BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|164519140 endothelin converting enzyme 1 isoform 2 [Homo sapiens] (767 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|164519140 endothelin converting enzyme 1 isoform 2 [Homo sapi... 1575 0.0 gi|4503443 endothelin converting enzyme 1 isoform 1 [Homo sapiens] 1553 0.0 gi|164519138 endothelin converting enzyme 1 isoform 4 [Homo sapi... 1550 0.0 gi|164519136 endothelin converting enzyme 1 isoform 3 [Homo sapi... 1498 0.0 gi|153945836 endothelin converting enzyme 2 isoform E [Homo sapi... 1006 0.0 gi|153945771 endothelin converting enzyme 2 isoform D [Homo sapi... 991 0.0 gi|82617560 endothelin converting enzyme 2 isoform B [Homo sapiens] 984 0.0 gi|153945761 endothelin converting enzyme 2 isoform A [Homo sapi... 984 0.0 gi|239049391 membrane metallo-endopeptidase-like 1 [Homo sapiens] 567 e-161 gi|116256333 membrane metallo-endopeptidase [Homo sapiens] 541 e-153 gi|116256331 membrane metallo-endopeptidase [Homo sapiens] 541 e-153 gi|116256327 membrane metallo-endopeptidase [Homo sapiens] 541 e-153 gi|116256329 membrane metallo-endopeptidase [Homo sapiens] 541 e-153 gi|157426891 endothelin converting enzyme-like 1 [Homo sapiens] 532 e-151 gi|90403592 phosphate-regulating neutral endopeptidase [Homo sap... 472 e-133 gi|4557691 Kell blood group, metallo-endopeptidase [Homo sapiens] 351 1e-96 gi|109826564 neurofibromin isoform 1 [Homo sapiens] 32 2.2 gi|4557793 neurofibromin isoform 2 [Homo sapiens] 32 2.2 gi|134152674 rabaptin, RAB GTPase binding effector protein 1 iso... 32 2.9 gi|31377798 rabaptin, RAB GTPase binding effector protein 1 isof... 32 2.9 gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 31 4.9 gi|154744870 zinc finger protein 574 [Homo sapiens] 30 6.5 gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 30 8.4 gi|50345831 forkhead box J3 [Homo sapiens] 30 8.4 >gi|164519140 endothelin converting enzyme 1 isoform 2 [Homo sapiens] Length = 767 Score = 1575 bits (4077), Expect = 0.0 Identities = 767/767 (100%), Positives = 767/767 (100%) Query: 1 MEALRESVLHLALQMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAART 60 MEALRESVLHLALQMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAART Sbjct: 1 MEALRESVLHLALQMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAART 60 Query: 61 QVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCH 120 QVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCH Sbjct: 61 QVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCH 120 Query: 121 DFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYR 180 DFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYR Sbjct: 121 DFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYR 180 Query: 181 ACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSA 240 ACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSA Sbjct: 181 ACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSA 240 Query: 241 DSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQ 300 DSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQ Sbjct: 241 DSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQ 300 Query: 301 MQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINE 360 MQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINE Sbjct: 301 MQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINE 360 Query: 361 SEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYG 420 SEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYG Sbjct: 361 SEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYG 420 Query: 421 TKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLK 480 TKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLK Sbjct: 421 TKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLK 480 Query: 481 WMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWR 540 WMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWR Sbjct: 481 WMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWR 540 Query: 541 VTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGV 600 VTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGV Sbjct: 541 VTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGV 600 Query: 601 VVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRH 660 VVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRH Sbjct: 601 VVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRH 660 Query: 661 TLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESS 720 TLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESS Sbjct: 661 TLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESS 720 Query: 721 HEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 767 HEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW Sbjct: 721 HEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 767 >gi|4503443 endothelin converting enzyme 1 isoform 1 [Homo sapiens] Length = 770 Score = 1553 bits (4021), Expect = 0.0 Identities = 757/761 (99%), Positives = 757/761 (99%) Query: 7 SVLHLALQMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRL 66 S L AL MSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRL Sbjct: 10 SALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRL 69 Query: 67 VVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYA 126 VVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYA Sbjct: 70 VVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYA 129 Query: 127 CGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNET 186 CGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNET Sbjct: 130 CGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNET 189 Query: 187 RIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSN 246 RIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSN Sbjct: 190 RIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSN 249 Query: 247 SNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILD 306 SNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILD Sbjct: 250 SNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILD 309 Query: 307 FETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVV 366 FETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVV Sbjct: 310 FETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVV 369 Query: 367 YDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCL 426 YDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCL Sbjct: 370 YDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCL 429 Query: 427 PRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEET 486 PRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEET Sbjct: 430 PRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEET 489 Query: 487 RKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQL 546 RKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQL Sbjct: 490 RKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQL 549 Query: 547 RKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHEL 606 RKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHEL Sbjct: 550 RKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHEL 609 Query: 607 THAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENI 666 THAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENI Sbjct: 610 THAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENI 669 Query: 667 ADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLIT 726 ADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLIT Sbjct: 670 ADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLIT 729 Query: 727 DPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 767 DPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW Sbjct: 730 DPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 770 >gi|164519138 endothelin converting enzyme 1 isoform 4 [Homo sapiens] Length = 754 Score = 1550 bits (4012), Expect = 0.0 Identities = 753/753 (100%), Positives = 753/753 (100%) Query: 15 MSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLA 74 MSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLA Sbjct: 2 MSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLA 61 Query: 75 AGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKAN 134 AGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKAN Sbjct: 62 AGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKAN 121 Query: 135 PVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRAK 194 PVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRAK Sbjct: 122 PVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRAK 181 Query: 195 PLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQ 254 PLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQ Sbjct: 182 PLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQ 241 Query: 255 SGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANI 314 SGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANI Sbjct: 242 SGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANI 301 Query: 315 TIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQ 374 TIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQ Sbjct: 302 TIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQ 361 Query: 375 ISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVS 434 ISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVS Sbjct: 362 ISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVS 421 Query: 435 DTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKA 494 DTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKA Sbjct: 422 DTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKA 481 Query: 495 DAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQ 554 DAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQ Sbjct: 482 DAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQ 541 Query: 555 WSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQG 614 WSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQG Sbjct: 542 WSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQG 601 Query: 615 REYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKA 674 REYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKA Sbjct: 602 REYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKA 661 Query: 675 AYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRF 734 AYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRF Sbjct: 662 AYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRF 721 Query: 735 RVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 767 RVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW Sbjct: 722 RVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 754 >gi|164519136 endothelin converting enzyme 1 isoform 3 [Homo sapiens] Length = 758 Score = 1498 bits (3878), Expect = 0.0 Identities = 727/729 (99%), Positives = 727/729 (99%) Query: 39 PNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLS 98 P LQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLS Sbjct: 30 PPSLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLS 89 Query: 99 EACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIK 158 EACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIK Sbjct: 90 EACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIK 149 Query: 159 HLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQ 218 HLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQ Sbjct: 150 HLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQ 209 Query: 219 DTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGY 278 DTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGY Sbjct: 210 DTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGY 269 Query: 279 LNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQT 338 LNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQT Sbjct: 270 LNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQT 329 Query: 339 LAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRK 398 LAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRK Sbjct: 330 LAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRK 389 Query: 399 TSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSK 458 TSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSK Sbjct: 390 TSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSK 449 Query: 459 SIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFN 518 SIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFN Sbjct: 450 SIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFN 509 Query: 519 DYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAG 578 DYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAG Sbjct: 510 DYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAG 569 Query: 579 ILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQ 638 ILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQ Sbjct: 570 ILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQ 629 Query: 639 TECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLT 698 TECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLT Sbjct: 630 TECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLT 689 Query: 699 NNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPM 758 NNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPM Sbjct: 690 NNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPM 749 Query: 759 NPPHKCEVW 767 NPPHKCEVW Sbjct: 750 NPPHKCEVW 758 >gi|153945836 endothelin converting enzyme 2 isoform E [Homo sapiens] Length = 765 Score = 1006 bits (2602), Expect = 0.0 Identities = 477/755 (63%), Positives = 601/755 (79%), Gaps = 5/755 (0%) Query: 15 MSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLA 74 M YKRATL +ED ++ EG A P+ ++V F + ++ +RTQ+E L +LLA Sbjct: 14 MVEYKRATLRDEDAPETPVEGGASPDAMEVGFQ--KGTRQLLGSRTQLELVLAGASLLLA 71 Query: 75 AGLVACLAALGIQY-QTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKA 133 A L+ CL ALG+QY + S S CL+EAC+ V IL S+D V PC DF+ ++CGGWI+ Sbjct: 72 ALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGVSPCEDFYQFSCGGWIRR 131 Query: 134 NPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTA-SVSEAERKAQVYYRACMNETRIEELR 192 NP+PDG SRW TF++LW+ NQAI+KHLLEN+T S SEAE+K Q +Y +C+ RIEEL Sbjct: 132 NPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQRFYLSCLQVERIEELG 191 Query: 193 AKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQV 252 A+PL +LIE++GGWNITGPW +DNF + L+ V YR +PFF+VY+SADSK+SNSNVIQV Sbjct: 192 AQPLRDLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFTVYISADSKSSNSNVIQV 251 Query: 253 DQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALA 312 DQSGL LPSRDYYLN+T NEKVLT YL+YM +LG LLGG R QMQQ+L+ E LA Sbjct: 252 DQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTST-REQMQQVLELEIQLA 310 Query: 313 NITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYL 372 NIT+PQ++RRDEE IYHK++ +ELQ LAP+++WL FL+ + P+E+++SEP+VVY +YL Sbjct: 311 NITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSPLELSDSEPVVVYGMDYL 370 Query: 373 EQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFC 432 +Q+S LIN T+ +LNNY+IWNLV+KT+S LD+RF+ A EK +E +YGTKK+C+PRW+ C Sbjct: 371 QQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTC 430 Query: 433 VSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKE 492 +S+T++ LGFALG +FVKATF SK IA +I EI+ AFEE+L L WMDE+TR++AKE Sbjct: 431 ISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKE 490 Query: 493 KADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNR 552 KADAIY+MIG+P+FI++PKELD V++ Y D +F+N + +NFS +V ADQLRK P+R Sbjct: 491 KADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSR 550 Query: 553 DQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDD 612 DQWSMTP VNAYY PTKNEIVFPAGILQAPFY R+ PKALNFGGIGVV+GHELTHAFDD Sbjct: 551 DQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDD 610 Query: 613 QGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGL 672 QGREYDK+GNLRPWW+N S+ AF+ T CM EQY+ Y VNGE +NGR TLGENIADNGGL Sbjct: 611 QGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIADNGGL 670 Query: 673 KAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPS 732 KAAY AY+ W++K+G E LP +GLTN+QLFF+GFAQVWCSVRTPESSHEGL+TDPHSP+ Sbjct: 671 KAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPA 730 Query: 733 RFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 767 RFRV+G+LSNS++F HF CP GSPMNP CEVW Sbjct: 731 RFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 765 >gi|153945771 endothelin converting enzyme 2 isoform D [Homo sapiens] Length = 811 Score = 991 bits (2561), Expect = 0.0 Identities = 480/799 (60%), Positives = 602/799 (75%), Gaps = 47/799 (5%) Query: 15 MSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHS---------------PRSGQRCW--- 56 M YKRATL +ED ++ EG A P+ ++V + PRS W Sbjct: 14 MVEYKRATLRDEDAPETPVEGGASPDAMEVGKGASPFSPGPSPGMTPGTPRSSGLFWRVT 73 Query: 57 --------------------------AARTQVEKRLVVLVVLLAAGLVACLAALGIQY-Q 89 +RTQ+E L +LLAA L+ CL ALG+QY + Sbjct: 74 CPHLRSISGLCSRTMVGFQKGTRQLLGSRTQLELVLAGASLLLAALLLGCLVALGVQYHR 133 Query: 90 TRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNL 149 S S CL+EAC+ V IL S+D V PC DF+ ++CGGWI+ NP+PDG SRW TF++L Sbjct: 134 DPSHSTCLTEACIRVAGKILESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSL 193 Query: 150 WEHNQAIIKHLLENSTA-SVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNI 208 W+ NQAI+KHLLEN+T S SEAE+K Q +Y +C+ RIEEL A+PL +LIE++GGWNI Sbjct: 194 WDQNQAILKHLLENTTFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLRDLIEKIGGWNI 253 Query: 209 TGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNK 268 TGPW +DNF + L+ V YR +PFF+VY+SADSK+SNSNVIQVDQSGL LPSRDYYLN+ Sbjct: 254 TGPWDQDNFMEVLKAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNR 313 Query: 269 TENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIY 328 T NEKVLT YL+YM +LG LLGG R QMQQ+L+ E LANIT+PQ++RRDEE IY Sbjct: 314 TANEKVLTAYLDYMEELGMLLGGRPTST-REQMQQVLELEIQLANITVPQDQRRDEEKIY 372 Query: 329 HKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLN 388 HK++ +ELQ LAP+++WL FL+ + P+E+++SEP+VVY +YL+Q+S LIN T+ +LN Sbjct: 373 HKMSISELQALAPSMDWLEFLSFLLSPLELSDSEPVVVYGMDYLQQVSELINRTEPSILN 432 Query: 389 NYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMF 448 NY+IWNLV+KT+S LD+RF+ A EK +E +YGTKK+C+PRW+ C+S+T++ LGFALG +F Sbjct: 433 NYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLF 492 Query: 449 VKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIM 508 VKATF SK IA +I EI+ AFEE+L L WMDE+TR++AKEKADAIY+MIG+P+FI+ Sbjct: 493 VKATFDRQSKEIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFIL 552 Query: 509 DPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSP 568 +PKELD V++ Y D +F+N + +NFS +V ADQLRK P+RDQWSMTP VNAYY P Sbjct: 553 EPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLP 612 Query: 569 TKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWK 628 TKNEIVFPAGILQAPFY R+ PKALNFGGIGVV+GHELTHAFDDQGREYDK+GNLRPWW+ Sbjct: 613 TKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQ 672 Query: 629 NSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGA 688 N S+ AF+ T CM EQY+ Y VNGE +NGR TLGENIADNGGLKAAY AY+ W++K+G Sbjct: 673 NESLAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGE 732 Query: 689 EHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSE 748 E LP +GLTN+QLFF+GFAQVWCSVRTPESSHEGL+TDPHSP+RFRV+G+LSNS++F Sbjct: 733 EQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLR 792 Query: 749 HFRCPPGSPMNPPHKCEVW 767 HF CP GSPMNP CEVW Sbjct: 793 HFGCPVGSPMNPGQLCEVW 811 >gi|82617560 endothelin converting enzyme 2 isoform B [Homo sapiens] Length = 736 Score = 984 bits (2544), Expect = 0.0 Identities = 462/712 (64%), Positives = 577/712 (81%), Gaps = 3/712 (0%) Query: 58 ARTQVEKRLVVLVVLLAAGLVACLAALGIQY-QTRSPSVCLSEACVSVTSSILSSMDPTV 116 +RTQ+E L +LLAA L+ CL ALG+QY + S S CL+EAC+ V IL S+D V Sbjct: 26 SRTQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGV 85 Query: 117 DPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTA-SVSEAERKA 175 PC DF+ ++CGGWI+ NP+PDG SRW TF++LW+ NQAI+KHLLEN+T S SEAE+K Sbjct: 86 SPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKT 145 Query: 176 QVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFS 235 Q +Y +C+ RIEEL A+PL +LIE++GGWNITGPW +DNF + L+ V YR +PFF+ Sbjct: 146 QRFYLSCLQVERIEELGAQPLRDLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFT 205 Query: 236 VYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEE 295 VY+SADSK+SNSNVIQVDQSGL LPSRDYYLN+T NEKVLT YL+YM +LG LLGG Sbjct: 206 VYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTS 265 Query: 296 AIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYP 355 R QMQQ+L+ E LANIT+PQ++RRDEE IYHK++ +ELQ LAP+++WL FL+ + P Sbjct: 266 T-REQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSP 324 Query: 356 VEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFM 415 +E+++SEP+VVY +YL+Q+S LIN T+ +LNNY+IWNLV+KT+S LD+RF+ A EK + Sbjct: 325 LELSDSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLL 384 Query: 416 EVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEES 475 E +YGTKK+C+PRW+ C+S+T++ LGFALG +FVKATF SK IA +I EI+ AFEE+ Sbjct: 385 ETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEA 444 Query: 476 LSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFF 535 L L WMDE+TR++AKEKADAIY+MIG+P+FI++PKELD V++ Y D +F+N + + Sbjct: 445 LGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLY 504 Query: 536 NFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNF 595 NFS +V ADQLRK P+RDQWSMTP VNAYY PTKNEIVFPAGILQAPFY R+ PKALNF Sbjct: 505 NFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNF 564 Query: 596 GGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEP 655 GGIGVV+GHELTHAFDDQGREYDK+GNLRPWW+N S+ AF+ T CM EQY+ Y VNGE Sbjct: 565 GGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGER 624 Query: 656 VNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVR 715 +NGR TLGENIADNGGLKAAY AY+ W++K+G E LP +GLTN+QLFF+GFAQVWCSVR Sbjct: 625 LNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVR 684 Query: 716 TPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 767 TPESSHEGL+TDPHSP+RFRV+G+LSNS++F HF CP GSPMNP CEVW Sbjct: 685 TPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 736 >gi|153945761 endothelin converting enzyme 2 isoform A [Homo sapiens] Length = 883 Score = 984 bits (2544), Expect = 0.0 Identities = 462/712 (64%), Positives = 577/712 (81%), Gaps = 3/712 (0%) Query: 58 ARTQVEKRLVVLVVLLAAGLVACLAALGIQY-QTRSPSVCLSEACVSVTSSILSSMDPTV 116 +RTQ+E L +LLAA L+ CL ALG+QY + S S CL+EAC+ V IL S+D V Sbjct: 173 SRTQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGV 232 Query: 117 DPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTA-SVSEAERKA 175 PC DF+ ++CGGWI+ NP+PDG SRW TF++LW+ NQAI+KHLLEN+T S SEAE+K Sbjct: 233 SPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKT 292 Query: 176 QVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFS 235 Q +Y +C+ RIEEL A+PL +LIE++GGWNITGPW +DNF + L+ V YR +PFF+ Sbjct: 293 QRFYLSCLQVERIEELGAQPLRDLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFT 352 Query: 236 VYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEE 295 VY+SADSK+SNSNVIQVDQSGL LPSRDYYLN+T NEKVLT YL+YM +LG LLGG Sbjct: 353 VYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTS 412 Query: 296 AIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYP 355 R QMQQ+L+ E LANIT+PQ++RRDEE IYHK++ +ELQ LAP+++WL FL+ + P Sbjct: 413 T-REQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSP 471 Query: 356 VEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFM 415 +E+++SEP+VVY +YL+Q+S LIN T+ +LNNY+IWNLV+KT+S LD+RF+ A EK + Sbjct: 472 LELSDSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLL 531 Query: 416 EVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEES 475 E +YGTKK+C+PRW+ C+S+T++ LGFALG +FVKATF SK IA +I EI+ AFEE+ Sbjct: 532 ETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEA 591 Query: 476 LSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFF 535 L L WMDE+TR++AKEKADAIY+MIG+P+FI++PKELD V++ Y D +F+N + + Sbjct: 592 LGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLY 651 Query: 536 NFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNF 595 NFS +V ADQLRK P+RDQWSMTP VNAYY PTKNEIVFPAGILQAPFY R+ PKALNF Sbjct: 652 NFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNF 711 Query: 596 GGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEP 655 GGIGVV+GHELTHAFDDQGREYDK+GNLRPWW+N S+ AF+ T CM EQY+ Y VNGE Sbjct: 712 GGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGER 771 Query: 656 VNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVR 715 +NGR TLGENIADNGGLKAAY AY+ W++K+G E LP +GLTN+QLFF+GFAQVWCSVR Sbjct: 772 LNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVR 831 Query: 716 TPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 767 TPESSHEGL+TDPHSP+RFRV+G+LSNS++F HF CP GSPMNP CEVW Sbjct: 832 TPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 883 >gi|239049391 membrane metallo-endopeptidase-like 1 [Homo sapiens] Length = 779 Score = 567 bits (1461), Expect = e-161 Identities = 281/707 (39%), Positives = 433/707 (61%), Gaps = 29/707 (4%) Query: 85 GIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWG 144 GI VC + CV + IL +MDPT +PC DF+ +ACGGW++ + +P+ +SR+ Sbjct: 78 GIPEAQEVSEVCTTPGCVIAAARILQNMDPTTEPCDDFYQFACGGWLRRHVIPETNSRYS 137 Query: 145 TFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLG 204 F L + + I+K +LENSTA A KA+ YR+CMN++ IE+ ++PL++++E +G Sbjct: 138 IFDVLRDELEVILKAVLENSTAKDRPAVEKARTLYRSCMNQSVIEKRGSQPLLDILEVVG 