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Search of human proteins with 157384932
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157384932 hypothetical protein LOC390594 [Homo sapiens]
(458 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157384932 hypothetical protein LOC390594 [Homo sapiens] 934 0.0
gi|55749726 kelch domain containing 5 [Homo sapiens] 125 6e-29
gi|206597556 kelch domain containing 7B [Homo sapiens] 94 3e-19
gi|116089333 kelch domain containing 7A [Homo sapiens] 92 7e-19
gi|24308181 kelch-like 9 [Homo sapiens] 91 2e-18
gi|7662260 kelch repeat and BTB (POZ) domain containing 11 [Homo... 85 1e-16
gi|45643138 kelch-like 13 [Homo sapiens] 84 2e-16
gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo... 82 1e-15
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 80 4e-15
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 80 4e-15
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 80 4e-15
gi|11056006 kelch-like 12 [Homo sapiens] 78 2e-14
gi|34101268 kelch-like 8 [Homo sapiens] 77 4e-14
gi|166235129 kelch-like 3 [Homo sapiens] 75 9e-14
gi|38194229 kelch-like 17 [Homo sapiens] 75 1e-13
gi|55741643 kelch-like 14 [Homo sapiens] 75 1e-13
gi|31542246 kelch-like 36 [Homo sapiens] 74 2e-13
gi|24475847 influenza virus NS1A binding protein [Homo sapiens] 72 8e-13
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 70 3e-12
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 70 3e-12
gi|40807500 kelch-like 20 [Homo sapiens] 69 7e-12
gi|158508542 kelch-like 33 [Homo sapiens] 66 6e-11
gi|14780904 kelch-like 1 protein [Homo sapiens] 65 1e-10
gi|156616301 kelch-like 32 [Homo sapiens] 65 2e-10
gi|24432026 kelch-like [Homo sapiens] 64 3e-10
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 63 5e-10
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 63 5e-10
gi|11545731 gigaxonin [Homo sapiens] 62 8e-10
gi|88196794 kelch-like 35 [Homo sapiens] 62 8e-10
gi|23397572 kelch-like 34 [Homo sapiens] 62 8e-10
>gi|157384932 hypothetical protein LOC390594 [Homo sapiens]
Length = 458
Score = 934 bits (2414), Expect = 0.0
Identities = 458/458 (100%), Positives = 458/458 (100%)
Query: 1 MARGPQTLVQVWVGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRA 60
MARGPQTLVQVWVGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRA
Sbjct: 1 MARGPQTLVQVWVGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRA 60
Query: 61 TLQVLRGDRPALAAEDELLQAVECAAFLQAPALARFLEHNLTSDNCALLCDAAAAFGLRD 120
TLQVLRGDRPALAAEDELLQAVECAAFLQAPALARFLEHNLTSDNCALLCDAAAAFGLRD
Sbjct: 61 TLQVLRGDRPALAAEDELLQAVECAAFLQAPALARFLEHNLTSDNCALLCDAAAAFGLRD 120
Query: 121 VFHSAALFICDGERELAAELALPEARAYVAALRPSSYAAVSTHTPAPGFLEDASRTLCYL 180
VFHSAALFICDGERELAAELALPEARAYVAALRPSSYAAVSTHTPAPGFLEDASRTLCYL
Sbjct: 121 VFHSAALFICDGERELAAELALPEARAYVAALRPSSYAAVSTHTPAPGFLEDASRTLCYL 180
Query: 181 DEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGASKEVVELGFCYDPDGGTWHE 240
DEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGASKEVVELGFCYDPDGGTWHE
Sbjct: 181 DEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGASKEVVELGFCYDPDGGTWHE 240
Query: 241 FPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPC 300
FPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPC
Sbjct: 241 FPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPC 300
Query: 301 AQACGRLFVCLWRPADTTAVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRNGP 360
AQACGRLFVCLWRPADTTAVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRNGP
Sbjct: 301 AQACGRLFVCLWRPADTTAVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRNGP 360
Query: 361 SDDFLHCAIDCLNLATGQWTALPGQFVNSKGALFTAVVRGDTVYTVNRMFTLLYAIEGGT 420
SDDFLHCAIDCLNLATGQWTALPGQFVNSKGALFTAVVRGDTVYTVNRMFTLLYAIEGGT
Sbjct: 361 SDDFLHCAIDCLNLATGQWTALPGQFVNSKGALFTAVVRGDTVYTVNRMFTLLYAIEGGT 420
Query: 421 WRLLREKAGFPRPGSLQTFLLRLPPGAPGPVTSTTAEL 458
WRLLREKAGFPRPGSLQTFLLRLPPGAPGPVTSTTAEL
Sbjct: 421 WRLLREKAGFPRPGSLQTFLLRLPPGAPGPVTSTTAEL 458
>gi|55749726 kelch domain containing 5 [Homo sapiens]
Length = 505
Score = 125 bits (315), Expect = 6e-29
Identities = 125/475 (26%), Positives = 203/475 (42%), Gaps = 76/475 (16%)
Query: 6 QTLVQVWVGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEV------RLGVLSAGGFR 59
+ +VQ+ + + + + L+E +FR L+RSGMRE + E +L LSA G R
Sbjct: 4 EEMVQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREALSQEAGGPEVQQLRGLSAPGLR 63
Query: 60 ATLQVL-------------RGDRPALAAEDE-------LLQAVECAAFLQAPALARFLEH 99
L + RG++ EDE L + VE A+FLQ +L + L
Sbjct: 64 LVLDFINAGGAREGWLLGPRGEKGGGVDEDEEMDEVSLLSELVEAASFLQVTSLLQLLLS 123
Query: 100 NLTSDNCALLCDAAAAFGLRDVFHSAALFICDGERELAAE-----LALPEARAYVAALRP 154
+ +NC + A +GL D+ + F+ E+ + L P +L+
Sbjct: 124 QVRLNNCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLLGSPPQAPGDVSLKQ 183
Query: 155 SSYAAVSTHTP-------------APGFLEDASRTLCYLDEEEDAWRTLAA-LPLEASTL 200
A T TP AP + ++ +E + W LA LP + +
Sbjct: 184 RLREARMTGTPVLVALGDFLGGPLAPHPYQGEPPSMLRYEEMTERWFPLANNLPPDLVNV 243
Query: 201 LA-GVATLGNKLYIVGGVRGASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGR 259
G A L N L+IVGG R S+E+ Y+P W + S +Q R + L + +
Sbjct: 244 RGYGSAILDNYLFIVGGYRITSQEI-SAAHSYNPSTNEWLQVASMNQKRSNFKLVAVNSK 302
Query: 260 LYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVC-LWRPADTT 318
LYAIGG+ +S+VE Y+P W+FVA LP P A + G+++V + D
Sbjct: 303 LYAIGGQ----AVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRN 358
Query: 319 A-VVEYAVRTDAWLPV----AELRRPQSYGHCMVAHRDSLYVV-----------RNGPSD 362
+++Y +D W +R+ Q MV+ +++Y+V R+ S+
Sbjct: 359 MNILQYCPSSDMWTLFETCDVHIRKQQ-----MVSVEETIYIVGGCLHELGPNRRSSQSE 413
Query: 363 DFLHCAIDCLNLATGQWTALPGQFVNSKGALFTAVVRGDTVYTVNRMFTLLYAIE 417
D L + N T QW L + + G T + D +Y ++R TL ++E
Sbjct: 414 DML--TVQSYNTVTRQWLYLK-ENTSKSGLNLTCALHNDGIYIMSRDVTLSTSLE 465
>gi|206597556 kelch domain containing 7B [Homo sapiens]
Length = 594
Score = 93.6 bits (231), Expect = 3e-19
Identities = 93/309 (30%), Positives = 123/309 (39%), Gaps = 53/309 (17%)
Query: 158 AAVSTHTPAPGFLEDASRTLCYLDEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGV 217
AA P P L + E+ WR L +P EA G+ T+ N L++ GG+
Sbjct: 310 AAAPVSLPLPAHLH-------VFNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGI 362
Query: 218 RGASKEVV--ELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSV 275
RG+ + V FCY+P W + Q R L DG LYAIGGE + S+
Sbjct: 363 RGSGAKAVCSNEVFCYNPLTNIWSQVRPMQQARAQLKLVALDGLLYAIGGEC----LYSM 418
Query: 276 ERYDPAAGCWSFVADLPQPAAGVPCAQ---AC--------GRLFVCLWRPADTTAVVEYA 324
E YDP W+ A P PA P A AC G LF L R Y+
Sbjct: 419 ECYDPRTDAWTPRA--PLPAGTFPVAHEAVACRGDIYVTGGHLFYRLLR---------YS 467
Query: 325 VRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRNGPSDDF-----LHCAIDCLNLATGQW 379
DAW P S H R S V G F + A+ N TG W
Sbjct: 468 PVKDAWDEC-----PYSASH----RRSSDIVALGGFLYRFDLLRGVGAAVMRYNTVTGSW 518
Query: 380 TALPGQFVNSKGALFTAVVRGDTVYTVNRMFTLLYAIEGGTWRL-LREKAGFP--RPGSL 436
+ + + L + G+T+Y +N T + + GGT + +E FP G L
Sbjct: 519 SRAASLPLPAPAPLHCTTL-GNTIYCLNPQVTATFTVSGGTAQFQAKELQPFPLGSTGVL 577
Query: 437 QTFLLRLPP 445
F+L LPP
Sbjct: 578 SPFILTLPP 586
>gi|116089333 kelch domain containing 7A [Homo sapiens]
Length = 777
Score = 92.4 bits (228), Expect = 7e-19
Identities = 55/141 (39%), Positives = 71/141 (50%), Gaps = 9/141 (6%)
Query: 152 LRPSSYAAVSTHTPAPGFLEDASRTLCYLDEEEDAWRTLAALPLEASTLLAGVATLGNKL 211
LR Y V+ P ED+ CY D+E+D WR LA +P EA + + +L N L
Sbjct: 488 LRGRQYLVVADVCPK----EDSGGLCCY-DDEQDVWRPLARMPPEAVSRGCAICSLFNYL 542
Query: 212 YIVGGVRGASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTP 271
++V G +G + FCY+P G W E +Q R L DG LYAIGGE
Sbjct: 543 FVVSGCQGPGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVALDGHLYAIGGEC---- 598
Query: 272 ISSVERYDPAAGCWSFVADLP 292
++SVERYDP W F LP
Sbjct: 599 LNSVERYDPRLDRWDFAPPLP 619
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 91.3 bits (225), Expect = 2e-18
Identities = 74/259 (28%), Positives = 114/259 (44%), Gaps = 28/259 (10%)
Query: 174 SRTLCYLDEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRG---ASKEVVELGFC 230
S+ L DE WR+LA P++A G+A +GN LY+VGG K V+ F
Sbjct: 314 SKELRMYDERAQEWRSLA--PMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFR 371
Query: 231 YDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVAD 290
+DP W + S ++ R L+ G LYA+GG +++VE Y+P WS+VA
Sbjct: 372 FDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAK 431
Query: 291 LPQPAAGVPCAQACGRLFVCLWRPADT--TAVVEYAVRTDAWLPVAELRRPQSYGHCMVA 348
+ +P G G +++ DT ++ + TD W+ A + + HCM
Sbjct: 432 MSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGL-HCMCT 490
Query: 349 HRDSLYVVR----NGPS--DDFLHCAIDCLNLATGQWTALPGQFVNSKGALFTAVVRGDT 402
D LYV+ G S DD L C + + QWT + A++RG +
Sbjct: 491 VGDKLYVIGGNHFRGTSDYDDVLSC--EYYSPTLDQWTPI------------AAMLRGQS 536
Query: 403 VYTVNRMFTLLYAIEGGTW 421
V +Y + G +W
Sbjct: 537 DVGVAVFENKIYVVGGYSW 555
Score = 64.3 bits (155), Expect = 2e-10
Identities = 93/422 (22%), Positives = 152/422 (36%), Gaps = 63/422 (14%)
Query: 14 GGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATLQVLRGDRPALA 73
G ++F RA++ +F+ +F GM+E ++L ++ G + + + + +L
Sbjct: 59 GDEIFPVHRAMMASASDYFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLN 118
Query: 74 AEDELLQAVECAAFLQ-APAL---ARFLEHNLTSDNCALLCDAAAAFGLRDV-------- 121
D L +E A+FLQ P L FL ++ DNC + A + L +V
Sbjct: 119 M-DNLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFI 177
Query: 122 -----------------FHSAALFICDGERELAAELALPEARAYVAALRP--SSYAA--- 159
F A + + EL L +A L YAA
