  NI
Sbjct: 129 DSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGI-VTVANAKGLQYYSTLLDALVLRNI 187

Query: 148 TPIVTLHHWDLPQLLQVKYGGWQNVSMANYFRDYANLCFEAFGDRVKHWITFSDPRAMAE 207
            PIVTL+HWDLP  LQ KYGGW+N ++ + F DYA  CF+ FGDRVK+WIT  +P  +A 
Sbjct: 188 EPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAW 247

Query: 208 KGYETGHHAPGLKLRGTGLYKAAHHIIKAHAKAWHSYNTTWRSKQQGLVGISLNCDWGEP 267
            GY TG HAPG K     +Y   H++IKAH+K WH+YNT +R  Q+G + I+L   W EP
Sbjct: 248 HGYGTGMHAPGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEP 307

Query: 268 VDISNPKDLEAAERYLQFCLGWFANPIYA-GDYPQVMKDYIGRKSAEQGLEMSRLPVFSL 326
               N  D+   ++ +   LGWFANPI+  GDYP+ M+  +           S LP+FS 
Sbjct: 308 NRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKL----------FSVLPIFSE 357

Query: 327 QEKSYIKGTSDFLGLGHFTTRYITERNYPSRQGPSYQNDRDLIELVDPNWPDLGSKWLYS 386
            EK  ++GT+DF                    GP+  N + L  +         +K   +
Sbjct: 358 AEKHEMRGTADFFAFSF---------------GPN--NFKPLNTM---------AKMGQN 391

Query: 387 VPWGFRRLLNFAQTQYGDPPIYVMENGASQKFHCTQLCDEWRIQYLKGYINEMLKAIK-D 445
           V    R  LN+ + +Y +P I + ENG        +  D   I  +K +++++L+AI+ D
Sbjct: 392 VSLNLREALNWIKLEYNNPRILIAENGWFTDSR-VKTEDTTAIYMMKNFLSQVLQAIRLD 450

Query: 446 GANIKGYTSWSLLDKFEWEKGYSDRYGFYYVEFNDRNKPRYPKASVQYYKKIIIANGF 503
              + GYT+WSLLD FEW+  Y+ R G +YV+FN + K R PK+S  YYK+II  NGF
Sbjct: 451 EIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGF 508



 Score =  259 bits (662), Expect = 5e-69
 Identities = 166/482 (34%), Positives = 248/482 (51%), Gaps = 44/482 (9%)

Query: 35  GTFPLGFSWGVGSSAYQTEG-AWDQDGKGPS--IWDVFTHSGKGKVLGN--ETADVACDG 89
           G FP  FSWGV  S  + E  A       P   +W+   +    +V G   +T    C  
Sbjct: 519 GQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTD 578

Query: 90  YYKVQEDIILLRELHVNHYRFSLSWPRLLPTGIRAEQVNKKGIEFYSDLIDALLSSNITP 149
           +  +++ + +L  + V HYRF+L W  +LPTG     VN++ + +Y  ++   L   I+ 
Sbjct: 579 FVNIKKQLEMLARMKVTHYRFALDWASVLPTG-NLSAVNRQALRYYRCVVSEGLKLGISA 637

Query: 150 IVTLH-----HWDLPQLLQVKYGGWQNVSMANYFRDYANLCFEAFGDRVKHWITFSDPRA 204
           +VTL+     H  LP+ L +   GW N S A  F+ YA LCF+  GD VK WIT ++P  
Sbjct: 638 MVTLYYPTHAHLGLPEPL-LHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNR 696

Query: 205 MAEKGYETGHHAPGLKLRGTGLYKAAHHIIKAHAKAWHSYNTTWRSKQQGLVGISLNCDW 264
           +++    +G+            Y AAH+++ AHA AW  Y+  +R  Q+G V +SL+ DW
Sbjct: 697 LSDIYNRSGNDT----------YGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADW 746

Query: 265 GEPVDISNPKDLEAAERYLQFCLGWFANPIY-AGDYPQVMKDYIGRKSAEQGLEMSRLPV 323
            EP +        AAER+LQF + WFA P++  GDYP  M++YI  K   +GL  S LP 
Sbjct: 747 AEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKH-RRGLSSSALPR 805

Query: 324 FSLQEKSYIKGTSDFLGLGHFTTRYITERNYPSRQGPSYQNDRDLIELVDPNWPDLGSKW 383
            +  E+  +KGT DF  L HFTTR++    +    G  Y +DRD+  L D       ++ 
Sbjct: 806 LTEAERRLLKGTVDFCALNHFTTRFVM---HEQLAGSRYDSDRDIQFLQDITRLSSPTR- 861

Query: 384 LYSVPWGFRRLLNFAQTQYGDPPIYVMENGASQKFHCTQLCDEWRIQYLKGYINEMLKA- 442
           L  +PWG R+LL + +  YGD  IY+  +G   +       D  R  YL  Y+ E+LKA 
Sbjct: 862 LAVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQ---ALEDDRLRKYYLGKYLQEVLKAY 918

