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Search of human proteins with 166235129
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|166235129 kelch-like 3 [Homo sapiens]
(587 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|166235129 kelch-like 3 [Homo sapiens] 1177 0.0
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 929 0.0
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 929 0.0
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 835 0.0
gi|38194229 kelch-like 17 [Homo sapiens] 516 e-146
gi|40807500 kelch-like 20 [Homo sapiens] 468 e-132
gi|11056006 kelch-like 12 [Homo sapiens] 441 e-124
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 438 e-123
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 438 e-123
gi|14780904 kelch-like 1 protein [Homo sapiens] 422 e-118
gi|55925604 kelch-like 18 [Homo sapiens] 416 e-116
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 412 e-115
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 404 e-112
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 401 e-111
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 387 e-107
gi|34101268 kelch-like 8 [Homo sapiens] 379 e-105
gi|148664209 kelch-like 10 [Homo sapiens] 360 2e-99
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 351 1e-96
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 351 1e-96
gi|40018614 DRE1 protein [Homo sapiens] 320 2e-87
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 313 3e-85
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 312 5e-85
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens] 306 4e-83
gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 294 1e-79
gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain contai... 294 1e-79
gi|223890235 intracisternal A particle-promoted polypeptide isof... 292 7e-79
gi|45643138 kelch-like 13 [Homo sapiens] 268 1e-71
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens] 267 2e-71
gi|109150407 kelch-like 6 [Homo sapiens] 261 1e-69
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo... 261 2e-69
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 1177 bits (3045), Expect = 0.0
Identities = 587/587 (100%), Positives = 587/587 (100%)
Query: 1 MEGESVKLSSQTLIQAGDDEKNQRTITVNPAHMGKAFKVMNELRSKQLLCDVMIVAEDVE 60
MEGESVKLSSQTLIQAGDDEKNQRTITVNPAHMGKAFKVMNELRSKQLLCDVMIVAEDVE
Sbjct: 1 MEGESVKLSSQTLIQAGDDEKNQRTITVNPAHMGKAFKVMNELRSKQLLCDVMIVAEDVE 60
Query: 61 IEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENV 120
IEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENV
Sbjct: 61 IEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENV 120
Query: 121 QVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFP 180
QVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFP
Sbjct: 121 QVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFP 180
Query: 181 EVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWINYEKETRLEHMAKLMEHVR 240
EVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWINYEKETRLEHMAKLMEHVR
Sbjct: 181 EVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWINYEKETRLEHMAKLMEHVR 240
Query: 241 LPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLP 300
LPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLP
Sbjct: 241 LPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLP 300
Query: 301 KVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLR 360
KVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLR
Sbjct: 301 KVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLR 360
Query: 361 VRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNE 420
VRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNE
Sbjct: 361 VRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNE 420
Query: 421 WFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRR 480
WFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRR
Sbjct: 421 WFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRR 480
Query: 481 SGAGVGVLSGQLYATGGHDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLY 540
SGAGVGVLSGQLYATGGHDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLY
Sbjct: 481 SGAGVGVLSGQLYATGGHDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLY 540
Query: 541 VVGGDDGSCNLASVEYYNPVTDKWTLLPTNMSTGRSYAGVAVIHKSL 587
VVGGDDGSCNLASVEYYNPVTDKWTLLPTNMSTGRSYAGVAVIHKSL
Sbjct: 541 VVGGDDGSCNLASVEYYNPVTDKWTLLPTNMSTGRSYAGVAVIHKSL 587
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 929 bits (2401), Expect = 0.0
Identities = 449/570 (78%), Positives = 513/570 (90%)
Query: 18 DDEKNQRTITVNPAHMGKAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCA 77
D+ + +TVNP HM KAFKVMNELRS+ LLCDV IVAED+EI AHRVVLAACSPYF A
Sbjct: 28 DNTEKHCPVTVNPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHA 87
Query: 78 MFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQ 137
MFTG+MSES+AK++ IK+VDG TL LIDY+YTAEI+VTEENVQVLLPAA LLQL DV++
Sbjct: 88 MFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKK 147
Query: 138 NCCDFLQSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVC 197
CC+FL+SQLHP NCLGIRAFAD+H CTDLL +AN YAEQHF +V+L EEFL+L ++QVC
Sbjct: 148 TCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVC 207
Query: 198 SLISSDKLTVSSEEKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEA 257
SLISSDKLT+SSEEKVFEAVI+W+N++K+ R E MA+LMEHVRLPLLPR+YLVQ VEEEA
Sbjct: 208 SLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEA 267
Query: 258 LIKNNNTCKDFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSV 317
L+KN++ CKD+LIEAMKYHLLP +QR+L+K+ RT+ RTP++LPK+M+VVGGQAPKAIRSV
Sbjct: 268 LVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSV 327
Query: 318 ECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSI 377
ECYDF+E+RW Q+AELPSRRCRAG+V+MAG V+AVGGFNGSLRVRTVD YD VKDQWTS+
Sbjct: 328 ECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSV 387
Query: 378 ASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVG 437
A+M++RRSTLGAAVLN LLYAVGGFDGSTGL+SVEAY+ K+NEWF VAPMNTRRSSVGVG
Sbjct: 388 ANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVG 447
Query: 438 VVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGG 497
VV G LYAVGGYDGASRQCLSTVE YN TNEW Y+A+MSTRRSGAGVGVL+ LYA GG
Sbjct: 448 VVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG 507
Query: 498 HDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYY 557
HDGPLVRKSVEVYDP TN W+QVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYY
Sbjct: 508 HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYY 567
Query: 558 NPVTDKWTLLPTNMSTGRSYAGVAVIHKSL 587
NP TDKWT++ + MSTGRSYAGV VI K L
Sbjct: 568 NPTTDKWTVVSSCMSTGRSYAGVTVIDKPL 597
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 929 bits (2401), Expect = 0.0
Identities = 449/570 (78%), Positives = 513/570 (90%)
Query: 18 DDEKNQRTITVNPAHMGKAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCA 77
D+ + +TVNP HM KAFKVMNELRS+ LLCDV IVAED+EI AHRVVLAACSPYF A
Sbjct: 24 DNTEKHCPVTVNPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHA 83
Query: 78 MFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQ 137
MFTG+MSES+AK++ IK+VDG TL LIDY+YTAEI+VTEENVQVLLPAA LLQL DV++
Sbjct: 84 MFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKK 143
Query: 138 NCCDFLQSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVC 197
CC+FL+SQLHP NCLGIRAFAD+H CTDLL +AN YAEQHF +V+L EEFL+L ++QVC
Sbjct: 144 TCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVC 203
Query: 198 SLISSDKLTVSSEEKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEA 257
SLISSDKLT+SSEEKVFEAVI+W+N++K+ R E MA+LMEHVRLPLLPR+YLVQ VEEEA
Sbjct: 204 SLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEA 263
Query: 258 LIKNNNTCKDFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSV 317
L+KN++ CKD+LIEAMKYHLLP +QR+L+K+ RT+ RTP++LPK+M+VVGGQAPKAIRSV
Sbjct: 264 LVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSV 323
Query: 318 ECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSI 377
ECYDF+E+RW Q+AELPSRRCRAG+V+MAG V+AVGGFNGSLRVRTVD YD VKDQWTS+
Sbjct: 324 ECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSV 383
Query: 378 ASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVG 437
A+M++RRSTLGAAVLN LLYAVGGFDGSTGL+SVEAY+ K+NEWF VAPMNTRRSSVGVG
Sbjct: 384 ANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVG 443
Query: 438 VVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGG 497
VV G LYAVGGYDGASRQCLSTVE YN TNEW Y+A+MSTRRSGAGVGVL+ LYA GG
Sbjct: 444 VVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG 503
Query: 498 HDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYY 557
HDGPLVRKSVEVYDP TN W+QVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYY
Sbjct: 504 HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYY 563
Query: 558 NPVTDKWTLLPTNMSTGRSYAGVAVIHKSL 587
NP TDKWT++ + MSTGRSYAGV VI K L
Sbjct: 564 NPTTDKWTVVSSCMSTGRSYAGVTVIDKPL 593
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 835 bits (2157), Expect = 0.0
Identities = 401/505 (79%), Positives = 459/505 (90%)
Query: 83 MSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDF 142
MSES+AK++ IK+VDG TL LIDY+YTAEI+VTEENVQVLLPAA LLQL DV++ CC+F
Sbjct: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
Query: 143 LQSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISS 202
L+SQLHP NCLGIRAFAD+H CTDLL +AN YAEQHF +V+L EEFL+L ++QVCSLISS
Sbjct: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
Query: 203 DKLTVSSEEKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNN 262
DKLT+SSEEKVFEAVI+W+N++K+ R E MA+LMEHVRLPLLPR+YLVQ VEEEAL+KN+
Sbjct: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
Query: 263 NTCKDFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECYDF 322
+ CKD+LIEAMKYHLLP +QR+L+K+ RT+ RTP++LPK+M+VVGGQAPKAIRSVECYDF
Sbjct: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDF 240
Query: 323 EEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQE 382
+E+RW Q+AELPSRRCRAG+V+MAG V+AVGGFNGSLRVRTVD YD VKDQWTS+A+M++
Sbjct: 241 KEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRD 300
Query: 383 RRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGK 442
RRSTLGAAVLN LLYAVGGFDGSTGL+SVEAY+ K+NEWF VAPMNTRRSSVGVGVV G
Sbjct: 301 RRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGL 360
Query: 443 LYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPL 502
LYAVGGYDGASRQCLSTVE YN TNEW Y+A+MSTRRSGAGVGVL+ LYA GGHDGPL
Sbjct: 361 LYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL 420