Sbjct: 178 LKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKAACRWLRLEDPRMDYAAKLM 237
Query: 160 --VSTHTPAPGFLEDASRTLCYLDEEEDAWRTLAALPLEASTL-------------LAGV 204
+ P L + +T+ ++ + T L LEAS +
Sbjct: 238 KNIRFPLMTPQDLINYVQTVDFMRTD----NTCVNLLLEASNYQMMPYMQPVMQSDRTAI 293
Query: 205 ATLGNKLYIVGGVRGASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIG 264
+ L +GGV V + YD W PRY +A LY +G
Sbjct: 294 RSDSTHLVTLGGVLRQQLVVSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVG 353
Query: 265 GEFQ-----RTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVCLWRPA--DT 317
G+ +T + +V R+DP W VA L + + G L+ R A +
Sbjct: 354 GQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGEL 413
Query: 318 TAVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRNGPSDDFLHCAIDCLNLATG 377
V Y R + W VA++ P YGH + +Y + G + D + C + T
Sbjct: 414 ATVECYNPRMNEWSYVAKMSEPH-YGHAGTVYGGLMY-ISGGITHDTFQNELMCFDPDTD 471
Query: 378 QW 379
+W
Sbjct: 472 KW 473
Score = 59.7 bits (143), Expect = 5e-09
Identities = 57/203 (28%), Positives = 87/203 (42%), Gaps = 27/203 (13%)
Query: 119 RDVFHSAAL---FICDGERELAAELALPEAR-------AYVAALRPSSYAAVSTHTP--- 165
R FH +AL G R A ELA E +YVA + Y T
Sbjct: 389 RTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLM 448
Query: 166 --APGFLEDA--SRTLCYLDEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGG--VRG 219
+ G D + +C+ D + D W A P+ L + T+G+KLY++GG RG
Sbjct: 449 YISGGITHDTFQNELMCF-DPDTDKWMQKA--PMTTVRGLHCMCTVGDKLYVIGGNHFRG 505
Query: 220 ASK--EVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEF--QRTPISSV 275
S +V+ + Y P W + + + D +A F+ ++Y +GG R + V
Sbjct: 506 TSDYDDVLSCEY-YSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIV 564
Query: 276 ERYDPAAGCWSFVADLPQPAAGV 298
++YDP W V DLP+ G+
Sbjct: 565 QKYDPEKDEWHKVFDLPESLGGI 587
>gi|7662260 kelch repeat and BTB (POZ) domain containing 11 [Homo
sapiens]
Length = 623
Score = 85.1 bits (209), Expect = 1e-16
Identities = 90/314 (28%), Positives = 125/314 (39%), Gaps = 39/314 (12%)
Query: 13 VGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATLQVLRGDRPAL 72
V G+ +A +A+L +FR R +R +R+ +S R L R A
Sbjct: 146 VSGRRLRAHKAVLAARSDYFRA------RASRDV-LRVQGVSLTALRLLLADAYSGRMAG 198
Query: 73 AAEDELLQAVECAAFLQAPALAR----FLEHNLTSDNCALLCDAAAAFGLRDVFHSAALF 128
D + + V A LQ P A+ + L+ NC + AA L ++ +A F
Sbjct: 199 VRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRDAAYCF 258
Query: 129 ICD-----------------GERELAAELALPEARAYV--AALRPSSYAAVSTHTPAPGF 169
+ D ER+L L RA++ AAL P+ A S G
Sbjct: 259 MSDHYLEVLREPAVFGRLSGAERDLLLRRRLRAGRAHLLAAALGPAGERAGSRPQSPSGD 318
Query: 170 LEDASRTLCY-LDEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGASKE----V 224
+ Y WR L LP A G+ L N L++ GGV A +
Sbjct: 319 ADARGDAAVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARP 378
Query: 225 VELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGC 284
+ FCY+P +W Q R L DG LYA+GGE + SVERYDP A
Sbjct: 379 SDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGEC----LLSVERYDPRADR 434
Query: 285 WSFVADLPQPAAGV 298
W+ VA LP+ A V
Sbjct: 435 WAPVAPLPRGAFAV 448
Score = 35.4 bits (80), Expect = 0.11
Identities = 31/113 (27%), Positives = 39/113 (34%), Gaps = 13/113 (11%)
Query: 181 DEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGASKEVVELGFCYDPDGGTWHE 240
D D W +A LP A + T ++Y+ GG + YDP W E
Sbjct: 429 DPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGG------SLFYRLLKYDPRRDEWQE 482
Query: 241 FPSPHQPRYDTALAGFDGRLYAIG-----GEFQRTPIS--SVERYDPAAGCWS 286
P + DG +Y GE Q S SV RY A WS
Sbjct: 483 CPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAAGPSGVSVSRYHCLAKQWS 535
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 84.3 bits (207), Expect = 2e-16
Identities = 71/259 (27%), Positives = 114/259 (44%), Gaps = 28/259 (10%)
Query: 174 SRTLCYLDEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRG---ASKEVVELGFC 230
S+ L DE+ W++LA P++A G+A +GN LY+VGG K V+ F
Sbjct: 356 SKELRMYDEKAHEWKSLA--PMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFR 413
Query: 231 YDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVAD 290
+DP W + S ++ R L+ G LYA+GG + +VE Y+P W++VA
Sbjct: 414 FDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAK 473
Query: 291 LPQPAAGVPCAQACGRLFVCLWRPADT--TAVVEYAVRTDAWLPVAELRRPQSYGHCMVA 348
+ +P G G +++ DT ++ + TD W+ A + + HCM
Sbjct: 474 MSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGL-HCMCT 532
Query: 349 HRDSLYVVR----NGPS--DDFLHCAIDCLNLATGQWTALPGQFVNSKGALFTAVVRGDT 402
+ LYV+ G S DD L C + + QWT + A++RG +
Sbjct: 533 VGERLYVIGGNHFRGTSDYDDVLSC--EYYSPILDQWTPI------------AAMLRGQS 578
Query: 403 VYTVNRMFTLLYAIEGGTW 421
V +Y + G +W
Sbjct: 579 DVGVAVFENKIYVVGGYSW 597
Score = 55.5 bits (132), Expect = 1e-07
Identities = 57/222 (25%), Positives = 91/222 (40%), Gaps = 31/222 (13%)
Query: 119 RDVFHSAAL---FICDGERELAAELALPEAR-------AYVAALRPSSYAAVSTHTPAPG 168
R FH +AL G R A EL E YVA + Y T
Sbjct: 431 RTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVM 490
Query: 169 FLEDA------SRTLCYLDEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGG--VRGA 220
++ + L D + D W + P+ L + T+G +LY++GG RG
Sbjct: 491 YISGGITHDTFQKELMCFDPDTDKW--IQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGT 548
Query: 221 SK--EVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEF--QRTPISSVE 276
S +V+ + Y P W + + + D +A F+ ++Y +GG R + V+
Sbjct: 549 SDYDDVLSCEY-YSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQ 607
Query: 277 RYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVCLWRPADTT 318
+YDP W V DLP+ G+ +AC + ++ P +TT
Sbjct: 608 KYDPDKDEWHKVFDLPESLGGI---RAC---TLTVFPPEETT 643
Score = 44.3 bits (103), Expect = 2e-04
Identities = 88/382 (23%), Positives = 139/382 (36%), Gaps = 36/382 (9%)
Query: 18 FQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATLQVLRGDRPALAAEDE 77
F R ++ +F+ +F GM+E ++L +S G R + + + +L D
Sbjct: 105 FPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNM-DN 163
Query: 78 LLQAVECAAFLQ-APAL---ARFLEHNLTSDNCALLCDAAAAFGLRDVFHSAALFICDGE 133
L +E A+FLQ P L FL +T DNC + A + L +V F+
Sbjct: 164 LQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNF 223
Query: 134 RELAAE---LALP-EARAYVAALRPSSYAAVSTHTPAPGFLEDASRTLCYLDEEEDAWRT 189
L + L LP E A+V + + LE T +L EE
Sbjct: 224 PALLSTGEFLKLPFERLAFVLSSNSLKHCTE---------LELFKATCRWLRLEEPRMDF 274
Query: 190 LAALPLEASTLLAGVATLGNKLYIVGGVRGASKEVVELGFCYDPDGGTWHEFPSPHQPRY 249
A L L L N + V +R + V + + P
Sbjct: 275 AAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCV---NLLLEASNYQMMPYMQPVMQSD 331
Query: 250 DTALAGFDGRLYAIGGEFQRTPISSVE--RYDPAAGCWSFVADLPQPAAGVPCAQACGRL 307
TA+ L +GG ++ + S E YD A W +A + P A L
Sbjct: 332 RTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFL 391
Query: 308 FVCLWRPADTT-------AVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVV--RN 358
+V + T V + R + W+ VA L +++ H + A + LY V RN
Sbjct: 392 YVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFH-LSALKGYLYAVGGRN 450
Query: 359 GPSDDFLHCAIDCLNLATGQWT 380
+ ++C N T +WT
Sbjct: 451 AAGE---LPTVECYNPRTNEWT 469
>gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo
sapiens]
Length = 634
Score = 82.0 bits (201), Expect = 1e-15
Identities = 70/227 (30%), Positives = 104/227 (45%), Gaps = 18/227 (7%)
Query: 167 PGFLEDA-SRTLCYLDEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGG-----VRGA 220
PG E + SR + Y D E + W L +P A + VA + LY+ GG R
Sbjct: 325 PGLTEKSLSRDILYRDPE-NGWSKLTEMP--AKSFNQCVAVMDGFLYVAGGEDQNDARNQ 381
Query: 221 SKEVVELGFC-YDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYD 279
+K V FC YDP TW S +Q R +L+ F+G +YA GG ++S+E Y
Sbjct: 382 AKHAVS-NFCRYDPRFNTWIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYV 440
Query: 280 PAAGCWSFVADLPQPAAGVPCAQACGRLFVC--LWRPADTTAVVEYAVRTDAWLPVAELR 337
P+ W L A A GR+ V A + +V Y +D+W + L
Sbjct: 441 PSTNQWQPKTPLEVARCCHASAVADGRVLVTGGYIANAYSRSVCAYDPASDSWQELPNLS 500
Query: 338 RPQSYGHCMVAHRDSLYVV---RNGPSDDFLH-CAIDCLNLATGQWT 380
P+ + HC V D +YV+ + GP + + ++C + ATGQW+
Sbjct: 501 TPRGW-HCAVTLSDRVYVMGGSQLGPRGERVDVLTVECYSPATGQWS 546
Score = 55.8 bits (133), Expect = 8e-08
Identities = 41/141 (29%), Positives = 69/141 (48%), Gaps = 12/141 (8%)
Query: 168 GFLEDA-SRTLCYLDEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGV----RGASK 222
G++ +A SR++C D D+W+ L L A TL +++Y++GG RG
Sbjct: 473 GYIANAYSRSVCAYDPASDSWQELPNLSTPRGWHCA--VTLSDRVYVMGGSQLGPRGERV 530
Query: 223 EVVELGFCYDPDGGTWHEFPSPHQPRYDTA-LAGFDGRLYAIGG--EFQRTPISSVERYD 279
+V+ + CY P G W + +P Q TA ++ GR Y +GG E ++ ++ +
Sbjct: 531 DVLTVE-CYSPATGQW-SYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKKCIQCFS 588
Query: 280 PAAGCWSFVADLPQPAAGVPC 300
P W+ +LP+ GV C
Sbjct: 589 PELNEWTEDDELPEATVGVSC 609
Score = 47.8 bits (112), Expect = 2e-05
Identities = 33/123 (26%), Positives = 50/123 (40%), Gaps = 11/123 (8%)
Query: 194 PLEASTLLAGVATLGNKLYIVGG--VRGASKEVVELGFCYDPDGGTWHEFPSPHQPRYDT 251
PLE + A ++ + GG S+ V YDP +W E P+ PR
Sbjct: 451 PLEVARCCHASAVADGRVLVTGGYIANAYSRSVC----AYDPASDSWQELPNLSTPRGWH 506
Query: 252 ALAGFDGRLYAIGGEF-----QRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQACGR 306
R+Y +GG +R + +VE Y PA G WS+ A L + + GR
Sbjct: 507 CAVTLSDRVYVMGGSQLGPRGERVDVLTVECYSPATGQWSYAAPLQVGVSTAGVSALHGR 566
Query: 307 LFV 309
++
Sbjct: 567 AYL 569
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 80.1 bits (196), Expect = 4e-15
Identities = 66/234 (28%), Positives = 109/234 (46%), Gaps = 16/234 (6%)
Query: 181 DEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGASK-EVVELGFCYDPDGGTWH 239
