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Search of human proteins with 148746218
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148746218 TAO kinase 3 [Homo sapiens]
(898 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148746218 TAO kinase 3 [Homo sapiens] 1779 0.0
gi|45439370 TAO kinase 1 [Homo sapiens] 1320 0.0
gi|4759208 TAO kinase 2 isoform 1 [Homo sapiens] 1186 0.0
gi|45505130 TAO kinase 2 isoform 2 [Homo sapiens] 932 0.0
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 247 4e-65
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 241 3e-63
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 238 1e-62
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 233 5e-61
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 233 5e-61
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 233 5e-61
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 233 5e-61
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 229 9e-60
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 229 9e-60
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 229 1e-59
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 229 1e-59
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 229 1e-59
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 229 1e-59
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 227 4e-59
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 225 1e-58
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 224 4e-58
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 216 8e-56
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 214 2e-55
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 214 2e-55
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 214 2e-55
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 214 2e-55
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 214 4e-55
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 214 4e-55
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 209 7e-54
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 207 4e-53
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 201 2e-51
>gi|148746218 TAO kinase 3 [Homo sapiens]
Length = 898
Score = 1779 bits (4607), Expect = 0.0
Identities = 898/898 (100%), Positives = 898/898 (100%)
Query: 1 MRKGVLKDPEIADLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGK 60
MRKGVLKDPEIADLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGK
Sbjct: 1 MRKGVLKDPEIADLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGK 60
Query: 61 QTHEKWQDILKEVKFLRQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQ 120
QTHEKWQDILKEVKFLRQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQ
Sbjct: 61 QTHEKWQDILKEVKFLRQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQ 120
Query: 121 EVEIAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVG 180
EVEIAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVG
Sbjct: 121 EVEIAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVG 180
Query: 181 TPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPT 240
TPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPT
Sbjct: 181 TPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPT 240
Query: 241 LQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVRRDRPLRVLIDLIQRTKDAVREL 300
LQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVRRDRPLRVLIDLIQRTKDAVREL
Sbjct: 241 LQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVRRDRPLRVLIDLIQRTKDAVREL 300
Query: 301 DNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPSMSVSTGSQ 360
DNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPSMSVSTGSQ
Sbjct: 301 DNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPSMSVSTGSQ 360
Query: 361 SSSVNSMQEVMDESSSELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDPRPEPRPTQ 420
SSSVNSMQEVMDESSSELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDPRPEPRPTQ
Sbjct: 361 SSSVNSMQEVMDESSSELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDPRPEPRPTQ 420
Query: 421 SVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQLIALEN 480
SVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQLIALEN
Sbjct: 421 SVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQLIALEN 480
Query: 481 KLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQQILAQ 540
KLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQQILAQ
Sbjct: 481 KLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQQILAQ 540
Query: 541 QKKDLTTFLESQKKQYKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEEEAHL 600
QKKDLTTFLESQKKQYKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEEEAHL
Sbjct: 541 QKKDLTTFLESQKKQYKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEEEAHL 600
Query: 601 LTQQRLYYDKNCRFFKRKIMIKRHEVEQQNIREELNKKRTQKEMEHAMLIRHDESTRELE 660
LTQQRLYYDKNCRFFKRKIMIKRHEVEQQNIREELNKKRTQKEMEHAMLIRHDESTRELE
Sbjct: 601 LTQQRLYYDKNCRFFKRKIMIKRHEVEQQNIREELNKKRTQKEMEHAMLIRHDESTRELE 660
Query: 661 YRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIK 720
YRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIK
Sbjct: 661 YRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIK 720
Query: 721 KQFQDTCKVQTKQYKALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMM 780
KQFQDTCKVQTKQYKALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMM
Sbjct: 721 KQFQDTCKVQTKQYKALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMM 780
Query: 781 ASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRA 840
ASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRA
Sbjct: 781 ASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRA 840
Query: 841 HLEQKIEEELAALQKERSERIKNLLERQEREIETFDMESLRMGFGNLVTLDFPKEDYR 898
HLEQKIEEELAALQKERSERIKNLLERQEREIETFDMESLRMGFGNLVTLDFPKEDYR
Sbjct: 841 HLEQKIEEELAALQKERSERIKNLLERQEREIETFDMESLRMGFGNLVTLDFPKEDYR 898
>gi|45439370 TAO kinase 1 [Homo sapiens]
Length = 1001
Score = 1320 bits (3417), Expect = 0.0
Identities = 662/900 (73%), Positives = 775/900 (86%), Gaps = 9/900 (1%)
Query: 2 RKGVLKDPEIADLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQ 61
R G LKDPEIA+LF+K+DPE+LF L EIGHGSFGAVYFA + T+EVVAIKKMSYSGKQ
Sbjct: 6 RAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQ 65
Query: 62 THEKWQDILKEVKFLRQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQE 121
+ EKWQDI+KEVKFL+++KHPN+IEYKGCYL+EHTAWLVMEYCLGSASDLLEVHKKPLQE
Sbjct: 66 STEKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQE 125
Query: 122 VEIAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGT 181
VEIAAITHGAL GLAYLHSH +IHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGT
Sbjct: 126 VEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGT 185
Query: 182 PYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTL 241
PYWMAPEVILAMDEGQYDGKVD+WSLGITCIELAERKPPLFNMNAMSALYHIAQN+SPTL
Sbjct: 186 PYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTL 245
Query: 242 QSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVRRDRPLRVLIDLIQRTKDAVRELD 301
QSNEW+D FR FVD CLQKIPQ+RPTS ELL+H FV R+RP VLIDLIQRTKDAVRELD
Sbjct: 246 QSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETVLIDLIQRTKDAVRELD 305
Query: 302 NLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPSMSVSTGSQS 361
NLQYRKMKK+LFQE NGP E+QE+EE+ +HG ++S+GSN SIPSMS+S SQS
Sbjct: 306 NLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPSMSISASSQS 365
Query: 362 SSVNSMQEVMDESSSELVMMHDDESTINSSSSVVH-KKDHVFIRDEAGHGDPRP---EPR 417
SSVNS+ +V D+ S EL MM D T+ S+SSV+H K + R+E GDPR +P+
Sbjct: 366 SSVNSLPDVSDDKS-ELDMMEGDH-TVMSNSSVIHLKPEEENYREE---GDPRTRASDPQ 420
Query: 418 PTQSVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQLIA 477
V HYRNRE FATI++ASLVTRQ+ EHEQ++ELREQMSGYKRMRRQHQKQL+
Sbjct: 421 SPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMT 480
Query: 478 LENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQQI 537
LENKLKAEMDEHRL+L K++ET NN + E+EKL KK A +EKEAKV + +EKKFQQ I
Sbjct: 481 LENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKFQQHI 540
Query: 538 LAQQKKDLTTFLESQKKQYKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEEE 597
AQQKK+L +FLESQK++YK+ KE++KEE+NE+ STPKKEKQE +SK KEN+QH QAEEE
Sbjct: 541 QAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEE 600
Query: 598 AHLLTQQRLYYDKNCRFFKRKIMIKRHEVEQQNIREELNKKRTQKEMEHAMLIRHDESTR 657
A+LL +QR Y + CR FKR++++ RH +EQ +REELNK++TQK++EHAML+R ES +
Sbjct: 601 ANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQ 660
Query: 658 ELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEM 717
ELE+R L+T+QK+R +LIRLQHQTEL NQLEYNKRREREL RKHVME+RQQPK+LK+ E+
Sbjct: 661 ELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKEL 720
Query: 718 QIKKQFQDTCKVQTKQYKALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSIN 777
QIKKQFQDTCK+QT+QYKAL+NH LE TPK+EHK +LK LK+EQTRKLAILAEQY+ SIN
Sbjct: 721 QIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSIN 780
Query: 778 EMMASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSL 837
EM+++QALRLDEAQEAECQ L++QLQQE+ELLNAYQSKIKMQ EAQH+REL++LEQRVSL
Sbjct: 781 EMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSL 840
Query: 838 RRAHLEQKIEEELAALQKERSERIKNLLERQEREIETFDMESLRMGFGNLVTLDFPKEDY 897
RRA LEQKIEEE+ ALQ ER+ERI++LLERQ REIE FD ES+R+GF N+V + E +
Sbjct: 841 RRALLEQKIEEEMLALQNERTERIRSLLERQAREIEAFDSESMRLGFSNMVLSNLSPEAF 900
>gi|4759208 TAO kinase 2 isoform 1 [Homo sapiens]
Length = 1049
Score = 1186 bits (3069), Expect = 0.0
Identities = 598/921 (64%), Positives = 736/921 (79%), Gaps = 27/921 (2%)
Query: 2 RKGVLKDPEIADLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQ 61
R G LKDP++A+LF+KDDPE+LF L EIGHGSFGAVYFA + SEVVAIKKMSYSGKQ
Sbjct: 6 RAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQ 65
Query: 62 THEKWQDILKEVKFLRQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQE 121
++EKWQDI+KEV+FL++L+HPNTI+Y+GCYL+EHTAWLVMEYCLGSASDLLEVHKKPLQE
Sbjct: 66 SNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQE 125
Query: 122 VEIAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGT 181
VEIAA+THGAL GLAYLHSH +IHRD+KAGNILL+EPG VKL DFGSAS+ +PANSFVGT
Sbjct: 126 VEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFVGT 185
Query: 182 PYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTL 241
PYWMAPEVILAMDEGQYDGKVD+WSLGITCIELAERKPPLFNMNAMSALYHIAQN+SP L
Sbjct: 186 PYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVL 245
Query: 242 QSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVRRDRPLRVLIDLIQRTKDAVRELD 301
QS W++ FR FVD CLQKIPQ+RPTS LL+H FV R+RP V++DLIQRTKDAVRELD
Sbjct: 246 QSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELD 305
Query: 302 NLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPSMSVSTGSQS 361
NLQYRKMKKILFQE NGP E+ E+EE++E + SL S+HS+PSMS+S SQS
Sbjct: 306 NLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSISASSQS 365
Query: 362 SSVNSMQEVMDESSSE-----------------LVMMHDDESTINSSSSVVHK---KDHV 401
SSVNS+ + D E + MM + E T+ S SS++H+ D++
Sbjct: 366 SSVNSLADASDNEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNL 425
Query: 402 FIRDEAGHGDPRP-----EPRPTQSVQS--QALHYRNRERFATIKSASLVTRQIHEHEQE 454
+ P P P PT + S + + RNR+ FATI++ASLV+RQI EHEQ+
Sbjct: 426 YDDPYQPEITPSPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQD 485
Query: 455 NELREQMSGYKRMRRQHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKK 514
+ LREQ+SGYKRMRRQHQKQL+ALE++L+ E +EH +LQ+E+E E EKLA++
Sbjct: 486 SALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARR 545
Query: 515 QVAIIEKEAKVAAADEKKFQQQILAQQKKDLTTFLESQKKQYKICKEKIKEEMNEDHSTP 574
AI EKEA+ A A+E+KFQQ IL QQKK+L LE+QK+ YK+ KE++KEE+ E+ STP
Sbjct: 546 HQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQENPSTP 605
Query: 575 KKEKQERISKHKENLQHTQAEEEAHLLTQQRLYYDKNCRFFKRKIMIKRHEVEQQNIREE 634
K+EK E + + KE LQ QAEEEA LL +QR Y++ CR +KRK+++ RH ++Q +RE+
Sbjct: 606 KREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQDLLRED 665
Query: 635 LNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRE 694
LNKK+TQK++E A+L+R E+TRELE RQL +Q+ R +L RLQHQTEL NQLEYNKRRE
Sbjct: 666 LNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRRE 725
Query: 695 RELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQLEVTPKNEHKTIL 754
+EL +KH ++RQQPK+LK+ E+QIKKQFQ+TCK+QT+QYKAL+ H LE TPK +HK++L
Sbjct: 726 QELRQKHAAQVRQQPKSLKSKELQIKKQFQETCKIQTRQYKALRAHLLETTPKAQHKSLL 785
Query: 755 KTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQLQQEMELLNAYQS 814
K LK+EQTRKLAILAEQY+QSI+EM++SQALRLDE QEAE QALR QLQQE+ELLNAYQS
Sbjct: 786 KRLKEEQTRKLAILAEQYDQSISEMLSSQALRLDETQEAEFQALRQQLQQELELLNAYQS 845
Query: 815 KIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKNLLERQEREIET 874
KIK++TE+QHEREL++LEQRV+LRRA LEQ++EEEL ALQ RSERI++LLERQ REIE
Sbjct: 846 KIKIRTESQHERELRELEQRVALRRALLEQRVEEELLALQTGRSERIRSLLERQAREIEA 905
Query: 875 FDMESLRMGFGNLVTLDFPKE 895
FD ES+R+GF ++ P E
Sbjct: 906 FDAESMRLGFSSMALGGIPAE 926
>gi|45505130 TAO kinase 2 isoform 2 [Homo sapiens]
Length = 1235
Score = 932 bits (2410), Expect = 0.0
Identities = 468/739 (63%), Positives = 578/739 (78%), Gaps = 27/739 (3%)
Query: 2 RKGVLKDPEIADLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQ 61
R G LKDP++A+LF+KDDPE+LF L EIGHGSFGAVYFA + SEVVAIKKMSYSGKQ
Sbjct: 6 RAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQ 65
Query: 62 THEKWQDILKEVKFLRQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQE 121
++EKWQDI+KEV+FL++L+HPNTI+Y+GCYL+EHTAWLVMEYCLGSASDLLEVHKKPLQE
Sbjct: 66 SNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQE 125
Query: 122 VEIAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGT 181
VEIAA+THGAL GLAYLHSH +IHRD+KAGNILL+EPG VKL DFGSAS+ +PANSFVGT
Sbjct: 126 VEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFVGT 185
Query: 182 PYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTL 241
PYWMAPEVILAMDEGQYDGKVD+WSLGITCIELAERKPPLFNMNAMSALYHIAQN+SP L
Sbjct: 186 PYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVL 245
Query: 242 QSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVRRDRPLRVLIDLIQRTKDAVRELD 301
QS W++ FR FVD CLQKIPQ+RPTS LL+H FV R+RP V++DLIQRTKDAVRELD
Sbjct: 246 QSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELD 305
Query: 302 NLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPSMSVSTGSQS 361
NLQYRKMKKILFQE NGP E+ E+EE++E + SL S+HS+PSMS+S SQS
Sbjct: 306 NLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSISASSQS 365
Query: 362 SSVNSMQEVMDE-----------------SSSELVMMHDDESTINSSSSVVHK---KDHV 401
SSVNS+ + D + E+ MM + E T+ S SS++H+ D++
Sbjct: 366 SSVNSLADASDNEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNL 425
Query: 402 FIRDEAGHGDPRP-----EPRPTQSVQS--QALHYRNRERFATIKSASLVTRQIHEHEQE 454
+ P P P PT + S + + RNR+ FATI++ASLV+RQI EHEQ+
Sbjct: 426 YDDPYQPEITPSPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQD 485
Query: 455 NELREQMSGYKRMRRQHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKK 514
+ LREQ+SGYKRMRRQHQKQL+ALE++L+ E +EH +LQ+E+E E EKLA++
Sbjct: 486 SALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARR 545
Query: 515 QVAIIEKEAKVAAADEKKFQQQILAQQKKDLTTFLESQKKQYKICKEKIKEEMNEDHSTP 574
AI EKEA+ A A+E+KFQQ IL QQKK+L LE+QK+ YK+ KE++KEE+ E+ STP
Sbjct: 546 HQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQENPSTP 605
Query: 575 KKEKQERISKHKENLQHTQAEEEAHLLTQQRLYYDKNCRFFKRKIMIKRHEVEQQNIREE 634
K+EK E + + KE LQ QAEEEA LL +QR Y++ CR +KRK+++ RH ++Q +RE+
Sbjct: 606 KREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQDLLRED 665
Query: 635 LNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRE 694
LNKK+TQK++E A+L+R E+TRELE RQL +Q+ R +L RLQHQTEL NQLEYNKRRE
Sbjct: 666 LNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRRE 725
Query: 695 RELHRKHVMELRQQPKNLK 713
+EL +KH ++RQQPK+LK
Sbjct: 726 QELRQKHAAQVRQQPKSLK 744
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 247 bits (630), Expect = 4e-65
Identities = 168/488 (34%), Positives = 251/488 (51%), Gaps = 55/488 (11%)
Query: 20 PEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQL 79
PEE+F L ++G GS+G+VY A + T ++VAIK++ Q+I+KE+ ++Q
Sbjct: 26 PEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVP-----VESDLQEIIKEISIMQQC 80
Query: 80 KHPNTIEYKGCYLKEHTAWLVMEYC-LGSASDLLEVHKKPLQEVEIAAITHGALHGLAYL 138
P+ ++Y G Y K W+VMEYC GS SD++ + K L E EIA I L GL YL
Sbjct: 81 DSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYL 140
Query: 139 HSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPA----NSFVGTPYWMAPEVILAMD 194
H IHRDIKAGNILL G KLADFG A + N+ +GTP+WMAPEVI
Sbjct: 141 HFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI---Q 197
Query: 195 EGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQSNE-WTDSFRRF 253
E Y+ DIWSLGIT IE+AE KPP +++ M A++ I N PT + E W+D+F F
Sbjct: 198 EIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDF 257
Query: 254 VDYCLQKIPQERPTSAELLRHDFVRRDRPLRVLIDLIQRTKDAVRELDNLQYRKMKKILF 313
V CL K P++R T+ +LL+H FVR + + +L DLI D + Q R++
Sbjct: 258 VKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREV----- 312
Query: 314 QETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPSMSVSTGSQSSSVNSMQEVMDE 373
Q+DEE+SE EMDS +M + G + +V + D
Sbjct: 313 ----------DQDDEENSEED-----EMDS-------GTMVRAVGDEMGTVRVASTMTDG 350
Query: 374 SSSELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDPRPEPRPTQSVQSQALHY-RNR 432
+++ ++ HDD + V++ + DE G + Q + L Y +
Sbjct: 351 ANT--MIEHDDTLPSQLGTMVINAE------DEEEEGTMKRRDETMQPAKPSFLEYFEQK 402
Query: 433 ERFATIKSASLVTRQIHEHEQENELREQMSGYKRMR----RQHQKQLIALENKLKAEMDE 488
E+ I S ++ + ++ Q Y+ ++ QK+L+AL+ ++ E++E
Sbjct: 403 EKENQINSFGKSVPGPLKNSSDWKI-PQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEE 461
Query: 489 HRLKLQKE 496
R K Q +
Sbjct: 462 IRQKYQSK 469
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 241 bits (614), Expect = 3e-63
Identities = 223/892 (25%), Positives = 411/892 (46%), Gaps = 86/892 (9%)
Query: 19 DPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQ 78
DP E++ + E+G G+FG VY A N T + A K + ++ E+ +D + E++ L
Sbjct: 31 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIE---TKSEEELEDYIVEIEILAT 87
Query: 79 LKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVH-KKPLQEVEIAAITHGALHGLAY 137
HP ++ G Y + W+++E+C G A D + + + L E +I + L L +
Sbjct: 88 CDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNF 147
Query: 138 LHSHALIHRDIKAGNILLTEPGQVKLADFGSASM----ASPANSFVGTPYWMAPEVILA- 192
LHS +IHRD+KAGN+L+T G ++LADFG ++ +SF+GTPYWMAPEV++
Sbjct: 148 LHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCE 207
Query: 193 -MDEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQS-NEWTDSF 250
M + YD K DIWSLGIT IE+A+ +PP +N M L IA++D PTL + ++W+ F
Sbjct: 208 TMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEF 267
Query: 251 RRFVDYCLQKIPQERPTSAELLRHDFVRRDRPLRVLIDLIQRTKDAVRELDNLQYRKMKK 310
R F+ L K P+ RP++A+LL H FV + L +L+ K V E
Sbjct: 268 RDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVME----------- 316
Query: 311 ILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPSMSVSTG-SQSSSVNSMQE 369
E +G + +EED+ S S S PS++ +S S
Sbjct: 317 ----EIEDG---RDEGEEEDAVDAASTLENHTQNSSEVSPPSLNADKPLEESPSTPLAPS 369
Query: 370 VMDESSSELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDPRP--EPRP-TQSVQSQA 426
+S +E + ++ ++S V V +E G P P + RP + + Q
Sbjct: 370 QSQDSVNEPCSQPSGDRSLQTTSPPV-----VAPGNENGLAVPVPLRKSRPVSMDARIQV 424
Query: 427 LHYRN-RERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQLIALENKLKAE 485
+ E+ + A+ +++ + + E + G K + A K +
Sbjct: 425 AQEKQVAEQGGDLSPAANRSQKASQSRPNSSALETLGGEKLANGSLEPPAQAAPGPSKRD 484
Query: 486 MDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQQILAQQKKDL 545
D L + ++ + N S +L + KE + + K ++ L + +K +
Sbjct: 485 SDCSSLCTSESMD-YGTNLSTDLS---------LNKEMGSLSIKDPKLYKKTLKRTRKFV 534
Query: 546 TTFLESQKKQYKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEEEAHLLTQQR 605
+E KI E K++ ++ ++ R+ + +E+ TQ L +
Sbjct: 535 VDGVEVSITTSKIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQ------LSNKHE 588
Query: 606 LYYDKNCRFFKRKIMIKR--HEVEQQNIREELNKKRTQKEMEHAMLIRHDESTRELEYRQ 663
L ++ + F+++I K+ + E +N+ + ++ + E +HA+ R + LE +
Sbjct: 589 LQLEQMHKRFEQEINAKKKFFDTELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDR 648
Query: 664 LHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQF 723
+T + ++ L++ E++N++E R++R+ K ME Q K L + + KQ
Sbjct: 649 DYTRFQEQLKLMK----KEVKNEVEKLPRQQRKESMKQKMEEHTQKKQLLDRDF-VAKQK 703
Query: 724 QDTCKVQTKQYKALKNHQLEVTPKNEHKTILKTLKDEQTR-KLAILAEQYEQSINEMMAS 782
+D ++ + +++ E+ K E + ++K K E R + A L E E + E
Sbjct: 704 ED---LELAMKRLTTDNRREICDK-ERECLMK--KQELLRDREAALWEMEEHQLQERHQL 757
Query: 783 QALRLDEAQEAECQALRLQLQQEMELLNAY------QSKIKMQTEAQHERELQKLEQRVS 836
+L + + L + ++E E + Y Q K++ Q E ++Q+ E +
Sbjct: 758 VKQQLKDQYFLQRHELLRKHEKEREQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTR 817
Query: 837 L----RRAHL-------EQKIEEELAALQKERSERIKNLLERQEREIETFDM 877
+ + H+ EQ+ + + + Q+E+ ++ + L ++Q+ E + DM
Sbjct: 818 MAMYKKSLHINGGGSAAEQREKIKQFSQQEEKRQKSERLQQQQKHENQMRDM 869
Score = 38.5 bits (88), Expect = 0.028
Identities = 41/205 (20%), Positives = 87/205 (42%), Gaps = 18/205 (8%)
Query: 677 LQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKA 736
+ + T L L NK E+ + + + K LK + +K D +V K
Sbjct: 496 MDYGTNLSTDLSLNK----EMGSLSIKDPKLYKKTLK----RTRKFVVDGVEVSITTSKI 547
Query: 737 LKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQ---EA 793
+ + K+E ++ L+ ++ R+L +L ++ ++ ++ L+L++ E
Sbjct: 548 ISEDE----KKDEE---MRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQ 600
Query: 794 ECQALRLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAAL 853
E A + E+E L Q + + E H ++ +R+ L + + +E+L +
Sbjct: 601 EINAKKKFFDTELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKLM 660
Query: 854 QKERSERIKNLLERQEREIETFDME 878
+KE ++ L +Q +E ME
Sbjct: 661 KKEVKNEVEKLPRQQRKESMKQKME 685
Score = 35.8 bits (81), Expect = 0.18
Identities = 49/221 (22%), Positives = 95/221 (42%), Gaps = 23/221 (10%)
Query: 431 NRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQLIALENKLKAEMDEHR 490
NR + L+ +Q ++E L E + + Q + QL+ + K + + H
Sbjct: 717 NRREICDKERECLMKKQELLRDREAALWEM----EEHQLQERHQLVKQQLKDQYFLQRHE 772
Query: 491 L--KLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQQILAQQKKDLTTF 548
L K +KE E + +E+L +Q + K+ ++ K +A KK L
Sbjct: 773 LLRKHEKEREQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTR----MAMYKKSLHIN 828
Query: 549 LESQKKQYKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEEEAHLLTQQRLYY 608
+ + EKIK+ ++ K E+ ++ KH+ ++ A+ E+++ Q+L
Sbjct: 829 GGGSAAEQR---EKIKQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCESNMSELQQLQN 885
Query: 609 DKNCRFF------KRKIMIKRHEVEQQNIREELNKKRTQKE 643
+K C K K + + H QN++E +K R +K+
Sbjct: 886 EK-CHLLVEHETQKLKALDESH---NQNLKEWRDKLRPRKK 922
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 238 bits (608), Expect = 1e-62
Identities = 139/372 (37%), Positives = 209/372 (56%), Gaps = 28/372 (7%)
Query: 20 PEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQL 79
PEE+F L ++G GS+G+V+ A + + +VVAIK++ Q+I+KE+ ++Q
Sbjct: 23 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVP-----VESDLQEIIKEISIMQQC 77
Query: 80 KHPNTIEYKGCYLKEHTAWLVMEYC-LGSASDLLEVHKKPLQEVEIAAITHGALHGLAYL 138
P ++Y G Y K W+VMEYC GS SD++ + K L E EIA I L GL YL
Sbjct: 78 DSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYL 137
Query: 139 HSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPA----NSFVGTPYWMAPEVILAMD 194
H IHRDIKAGNILL G KLADFG A + N+ +GTP+WMAPEVI
Sbjct: 138 HFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI---Q 194
Query: 195 EGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQSNE-WTDSFRRF 253
E Y+ DIWSLGIT IE+AE KPP +++ M A++ I N PT + E W+D F F
Sbjct: 195 EIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDF 254
Query: 254 VDYCLQKIPQERPTSAELLRHDFVRRDRPLRVLIDLIQRTKDAVRELDNLQYRKMKKILF 313
V CL K P++R T+ +LL+H F++ +P+ +L DLI + + Q R++++
Sbjct: 255 VKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQRELEE--- 311
Query: 314 QETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPSMSVSTGSQSSSVNSMQEVMDE 373
E DE++ + T + ++S+G+ + +M S G+Q + + +++
Sbjct: 312 --------EEENSDEDELDSHTMVKTSVESVGTMRATSTM--SEGAQ-TMIEHNSTMLES 360
Query: 374 SSSELVMMHDDE 385
+V+ +DE
Sbjct: 361 DLGTMVINSEDE 372
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 233 bits (595), Expect = 5e-61
Identities = 168/524 (32%), Positives = 260/524 (49%), Gaps = 61/524 (11%)
Query: 13 DLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKE 72
DL DP +F + +G+G++G VY + T ++ AIK M +G + E I +E
Sbjct: 14 DLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEE----IKQE 69
Query: 73 VKFLRQLKHPNTIE-YKGCYLKEHTA------WLVMEYC-LGSASDLLEVHK-KPLQEVE 123
+ L++ H I Y G ++K++ WLVME+C GS +DL++ K L+E
Sbjct: 70 INMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEW 129
Query: 124 IAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPA----NSFV 179
IA I L GL++LH H +IHRDIK N+LLTE +VKL DFG ++ N+F+
Sbjct: 130 IAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFI 189
Query: 180 GTPYWMAPEVILAMDEGQ---YDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQN 236
GTPYWMAPEVI A DE YD K D+WSLGIT IE+AE PPL +M+ M AL+ I +N
Sbjct: 190 GTPYWMAPEVI-ACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN 248
Query: 237 DSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVR---RDRPLRV-LIDLIQR 292
+P L+S +W+ F+ F++ CL K +RP + +L++H F+R +R +R+ L D I R
Sbjct: 249 PAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDR 308
Query: 293 TKDAVRELDNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPS 352
TK E D +Y +E +E+E DS +S+
Sbjct: 309 TKKKRGEKDETEYEYSG------------SEEEEEENDSGEPSSILNLPGESTLRRDFLR 356
Query: 353 MSVSTGSQSSSVNSMQEVMDESSSELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDP 412
+ ++ +S ++ Q + +E H + + +K+ R
Sbjct: 357 LQLANKERSEALRRQQLEQQQRENE---EHKRQLLAERQKRIEEQKEQ---RRRLEEQQR 410
Query: 413 RPEPRPTQSVQSQALHY-----RNRERFATIKSASLVTRQIHEHEQENELREQ------- 460
R + Q + Q HY R ER + RQ+ E +++ E+ +Q
Sbjct: 411 REKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQA 470
Query: 461 -MSGYKRMRRQHQKQLIALENKLKAEMD-----EHRLKLQKEVE 498
+ YKR + + Q+Q L+ +LK E D +H+ + Q+ VE
Sbjct: 471 LLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVE 514
Score = 54.7 bits (130), Expect = 4e-07
Identities = 45/211 (21%), Positives = 102/211 (48%), Gaps = 12/211 (5%)
Query: 622 KRHEVEQQNIREELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQT 681
++ E E + E ++ ++L EST ++ +L K R + +R Q
Sbjct: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLE 374
Query: 682 ELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQ 741
+ + + E +KR+ +K + E ++Q + L+ + + K+ + + Q + Y+ +
Sbjct: 375 QQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRRE 434
Query: 742 LEVTPKNEHKTILKTLKDEQTRKLAILAEQ--YEQSINEMMASQALRLDEAQEAECQALR 799
E + ++ +E+ R+L IL +Q +EQ++ ++ + +L+E ++AE L+
Sbjct: 435 EERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQAL--LLEYKRKQLEEQRQAE--RLQ 490
Query: 800 LQLQQEMELLNAYQSKIKMQTEAQHERELQK 830
QL+QE + L + +Q + Q +R ++K
Sbjct: 491 RQLKQERDYL------VSLQHQRQEQRPVEK 515
Score = 49.7 bits (117), Expect = 1e-05
Identities = 47/253 (18%), Positives = 121/253 (47%), Gaps = 14/253 (5%)
Query: 416 PRPTQSVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQL 475
P Q ++ + + ER I+ + R + +++E + SG + ++
Sbjct: 278 PATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGE 337
Query: 476 IALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQ 535
+ L E R L+ ++ + ++ ++L ++Q E + ++ A +K+ ++
Sbjct: 338 PSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEE 397
Query: 536 QILAQQKKDLTTFLESQKKQYKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAE 595
Q +Q++ L E Q+++ ++ K++ +E+ ++E++ R ++H++ Q E
Sbjct: 398 Q--KEQRRRLE---EQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLE 452
Query: 596 EEAHLL--TQQRLYYDKNCRFFKRKIMIKRHEVEQQNIREELNKKRTQKEMEHAMLIRHD 653
EE L QQ+L +++ + KR ++E+Q E L +++ ++E ++ + ++H
Sbjct: 453 EEQRQLEILQQQLLHEQ-----ALLLEYKRKQLEEQRQAERL-QRQLKQERDYLVSLQHQ 506
Query: 654 -ESTRELEYRQLH 665
+ R +E + L+
Sbjct: 507 RQEQRPVEKKPLY 519
Score = 48.9 bits (115), Expect = 2e-05
Identities = 64/291 (21%), Positives = 131/291 (45%), Gaps = 40/291 (13%)
Query: 439 KSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQLIALENKLKAEMDEHRLKLQKEVE 498
K S + + ++ + EQ+ + +R Q ++ + ++ LK +D + K ++ E
Sbjct: 261 KFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQ--LKDHIDRTKKKRGEKDE 318
Query: 499 THANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQQILAQQKKDLTTFLESQKKQYKI 558
T S E E+ E + + E ++ L Q L ++++ +
Sbjct: 319 TEYEYSGSEEEEEENDSG---EPSSILNLPGESTLRRDFLRLQ-------LANKERSEAL 368
Query: 559 CKEKIKEEMNEDHSTPKK---EKQERISKHKENLQHTQAEE--EAHLLTQQ----RLYYD 609
+++++++ E+ ++ E+Q+RI + KE + + ++ E L QQ R +Y+
Sbjct: 369 RRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYE 428
Query: 610 KNCRFFKRKIMIKRHEVEQQNIREELNKKRTQKEM-------EHAMLIRHDESTRELEYR 662
+ R R+ +R E EQ+ IR +L +++ Q E+ E A+L+ + E E R
Sbjct: 429 EQMR---REEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLE-EQR 484
Query: 663 QLHTLQKL----RMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQP 709
Q LQ+ R L+ LQHQ + + +E ++ H K M ++P
Sbjct: 485 QAERLQRQLKQERDYLVSLQHQRQEQRPVE----KKPLYHYKEGMSPSEKP 531
Score = 42.7 bits (99), Expect = 0.002
Identities = 42/197 (21%), Positives = 88/197 (44%), Gaps = 9/197 (4%)
Query: 689 YNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKV-----QTKQYKALKNHQLE 743
+++R E KH +R QP N + + +Q+K T K +T+ + + E