Query: 503 VRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTD 562
VRKSVEVYDP TN W+QVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNP TD
Sbjct: 421 VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTD 480
Query: 563 KWTLLPTNMSTGRSYAGVAVIHKSL 587
KWT++ + MSTGRSYAGV VI K L
Sbjct: 481 KWTVVSSCMSTGRSYAGVTVIDKPL 505
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 516 bits (1329), Expect = e-146
Identities = 274/553 (49%), Positives = 361/553 (65%), Gaps = 5/553 (0%)
Query: 32 HMGKAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKI 91
H AF M+ +R + LLCD+++ EI AH+VVLA+CSPYF AMFT +MSES+ +
Sbjct: 74 HYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHV 133
Query: 92 EIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTN 151
+ D+D Q L +L+ + YTAEI V E NVQ LLPAASLLQL VR CC FL SQL P+N
Sbjct: 134 TLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSN 193
Query: 152 CLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEE 211
CLGIR FAD H+C+DLL+ A+ Y QHF +V EEF+ L L QV L+SSD L V SEE
Sbjct: 194 CLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEE 253
Query: 212 KVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIE 271
+V+ AV+SW+ ++ + R +H+ +LM+ VRLPLL RD+L+ V+ E+L++++ CKD LIE
Sbjct: 254 EVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIE 313
Query: 272 AMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIR-SVECYDFEEDRWDQI 330
A+K+HLLP +QR ++ RT+PR V+ VGG + AI E YD DRW +
Sbjct: 314 ALKFHLLP-EQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVV 372
Query: 331 AELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAA 390
A + +RR R GV + +YAVGG++G+ + TV+ YD V + W SM RRS LG A
Sbjct: 373 ASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVA 432
Query: 391 VLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYD 450
L+ LLY+ GG+DG++ L S E Y T W VA M+TRR V V ++G LYAVGGYD
Sbjct: 433 ALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYD 492
Query: 451 GASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVEVY 510
+S L+TVE+Y P N W VA M +RRS AGV VL G LY GG+DG SVE Y
Sbjct: 493 SSSH--LATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERY 550
Query: 511 DPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKWTLLPTN 570
P W+ VA MN+ R + A++G LY VGG+DGS +L S+E YNP T+KW + +
Sbjct: 551 SPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKW-VAASC 609
Query: 571 MSTGRSYAGVAVI 583
M T RS GVAV+
Sbjct: 610 MFTRRSSVGVAVL 622
Score = 102 bits (253), Expect = 1e-21
Identities = 56/139 (40%), Positives = 82/139 (58%), Gaps = 1/139 (0%)
Query: 303 MIVVGG-QAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRV 361
+ VGG + + +VE Y+ + + W +A + SRR AGV + G +Y GG +G+ +
Sbjct: 485 LYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCL 544
Query: 362 RTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEW 421
+V+ Y W S+A M RRST ++ LYAVGG DGS+ L S+E Y+ +TN+W
Sbjct: 545 NSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKW 604
Query: 422 FFVAPMNTRRSSVGVGVVE 440
+ M TRRSSVGV V+E
Sbjct: 605 VAASCMFTRRSSVGVAVLE 623
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 468 bits (1203), Expect = e-132
Identities = 252/558 (45%), Positives = 352/558 (63%), Gaps = 6/558 (1%)
Query: 28 VNPAHMGKAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESK 87
++ H + +V+N LR + LCDV++V +I AHRV+L+ACSPYF AMFTG+++ES+
Sbjct: 46 ISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESR 105
Query: 88 AKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQL 147
++ I+D+D + + LID+ YT++I V E NVQ LLPAA LLQL ++++ CC+FL+ QL
Sbjct: 106 QTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQL 165
Query: 148 HPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTV 207
P+NCLGIRAFAD H+C +LL+ A+ + + +F EVM EEF+ L +Q+ +ISSD+L V
Sbjct: 166 DPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNV 225
Query: 208 SSEEKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKD 267
SEE+VF AV++W+ Y + R + ++++HVRLPLL +LV TV + LIK++ C+D
Sbjct: 226 RSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRD 285
Query: 268 FLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQ-APKAIRSVECYDFEEDR 326
+ EA Y LLP +R L++ PRT+PR P+ +V+ VGG + AI SVE YD + +
Sbjct: 286 LVDEAKNYLLLP-QERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNE 344
Query: 327 WDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTS-IASMQERRS 385
W +A + RRC GV + +YAVGG +GS + +V+ YD +QW+S +A R+
Sbjct: 345 WRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRT 404
Query: 386 TLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYA 445
++G AVL LYAVGG DG + L VE Y K N+W VA M+TRR V V V+ G LYA
Sbjct: 405 SVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYA 464
Query: 446 VGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRK 505
VGG DG S L+TVE+YNP N W +A M TRR G V +YA GG D
Sbjct: 465 VGGSDGTSP--LNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELS 522
Query: 506 SVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKWT 565
S E Y+P TN W V M R G+ VNG L VGG DG+ L ++E ++P + W
Sbjct: 523 SAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWR 582
Query: 566 LLPTNMSTGRSYAGVAVI 583
L M+ R GV VI
Sbjct: 583 LY-GGMNYRRLGGGVGVI 599
Score = 97.1 bits (240), Expect = 4e-20
Identities = 50/136 (36%), Positives = 76/136 (55%)
Query: 305 VVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTV 364
V G + +VE Y+ +E+RW IA + +RR G +YAVGG + + + +
Sbjct: 465 VGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSA 524
Query: 365 DVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFV 424
+ Y+ +QW+ + +M RRS +G AV+N L AVGGFDG+T L ++E + N W
Sbjct: 525 ERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLY 584
Query: 425 APMNTRRSSVGVGVVE 440
MN RR GVGV++
Sbjct: 585 GGMNYRRLGGGVGVIK 600
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 441 bits (1135), Expect = e-124
Identities = 232/561 (41%), Positives = 335/561 (59%), Gaps = 15/561 (2%)
Query: 32 HMGKAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKI 91
H MN LR LCDV + E + AHR+VLAACS YFCAMFT ++SE +
Sbjct: 15 HAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYV 74
Query: 92 EIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTN 151
+I+ + T+ L+D++YT + VT ENVQ LLPAA LLQL V+Q CC+FL+SQL P+N
Sbjct: 75 DIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSN 134
Query: 152 CLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEE 211
CLGIR FA+ H C DL+Q A ++++HFPEV+ EEF+ LS +V LI D++ V SEE
Sbjct: 135 CLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEE 194
Query: 212 KVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIE 271
VFEAVI+W+ + K+ R E + L+++VR+PLL Y+ ++ E I+ + C+D + E
Sbjct: 195 PVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDE 254
Query: 272 AMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGG----QAPKAIRSVECYDFEEDRW 327
A K+HL P + R ++ PRT+ R + +V++VVGG Q+P I VE YD + W
Sbjct: 255 AKKFHLRP-ELRSQMQGPRTRAR--LGANEVLLVVGGFGSQQSP--IDVVEKYDPKTQEW 309
Query: 328 DQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQ---WTSIASMQERR 384
+ + +R V + +Y +GG++G R+ +V+ D D+ W S+A M RR
Sbjct: 310 SFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRR 369
Query: 385 STLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLY 444
GA L D++Y GGFDGS S+E Y ++W + M T R G+ V G +Y
Sbjct: 370 GLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIY 429
Query: 445 AVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVR 504
+GGYDG + L++VE+Y+P T W V M+T+RSGAGV +L+ +Y GG DG
Sbjct: 430 CLGGYDGLN--ILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHL 487
Query: 505 KSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKW 564
SVE Y+ T++W V M R G + G LY + G DG+ L+S+E Y+P+ D W
Sbjct: 488 SSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSW 547
Query: 565 TLLPTNMSTGRSYAGVAVIHK 585
++ T+M T R AGV V+ +
Sbjct: 548 EVV-TSMGTQRCDAGVCVLRE 567
Score = 100 bits (248), Expect = 5e-21
Identities = 48/129 (37%), Positives = 73/129 (56%)
Query: 314 IRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQ 373
+ SVE YD W + + ++R AGV + H+Y VGGF+G+ + +V+ Y+ D
Sbjct: 440 LNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDS 499
Query: 374 WTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSS 433
WT++ SM R +GA VL LYA+ G+DG++ L+S+E Y + W V M T+R
Sbjct: 500 WTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQRCD 559
Query: 434 VGVGVVEGK 442
GV V+ K
Sbjct: 560 AGVCVLREK 568
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 438 bits (1126), Expect = e-123
Identities = 238/560 (42%), Positives = 345/560 (61%), Gaps = 16/560 (2%)
Query: 32 HMGKAFKVM-NELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKK 90
H + FK M N LR KQL CDV++VA D I AHR+VL++ S YF AMFT D+ E++ ++
Sbjct: 156 HAEQTFKKMENYLRHKQL-CDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEE 214
Query: 91 IEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPT 150
I+++ V+ +L LI Y YT +E+ E+N++ LL A LLQL V + CC FL QLHP+
Sbjct: 215 IKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPS 274
Query: 151 NCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSE 210
NCLGIR+FAD CTDL + A+ Y +HF EV+ +EF+ L ++ L++SD + + +E
Sbjct: 275 NCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNE 334
Query: 211 EKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLI 270
E + A+++W+ ++ E R + ++KL+ ++RLPLL +L +E L +++ C+ ++
Sbjct: 335 ETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIECQKLIM 393
Query: 271 EAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGG-QAPKAIRSVECYDFEEDRWDQ 329
EAMKYHLLP ++R ++++PRTKPR S + VGG + K S+E YD + W
Sbjct: 394 EAMKYHLLP-ERRPMLQSPRTKPRK--STVGTLFAVGGMDSTKGATSIEKYDLRTNMWTP 450
Query: 330 IAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGA 389
+A + RR + GV + +Y VGG +G + TV+ Y+ W+ + M R LG
Sbjct: 451 VANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGV 510
Query: 390 AVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGY 449
AVL +YAVGG DG + L +VE + + +W FVA M+T RS+VGV V+ GKLYAVGG
Sbjct: 511 AVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGR 570
Query: 450 DGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPL------V 503
DG+S CL +VE ++P TN+W A MS RR G GV +G LYA GGHD P +
Sbjct: 571 DGSS--CLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRL 628
Query: 504 RKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDK 563
VE YDP T+ W VA M++ R GVC + LY VGG DG L +VE Y+P T++