D + W +A + L GVA L +KLY+VGG G VE CY+P TW
Sbjct: 442 DLRTNMWTPVANM--NGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVE---CYNPKTKTWS 496
Query: 240 EFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVP 299
P R+ +A +G +YA+GG + +++VER+DP A W+FVA + P + V
Sbjct: 497 VMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVG 556
Query: 300 CAQACGRLFVCLWRPADT--TAVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVV- 356
A G+L+ R + +V + T+ W A++ + + G + LY +
Sbjct: 557 VAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRG-GVGVTTWNGLLYAIG 615
Query: 357 -RNGPSDDFLHCAIDCL---NLATGQWTALPGQFVNSKGALFTAVVRGDTVYTV 406
+ P+ + DC+ + T WTA+ + S+ A+ ++ GD +Y V
Sbjct: 616 GHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSI-SRDAVGVCLL-GDKLYAV 667
Score = 52.4 bits (124), Expect = 9e-07
Identities = 103/458 (22%), Positives = 163/458 (35%), Gaps = 75/458 (16%)
Query: 14 GGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATLQVLRGDRPALA 73
G + A R +L +F +F + +RE R E+++ + + +Q R L
Sbjct: 181 GDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELK 240
Query: 74 AEDELLQAVECAAFLQ----APALARFLEHNLTSDNCALL---CDAAAAFGLRDVFHSAA 126
ED + + A LQ A +FL L NC + DA L V H+
Sbjct: 241 -EDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYT 299
Query: 127 L-----------FICDGERELAAELA-----LPEARAYVAALRP--------------SS 156
+ F+ E+A LA +P + AL
Sbjct: 300 MEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKL 359
Query: 157 YAAVSTHTPAPGFLEDASRTLCYLDEEEDAWRTLAALPL----EASTLLAGVATLGNK-- 210
A + AP FL D + + D+ E + A+ E +L T K
Sbjct: 360 LAYIRLPLLAPQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKST 419
Query: 211 ---LYIVGGV---RGASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIG 264
L+ VGG+ +GA+ +E YD W + + R +A D +LY +G
Sbjct: 420 VGTLFAVGGMDSTKGATS--IEK---YDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVG 474
Query: 265 GEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVC----LWRPADTTAV 320
G +++VE Y+P WS + + G+ A G ++ W +T V
Sbjct: 475 GRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNT--V 532
Query: 321 VEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRNGPSDDFLHCAIDCLNLATGQWT 380
+ + W VA + P+S V LY V L +++C + T +WT
Sbjct: 533 ERWDPQARQWNFVATMSTPRSTVGVAVL-SGKLYAVGGRDGSSCLK-SVECFDPHTNKWT 590
Query: 381 ALPGQFVNSKGALFTAVVRGDTVYTVNRMFTLLYAIEG 418
L Q +G + G LLYAI G
Sbjct: 591 -LCAQMSKRRGGVGVTTWNG-----------LLYAIGG 616
Score = 44.3 bits (103), Expect = 2e-04
Identities = 33/99 (33%), Positives = 42/99 (42%), Gaps = 4/99 (4%)
Query: 203 GVATLGNKLYIVGGVRG-ASKEVVELGFC---YDPDGGTWHEFPSPHQPRYDTALAGFDG 258
GV T LY +GG AS L C YDP W S R +
Sbjct: 603 GVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGD 662
Query: 259 RLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAG 297
+LYA+GG + +++VE YDP W+ VA L AG
Sbjct: 663 KLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAG 701
Score = 37.7 bits (86), Expect = 0.022
Identities = 27/83 (32%), Positives = 35/83 (42%), Gaps = 6/83 (7%)
Query: 157 YAAVSTHTPAPGFLEDASRTLCYLDEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGG 216
YA PA S + D + D W +A++ + + GV LG+KLY VGG
Sbjct: 612 YAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAV--GVCLLGDKLYAVGG 669
Query: 217 VRG-ASKEVVELGFCYDPDGGTW 238
G A VE YDP W
Sbjct: 670 YDGQAYLNTVE---AYDPQTNEW 689
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 80.1 bits (196), Expect = 4e-15
Identities = 66/234 (28%), Positives = 109/234 (46%), Gaps = 16/234 (6%)
Query: 181 DEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGASK-EVVELGFCYDPDGGTWH 239
D + W +A + L GVA L +KLY+VGG G VE CY+P TW
Sbjct: 427 DLRTNMWTPVANM--NGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVE---CYNPKTKTWS 481
Query: 240 EFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVP 299
P R+ +A +G +YA+GG + +++VER+DP A W+FVA + P + V
Sbjct: 482 VMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVG 541
Query: 300 CAQACGRLFVCLWRPADT--TAVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVV- 356
A G+L+ R + +V + T+ W A++ + + G + LY +
Sbjct: 542 VAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRG-GVGVTTWNGLLYAIG 600
Query: 357 -RNGPSDDFLHCAIDCL---NLATGQWTALPGQFVNSKGALFTAVVRGDTVYTV 406
+ P+ + DC+ + T WTA+ + S+ A+ ++ GD +Y V
Sbjct: 601 GHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSI-SRDAVGVCLL-GDKLYAV 652
Score = 50.1 bits (118), Expect = 4e-06
Identities = 101/450 (22%), Positives = 160/450 (35%), Gaps = 75/450 (16%)
Query: 22 RALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATLQVLRGDRPALAAEDELLQA 81
R +L +F +F + +RE R E+++ + + +Q R L ED +
Sbjct: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELK-EDNIECL 232
Query: 82 VECAAFLQ----APALARFLEHNLTSDNCALL---CDAAAAFGLRDVFHSAAL------- 127
+ A LQ A +FL L NC + DA L V H+ +
Sbjct: 233 LSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVI 292
Query: 128 ----FICDGERELAAELA-----LPEARAYVAALRP--------------SSYAAVSTHT 164
F+ E+A LA +P + AL A +
Sbjct: 293 RNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPL 352
Query: 165 PAPGFLEDASRTLCYLDEEEDAWRTLAALPL----EASTLLAGVATLGNK-----LYIVG 215
AP FL D + + D+ E + A+ E +L T K L+ VG
Sbjct: 353 LAPQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVG 412
Query: 216 GV---RGASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPI 272
G+ +GA+ +E YD W + + R +A D +LY +GG +
Sbjct: 413 GMDSTKGATS--IEK---YDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTL 467
Query: 273 SSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVC----LWRPADTTAVVEYAVRTD 328
++VE Y+P WS + + G+ A G ++ W +T V + +
Sbjct: 468 NTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNT--VERWDPQAR 525
Query: 329 AWLPVAELRRPQSYGHCMVAHRDSLYVVRNGPSDDFLHCAIDCLNLATGQWTALPGQFVN 388
W VA + P+S V LY V L +++C + T +WT L Q
Sbjct: 526 QWNFVATMSTPRSTVGVAVL-SGKLYAVGGRDGSSCLK-SVECFDPHTNKWT-LCAQMSK 582
Query: 389 SKGALFTAVVRGDTVYTVNRMFTLLYAIEG 418
+G + G LLYAI G
Sbjct: 583 RRGGVGVTTWNG-----------LLYAIGG 601
Score = 44.3 bits (103), Expect = 2e-04
Identities = 33/99 (33%), Positives = 42/99 (42%), Gaps = 4/99 (4%)
Query: 203 GVATLGNKLYIVGGVRG-ASKEVVELGFC---YDPDGGTWHEFPSPHQPRYDTALAGFDG 258
GV T LY +GG AS L C YDP W S R +
Sbjct: 588 GVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGD 647
Query: 259 RLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAG 297
+LYA+GG + +++VE YDP W+ VA L AG
Sbjct: 648 KLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAG 686
Score = 37.7 bits (86), Expect = 0.022
Identities = 27/83 (32%), Positives = 35/83 (42%), Gaps = 6/83 (7%)
Query: 157 YAAVSTHTPAPGFLEDASRTLCYLDEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGG 216
YA PA S + D + D W +A++ + + GV LG+KLY VGG
Sbjct: 597 YAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAV--GVCLLGDKLYAVGG 654
Query: 217 VRG-ASKEVVELGFCYDPDGGTW 238
G A VE YDP W
Sbjct: 655 YDGQAYLNTVE---AYDPQTNEW 674
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 80.1 bits (196), Expect = 4e-15
Identities = 66/234 (28%), Positives = 109/234 (46%), Gaps = 16/234 (6%)
Query: 181 DEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGASK-EVVELGFCYDPDGGTWH 239
D + W +A + L GVA L +KLY+VGG G VE CY+P TW
Sbjct: 488 DLRTNMWTPVANM--NGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVE---CYNPKTKTWS 542
Query: 240 EFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVP 299
P R+ +A +G +YA+GG + +++VER+DP A W+FVA + P + V
Sbjct: 543 VMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVG 602
Query: 300 CAQACGRLFVCLWRPADT--TAVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVV- 356
A G+L+ R + +V + T+ W A++ + + G + LY +
Sbjct: 603 VAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRG-GVGVTTWNGLLYAIG 661
Query: 357 -RNGPSDDFLHCAIDCL---NLATGQWTALPGQFVNSKGALFTAVVRGDTVYTV 406
+ P+ + DC+ + T WTA+ + S+ A+ ++ GD +Y V
Sbjct: 662 GHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSI-SRDAVGVCLL-GDKLYAV 713
Score = 52.4 bits (124), Expect = 9e-07
Identities = 103/458 (22%), Positives = 163/458 (35%), Gaps = 75/458 (16%)
Query: 14 GGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATLQVLRGDRPALA 73
G + A R +L +F +F + +RE R E+++ + + +Q R L
Sbjct: 227 GDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELK 286
Query: 74 AEDELLQAVECAAFLQ----APALARFLEHNLTSDNCALL---CDAAAAFGLRDVFHSAA 126
ED + + A LQ A +FL L NC + DA L V H+
Sbjct: 287 -EDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYT 345
Query: 127 L-----------FICDGERELAAELA-----LPEARAYVAALRP--------------SS 156
+ F+ E+A LA +P + AL
Sbjct: 346 MEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKL 405
Query: 157 YAAVSTHTPAPGFLEDASRTLCYLDEEEDAWRTLAALPL----EASTLLAGVATLGNK-- 210
A + AP FL D + + D+ E + A+ E +L T K
Sbjct: 406 LAYIRLPLLAPQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKST 465
Query: 211 ---LYIVGGV---RGASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIG 264
L+ VGG+ +GA+ +E YD W + + R +A D +LY +G
Sbjct: 466 VGTLFAVGGMDSTKGATS--IEK---YDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVG 520
Query: 265 GEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVC----LWRPADTTAV 320
G +++VE Y+P WS + + G+ A G ++ W +T V
Sbjct: 521 GRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNT--V 578
Query: 321 VEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRNGPSDDFLHCAIDCLNLATGQWT 380
+ + W VA + P+S V LY V L +++C + T +WT
Sbjct: 579 ERWDPQARQWNFVATMSTPRSTVGVAVL-SGKLYAVGGRDGSSCLK-SVECFDPHTNKWT 636