Sbjct: 274 HSQRPATEQLMKHPF-IRDQP-NERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEE 331
Query: 744 VTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQLQ 803
E +IL + R+ + + + +E + Q L + +E E +L +
Sbjct: 332 ENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLE-QQQRENEEHKRQLLAE 390
Query: 804 QEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKN 863
++ + + + +++ + + E+EL+K ++R RR + EQ EE + E I+
Sbjct: 391 RQKRIEEQKEQRRRLEEQQRREKELRKQQER-EQRRHYEEQMRREEERRRAEHEQEYIRR 449
Query: 864 LLERQEREIETFDMESL 880
LE ++R++E + L
Sbjct: 450 QLEEEQRQLEILQQQLL 466
Score = 41.6 bits (96), Expect = 0.003
Identities = 56/237 (23%), Positives = 96/237 (40%), Gaps = 42/237 (17%)
Query: 633 EELNKKRTQK---EMEHAMLIRHDESTRELEYRQLHTL---QKLRMDLIRLQHQTELENQ 686
+ KKR +K E E++ +E E + L LR D +RLQ
Sbjct: 307 DRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA------ 360
Query: 687 LEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQLEVTP 746
NK R L R+ +L QQ + + + Q+ + Q + Q +Q + L
Sbjct: 361 ---NKERSEALRRQ---QLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRL--------- 405
Query: 747 KNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQA--LRLQLQQ 804
+EQ R+ L +Q E+ Q R +E + AE + +R QL++
Sbjct: 406 ------------EEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEE 453
Query: 805 EMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEE-LAALQKERSER 860
E L Q ++ + E + ++LE++ R + K E + L +LQ +R E+
Sbjct: 454 EQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQ 510
Score = 38.5 bits (88), Expect = 0.028
Identities = 59/280 (21%), Positives = 118/280 (42%), Gaps = 48/280 (17%)
Query: 618 KIMIKRHEVEQQNIREELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRL 677
++ K+ + Q+ E K + L++H + RQ+ K +D +
Sbjct: 252 RLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKK 311
Query: 678 QHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAM--EMQIKKQFQDTCKVQTKQYK 735
+ + E + EY+ E E +P ++ + E +++ F ++ +
Sbjct: 312 KRGEKDETEYEYSGSEEEEEENDS-----GEPSSILNLPGESTLRRDFLRLQLANKERSE 366
Query: 736 ALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAEC 795
AL+ QLE + ++ + K +LAE+ ++ E Q RL+E Q E
Sbjct: 367 ALRRQQLE-----------QQQRENEEHKRQLLAERQKRI--EEQKEQRRRLEEQQRREK 413
Query: 796 QALRLQLQQEMELLNAYQSKIKMQTE---AQHE------------RELQKLEQRVSLRRA 840
+ L+ QQE E Y+ +++ + E A+HE R+L+ L+Q++ +A
Sbjct: 414 E---LRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQA 470
Query: 841 HL----EQKIEEELAA------LQKERSERIKNLLERQER 870
L +++EE+ A L++ER + +RQE+
Sbjct: 471 LLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQ 510
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 233 bits (595), Expect = 5e-61
Identities = 168/524 (32%), Positives = 260/524 (49%), Gaps = 61/524 (11%)
Query: 13 DLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKE 72
DL DP +F + +G+G++G VY + T ++ AIK M +G + E I +E
Sbjct: 14 DLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEE----IKQE 69
Query: 73 VKFLRQLKHPNTIE-YKGCYLKEHTA------WLVMEYC-LGSASDLLEVHK-KPLQEVE 123
+ L++ H I Y G ++K++ WLVME+C GS +DL++ K L+E
Sbjct: 70 INMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEW 129
Query: 124 IAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPA----NSFV 179
IA I L GL++LH H +IHRDIK N+LLTE +VKL DFG ++ N+F+
Sbjct: 130 IAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFI 189
Query: 180 GTPYWMAPEVILAMDEGQ---YDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQN 236
GTPYWMAPEVI A DE YD K D+WSLGIT IE+AE PPL +M+ M AL+ I +N
Sbjct: 190 GTPYWMAPEVI-ACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN 248
Query: 237 DSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVR---RDRPLRV-LIDLIQR 292
+P L+S +W+ F+ F++ CL K +RP + +L++H F+R +R +R+ L D I R
Sbjct: 249 PAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDR 308
Query: 293 TKDAVRELDNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPS 352
TK E D +Y +E +E+E DS +S+
Sbjct: 309 TKKKRGEKDETEYEYSG------------SEEEEEENDSGEPSSILNLPGESTLRRDFLR 356
Query: 353 MSVSTGSQSSSVNSMQEVMDESSSELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDP 412
+ ++ +S ++ Q + +E H + + +K+ R
Sbjct: 357 LQLANKERSEALRRQQLEQQQRENE---EHKRQLLAERQKRIEEQKEQ---RRRLEEQQR 410
Query: 413 RPEPRPTQSVQSQALHY-----RNRERFATIKSASLVTRQIHEHEQENELREQ------- 460
R + Q + Q HY R ER + RQ+ E +++ E+ +Q
Sbjct: 411 REKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQA 470
Query: 461 -MSGYKRMRRQHQKQLIALENKLKAEMD-----EHRLKLQKEVE 498
+ YKR + + Q+Q L+ +LK E D +H+ + Q+ VE
Sbjct: 471 LLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVE 514
Score = 54.7 bits (130), Expect = 4e-07
Identities = 45/211 (21%), Positives = 102/211 (48%), Gaps = 12/211 (5%)
Query: 622 KRHEVEQQNIREELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQT 681
++ E E + E ++ ++L EST ++ +L K R + +R Q
Sbjct: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLE 374
Query: 682 ELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQ 741
+ + + E +KR+ +K + E ++Q + L+ + + K+ + + Q + Y+ +
Sbjct: 375 QQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRRE 434
Query: 742 LEVTPKNEHKTILKTLKDEQTRKLAILAEQ--YEQSINEMMASQALRLDEAQEAECQALR 799
E + ++ +E+ R+L IL +Q +EQ++ ++ + +L+E ++AE L+
Sbjct: 435 EERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQAL--LLEYKRKQLEEQRQAE--RLQ 490
Query: 800 LQLQQEMELLNAYQSKIKMQTEAQHERELQK 830
QL+QE + L + +Q + Q +R ++K
Sbjct: 491 RQLKQERDYL------VSLQHQRQEQRPVEK 515
Score = 49.7 bits (117), Expect = 1e-05
Identities = 47/253 (18%), Positives = 121/253 (47%), Gaps = 14/253 (5%)
Query: 416 PRPTQSVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQL 475
P Q ++ + + ER I+ + R + +++E + SG + ++
Sbjct: 278 PATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGE 337
Query: 476 IALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQ 535
+ L E R L+ ++ + ++ ++L ++Q E + ++ A +K+ ++
Sbjct: 338 PSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEE 397
Query: 536 QILAQQKKDLTTFLESQKKQYKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAE 595
Q +Q++ L E Q+++ ++ K++ +E+ ++E++ R ++H++ Q E
Sbjct: 398 Q--KEQRRRLE---EQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLE 452
Query: 596 EEAHLL--TQQRLYYDKNCRFFKRKIMIKRHEVEQQNIREELNKKRTQKEMEHAMLIRHD 653
EE L QQ+L +++ + KR ++E+Q E L +++ ++E ++ + ++H
Sbjct: 453 EEQRQLEILQQQLLHEQ-----ALLLEYKRKQLEEQRQAERL-QRQLKQERDYLVSLQHQ 506
Query: 654 -ESTRELEYRQLH 665
+ R +E + L+
Sbjct: 507 RQEQRPVEKKPLY 519
Score = 48.9 bits (115), Expect = 2e-05
Identities = 64/291 (21%), Positives = 131/291 (45%), Gaps = 40/291 (13%)
Query: 439 KSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQLIALENKLKAEMDEHRLKLQKEVE 498
K S + + ++ + EQ+ + +R Q ++ + ++ LK +D + K ++ E
Sbjct: 261 KFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQ--LKDHIDRTKKKRGEKDE 318
Query: 499 THANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQQILAQQKKDLTTFLESQKKQYKI 558
T S E E+ E + + E ++ L Q L ++++ +
Sbjct: 319 TEYEYSGSEEEEEENDSG---EPSSILNLPGESTLRRDFLRLQ-------LANKERSEAL 368
Query: 559 CKEKIKEEMNEDHSTPKK---EKQERISKHKENLQHTQAEE--EAHLLTQQ----RLYYD 609
+++++++ E+ ++ E+Q+RI + KE + + ++ E L QQ R +Y+
Sbjct: 369 RRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYE 428
Query: 610 KNCRFFKRKIMIKRHEVEQQNIREELNKKRTQKEM-------EHAMLIRHDESTRELEYR 662
+ R R+ +R E EQ+ IR +L +++ Q E+ E A+L+ + E E R
Sbjct: 429 EQMR---REEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLE-EQR 484
Query: 663 QLHTLQKL----RMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQP 709
Q LQ+ R L+ LQHQ + + +E ++ H K M ++P
Sbjct: 485 QAERLQRQLKQERDYLVSLQHQRQEQRPVE----KKPLYHYKEGMSPSEKP 531
Score = 42.7 bits (99), Expect = 0.002
Identities = 42/197 (21%), Positives = 88/197 (44%), Gaps = 9/197 (4%)
Query: 689 YNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKV-----QTKQYKALKNHQLE 743
+++R E KH +R QP N + + +Q+K T K +T+ + + E
Sbjct: 274 HSQRPATEQLMKHPF-IRDQP-NERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEE 331
Query: 744 VTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQLQ 803
E +IL + R+ + + + +E + Q L + +E E +L +
Sbjct: 332 ENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLE-QQQRENEEHKRQLLAE 390
Query: 804 QEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKN 863
++ + + + +++ + + E+EL+K ++R RR + EQ EE + E I+
Sbjct: 391 RQKRIEEQKEQRRRLEEQQRREKELRKQQER-EQRRHYEEQMRREEERRRAEHEQEYIRR 449
Query: 864 LLERQEREIETFDMESL 880
LE ++R++E + L
Sbjct: 450 QLEEEQRQLEILQQQLL 466
Score = 41.6 bits (96), Expect = 0.003
Identities = 56/237 (23%), Positives = 96/237 (40%), Gaps = 42/237 (17%)
Query: 633 EELNKKRTQK---EMEHAMLIRHDESTRELEYRQLHTL---QKLRMDLIRLQHQTELENQ 686
+ KKR +K E E++ +E E + L LR D +RLQ
Sbjct: 307 DRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA------ 360
Query: 687 LEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQLEVTP 746
NK R L R+ +L QQ + + + Q+ + Q + Q +Q + L
Sbjct: 361 ---NKERSEALRRQ---QLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRL--------- 405
Query: 747 KNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQA--LRLQLQQ 804
+EQ R+ L +Q E+ Q R +E + AE + +R QL++
Sbjct: 406 ------------EEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEE 453
Query: 805 EMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEE-LAALQKERSER 860
E L Q ++ + E + ++LE++ R + K E + L +LQ +R E+
Sbjct: 454 EQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQ 510
Score = 38.5 bits (88), Expect = 0.028
Identities = 59/280 (21%), Positives = 118/280 (42%), Gaps = 48/280 (17%)
Query: 618 KIMIKRHEVEQQNIREELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRL 677
++ K+ + Q+ E K + L++H + RQ+ K +D +
Sbjct: 252 RLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKK 311
Query: 678 QHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAM--EMQIKKQFQDTCKVQTKQYK 735
+ + E + EY+ E E +P ++ + E +++ F ++ +
Sbjct: 312 KRGEKDETEYEYSGSEEEEEENDS-----GEPSSILNLPGESTLRRDFLRLQLANKERSE 366
Query: 736 ALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAEC 795
AL+ QLE + ++ + K +LAE+ ++ E Q RL+E Q E
Sbjct: 367 ALRRQQLE-----------QQQRENEEHKRQLLAERQKRI--EEQKEQRRRLEEQQRREK 413
Query: 796 QALRLQLQQEMELLNAYQSKIKMQTE---AQHE------------RELQKLEQRVSLRRA 840
+ L+ QQE E Y+ +++ + E A+HE R+L+ L+Q++ +A
Sbjct: 414 E---LRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQA 470
Query: 841 HL----EQKIEEELAA------LQKERSERIKNLLERQER 870
L +++EE+ A L++ER + +RQE+
Sbjct: 471 LLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQ 510
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 233 bits (595), Expect = 5e-61
Identities = 168/524 (32%), Positives = 260/524 (49%), Gaps = 61/524 (11%)
Query: 13 DLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKE 72
DL DP +F + +G+G++G VY + T ++ AIK M +G + E I +E
Sbjct: 14 DLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEE----IKQE 69
Query: 73 VKFLRQLKHPNTIE-YKGCYLKEHTA------WLVMEYC-LGSASDLLEVHK-KPLQEVE 123
+ L++ H I Y G ++K++ WLVME+C GS +DL++ K L+E
Sbjct: 70 INMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEW 129
Query: 124 IAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPA----NSFV 179
IA I L GL++LH H +IHRDIK N+LLTE +VKL DFG ++ N+F+
Sbjct: 130 IAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFI 189
Query: 180 GTPYWMAPEVILAMDEGQ---YDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQN 236
GTPYWMAPEVI A DE YD K D+WSLGIT IE+AE PPL +M+ M AL+ I +N
Sbjct: 190 GTPYWMAPEVI-ACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN 248
Query: 237 DSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVR---RDRPLRV-LIDLIQR 292
+P L+S +W+ F+ F++ CL K +RP + +L++H F+R +R +R+ L D I R
Sbjct: 249 PAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDR 308
Query: 293 TKDAVRELDNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPS 352
TK E D +Y +E +E+E DS +S+
Sbjct: 309 TKKKRGEKDETEYEYSG------------SEEEEEENDSGEPSSILNLPGESTLRRDFLR 356
Query: 353 MSVSTGSQSSSVNSMQEVMDESSSELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDP 412
+ ++ +S ++ Q + +E H + + +K+ R
Sbjct: 357 LQLANKERSEALRRQQLEQQQRENE---EHKRQLLAERQKRIEEQKEQ---RRRLEEQQR 410
Query: 413 RPEPRPTQSVQSQALHY-----RNRERFATIKSASLVTRQIHEHEQENELREQ------- 460
R + Q + Q HY R ER + RQ+ E +++ E+ +Q
Sbjct: 411 REKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQA 470
Query: 461 -MSGYKRMRRQHQKQLIALENKLKAEMD-----EHRLKLQKEVE 498
+ YKR + + Q+Q L+ +LK E D +H+ + Q+ VE
Sbjct: 471 LLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVE 514
Score = 54.7 bits (130), Expect = 4e-07
Identities = 45/211 (21%), Positives = 102/211 (48%), Gaps = 12/211 (5%)
Query: 622 KRHEVEQQNIREELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQT 681
++ E E + E ++ ++L EST ++ +L K R + +R Q
Sbjct: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLE 374
Query: 682 ELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQ 741
+ + + E +KR+ +K + E ++Q + L+ + + K+ + + Q + Y+ +
Sbjct: 375 QQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRRE 434
Query: 742 LEVTPKNEHKTILKTLKDEQTRKLAILAEQ--YEQSINEMMASQALRLDEAQEAECQALR 799
E + ++ +E+ R+L IL +Q +EQ++ ++ + +L+E ++AE L+
Sbjct: 435 EERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQAL--LLEYKRKQLEEQRQAE--RLQ 490
Query: 800 LQLQQEMELLNAYQSKIKMQTEAQHERELQK 830
QL+QE + L + +Q + Q +R ++K
Sbjct: 491 RQLKQERDYL------VSLQHQRQEQRPVEK 515
Score = 51.2 bits (121), Expect = 4e-06
Identities = 97/455 (21%), Positives = 193/455 (42%), Gaps = 54/455 (11%)
Query: 439 KSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQLIALENKLKAEMDEHRLKLQKEVE 498
K S + + ++ + EQ+ + +R Q ++ + ++ LK +D + K ++ E
Sbjct: 261 KFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQ--LKDHIDRTKKKRGEKDE 318
Query: 499 THANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQQILAQQKKDLTTFLESQKKQYKI 558
T S E E+ E + + E ++ L Q L ++++ +
Sbjct: 319 TEYEYSGSEEEEEENDSG---EPSSILNLPGESTLRRDFLRLQ-------LANKERSEAL 368
Query: 559 CKEKIKEEMNEDHSTPKK---EKQERISKHKENLQHTQAEE--EAHLLTQQ----RLYYD 609
+++++++ E+ ++ E+Q+RI + KE + + ++ E L QQ R +Y+
Sbjct: 369 RRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYE 428
Query: 610 KNCRFFKRKIMIKRHEVEQQNIREELNKKRTQKEM-------EHAMLIRHDESTRELEYR 662
+ R R+ +R E EQ+ IR +L +++ Q E+ E A+L+ + E E R
Sbjct: 429 EQMR---REEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLE-EQR 484
Query: 663 QLHTLQKL----RMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQ 718
Q LQ+ R L+ LQHQ + + +E ++ H K M ++P K +E +
Sbjct: 485 QAERLQRQLKQERDYLVSLQHQRQEQRPVE----KKPLYHYKEGMSPSEKPAWAKEVEER 540
Query: 719 IKKQFQDTCKVQTKQYKALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINE 778
+ Q + + K + + L P++E +I Q + + + I
Sbjct: 541 SRLNRQSSPAMPHKVANRISDPNL--PPRSESFSI----SGVQPARTPPMLRPVDPQIPH 594
Query: 779 MMA--SQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKM-QTEAQHERELQKLEQRV 835