Sbjct: 629 SDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNE 688
Query: 564 WTLLPTNMSTGRSYAGVAVI 583
WT + + GR+ A V +
Sbjct: 689 WTQV-APLCLGRAGACVVTV 707
Score = 102 bits (254), Expect = 1e-21
Identities = 59/161 (36%), Positives = 83/161 (51%), Gaps = 6/161 (3%)
Query: 286 IKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFM 345
+ PR+ V K+ V G ++SVEC+D ++W A++ RR GV
Sbjct: 548 MSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTW 607
Query: 346 AGHVYAVGGFNGSLRVRT------VDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAV 399
G +YA+GG + T V+ YD D WT++ASM R +G +L D LYAV
Sbjct: 608 NGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAV 667
Query: 400 GGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVE 440
GG+DG L +VEAY +TNEW VAP+ R+ V V+
Sbjct: 668 GGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVK 708
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 438 bits (1126), Expect = e-123
Identities = 238/560 (42%), Positives = 345/560 (61%), Gaps = 16/560 (2%)
Query: 32 HMGKAFKVM-NELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKK 90
H + FK M N LR KQL CDV++VA D I AHR+VL++ S YF AMFT D+ E++ ++
Sbjct: 202 HAEQTFKKMENYLRHKQL-CDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEE 260
Query: 91 IEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPT 150
I+++ V+ +L LI Y YT +E+ E+N++ LL A LLQL V + CC FL QLHP+
Sbjct: 261 IKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPS 320
Query: 151 NCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSE 210
NCLGIR+FAD CTDL + A+ Y +HF EV+ +EF+ L ++ L++SD + + +E
Sbjct: 321 NCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNE 380
Query: 211 EKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLI 270
E + A+++W+ ++ E R + ++KL+ ++RLPLL +L +E L +++ C+ ++
Sbjct: 381 ETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIECQKLIM 439
Query: 271 EAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGG-QAPKAIRSVECYDFEEDRWDQ 329
EAMKYHLLP ++R ++++PRTKPR S + VGG + K S+E YD + W
Sbjct: 440 EAMKYHLLP-ERRPMLQSPRTKPRK--STVGTLFAVGGMDSTKGATSIEKYDLRTNMWTP 496
Query: 330 IAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGA 389
+A + RR + GV + +Y VGG +G + TV+ Y+ W+ + M R LG
Sbjct: 497 VANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGV 556
Query: 390 AVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGY 449
AVL +YAVGG DG + L +VE + + +W FVA M+T RS+VGV V+ GKLYAVGG
Sbjct: 557 AVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGR 616
Query: 450 DGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPL------V 503
DG+S CL +VE ++P TN+W A MS RR G GV +G LYA GGHD P +
Sbjct: 617 DGSS--CLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRL 674
Query: 504 RKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDK 563
VE YDP T+ W VA M++ R GVC + LY VGG DG L +VE Y+P T++
Sbjct: 675 SDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNE 734
Query: 564 WTLLPTNMSTGRSYAGVAVI 583
WT + + GR+ A V +
Sbjct: 735 WTQV-APLCLGRAGACVVTV 753
Score = 102 bits (254), Expect = 1e-21
Identities = 59/161 (36%), Positives = 83/161 (51%), Gaps = 6/161 (3%)
Query: 286 IKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFM 345
+ PR+ V K+ V G ++SVEC+D ++W A++ RR GV
Sbjct: 594 MSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTW 653
Query: 346 AGHVYAVGGFNGSLRVRT------VDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAV 399
G +YA+GG + T V+ YD D WT++ASM R +G +L D LYAV
Sbjct: 654 NGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAV 713
Query: 400 GGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVE 440
GG+DG L +VEAY +TNEW VAP+ R+ V V+
Sbjct: 714 GGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVK 754
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 422 bits (1086), Expect = e-118
Identities = 228/559 (40%), Positives = 338/559 (60%), Gaps = 14/559 (2%)
Query: 32 HMGKAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKI 91
H + F+ M +Q LCDV+++ + +I AHR+VL++ S YF AMFT D+ E+K ++I
Sbjct: 194 HAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEI 253
Query: 92 EIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTN 151
+++ +D L L+ + YT +E+ E+ ++ LL AA LLQL V + CC FL LHP+N
Sbjct: 254 KMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSN 313
Query: 152 CLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEE 211
CLGIRAFAD C +L++ A++Y ++ EV+ +EFL L +++ L++SD + V EE
Sbjct: 314 CLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEE 373
Query: 212 KVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIE 271
+F A++ W+ Y+ ++R ++ L+ +RLPLLP L +E AL KN+ C+ ++E
Sbjct: 374 TIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILAD-LENHALFKNDLECQKLILE 432
Query: 272 AMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGG-QAPKAIRSVECYDFEEDRWDQI 330
AMKYHLLP ++R L+++PRTKPR S + VGG K ++E YD + W Q
Sbjct: 433 AMKYHLLP-ERRTLMQSPRTKPRK--STVGTLYAVGGMDNNKGATTIEKYDLRTNLWIQA 489
Query: 331 AELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAA 390
+ RR + GV + ++ +GG +G + TV+ Y+ WT + M R LG
Sbjct: 490 GMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVT 549
Query: 391 VLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYD 450
VL +YAVGG DG + L +VE + ++ +W FVA M+ RS+VGV + GKLY+VGG D
Sbjct: 550 VLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRD 609
Query: 451 GASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPL------VR 504
G+S CLS++E Y+P TN+W A M RR G GV G LYA GGHD P +
Sbjct: 610 GSS--CLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLL 667
Query: 505 KSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKW 564
VE YDP T+TW VA ++M R GVC + LY VGG DG L ++E Y+P T++W
Sbjct: 668 DYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEW 727
Query: 565 TLLPTNMSTGRSYAGVAVI 583
T + +++ GR+ A V VI
Sbjct: 728 TQM-ASLNIGRAGACVVVI 745
Score = 91.3 bits (225), Expect = 2e-18
Identities = 52/146 (35%), Positives = 77/146 (52%), Gaps = 6/146 (4%)
Query: 301 KVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNG--- 357
K+ V G + S+E YD ++W+ A + RR GV G +YAVGG +
Sbjct: 601 KLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPAS 660
Query: 358 ---SLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAY 414
S + V+ YD D WT +A + R +G +L D LYAVGG+DG T L ++E+Y
Sbjct: 661 NHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESY 720
Query: 415 SYKTNEWFFVAPMNTRRSSVGVGVVE 440
+TNEW +A +N R+ V V++
Sbjct: 721 DPQTNEWTQMASLNIGRAGACVVVIK 746
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 416 bits (1070), Expect = e-116
Identities = 213/535 (39%), Positives = 320/535 (59%), Gaps = 5/535 (0%)
Query: 35 KAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIK 94
+ + VM E+R + LCDV + D + AHR+VLAA PYF AMFT DM E K +I ++
Sbjct: 23 RGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQ 82
Query: 95 DVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLG 154
+D L LI++ Y + + ++NVQ LL AS LQL ++ CC FL+ +LHP NCLG
Sbjct: 83 GMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLG 142
Query: 155 IRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVF 214
+R FA+ C L AN++ QHF EV + EEFL+L L+ V L+S D+L V SEE+VF
Sbjct: 143 VRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVF 202
Query: 215 EAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMK 274
EA ++W+ Y++E R ++ +L+ ++RLPL +L V+++ L++ + C+D + EA
Sbjct: 203 EAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKD 262
Query: 275 YHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGG--QAPKAIRSVECYDFEEDRWDQIAE 332
YHL+P ++R + RT+PR S+ ++ VGG A ++ VE +D + W++
Sbjct: 263 YHLMP-ERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRP 321
Query: 333 LPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVL 392
+ + R R GV + G +YA+GG++G LR+ TV+ Y+ D WT + SM +RS +G VL
Sbjct: 322 MTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVL 381
Query: 393 NDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGA 452
+ +Y GG+DG++ L+SVE YS +T++W V M++ RS+ GV V EG++Y GG+DG
Sbjct: 382 DGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGL 441
Query: 453 SRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVEVYDP 512
Q S+VE YN T W A M +R G L +++ GG+DG E+Y
Sbjct: 442 --QIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSS 499
Query: 513 GTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKWTLL 567
+ W + M+ R + A G LY VGG DG NL+SVE Y+P TD WT +
Sbjct: 500 VADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFM 554
Score = 132 bits (333), Expect = 7e-31
Identities = 73/203 (35%), Positives = 107/203 (52%), Gaps = 2/203 (0%)
Query: 286 IKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFM 345
+ + R+ T V ++ + G ++ SVE Y E D+W + + S R AGV
Sbjct: 369 MNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVF 428
Query: 346 AGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGS 405
G +Y GG +G +V+ Y+ W A M +R GAA L ++ GG+DGS
Sbjct: 429 EGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGS 488
Query: 406 TGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNP 465
L+ E YS ++W + PM+TRRS V + G+LYAVGGYDG S LS+VE Y+P
Sbjct: 489 GFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSN--LSSVEMYDP 546
Query: 466 ATNEWIYVADMSTRRSGAGVGVL 488
T+ W ++A M+ G GVG +
Sbjct: 547 ETDCWTFMAPMACHEGGVGVGCI 569
Score = 128 bits (322), Expect = 1e-29
Identities = 68/144 (47%), Positives = 93/144 (64%), Gaps = 2/144 (1%)
Query: 439 VEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGH 498
+ G +YAVGG + A L+ VE ++P N W M+T RS GV V++G LYA GG+
Sbjct: 286 IAGLIYAVGGLNSAG-DSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGY 344
Query: 499 DGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYN 558
DG L +VE Y+P T+TW +V MN R G ++G +YV GG DG+ +L+SVE Y+
Sbjct: 345 DGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYS 404
Query: 559 PVTDKWTLLPTNMSTGRSYAGVAV 582
P TDKWT++ T+MS+ RS AGV V
Sbjct: 405 PETDKWTVV-TSMSSNRSAAGVTV 427
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 412 bits (1058), Expect = e-115
Identities = 219/526 (41%), Positives = 323/526 (61%), Gaps = 14/526 (2%)
Query: 65 RVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLL 124
R+VL++ S YF AMFT D+ E++ ++I+++ V+ +L LI Y YT +E+ E+N++ LL
Sbjct: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
Query: 125 PAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVML 184
A LLQL V + CC FL QLHP+NCLGIR+FAD CTDL + A+ Y +HF EV+
Sbjct: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