Query: 381 ALPGQFVNSKGALFTAVVRGDTVYTVNRMFTLLYAIEG 418
L Q +G + G LLYAI G
Sbjct: 637 -LCAQMSKRRGGVGVTTWNG-----------LLYAIGG 662
Score = 44.3 bits (103), Expect = 2e-04
Identities = 33/99 (33%), Positives = 42/99 (42%), Gaps = 4/99 (4%)
Query: 203 GVATLGNKLYIVGGVRG-ASKEVVELGFC---YDPDGGTWHEFPSPHQPRYDTALAGFDG 258
GV T LY +GG AS L C YDP W S R +
Sbjct: 649 GVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGD 708
Query: 259 RLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAG 297
+LYA+GG + +++VE YDP W+ VA L AG
Sbjct: 709 KLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAG 747
Score = 37.7 bits (86), Expect = 0.022
Identities = 27/83 (32%), Positives = 35/83 (42%), Gaps = 6/83 (7%)
Query: 157 YAAVSTHTPAPGFLEDASRTLCYLDEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGG 216
YA PA S + D + D W +A++ + + GV LG+KLY VGG
Sbjct: 658 YAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAV--GVCLLGDKLYAVGG 715
Query: 217 VRG-ASKEVVELGFCYDPDGGTW 238
G A VE YDP W
Sbjct: 716 YDGQAYLNTVE---AYDPQTNEW 735
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 77.8 bits (190), Expect = 2e-14
Identities = 57/205 (27%), Positives = 89/205 (43%), Gaps = 8/205 (3%)
Query: 177 LCYLDEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGASKEVVELGFCYDPDGG 236
L Y +E+ W ++A P+ LAG TLG+ +Y+ GG G+ + YDP+
Sbjct: 349 LDYTADEDGVWYSVA--PMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMER--YDPNID 404
Query: 237 TWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAA 296
W R L G +Y +GG ++SVE+YDP G W+ V + +
Sbjct: 405 QWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRS 464
Query: 297 GVPCAQACGRLFVC--LWRPADTTAVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLY 354
G A ++V A ++V Y +RTD+W V + P+ Y V R LY
Sbjct: 465 GAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVL-RGRLY 523
Query: 355 VVRNGPSDDFLHCAIDCLNLATGQW 379
+ G + L +I+C + W
Sbjct: 524 AIA-GYDGNSLLSSIECYDPIIDSW 547
Score = 49.3 bits (116), Expect = 7e-06
Identities = 34/99 (34%), Positives = 44/99 (44%), Gaps = 4/99 (4%)
Query: 194 PLEASTLLAGVATLGNKLYIVGGVRG-ASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTA 252
P+ AGVA L + +Y+VGG G A VE Y+ +W S PR
Sbjct: 458 PMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVE---AYNIRTDSWTTVTSMTTPRCYVG 514
Query: 253 LAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADL 291
GRLYAI G + +SS+E YDP W V +
Sbjct: 515 ATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSM 553
Score = 45.4 bits (106), Expect = 1e-04
Identities = 101/465 (21%), Positives = 154/465 (33%), Gaps = 105/465 (22%)
Query: 18 FQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATLQVLRGDRPALAAED- 76
F A R +L +F +F S + E V + L+A L + + + E+
Sbjct: 44 FPAHRIVLAACSDYFCAMFTSELSEKGKPYVDIQGLTASTMEILLDFVYTETVHVTVENV 103
Query: 77 -ELLQAVECAAFLQA--PALARFLEHNLTSDNCALLCDAAAAFGLRDVFHSAALF----- 128
ELL A C L+ A FLE L NC + D A D+ +A +F
Sbjct: 104 QELLPAA-CLLQLKGVKQACCEFLESQLDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHF 162
Query: 129 -----------ICDGERELAAEL----ALPEARAYVAALRPSSYAAVSTHTPAPGFLEDA 173
+ GE E + E + A + +A P L+
Sbjct: 163 PEVVQHEEFILLSQGEVEKLIKCDEIQVDSEEPVFEAVINWVKHAKKEREESLPNLLQYV 222
Query: 174 SRTLC---YLDEEEDAWRTLAA---------------LPLEASTLLAGVAT---LG-NKL 211
L Y+ + DA + L E + + G T LG N++
Sbjct: 223 RMPLLTPRYITDVIDAEPFIRCSLQCRDLVDEAKKFHLRPELRSQMQGPRTRARLGANEV 282
Query: 212 YIVGGVRGASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTP 271
+V G G+ + +++ YDP W PS + R A R+Y IGG R+
Sbjct: 283 LLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSR 342
Query: 272 ISSV--------------------------------------------------ERYDPA 281
+SSV ERYDP
Sbjct: 343 LSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPN 402
Query: 282 AGCWSFVADLPQPAAGVPCAQACGRLFVCLWRPAD---TTAVVEYAVRTDAWLPVAELRR 338
WS + D+ G A G ++ CL +V +Y T W V +
Sbjct: 403 IDQWSMLGDMQTAREGAGLVVASGVIY-CLGGYDGLNILNSVEKYDPHTGHWTNVTPMAT 461
Query: 339 PQSYGHCMVAHRDSLYVVRNGPSDDFLH-CAIDCLNLATGQWTAL 382
+S G + D +YVV G D H +++ N+ T WT +
Sbjct: 462 KRS-GAGVALLNDHIYVV--GGFDGTAHLSSVEAYNIRTDSWTTV 503
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 76.6 bits (187), Expect = 4e-14
Identities = 50/129 (38%), Positives = 62/129 (48%), Gaps = 6/129 (4%)
Query: 181 DEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRG-ASKEVVELGFCYDPDGGTWH 239
D E D W T+A P+ G L N +Y VGG G AS VE YDP W
Sbjct: 434 DIESDQWSTVA--PMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVER---YDPHLDKWI 488
Query: 240 EFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVP 299
E Q R ++ G LY +GG +P+SSVERYDP + W +VA L P GV
Sbjct: 489 EVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVG 548
Query: 300 CAQACGRLF 308
A G++F
Sbjct: 549 IATVMGKIF 557
Score = 60.5 bits (145), Expect = 3e-09
Identities = 55/200 (27%), Positives = 86/200 (43%), Gaps = 7/200 (3%)
Query: 203 GVATLGNKLYIVGGVRGASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRLYA 262
GV ++ K+Y VGG G E + +DP W S + R ALA G +YA
Sbjct: 360 GVISVEGKVYAVGGHDG--NEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYA 417
Query: 263 IGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVCLWRP--ADTTAV 320
IGG T + VERYD + WS VA + P GV ++ A ++V
Sbjct: 418 IGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSV 477
Query: 321 VEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRNGPSDDFLHCAIDCLNLATGQWT 380
Y D W+ V E+ + ++ G+ + LYVV G D+ +++ + + +W
Sbjct: 478 ERYDPHLDKWIEVKEMGQRRA-GNGVSKLHGCLYVV-GGFDDNSPLSSVERYDPRSNKWD 535
Query: 381 ALPGQFVNSKGALFTAVVRG 400
+ +G + A V G
Sbjct: 536 YV-AALTTPRGGVGIATVMG 554
Score = 55.1 bits (131), Expect = 1e-07
Identities = 39/148 (26%), Positives = 63/148 (42%), Gaps = 4/148 (2%)
Query: 211 LYIVGGVRGASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRT 270
L+ VGG RG S + CY + +W P + R + +G++YA+GG
Sbjct: 320 LFCVGG-RGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNE 378
Query: 271 PISSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVCLWRPADT--TAVVEYAVRTD 328
+ S+E +DP W A + G+ A G ++ +T V Y + +D
Sbjct: 379 HLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESD 438
Query: 329 AWLPVAELRRPQSYGHCMVAHRDSLYVV 356
W VA + P+ G VA + +Y V
Sbjct: 439 QWSTVAPMNTPRG-GVGSVALVNHVYAV 465
Score = 47.4 bits (111), Expect = 3e-05
Identities = 31/100 (31%), Positives = 44/100 (44%), Gaps = 4/100 (4%)
Query: 203 GVATLGNKLYIVGGVRGASK-EVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRLY 261
GV+ L LY+VGG S VE YDP W + PR +A G+++
Sbjct: 501 GVSKLHGCLYVVGGFDDNSPLSSVER---YDPRSNKWDYVAALTTPRGGVGIATVMGKIF 557
Query: 262 AIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCA 301
A+GG +++VE +DP W V + AG A
Sbjct: 558 AVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVA 597
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 75.5 bits (184), Expect = 9e-14
Identities = 64/229 (27%), Positives = 101/229 (44%), Gaps = 12/229 (5%)
Query: 175 RTLCYLDEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGASKEVVELGFCYDPD 234
RT+ D +D W ++A++ STL G A L + LY VGG G++ + Y +
Sbjct: 362 RTVDVYDGVKDQWTSIASMQERRSTL--GAAVLNDLLYAVGGFDGSTGLASVEAYSYKTN 419
Query: 235 GGTWHEFPSPHQPRYDTALAGFDGRLYAIGG--EFQRTPISSVERYDPAAGCWSFVADLP 292
W + R + +G+LYA+GG R +S+VE+Y+PA W +VAD+
Sbjct: 420 --EWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMS 477
Query: 293 QPAAGVPCAQACGRLFVCLWR--PADTTAVVEYAVRTDAWLPVAELRR-PQSYGHCMVAH 349
+G G+L+ P +V Y T+ W VA++ ++ G C V
Sbjct: 478 TRRSGAGVGVLSGQLYATGGHDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAV-- 535
Query: 350 RDSLYVVRNGPSDDFLHCAIDCLNLATGQWTALPGQFVNSKGALFTAVV 398
LYVV G +++ N T +WT LP + AV+
Sbjct: 536 NGLLYVV-GGDDGSCNLASVEYYNPVTDKWTLLPTNMSTGRSYAGVAVI 583
Score = 60.1 bits (144), Expect = 4e-09
Identities = 51/174 (29%), Positives = 73/174 (41%), Gaps = 21/174 (12%)
Query: 178 CYLDEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGASKEVVELGFCYDPDGGT 237
CY D EED W +A LP + AGV + +Y VGG G+ + V YD
Sbjct: 319 CY-DFEEDRWDQIAELP--SRRCRAGVVFMAGHVYAVGGFNGSLR--VRTVDVYDGVKDQ 373
Query: 238 WHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAG 297
W S + R A + LYA+GG T ++SVE Y W FVA + +
Sbjct: 374 WTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSS 433
Query: 298 VPCAQACGRLFV----------CLWRPADTTAVVEYAVRTDAWLPVAELRRPQS 341
V G+L+ CL + V +Y T+ W+ VA++ +S
Sbjct: 434 VGVGVVEGKLYAVGGYDGASRQCL------STVEQYNPATNEWIYVADMSTRRS 481
Score = 56.6 bits (135), Expect = 5e-08
Identities = 45/160 (28%), Positives = 60/160 (37%), Gaps = 3/160 (1%)
Query: 194 PLEASTLLAGVATLGNKLYIVGGVRGASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTAL 253
P+ GV + KLY VGG GAS++ + Y+P W R +
Sbjct: 426 PMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGV 485
Query: 254 AGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVCLW- 312
G+LYA GG SVE YDP W VAD+ G L+V
Sbjct: 486 GVLSGQLYATGGHDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGD 545
Query: 313 -RPADTTAVVEYAVRTDAW-LPVAELRRPQSYGHCMVAHR 350
+ +V Y TD W L + +SY V H+
Sbjct: 546 DGSCNLASVEYYNPVTDKWTLLPTNMSTGRSYAGVAVIHK 585
Score = 43.1 bits (100), Expect = 5e-04
Identities = 61/255 (23%), Positives = 96/255 (37%), Gaps = 30/255 (11%)
Query: 193 LPLEASTLLAGVAT-------LGNKLYIVGGVRGASKEVVELGFCYDPDGGTWHEFPSPH 245
LPL+ L+ T L + +VGG + VE CYD + W +
Sbjct: 278 LPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVE---CYDFEEDRWDQIAELP 334
Query: 246 QPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQACG 305