++A SQ L +Q Q + L E LN +++M + + E L R+
Sbjct: 595 LVAVKSQGPALTASQSVHEQPTK-GLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRI 653
Query: 836 SL--RRAHLEQKIEEELAALQKERSERIKNLLERQ 868
R + L Q EE++ +R+ I L R+
Sbjct: 654 EKFDRSSWLRQ--EEDIPPKVPQRTTSISPALARK 686
Score = 49.7 bits (117), Expect = 1e-05
Identities = 47/253 (18%), Positives = 121/253 (47%), Gaps = 14/253 (5%)
Query: 416 PRPTQSVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQL 475
P Q ++ + + ER I+ + R + +++E + SG + ++
Sbjct: 278 PATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGE 337
Query: 476 IALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQ 535
+ L E R L+ ++ + ++ ++L ++Q E + ++ A +K+ ++
Sbjct: 338 PSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEE 397
Query: 536 QILAQQKKDLTTFLESQKKQYKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAE 595
Q +Q++ L E Q+++ ++ K++ +E+ ++E++ R ++H++ Q E
Sbjct: 398 Q--KEQRRRLE---EQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLE 452
Query: 596 EEAHLL--TQQRLYYDKNCRFFKRKIMIKRHEVEQQNIREELNKKRTQKEMEHAMLIRHD 653
EE L QQ+L +++ + KR ++E+Q E L +++ ++E ++ + ++H
Sbjct: 453 EEQRQLEILQQQLLHEQ-----ALLLEYKRKQLEEQRQAERL-QRQLKQERDYLVSLQHQ 506
Query: 654 -ESTRELEYRQLH 665
+ R +E + L+
Sbjct: 507 RQEQRPVEKKPLY 519
Score = 42.7 bits (99), Expect = 0.002
Identities = 42/197 (21%), Positives = 88/197 (44%), Gaps = 9/197 (4%)
Query: 689 YNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKV-----QTKQYKALKNHQLE 743
+++R E KH +R QP N + + +Q+K T K +T+ + + E
Sbjct: 274 HSQRPATEQLMKHPF-IRDQP-NERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEE 331
Query: 744 VTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQLQ 803
E +IL + R+ + + + +E + Q L + +E E +L +
Sbjct: 332 ENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLE-QQQRENEEHKRQLLAE 390
Query: 804 QEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKN 863
++ + + + +++ + + E+EL+K ++R RR + EQ EE + E I+
Sbjct: 391 RQKRIEEQKEQRRRLEEQQRREKELRKQQER-EQRRHYEEQMRREEERRRAEHEQEYIRR 449
Query: 864 LLERQEREIETFDMESL 880
LE ++R++E + L
Sbjct: 450 QLEEEQRQLEILQQQLL 466
Score = 38.5 bits (88), Expect = 0.028
Identities = 59/280 (21%), Positives = 118/280 (42%), Gaps = 48/280 (17%)
Query: 618 KIMIKRHEVEQQNIREELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRL 677
++ K+ + Q+ E K + L++H + RQ+ K +D +
Sbjct: 252 RLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKK 311
Query: 678 QHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAM--EMQIKKQFQDTCKVQTKQYK 735
+ + E + EY+ E E +P ++ + E +++ F ++ +
Sbjct: 312 KRGEKDETEYEYSGSEEEEEENDS-----GEPSSILNLPGESTLRRDFLRLQLANKERSE 366
Query: 736 ALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAEC 795
AL+ QLE + ++ + K +LAE+ ++ E Q RL+E Q E
Sbjct: 367 ALRRQQLE-----------QQQRENEEHKRQLLAERQKRI--EEQKEQRRRLEEQQRREK 413
Query: 796 QALRLQLQQEMELLNAYQSKIKMQTE---AQHE------------RELQKLEQRVSLRRA 840
+ L+ QQE E Y+ +++ + E A+HE R+L+ L+Q++ +A
Sbjct: 414 E---LRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQA 470
Query: 841 HL----EQKIEEELAA------LQKERSERIKNLLERQER 870
L +++EE+ A L++ER + +RQE+
Sbjct: 471 LLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQ 510
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 233 bits (595), Expect = 5e-61
Identities = 168/524 (32%), Positives = 260/524 (49%), Gaps = 61/524 (11%)
Query: 13 DLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKE 72
DL DP +F + +G+G++G VY + T ++ AIK M +G + E I +E
Sbjct: 14 DLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEE----IKQE 69
Query: 73 VKFLRQLKHPNTIE-YKGCYLKEHTA------WLVMEYC-LGSASDLLEVHK-KPLQEVE 123
+ L++ H I Y G ++K++ WLVME+C GS +DL++ K L+E
Sbjct: 70 INMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEW 129
Query: 124 IAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPA----NSFV 179
IA I L GL++LH H +IHRDIK N+LLTE +VKL DFG ++ N+F+
Sbjct: 130 IAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFI 189
Query: 180 GTPYWMAPEVILAMDEGQ---YDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQN 236
GTPYWMAPEVI A DE YD K D+WSLGIT IE+AE PPL +M+ M AL+ I +N
Sbjct: 190 GTPYWMAPEVI-ACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN 248
Query: 237 DSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVR---RDRPLRV-LIDLIQR 292
+P L+S +W+ F+ F++ CL K +RP + +L++H F+R +R +R+ L D I R
Sbjct: 249 PAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDR 308
Query: 293 TKDAVRELDNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPS 352
TK E D +Y +E +E+E DS +S+
Sbjct: 309 TKKKRGEKDETEYEYSG------------SEEEEEENDSGEPSSILNLPGESTLRRDFLR 356
Query: 353 MSVSTGSQSSSVNSMQEVMDESSSELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDP 412
+ ++ +S ++ Q + +E H + + +K+ R
Sbjct: 357 LQLANKERSEALRRQQLEQQQRENE---EHKRQLLAERQKRIEEQKEQ---RRRLEEQQR 410
Query: 413 RPEPRPTQSVQSQALHY-----RNRERFATIKSASLVTRQIHEHEQENELREQ------- 460
R + Q + Q HY R ER + RQ+ E +++ E+ +Q
Sbjct: 411 REKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQA 470
Query: 461 -MSGYKRMRRQHQKQLIALENKLKAEMD-----EHRLKLQKEVE 498
+ YKR + + Q+Q L+ +LK E D +H+ + Q+ VE
Sbjct: 471 LLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVE 514
Score = 54.7 bits (130), Expect = 4e-07
Identities = 45/211 (21%), Positives = 102/211 (48%), Gaps = 12/211 (5%)
Query: 622 KRHEVEQQNIREELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQT 681
++ E E + E ++ ++L EST ++ +L K R + +R Q
Sbjct: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLE 374
Query: 682 ELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQ 741
+ + + E +KR+ +K + E ++Q + L+ + + K+ + + Q + Y+ +
Sbjct: 375 QQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRRE 434
Query: 742 LEVTPKNEHKTILKTLKDEQTRKLAILAEQ--YEQSINEMMASQALRLDEAQEAECQALR 799
E + ++ +E+ R+L IL +Q +EQ++ ++ + +L+E ++AE L+
Sbjct: 435 EERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQAL--LLEYKRKQLEEQRQAE--RLQ 490
Query: 800 LQLQQEMELLNAYQSKIKMQTEAQHERELQK 830
QL+QE + L + +Q + Q +R ++K
Sbjct: 491 RQLKQERDYL------VSLQHQRQEQRPVEK 515
Score = 51.2 bits (121), Expect = 4e-06
Identities = 97/455 (21%), Positives = 193/455 (42%), Gaps = 54/455 (11%)
Query: 439 KSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQLIALENKLKAEMDEHRLKLQKEVE 498
K S + + ++ + EQ+ + +R Q ++ + ++ LK +D + K ++ E
Sbjct: 261 KFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQ--LKDHIDRTKKKRGEKDE 318
Query: 499 THANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQQILAQQKKDLTTFLESQKKQYKI 558
T S E E+ E + + E ++ L Q L ++++ +
Sbjct: 319 TEYEYSGSEEEEEENDSG---EPSSILNLPGESTLRRDFLRLQ-------LANKERSEAL 368
Query: 559 CKEKIKEEMNEDHSTPKK---EKQERISKHKENLQHTQAEE--EAHLLTQQ----RLYYD 609
+++++++ E+ ++ E+Q+RI + KE + + ++ E L QQ R +Y+
Sbjct: 369 RRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYE 428
Query: 610 KNCRFFKRKIMIKRHEVEQQNIREELNKKRTQKEM-------EHAMLIRHDESTRELEYR 662
+ R R+ +R E EQ+ IR +L +++ Q E+ E A+L+ + E E R
Sbjct: 429 EQMR---REEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLE-EQR 484
Query: 663 QLHTLQKL----RMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQ 718
Q LQ+ R L+ LQHQ + + +E ++ H K M ++P K +E +
Sbjct: 485 QAERLQRQLKQERDYLVSLQHQRQEQRPVE----KKPLYHYKEGMSPSEKPAWAKEVEER 540
Query: 719 IKKQFQDTCKVQTKQYKALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINE 778
+ Q + + K + + L P++E +I Q + + + I
Sbjct: 541 SRLNRQSSPAMPHKVANRISDPNL--PPRSESFSI----SGVQPARTPPMLRPVDPQIPH 594
Query: 779 MMA--SQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKM-QTEAQHERELQKLEQRV 835
++A SQ L +Q Q + L E LN +++M + + E L R+
Sbjct: 595 LVAVKSQGPALTASQSVHEQPTK-GLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRI 653
Query: 836 SL--RRAHLEQKIEEELAALQKERSERIKNLLERQ 868
R + L Q EE++ +R+ I L R+
Sbjct: 654 EKFDRSSWLRQ--EEDIPPKVPQRTTSISPALARK 686
Score = 49.7 bits (117), Expect = 1e-05
Identities = 47/253 (18%), Positives = 121/253 (47%), Gaps = 14/253 (5%)
Query: 416 PRPTQSVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQL 475
P Q ++ + + ER I+ + R + +++E + SG + ++
Sbjct: 278 PATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGE 337
Query: 476 IALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQ 535
+ L E R L+ ++ + ++ ++L ++Q E + ++ A +K+ ++
Sbjct: 338 PSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEE 397
Query: 536 QILAQQKKDLTTFLESQKKQYKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAE 595
Q +Q++ L E Q+++ ++ K++ +E+ ++E++ R ++H++ Q E
Sbjct: 398 Q--KEQRRRLE---EQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLE 452
Query: 596 EEAHLL--TQQRLYYDKNCRFFKRKIMIKRHEVEQQNIREELNKKRTQKEMEHAMLIRHD 653
EE L QQ+L +++ + KR ++E+Q E L +++ ++E ++ + ++H
Sbjct: 453 EEQRQLEILQQQLLHEQ-----ALLLEYKRKQLEEQRQAERL-QRQLKQERDYLVSLQHQ 506
Query: 654 -ESTRELEYRQLH 665
+ R +E + L+
Sbjct: 507 RQEQRPVEKKPLY 519
Score = 42.7 bits (99), Expect = 0.002
Identities = 42/197 (21%), Positives = 88/197 (44%), Gaps = 9/197 (4%)
Query: 689 YNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKV-----QTKQYKALKNHQLE 743
+++R E KH +R QP N + + +Q+K T K +T+ + + E
Sbjct: 274 HSQRPATEQLMKHPF-IRDQP-NERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEE 331
Query: 744 VTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQLQ 803
E +IL + R+ + + + +E + Q L + +E E +L +
Sbjct: 332 ENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLE-QQQRENEEHKRQLLAE 390
Query: 804 QEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKN 863
++ + + + +++ + + E+EL+K ++R RR + EQ EE + E I+
Sbjct: 391 RQKRIEEQKEQRRRLEEQQRREKELRKQQER-EQRRHYEEQMRREEERRRAEHEQEYIRR 449
Query: 864 LLERQEREIETFDMESL 880
LE ++R++E + L
Sbjct: 450 QLEEEQRQLEILQQQLL 466
Score = 38.5 bits (88), Expect = 0.028
Identities = 59/280 (21%), Positives = 118/280 (42%), Gaps = 48/280 (17%)
Query: 618 KIMIKRHEVEQQNIREELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRL 677
++ K+ + Q+ E K + L++H + RQ+ K +D +
Sbjct: 252 RLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKK 311
Query: 678 QHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAM--EMQIKKQFQDTCKVQTKQYK 735
+ + E + EY+ E E +P ++ + E +++ F ++ +
Sbjct: 312 KRGEKDETEYEYSGSEEEEEENDS-----GEPSSILNLPGESTLRRDFLRLQLANKERSE 366
Query: 736 ALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAEC 795
AL+ QLE + ++ + K +LAE+ ++ E Q RL+E Q E
Sbjct: 367 ALRRQQLE-----------QQQRENEEHKRQLLAERQKRI--EEQKEQRRRLEEQQRREK 413
Query: 796 QALRLQLQQEMELLNAYQSKIKMQTE---AQHE------------RELQKLEQRVSLRRA 840
+ L+ QQE E Y+ +++ + E A+HE R+L+ L+Q++ +A
Sbjct: 414 E---LRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQA 470
Query: 841 HL----EQKIEEELAA------LQKERSERIKNLLERQER 870
L +++EE+ A L++ER + +RQE+
Sbjct: 471 LLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQ 510
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 229 bits (584), Expect = 9e-60
Identities = 134/284 (47%), Positives = 175/284 (61%), Gaps = 14/284 (4%)
Query: 17 KDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKEVKFL 76
K DPEELF L +IG GSFG V+ + T +VVAIK + ++ ++ +DI +E+ L
Sbjct: 17 KADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDL--EEAEDEIEDIQQEITVL 74
Query: 77 RQLKHPNTIEYKGCYLKEHTAWLVMEYCLG-SASDLLEVHKKPLQEVEIAAITHGALHGL 135
Q P +Y G YLK+ W++MEY G SA DLLE PL E +IA I L GL
Sbjct: 75 SQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE--PGPLDETQIATILREILKGL 132
Query: 136 AYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPA----NSFVGTPYWMAPEVIL 191
YLHS IHRDIKA N+LL+E G+VKLADFG A + N+FVGTP+WMAPEVI
Sbjct: 133 DYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI- 191
Query: 192 AMDEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQSNEWTDSFR 251
+ YD K DIWSLGIT IELA +PP ++ M L+ I +N+ PTL+ N ++ +
Sbjct: 192 --KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN-YSKPLK 248
Query: 252 RFVDYCLQKIPQERPTSAELLRHDFVRRD-RPLRVLIDLIQRTK 294
FV+ CL K P RPT+ ELL+H F+ R+ + L +LI R K
Sbjct: 249 EFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYK 292
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 229 bits (584), Expect = 9e-60
Identities = 134/284 (47%), Positives = 175/284 (61%), Gaps = 14/284 (4%)
Query: 17 KDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKEVKFL 76
K DPEELF L +IG GSFG V+ + T +VVAIK + ++ ++ +DI +E+ L
Sbjct: 29 KADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDL--EEAEDEIEDIQQEITVL 86
Query: 77 RQLKHPNTIEYKGCYLKEHTAWLVMEYCLG-SASDLLEVHKKPLQEVEIAAITHGALHGL 135
Q P +Y G YLK+ W++MEY G SA DLLE PL E +IA I L GL
Sbjct: 87 SQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE--PGPLDETQIATILREILKGL 144
Query: 136 AYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPA----NSFVGTPYWMAPEVIL 191
YLHS IHRDIKA N+LL+E G+VKLADFG A + N+FVGTP+WMAPEVI
Sbjct: 145 DYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI- 203
Query: 192 AMDEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQSNEWTDSFR 251
+ YD K DIWSLGIT IELA +PP ++ M L+ I +N+ PTL+ N ++ +
Sbjct: 204 --KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN-YSKPLK 260
Query: 252 RFVDYCLQKIPQERPTSAELLRHDFVRRD-RPLRVLIDLIQRTK 294
FV+ CL K P RPT+ ELL+H F+ R+ + L +LI R K
Sbjct: 261 EFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYK 304
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 229 bits (583), Expect = 1e-59
Identities = 167/511 (32%), Positives = 253/511 (49%), Gaps = 64/511 (12%)
Query: 13 DLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKE 72
DL DP +F + +G+G++G VY + T ++ AIK M +G + E I +E
Sbjct: 14 DLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEE----IKQE 69
Query: 73 VKFLRQLKHPNTIE-YKGCYLKEHTA------WLVMEYC-LGSASDLLEVHK-KPLQEVE 123
+ L++ H I Y G ++K++ WLVME+C GS +DL++ K L+E
Sbjct: 70 INMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEW 129
Query: 124 IAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPA----NSFV 179
IA I L GL++LH H +IHRDIK N+LLTE +VKL DFG ++ N+F+
Sbjct: 130 IAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFI 189
Query: 180 GTPYWMAPEVILAMDEGQ---YDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQN 236
GTPYWMAPEVI A DE YD K D+WSLGIT IE+AE PPL +M+ M AL+ I +N
Sbjct: 190 GTPYWMAPEVI-ACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN 248
Query: 237 DSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVR---RDRPLRV-LIDLIQR 292
+P L+S +W+ F+ F++ CL K +RP + +L++H F+R +R +R+ L D I R
Sbjct: 249 PAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDR 308
Query: 293 TKDAVRELDNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPS 352
TK E D +Y +E +E+E DS +S+
Sbjct: 309 TKKKRGEKDETEYEYSG------------SEEEEEENDSGEPSSILNLPGESTLRRDFLR 356
Query: 353 MSVSTGSQSSSVNSMQEVMDESSSELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDP 412
+ ++ +S ++ Q + +E H + + +K+ R