Query: 185 GEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWINYEKETRLEHMAKLMEHVRLPLL 244
+EF+ L ++ L++SD + + +EE + A+++W+ ++ E R + ++KL+ ++RLPLL
Sbjct: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353
Query: 245 PRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMI 304
+L +E L +++ C+ ++EAMKYHLLP ++R ++++PRTKPR S +
Sbjct: 354 APQFLAD-MENNVLFRDDIECQKLIMEAMKYHLLP-ERRPMLQSPRTKPRK--STVGTLF 409
Query: 305 VVGG-QAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRT 363
VGG + K S+E YD + W +A + RR + GV + +Y VGG +G + T
Sbjct: 410 AVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNT 469
Query: 364 VDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFF 423
V+ Y+ W+ + M R LG AVL +YAVGG DG + L +VE + + +W F
Sbjct: 470 VECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNF 529
Query: 424 VAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGA 483
VA M+T RS+VGV V+ GKLYAVGG DG+S CL +VE ++P TN+W A MS RR G
Sbjct: 530 VATMSTPRSTVGVAVLSGKLYAVGGRDGSS--CLKSVECFDPHTNKWTLCAQMSKRRGGV 587
Query: 484 GVGVLSGQLYATGGHDGPL------VRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNG 537
GV +G LYA GGHD P + VE YDP T+ W VA M++ R GVC +
Sbjct: 588 GVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGD 647
Query: 538 LLYVVGGDDGSCNLASVEYYNPVTDKWTLLPTNMSTGRSYAGVAVI 583
LY VGG DG L +VE Y+P T++WT + + GR+ A V +
Sbjct: 648 KLYAVGGYDGQAYLNTVEAYDPQTNEWTQV-APLCLGRAGACVVTV 692
Score = 102 bits (254), Expect = 1e-21
Identities = 59/161 (36%), Positives = 83/161 (51%), Gaps = 6/161 (3%)
Query: 286 IKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFM 345
+ PR+ V K+ V G ++SVEC+D ++W A++ RR GV
Sbjct: 533 MSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTW 592
Query: 346 AGHVYAVGGFNGSLRVRT------VDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAV 399
G +YA+GG + T V+ YD D WT++ASM R +G +L D LYAV
Sbjct: 593 NGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAV 652
Query: 400 GGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVE 440
GG+DG L +VEAY +TNEW VAP+ R+ V V+
Sbjct: 653 GGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVK 693
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 404 bits (1037), Expect = e-112
Identities = 224/554 (40%), Positives = 331/554 (59%), Gaps = 17/554 (3%)
Query: 38 KVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVD 97
K+ N L+ KQL CDV+++A + I AHR+VL+A S YF AMFT D+ E+K +++ ++ VD
Sbjct: 171 KMENYLKEKQL-CDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVD 229
Query: 98 GQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRA 157
L+ L+ Y YT +++ E+ ++ LL AA LLQL V C +FL QLHP+NCLGIR+
Sbjct: 230 PNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRS 289
Query: 158 FADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAV 217
F D CT+LL A+ Y +HF EV+ +EFL L +++ L+ SD + V EE +F A+
Sbjct: 290 FGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHAL 349
Query: 218 ISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHL 277
+ W+ ++ + R + L+ ++RLPLLP L+ +E ++ + C+ L+EAMKYHL
Sbjct: 350 MQWVGHDVQNRQGELGMLLSYIRLPLLP-PQLLADLETSSMFTGDLECQKLLMEAMKYHL 408
Query: 278 LPLDQRLLIKNPRTKPRTPVSLPKVMIVVGG-QAPKAIRSVECYDFEEDRWDQIAELPSR 336
LP ++R ++++PRTKPR S + VGG A K ++E YD + W I + R
Sbjct: 409 LP-ERRSMMQSPRTKPRK--STVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGR 465
Query: 337 RCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLL 396
R + GV + +Y VGG +G + TV+ ++ V WT + M R LG A L +
Sbjct: 466 RLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPM 525
Query: 397 YAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQC 456
YAVGG DG + L +VE + + +W +VA M+T RS+VGV + KLYA+GG DG+S C
Sbjct: 526 YAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSS--C 583
Query: 457 LSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPL------VRKSVEVY 510
L ++E ++P TN+W A MS RR G GV +G LY GGHD P + VE Y
Sbjct: 584 LKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERY 643
Query: 511 DPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKW-TLLPT 569
DP ++W VA +++ R VC + LYVVGG DG L +VE Y+ ++W +P
Sbjct: 644 DPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPV 703
Query: 570 NMSTGRSYAGVAVI 583
N+ GR+ A V V+
Sbjct: 704 NI--GRAGACVVVV 715
Score = 99.8 bits (247), Expect = 6e-21
Identities = 54/147 (36%), Positives = 81/147 (55%), Gaps = 3/147 (2%)
Query: 441 GKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDG 500
G LYAVGG D + + +T+E+Y+ TN W+++ M+ RR GV V+ +LY GG DG
Sbjct: 429 GALYAVGGMD--AMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDG 486
Query: 501 PLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPV 560
+VE ++P W + M+ R GV + G +Y VGG DG L +VE ++P
Sbjct: 487 LKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPE 546
Query: 561 TDKWTLLPTNMSTGRSYAGVAVIHKSL 587
+W + +MST RS GV ++ L
Sbjct: 547 GRQWNYV-ASMSTPRSTVGVVALNNKL 572
Score = 82.0 bits (201), Expect = 1e-15
Identities = 49/151 (32%), Positives = 75/151 (49%), Gaps = 7/151 (4%)
Query: 297 VSLPKVMIVVGGQ-APKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGF 355
V+L + +GG+ ++S+E +D ++W A + RR GV G +Y VGG
Sbjct: 566 VALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGH 625
Query: 356 NG------SLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLA 409
+ S V+ YD D W+++A + R + L D LY VGG+DG T L
Sbjct: 626 DAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLN 685
Query: 410 SVEAYSYKTNEWFFVAPMNTRRSSVGVGVVE 440
+VE+Y + NEW P+N R+ V VV+
Sbjct: 686 TVESYDAQRNEWKEEVPVNIGRAGACVVVVK 716
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 401 bits (1030), Expect = e-111
Identities = 217/534 (40%), Positives = 320/534 (59%), Gaps = 14/534 (2%)
Query: 38 KVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVD 97
K+ N L+ KQL CDV+++A + I AHR+VL+A S YF AMFT D+ E+K +++ ++ VD
Sbjct: 171 KMENYLKEKQL-CDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVD 229
Query: 98 GQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRA 157
L+ L+ Y YT +++ E+ ++ LL AA LLQL V C +FL QLHP+NCLGIR+
Sbjct: 230 PNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRS 289
Query: 158 FADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAV 217
F D CT+LL A+ Y +HF EV+ +EFL L +++ L+ SD + V EE +F A+
Sbjct: 290 FGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHAL 349
Query: 218 ISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHL 277
+ W+ ++ + R + L+ ++RLPLLP L+ +E ++ + C+ L+EAMKYHL
Sbjct: 350 MQWVGHDVQNRQGELGMLLSYIRLPLLP-PQLLADLETSSMFTGDLECQKLLMEAMKYHL 408
Query: 278 LPLDQRLLIKNPRTKPRTPVSLPKVMIVVGG-QAPKAIRSVECYDFEEDRWDQIAELPSR 336
LP ++R ++++PRTKPR S + VGG A K ++E YD + W I + R
Sbjct: 409 LP-ERRSMMQSPRTKPRK--STVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGR 465
Query: 337 RCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLL 396
R + GV + +Y VGG +G + TV+ ++ V WT + M R LG A L +
Sbjct: 466 RLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPM 525
Query: 397 YAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQC 456
YAVGG DG + L +VE + + +W +VA M+T RS+VGV + KLYA+GG DG+S C
Sbjct: 526 YAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSS--C 583
Query: 457 LSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPL------VRKSVEVY 510
L ++E ++P TN+W A MS RR G GV +G LY GGHD P + VE Y
Sbjct: 584 LKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERY 643
Query: 511 DPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKW 564
DP ++W VA +++ R VC + LYVVGG DG L +VE Y+ ++W
Sbjct: 644 DPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEW 697
Score = 167 bits (422), Expect = 3e-41
Identities = 91/199 (45%), Positives = 114/199 (57%), Gaps = 9/199 (4%)
Query: 383 RRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGK 442
R+ST+GA LYAVGG D G ++E Y +TN W + MN RR GV V++ K
Sbjct: 424 RKSTVGA------LYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNK 477
Query: 443 LYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPL 502
LY VGG DG + L+TVE +NP W + MST R G GV L G +YA GGHDG
Sbjct: 478 LYVVGGRDGL--KTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWS 535
Query: 503 VRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTD 562
+VE +DP W VA M+ R GV A+N LY +GG DGS L S+EY++P T+
Sbjct: 536 YLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTN 595
Query: 563 KWTLLPTNMSTGRSYAGVA 581
KW+L MS R GVA
Sbjct: 596 KWSLC-APMSKRRGGVGVA 613
Score = 99.8 bits (247), Expect = 6e-21
Identities = 54/147 (36%), Positives = 81/147 (55%), Gaps = 3/147 (2%)
Query: 441 GKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDG 500
G LYAVGG D + + +T+E+Y+ TN W+++ M+ RR GV V+ +LY GG DG
Sbjct: 429 GALYAVGGMD--AMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDG 486
Query: 501 PLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPV 560
+VE ++P W + M+ R GV + G +Y VGG DG L +VE ++P
Sbjct: 487 LKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPE 546
Query: 561 TDKWTLLPTNMSTGRSYAGVAVIHKSL 587
+W + +MST RS GV ++ L
Sbjct: 547 GRQWNYV-ASMSTPRSTVGVVALNNKL 572
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 387 bits (995), Expect = e-107
Identities = 214/547 (39%), Positives = 317/547 (57%), Gaps = 24/547 (4%)
Query: 32 HMGKAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKI 91
H + + +N LR LCD+++ DV+I AH+VVLA+ SPYF AMFTG++SE + ++
Sbjct: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEV 76
Query: 92 EIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTN 151
E + +D L +++Y YT + ++++ V+ LLPAA+LLQ+ V + CC FL+SQL P N
Sbjct: 77 EFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGN 136
Query: 152 CLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEE 211
C+GI FA+ + C DL A Y Q+F V EEF L+ + ++S+D L V++EE
Sbjct: 137 CIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEE 196
Query: 212 KVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIE 271
VF A+ SWI Y+ + R +++A+L+ VRLPLL +L + E LI+++ TCK L E
Sbjct: 197 TVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNE 256
Query: 272 AMKYHLLP----LDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAP--KAIRSVECYDFEED 325
A+KYH +P Q +L+ PR PKV+ VGG++ + SVE Y + D
Sbjct: 257 ALKYHFMPEHRLSHQTVLMTRPR-------CAPKVLCAVGGKSGLFACLDSVEMYFPQND 309
Query: 326 RWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLR--------VRTVDVYDGVKDQWTSI 377
W +A L R G+ + VY +GG ++R +V+ ++ + WTS+
Sbjct: 310 SWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSL 369
Query: 378 ASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVG 437