R + G +YA+GG + +V+ YD W+ +A + + + + A
Sbjct: 335 SRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLND 394
Query: 306 RLFVCLWRPADT--TAVVEYAVRTDAWLPVAELR-RPQSYGHCMVAHRDSLYVV--RNGP 360
L+ T +V Y+ +T+ W VA + R S G +V LY V +G
Sbjct: 395 LLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVV--EGKLYAVGGYDGA 452
Query: 361 SDDFLHCAIDCLNLATGQWTALPGQFVNSKGALFTAVVRGDTVYTVNRMFTLLYAIEGGT 420
S L ++ N AT +W + GA V+ G LYA G
Sbjct: 453 SRQCL-STVEQYNPATNEWIYVADMSTRRSGA-GVGVLSGQ-----------LYATGGHD 499
Query: 421 WRLLREKAGFPRPGS 435
L+R+ PG+
Sbjct: 500 GPLVRKSVEVYDPGT 514
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 75.1 bits (183), Expect = 1e-13
Identities = 69/233 (29%), Positives = 99/233 (42%), Gaps = 10/233 (4%)
Query: 158 AAVSTHTPAPGFLEDAS--RTLCYLDEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVG 215
AAV A G + S T+ D + W+ ++ S L GVA L LY G
Sbjct: 385 AAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCL--GVAALHGLLYSAG 442
Query: 216 GVRGASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSV 275
G GAS + YDP GTW + R +A DG LYA+GG + +++V
Sbjct: 443 GYDGAS--CLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATV 500
Query: 276 ERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVCLWRPADT--TAVVEYAVRTDAWLPV 333
E+Y+P WS VA + + A G L+V + +V Y+ + AW V
Sbjct: 501 EKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESV 560
Query: 334 AELRRPQSYGHCMVAHRDSLYVVRNGPSDDFLHCAIDCLNLATGQWTALPGQF 386
A + +S H +VA LY V L+ +I+ N T +W A F
Sbjct: 561 APMNIRRS-THDLVAMDGWLYAVGGNDGSSSLN-SIEKYNPRTNKWVAASCMF 611
Score = 74.3 bits (181), Expect = 2e-13
Identities = 83/289 (28%), Positives = 125/289 (43%), Gaps = 23/289 (7%)
Query: 181 DEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGASK-EVVELGFCYDPDGGTWH 239
D D W +A++ + + GVA +GN+LY VGG G S VE YDP TW
Sbjct: 363 DTRTDRWHVVASMSTRRARV--GVAAVGNRLYAVGGYDGTSDLATVE---SYDPVTNTWQ 417
Query: 240 EFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVP 299
S R +A G LY+ GG + ++S ERYDP G W+ VA + V
Sbjct: 418 PEVSMGTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVR 477
Query: 300 CAQACGRLF-VCLWRPADTTAVVE-YAVRTDAWLPVAE-LRRPQSYGHCMVAHRDSLYVV 356
A G L+ V + + A VE Y + + W PVA L R S G ++ +LYV
Sbjct: 478 VATLDGNLYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVL--EGALYVA 535
Query: 357 RNGPSDDFLHCAIDCLNLATGQWTALPGQFVNSKGALFTAVVRGDTVYTV--NRMFTLLY 414
L+ +++ + G W ++ +N + + V +Y V N + L
Sbjct: 536 GGNDGTSCLN-SVERYSPKAGAWESVAP--MNIRRSTHDLVAMDGWLYAVGGNDGSSSLN 592
Query: 415 AIE---GGTWRLLREKAGFPRPGSLQTFLLRL----PPGAPGPVTSTTA 456
+IE T + + F R S+ +L L PP +P S+T+
Sbjct: 593 SIEKYNPRTNKWVAASCMFTRRSSVGVAVLELLNFPPPSSPTLSVSSTS 641
Score = 40.4 bits (93), Expect = 0.003
Identities = 22/74 (29%), Positives = 31/74 (41%), Gaps = 7/74 (9%)
Query: 231 YDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVAD 290
YD WH S R +A RLYA+GG + +++VE YDP W
Sbjct: 362 YDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTW----- 416
Query: 291 LPQPAAGVPCAQAC 304
QP + ++C
Sbjct: 417 --QPEVSMGTRRSC 428
>gi|55741643 kelch-like 14 [Homo sapiens]
Length = 628
Score = 75.1 bits (183), Expect = 1e-13
Identities = 66/278 (23%), Positives = 107/278 (38%), Gaps = 21/278 (7%)
Query: 174 SRTLCYLDEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGV---RGASKEVVELGFC 230
S + Y D+E+ W+ L +P ++ V + N L+++GG K
Sbjct: 339 SNLVQYYDDEKKTWKILTIMPYNSAHHC--VVEVENFLFVLGGEDQWNPNGKHSTNFVSR 396
Query: 231 YDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVAD 290
YDP +W + P + R D LY IGG + +SSVE Y+ W +V+
Sbjct: 397 YDPRFNSWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSS 456
Query: 291 LPQPAAGVPCAQACGRLFVC--LWRPADTTAVVEYAVRTDAWLPVAELRRPQSYGHCMVA 348
LPQP A A G++++ + + Y D W ++ ++ H +
Sbjct: 457 LPQPLAAHAGAVHNGKIYISGGVHNGEYVPWLYCYDPVMDVWARKQDMNTKRAI-HTLAV 515
Query: 349 HRDSLYVVRNGPSDDFLH---CAIDCLNLATGQWTALPGQFVNSKGALFTAVVRGDTVYT 405
D LY + F H ++C + QW L + + AV+ D++Y
Sbjct: 516 MNDRLYAIGGNHLKGFSHLDVMLVECYDPKGDQWNILQTPILEGRSGPGCAVL-DDSIYL 574
Query: 406 VN---------RMFTLLYAIEGGTWRLLREKAGFPRPG 434
V + T+ Y E GTW L P G
Sbjct: 575 VGGYSWSMGAYKSSTICYCPEKGTWTELEGDVAEPLAG 612
>gi|31542246 kelch-like 36 [Homo sapiens]
Length = 616
Score = 74.3 bits (181), Expect = 2e-13
Identities = 71/228 (31%), Positives = 96/228 (42%), Gaps = 29/228 (12%)
Query: 172 DASRTLCYLDEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGV---RGASKEVVELG 228
+ S CYLD + + W + PL A VA LG ++I GG L
Sbjct: 310 ELSDDTCYLDAKSEQW--VKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLL 367
Query: 229 FCYDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFV 288
+ YDP W + S +Q R D LA + L AIGG + +SSVE Y P WS+V
Sbjct: 368 YRYDPRCKQWIKVASMNQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYV 427
Query: 289 ADLPQPAAGVPCAQACGRLFVCLWRPAD------TTAVVEYAVRTDAWLPVAELRRPQSY 342
A LP+ G A + FV + D ++ Y RTD W E RRP +
Sbjct: 428 AGLPRFTYG--HAGTIYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVW----EERRPMTT 481
Query: 343 G---HCMVAHRDSLYVVRNGPSDD-------FLHCAIDCLNLATGQWT 380
H M + DS+Y + G SDD F ++ + QWT
Sbjct: 482 ARGWHSMCSLGDSIYSI--GGSDDNIESMERFDVLGVEAYSPQCNQWT 527
Score = 45.8 bits (107), Expect = 8e-05
Identities = 38/144 (26%), Positives = 59/144 (40%), Gaps = 16/144 (11%)
Query: 177 LCYLDEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGASKEVVELGF----CYD 232
LCY D D W P+ + + +LG+ +Y +GG + + Y
Sbjct: 464 LCY-DHRTDVWEERR--PMTTARGWHSMCSLGDSIYSIGGSDDNIESMERFDVLGVEAYS 520
Query: 233 PDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGG-EFQRTPIS-SVERYDPAAGCWSFVAD 290
P W ++ +A ++GR+Y +GG ++ T S +V+ YD A WS D
Sbjct: 521 PQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWENTAFSKTVQVYDREADKWSRGVD 580
Query: 291 LPQPAAGVPCAQACGRLFVCLWRP 314
LP+ AG G VC P
Sbjct: 581 LPKAIAG-------GSACVCALEP 597
>gi|24475847 influenza virus NS1A binding protein [Homo sapiens]
Length = 642
Score = 72.4 bits (176), Expect = 8e-13
Identities = 63/245 (25%), Positives = 104/245 (42%), Gaps = 11/245 (4%)
Query: 138 AELALPEARAYVAALRPSSYAAVSTHTPAPGFLEDASRTLCYLDEEEDAWRTLAALPLEA 197
A + P AR +A L Y ++ G +D S Y D D W + L
Sbjct: 399 APMRTPRARFQMAVLMGQLYVVGGSN----GHSDDLSCGEMY-DSNIDDW--IPVPELRT 451
Query: 198 STLLAGVATLGNKLYIVGGVRGASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFD 257
+ AGV L KLYIVGG ++ ++ +DP W + R+ +A+
Sbjct: 452 NRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELG 511
Query: 258 GRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVCLWRPAD- 316
G LY IGG +++VERY+P W+ +A + G A G+LFVC
Sbjct: 512 GYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSH 571
Query: 317 -TTAVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRNGPSDDFLHCAIDCLNLA 375
+ V Y + W + + P+S + +++Y V ++FL+ ++ NL
Sbjct: 572 AISCVEMYDPTRNEWKMMGNMTSPRSNAG-IATVGNTIYAVGGFDGNEFLN-TVEVYNLE 629
Query: 376 TGQWT 380
+ +W+
Sbjct: 630 SNEWS 634
Score = 47.8 bits (112), Expect = 2e-05
Identities = 46/147 (31%), Positives = 65/147 (44%), Gaps = 12/147 (8%)
Query: 243 SPHQ-PRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCA 301
SP Q R A +G+L A GG + + +VE Y+P WSF+A + P A A
Sbjct: 352 SPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMA 411
Query: 302 QACGRLFV---CLWRPADTTAVVEYAVRTDAWLPVAELRRPQ-SYGHCMVAHRDSLYVVR 357
G+L+V D + Y D W+PV ELR + + G C A LY+V
Sbjct: 412 VLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVC--ALNGKLYIV- 468
Query: 358 NGPSDDFLHCAI---DCLNLATGQWTA 381
G SD + + D + T WT+
Sbjct: 469 -GGSDPYGQKGLKNCDVFDPVTKLWTS 494
Score = 37.7 bits (86), Expect = 0.022
Identities = 29/117 (24%), Positives = 45/117 (38%), Gaps = 3/117 (2%)
Query: 194 PLEASTLLAGVATLGNKLYIVGGVRGASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTAL 253
P++ + G A + KL GG +E + CY+P W PR +
Sbjct: 353 PMQYARSGLGTAEMNGKLIAAGGYN--REECLRTVECYNPHTDHWSFLAPMRTPRARFQM 410
Query: 254 AGFDGRLYAIGGEFQRT-PISSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFV 309
A G+LY +GG + +S E YD W V +L G+L++
Sbjct: 411 AVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYI 467
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 70.5 bits (171), Expect = 3e-12
Identities = 60/238 (25%), Positives = 105/238 (44%), Gaps = 13/238 (5%)
Query: 142 LPEARAYVAALRPSSYAAVSTHTPAPGFLE--DASRTLCYLDEEEDAWRTLAALPLEAST 199
LPE R+ + + R + A G ++ + T+ D ++W + +
Sbjct: 409 LPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTM--NGRR 466
Query: 200 LLAGVATLGNKLYIVGGVRGASK-EVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDG 258
L GVA + NKLY+VGG G VE C++P G W P R+ +A +G
Sbjct: 467 LQFGVAVIDNKLYVVGGRDGLKTLNTVE---CFNPVGKIWTVMPPMSTHRHGLGVATLEG 523
Query: 259 RLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVCLWRPADT- 317
+YA+GG + +++VER+DP W++VA + P + V +L+ R +
Sbjct: 524 PMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSC 583
Query: 318 -TAVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRNGPSDDFLHCA--IDCL 372
++ + T+ W A + + + G + + LYVV + HC+ DC+
Sbjct: 584 LKSMEYFDPHTNKWSLCAPMSKRRG-GVGVATYNGFLYVVGGHDAPASNHCSRLSDCV 640
Score = 67.8 bits (164), Expect = 2e-11
Identities = 56/187 (29%), Positives = 82/187 (43%), Gaps = 16/187 (8%)
Query: 203 GVATLGNKLYIVGGVRGASK-EVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRLY 261
GVATL +Y VGG G S VE +DP+G W+ S PR + + +LY
Sbjct: 517 GVATLEGPMYAVGGHDGWSYLNTVER---WDPEGRQWNYVASMSTPRSTVGVVALNNKLY 573
Query: 262 AIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVCLWRPADTT--- 318
AIGG + + S+E +DP WS A + + GV A G L+V A +