Sbjct: 357 LQLANKERSEALRRQQLEQQQRENE---EHKRQLLAERQKRIEEQKEQ---RRRLEEQQR 410
Query: 413 RPEPRPTQSVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQ 472
R + Q + Q HY + R R+ EHEQE YKR + + Q
Sbjct: 411 REKELRKQQEREQRRHYEEQMRREE-------ERRRAEHEQE---------YKRKQLEEQ 454
Query: 473 KQLIALENKLKAEMD-----EHRLKLQKEVE 498
+Q L+ +LK E D +H+ + Q+ VE
Sbjct: 455 RQAERLQRQLKQERDYLVSLQHQRQEQRPVE 485
Score = 46.2 bits (108), Expect = 1e-04
Identities = 52/251 (20%), Positives = 110/251 (43%), Gaps = 29/251 (11%)
Query: 618 KIMIKRHEVEQQNIREELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRL 677
++ K+ + Q+ E K + L++H + RQ+ K +D +
Sbjct: 252 RLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKK 311
Query: 678 QHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAM--EMQIKKQFQDTCKVQTKQYK 735
+ + E + EY+ E E +P ++ + E +++ F ++ +
Sbjct: 312 KRGEKDETEYEYSGSEEEEEENDS-----GEPSSILNLPGESTLRRDFLRLQLANKERSE 366
Query: 736 ALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAEC 795
AL+ QLE + ++ + K +LAE+ ++ E Q RL+E Q E
Sbjct: 367 ALRRQQLE-----------QQQRENEEHKRQLLAERQKRI--EEQKEQRRRLEEQQRREK 413
Query: 796 QALRLQLQQEMELLNAYQSKIKMQTE---AQHERELQKLEQRVSLRRAHLEQKIEEE--- 849
+ L+ QQE E Y+ +++ + E A+HE+E ++ + + L++++++E
Sbjct: 414 E---LRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDY 470
Query: 850 LAALQKERSER 860
L +LQ +R E+
Sbjct: 471 LVSLQHQRQEQ 481
Score = 40.4 bits (93), Expect = 0.007
Identities = 33/190 (17%), Positives = 87/190 (45%), Gaps = 5/190 (2%)
Query: 416 PRPTQSVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQL 475
P Q ++ + + ER I+ + R + +++E + SG + ++
Sbjct: 278 PATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGE 337
Query: 476 IALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQ 535
+ L E R L+ ++ + ++ ++L ++Q E + ++ A +K+ ++
Sbjct: 338 PSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEE 397
Query: 536 QILAQQKKDLTTFLESQKKQYKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAE 595
Q +Q++ L E Q+++ ++ K++ +E+ ++E++ R ++H++ + Q E
Sbjct: 398 Q--KEQRRRLE---EQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLE 452
Query: 596 EEAHLLTQQR 605
E+ QR
Sbjct: 453 EQRQAERLQR 462
Score = 39.3 bits (90), Expect = 0.017
Identities = 38/188 (20%), Positives = 84/188 (44%), Gaps = 8/188 (4%)
Query: 689 YNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKV-----QTKQYKALKNHQLE 743
+++R E KH +R QP N + + +Q+K T K +T+ + + E
Sbjct: 274 HSQRPATEQLMKHPF-IRDQP-NERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEE 331
Query: 744 VTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQLQ 803
E +IL + R+ + + + +E + Q L + +E E +L +
Sbjct: 332 ENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLE-QQQRENEEHKRQLLAE 390
Query: 804 QEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKN 863
++ + + + +++ + + E+EL+K ++R R + + EEE + E+ + K
Sbjct: 391 RQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQ 450
Query: 864 LLERQERE 871
L E+++ E
Sbjct: 451 LEEQRQAE 458
Score = 33.9 bits (76), Expect = 0.70
Identities = 30/112 (26%), Positives = 54/112 (48%), Gaps = 8/112 (7%)
Query: 769 AEQYEQSINEMMASQALRLDEAQEAECQALRLQL--QQEMELLNAYQSKIKMQTEAQHER 826
+E+ E+ + S L L LRLQL ++ E L Q + + + +H+R
Sbjct: 326 SEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKR 385
Query: 827 EL-----QKLEQRVSLRRAHLEQKIEEELAALQKERSERIKNLLERQEREIE 873
+L +++E++ RR EQ+ E+ Q+ER +R ++ E+ RE E
Sbjct: 386 QLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQR-RHYEEQMRREEE 436
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 229 bits (583), Expect = 1e-59
Identities = 167/511 (32%), Positives = 253/511 (49%), Gaps = 64/511 (12%)
Query: 13 DLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKE 72
DL DP +F + +G+G++G VY + T ++ AIK M +G + E I +E
Sbjct: 14 DLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEE----IKQE 69
Query: 73 VKFLRQLKHPNTIE-YKGCYLKEHTA------WLVMEYC-LGSASDLLEVHK-KPLQEVE 123
+ L++ H I Y G ++K++ WLVME+C GS +DL++ K L+E
Sbjct: 70 INMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEW 129
Query: 124 IAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPA----NSFV 179
IA I L GL++LH H +IHRDIK N+LLTE +VKL DFG ++ N+F+
Sbjct: 130 IAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFI 189
Query: 180 GTPYWMAPEVILAMDEGQ---YDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQN 236
GTPYWMAPEVI A DE YD K D+WSLGIT IE+AE PPL +M+ M AL+ I +N
Sbjct: 190 GTPYWMAPEVI-ACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN 248
Query: 237 DSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVR---RDRPLRV-LIDLIQR 292
+P L+S +W+ F+ F++ CL K +RP + +L++H F+R +R +R+ L D I R
Sbjct: 249 PAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDR 308
Query: 293 TKDAVRELDNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPS 352
TK E D +Y +E +E+E DS +S+
Sbjct: 309 TKKKRGEKDETEYEYSG------------SEEEEEENDSGEPSSILNLPGESTLRRDFLR 356
Query: 353 MSVSTGSQSSSVNSMQEVMDESSSELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDP 412
+ ++ +S ++ Q + +E H + + +K+ R
Sbjct: 357 LQLANKERSEALRRQQLEQQQRENE---EHKRQLLAERQKRIEEQKEQ---RRRLEEQQR 410
Query: 413 RPEPRPTQSVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQ 472
R + Q + Q HY + R R+ EHEQE YKR + + Q
Sbjct: 411 REKELRKQQEREQRRHYEEQMRREE-------ERRRAEHEQE---------YKRKQLEEQ 454
Query: 473 KQLIALENKLKAEMD-----EHRLKLQKEVE 498
+Q L+ +LK E D +H+ + Q+ VE
Sbjct: 455 RQAERLQRQLKQERDYLVSLQHQRQEQRPVE 485
Score = 46.2 bits (108), Expect = 1e-04
Identities = 52/251 (20%), Positives = 110/251 (43%), Gaps = 29/251 (11%)
Query: 618 KIMIKRHEVEQQNIREELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRL 677
++ K+ + Q+ E K + L++H + RQ+ K +D +
Sbjct: 252 RLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKK 311
Query: 678 QHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAM--EMQIKKQFQDTCKVQTKQYK 735
+ + E + EY+ E E +P ++ + E +++ F ++ +
Sbjct: 312 KRGEKDETEYEYSGSEEEEEENDS-----GEPSSILNLPGESTLRRDFLRLQLANKERSE 366
Query: 736 ALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAEC 795
AL+ QLE + ++ + K +LAE+ ++ E Q RL+E Q E
Sbjct: 367 ALRRQQLE-----------QQQRENEEHKRQLLAERQKRI--EEQKEQRRRLEEQQRREK 413
Query: 796 QALRLQLQQEMELLNAYQSKIKMQTE---AQHERELQKLEQRVSLRRAHLEQKIEEE--- 849
+ L+ QQE E Y+ +++ + E A+HE+E ++ + + L++++++E
Sbjct: 414 E---LRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDY 470
Query: 850 LAALQKERSER 860
L +LQ +R E+
Sbjct: 471 LVSLQHQRQEQ 481
Score = 40.4 bits (93), Expect = 0.007
Identities = 33/190 (17%), Positives = 87/190 (45%), Gaps = 5/190 (2%)
Query: 416 PRPTQSVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQL 475
P Q ++ + + ER I+ + R + +++E + SG + ++
Sbjct: 278 PATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGE 337
Query: 476 IALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQ 535
+ L E R L+ ++ + ++ ++L ++Q E + ++ A +K+ ++
Sbjct: 338 PSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEE 397
Query: 536 QILAQQKKDLTTFLESQKKQYKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAE 595
Q +Q++ L E Q+++ ++ K++ +E+ ++E++ R ++H++ + Q E
Sbjct: 398 Q--KEQRRRLE---EQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLE 452
Query: 596 EEAHLLTQQR 605
E+ QR
Sbjct: 453 EQRQAERLQR 462
Score = 39.3 bits (90), Expect = 0.017
Identities = 38/188 (20%), Positives = 84/188 (44%), Gaps = 8/188 (4%)
Query: 689 YNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKV-----QTKQYKALKNHQLE 743
+++R E KH +R QP N + + +Q+K T K +T+ + + E
Sbjct: 274 HSQRPATEQLMKHPF-IRDQP-NERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEE 331
Query: 744 VTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQLQ 803
E +IL + R+ + + + +E + Q L + +E E +L +
Sbjct: 332 ENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLE-QQQRENEEHKRQLLAE 390
Query: 804 QEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKN 863
++ + + + +++ + + E+EL+K ++R R + + EEE + E+ + K
Sbjct: 391 RQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQ 450
Query: 864 LLERQERE 871
L E+++ E
Sbjct: 451 LEEQRQAE 458
Score = 33.9 bits (76), Expect = 0.70
Identities = 30/112 (26%), Positives = 54/112 (48%), Gaps = 8/112 (7%)
Query: 769 AEQYEQSINEMMASQALRLDEAQEAECQALRLQL--QQEMELLNAYQSKIKMQTEAQHER 826
+E+ E+ + S L L LRLQL ++ E L Q + + + +H+R
Sbjct: 326 SEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKR 385
Query: 827 EL-----QKLEQRVSLRRAHLEQKIEEELAALQKERSERIKNLLERQEREIE 873
+L +++E++ RR EQ+ E+ Q+ER +R ++ E+ RE E
Sbjct: 386 QLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQR-RHYEEQMRREEE 436
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 229 bits (583), Expect = 1e-59
Identities = 167/511 (32%), Positives = 253/511 (49%), Gaps = 64/511 (12%)
Query: 13 DLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKE 72
DL DP +F + +G+G++G VY + T ++ AIK M +G + E I +E
Sbjct: 14 DLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEE----IKQE 69
Query: 73 VKFLRQLKHPNTIE-YKGCYLKEHTA------WLVMEYC-LGSASDLLEVHK-KPLQEVE 123
+ L++ H I Y G ++K++ WLVME+C GS +DL++ K L+E
Sbjct: 70 INMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEW 129
Query: 124 IAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPA----NSFV 179
IA I L GL++LH H +IHRDIK N+LLTE +VKL DFG ++ N+F+
Sbjct: 130 IAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFI 189
Query: 180 GTPYWMAPEVILAMDEGQ---YDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQN 236
GTPYWMAPEVI A DE YD K D+WSLGIT IE+AE PPL +M+ M AL+ I +N
Sbjct: 190 GTPYWMAPEVI-ACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN 248
Query: 237 DSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVR---RDRPLRV-LIDLIQR 292
+P L+S +W+ F+ F++ CL K +RP + +L++H F+R +R +R+ L D I R
Sbjct: 249 PAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDR 308
Query: 293 TKDAVRELDNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPS 352
TK E D +Y +E +E+E DS +S+
Sbjct: 309 TKKKRGEKDETEYEYSG------------SEEEEEENDSGEPSSILNLPGESTLRRDFLR 356
Query: 353 MSVSTGSQSSSVNSMQEVMDESSSELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDP 412
+ ++ +S ++ Q + +E H + + +K+ R
Sbjct: 357 LQLANKERSEALRRQQLEQQQRENE---EHKRQLLAERQKRIEEQKEQ---RRRLEEQQR 410
Query: 413 RPEPRPTQSVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQ 472
R + Q + Q HY + R R+ EHEQE YKR + + Q
Sbjct: 411 REKELRKQQEREQRRHYEEQMRREE-------ERRRAEHEQE---------YKRKQLEEQ 454
Query: 473 KQLIALENKLKAEMD-----EHRLKLQKEVE 498
+Q L+ +LK E D +H+ + Q+ VE
Sbjct: 455 RQAERLQRQLKQERDYLVSLQHQRQEQRPVE 485
Score = 46.2 bits (108), Expect = 1e-04
Identities = 52/251 (20%), Positives = 110/251 (43%), Gaps = 29/251 (11%)
Query: 618 KIMIKRHEVEQQNIREELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRL 677
++ K+ + Q+ E K + L++H + RQ+ K +D +
Sbjct: 252 RLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKK 311
Query: 678 QHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAM--EMQIKKQFQDTCKVQTKQYK 735
+ + E + EY+ E E +P ++ + E +++ F ++ +
Sbjct: 312 KRGEKDETEYEYSGSEEEEEENDS-----GEPSSILNLPGESTLRRDFLRLQLANKERSE 366
Query: 736 ALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAEC 795
AL+ QLE + ++ + K +LAE+ ++ E Q RL+E Q E
Sbjct: 367 ALRRQQLE-----------QQQRENEEHKRQLLAERQKRI--EEQKEQRRRLEEQQRREK 413
Query: 796 QALRLQLQQEMELLNAYQSKIKMQTE---AQHERELQKLEQRVSLRRAHLEQKIEEE--- 849
+ L+ QQE E Y+ +++ + E A+HE+E ++ + + L++++++E
Sbjct: 414 E---LRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDY 470
Query: 850 LAALQKERSER 860
L +LQ +R E+
Sbjct: 471 LVSLQHQRQEQ 481
Score = 40.4 bits (93), Expect = 0.007
Identities = 33/190 (17%), Positives = 87/190 (45%), Gaps = 5/190 (2%)
Query: 416 PRPTQSVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQL 475
P Q ++ + + ER I+ + R + +++E + SG + ++
Sbjct: 278 PATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGE 337
Query: 476 IALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQ 535
+ L E R L+ ++ + ++ ++L ++Q E + ++ A +K+ ++
Sbjct: 338 PSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEE 397
Query: 536 QILAQQKKDLTTFLESQKKQYKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAE 595
Q +Q++ L E Q+++ ++ K++ +E+ ++E++ R ++H++ + Q E
Sbjct: 398 Q--KEQRRRLE---EQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLE 452
Query: 596 EEAHLLTQQR 605
E+ QR
Sbjct: 453 EQRQAERLQR 462
Score = 39.3 bits (90), Expect = 0.017
Identities = 38/188 (20%), Positives = 84/188 (44%), Gaps = 8/188 (4%)
Query: 689 YNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKV-----QTKQYKALKNHQLE 743
+++R E KH +R QP N + + +Q+K T K +T+ + + E
Sbjct: 274 HSQRPATEQLMKHPF-IRDQP-NERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEE 331
Query: 744 VTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQLQ 803
E +IL + R+ + + + +E + Q L + +E E +L +
Sbjct: 332 ENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLE-QQQRENEEHKRQLLAE 390
Query: 804 QEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKN 863
++ + + + +++ + + E+EL+K ++R R + + EEE + E+ + K
Sbjct: 391 RQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQ 450
Query: 864 LLERQERE 871
L E+++ E
Sbjct: 451 LEEQRQAE 458
Score = 33.9 bits (76), Expect = 0.70
Identities = 30/112 (26%), Positives = 54/112 (48%), Gaps = 8/112 (7%)
Query: 769 AEQYEQSINEMMASQALRLDEAQEAECQALRLQL--QQEMELLNAYQSKIKMQTEAQHER 826
+E+ E+ + S L L LRLQL ++ E L Q + + + +H+R
Sbjct: 326 SEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKR 385
Query: 827 EL-----QKLEQRVSLRRAHLEQKIEEELAALQKERSERIKNLLERQEREIE 873
+L +++E++ RR EQ+ E+ Q+ER +R ++ E+ RE E
Sbjct: 386 QLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQR-RHYEEQMRREEE 436
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 229 bits (583), Expect = 1e-59
Identities = 167/511 (32%), Positives = 253/511 (49%), Gaps = 64/511 (12%)
Query: 13 DLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKE 72
DL DP +F + +G+G++G VY + T ++ AIK M +G + E I +E
Sbjct: 14 DLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEE----IKQE 69
Query: 73 VKFLRQLKHPNTIE-YKGCYLKEHTA------WLVMEYC-LGSASDLLEVHK-KPLQEVE 123
+ L++ H I Y G ++K++ WLVME+C GS +DL++ K L+E
Sbjct: 70 INMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEW 129
Query: 124 IAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPA----NSFV 179
IA I L GL++LH H +IHRDIK N+LLTE +VKL DFG ++ N+F+
Sbjct: 130 IAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFI 189
Query: 180 GTPYWMAPEVILAMDEGQ---YDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQN 236
GTPYWMAPEVI A DE YD K D+WSLGIT IE+AE PPL +M+ M AL+ I +N
Sbjct: 190 GTPYWMAPEVI-ACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN 248
Query: 237 DSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVR---RDRPLRV-LIDLIQR 292
+P L+S +W+ F+ F++ CL K +RP + +L++H F+R +R +R+ L D I R