M E RSTLG VL LYA+GG+DG + L SVE Y K +W VAPM T RS
Sbjct: 370 ERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAA 429
Query: 438 VVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGG 497
V++G +YA+GGY A +++VE+Y+P+ + W VA M+ +R GVGV+ G ++ GG
Sbjct: 430 VLDGMIYAIGGYGPAH---MNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGG 486
Query: 498 HDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYY 557
H+G S+E YDP N W M R G ++ LYVVGG GS L +V+ Y
Sbjct: 487 HNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKY 546
Query: 558 NPVTDKW 564
+P++D W
Sbjct: 547 DPISDTW 553
Score = 96.7 bits (239), Expect = 5e-20
Identities = 49/138 (35%), Positives = 79/138 (57%)
Query: 299 LPKVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGS 358
L ++ +GG P + SVE YD +D W+ +A + +R GV M G ++ VGG NG
Sbjct: 431 LDGMIYAIGGYGPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGV 490
Query: 359 LRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKT 418
+ +++ YD ++QWT M+E R+ +GAAV+++ LY VGG GS+ L +V+ Y +
Sbjct: 491 SHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPIS 550
Query: 419 NEWFFVAPMNTRRSSVGV 436
+ W A M R + G+
Sbjct: 551 DTWLDSAGMIYCRCNFGL 568
Score = 52.0 bits (123), Expect = 2e-06
Identities = 28/96 (29%), Positives = 42/96 (43%)
Query: 297 VSLPKVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFN 356
V L + +V G + S+E YD +++W + R G + ++Y VGG +
Sbjct: 476 VMLGFIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHS 535
Query: 357 GSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVL 392
GS + TV YD + D W A M R G L
Sbjct: 536 GSSYLNTVQKYDPISDTWLDSAGMIYCRCNFGLTAL 571
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 379 bits (973), Expect = e-105
Identities = 210/539 (38%), Positives = 318/539 (58%), Gaps = 11/539 (2%)
Query: 49 LCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYI 108
LCDV + I H++VLA PYF AMF +M+E+K IEI+D DG + L+ ++
Sbjct: 66 LCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFV 125
Query: 109 YTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFADVHTCTDLL 168
Y++ + +T +NVQ LL AA +LQ+ V + CC++++ HP+NCL +RAFA+ H DL+
Sbjct: 126 YSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNRIDLM 185
Query: 169 QQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWINYEKETR 228
A+ YA HF EV+ E+F+S+S + L+SS L + +E++V+ A I W+ +
Sbjct: 186 DMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHH 245
Query: 229 LEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLLPLDQRLLIK- 287
+ + + + VRLPLLP D+L+ V +E ++K N C+D L EA YH L L R +
Sbjct: 246 SKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYH-LHLSSRAVPDF 304
Query: 288 --NPRTKPRTPVSLPKVMIVVGGQAPKA--IRSVECYDFEEDRWDQIAELPSRRCRAGVV 343
+ RT PR + V+ VGG+ RS+ECY ++ W E+ SRR GV+
Sbjct: 305 EYSIRTTPRKHTA--GVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVI 362
Query: 344 FMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFD 403
+ G VYAVGG +G+ + +++++D + ++W ASM +R + A L +YA+GG D
Sbjct: 363 SVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLD 422
Query: 404 GSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQY 463
+T VE Y ++++W VAPMNT R VG + +YAVGG DG + LS+VE+Y
Sbjct: 423 DNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMA--SLSSVERY 480
Query: 464 NPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVEVYDPGTNTWKQVADM 523
+P ++WI V +M RR+G GV L G LY GG D SVE YDP +N W VA +
Sbjct: 481 DPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAAL 540
Query: 524 NMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKWTLLPTNMSTGRSYAGVAV 582
R G+ V G ++ VGG +G+ L +VE ++PV ++W L+ ++S R+ AGVAV
Sbjct: 541 TTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELV-GSVSHCRAGAGVAV 598
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 360 bits (924), Expect = 2e-99
Identities = 193/535 (36%), Positives = 297/535 (55%), Gaps = 11/535 (2%)
Query: 36 AFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKD 95
A ++ NELR + LCDV+I E AH+ +L +CS YF A+FT + ++ K I
Sbjct: 25 ACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPG 84
Query: 96 VDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGI 155
+ + +I+Y YT + +T +NV+ LL AA +M + + CC+FL+S+L NC+GI
Sbjct: 85 ISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGI 144
Query: 156 RAFADVHTCTDLLQQANAYAEQHFPE-VMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVF 214
F D + C +L Q+A + +F E V + EFL LS+ ++ +I D+L V E+ VF
Sbjct: 145 CKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVF 204
Query: 215 EAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMK 274
EA++ WI+++ + R +H++ L+ VRL L+ +Y + V+ +K++ CK +I A+K
Sbjct: 205 EAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALK 264
Query: 275 --YHL-LPLDQRLLIKNPRTKPRTPVSLPKVMIVVGG-QAPKAIRSVECYDFEEDRWDQI 330
Y L + NP T+PR P + ++ +GG ++E YD DRW +
Sbjct: 265 AMYDLNMNGPSNSDFTNPLTRPRLPYA---ILFAIGGWSGGSPTNAIEAYDARADRWVNV 321
Query: 331 -AELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGA 389
E S R G ++ G+VY +GGF+ +V +D VK W +A M RR +
Sbjct: 322 TCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSV 381
Query: 390 AVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGY 449
VL + +YA+GGFDG L + E Y +TN+W +APM+ +RS + GK+Y GG+
Sbjct: 382 TVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGF 441
Query: 450 DGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVEV 509
+G +CL T E YN +N+W +A M +RRSG GV +YA GG DG +S E
Sbjct: 442 NG--NECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEA 499
Query: 510 YDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKW 564
Y P NTW+ + M R N G+ V+ LL+VVGG +G +VE Y+ TD+W
Sbjct: 500 YSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEW 554
Score = 109 bits (272), Expect = 8e-24
Identities = 57/141 (40%), Positives = 83/141 (58%)
Query: 301 KVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLR 360
KV I G + + + E Y+ E ++W IA + SRR GV+ HVYAVGGF+G+ R
Sbjct: 434 KVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANR 493
Query: 361 VRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNE 420
+R+ + Y V + W +I +M RS G V++DLL+ VGGF+G T +VE Y KT+E
Sbjct: 494 LRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDE 553
Query: 421 WFFVAPMNTRRSSVGVGVVEG 441
W+ M+ RS++ VV G
Sbjct: 554 WYDAHDMSIYRSALSCCVVPG 574
Score = 29.6 bits (65), Expect = 8.1
Identities = 12/46 (26%), Positives = 23/46 (50%)
Query: 538 LLYVVGGDDGSCNLASVEYYNPVTDKWTLLPTNMSTGRSYAGVAVI 583
+L+ +GG G ++E Y+ D+W + + R+Y G A +
Sbjct: 292 ILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYL 337
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 351 bits (900), Expect = 1e-96
Identities = 212/560 (37%), Positives = 312/560 (55%), Gaps = 19/560 (3%)
Query: 32 HMGKAFKVMNELRSKQLLCDVMIV-----AEDVEIEAHRVVLAACSPYFCAMFTGDMSES 86
H +AF +MNELR Q LCDV + A + AH+VVLA+ SP F AMFT + E
Sbjct: 59 HTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQ 118
Query: 87 KAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQ 146
+ + I+ + + + +LI++ YTA I + E+ V ++ A + Q+ V + C DFL Q
Sbjct: 119 GMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQ 178
Query: 147 LHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLT 206
L P+N +GI FA+ C +L Q+A Y HF EV EEF +LS Q+ +LIS D L
Sbjct: 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLN 238
Query: 207 VSSEEKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCK 266
V E +VF A I+W+ Y+ E R ++ L+ VR L ++L +++ ++++++ CK
Sbjct: 239 VRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCK 298
Query: 267 DFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECYDFEEDR 326
D+L++ ++ L K + P + +++ GG +++ +E Y+ +
Sbjct: 299 DYLVKI-------FEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGT 351
Query: 327 WDQIAELPSRRCRAGVVFMAGHVYAVGGFN----GSLRVRTVDVYDGVKDQWTSIASMQE 382
W ++A+L R + G +YAVGG N G+ +D Y+ + +QW+ A M
Sbjct: 352 WLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSV 411
Query: 383 RRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGK 442
R+ +G V++ +YAVGG G SVE Y + +EW VAPM TRR VGV V+
Sbjct: 412 PRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRL 471
Query: 443 LYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPL 502
LYAVGG+DG +R L++ E Y P NEW + M+T RSGAGV VL +YA GG+DG
Sbjct: 472 LYAVGGFDGTNR--LNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQD 529
Query: 503 VRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTD 562
SVE YD T TW VA M R G+ G +YV+GG DG L SVE Y+P TD
Sbjct: 530 QLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTD 589
Query: 563 KWTLLPTNMSTGRSYAGVAV 582
W+ + T M++GRS GVAV
Sbjct: 590 TWSEV-TRMTSGRSGVGVAV 608
Score = 132 bits (331), Expect = 1e-30
Identities = 79/195 (40%), Positives = 108/195 (55%), Gaps = 4/195 (2%)
Query: 395 LLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGA-- 452
L+Y GG+ + L+ +EAY+ W +A + RS + VV G LYAVGG + +
Sbjct: 327 LIYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPD 385
Query: 453 SRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVEVYDP 512
S ++ YNP TN+W A MS R+ GVGV+ G +YA GG G + SVE Y+P
Sbjct: 386 GNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEP 445
Query: 513 GTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKWTLLPTNMS 572
+ W VA M R GV +N LLY VGG DG+ L S E Y P ++W ++ T M+
Sbjct: 446 ERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMI-TAMN 504
Query: 573 TGRSYAGVAVIHKSL 587
T RS AGV V+H +
Sbjct: 505 TIRSGAGVCVLHNCI 519
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 351 bits (900), Expect = 1e-96
Identities = 212/560 (37%), Positives = 312/560 (55%), Gaps = 19/560 (3%)
Query: 32 HMGKAFKVMNELRSKQLLCDVMIV-----AEDVEIEAHRVVLAACSPYFCAMFTGDMSES 86
H +AF +MNELR Q LCDV + A + AH+VVLA+ SP F AMFT + E
Sbjct: 59 HTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQ 118
Query: 87 KAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQ 146
+ + I+ + + + +LI++ YTA I + E+ V ++ A + Q+ V + C DFL Q
Sbjct: 119 GMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQ 178
Query: 147 LHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLT 206
L P+N +GI FA+ C +L Q+A Y HF EV EEF +LS Q+ +LIS D L
Sbjct: 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLN 238
Query: 207 VSSEEKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCK 266
V E +VF A I+W+ Y+ E R ++ L+ VR L ++L +++ ++++++ CK
Sbjct: 239 VRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCK 298