197 Query: 205 GWNITGPWAKDNFQDT----------LQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQ 254 GW P A D + +T L ++ + + +++ D +NS+ ++I +DQ Sbjct: 198 GW----PVAMDRWNETVGLEWELERQLALMNSQFNRRVLIDLFIWNDDQNSSRHIIYIDQ 253 Query: 255 SGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGG-----DEEAIRPQMQQILDFET 309 LG+PSR+YY N N KV YL +MV + LL D ++ M Q+L+ ET Sbjct: 254 PTLGMPSREYYFNGGSNRKVREAYLQFMVSVATLLREDANLPRDSCLVQEDMVQVLELET 313 Query: 310 ALANITIPQEKRRDEELIYHKVTAAELQTL--APAINWLPFLNTIFYPVEIN--ESEPIV 365 LA T+PQE+R D +YH++ ELQ+ NW F+ T+ V+I E +V Sbjct: 314 QLAKATVPQEERHDVIALYHRMGLEELQSQFGLKGFNWTLFIQTVLSSVKIKLLPDEEVV 373 Query: 366 VYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTC 425 VY YL+ + +I+T + NY++W LV L QRF+D + + ++GT Sbjct: 374 VYGIPYLQNLENIIDTYSARTIQNYLVWRLVLDRIGSLSQRFKDTRVNYRKALFGTMVEE 433 Query: 426 LPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEE 485 + RW+ CV +N+ A+G ++V+ F DSKS+ E+I +++ F E+L L WMDEE Sbjct: 434 V-RWRECVGYVNSNMENAVGSLYVREAFPGDSKSMVRELIDKVRTVFVETLDELGWMDEE 492 Query: 486 TRKSAKEKADAIYNMIGYPNFIMDP--KELDKVFNDYTAVPDLYFENAMRFFNFSWRVTA 543 ++K A+EKA +I IG+P++I++ + LD+ +++ DLYFEN+++ + + Sbjct: 493 SKKKAQEKAMSIREQIGHPDYILEEMNRRLDEEYSNLNFSEDLYFENSLQNLKVGAQRSL 552 Query: 544 DQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVG 603 +LR+ + + W + +VNA+YSP +N+IVFPAGILQ PF+++ P+ALNFGGIG+V+G Sbjct: 553 RKLREKVDPNLWIIGAAVVNAFYSPNRNQIVFPAGILQPPFFSKEQPQALNFGGIGMVIG 612 Query: 604 HELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYS---VNGEPVNGRH 660 HE+TH FDD GR +DK+GN+ WW N S + F+ Q+ECM+ QY NYS + + VNG + Sbjct: 613 HEITHGFDDNGRNFDKNGNMMDWWSNFSTQHFREQSECMIYQYGNYSWDLADEQNVNGFN 672 Query: 661 TLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESS 720 TLGENIADNGG++ AY+AY W+ + G + LP L LT+ QLFF+ +AQVWC PE + Sbjct: 673 TLGENIADNGGVRQAYKAYLKWMAEGGKDQQLPGLDLTHEQLFFINYAQVWCGSYRPEFA 732 Query: 721 HEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 767 + + TD HSP ++RV+GSL N F++ F C G+PM+P +C VW Sbjct: 733 IQSIKTDVHSPLKYRVLGSLQNLAAFADTFHCARGTPMHPKERCRVW 779 >gi|116256333 membrane metallo-endopeptidase [Homo sapiens] Length = 750 Score = 541 bits (1393), Expect = e-153 Identities = 290/747 (38%), Positives = 429/747 (57%), Gaps = 32/747 (4%) Query: 44 VNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVS 103 +N P+ QR W T +E L VLV+LL V +A Y T +C S C+ Sbjct: 13 INTPKPKKKQR-W---TPLEISLSVLVLLLTIIAVTMIAL----YATYDDGICKSSDCIK 64 Query: 104 VTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLEN 163 + ++ +MD T +PC DFF YACGGW+K N +P+ SR+G F L + + ++K +L+ Sbjct: 65 SAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQE 124 Query: 164 STASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNI-TGPW-----AKDNF 217 A +KA+ YR+C+NE+ I+ +PL++L+ + GW + T W A Sbjct: 125 PKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTA 184 Query: 218 QDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTG 277 + + + + Y +++V D KNS ++VI +DQ LGLPSRDYY ++ T Sbjct: 185 EKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTA 244 Query: 278 YLNYMVQLGKLLGGG-----DEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVT 332 Y+++M+ + +L+ DE + +M ++++ E +AN T E R D L+Y+K+T Sbjct: 245 YVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMT 304 Query: 333 AAELQTL------APAINWLPFLNTIFYPVEIN--ESEPIVVYDKEYLEQISTLINTTDR 384 A++Q +WL F N I V I+ E +VVY EYL ++ ++ Sbjct: 305 LAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSA 364 Query: 385 CLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFAL 444 L N M W + S L + ++++ F + +YGT W+ C + N+ A+ Sbjct: 365 RDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETAT-WRRCANYVNGNMENAV 423 Query: 445 GPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYP 504 G ++V+A FA +SK + ++I +I++ F ++L L WMD ET+K A+EKA AI IGYP Sbjct: 424 GRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYP 483 Query: 505 NFIM-DPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVN 563 + I+ + +L+ + + D YFEN ++ FS +LR+ ++D+W +VN Sbjct: 484 DDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVN 543 Query: 564 AYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNL 623 A+YS +N+IVFPAGILQ PF++ +LN+GGIG+V+GHE+TH FDD GR ++KDG+L Sbjct: 544 AFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDL 603 Query: 624 RPWWKNSSVEAFKRQTECMVEQYSNYS---VNGEPVNGRHTLGENIADNGGLKAAYRAYQ 680 WW S FK Q++CMV QY N+S G+ +NG +TLGENIADNGGL AYRAYQ Sbjct: 604 VDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQ 663 Query: 681 NWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSL 740 N++KKNG E LP L L + QLFFL FAQVWC PE + + TD HSP FR+IG+L Sbjct: 664 NYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTL 723 Query: 741 SNSKEFSEHFRCPPGSPMNPPHKCEVW 767 NS EFSE F C S MNP KC VW Sbjct: 724 QNSAEFSEAFHCRKNSYMNPEKKCRVW 750 >gi|116256331 membrane metallo-endopeptidase [Homo sapiens] Length = 750 Score = 541 bits (1393), Expect = e-153 Identities = 290/747 (38%), Positives = 429/747 (57%), Gaps = 32/747 (4%) Query: 44 VNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVS 103 +N P+ QR W T +E L VLV+LL V +A Y T +C S C+ Sbjct: 13 INTPKPKKKQR-W---TPLEISLSVLVLLLTIIAVTMIAL----YATYDDGICKSSDCIK 64 Query: 104 VTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLEN 163 + ++ +MD T +PC DFF YACGGW+K N +P+ SR+G F L + + ++K +L+ Sbjct: 65 SAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQE 124 Query: 164 STASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNI-TGPW-----AKDNF 217 A +KA+ YR+C+NE+ I+ +PL++L+ + GW + T W A Sbjct: 125 PKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTA 184 Query: 218 QDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTG 277 + + + + Y +++V D KNS ++VI +DQ LGLPSRDYY ++ T Sbjct: 185 EKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTA 244 Query: 278 YLNYMVQLGKLLGGG-----DEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVT 332 Y+++M+ + +L+ DE + +M ++++ E +AN T E R D L+Y+K+T Sbjct: 245 YVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMT 304 Query: 333 AAELQTL------APAINWLPFLNTIFYPVEIN--ESEPIVVYDKEYLEQISTLINTTDR 384 A++Q +WL F N I V I+ E +VVY EYL ++ ++ Sbjct: 305 LAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSA 364 Query: 385 CLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFAL 444 L N M W + S L + ++++ F + +YGT W+ C + N+ A+ Sbjct: 365 RDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETAT-WRRCANYVNGNMENAV 423 Query: 445 GPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYP 504 G ++V+A FA +SK + ++I +I++ F ++L L WMD ET+K A+EKA AI IGYP Sbjct: 424 GRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYP 483 Query: 505 NFIM-DPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVN 563 + I+ + +L+ + + D YFEN ++ FS +LR+ ++D+W +VN Sbjct: 484 DDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVN 543 Query: 564 AYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNL 623 A+YS +N+IVFPAGILQ PF++ +LN+GGIG+V+GHE+TH FDD GR ++KDG+L Sbjct: 544 AFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDL 603 Query: 624 RPWWKNSSVEAFKRQTECMVEQYSNYS---VNGEPVNGRHTLGENIADNGGLKAAYRAYQ 680 WW S FK Q++CMV QY N+S G+ +NG +TLGENIADNGGL AYRAYQ Sbjct: 604 VDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQ 663 Query: 681 NWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSL 740 N++KKNG E LP L L + QLFFL FAQVWC PE + + TD HSP FR+IG+L Sbjct: 664 NYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTL 723 Query: 741 SNSKEFSEHFRCPPGSPMNPPHKCEVW 767 NS EFSE F C S MNP KC VW Sbjct: 724 QNSAEFSEAFHCRKNSYMNPEKKCRVW 750 >gi|116256327 membrane metallo-endopeptidase [Homo sapiens] Length = 750 Score = 541 bits (1393), Expect = e-153 Identities = 290/747 (38%), Positives = 429/747 (57%), Gaps = 32/747 (4%) Query: 44 VNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVS 103 +N P+ QR W T +E L VLV+LL V +A Y T +C S C+ Sbjct: 13 INTPKPKKKQR-W---TPLEISLSVLVLLLTIIAVTMIAL----YATYDDGICKSSDCIK 64 Query: 104 VTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLEN 163 + ++ +MD T +PC DFF YACGGW+K N +P+ SR+G F L + + ++K +L+ Sbjct: 65 SAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQE 124 Query: 164 STASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNI-TGPW-----AKDNF 217 A +KA+ YR+C+NE+ I+ +PL++L+ + GW + T W A Sbjct: 125 PKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTA 184 Query: 218 QDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTG 277 + + + + Y +++V D KNS ++VI +DQ LGLPSRDYY ++ T Sbjct: 185 EKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTA 244 Query: 278 YLNYMVQLGKLLGGG-----DEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVT 332 Y+++M+ + +L+ DE + +M ++++ E +AN T E R D L+Y+K+T Sbjct: 245 YVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMT 304 Query: 333 AAELQTL------APAINWLPFLNTIFYPVEIN--ESEPIVVYDKEYLEQISTLINTTDR 384 A++Q +WL F N I V I+ E +VVY EYL ++ ++ Sbjct: 305 LAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSA 364 Query: 385 CLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFAL 444 L N M W + S L + ++++ F + +YGT W+ C + N+ A+ Sbjct: 365 RDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETAT-WRRCANYVNGNMENAV 423 Query: 445 GPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYP 504 G ++V+A FA +SK + ++I +I++ F ++L L WMD ET+K A+EKA AI IGYP Sbjct: 424 GRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYP 483 Query: 505 NFIM-DPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVN 563 + I+ + +L+ + + D YFEN ++ FS +LR+ ++D+W +VN Sbjct: 484 DDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVN 543 Query: 564 AYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNL 623 A+YS +N+IVFPAGILQ PF++ +LN+GGIG+V+GHE+TH FDD GR ++KDG+L Sbjct: 544 AFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDL 603 Query: 624 RPWWKNSSVEAFKRQTECMVEQYSNYS---VNGEPVNGRHTLGENIADNGGLKAAYRAYQ 680 WW S FK Q++CMV QY N+S G+ +NG +TLGENIADNGGL AYRAYQ Sbjct: 604 VDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQ 663 Query: 681 NWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSL 740 N++KKNG E LP L L + QLFFL FAQVWC PE + + TD HSP FR+IG+L Sbjct: 664 NYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTL 723 Query: 741 SNSKEFSEHFRCPPGSPMNPPHKCEVW 767 NS EFSE F C S MNP KC VW Sbjct: 724 QNSAEFSEAFHCRKNSYMNPEKKCRVW 750 >gi|116256329 membrane metallo-endopeptidase [Homo sapiens] Length = 750 Score = 541 bits (1393), Expect = e-153 Identities = 290/747 (38%), Positives = 429/747 (57%), Gaps = 32/747 (4%) Query: 44 VNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVS 103 +N P+ QR W T +E L VLV+LL V +A Y T +C S C+ Sbjct: 13 INTPKPKKKQR-W---TPLEISLSVLVLLLTIIAVTMIAL----YATYDDGICKSSDCIK 64 Query: 104 VTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLEN 163 + ++ +MD T +PC DFF YACGGW+K N +P+ SR+G F L + + ++K +L+ Sbjct: 65 SAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQE 124 Query: 164 STASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNI-TGPW-----AKDNF 217 A +KA+ YR+C+NE+ I+ +PL++L+ + GW + T W A Sbjct: 125 PKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTA 184 Query: 218 QDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTG 277 + + + + Y +++V D KNS ++VI +DQ LGLPSRDYY ++ T Sbjct: 185 EKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTA 244 Query: 278 YLNYMVQLGKLLGGG-----DEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVT 332 Y+++M+ + +L+ DE + +M ++++ E +AN T E R D L+Y+K+T Sbjct: 245 YVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMT 304 Query: 333 AAELQTL------APAINWLPFLNTIFYPVEIN--ESEPIVVYDKEYLEQISTLINTTDR 384 A++Q +WL F N I V I+ E +VVY EYL ++ ++ Sbjct: 305 LAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSA 364 Query: 385 CLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFAL 444 L N M W + S L + ++++ F + +YGT W+ C + N+ A+ Sbjct: 365 RDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETAT-WRRCANYVNGNMENAV 423 Query: 445 GPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYP 504 G ++V+A FA +SK + ++I +I++ F ++L L WMD ET+K A+EKA AI IGYP Sbjct: 424 GRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYP 483 Query: 505 NFIM-DPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVN 563 + I+ + +L+ + + D YFEN ++ FS +LR+ ++D+W +VN Sbjct: 484 DDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVN 543 Query: 564 AYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNL 623 A+YS +N+IVFPAGILQ PF++ +LN+GGIG+V+GHE+TH FDD GR ++KDG+L Sbjct: 544 AFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDL 603 Query: 624 RPWWKNSSVEAFKRQTECMVEQYSNYS---VNGEPVNGRHTLGENIADNGGLKAAYRAYQ 680 WW S FK Q++CMV QY N+S G+ +NG +TLGENIADNGGL AYRAYQ Sbjct: 604 VDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQ 663 Query: 681 NWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSL 740 N++KKNG E LP L L + QLFFL FAQVWC PE + + TD HSP FR+IG+L Sbjct: 664 NYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTL 723 Query: 741 SNSKEFSEHFRCPPGSPMNPPHKCEVW 767 NS EFSE F C S MNP KC VW Sbjct: 724 QNSAEFSEAFHCRKNSYMNPEKKCRVW 750 >gi|157426891 endothelin converting enzyme-like 1 [Homo sapiens] Length = 775 Score = 532 bits (1371), Expect = e-151 Identities = 281/754 (37%), Positives = 436/754 (57%), Gaps = 25/754 (3%) Query: 33 SEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAA-LGIQYQT- 90 + G + P G + +G R R + ++ ++ AAGL A LAA L ++Y Sbjct: 28 ARGASLPPGFPLGAARSATGARSGLPRWNRREVCLLSGLVFAAGLCAILAAMLALKYLGP 87 Query: 91 ------RSPSVCLSEACVSVTSSILSS-MDPTVDPCHDFFSYACGGWIKANPVPDGHSRW 143 P C + + L++ +D ++DPC DF+S+ACGGW++ + +PD + Sbjct: 88 VAAGGGACPEGCPERKAFARAARFLAANLDASIDPCQDFYSFACGGWLRRHAIPDDKLTY 147 Query: 144 GTFSNLWEHNQAIIKHLLENSTASVS-EAERKAQVYYRACMNETRIEELRAKPLMELIER 202 GT + + E N+ ++ LL A+RK + ++R+C++ IE L +P++E+IE Sbjct: 148 GTIAAIGEQNEERLRRLLARPGGGPGGAAQRKVRAFFRSCLDMREIERLGPRPMLEVIED 207 Query: 203 LGGWNITGPW------AKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSG 256 GGW++ G A+ + L Y + FS+ VS D +NS+ VI++DQ G Sbjct: 208 CGGWDLGGAEERPGVAARWDLNRLLYKAQGVYSAAALFSLTVSLDDRNSSRYVIRIDQDG 267 Query: 257 LGLPSRDYYLNKTEN-EKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANIT 315 L LP R YL + E+ EK+L Y +M ++ LLG +A+ + Q+IL E LANIT Sbjct: 268 LTLPERTLYLAQDEDSEKILAAYRVFMERVLSLLGA---DAVEQKAQEILQVEQQLANIT 324 Query: 316 IPQ--EKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLE 373 + + + RRD +Y+KVT +LQ + P + W L+ IF + +E E +V+ +Y++ Sbjct: 325 VSEHDDLRRDVSSMYNKVTLGQLQKITPHLRWKWLLDQIFQE-DFSEEEEVVLLATDYMQ 383 Query: 374 QISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCV 433 Q+S LI +T +L+NY++W +V S L F++A + + M G+ K + C+ Sbjct: 384 QVSQLIRSTPHRVLHNYLVWRVVVVLSEHLSPPFREALHELAQEMEGSDKP-QELARVCL 442 Query: 434 SDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEK 493 + G ALG +FV F+ SK+ +++ +IK + L L WMD ETR +A+ K Sbjct: 443 GQANRHFGMALGALFVHEHFSAASKAKVQQLVEDIKYILGQRLEELDWMDAETRAAARAK 502 Query: 494 ADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRD 553 + M+GYP+F++ P +DK + ++ YF+N + FS +++ ++R+ ++ Sbjct: 503 LQYMMVMVGYPDFLLKPDAVDKEY-EFEVHEKTYFKNILNSIRFSIQLSVKKIRQEVDKS 561 Query: 554 QWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQ 613 W + P +NAYY P KN++VFPAGILQ Y P++LN+GGIG ++GHELTH +DD Sbjct: 562 TWLLPPQALNAYYLPNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDW 621 Query: 614 GREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLK 673 G +YD+ GNL WW +S F R+ EC+V Y N++V + VNG+HTLGENIAD GGLK Sbjct: 622 GGQYDRSGNLLHWWTEASYSRFLRKAECIVRLYDNFTVYNQRVNGKHTLGENIADMGGLK 681 Query: 674 AAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSR 733 AY AYQ WV+++G EH LP L T++QLFF+ FAQ WC R +S + ++TD H+P Sbjct: 682 LAYHAYQKWVREHGPEHPLPRLKYTHDQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEH 741 Query: 734 FRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 767 +RV+GS+S +EF F CP SPMNP HKC VW Sbjct: 742 YRVLGSVSQFEEFGRAFHCPKDSPMNPAHKCSVW 775 >gi|90403592 phosphate-regulating neutral endopeptidase [Homo sapiens] Length = 749 Score = 472 bits (1214), Expect = e-133 Identities = 271/722 (37%), Positives = 401/722 (55%), Gaps = 30/722 (4%) Query: 73 LAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIK 132 L G + L + G+ CL C+ ++ILS ++ +VDPC +FF +AC GWI Sbjct: 31 LVLGTILFLVSQGLLSLQAKQEYCLKPECIEAAAAILSKVNLSVDPCDNFFRFACDGWIS 90 Query: 133 ANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASV--SEAERKAQVYYRACMNETRIEE 190 NP+P+ +G + L + +K LLE S + +EA +KA++ Y +CMNE IE+ Sbjct: 91 NNPIPEDMPSYGVYPWLRHNVDLKLKELLEKSISRRRDTEAIQKAKILYSSCMNEKAIEK 150 Query: 191 LRAKPLMELIERLG-GWNIT-------GPWAKDNFQ--DTLQVVTAHYRTSPFFSVYVSA 240 AKPL+ ++ W + G W++ F TL Y S F +YVS Sbjct: 151 ADAKPLLHILRHSPFRWPVLESNIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSP 210 Query: 241 DSKNSNSNVIQVDQSGLGLPSRDYYL-NKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRP 299 D K SN +++++DQ+ L L R+ YL N TE + +MV LLG A Sbjct: 211 DDKASNEHILKLDQATLSLAVREDYLDNSTEAKSYRDALYKFMVDTAVLLGANSSRA-EH 269 Query: 300 QMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFL----NTIFYP 355 M+ +L E +A I IP E R E + Y+K+ +EL + P +WL ++ +T YP Sbjct: 270 DMKSVLRLEIKIAEIMIPHENRTSEAM-YNKMNISELSAMIPQFDWLGYIKKVIDTRLYP 328 Query: 356 --VEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEK 413 +I+ SE +VV +Y + + ++ + + + NY++W +V L +RFQ + Sbjct: 329 HLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVWRMVYSRIPNLSRRFQYRWLE 388 Query: 414 FMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFE 473 F V+ GT T LP+W CV+ E+ L + +G MFV F ED K + E++ ++ AF Sbjct: 389 FSRVIQGTT-TLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFI 447 Query: 474 ESLSTL-KWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAM 532 + L +WMD T++ AKEKA A+ +GYP FIM+ +++ YF N + Sbjct: 448 DMLEKENEWMDAGTKRKAKEKARAVLAKVGYPEFIMNDTHVNEDLKAIKFSEADYFGNVL 507 Query: 533 RFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSS-PK 591 + + + LRKA + +W P VNA+YS + N+I FPAG LQ PF+ + P+ Sbjct: 508 QTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPR 567 Query: 592 ALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNY-- 649 +L++G IGV+VGHE TH FD+ GR+YDK+GNL PWW S E FK +T+CM+ QYSNY Sbjct: 568 SLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSTESEEKFKEKTKCMINQYSNYYW 627 Query: 650 SVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWV--KKNGAEHS-LPTLGLTNNQLFFLG 706 G V G+ TLGENIADNGGL+ A+RAY+ W+ ++ G E LP + TNNQLFFL Sbjct: 628 KKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGLEEPLLPGITFTNNQLFFLS 687 Query: 707 FAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMN-PPHKCE 765 +A V C+ PE++ E + HSP +FRV G++SN +EF + F CPP S MN C Sbjct: 688 YAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPPNSTMNRGMDSCR 747 Query: 766 VW 767 +W Sbjct: 748 LW 749 >gi|4557691 Kell blood group, metallo-endopeptidase [Homo sapiens] Length = 732 Score = 351 bits (901), Expect = 1e-96 Identities = 230/733 (31%), Positives = 359/733 (48%), Gaps = 49/733 (6%) Query: 49 PRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGI-QYQTRSPSVCLSEACVSVTSS 107 P G R WA +V L +L GL+ C + L +Q P C + C+ + Sbjct: 35 PVEGSRPWAVARRV------LTAILILGLLLCFSVLLFYNFQNCGPRPCETSVCLDLRDH 