Sbjct: 574 AIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHC 633
Query: 319 -----AVVEYAVRTDAWLPVAELRRPQ-SYGHCMVAHRDSLYVVRNGPSDDFLHCAIDCL 372
V Y + D+W VA L P+ + C + D LYVV +L+ ++
Sbjct: 634 SRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLG--DKLYVVGGYDGHTYLN-TVESY 690
Query: 373 NLATGQW 379
+ +W
Sbjct: 691 DAQRNEW 697
Score = 35.4 bits (80), Expect = 0.11
Identities = 31/106 (29%), Positives = 40/106 (37%), Gaps = 6/106 (5%)
Query: 136 LAAELALPEARAYVAALRPSSYAAVSTHTPAPGFLEDASRTLCYLDEEEDAWRTLAALPL 195
L A ++ VA Y PA S + D + D+W T+A PL
Sbjct: 599 LCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVA--PL 656
Query: 196 EASTLLAGVATLGNKLYIVGGVRGAS-KEVVELGFCYDPDGGTWHE 240
V LG+KLY+VGG G + VE YD W E
Sbjct: 657 SVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVE---SYDAQRNEWKE 699
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 70.5 bits (171), Expect = 3e-12
Identities = 60/238 (25%), Positives = 105/238 (44%), Gaps = 13/238 (5%)
Query: 142 LPEARAYVAALRPSSYAAVSTHTPAPGFLE--DASRTLCYLDEEEDAWRTLAALPLEAST 199
LPE R+ + + R + A G ++ + T+ D ++W + +
Sbjct: 409 LPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTM--NGRR 466
Query: 200 LLAGVATLGNKLYIVGGVRGASK-EVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDG 258
L GVA + NKLY+VGG G VE C++P G W P R+ +A +G
Sbjct: 467 LQFGVAVIDNKLYVVGGRDGLKTLNTVE---CFNPVGKIWTVMPPMSTHRHGLGVATLEG 523
Query: 259 RLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVCLWRPADT- 317
+YA+GG + +++VER+DP W++VA + P + V +L+ R +
Sbjct: 524 PMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSC 583
Query: 318 -TAVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRNGPSDDFLHCA--IDCL 372
++ + T+ W A + + + G + + LYVV + HC+ DC+
Sbjct: 584 LKSMEYFDPHTNKWSLCAPMSKRRG-GVGVATYNGFLYVVGGHDAPASNHCSRLSDCV 640
Score = 67.8 bits (164), Expect = 2e-11
Identities = 56/187 (29%), Positives = 82/187 (43%), Gaps = 16/187 (8%)
Query: 203 GVATLGNKLYIVGGVRGASK-EVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRLY 261
GVATL +Y VGG G S VE +DP+G W+ S PR + + +LY
Sbjct: 517 GVATLEGPMYAVGGHDGWSYLNTVER---WDPEGRQWNYVASMSTPRSTVGVVALNNKLY 573
Query: 262 AIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVCLWRPADTT--- 318
AIGG + + S+E +DP WS A + + GV A G L+V A +
Sbjct: 574 AIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHC 633
Query: 319 -----AVVEYAVRTDAWLPVAELRRPQ-SYGHCMVAHRDSLYVVRNGPSDDFLHCAIDCL 372
V Y + D+W VA L P+ + C + D LYVV +L+ ++
Sbjct: 634 SRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLG--DKLYVVGGYDGHTYLN-TVESY 690
Query: 373 NLATGQW 379
+ +W
Sbjct: 691 DAQRNEW 697
Score = 35.4 bits (80), Expect = 0.11
Identities = 31/106 (29%), Positives = 40/106 (37%), Gaps = 6/106 (5%)
Query: 136 LAAELALPEARAYVAALRPSSYAAVSTHTPAPGFLEDASRTLCYLDEEEDAWRTLAALPL 195
L A ++ VA Y PA S + D + D+W T+A PL
Sbjct: 599 LCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVA--PL 656
Query: 196 EASTLLAGVATLGNKLYIVGGVRGAS-KEVVELGFCYDPDGGTWHE 240
V LG+KLY+VGG G + VE YD W E
Sbjct: 657 SVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVE---SYDAQRNEWKE 699
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 69.3 bits (168), Expect = 7e-12
Identities = 51/164 (31%), Positives = 72/164 (43%), Gaps = 7/164 (4%)
Query: 181 DEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGAS-KEVVELGFCYDPDGGTWH 239
D + + W + A P GVA LG LY VGG G S +VE YDP W
Sbjct: 386 DPKTNQWSSDVA-PTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVER---YDPKENKWT 441
Query: 240 EFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVP 299
S R A+A G LYA+GG +P+++VERY+P W +A + +
Sbjct: 442 RVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLG 501
Query: 300 CAQACGRLFVCLWRPADT--TAVVEYAVRTDAWLPVAELRRPQS 341
CA ++ R T ++ Y RT+ W PV + +S
Sbjct: 502 CAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRS 545
Score = 66.6 bits (161), Expect = 4e-11
Identities = 69/262 (26%), Positives = 111/262 (42%), Gaps = 18/262 (6%)
Query: 172 DASRTLCYLDEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGAS-KEVVELGFC 230
DA ++ D + + WR +A++ + GV+ L + LY VGG G+S VE
Sbjct: 330 DAISSVERYDPQTNEWRMVASMSKRRCGV--GVSVLDDLLYAVGGHDGSSYLNSVER--- 384
Query: 231 YDPDGGTWHEFPSPHQP-RYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVA 289
YDP W +P R +A G LYA+GG+ + ++ VERYDP W+ VA
Sbjct: 385 YDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVA 444
Query: 290 DLPQPAAGVPCAQACGRLFVCLWRPADT--TAVVEYAVRTDAWLPVAELRRPQSYGHCMV 347
+ GV A G L+ + V Y + + W +A + + + C V
Sbjct: 445 SMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAV 504
Query: 348 AHRDSLYVVRNGPSDDFLHCAIDCLNLATGQWTALPGQFVNSKGALFTAVVRGDTVY--- 404
++D +Y V G D + + N T QW+ + + + + AVV G +
Sbjct: 505 -YQDMIYAV-GGRDDTTELSSAERYNPRTNQWSPVVA-MTSRRSGVGLAVVNGQLMAVGG 561
Query: 405 ---TVNRMFTLLYAIEGGTWRL 423
T ++ + TWRL
Sbjct: 562 FDGTTYLKTIEVFDPDANTWRL 583
Score = 51.2 bits (121), Expect = 2e-06
Identities = 77/328 (23%), Positives = 113/328 (34%), Gaps = 62/328 (18%)
Query: 13 VGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEV--------RLGVLSAGGFRATLQV 64
VG + A R +L +FR +F + E+R EV + +L + + + V
Sbjct: 74 VGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITV 133
Query: 65 LRGDRPALAAEDELLQAVECAAFLQAPALARFLEHNLTSDNCALLCDAAAAFGLRDVFHS 124
G+ L LLQ E A FL+ L NC + A R++
Sbjct: 134 EEGNVQTLLPAACLLQLAEIQE-----ACCEFLKRQLDPSNCLGIRAFADTHSCRELLRI 188
Query: 125 AALFICDGERELAAE---LALP-----------------EARAYVAALRPSSYAAVSTHT 164
A F +E+ + LP E + + A + Y+
Sbjct: 189 ADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRP 248
Query: 165 PAPGFLEDA---------------SRTLCYLDEE----EDAWRTLAALPLEASTLLAGVA 205
P L+ S L DEE D + LP E L+ G
Sbjct: 249 QLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNYLLLPQERP-LMQGPR 307
Query: 206 T-------LGNKLYIVGGVRGASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDG 258
T G L+ VGG S + + YDP W S + R ++ D
Sbjct: 308 TRPRKPIRCGEVLFAVGG--WCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDD 365
Query: 259 RLYAIGGEFQRTPISSVERYDPAAGCWS 286
LYA+GG + ++SVERYDP WS
Sbjct: 366 LLYAVGGHDGSSYLNSVERYDPKTNQWS 393
Score = 37.4 bits (85), Expect = 0.029
Identities = 18/39 (46%), Positives = 22/39 (56%)
Query: 260 LYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGV 298
L+A+GG ISSVERYDP W VA + + GV
Sbjct: 320 LFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGV 358
>gi|158508542 kelch-like 33 [Homo sapiens]
Length = 453
Score = 66.2 bits (160), Expect = 6e-11
Identities = 74/276 (26%), Positives = 106/276 (38%), Gaps = 28/276 (10%)
Query: 187 WRTLAALPLEASTLLAGVATLGNKLYIVGGVRGAS-KEVVELGFCYDPDGGTWHEFPSPH 245
W L ALP + G++LY+ GG S + ++P W E
Sbjct: 170 WGQLPALPAPGRFRHGAASLAGSELYVCGGQDFYSHSNTLASTLRWEPSQEDWEEMAPLS 229
Query: 246 QPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPC-AQAC 304
Q R +L DG+LYA+GG + SVE Y+P W P PA PC A A
Sbjct: 230 QARSLFSLVALDGKLYALGGRHNDVALDSVETYNPELNVWR-----PAPALPAPCFAHAA 284
Query: 305 GRLFVCLWRPADTTAVVEYAVRTDAWLPVAELRRPQSY---------GHCMVAHRDSLYV 355
L L+ +Y + P +L +P ++ GH M A LYV
Sbjct: 285 AILEGQLYVSGGCGGTGQYLASLMHYDP--KLEKPGTFLSPMGVPRAGHVMAALGGRLYV 342
Query: 356 VRN-GPSDDFLHCAIDCLNLATGQWT---ALPGQFVNSKGALFTA--VVRGDTVYTVNRM 409
G ++D L + + L T WT LP V + A+ +V G + +
Sbjct: 343 AGGLGETEDLL--SFEAYELRTDSWTHLAPLPSPHVGAASAVLQGELLVLGGYSHRTYAL 400
Query: 410 FTLLYAIEGGTWRLLREKAGFPRP-GSLQTFLLRLP 444
L++A G R L PRP + +L LP
Sbjct: 401 SHLIHAYCPGLGRWLC-LGTLPRPRAEMPACILTLP 435
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 65.5 bits (158), Expect = 1e-10
Identities = 64/250 (25%), Positives = 110/250 (44%), Gaps = 18/250 (7%)
Query: 142 LPEARAYVAALRPSSYAAVSTHTPAPGFLED--ASRTLCYLDEEEDAWRTLAALPLEAST 199
LPE R + + R + A G +++ + T+ D + W + A +
Sbjct: 439 LPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATTIEKYDLRTNLW--IQAGMMNGRR 496
Query: 200 LLAGVATLGNKLYIVGGVRGASK-EVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDG 258
L GVA + +KL+++GG G VE CY+P TW P R+ + +G
Sbjct: 497 LQFGVAVIDDKLFVIGGRDGLKTLNTVE---CYNPKTKTWTVLPPMSTHRHGLGVTVLEG 553
Query: 259 RLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVCLWRPADT- 317
+YA+GG + +++VER+DP + W+FVA + + V A G+L+ R +
Sbjct: 554 PIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSC 613
Query: 318 -TAVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDS-LYVVRNGPSDDFLHCA-----ID 370
+++ Y T+ W A + + + G VA D LY V + HC+ ++
Sbjct: 614 LSSMEYYDPHTNKWNMCAPMCKRR--GGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVE 671
Query: 371 CLNLATGQWT 380
+ T WT
Sbjct: 672 RYDPKTDTWT 681
Score = 65.1 bits (157), Expect = 1e-10
Identities = 55/177 (31%), Positives = 77/177 (43%), Gaps = 17/177 (9%)
Query: 181 DEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGASKEVVELGFCYDPDGGTWHE 240
D + W +A++ + ST+ GVA L KLY VGG G+S + YDP W+
Sbjct: 574 DPQSQQWTFVASMSIARSTV--GVAALNGKLYSVGGRDGSS--CLSSMEYYDPHTNKWNM 629
Query: 241 FPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISS--------VERYDPAAGCWSFVADLP 292
+ R +A DG LYA+GG P S+ VERYDP W+ VA L
Sbjct: 630 CAPMCKRRGGVGVATCDGFLYAVGGH--DAPASNHCSRLLDYVERYDPKTDTWTMVAPLS 687
Query: 293 QPAAGVPCAQACGRLFVCLWRPADT--TAVVEYAVRTDAWLPVAELRRPQSYGHCMV 347
P V RL+ T + Y +T+ W +A L ++ G C+V
Sbjct: 688 MPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASLNIGRA-GACVV 743
Score = 49.7 bits (117), Expect = 6e-06
Identities = 36/123 (29%), Positives = 51/123 (41%), Gaps = 6/123 (4%)
Query: 179 YLDEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGG----VRGASKEVVELGFCYDPD 234