Query: 267 DFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECYDFEEDR 326
D+L++ ++ L K + P + +++ GG +++ +E Y+ +
Sbjct: 299 DYLVKI-------FEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGT 351
Query: 327 WDQIAELPSRRCRAGVVFMAGHVYAVGGFN----GSLRVRTVDVYDGVKDQWTSIASMQE 382
W ++A+L R + G +YAVGG N G+ +D Y+ + +QW+ A M
Sbjct: 352 WLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSV 411
Query: 383 RRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGK 442
R+ +G V++ +YAVGG G SVE Y + +EW VAPM TRR VGV V+
Sbjct: 412 PRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRL 471
Query: 443 LYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPL 502
LYAVGG+DG +R L++ E Y P NEW + M+T RSGAGV VL +YA GG+DG
Sbjct: 472 LYAVGGFDGTNR--LNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQD 529
Query: 503 VRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTD 562
SVE YD T TW VA M R G+ G +YV+GG DG L SVE Y+P TD
Sbjct: 530 QLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTD 589
Query: 563 KWTLLPTNMSTGRSYAGVAV 582
W+ + T M++GRS GVAV
Sbjct: 590 TWSEV-TRMTSGRSGVGVAV 608
Score = 132 bits (331), Expect = 1e-30
Identities = 79/195 (40%), Positives = 108/195 (55%), Gaps = 4/195 (2%)
Query: 395 LLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGA-- 452
L+Y GG+ + L+ +EAY+ W +A + RS + VV G LYAVGG + +
Sbjct: 327 LIYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPD 385
Query: 453 SRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVEVYDP 512
S ++ YNP TN+W A MS R+ GVGV+ G +YA GG G + SVE Y+P
Sbjct: 386 GNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEP 445
Query: 513 GTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKWTLLPTNMS 572
+ W VA M R GV +N LLY VGG DG+ L S E Y P ++W ++ T M+
Sbjct: 446 ERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMI-TAMN 504
Query: 573 TGRSYAGVAVIHKSL 587
T RS AGV V+H +
Sbjct: 505 TIRSGAGVCVLHNCI 519
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 320 bits (820), Expect = 2e-87
Identities = 194/561 (34%), Positives = 287/561 (51%), Gaps = 21/561 (3%)
Query: 31 AHMGKAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKK 90
+H ++ NE R +L DV+I E E HR VL+ACS YF AMF D ES+
Sbjct: 47 SHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREML 106
Query: 91 IEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPT 150
+EI + + + + Y+YT ++++T ENVQ L +SL Q+ +R C FL+ QL P
Sbjct: 107 VEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPC 166
Query: 151 NCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSE 210
NCLGI+ FAD H+ L + +A Q F +V EEFL L D++ I SD+L + E
Sbjct: 167 NCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKE 226
Query: 211 EKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLI 270
E VFEAV+ W+ + R + +L+ HVRLPLL +Y VQTVE + LI+N+ C L
Sbjct: 227 EMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLH 286
Query: 271 EAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKA---IRSVECYDFEEDRW 327
EA +YH+L + + +PRT+PR +V++VVGG + ECYD W
Sbjct: 287 EARRYHILGNE----MMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEW 342
Query: 328 DQIAELPS-RRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRST 386
+A+LP + V + + G G + R V +Y+ + W +AS+ + R
Sbjct: 343 KSLAKLPEFTKSEYAVCALRNDILVSG---GRINSRDVWIYNSQLNIWIRVASLNKGRWR 399
Query: 387 LGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAV 446
AVL +Y VGG+DG L+SVE Y +N W VAP+ SS V GKL+ +
Sbjct: 400 HKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVI 459
Query: 447 GGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKS 506
GG C V+ Y+P TN W+ A + + L+ +Y GG + K+
Sbjct: 460 GG-GPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGG-----LTKA 513
Query: 507 VEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGG--DDGSCNLASVEYYNPVTDKW 564
+ YDP + W V + + N G+ NG +Y++GG ++G ++ Y+P T
Sbjct: 514 IYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEAT-DTILCYDPATSII 572
Query: 565 TLLPTNMSTGRSYAGVAVIHK 585
T + M SY G IH+
Sbjct: 573 TGVAA-MPRPVSYHGCVTIHR 592
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 313 bits (802), Expect = 3e-85
Identities = 192/560 (34%), Positives = 288/560 (51%), Gaps = 18/560 (3%)
Query: 40 MNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQ 99
+N++R+ Q CDV + +AHR+VLAA SPYF A+FTG M ES + I ++
Sbjct: 27 INKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVVPILGIEAG 86
Query: 100 TLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFA 159
L+D+IYT + + NVQ L+ AA +LQL +V CC+FL+ Q+ P NC+GI F+
Sbjct: 87 IFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLNCIGIFQFS 146
Query: 160 DVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVIS 219
+ C DLL+ + Y HF EV GEEFL+L+ DQ+ ++ S++L++ E +VF A +
Sbjct: 147 EQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQ 206
Query: 220 WINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLLP 279
WI + R +H+ ++++ +R PLLP L++ +E + + L E + P
Sbjct: 207 WILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKEYCEVCKSP 266
Query: 280 LDQRLLIKNPRTKPRTPVSLPKVMIVVGGQA---------PKAIRSVECYDFEEDRWDQI 330
+ + +K R K + VGG +A+ VE +D W +
Sbjct: 267 KENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTV 326
Query: 331 AELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAA 390
+ L R GV + G VYA+GG S+ + YD V QWT++ASM R LG
Sbjct: 327 SSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVC 386
Query: 391 VLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYD 450
V +YA+GG+ G+ ++E + N+W V M R G ++G +Y +GG
Sbjct: 387 VCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGIS 446
Query: 451 GASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGG-HDGPLVRKSVEV 509
+ L + E Y+P + W + M TRR+ GV L+ +Y+ GG ++ +VE
Sbjct: 447 NEGIE-LRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEK 505
Query: 510 YDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCN------LASVEYYNPVTDK 563
Y W +VA M + R V AVNGLLYV GG S + L SVE YNP +D
Sbjct: 506 YSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDT 565
Query: 564 WTLLPTNMSTGRSYAGVAVI 583
WT + NM T R GVAV+
Sbjct: 566 WTEI-GNMITSRCEGGVAVL 584
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 312 bits (800), Expect = 5e-85
Identities = 185/530 (34%), Positives = 285/530 (53%), Gaps = 11/530 (2%)
Query: 39 VMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDG 98
VMN +R ++ LCDV+++ ++ +I AHRVVLAA S +F MFT +M ESK+ ++E+KD +
Sbjct: 33 VMNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEP 92
Query: 99 QTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAF 158
+ +L+++ YTA I V NVQ LL AA+ Q+ V++ C DFL+ Q+ +NCLGI
Sbjct: 93 DIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVL 152
Query: 159 ADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVI 218
A+ C +L A+ + QHF EV +EFL L + +V L++ D LTV +E++V++A +
Sbjct: 153 AECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAV 212
Query: 219 SWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLL 278
W+ Y++ R M ++ VR PL+ +++L +TV+ E LI++N C +I M+YHLL
Sbjct: 213 RWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLL 272
Query: 279 -PLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRR 337
P D+ L+ T+PR ++ + GG P++ R D+ W I +R
Sbjct: 273 SPEDREELVDG--TRPRRKKHDYRIAL-FGGSQPQSCRYFNPKDYS---WTDIRCPFEKR 326
Query: 338 CRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLY 397
A VF VY +GG + ++ +D Y+ VKD W S R +L A +Y
Sbjct: 327 RDAACVFWDNVVYILGG-SQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIY 385
Query: 398 AVGGFD-GSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDG--ASR 454
GG + G++ L E Y +T W M T+R S G+ G +Y GG G S
Sbjct: 386 TSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSG 445
Query: 455 QCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVEVYDPGT 514
+ L++ E Y+PAT W + M R G+ + +++A GG +G +VE YD
Sbjct: 446 RVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKL 505
Query: 515 NTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKW 564
N WK V+ M AV ++YV+ G G L + YN TDKW
Sbjct: 506 NEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 555
Score = 56.6 bits (135), Expect = 6e-08
Identities = 52/195 (26%), Positives = 80/195 (41%), Gaps = 11/195 (5%)
Query: 397 YAVGGFDGSTGLASVEAYSYKTNEWFFV-APMNTRRSSVGVGVVEGKLYAVGGYDGASRQ 455
Y + F GS S ++ K W + P RR + V + +Y +GG +
Sbjct: 293 YRIALFGGSQP-QSCRYFNPKDYSWTDIRCPFEKRRDAACV-FWDNVVYILGG---SQLF 347
Query: 456 CLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHD-GPLVRKSVEVYDPGT 514
+ ++ YN + W T R G++Y +GG + G E YD T
Sbjct: 348 PIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRT 407
Query: 515 NTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCN----LASVEYYNPVTDKWTLLPTN 570
+W M R + G+ NGL+YV GG G+ L S E Y+P T+ WT L
Sbjct: 408 ESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPM 467
Query: 571 MSTGRSYAGVAVIHK 585
+ +++ V V K
Sbjct: 468 IEARKNHGLVFVKDK 482
Score = 36.2 bits (82), Expect = 0.086
Identities = 18/76 (23%), Positives = 34/76 (44%)
Query: 301 KVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLR 360
K+ V G + +VE YD + + W ++ +P + + VY + GF G R
Sbjct: 482 KIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGR 541
Query: 361 VRTVDVYDGVKDQWTS 376
+ + Y+ D+W +
Sbjct: 542 LGHILEYNTETDKWVA 557
>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
Length = 564
Score = 306 bits (783), Expect = 4e-83
Identities = 182/528 (34%), Positives = 282/528 (53%), Gaps = 11/528 (2%)
Query: 41 NELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQT 100
+ + K+ LCDV+++ ++ +I AHRVVLAA S +F MFT +M ESK+ ++E+KD +
Sbjct: 13 SHINLKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDI 72
Query: 101 LSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFAD 160
+ +L+++ YTA I V NVQ LL AA+ Q+ V++ C DFL+ Q+ +NCLGI A+
Sbjct: 73 IEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAE 132
Query: 161 VHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISW 220
C +L A+ + QHF EV +EFL L + +V L++ D LTV +E++V++A + W
Sbjct: 133 CLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRW 192
Query: 221 INYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLL-P 279
+ Y++ R M ++ VR PL+ +++L +TV+ E LI++N C +I M+YHLL P
Sbjct: 193 LKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSP 252
Query: 280 LDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCR 339
D+ L+ T+PR ++ + GG P++ R D+ W I +R
Sbjct: 253 EDREELVDG--TRPRRKKHDYRIAL-FGGSQPQSCRYFNPKDYS---WTDIRCPFEKRRD 306
Query: 340 AGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAV 399