Query: 443 IKDGANIKGYTSWSLLDKFEWEKGYSDRYGFYYVEFNDRNKPRYPKASVQYYKKIIIANG 502
           + D   IKGY ++ L      E+    R+GF+  +F         K+S+Q+Y K+I + G
Sbjct: 919 LIDKVRIKGYYAFKLA-----EEKSKPRFGFFTSDFK-------AKSSIQFYNKVISSRG 966

Query: 503 FP 504
           FP
Sbjct: 967 FP 968


>gi|190360571 cytosolic beta-glucosidase isoform b [Homo sapiens]
          Length = 162

 Score =  115 bits (287), Expect = 1e-25
 Identities = 51/105 (48%), Positives = 67/105 (63%), Gaps = 6/105 (5%)

Query: 37  FPLGFSWGVGSSAYQTEGAWDQDGKGPSIWDVFTHSGKGKVLGNETADVACDGYYKVQED 96
           FP GF W   ++AYQ EG WD DGKGP +WD FTH G  +V  N+T DVAC  Y   +ED
Sbjct: 3   FPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGERVFKNQTGDVACGSYTLWEED 62

Query: 97  IILLRELHVNHYRFSLSWPRLLPTGI------RAEQVNKKGIEFY 135
           +  +++L + HYRFSLSW RLLP G       +A Q++K  ++ Y
Sbjct: 63  LKCIKQLGLTHYRFSLSWSRLLPDGTTGFINQKAIQLDKVNLQVY 107



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 35/70 (50%), Positives = 48/70 (68%), Gaps = 3/70 (4%)

Query: 434 GYINEMLKAIK-DGANIKGYTSWSLLDKFEWEKGYSDRYGFYYVEFNDRNKPRYPKASVQ 492
           G+IN+  KAI+ D  N++ Y +WSLLD FEW +GYS R+G ++V+F D  +PR P  S +
Sbjct: 90  GFINQ--KAIQLDKVNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAK 147

Query: 493 YYKKIIIANG 502
            Y KII  NG
Sbjct: 148 EYAKIIRNNG 157


>gi|151301096 trimethylguanosine synthase homolog [Homo sapiens]
          Length = 853

 Score = 31.2 bits (69), Expect = 2.7
 Identities = 22/80 (27%), Positives = 38/80 (47%), Gaps = 5/80 (6%)

Query: 400 TQYGDPPIYVMENGASQKFHCTQLCDEWRIQYLKGYINEMLKAIKDGANIKGYTSWSLLD 459
           T+  +PP+   EN  S K   T+  +++  +Y  G + +  +    G  +     W+  D
Sbjct: 177 TETENPPV---ENTLSPKLEITEKWEKYWNEYGGGLLWQSWQEKHPGQALSS-EPWNFPD 232

Query: 460 -KFEWEKGYSDRYGFYYVEF 478
            K EWE+ YS  Y +Y  +F
Sbjct: 233 TKEEWEQHYSQLYWYYLEQF 252


>gi|13994322 TBC1 domain family, member 10A [Homo sapiens]
          Length = 508

 Score = 30.4 bits (67), Expect = 4.5
 Identities = 22/65 (33%), Positives = 33/65 (50%), Gaps = 9/65 (13%)

Query: 397 FAQTQYGDPPIYVMENGASQKFHC-TQLCDEWRIQYLKGYINEMLKAIKDGANIKGYTSW 455
           + Q Q     + +M   A Q F C  Q+C++    YL GY +E L+AI+    + G   +
Sbjct: 195 YCQAQAPIAAVLLMHMPAEQAFWCLVQICEK----YLPGYYSEKLEAIQ----LDGEILF 246

Query: 456 SLLDK 460
           SLL K
Sbjct: 247 SLLQK 251


>gi|209870062 brain expressed, associated with Nedd4 [Homo sapiens]
          Length = 150

 Score = 30.4 bits (67), Expect = 4.5
 Identities = 26/98 (26%), Positives = 44/98 (44%), Gaps = 13/98 (13%)

Query: 263 DWGEPVDISNPKDLEAAERYLQFCLGWFANPIYAGDYPQVMKDYIGRKSAEQGLEMSRLP 322
           DW  P+DIS+  D++A               +Y  D P   ++ +G  + +  +     P
Sbjct: 10  DWPPPLDISSDGDVDAT----------VLRELYP-DSPPGYEECVGPGATQLYVPTDAPP 58

Query: 323 VFSLQEK-SYIKGTSDFLGLGHFTTRYITERNYPSRQG 359
            +SL +    + GTSD  G GH   R+  E+  P++ G
Sbjct: 59  PYSLTDSCPTLDGTSD-SGSGHSPGRHQQEQRTPAQGG 95


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.138    0.445 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,077,666
Number of Sequences: 37866
Number of extensions: 1064900
Number of successful extensions: 2023
Number of sequences better than 10.0: 9
Number of HSP's better than 10.0 without gapping: 6
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 1949
Number of HSP's gapped (non-prelim): 15
length of query: 567
length of database: 18,247,518
effective HSP length: 108
effective length of query: 459
effective length of database: 14,157,990
effective search space: 6498517410
effective search space used: 6498517410
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.