Y D + W A + + GVAT LY VGG +++ YDP
Sbjct: 619 YYDPHTNKWNMCAPMCKRRGGV--GVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPK 676
Query: 235 GGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQP 294
TW PR + RLYA+GG +T ++++E YDP W+ +A L
Sbjct: 677 TDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASLNIG 736
Query: 295 AAG 297
AG
Sbjct: 737 RAG 739
Score = 30.0 bits (66), Expect = 4.6
Identities = 24/90 (26%), Positives = 41/90 (45%), Gaps = 6/90 (6%)
Query: 318 TAVVEYAVRTDAWLPVAELR-RPQSYGHCMVAHRDSLYVVRNGPSDDFLHCAIDCLNLAT 376
T + +Y +RT+ W+ + R +G ++ D L+V+ L+ ++C N T
Sbjct: 474 TTIEKYDLRTNLWIQAGMMNGRRLQFGVAVID--DKLFVIGGRDGLKTLN-TVECYNPKT 530
Query: 377 GQWTALPGQFVNSKGALFTAVVRGDTVYTV 406
WT LP + G L V+ G +Y V
Sbjct: 531 KTWTVLPPMSTHRHG-LGVTVLEG-PIYAV 558
>gi|156616301 kelch-like 32 [Homo sapiens]
Length = 620
Score = 64.7 bits (156), Expect = 2e-10
Identities = 96/362 (26%), Positives = 138/362 (38%), Gaps = 70/362 (19%)
Query: 63 QVLRGDRPALAAEDELLQAVECAAFLQAPALARFLEHNLTSDNCALLCDAAAAFGLRDV- 121
+VL+ DR +E+++ Q R+LEHN L FGL DV
Sbjct: 192 EVLKSDRLTSLSEEQIWQLA-----------VRWLEHNCHYQYMDELLQYIR-FGLMDVD 239
Query: 122 -FHSAALFICDGERELAAELALPEARAYVAALRPSSYAAV--STHTPAPGFLEDA----- 173
H+ AL + A + EA Y S YA T P F D
Sbjct: 240 TLHTVALSHPLVQASETATALVNEALEY----HQSIYAQPVWQTRRTKPRFQSDTLYIIG 295
Query: 174 --SRTLCYLDE--------EEDA-------WRTLAALPLEASTLLAGVATLGNKLYIVGG 216
R +C + E +E+A W LA +P+ S VA +G+ L++ GG
Sbjct: 296 GKKREVCKVKELRYFNPVDQENALIAAIANWSELAPMPVGRSHHC--VAVMGDFLFVAGG 353
Query: 217 -VRGASKEV--VELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQ-RTPI 272
V AS V YDP +W E R L + LYA+GG + R +
Sbjct: 354 EVEHASGRTCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVL 413
Query: 273 SSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVC---LWRPADTTAVVEYAVR--- 326
+VERY P W+FV + + +C +V LW T +Y R
Sbjct: 414 PTVERYCPKKNKWTFVQSFDR-------SLSCHAGYVADGLLWISGGVTNTAQYQNRLMV 466
Query: 327 ----TDAWLPVAELRRPQSYGHCMVAHRDSLYVVRNGP----SDDFLHCAIDCLNLATGQ 378
+ W+ + + + + Y H M A + LYV+ +D L ID N+ T Q
Sbjct: 467 YEPNQNKWISRSPMLQRRVY-HSMAAVQRKLYVLGGNDLDYNNDRILVRHIDSYNIDTDQ 525
Query: 379 WT 380
WT
Sbjct: 526 WT 527
>gi|24432026 kelch-like [Homo sapiens]
Length = 634
Score = 63.9 bits (154), Expect = 3e-10
Identities = 51/190 (26%), Positives = 86/190 (45%), Gaps = 15/190 (7%)
Query: 203 GVATLGNKLYIVGG---VRGASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGR 259
G+A L N +Y++GG V+G E + YDP W + S Q D ++
Sbjct: 343 GIAVLNNFVYLIGGDNNVQGFRAE--SRCWRYDPRHNRWFQIQSLQQEHADLSVCVVGRY 400
Query: 260 LYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFV-CLWRPADTT 318
+YA+ G +++VERYDPA W++VA L + A G++++ C R D
Sbjct: 401 IYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKREVYAHAGATLEGKMYITCGRRGEDYL 460
Query: 319 AVVE-YAVRTDAWLPVAE--LRRPQSYGHCMVAHRDSLYVVRNGPSDDFLH---CAIDCL 372
Y ++ W +A+ +RR H M + LYV+ +D + C
Sbjct: 461 KETHCYDPGSNTWHTLADGPVRRA---WHGMATLLNKLYVIGGSNNDAGYRRDVHQVACY 517
Query: 373 NLATGQWTAL 382
+ +GQW+++
Sbjct: 518 SCTSGQWSSV 527
Score = 54.3 bits (129), Expect = 2e-07
Identities = 47/158 (29%), Positives = 63/158 (39%), Gaps = 12/158 (7%)
Query: 181 DEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGASKEVVELGFCYDPDGGTWHE 240
D ++W +A PL+ ATL K+YI G RG ++ ++ CYDP TWH
Sbjct: 420 DPATNSWAYVA--PLKREVYAHAGATLEGKMYITCGRRG--EDYLKETHCYDPGSNTWHT 475
Query: 241 FPSPHQPRYDTALAGFDGRLYAIGGEFQ----RTPISSVERYDPAAGCWSFVADLPQPAA 296
R +A +LY IGG R + V Y +G WS V LP
Sbjct: 476 LADGPVRRAWHGMATLLNKLYVIGGSNNDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHG 535
Query: 297 GVPCAQACGRLFVCLWRP----ADTTAVVEYAVRTDAW 330
A R++V R + T V Y V D W
Sbjct: 536 EPGIAVLDNRIYVLGGRSHNRGSRTGYVHIYDVEKDCW 573
Score = 51.6 bits (122), Expect = 1e-06
Identities = 94/413 (22%), Positives = 143/413 (34%), Gaps = 61/413 (14%)
Query: 13 VGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATLQVLRGDRPAL 72
V G+ +A R LL C +FRG+F G++E EV + +S L + L
Sbjct: 56 VEGRHIEAHRILLAASCDYFRGMFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELEL 115
Query: 73 AAEDELLQAVECAAFLQAPALARFL---------EHN---------------LTSDNCAL 108
+ + + + + A LQ P + F E N LT
Sbjct: 116 SLSN-VQETLVAACQLQIPEIIHFCCDFLMSWVDEENILDVYRLAELFDLSRLTEQLDTY 174
Query: 109 LCDAAAAFGLRDVFHSAAL-----FICDGERELAAELALPE-ARAYVAALRPSSYAAVST 162
+ AF D + L + E++ E + E A Y +L +S
Sbjct: 175 ILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLYHYSLEQVQADQISL 234
Query: 163 HTPAPGFLEDASRTLCYLDEEEDAWRTLAALPLE---ASTLL------------AGVATL 207
H P P LE L + + L PL AS L+ + L
Sbjct: 235 HEP-PKLLETVRFPLMEAEVLQRLHDKLDPSPLRDTVASALMYHRNESLQPSLQSPQTEL 293
Query: 208 GNKLYIV---GGVRGASKEVVELGFCY-DPDGGTWHEFPSPHQPRY-DTALAGFDGRLYA 262
+ V GG+ V+ Y +P G W F + PR + +A + +Y
Sbjct: 294 RSDFQCVVGFGGIHSTPSTVLSDQAKYLNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYL 353
Query: 263 IGGEFQRTPI---SSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVCLWRP--ADT 317
IGG+ S RYDP W + L Q A + ++ R D
Sbjct: 354 IGGDNNVQGFRAESRCWRYDPRHNRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDL 413
Query: 318 TAVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRNGPSDDFL---HC 367
AV Y T++W VA L+R + Y H +Y+ +D+L HC
Sbjct: 414 NAVERYDPATNSWAYVAPLKR-EVYAHAGATLEGKMYITCGRRGEDYLKETHC 465
Score = 33.1 bits (74), Expect = 0.54
Identities = 32/118 (27%), Positives = 52/118 (44%), Gaps = 17/118 (14%)
Query: 143 PEARAY--VAALRPSSYAAVSTHTPAPGFLEDASRTLCYLDEEEDAWRTLAALPLEASTL 200
P RA+ +A L Y ++ A G+ D + CY W ++ LP A
Sbjct: 480 PVRRAWHGMATLLNKLYVIGGSNNDA-GYRRDVHQVACY-SCTSGQWSSVCPLP--AGHG 535
Query: 201 LAGVATLGNKLYIVGG---VRGASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAG 255
G+A L N++Y++GG RG+ V + YD + W E P+ D +++G
Sbjct: 536 EPGIAVLDNRIYVLGGRSHNRGSRTGYVHI---YDVEKDCWEE-----GPQLDNSISG 585
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 63.2 bits (152), Expect = 5e-10
Identities = 54/206 (26%), Positives = 85/206 (41%), Gaps = 12/206 (5%)
Query: 138 AELALPEARAYVAALRPSSYAAVSTHTPAPGFLEDASRTLCYLDEEEDAWRTLAALPLEA 197
A +++P R V + YA +H G + S + + E D W +A P+
Sbjct: 407 APMSVPRNRIGVGVIDGHIYAVGGSH----GCIHHNS--VERYEPERDEWHLVA--PMLT 458
Query: 198 STLLAGVATLGNKLYIVGGVRGASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFD 257
+ GVA L LY VGG G ++ + CY P+ W + + R +
Sbjct: 459 RRIGVGVAVLNRLLYAVGGFDGTNR--LNSAECYYPERNEWRMITAMNTIRSGAGVCVLH 516
Query: 258 GRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVCLWRPADT 317
+YA GG + ++SVERYD W+FVA + + + GR++V T
Sbjct: 517 NCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHT 576
Query: 318 --TAVVEYAVRTDAWLPVAELRRPQS 341
+V Y TD W V + +S
Sbjct: 577 FLDSVECYDPDTDTWSEVTRMTSGRS 602
Score = 52.8 bits (125), Expect = 7e-07
Identities = 41/125 (32%), Positives = 53/125 (42%), Gaps = 7/125 (5%)
Query: 178 CYLDEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGASK-EVVELGFCYDPDGG 236
CY E + WR + A+ S AGV L N +Y GG G + VE YD +
Sbjct: 489 CYYPERNE-WRMITAMNTIRSG--AGVCVLHNCIYAAGGYDGQDQLNSVER---YDVETE 542
Query: 237 TWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAA 296
TW R + GR+Y +GG T + SVE YDP WS V + +
Sbjct: 543 TWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRS 602
Query: 297 GVPCA 301
GV A
Sbjct: 603 GVGVA 607
Score = 51.6 bits (122), Expect = 1e-06
Identities = 40/138 (28%), Positives = 55/138 (39%), Gaps = 4/138 (2%)
Query: 166 APGFLEDASRTLCYLDEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGASKEVV 225
A G+ + L + + W LA L + S L V +G LY VGG +
Sbjct: 331 AGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCV--VGGLLYAVGGRNNSPDGNT 388
Query: 226 ELGF--CYDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAG 283
+ CY+P W PR + DG +YA+GG +SVERY+P
Sbjct: 389 DSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERD 448
Query: 284 CWSFVADLPQPAAGVPCA 301
W VA + GV A
Sbjct: 449 EWHLVAPMLTRRIGVGVA 466
Score = 42.0 bits (97), Expect = 0.001
Identities = 27/90 (30%), Positives = 43/90 (47%), Gaps = 6/90 (6%)
Query: 258 GRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVCLWR---- 313
GRL G + R +S +E Y+P+ G W +ADL P +G+ G L+ R
Sbjct: 325 GRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSP 384
Query: 314 --PADTTAVVEYAVRTDAWLPVAELRRPQS 341
D++A+ Y T+ W P A + P++
Sbjct: 385 DGNTDSSALDCYNPMTNQWSPCAPMSVPRN 414
Score = 31.6 bits (70), Expect = 1.6
Identities = 29/97 (29%), Positives = 42/97 (43%), Gaps = 9/97 (9%)
Query: 291 LPQPAAGVPC-AQACGRLFVCL--WRPADTTAVVEYAVRTDAWLPVAELRRPQS-YGHCM 346
L +P +PC A GRL + + + Y WL +A+L+ P+S C+
Sbjct: 310 LHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCV 369
Query: 347 VAHRDSLYVV---RNGPSDDFLHCAIDCLNLATGQWT 380
V LY V N P + A+DC N T QW+
Sbjct: 370 VG--GLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWS 404
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 63.2 bits (152), Expect = 5e-10
Identities = 54/206 (26%), Positives = 85/206 (41%), Gaps = 12/206 (5%)
Query: 138 AELALPEARAYVAALRPSSYAAVSTHTPAPGFLEDASRTLCYLDEEEDAWRTLAALPLEA 197
A +++P R V + YA +H G + S + + E D W +A P+
Sbjct: 407 APMSVPRNRIGVGVIDGHIYAVGGSH----GCIHHNS--VERYEPERDEWHLVA--PMLT 458
Query: 198 STLLAGVATLGNKLYIVGGVRGASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFD 257
+ GVA L LY VGG G ++ + CY P+ W + + R +
Sbjct: 459 RRIGVGVAVLNRLLYAVGGFDGTNR--LNSAECYYPERNEWRMITAMNTIRSGAGVCVLH 516
Query: 258 GRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVCLWRPADT 317
+YA GG + ++SVERYD W+FVA + + + GR++V T