Sbjct: 249 PAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDR 308
Query: 293 TKDAVRELDNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPS 352
TK E D +Y +E +E+E DS +S+
Sbjct: 309 TKKKRGEKDETEYEYSG------------SEEEEEENDSGEPSSILNLPGESTLRRDFLR 356
Query: 353 MSVSTGSQSSSVNSMQEVMDESSSELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDP 412
+ ++ +S ++ Q + +E H + + +K+ R
Sbjct: 357 LQLANKERSEALRRQQLEQQQRENE---EHKRQLLAERQKRIEEQKEQ---RRRLEEQQR 410
Query: 413 RPEPRPTQSVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQ 472
R + Q + Q HY + R R+ EHEQE YKR + + Q
Sbjct: 411 REKELRKQQEREQRRHYEEQMRREE-------ERRRAEHEQE---------YKRKQLEEQ 454
Query: 473 KQLIALENKLKAEMD-----EHRLKLQKEVE 498
+Q L+ +LK E D +H+ + Q+ VE
Sbjct: 455 RQAERLQRQLKQERDYLVSLQHQRQEQRPVE 485
Score = 46.2 bits (108), Expect = 1e-04
Identities = 52/251 (20%), Positives = 110/251 (43%), Gaps = 29/251 (11%)
Query: 618 KIMIKRHEVEQQNIREELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRL 677
++ K+ + Q+ E K + L++H + RQ+ K +D +
Sbjct: 252 RLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKK 311
Query: 678 QHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAM--EMQIKKQFQDTCKVQTKQYK 735
+ + E + EY+ E E +P ++ + E +++ F ++ +
Sbjct: 312 KRGEKDETEYEYSGSEEEEEENDS-----GEPSSILNLPGESTLRRDFLRLQLANKERSE 366
Query: 736 ALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAEC 795
AL+ QLE + ++ + K +LAE+ ++ E Q RL+E Q E
Sbjct: 367 ALRRQQLE-----------QQQRENEEHKRQLLAERQKRI--EEQKEQRRRLEEQQRREK 413
Query: 796 QALRLQLQQEMELLNAYQSKIKMQTE---AQHERELQKLEQRVSLRRAHLEQKIEEE--- 849
+ L+ QQE E Y+ +++ + E A+HE+E ++ + + L++++++E
Sbjct: 414 E---LRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDY 470
Query: 850 LAALQKERSER 860
L +LQ +R E+
Sbjct: 471 LVSLQHQRQEQ 481
Score = 40.4 bits (93), Expect = 0.007
Identities = 33/190 (17%), Positives = 87/190 (45%), Gaps = 5/190 (2%)
Query: 416 PRPTQSVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQL 475
P Q ++ + + ER I+ + R + +++E + SG + ++
Sbjct: 278 PATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGE 337
Query: 476 IALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQ 535
+ L E R L+ ++ + ++ ++L ++Q E + ++ A +K+ ++
Sbjct: 338 PSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEE 397
Query: 536 QILAQQKKDLTTFLESQKKQYKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAE 595
Q +Q++ L E Q+++ ++ K++ +E+ ++E++ R ++H++ + Q E
Sbjct: 398 Q--KEQRRRLE---EQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLE 452
Query: 596 EEAHLLTQQR 605
E+ QR
Sbjct: 453 EQRQAERLQR 462
Score = 39.3 bits (90), Expect = 0.017
Identities = 38/188 (20%), Positives = 84/188 (44%), Gaps = 8/188 (4%)
Query: 689 YNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKV-----QTKQYKALKNHQLE 743
+++R E KH +R QP N + + +Q+K T K +T+ + + E
Sbjct: 274 HSQRPATEQLMKHPF-IRDQP-NERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEE 331
Query: 744 VTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQLQ 803
E +IL + R+ + + + +E + Q L + +E E +L +
Sbjct: 332 ENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLE-QQQRENEEHKRQLLAE 390
Query: 804 QEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKN 863
++ + + + +++ + + E+EL+K ++R R + + EEE + E+ + K
Sbjct: 391 RQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQ 450
Query: 864 LLERQERE 871
L E+++ E
Sbjct: 451 LEEQRQAE 458
Score = 33.9 bits (76), Expect = 0.70
Identities = 30/112 (26%), Positives = 54/112 (48%), Gaps = 8/112 (7%)
Query: 769 AEQYEQSINEMMASQALRLDEAQEAECQALRLQL--QQEMELLNAYQSKIKMQTEAQHER 826
+E+ E+ + S L L LRLQL ++ E L Q + + + +H+R
Sbjct: 326 SEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKR 385
Query: 827 EL-----QKLEQRVSLRRAHLEQKIEEELAALQKERSERIKNLLERQEREIE 873
+L +++E++ RR EQ+ E+ Q+ER +R ++ E+ RE E
Sbjct: 386 QLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQR-RHYEEQMRREEE 436
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 227 bits (578), Expect = 4e-59
Identities = 135/282 (47%), Positives = 172/282 (60%), Gaps = 14/282 (4%)
Query: 19 DPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQ 78
DPEELF L IG GSFG VY + HT EVVAIK + ++ ++ +DI +E+ L Q
Sbjct: 15 DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDL--EEAEDEIEDIQQEITVLSQ 72
Query: 79 LKHPNTIEYKGCYLKEHTAWLVMEYCLG-SASDLLEVHKKPLQEVEIAAITHGALHGLAY 137
P Y G YLK W++MEY G SA DLL+ PL+E IA I L GL Y
Sbjct: 73 CDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLK--PGPLEETYIATILREILKGLDY 130
Query: 138 LHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPA----NSFVGTPYWMAPEVILAM 193
LHS IHRDIKA N+LL+E G VKLADFG A + N+FVGTP+WMAPEVI
Sbjct: 131 LHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI--- 187
Query: 194 DEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQSNEWTDSFRRF 253
+ YD K DIWSLGIT IELA+ +PP +++ M L+ I +N PTL+ + + F+ F
Sbjct: 188 KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLE-GQHSKPFKEF 246
Query: 254 VDYCLQKIPQERPTSAELLRHDFVRR-DRPLRVLIDLIQRTK 294
V+ CL K P+ RPT+ ELL+H F+ R + L +LI R K
Sbjct: 247 VEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYK 288
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 225 bits (574), Expect = 1e-58
Identities = 225/938 (23%), Positives = 410/938 (43%), Gaps = 149/938 (15%)
Query: 19 DPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQ 78
+PE+ + + E+G G+FG VY A N TS + A K + ++ E+ +D + E+ L
Sbjct: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVID---TKSEEELEDYMVEIDILAS 85
Query: 79 LKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVH-KKPLQEVEIAAITHGALHGLAY 137
HPN ++ + E+ W+++E+C G A D + + ++PL E +I + L L Y
Sbjct: 86 CDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNY 145
Query: 138 LHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPA----NSFVGTPYWMAPEVIL-- 191
LH + +IHRD+KAGNIL T G +KLADFG ++ + +SF+GTPYWMAPEV++
Sbjct: 146 LHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCE 205
Query: 192 AMDEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTL-QSNEWTDSF 250
+ YD K D+WSLGIT IE+AE +PP +N M L IA+++ PTL Q + W+ +F
Sbjct: 206 TSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNF 265
Query: 251 RRFVDYCLQKIPQERPTSAELLRHDFVRRD--RPLRVLIDLIQRTKDAVRELDNLQYRKM 308
+ F+ CL+K R T+++LL+H FV D +P+R +LI K V E
Sbjct: 266 KDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIR---ELIAEAKAEVTE--------- 313
Query: 309 KKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPSMSVSTGSQSSSVNSMQ 368
E +G + +++EE++E+ + + S +S S S
Sbjct: 314 ------EVEDG---KEEDEEEETENSLPIPASKRA--------SSDLSIASSEEDKLSQN 356
Query: 369 EVMDESSSELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDPRPEPRPTQSVQSQALH 428
+ ES SE + E +N S ++++K ++A D Q LH
Sbjct: 357 ACILESVSEKTERSNSEDKLN--SKILNEKPTTDEPEKAVE-DINEHITDAQLEAMTELH 413
Query: 429 YRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQLIALENKLKAEMDE 488
+R A IK R E+ + E +E + + +I LE ++ +
Sbjct: 414 ----DRTAVIKENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKS 469
Query: 489 HRLKLQKEVETHANN--SSIELEKLAKKQVAII-----EKEAKVAAADE-----KKFQQQ 536
K Q++ + N S E++ + V ++ EKEA + A D K+ Q+
Sbjct: 470 EEEKDQEKQQMFENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQE 529
Query: 537 ILAQQKKDLTTFLESQKKQYKICK-----EKIKEEMNEDHSTPKKEKQERISKHKENLQH 591
L + K + + C+ +K+ E+ ED T + +E + ++ +
Sbjct: 530 KLGEDDKTQKDVISNTSDVIGTCEAADVAQKVDEDSAED--TQSNDGKEVVEVGQKLINK 587
Query: 592 TQAEEEAHLLTQQRLYYDKNCRFFKRKIMIKRHEVEQQNIREELNKKRTQKEMEHAMLIR 651
EA +++ IK VE I E NK++ E+ M I
Sbjct: 588 PMVGPEAG---------------GTKEVPIK-EIVEMNEIEEGKNKEQAINSSENIMDIN 631
Query: 652 HD------------ESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKRR-ERELH 698
+ ST E+E R + + +Q +++ Q++ K+ +
Sbjct: 632 EEPGTTEGEEITESSSTEEMEVRSVVADTDQKALGSEVQDASKVTTQIDKEKKEIPVSIK 691
Query: 699 RKHVMELRQQPK----------NLKAMEMQIKKQFQDTCKVQTKQYKALKNHQ------- 741
++ + + QP N+ + + K++ K +T +N +
Sbjct: 692 KEPEVTVVSQPTEPQPVLIPSININSDSGENKEEIGSLSKTETILPPESENPKENDNDSG 751
Query: 742 -------------------LEVTPKNEHKTILKTLKDEQTRKLA--ILAEQYEQSINEMM 780
L T + ++ +T + ++T K + + E S+
Sbjct: 752 TGSTADTSSIDLNLSISSFLSKTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVT--- 808
Query: 781 ASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRA 840
S+ + +++ E + LR Q +E+ L + + +R Q+L ++ +R
Sbjct: 809 TSKIVTDSDSKTEELRFLRRQELRELRFL-----------QKEEQRAQQQLNSKLQQQRE 857
Query: 841 HLEQKIEEELAALQKERSERIKNLLERQEREIETFDME 878
+ ++ E+E+ + +++ + I+NL ++Q++ IE + E
Sbjct: 858 QIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQE 895
Score = 94.7 bits (234), Expect = 3e-19
Identities = 112/569 (19%), Positives = 240/569 (42%), Gaps = 60/569 (10%)
Query: 309 KKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSI---PSMSVSTGSQSSSVN 365
+K L E ++ +Q D+E E S+ +E + + P + S S S
Sbjct: 662 QKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSGE 721
Query: 366 SMQEVMDESSSELVMMHDDE------------STINSSSSVVHKKDHVFIRDEAGHGDPR 413
+ +E+ S +E ++ + E ST ++SS ++ F+ G
Sbjct: 722 NKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLSKTKDSGSIS 781
Query: 414 PEPRPTQSVQSQALHYRNRERF------ATIKSASLVTRQIHEHEQENELREQ-MSGYKR 466
Q + Q + +F ++ ++ +VT + E+ LR Q + +
Sbjct: 782 -----LQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRF 836
Query: 467 MRRQHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVA 526
++++ Q+ L +KL+ + ++ + ++E+ + E+E L K+Q IE+ +
Sbjct: 837 LQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEH 896
Query: 527 AADEKKFQQQILAQQKKDLTTFLESQKKQYKICKEKIKEEMNEDHSTPKKEKQERISKHK 586
+ ++I +Q+K+L+ F + K + KE +NE PK+ ++E + + K
Sbjct: 897 TNRLRDEAKRIKGEQEKELSKF-------QNMLKNRKKEVINEVEKAPKELRKELMKRRK 949
Query: 587 ENLQHTQAEEEAHLLTQQRLYYDKNCRFFKRKIMIKRHEVEQQNIREEL--NKKRTQKEM 644
E L +Q +E + +Q+ D + K +I++ + E NI E NK++ +
Sbjct: 950 EELAQSQHAQEQEFVQKQQQELDGSL-----KKIIQQQKAELANIERECLNNKQQLMRAR 1004
Query: 645 EHAMLI---RHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKH 701
E A+ RH + +L +QL ++ + +H+ E E YN+R EL +
Sbjct: 1005 EAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQ 1064
Query: 702 VMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQLEVTPKNEHKTILKTLKDEQ 761
E + PK ++ F+ + ++ + TP + I + E+
Sbjct: 1065 TQERARLPKIQRSEAKTRMAMFKKSLRINS-----------TATPDQDRDKIKQFAAQEE 1113
Query: 762 TRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTE 821
R+ Q+++ N+M Q EA + L ++ LL ++++ + +
Sbjct: 1114 KRQKNERMAQHQKHENQMRDLQL-----QCEANVRELHQLQNEKCHLLVEHETQKLKELD 1168
Query: 822 AQHERELQKLEQRVSLRRAHLEQKIEEEL 850
+H +EL++ +++ R+ LE++ +L
Sbjct: 1169 EEHSQELKEWREKLRPRKKTLEEEFARKL 1197
Score = 70.1 bits (170), Expect = 9e-12
Identities = 106/520 (20%), Positives = 201/520 (38%), Gaps = 85/520 (16%)
Query: 282 PLRVLIDLIQRTKDAVRELDNL-QYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNRE 340
P VLI I D+ + + K + IL E+ N E D++ GT +
Sbjct: 705 PQPVLIPSININSDSGENKEEIGSLSKTETILPPESEN-------PKENDNDSGTGSTAD 757
Query: 341 MDSLGSNHSIPS-MSVSTGSQSSSVNSMQEVMDESSSELVMMHDDESTINSSSSVVHKKD 399
S+ N SI S +S + S S S+ + + D ++S +V D
Sbjct: 758 TSSIDLNLSISSFLSKTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSD 817
Query: 400 HV-----FIRDEAGHGD---PRPEPRPTQSVQSQALHYRNRERFATIKSASLVTRQIHEH 451
F+R + + E R Q + S+ L + + F + + ++ ++
Sbjct: 818 SKTEELRFLRRQELRELRFLQKEEQRAQQQLNSK-LQQQREQIFRRFEQEMMSKKRQYDQ 876
Query: 452 EQENELREQMSGYKRMRRQHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELEKL 511
E EN ++Q +R+ ++H +L ++K E ++ K Q ++ E+EK
Sbjct: 877 EIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKA 936
Query: 512 AKKQVAIIEKEAKVAAADEKKFQQQ----------------ILAQQKKDLTTFLE---SQ 552
K+ + K K A + Q+Q I+ QQK +L +
Sbjct: 937 PKELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNN 996
Query: 553 KKQYKICKEKIKEEMNEDHSTPKKE-------------KQERISKHK------------- 586
K+Q +E E+ E H K + + + + +H+
Sbjct: 997 KQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRL 1056
Query: 587 -ENLQHTQAEEEAHLLTQQRLYYDKNCRFFKRKIMIK--------RHEVEQQNIREELNK 637
E L++ Q +E A L QR FK+ + I R +++Q +EE +
Sbjct: 1057 IEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQ 1116
Query: 638 K--RTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRER 695
K R + +H +R + E R+LH LQ + L+ ++H+T+ + +
Sbjct: 1117 KNERMAQHQKHENQMRDLQLQCEANVRELHQLQNEKCHLL-VEHETQ----------KLK 1165
Query: 696 ELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYK 735
EL +H EL++ + L+ + ++++F + Q +K
Sbjct: 1166 ELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQEVFFK 1205
Score = 67.4 bits (163), Expect = 6e-11
Identities = 103/574 (17%), Positives = 233/574 (40%), Gaps = 55/574 (9%)
Query: 330 DSEHGTSLNREMDSLGSNHSIPSMSVSTGSQ---SSSVNSMQEVMDESSSELVMMHDDES 386
DSE G + + LG + +S S + + + +DE S+E +D +
Sbjct: 517 DSEVGLTKEDTQEKLGEDDKTQKDVISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKE 576
Query: 387 TINSSSSVVHKKDHVFIRDEAGHGDPRPEPRPTQSVQSQALHYRNRERFATIKSASLVTR 446
+ +++K + EAG P + ++ +N+E+ I S+ +
Sbjct: 577 VVEVGQKLINKP---MVGPEAGGTKEVPIKEIVE--MNEIEEGKNKEQ--AINSSENIM- 628
Query: 447 QIHEHEQENELREQMSGYKRMRRQHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSI 506
I+E E E+++ + ++A D + L EV+ A+ +
Sbjct: 629 DINEEPGTTE-GEEITESSSTEEMEVRSVVA---------DTDQKALGSEVQD-ASKVTT 677
Query: 507 ELEKLAKKQVAIIEKEAKVAAADEKKFQQQILAQQKKDLTTFLESQKKQYKICKEKI--- 563
+++K K+ I+KE +V + Q +L + E++++ + K +
Sbjct: 678 QIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSGENKEEIGSLSKTETILP 737
Query: 564 -----KEEMNEDHSTPKKEKQERISKHKENLQHTQAEEEAHLLTQQRLYYDKNCRFFKRK 618
+E + D T I + +++ ++ Q K RK
Sbjct: 738 PESENPKENDNDSGTGSTADTSSIDLNLSISSFLSKTKDSGSISLQETRRQKKTLKKTRK 797
Query: 619 IMIKRHEV---------EQQNIREELNKKRTQKEMEHAMLIRHDESTRE-----LEYRQL 664
++ EV + + EEL R Q+ E L + ++ ++ L+ ++
Sbjct: 798 FIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKEEQRAQQQLNSKLQQQRE 857
Query: 665 HTLQKLRMDLI--RLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQ 722
++ +++ + Q+ E+EN + K+ L ++H LR + K +K + + +
Sbjct: 858 QIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSK 917
Query: 723 FQDTCKVQTKQYKALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMAS 782
FQ+ K + K+ +++E PK K ++K K+E + +++ Q + +
Sbjct: 918 FQNMLKNRKKEVI----NEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDG 973
Query: 783 QALRLDEAQEAECQALRLQ-LQQEMELLNAYQSKI----KMQTEAQHERELQKLEQRVSL 837
++ + Q+AE + + L + +L+ A ++ I + + +H+ Q+L+ + +
Sbjct: 974 SLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFM 1033
Query: 838 RRAHLEQKIEEELAALQKERSERIKNLLERQERE 871
+R L ++ E+E +Q+ I+ L RQ +E
Sbjct: 1034 QRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQE 1067
Score = 43.5 bits (101), Expect = 9e-04
Identities = 80/416 (19%), Positives = 154/416 (37%), Gaps = 34/416 (8%)
Query: 254 VDYCLQKIPQERPTSAELLRHDFVRRD--RPLRVLIDLIQRTKDAVRELDNLQYRKMKKI 311