A VF VY +GG + ++ +D Y+ VKD W S R +L A +Y
Sbjct: 307 AACVFWDNVVYILGG-SQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTS 365
Query: 400 GGFD-GSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDG--ASRQC 456
GG + G++ L E Y +T W M T+R S G+ G +Y GG G S +
Sbjct: 366 GGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRV 425
Query: 457 LSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVEVYDPGTNT 516
L++ E Y+PAT W + M R G+ + +++A GG +G +VE YD N
Sbjct: 426 LNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNE 485
Query: 517 WKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKW 564
WK V+ M AV ++YV+ G G L + YN TDKW
Sbjct: 486 WKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 533
Score = 56.6 bits (135), Expect = 6e-08
Identities = 52/195 (26%), Positives = 80/195 (41%), Gaps = 11/195 (5%)
Query: 397 YAVGGFDGSTGLASVEAYSYKTNEWFFV-APMNTRRSSVGVGVVEGKLYAVGGYDGASRQ 455
Y + F GS S ++ K W + P RR + V + +Y +GG +
Sbjct: 271 YRIALFGGSQP-QSCRYFNPKDYSWTDIRCPFEKRRDAACV-FWDNVVYILGG---SQLF 325
Query: 456 CLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHD-GPLVRKSVEVYDPGT 514
+ ++ YN + W T R G++Y +GG + G E YD T
Sbjct: 326 PIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRT 385
Query: 515 NTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCN----LASVEYYNPVTDKWTLLPTN 570
+W M R + G+ NGL+YV GG G+ L S E Y+P T+ WT L
Sbjct: 386 ESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPM 445
Query: 571 MSTGRSYAGVAVIHK 585
+ +++ V V K
Sbjct: 446 IEARKNHGLVFVKDK 460
Score = 36.2 bits (82), Expect = 0.086
Identities = 18/76 (23%), Positives = 34/76 (44%)
Query: 301 KVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLR 360
K+ V G + +VE YD + + W ++ +P + + VY + GF G R
Sbjct: 460 KIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGR 519
Query: 361 VRTVDVYDGVKDQWTS 376
+ + Y+ D+W +
Sbjct: 520 LGHILEYNTETDKWVA 535
>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 875
Score = 294 bits (753), Expect = 1e-79
Identities = 176/554 (31%), Positives = 281/554 (50%), Gaps = 21/554 (3%)
Query: 29 NPAHMGKAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMF---TGDMSE 85
+P H + K +N+ R + D+ IV E E E H+ VLA+CS YF + D +
Sbjct: 308 DPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQ 367
Query: 86 SKAKKIEI--KDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFL 143
+K+E+ ++ L L++++YT + + N + LL AAS Q + C FL
Sbjct: 368 GGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL 427
Query: 144 QSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSD 203
+ QL +NCLG+ A A+ C++L A A+A Q FPEV EE LS+S D + +S+D
Sbjct: 428 EKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSND 487
Query: 204 KLTVSSEEKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNN 263
L +EE V+E VI WI + TR ++ A+L+ VRLP + YL+ V+ E LIK++
Sbjct: 488 SLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSE 547
Query: 264 TCKDFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQ-----APKAIRSVE 318
C+D + EA +YH+LP R ++ PRT+PR + +V+++VGG+ +++ +V
Sbjct: 548 ACRDLVNEAKRYHMLP-HARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVT 606
Query: 319 CYDFEEDRWDQIAELP-SRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSI 377
C++ + ++W +A LP R VV ++Y GG + + V Y + D W +
Sbjct: 607 CWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLV 666
Query: 378 ASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVG 437
+ M R + V + +Y +GG + + VE Y TN+W VAP+ S
Sbjct: 667 SRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAAT 726
Query: 438 VVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGG 497
V GK+Y GG + A R ++ Y P TN W ++ A L+G ++ GG
Sbjct: 727 VCGGKIYVFGGVNEAGR-AAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGG 785
Query: 498 HDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGG---DDGSCNLASV 554
++ +YDP K +MN R+ ++G +Y GG +G L ++
Sbjct: 786 ----AYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPA-LGNM 840
Query: 555 EYYNPVTDKWTLLP 568
E Y P T+ WTLLP
Sbjct: 841 EAYEPTTNTWTLLP 854
>gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain
containing 9 [Homo sapiens]
Length = 875
Score = 294 bits (753), Expect = 1e-79
Identities = 176/554 (31%), Positives = 281/554 (50%), Gaps = 21/554 (3%)
Query: 29 NPAHMGKAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMF---TGDMSE 85
+P H + K +N+ R + D+ IV E E E H+ VLA+CS YF + D +
Sbjct: 308 DPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQ 367
Query: 86 SKAKKIEI--KDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFL 143
+K+E+ ++ L L++++YT + + N + LL AAS Q + C FL
Sbjct: 368 GGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL 427
Query: 144 QSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSD 203
+ QL +NCLG+ A A+ C++L A A+A Q FPEV EE LS+S D + +S+D
Sbjct: 428 EKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSND 487
Query: 204 KLTVSSEEKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNN 263
L +EE V+E VI WI + TR ++ A+L+ VRLP + YL+ V+ E LIK++
Sbjct: 488 SLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSE 547
Query: 264 TCKDFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQ-----APKAIRSVE 318
C+D + EA +YH+LP R ++ PRT+PR + +V+++VGG+ +++ +V
Sbjct: 548 ACRDLVNEAKRYHMLP-HARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVT 606
Query: 319 CYDFEEDRWDQIAELP-SRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSI 377
C++ + ++W +A LP R VV ++Y GG + + V Y + D W +
Sbjct: 607 CWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLV 666
Query: 378 ASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVG 437
+ M R + V + +Y +GG + + VE Y TN+W VAP+ S
Sbjct: 667 SRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAAT 726
Query: 438 VVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGG 497
V GK+Y GG + A R ++ Y P TN W ++ A L+G ++ GG
Sbjct: 727 VCGGKIYVFGGVNEAGR-AAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGG 785
Query: 498 HDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGG---DDGSCNLASV 554
++ +YDP K +MN R+ ++G +Y GG +G L ++
Sbjct: 786 ----AYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPA-LGNM 840
Query: 555 EYYNPVTDKWTLLP 568
E Y P T+ WTLLP
Sbjct: 841 EAYEPTTNTWTLLP 854
>gi|223890235 intracisternal A particle-promoted polypeptide isoform
2 [Homo sapiens]
Length = 582
Score = 292 bits (747), Expect = 7e-79
Identities = 174/519 (33%), Positives = 266/519 (51%), Gaps = 11/519 (2%)
Query: 40 MNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQ 99
+N++R+ Q CDV + +AHR+VLAA SPYF A+FTG M ES + I ++
Sbjct: 27 INKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVVPILGIEAG 86
Query: 100 TLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFA 159
L+D+IYT + + NVQ L+ AA +LQL +V CC+FL+ Q+ P NC+GI F+
Sbjct: 87 IFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLNCIGIFQFS 146
Query: 160 DVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVIS 219
+ C DLL+ + Y HF EV GEEFL+L+ DQ+ ++ S++L++ E +VF A +
Sbjct: 147 EQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQ 206
Query: 220 WINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLLP 279
WI + R +H+ ++++ +R PLLP L++ +E + + L E + P
Sbjct: 207 WILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKEYCEVCKSP 266
Query: 280 LDQRLLIKNPRTKPRTPVSLPKVMIVVGGQA---------PKAIRSVECYDFEEDRWDQI 330
+ + +K R K + VGG +A+ VE +D W +
Sbjct: 267 KENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTV 326
Query: 331 AELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAA 390
+ L R GV + G VYA+GG S+ + YD V QWT++ASM R LG
Sbjct: 327 SSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVC 386
Query: 391 VLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYD 450
V +YA+GG+ G+ ++E + N+W V M R G ++G +Y +GG
Sbjct: 387 VCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGIS 446
Query: 451 GASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGG-HDGPLVRKSVEV 509
+ L + E Y+P + W + M TRR+ GV L+ +Y+ GG ++ +VE
Sbjct: 447 NEGIE-LRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEK 505
Query: 510 YDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGS 548
Y W +VA M + R V AVNGLLYV GG S
Sbjct: 506 YSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSS 544
Score = 124 bits (311), Expect = 2e-28
Identities = 72/198 (36%), Positives = 107/198 (54%), Gaps = 12/198 (6%)
Query: 396 LYAVGGF--------DGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVG 447
LYAVGG+ S L+ VE + + W V+ ++ RS +GV V+ G +YA+G
Sbjct: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
Query: 448 GYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSV 507
G + E Y+P T +W VA M+ R G GV V G +YA GG G + ++
Sbjct: 350 GEKDS--MIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTI 407
Query: 508 EVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGG-DDGSCNLASVEYYNPVTDKWTL 566
E +DP N W+ V +M + R G C + GL+YV+GG + L S E Y+P++ +W+
Sbjct: 408 ERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSP 467
Query: 567 LPTNMSTGRSYAGVAVIH 584
LP M T R+Y GVA ++
Sbjct: 468 LPP-MGTRRAYLGVAALN 484
Score = 91.7 bits (226), Expect = 2e-18
Identities = 49/157 (31%), Positives = 83/157 (52%), Gaps = 2/157 (1%)
Query: 316 SVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGF-NGSLRVRTVDVYDGVKDQW 374
++E +D +E++W+ + + R G M G +Y +GG N + +R+ +VYD + +W
Sbjct: 406 TIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRW 465
Query: 375 TSIASMQERRSTLGAAVLNDLLYAVGGFDGST-GLASVEAYSYKTNEWFFVAPMNTRRSS 433
+ + M RR+ LG A LND +Y+VGG++ + L +VE YS++ +W VA M R+
Sbjct: 466 SPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAG 525
Query: 434 VGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEW 470
+ V V G LY GG + +Y +W
Sbjct: 526 MCVVAVNGLLYVSGGRSSSHDFLAPDTHRYEVFRLKW 562
Score = 62.8 bits (151), Expect = 9e-10
Identities = 36/119 (30%), Positives = 63/119 (52%), Gaps = 3/119 (2%)
Query: 302 VMIVVGGQAPKAI--RSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSL 359
++ V+GG + + I RS E YD RW + + +RR GV + +Y+VGG+N +
Sbjct: 438 LIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQ 497
Query: 360 -RVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYK 417
+ TV+ Y +++W +ASM+ R+ + +N LLY GG S + + + Y+
Sbjct: 498 DALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPDTHRYE 556
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 268 bits (684), Expect = 1e-71
Identities = 180/576 (31%), Positives = 288/576 (50%), Gaps = 68/576 (11%)