Sbjct: 517 NCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHT 576
Query: 318 --TAVVEYAVRTDAWLPVAELRRPQS 341
+V Y TD W V + +S
Sbjct: 577 FLDSVECYDPDTDTWSEVTRMTSGRS 602
Score = 52.8 bits (125), Expect = 7e-07
Identities = 41/125 (32%), Positives = 53/125 (42%), Gaps = 7/125 (5%)
Query: 178 CYLDEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGASK-EVVELGFCYDPDGG 236
CY E + WR + A+ S AGV L N +Y GG G + VE YD +
Sbjct: 489 CYYPERNE-WRMITAMNTIRSG--AGVCVLHNCIYAAGGYDGQDQLNSVER---YDVETE 542
Query: 237 TWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAA 296
TW R + GR+Y +GG T + SVE YDP WS V + +
Sbjct: 543 TWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRS 602
Query: 297 GVPCA 301
GV A
Sbjct: 603 GVGVA 607
Score = 51.6 bits (122), Expect = 1e-06
Identities = 40/138 (28%), Positives = 55/138 (39%), Gaps = 4/138 (2%)
Query: 166 APGFLEDASRTLCYLDEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGASKEVV 225
A G+ + L + + W LA L + S L V +G LY VGG +
Sbjct: 331 AGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCV--VGGLLYAVGGRNNSPDGNT 388
Query: 226 ELGF--CYDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAG 283
+ CY+P W PR + DG +YA+GG +SVERY+P
Sbjct: 389 DSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERD 448
Query: 284 CWSFVADLPQPAAGVPCA 301
W VA + GV A
Sbjct: 449 EWHLVAPMLTRRIGVGVA 466
Score = 42.0 bits (97), Expect = 0.001
Identities = 27/90 (30%), Positives = 43/90 (47%), Gaps = 6/90 (6%)
Query: 258 GRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVCLWR---- 313
GRL G + R +S +E Y+P+ G W +ADL P +G+ G L+ R
Sbjct: 325 GRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSP 384
Query: 314 --PADTTAVVEYAVRTDAWLPVAELRRPQS 341
D++A+ Y T+ W P A + P++
Sbjct: 385 DGNTDSSALDCYNPMTNQWSPCAPMSVPRN 414
Score = 31.6 bits (70), Expect = 1.6
Identities = 29/97 (29%), Positives = 42/97 (43%), Gaps = 9/97 (9%)
Query: 291 LPQPAAGVPC-AQACGRLFVCL--WRPADTTAVVEYAVRTDAWLPVAELRRPQS-YGHCM 346
L +P +PC A GRL + + + Y WL +A+L+ P+S C+
Sbjct: 310 LHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCV 369
Query: 347 VAHRDSLYVV---RNGPSDDFLHCAIDCLNLATGQWT 380
V LY V N P + A+DC N T QW+
Sbjct: 370 VG--GLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWS 404
>gi|11545731 gigaxonin [Homo sapiens]
Length = 597
Score = 62.4 bits (150), Expect = 8e-10
Identities = 39/120 (32%), Positives = 58/120 (48%), Gaps = 4/120 (3%)
Query: 173 ASRTLCYL-DEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGASKEVVELGFCY 231
A R +C L D W LA PL + GV + L++ GG + +K+ + G Y
Sbjct: 291 AMRCMCPLYDPNRQLWIELA--PLSMPRINHGVLSAEGFLFVFGG-QDENKQTLSSGEKY 347
Query: 232 DPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADL 291
DPD TW P ++ R++ + DG LY +GGE + S+E YD + W+ DL
Sbjct: 348 DPDANTWTALPPMNEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDL 407
Score = 57.0 bits (136), Expect = 3e-08
Identities = 46/198 (23%), Positives = 82/198 (41%), Gaps = 11/198 (5%)
Query: 194 PLEASTLLAGVATLGNK--LYIVGGVRGASKEVVELGFC----YDPDGGTWHEFPSPHQP 247
P + +LA G + VGG S++ C YDP+ W E P
Sbjct: 256 PQQGEAMLANFKPRGYSECIVTVGGEERVSRKPTAAMRCMCPLYDPNRQLWIELAPLSMP 315
Query: 248 RYDTALAGFDGRLYAIGGEFQ-RTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQACGR 306
R + + +G L+ GG+ + + +SS E+YDP A W+ + + + + G
Sbjct: 316 RINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALPPMNEARHNFGIVEIDGM 375
Query: 307 LFVCLWRPADTTAVVE--YAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRNGPSDDF 364
L++ + + Y + + W +L + G C A + +Y + G S
Sbjct: 376 LYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIG-CYAAMKKKIYAM-GGGSYGK 433
Query: 365 LHCAIDCLNLATGQWTAL 382
L +++C + T QWTA+
Sbjct: 434 LFESVECYDPRTQQWTAI 451
Score = 52.8 bits (125), Expect = 7e-07
Identities = 38/125 (30%), Positives = 55/125 (44%), Gaps = 7/125 (5%)
Query: 181 DEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGASKEVVELGFCYDPDGGTWHE 240
D + + W L P+ + G+ + LYI+GG G KE++ + CYD TW +
Sbjct: 348 DPDANTWTALP--PMNEARHNFGIVEIDGMLYILGGEDG-EKELISME-CYDIYSKTWTK 403
Query: 241 FPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPC 300
P R A ++YA+GG SVE YDP W+ + L + G
Sbjct: 404 QPDLTMVRKIGCYAAMKKKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFG--- 460
Query: 301 AQACG 305
A ACG
Sbjct: 461 AVACG 465
Score = 31.2 bits (69), Expect = 2.0
Identities = 18/61 (29%), Positives = 26/61 (42%), Gaps = 2/61 (3%)
Query: 205 ATLGNKLYIVGGVRGASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIG 264
A + K+Y +GG G+ ++ E CYDP W + R+ G LY G
Sbjct: 417 AAMKKKIYAMGG--GSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFG 474
Query: 265 G 265
G
Sbjct: 475 G 475
>gi|88196794 kelch-like 35 [Homo sapiens]
Length = 363
Score = 62.4 bits (150), Expect = 8e-10
Identities = 53/180 (29%), Positives = 82/180 (45%), Gaps = 16/180 (8%)
Query: 183 EEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGASKEVVELGFCYDPDGGTWHEFP 242
E W L +LP + A A L N +Y+ GG S +V + + TW +
Sbjct: 105 ESQRWTPLPSLPGYTRSEFAACA-LRNDVYVSGGHIN-SHDV----WMFSSHLHTWIKVA 158
Query: 243 SPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQ 302
S H+ R+ +A G+L+A+GG + SVERYDP + W+ A LP+ + A
Sbjct: 159 SLHKGRWRHKMAVVQGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVAS 218
Query: 303 ACGRLFV---CLWRPADTTAVVEYAVRTDAWLPVAELRRPQSYG-HCM--VAHRDSLYVV 356
G+LFV +T V + + D W LR P + C+ V+ D++YV+
Sbjct: 219 CAGKLFVIGGARQGGVNTDKVQCFDPKEDRW----SLRSPAPFSQRCLEAVSLEDTIYVM 274
Score = 50.8 bits (120), Expect = 2e-06
Identities = 38/128 (29%), Positives = 58/128 (45%), Gaps = 20/128 (15%)
Query: 181 DEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVR--GASKEVVELGFCYDPDGGTW 238
D + W A LP S+ A VA+ KL+++GG R G + + V+ C+DP W
Sbjct: 195 DPFSNTWAAAAPLPEAVSS--AAVASCAGKLFVIGGARQGGVNTDKVQ---CFDPKEDRW 249
Query: 239 H-EFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAG 297
P+P R A++ + +Y +GG +S + YDP W A LP P
Sbjct: 250 SLRSPAPFSQRCLEAVS-LEDTIYVMGGL-----MSKIFTYDPGTDVWGEAAVLPSP--- 300
Query: 298 VPCAQACG 305
++CG
Sbjct: 301 ---VESCG 305
Score = 39.7 bits (91), Expect = 0.006
Identities = 38/148 (25%), Positives = 58/148 (39%), Gaps = 13/148 (8%)
Query: 137 AAELALPEARAYVAALRPSSYAAVSTHTPAPGFLEDASRTLCYLDEEEDAWRTLAALPLE 196
AA LPEA + A + V G D + C+ D +ED W + P
Sbjct: 202 AAAAPLPEAVSSAAVASCAGKLFVIGGARQGGVNTD--KVQCF-DPKEDRWSLRSPAPFS 258
Query: 197 ASTLLAGVATLGNKLYIVGGVRGASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGF 256
L A +L + +Y++GG+ F YDP W E P +
Sbjct: 259 QRCLEA--VSLEDTIYVMGGLMSKI-------FTYDPGTDVWGEAAVLPSPVESCGVTVC 309
Query: 257 DGRLYAIGGEFQR-TPISSVERYDPAAG 283
DG+++ +GG R V +DP++G
Sbjct: 310 DGKVHILGGRDDRGESTDKVFTFDPSSG 337
>gi|23397572 kelch-like 34 [Homo sapiens]
Length = 644
Score = 62.4 bits (150), Expect = 8e-10
Identities = 50/150 (33%), Positives = 71/150 (47%), Gaps = 8/150 (5%)
Query: 15 GQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATLQVLRGDRPALAA 74
G F A R+LL +FR LF+S +E+RA + L V SA G + L + +L+
Sbjct: 37 GSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSLSM 96
Query: 75 EDELLQAVECAAFLQAP----ALARFLEHNLTSDNCALLCDAAAAFGLRDVFHSAALFIC 130
D + +E A++LQ R+LE L +NC + AA FGL +A I
Sbjct: 97 -DTVEDTLEAASYLQVTEALGLCGRYLERQLAPENCCFAANVAARFGLAHTLDAAERCIV 155
Query: 131 DGERELAAELALPEARAYVAALRPSSYAAV 160
+EL A A P A + L P+S AV
Sbjct: 156 SHLQELLARGAGP---AGLLELNPTSLRAV 182
Score = 43.5 bits (101), Expect = 4e-04
Identities = 43/160 (26%), Positives = 63/160 (39%), Gaps = 14/160 (8%)
Query: 181 DEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGV----RGASKEVVELGFCYDPDGG 236
D D W ALP V G +YI GG G + + +L + P+
Sbjct: 447 DLRRDRWTAAGALPRALHGHAGAVGDRG-VVYISGGKAGRGEGGASSLRDL-YVLGPEEQ 504
Query: 237 TWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQP-- 294
W + R+ +A G ++A G ++ P S +ERYDP A W+ + LP
Sbjct: 505 VWSKKAPMGTARFGHHMAVLRGAVFAFLGRYE--PFSEIERYDPGADQWTRLRPLPYDRF 562
Query: 295 AAGVPCAQACGRLFVCL-WRPA---DTTAVVEYAVRTDAW 330
G+ + L L WR + T VV Y + D W
Sbjct: 563 CYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYDLDLDRW 602
Score = 43.1 bits (100), Expect = 5e-04
Identities = 49/174 (28%), Positives = 66/174 (37%), Gaps = 20/174 (11%)
Query: 139 ELALPE--ARAYVAALRPSSYAAVSTHTPAPGFLEDASRTLCYLDEEEDAWRTLAALPLE 196
E+A P+ AR VAA P E + + D WR+L LP
Sbjct: 297 EVAAPQRAARGQVAAPEPEEEEEELEEEEEEEEWELTQNVVAF-DVYNHRWRSLTQLP-- 353
Query: 197 ASTLLAG--VATLGNKLYIVGG----------VRGASKEVVELGFCYDPDGGTWHEFPSP 244
T L G V T GN L+++GG + S+ V YDP W E P+
Sbjct: 354 --TPLLGHSVCTAGNFLFVLGGESPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAM 411
Query: 245 HQPRYDTALAGFDGRLYAIGG-EFQRTPISSVERYDPAAGCWSFVADLPQPAAG 297
+ R RL A+GG ++SVE YD W+ LP+ G
Sbjct: 412 REARAHFWCGAVGERLLAVGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHG 465
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.138 0.435
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,941,065
Number of Sequences: 37866
Number of extensions: 883531
Number of successful extensions: 2368
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 59
Number of HSP's successfully gapped in prelim test: 27
Number of HSP's that attempted gapping in prelim test: 1873
Number of HSP's gapped (non-prelim): 258
length of query: 458
length of database: 18,247,518
effective HSP length: 106
effective length of query: 352
effective length of database: 14,233,722
effective search space: 5010270144
effective search space used: 5010270144
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.