V KI + + E LR F+RR R LR L QR + + Q ++ +
Sbjct: 805 VSVTTSKIVTDSDSKTEELR--FLRRQELRELRFLQKEEQRAQQQLNSKLQQQREQIFRR 862
Query: 312 LFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPSMSVSTGSQSSSVNSMQEVM 371
QE + QE E + ++ +N G Q ++ Q ++
Sbjct: 863 FEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNML 922
Query: 372 DESSSELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDPRPEPRPTQSVQSQA----- 426
E++ + + + + K+ ++E E Q Q +
Sbjct: 923 KNRKKEVI------NEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLK 976
Query: 427 -LHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQLIALENKLKAE 485
+ + + A I+ L +Q +E + E + Q + QL+ + K +
Sbjct: 977 KIIQQQKAELANIERECLNNKQQLMRAREAAIWE----LEERHLQEKHQLLKQQLKDQYF 1032
Query: 486 MDEHRL--KLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQQILAQQKK 543
M H+L + +KE E + +E+L +Q + K+ ++ K +A KK
Sbjct: 1033 MQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTR----MAMFKK 1088
Query: 544 DLTTFLESQKKQYKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEEEA----- 598
L + Q + +KIK+ ++ K E+ + KH+ ++ Q + EA
Sbjct: 1089 SLRINSTATPDQDR---DKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQLQCEANVREL 1145
Query: 599 HLLTQQRLYYDKNCRFFKRKIMIKRHEVEQQNIREELNKKRTQKEMEHAMLIRHDE 654
H L ++ + K K + + H E + RE+L ++ E E A ++ E
Sbjct: 1146 HQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQE 1201
Score = 42.0 bits (97), Expect = 0.003
Identities = 43/190 (22%), Positives = 79/190 (41%), Gaps = 29/190 (15%)
Query: 702 VMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQLEVTPKNEHKTILKTLKDEQ 761
+ E R+Q K LK + +K D +V K VT + L+ L+ ++
Sbjct: 782 LQETRRQKKTLK----KTRKFIVDGVEVSVTTSKI-------VTDSDSKTEELRFLRRQE 830
Query: 762 TRKLAILAEQYE---QSINEMMASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKM 818
R+L L ++ + Q +N + Q ++ E E + + Q QE+E L Q +
Sbjct: 831 LRELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIE 890
Query: 819 QTEAQH---------------ERELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKN 863
+ E +H E+EL K + + R+ + ++E+ L+KE +R K
Sbjct: 891 RLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKE 950
Query: 864 LLERQEREIE 873
L + + E
Sbjct: 951 ELAQSQHAQE 960
Score = 41.6 bits (96), Expect = 0.003
Identities = 50/227 (22%), Positives = 101/227 (44%), Gaps = 21/227 (9%)
Query: 662 RQLHTLQKLR---MDLIRLQHQT-ELENQLEYNKRRERELHRKHVMELR---------QQ 708
RQ TL+K R +D + + T ++ + R L R+ + ELR QQ
Sbjct: 787 RQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKEEQRAQQ 846
Query: 709 PKNLKAMEM--QIKKQFQDTCKVQTKQYKALKNHQLEVTPKNEHKTILKTLKDEQTRKLA 766
N K + QI ++F+ + +QY + ++E K + +TI + L+ E T +L
Sbjct: 847 QLNSKLQQQREQIFRRFEQEMMSKKRQY----DQEIENLEKQQKQTI-ERLEQEHTNRLR 901
Query: 767 ILAEQYE-QSINEMMASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHE 825
A++ + + E+ Q + + +E + + + EL+ + ++ AQ +
Sbjct: 902 DEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQ 961
Query: 826 RELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKNLLERQEREI 872
+QK +Q + + Q+ + ELA +++E + L+ +E I
Sbjct: 962 EFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAI 1008
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 224 bits (570), Expect = 4e-58
Identities = 130/281 (46%), Positives = 169/281 (60%), Gaps = 12/281 (4%)
Query: 19 DPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQ 78
DPEELF L IG GSFG V+ + T +VVAIK + ++ ++ +DI +E+ L Q
Sbjct: 19 DPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDL--EEAEDEIEDIQQEITVLSQ 76
Query: 79 LKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALHGLAYL 138
+Y G YLK W++MEY LG S L + P E +IA + L GL YL
Sbjct: 77 CDSSYVTKYYGSYLKGSKLWIIMEY-LGGGSALDLLRAGPFDEFQIATMLKEILKGLDYL 135
Query: 139 HSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPA----NSFVGTPYWMAPEVILAMD 194
HS IHRDIKA N+LL+E G VKLADFG A + N+FVGTP+WMAPEVI
Sbjct: 136 HSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI---Q 192
Query: 195 EGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQSNEWTDSFRRFV 254
+ YD K DIWSLGIT IELA+ +PP +M+ M L+ I +N+ PTL ++T SF+ F+
Sbjct: 193 QSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTL-VGDFTKSFKEFI 251
Query: 255 DYCLQKIPQERPTSAELLRHDF-VRRDRPLRVLIDLIQRTK 294
D CL K P RPT+ ELL+H F V+ + L +LI R K
Sbjct: 252 DACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFK 292
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 216 bits (550), Expect = 8e-56
Identities = 184/612 (30%), Positives = 291/612 (47%), Gaps = 120/612 (19%)
Query: 13 DLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKE 72
DL DP +F + +G+G++G VY + T ++ AIK M T ++ ++I E
Sbjct: 14 DLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV----TEDEEEEIKLE 69
Query: 73 VKFLRQLKHPNTIE-YKGCYLK------EHTAWLVMEYC-LGSASDLLEVHK-KPLQEVE 123
+ L++ H I Y G ++K + WLVME+C GS +DL++ K L+E
Sbjct: 70 INMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDW 129
Query: 124 IAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPA----NSFV 179
IA I+ L GLA+LH H +IHRDIK N+LLTE +VKL DFG ++ N+F+
Sbjct: 130 IAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFI 189
Query: 180 GTPYWMAPEVILAMDEGQ---YDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQN 236
GTPYWMAPEVI A DE YD + D+WS GIT IE+AE PPL +M+ M AL+ I +N
Sbjct: 190 GTPYWMAPEVI-ACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN 248
Query: 237 DSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVR---RDRPLRV-LIDLIQR 292
P L+S +W+ F F++ CL K +RP++ +LL+H F+R +R +R+ L D I R
Sbjct: 249 PPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDR 308
Query: 293 TKDAVRELDNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPS 352
T+ E D +Y + S+E+EE+ +P
Sbjct: 309 TRKKRGEKDETEYE--------------YSGSEEEEEE-------------------VPE 335
Query: 353 MSVSTGSQSSSVNSMQEVMDESSSELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDP 412
G SS VN EST+ F+R + + +
Sbjct: 336 QE---GEPSSIVNV----------------PGESTLRRD----------FLRLQQENKER 366
Query: 413 RPEPRPTQSVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQ 472
R Q +Q Q L R +E + A R + EQ L EQ + RRQ +
Sbjct: 367 SEALRRQQLLQEQQL--REQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQE 424
Query: 473 KQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKK 532
+ E + + + ++ RL+ ELE+ K E+E + A +EK+
Sbjct: 425 R-----EQRRREQEEKRRLE--------------ELERRRK------EEEERRRAEEEKR 459
Query: 533 FQQQILAQQKKDLTTFLESQKKQYKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHT 592
+ ++++ + LE +++ ++ ++++ +E +E +E + E LQ
Sbjct: 460 ----RVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEH--RQAERLQRQ 513
Query: 593 QAEEEAHLLTQQ 604
+E+A+LL+ Q
Sbjct: 514 LQQEQAYLLSLQ 525
Score = 54.3 bits (129), Expect = 5e-07
Identities = 59/236 (25%), Positives = 108/236 (45%), Gaps = 22/236 (9%)
Query: 628 QQNIREELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQL 687
QQ +E R Q+ ++ L +E R+L L QK R++ Q E +L
Sbjct: 360 QQENKERSEALRRQQLLQEQQLREQEEYKRQL----LAERQK------RIEQQKEQRRRL 409
Query: 688 EYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQLEVTPK 747
E +RRERE RQQ + + E + K++ ++ + + ++ + + + + +
Sbjct: 410 EEQQRREREAR-------RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVE 462
Query: 748 NEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQLQQEME 807
E + I + L++EQ R L +L +Q Q ++ + ++E ++AE L+ QLQQE
Sbjct: 463 REQEYIRRQLEEEQ-RHLEVLQQQLLQEQAMLLECRWREMEEHRQAE--RLQRQLQQEQA 519
Query: 808 LLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHL-EQKIEEELAALQKERSERIK 862
L + Q + + QH ++ +Q S H E K E A +E +R +
Sbjct: 520 YLLSLQHDHR-RPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVEDRFR 574
Score = 47.8 bits (112), Expect = 5e-05
Identities = 55/223 (24%), Positives = 93/223 (41%), Gaps = 38/223 (17%)
Query: 689 YNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTK------QYKALKNHQL 742
Y +R E KH +R QP N + + +Q+K T K + + +Y + +
Sbjct: 274 YMQRPSTEQLLKHPF-IRDQP-NERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEE 331
Query: 743 EVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQL 802
EV + + + + E T + L Q E S+ALR + + Q LR Q
Sbjct: 332 EVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKER----SEALRRQQLLQE--QQLREQE 385
Query: 803 QQEMELLNAYQSKIKMQTEAQH--------ERELQKLEQRVSLRRAHLEQKIEEELAALQ 854
+ + +LL Q +I+ Q E + ERE ++ ++R RR E++ EEL +
Sbjct: 386 EYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRR 445
Query: 855 KERSER----------------IKNLLERQEREIETFDMESLR 881
KE ER I+ LE ++R +E + L+
Sbjct: 446 KEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQ 488
Score = 45.1 bits (105), Expect = 3e-04
Identities = 61/256 (23%), Positives = 118/256 (46%), Gaps = 17/256 (6%)
Query: 459 EQMSGYKRMRRQHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAI 518
EQ+ + +R Q ++ + ++ LK +D R K ++ ET S E E+ ++V
Sbjct: 281 EQLLKHPFIRDQPNERQVRIQ--LKDHIDRTRKKRGEKDETEYEYSGSEEEE---EEVPE 335
Query: 519 IEKEAK--VAAADEKKFQQQILAQQKKDLTTFLESQKKQYKICKEKIKEEMNEDHSTPKK 576
E E V E ++ L Q+++ E+ ++Q + +++++E+ E
Sbjct: 336 QEGEPSSIVNVPGESTLRRDFLRLQQENKERS-EALRRQQLLQEQQLREQ-EEYKRQLLA 393
Query: 577 EKQERISKHKENLQHTQAEE--EAHLLTQQRLYYDKNCRFFKRKI--MIKRHEVEQQNIR 632
E+Q+RI + KE + + ++ E QQ + + KR++ + +R + E++ R
Sbjct: 394 ERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRR 453
Query: 633 EELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKR 692
E K+R ++E E+ + +E R LE Q LQ+ M L + E Q E R
Sbjct: 454 AEEEKRRVEREQEYIRR-QLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAE---R 509
Query: 693 RERELHRKHVMELRQQ 708
+R+L ++ L Q
Sbjct: 510 LQRQLQQEQAYLLSLQ 525
Score = 41.6 bits (96), Expect = 0.003
Identities = 42/207 (20%), Positives = 98/207 (47%), Gaps = 18/207 (8%)
Query: 550 ESQKKQYKIC-KEKIKEEMNEDHSTPKKE---------KQERISKHKENLQHTQAEEEAH 599
E + +Y+ E+ +EE+ E P +++ + +EN + ++A
Sbjct: 315 EKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQ 374
Query: 600 LLTQQRLYYDKNCRFFKRKIMIKRHE-VEQQNIREELNKKRTQKEMEHAMLIRHDESTRE 658
LL +Q+L + +KR+++ +R + +EQQ + +++ ++E E ++ RE
Sbjct: 375 LLQEQQLREQEE---YKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRRE 431
Query: 659 LEY-RQLHTLQKLRMDLIRLQHQTELENQLEYNK---RRERELHRKHVMELRQQPKNLKA 714
E R+L L++ R + + E + ++E + RR+ E ++H+ L+QQ +A
Sbjct: 432 QEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQA 491
Query: 715 MEMQIKKQFQDTCKVQTKQYKALKNHQ 741
M ++ + + + + + + L+ Q
Sbjct: 492 MLLECRWREMEEHRQAERLQRQLQQEQ 518
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 214 bits (546), Expect = 2e-55
Identities = 182/587 (31%), Positives = 281/587 (47%), Gaps = 89/587 (15%)
Query: 13 DLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKE 72
DL DP +F + +G+G++G VY + T ++ AIK M T ++ ++I +E
Sbjct: 14 DLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV----TEDEEEEIKQE 69
Query: 73 VKFLRQLKHPNTIE-YKGCYLK------EHTAWLVMEYC-LGSASDLLEVHK-KPLQEVE 123
+ L++ H I Y G ++K + WLVME+C GS +DL++ K L+E
Sbjct: 70 INMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDC 129
Query: 124 IAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPA----NSFV 179
IA I L GLA+LH+H +IHRDIK N+LLTE +VKL DFG ++ N+F+
Sbjct: 130 IAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFI 189
Query: 180 GTPYWMAPEVILAMDEGQ---YDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQN 236
GTPYWMAPEVI A DE YD + DIWSLGIT IE+AE PPL +M+ M AL+ I +N
Sbjct: 190 GTPYWMAPEVI-ACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN 248
Query: 237 DSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVR---RDRPLRV-LIDLIQR 292
P L+S +W+ F F+D CL K RP + +LL+ F+R +R +R+ L D I R
Sbjct: 249 PPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDR 308
Query: 293 TKDAVRELDNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPS 352
++ E + +Y S +EED HG G SI +
Sbjct: 309 SRKKRGEKEETEY----------------EYSGSEEEDDSHGEE--------GEPSSIMN 344
Query: 353 MSVSTGSQSSSVNSMQEVMDESSSELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDP 412
+ + + + QE ++S+SE + H K H+ + + +
Sbjct: 345 VPGESTLRREFLRLQQE--NKSNSEALKQQQQLQQQQQRDPEAHIK-HLLHQRQRRIEEQ 401
Query: 413 RPEPRPTQSVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKR--MRRQ 470
+ E R + Q R RE+ R++ E EQ+ L E M +R RRQ
Sbjct: 402 KEERRRVEEQQR-----REREQ-----------RKLQEKEQQRRL-EDMQALRREEERRQ 444
Query: 471 HQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADE 530
+++ +L+ + RL+ Q + E HA S++ ++ ++ +
Sbjct: 445 AEREQEYKRKQLEEQRQSERLQRQLQQE-HAYLKSLQQQQQQQQL--------------Q 489
Query: 531 KKFQQQILAQQKKDLTTFLESQKKQYKICKEKIKEE---MNEDHSTP 574
K+ QQQ+L +K L + K + EE MN+ ++P
Sbjct: 490 KQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSP 536
Score = 50.8 bits (120), Expect = 6e-06
Identities = 41/172 (23%), Positives = 89/172 (51%), Gaps = 35/172 (20%)
Query: 670 LRMDLIRLQHQTEL-------ENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQ 722
LR + +RLQ + + + QL+ ++R+ E H KH++ RQ+ +I++Q
Sbjct: 351 LRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQR---------RIEEQ 401
Query: 723 FQDTCKVQTKQYKALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMAS 782
++ +V+ +Q + + +L+ + ++ L+ E+ R+ A ++Y++
Sbjct: 402 KEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRK------- 454
Query: 783 QALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQR 834
+L+E +++E L+ QLQQE +AY ++ Q Q +++LQK +Q+
Sbjct: 455 ---QLEEQRQSE--RLQRQLQQE----HAYLKSLQQQ---QQQQQLQKQQQQ 494
Score = 44.7 bits (104), Expect = 4e-04
Identities = 53/230 (23%), Positives = 104/230 (45%), Gaps = 35/230 (15%)
Query: 459 EQMSGYKRMRRQHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELE--------- 509
EQ+ + +R Q ++ + ++ LK +D R K ++ ET S E E
Sbjct: 281 EQLLKFPFIRDQPTERQVRIQ--LKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGE 338
Query: 510 ----------KLAKKQVAIIEKEAKVAAADEKKFQQQILAQQKKDLTTFLESQKKQYKIC 559
+++ +++E K + ++ K QQQ+ QQ++D ++ Q +
Sbjct: 339 PSSIMNVPGESTLRREFLRLQQENK-SNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRR 397
Query: 560 KEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEEEAHLLTQQRLYYDKNCRFFKRKI 619
E+ KEE + E+Q+R + + LQ + E++ L Q L ++ R +R+
Sbjct: 398 IEEQKEERR------RVEEQQRREREQRKLQ--EKEQQRRLEDMQALRREEERRQAEREQ 449
Query: 620 MIKRHEVEQQNIREELNKKRTQKEMEHAML--IRHDESTRELEYRQLHTL 667
KR ++E+Q E L + Q + EHA L ++ + ++L+ +Q L
Sbjct: 450 EYKRKQLEEQRQSERLQR---QLQQEHAYLKSLQQQQQQQQLQKQQQQQL 496
Score = 39.3 bits (90), Expect = 0.017
Identities = 37/180 (20%), Positives = 73/180 (40%), Gaps = 16/180 (8%)
Query: 705 LRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQLEVTPKNEHK---------TILK 755
+R QP E Q++ Q +D K+ + + E + E + +
Sbjct: 289 IRDQPT-----ERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIM 343
Query: 756 TLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQA--LRLQLQQEMELLNAYQ 813
+ E T + L Q E N Q +L + Q+ + +A L Q++ + +