Query: 26 ITVNPAHMGKAFKVMNELRSKQLLCDVMIVAEDVE--IEAHRVVLAACSPYFCAMFTGDM 83
I + H + ++LR + LLCDV ++ D + HRV++A+ S YF AMFTG M
Sbjct: 68 IFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGM 127
Query: 84 SESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFL 143
E I++ V L K+ID+IYTA++ + +N+Q L AAS LQ++ V C FL
Sbjct: 128 KEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFL 187
Query: 144 QSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSD 203
S + NC+ + A+ + T++ + N++ ++FP ++ EFL L +++ ++SS+
Sbjct: 188 ISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSN 247
Query: 204 KLTVSSEEKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNN 263
L +E ++F+A W+ E E R++ AKLM+++R PL+ L+ V+ ++ +N
Sbjct: 248 SLKHCTELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDN 306
Query: 264 TCKDFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECYDFE 323
TC + L+EA Y ++P Q ++ ++ RT R+ +
Sbjct: 307 TCVNLLLEASNYQMMPYMQPVM-QSDRTAIRSDTT------------------------- 340
Query: 324 EDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRV--RTVDVYDGVKDQWTSIASMQ 381
H+ +GG V + + +YD +W S+A M
Sbjct: 341 ------------------------HLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMD 376
Query: 382 ERRSTLGAAVLNDLLYAVGG---FD--GSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGV 436
R G AV+ + LY VGG +D G T + +V + + N+W VA +N +R+ +
Sbjct: 377 APRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHL 436
Query: 437 GVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATG 496
++G LYAVGG + A L TVE YNP TNEW YVA MS G V G +Y +G
Sbjct: 437 SALKGYLYAVGGRNAAGE--LPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISG 494
Query: 497 GHDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDD--GSCN---L 551
G +K + +DP T+ W Q A M R +C V LYV+GG+ G+ + +
Sbjct: 495 GITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDV 554
Query: 552 ASVEYYNPVTDKWTLLPTNMSTGRSYAGVAVIHKSL 587
S EYY+P+ D+WT + M G+S GVAV +
Sbjct: 555 LSCEYYSPILDQWTPIAA-MLRGQSDVGVAVFENKI 589
Score = 40.0 bits (92), Expect = 0.006
Identities = 24/81 (29%), Positives = 34/81 (41%), Gaps = 2/81 (2%)
Query: 314 IRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGF--NGSLRVRTVDVYDGVK 371
+ S E Y D+W IA + + GV +Y VGG+ N V V YD K
Sbjct: 554 VLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDK 613
Query: 372 DQWTSIASMQERRSTLGAAVL 392
D+W + + E + A L
Sbjct: 614 DEWHKVFDLPESLGGIRACTL 634
>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
Length = 589
Score = 267 bits (682), Expect = 2e-71
Identities = 176/541 (32%), Positives = 259/541 (47%), Gaps = 17/541 (3%)
Query: 40 MNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKD-VDG 98
+N LR + DV + A D HR VLAA S YF AMF+ + ES+ + +D +
Sbjct: 36 LNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHP 95
Query: 99 QTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAF 158
+ L L+D+ Y++ I + EEN + LL A +LQ DVR +FL+ L P+NCLG+
Sbjct: 96 EVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLFPSNCLGMMLL 155
Query: 159 ADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVI 218
+D H C L + + HF V E+F SLS D + LISSD+L E VFEA++
Sbjct: 156 SDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDELETEDERVVFEAIL 215
Query: 219 SWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLL 278
W+ ++ E R H+ +L+ VRL LLP D L + V EAL+ + K + EA++
Sbjct: 216 QWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMADERTKLIMDEALRCKTR 275
Query: 279 PLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRC 338
L ++ +P +PR ++++GGQ + + D + A+LPS R
Sbjct: 276 ILQNDGVVTSPCARPR---KAGHTLLILGGQTFMCDKIYQ-VDHKAKEIIPKADLPSPRK 331
Query: 339 RAGVVFMAGHVYAVGGFNGSLRV-RTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLY 397
+ VY GG V + V VYD V ++W+ A M R G+A L + LY
Sbjct: 332 EFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLY 391
Query: 398 AVGGFDG---------STGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGG 448
VGG S L VE Y N+W VAP+ S+ V + KL+ GG
Sbjct: 392 VVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVFGG 451
Query: 449 YDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVE 508
R +S V+ Y+P+ N W A+ VL Q++ GG D S
Sbjct: 452 -TSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGG-DTEFTAASAY 509
Query: 509 VYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKWTLLP 568
+D TN W ++ DM R + A LYVVGG G+ +++ Y+P +D W +
Sbjct: 510 RFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNCIT 569
Query: 569 T 569
T
Sbjct: 570 T 570
Score = 51.2 bits (121), Expect = 3e-06
Identities = 27/105 (25%), Positives = 48/105 (45%), Gaps = 3/105 (2%)
Query: 279 PLDQRLLIKNPRTKP---RTPVSLPKVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPS 335
P + R IK +P L + ++GG S +D E ++W +I ++ +
Sbjct: 467 PSENRWTIKAECPQPWRYTAAAVLGSQIFIMGGDTEFTAASAYRFDCETNQWTRIGDMTA 526
Query: 336 RRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASM 380
+R + +Y VGG+ G+ R +T+D YD D W I ++
Sbjct: 527 KRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNCITTV 571
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 261 bits (667), Expect = 1e-69
Identities = 189/612 (30%), Positives = 292/612 (47%), Gaps = 45/612 (7%)
Query: 3 GESVKLSSQTLIQAGDDEKNQRTITVNPAHMGKAFKV------------MNELRSKQLLC 50
G+ V+ S + + DE +Q+T + G+ K + LR + L
Sbjct: 13 GDVVEKSLEGPLAPSTDEPSQKTGDLVEILNGEKVKFDDAGLSLILQNGLETLRMENALT 72
Query: 51 DVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYT 110
DV++ + E HRVVLAA S YF AMF D+ E K+I IK VD +T+ L+DY YT
Sbjct: 73 DVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAETMHTLLDYTYT 132
Query: 111 AEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFADVHTCTDLLQQ 170
++ +T++NVQ +L AA+L Q + + C FL L+P NC+GI AD H+ L +Q
Sbjct: 133 SKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLADTHSLDSLKKQ 192
Query: 171 ANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWINYEKETRLE 230
+Y Q+F +++ EEFL L +D + ++ SD L V+ E +VFE V+SW+ ++ RL
Sbjct: 193 VQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMSWVRHKPSERLC 252
Query: 231 HMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLLPLDQRLLIKNPR 290
+ ++E+VRLPLL Y V+TVE + LI+ L EA YHL + I + R
Sbjct: 253 LLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLSGNE----IISER 308
Query: 291 TKPRTPVSLPKVMIVVGG--QAPKAIRSVECYDFEEDRWDQIAELP----------SRRC 338
TKPR +V +++GG + + + V C D ++A+LP +
Sbjct: 309 TKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTEHELESENKKWV 368
Query: 339 RAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYA 398
V + VY GG V Y+ ++W I + R VL +Y
Sbjct: 369 EFACVTLKNEVYISGGKETQ---HDVWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVYV 425
Query: 399 VGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLS 458
+GGFDG + +VE Y N W AP+ SS + KLY +GG +
Sbjct: 426 IGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPN-GKLATD 484
Query: 459 TVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVEVYDPGTNTWK 518
+ Y+P+TN+W A M ++Y GG +++ Y P ++W
Sbjct: 485 KTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGG-----AMRALYAYSPLEDSWC 539
Query: 519 QVADMNMCRRNAGVCAVNGLLYVVGG-DDGSCNLASVEYYNPVTDKWT---LLPTNMSTG 574
V ++ R + G+ N LY+ GG D+ + +A+V ++P K T +LP G
Sbjct: 540 LVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPEAQKLTEECVLP----RG 595
Query: 575 RSYAGVAVIHKS 586
S+ G I KS
Sbjct: 596 VSHHGSVTIRKS 607
>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
sapiens]
Length = 589
Score = 261 bits (666), Expect = 2e-69
Identities = 172/543 (31%), Positives = 264/543 (48%), Gaps = 21/543 (3%)
Query: 40 MNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKD-VDG 98
+N LR ++L DV++ A + HR VLAACS YF AMF+G + ES+ ++ + +
Sbjct: 36 LNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHP 95
Query: 99 QTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAF 158
+ L L+DY Y++ + + EEN + LL A +L+ D+R C +FL+ LHPTNCLG+
Sbjct: 96 EVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLL 155
Query: 159 ADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVI 218
+D H CT L + + +F + E+FL L D V L+SS++L E V+E+ I
Sbjct: 156 SDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLVYESAI 215
Query: 219 SWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLL 278
+WI+Y+ + R ++ +L++ VRL LLP YL++ V E LI K+ + EA++ L
Sbjct: 216 NWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVEEAIRCKLK 275
Query: 279 PLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECYDFEEDRWDQI--AELPSR 336
L ++ + +PR + ++GGQ + Y ++ + I A++PS
Sbjct: 276 ILQNDGVVTSLCARPR---KTGHALFLLGGQ---TFMCDKLYLVDQKAKEIIPKADIPSP 329
Query: 337 RCRAGVVFMAGHVYAVGGFNGSLRV-RTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDL 395
R + VY GG V + V VYD + ++W+ A M R G+A L
Sbjct: 330 RKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHC 389
Query: 396 LYAVGGFDGSTG---------LASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAV 446
LY VGG +TG L VE Y N+W VAP+ S+ V + KL+A
Sbjct: 390 LYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAF 449
Query: 447 GGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKS 506
GG S L V+ Y+ N W A VL Q++ GG D S
Sbjct: 450 GG-TSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGG-DTEFSACS 507
Query: 507 VEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKWTL 566
++ T W +V D+ R + A LYVVGG G +++ Y+P D W
Sbjct: 508 AYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWNS 567
Query: 567 LPT 569
+ T
Sbjct: 568 ITT 570
Score = 47.0 bits (110), Expect = 5e-05
Identities = 21/78 (26%), Positives = 40/78 (51%)
Query: 303 MIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVR 362
+ ++GG + S ++ E +W ++ ++ ++R V +Y VGG+ G R +
Sbjct: 494 IFIMGGDTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCK 553
Query: 363 TVDVYDGVKDQWTSIASM 380
T+D YD D W SI ++
Sbjct: 554 TLDCYDPTLDVWNSITTV 571
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,059,598
Number of Sequences: 37866
Number of extensions: 902280
Number of successful extensions: 3473
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 174
Number of HSP's successfully gapped in prelim test: 18
Number of HSP's that attempted gapping in prelim test: 1963
Number of HSP's gapped (non-prelim): 408
length of query: 587
length of database: 18,247,518
effective HSP length: 108
effective length of query: 479
effective length of database: 14,157,990
effective search space: 6781677210
effective search space used: 6781677210
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.