88 Query: 108 ILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLE-NSTA 166 L+S + +V PC DFFS+ACG + N +F L N+ ++ +LE ++ Sbjct: 89 YLASGNTSVAPCTDFFSFACGRAKETN---------NSFQELATKNKNRLRRILEVQNSW 139 Query: 167 SVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTA 226 E KA +Y +CM+ IE PL ++IE LGGW I+G W NF TL+++ + Sbjct: 140 HPGSGEEKAFQFYNSCMDTLAIEAAGTGPLRQVIEELGGWRISGKWTSLNFNRTLRLLMS 199 Query: 227 HYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEK----VLTGYLNYM 282 Y PFF Y+ + ++ VIQ+DQ P D L + + +K + YL Y+ Sbjct: 200 QYGHFPFFRAYLGPHPASPHTPVIQIDQ-----PEFDVPLKQDQEQKIYAQIFREYLTYL 254 Query: 283 VQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPA 342 QLG LL GGD ++ + + L P E+RR + ++ VT +L+ +APA Sbjct: 255 NQLGTLL-GGDPSKVQEHSSLSISITSRLFQFLRPLEQRRAQGKLFQMVTIDQLKEMAPA 313 Query: 343 INWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLIN---TTDRCLLNNYMIWNLVRKT 399 I+WL L F P+ ++ S+ +VV+D EYL+ +S L+ R L ++MI LV Sbjct: 314 IDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNMSQLVEEMLLKQRDFLQSHMILGLVVTL 373 Query: 400 SSFLDQRFQDA----DEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAE 455 S LD +FQ+A +K E+ PRW CV +T L +FV+ F Sbjct: 374 SPALDSQFQEARRKLSQKLRELTEQPPMPARPRWMKCVEETGTFFEPTLAALFVREAFGP 433 Query: 456 DSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDK 515 ++S A ++ I+ A L L WM+EET+ A++K + +G + + P+ + Sbjct: 434 STRSAAMKLFTAIRDALITRLRNLPWMNEETQNMAQDKVAQLQVEMGASEWALKPELARQ 493 Query: 516 VFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVF 575 +ND + R+ L+ P + +W ++P VNAYYS + + +VF Sbjct: 494 EYNDIQLGSSFLQSVLSCVRSLRARIVQSFLQPHP-QHRWKVSPWDVNAYYSVSDHVVVF 552 Query: 576 PAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAF 635 PAG+LQ PF+ P+A+NFG G ++ HEL H F + G ++ EA Sbjct: 553 PAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIF----YQLLLPGGCLACDNHALQEAH 608 Query: 636 KRQTECMVEQYSNYSV-NGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPT 694 C+ Y+ + + + N T EN AD GGL A +AY + ++ E LP+ Sbjct: 609 L----CLKRHYAAFPLPSRTSFNDSLTFLENAADVGGLAIALQAYSKRLLRHHGETVLPS 664 Query: 695 LGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPP 754 L L+ Q+FF +AQV C +P+ SH D HSP RV G LS++ F+ +FRC Sbjct: 665 LDLSPQQIFFRSYAQVMCRKPSPQDSH-----DTHSPPHLRVHGPLSSTPAFARYFRCAR 719 Query: 755 GSPMNPPHKCEVW 767 G+ +NP +C++W Sbjct: 720 GALLNPSSRCQLW 732 >gi|109826564 neurofibromin isoform 1 [Homo sapiens] Length = 2839 Score = 32.0 bits (71), Expect = 2.2 Identities = 15/39 (38%), Positives = 22/39 (56%) Query: 448 FVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEET 486 + + TFA S TE +LEI +A + T KW+D+ T Sbjct: 2192 YERETFALTSLETVTEALLEIMEACMRDIPTCKWLDQWT 2230 >gi|4557793 neurofibromin isoform 2 [Homo sapiens] Length = 2818 Score = 32.0 bits (71), Expect = 2.2 Identities = 15/39 (38%), Positives = 22/39 (56%) Query: 448 FVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEET 486 + + TFA S TE +LEI +A + T KW+D+ T Sbjct: 2171 YERETFALTSLETVTEALLEIMEACMRDIPTCKWLDQWT 2209 >gi|134152674 rabaptin, RAB GTPase binding effector protein 1 isoform 2 [Homo sapiens] Length = 829 Score = 31.6 bits (70), Expect = 2.9 Identities = 25/91 (27%), Positives = 45/91 (49%), Gaps = 8/91 (8%) Query: 403 LDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIAT 462 L+Q F KF E +Y K+ L R + +++LG ++ E+ K+IAT Sbjct: 35 LEQEFNQKRAKFKE-LYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIAT 93 Query: 463 -------EIILEIKKAFEESLSTLKWMDEET 486 E I E+K+ + E +++L+ + +ET Sbjct: 94 VSENTKQEAIDEVKRQWREEVASLQAVMKET 124 >gi|31377798 rabaptin, RAB GTPase binding effector protein 1 isoform 1 [Homo sapiens] Length = 862 Score = 31.6 bits (70), Expect = 2.9 Identities = 25/91 (27%), Positives = 45/91 (49%), Gaps = 8/91 (8%) Query: 403 LDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIAT 462 L+Q F KF E +Y K+ L R + +++LG ++ E+ K+IAT Sbjct: 35 LEQEFNQKRAKFKE-LYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIAT 93 Query: 463 -------EIILEIKKAFEESLSTLKWMDEET 486 E I E+K+ + E +++L+ + +ET Sbjct: 94 VSENTKQEAIDEVKRQWREEVASLQAVMKET 124 >gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo sapiens] Length = 1939 Score = 30.8 bits (68), Expect = 4.9 Identities = 15/41 (36%), Positives = 28/41 (68%), Gaps = 1/41 (2%) Query: 455 EDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKAD 495 ++S+S++TE+ +IK A+EESL L+ + E + +E +D Sbjct: 1476 KESRSLSTELF-KIKNAYEESLDQLETLKRENKNLQQEISD 1515 >gi|154744870 zinc finger protein 574 [Homo sapiens] Length = 896 Score = 30.4 bits (67), Expect = 6.5 Identities = 21/65 (32%), Positives = 32/65 (49%), Gaps = 7/65 (10%) Query: 137 PDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPL 196 PD + +FSNLW+H K + A+V + +A+ + ET +E L PL Sbjct: 825 PDCGKSYRSFSNLWKHR----KTHQQQHQAAVRQQLAEAEAAVGLAVMETAVEAL---PL 877 Query: 197 MELIE 201 +E IE Sbjct: 878 VEAIE 882 >gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo sapiens] Length = 1939 Score = 30.0 bits (66), Expect = 8.4 Identities = 14/41 (34%), Positives = 28/41 (68%), Gaps = 1/41 (2%) Query: 455 EDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKAD 495 ++S+S++TE+ ++K A+EESL L+ + E + +E +D Sbjct: 1476 KESRSLSTELF-KVKNAYEESLDHLETLKRENKNLQQEISD 1515 >gi|50345831 forkhead box J3 [Homo sapiens] Length = 622 Score = 30.0 bits (66), Expect = 8.4 Identities = 15/49 (30%), Positives = 27/49 (55%), Gaps = 4/49 (8%) Query: 466 LEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNM----IGYPNFIMDP 510 L + E SL+++ W+ + T ++A +K+DA N I N ++DP Sbjct: 14 LRMTSELESSLTSMDWLPQLTMRAAIQKSDATQNAHGTGISKKNALLDP 62 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.318 0.133 0.406 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 29,902,171 Number of Sequences: 37866 Number of extensions: 1353858 Number of successful extensions: 3356 Number of sequences better than 10.0: 24 Number of HSP's better than 10.0 without gapping: 18 Number of HSP's successfully gapped in prelim test: 6 Number of HSP's that attempted gapping in prelim test: 3261 Number of HSP's gapped (non-prelim): 30 length of query: 767 length of database: 18,247,518 effective HSP length: 110 effective length of query: 657 effective length of database: 14,082,258 effective search space: 9252043506 effective search space used: 9252043506 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.