Sbjct: 344 NVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKE 403
Query: 814 SKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKNLLERQEREIE 873
+ +++ + + ERE +KL+++ RR Q + E Q ER + K ++R+ E
Sbjct: 404 ERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSE 463
Score = 37.7 bits (86), Expect = 0.048
Identities = 30/154 (19%), Positives = 69/154 (44%), Gaps = 9/154 (5%)
Query: 632 REELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNK 691
RE L ++ K A+ + ++ + H L R++ Q E ++E +
Sbjct: 353 REFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQ 412
Query: 692 RRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQLEVTPKNEHK 751
RRERE + E +++ ++++A+ + +++ Q ++ + K QLE ++E
Sbjct: 413 RREREQRKLQEKEQQRRLEDMQALRREEERR-------QAEREQEYKRKQLEEQRQSER- 464
Query: 752 TILKTLKDEQTRKLAILAEQYEQSINEMMASQAL 785
+ + L+ E ++ +Q +Q + + Q L
Sbjct: 465 -LQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLL 497
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 214 bits (546), Expect = 2e-55
Identities = 182/587 (31%), Positives = 281/587 (47%), Gaps = 89/587 (15%)
Query: 13 DLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKE 72
DL DP +F + +G+G++G VY + T ++ AIK M T ++ ++I +E
Sbjct: 14 DLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV----TEDEEEEIKQE 69
Query: 73 VKFLRQLKHPNTIE-YKGCYLK------EHTAWLVMEYC-LGSASDLLEVHK-KPLQEVE 123
+ L++ H I Y G ++K + WLVME+C GS +DL++ K L+E
Sbjct: 70 INMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDC 129
Query: 124 IAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPA----NSFV 179
IA I L GLA+LH+H +IHRDIK N+LLTE +VKL DFG ++ N+F+
Sbjct: 130 IAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFI 189
Query: 180 GTPYWMAPEVILAMDEGQ---YDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQN 236
GTPYWMAPEVI A DE YD + DIWSLGIT IE+AE PPL +M+ M AL+ I +N
Sbjct: 190 GTPYWMAPEVI-ACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN 248
Query: 237 DSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVR---RDRPLRV-LIDLIQR 292
P L+S +W+ F F+D CL K RP + +LL+ F+R +R +R+ L D I R
Sbjct: 249 PPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDR 308
Query: 293 TKDAVRELDNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPS 352
++ E + +Y S +EED HG G SI +
Sbjct: 309 SRKKRGEKEETEY----------------EYSGSEEEDDSHGEE--------GEPSSIMN 344
Query: 353 MSVSTGSQSSSVNSMQEVMDESSSELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDP 412
+ + + + QE ++S+SE + H K H+ + + +
Sbjct: 345 VPGESTLRREFLRLQQE--NKSNSEALKQQQQLQQQQQRDPEAHIK-HLLHQRQRRIEEQ 401
Query: 413 RPEPRPTQSVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKR--MRRQ 470
+ E R + Q R RE+ R++ E EQ+ L E M +R RRQ
Sbjct: 402 KEERRRVEEQQR-----REREQ-----------RKLQEKEQQRRL-EDMQALRREEERRQ 444
Query: 471 HQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADE 530
+++ +L+ + RL+ Q + E HA S++ ++ ++ +
Sbjct: 445 AEREQEYKRKQLEEQRQSERLQRQLQQE-HAYLKSLQQQQQQQQL--------------Q 489
Query: 531 KKFQQQILAQQKKDLTTFLESQKKQYKICKEKIKEE---MNEDHSTP 574
K+ QQQ+L +K L + K + EE MN+ ++P
Sbjct: 490 KQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSP 536
Score = 51.2 bits (121), Expect = 4e-06
Identities = 74/352 (21%), Positives = 144/352 (40%), Gaps = 51/352 (14%)
Query: 459 EQMSGYKRMRRQHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELE--------- 509
EQ+ + +R Q ++ + ++ LK +D R K ++ ET S E E
Sbjct: 281 EQLLKFPFIRDQPTERQVRIQ--LKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGE 338
Query: 510 ----------KLAKKQVAIIEKEAKVAAADEKKFQQQILAQQKKDLTTFLESQKKQYKIC 559
+++ +++E K + ++ K QQQ+ QQ++D ++ Q +
Sbjct: 339 PSSIMNVPGESTLRREFLRLQQENK-SNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRR 397
Query: 560 KEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEEEAHLLTQQRLYYDKNCRFFKRKI 619
E+ KEE + E+Q+R + + LQ + E++ L Q L ++ R +R+
Sbjct: 398 IEEQKEERR------RVEEQQRREREQRKLQ--EKEQQRRLEDMQALRREEERRQAEREQ 449
Query: 620 MIKRHEVEQQNIREELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQH 679
KR ++E+Q E L + Q + EHA L + ++ + ++ Q L D L H
Sbjct: 450 EYKRKQLEEQRQSERLQR---QLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYH 506
Query: 680 -------------QTELENQLEYNKRRERELHRKHVMELRQQPKNLKAM-----EMQIKK 721
E+E + NK++ L + +P +A +
Sbjct: 507 YGRGMNPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTP 566
Query: 722 QFQDTCKVQTKQYKALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYE 773
Q + Q +K+L H++ + P ++L+D+ TR LA ++
Sbjct: 567 PMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHD 618
Score = 50.8 bits (120), Expect = 6e-06
Identities = 41/172 (23%), Positives = 89/172 (51%), Gaps = 35/172 (20%)
Query: 670 LRMDLIRLQHQTEL-------ENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQ 722
LR + +RLQ + + + QL+ ++R+ E H KH++ RQ+ +I++Q
Sbjct: 351 LRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQR---------RIEEQ 401
Query: 723 FQDTCKVQTKQYKALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMAS 782
++ +V+ +Q + + +L+ + ++ L+ E+ R+ A ++Y++
Sbjct: 402 KEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRK------- 454
Query: 783 QALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQR 834
+L+E +++E L+ QLQQE +AY ++ Q Q +++LQK +Q+
Sbjct: 455 ---QLEEQRQSE--RLQRQLQQE----HAYLKSLQQQ---QQQQQLQKQQQQ 494
Score = 39.3 bits (90), Expect = 0.017
Identities = 37/180 (20%), Positives = 73/180 (40%), Gaps = 16/180 (8%)
Query: 705 LRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQLEVTPKNEHK---------TILK 755
+R QP E Q++ Q +D K+ + + E + E + +
Sbjct: 289 IRDQPT-----ERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIM 343
Query: 756 TLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQA--LRLQLQQEMELLNAYQ 813
+ E T + L Q E N Q +L + Q+ + +A L Q++ + +
Sbjct: 344 NVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKE 403
Query: 814 SKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKNLLERQEREIE 873
+ +++ + + ERE +KL+++ RR Q + E Q ER + K ++R+ E
Sbjct: 404 ERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSE 463
Score = 37.7 bits (86), Expect = 0.048
Identities = 30/154 (19%), Positives = 69/154 (44%), Gaps = 9/154 (5%)
Query: 632 REELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNK 691
RE L ++ K A+ + ++ + H L R++ Q E ++E +
Sbjct: 353 REFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQ 412
Query: 692 RRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQLEVTPKNEHK 751
RRERE + E +++ ++++A+ + +++ Q ++ + K QLE ++E
Sbjct: 413 RREREQRKLQEKEQQRRLEDMQALRREEERR-------QAEREQEYKRKQLEEQRQSER- 464
Query: 752 TILKTLKDEQTRKLAILAEQYEQSINEMMASQAL 785
+ + L+ E ++ +Q +Q + + Q L
Sbjct: 465 -LQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLL 497
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 214 bits (546), Expect = 2e-55
Identities = 182/587 (31%), Positives = 281/587 (47%), Gaps = 89/587 (15%)
Query: 13 DLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKE 72
DL DP +F + +G+G++G VY + T ++ AIK M T ++ ++I +E
Sbjct: 14 DLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV----TEDEEEEIKQE 69
Query: 73 VKFLRQLKHPNTIE-YKGCYLK------EHTAWLVMEYC-LGSASDLLEVHK-KPLQEVE 123
+ L++ H I Y G ++K + WLVME+C GS +DL++ K L+E
Sbjct: 70 INMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDC 129
Query: 124 IAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPA----NSFV 179
IA I L GLA+LH+H +IHRDIK N+LLTE +VKL DFG ++ N+F+
Sbjct: 130 IAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFI 189
Query: 180 GTPYWMAPEVILAMDEGQ---YDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQN 236
GTPYWMAPEVI A DE YD + DIWSLGIT IE+AE PPL +M+ M AL+ I +N
Sbjct: 190 GTPYWMAPEVI-ACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN 248
Query: 237 DSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVR---RDRPLRV-LIDLIQR 292
P L+S +W+ F F+D CL K RP + +LL+ F+R +R +R+ L D I R
Sbjct: 249 PPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDR 308
Query: 293 TKDAVRELDNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPS 352
++ E + +Y S +EED HG G SI +
Sbjct: 309 SRKKRGEKEETEY----------------EYSGSEEEDDSHGEE--------GEPSSIMN 344
Query: 353 MSVSTGSQSSSVNSMQEVMDESSSELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDP 412
+ + + + QE ++S+SE + H K H+ + + +
Sbjct: 345 VPGESTLRREFLRLQQE--NKSNSEALKQQQQLQQQQQRDPEAHIK-HLLHQRQRRIEEQ 401
Query: 413 RPEPRPTQSVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKR--MRRQ 470
+ E R + Q R RE+ R++ E EQ+ L E M +R RRQ
Sbjct: 402 KEERRRVEEQQR-----REREQ-----------RKLQEKEQQRRL-EDMQALRREEERRQ 444
Query: 471 HQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADE 530
+++ +L+ + RL+ Q + E HA S++ ++ ++ +
Sbjct: 445 AEREQEYKRKQLEEQRQSERLQRQLQQE-HAYLKSLQQQQQQQQL--------------Q 489
Query: 531 KKFQQQILAQQKKDLTTFLESQKKQYKICKEKIKEE---MNEDHSTP 574
K+ QQQ+L +K L + K + EE MN+ ++P
Sbjct: 490 KQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSP 536
Score = 51.2 bits (121), Expect = 4e-06
Identities = 74/352 (21%), Positives = 144/352 (40%), Gaps = 51/352 (14%)
Query: 459 EQMSGYKRMRRQHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELE--------- 509
EQ+ + +R Q ++ + ++ LK +D R K ++ ET S E E
Sbjct: 281 EQLLKFPFIRDQPTERQVRIQ--LKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGE 338
Query: 510 ----------KLAKKQVAIIEKEAKVAAADEKKFQQQILAQQKKDLTTFLESQKKQYKIC 559
+++ +++E K + ++ K QQQ+ QQ++D ++ Q +
Sbjct: 339 PSSIMNVPGESTLRREFLRLQQENK-SNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRR 397
Query: 560 KEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEEEAHLLTQQRLYYDKNCRFFKRKI 619
E+ KEE + E+Q+R + + LQ + E++ L Q L ++ R +R+
Sbjct: 398 IEEQKEERR------RVEEQQRREREQRKLQ--EKEQQRRLEDMQALRREEERRQAEREQ 449
Query: 620 MIKRHEVEQQNIREELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQH 679
KR ++E+Q E L + Q + EHA L + ++ + ++ Q L D L H
Sbjct: 450 EYKRKQLEEQRQSERLQR---QLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYH 506
Query: 680 -------------QTELENQLEYNKRRERELHRKHVMELRQQPKNLKAM-----EMQIKK 721
E+E + NK++ L + +P +A +
Sbjct: 507 YGRGMNPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTP 566
Query: 722 QFQDTCKVQTKQYKALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYE 773
Q + Q +K+L H++ + P ++L+D+ TR LA ++
Sbjct: 567 PMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHD 618
Score = 50.8 bits (120), Expect = 6e-06
Identities = 41/172 (23%), Positives = 89/172 (51%), Gaps = 35/172 (20%)
Query: 670 LRMDLIRLQHQTEL-------ENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQ 722
LR + +RLQ + + + QL+ ++R+ E H KH++ RQ+ +I++Q
Sbjct: 351 LRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQR---------RIEEQ 401
Query: 723 FQDTCKVQTKQYKALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMAS 782
++ +V+ +Q + + +L+ + ++ L+ E+ R+ A ++Y++
Sbjct: 402 KEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRK------- 454
Query: 783 QALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQR 834
+L+E +++E L+ QLQQE +AY ++ Q Q +++LQK +Q+
Sbjct: 455 ---QLEEQRQSE--RLQRQLQQE----HAYLKSLQQQ---QQQQQLQKQQQQ 494
Score = 39.3 bits (90), Expect = 0.017
Identities = 37/180 (20%), Positives = 73/180 (40%), Gaps = 16/180 (8%)
Query: 705 LRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQLEVTPKNEHK---------TILK 755
+R QP E Q++ Q +D K+ + + E + E + +
Sbjct: 289 IRDQPT-----ERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIM 343
Query: 756 TLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQA--LRLQLQQEMELLNAYQ 813
+ E T + L Q E N Q +L + Q+ + +A L Q++ + +
Sbjct: 344 NVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKE 403
Query: 814 SKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKNLLERQEREIE 873
+ +++ + + ERE +KL+++ RR Q + E Q ER + K ++R+ E
Sbjct: 404 ERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSE 463
Score = 37.7 bits (86), Expect = 0.048
Identities = 30/154 (19%), Positives = 69/154 (44%), Gaps = 9/154 (5%)
Query: 632 REELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNK 691
RE L ++ K A+ + ++ + H L R++ Q E ++E +
Sbjct: 353 REFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQ 412
Query: 692 RRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQLEVTPKNEHK 751
RRERE + E +++ ++++A+ + +++ Q ++ + K QLE ++E
Sbjct: 413 RREREQRKLQEKEQQRRLEDMQALRREEERR-------QAEREQEYKRKQLEEQRQSER- 464
Query: 752 TILKTLKDEQTRKLAILAEQYEQSINEMMASQAL 785
+ + L+ E ++ +Q +Q + + Q L
Sbjct: 465 -LQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLL 497
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 214 bits (546), Expect = 2e-55
Identities = 182/587 (31%), Positives = 281/587 (47%), Gaps = 89/587 (15%)
Query: 13 DLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKE 72
DL DP +F + +G+G++G VY + T ++ AIK M T ++ ++I +E
Sbjct: 14 DLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV----TEDEEEEIKQE 69
Query: 73 VKFLRQLKHPNTIE-YKGCYLK------EHTAWLVMEYC-LGSASDLLEVHK-KPLQEVE 123
+ L++ H I Y G ++K + WLVME+C GS +DL++ K L+E
Sbjct: 70 INMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDC 129
Query: 124 IAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPA----NSFV 179
IA I L GLA+LH+H +IHRDIK N+LLTE +VKL DFG ++ N+F+
Sbjct: 130 IAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFI 189
Query: 180 GTPYWMAPEVILAMDEGQ---YDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQN 236
GTPYWMAPEVI A DE YD + DIWSLGIT IE+AE PPL +M+ M AL+ I +N
Sbjct: 190 GTPYWMAPEVI-ACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN 248
Query: 237 DSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVR---RDRPLRV-LIDLIQR 292
P L+S +W+ F F+D CL K RP + +LL+ F+R +R +R+ L D I R
Sbjct: 249 PPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDR 308
Query: 293 TKDAVRELDNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPS 352
++ E + +Y S +EED HG G SI +
Sbjct: 309 SRKKRGEKEETEY----------------EYSGSEEEDDSHGEE--------GEPSSIMN 344
Query: 353 MSVSTGSQSSSVNSMQEVMDESSSELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDP 412
+ + + + QE ++S+SE + H K H+ + + +
Sbjct: 345 VPGESTLRREFLRLQQE--NKSNSEALKQQQQLQQQQQRDPEAHIK-HLLHQRQRRIEEQ 401
Query: 413 RPEPRPTQSVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKR--MRRQ 470
+ E R + Q R RE+ R++ E EQ+ L E M +R RRQ
Sbjct: 402 KEERRRVEEQQR-----REREQ-----------RKLQEKEQQRRL-EDMQALRREEERRQ 444
Query: 471 HQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADE 530
+++ +L+ + RL+ Q + E HA S++ ++ ++ +
Sbjct: 445 AEREQEYKRKQLEEQRQSERLQRQLQQE-HAYLKSLQQQQQQQQL--------------Q 489
Query: 531 KKFQQQILAQQKKDLTTFLESQKKQYKICKEKIKEE---MNEDHSTP 574
K+ QQQ+L +K L + K + EE MN+ ++P
Sbjct: 490 KQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSP 536
Score = 51.2 bits (121), Expect = 4e-06
Identities = 74/352 (21%), Positives = 144/352 (40%), Gaps = 51/352 (14%)
Query: 459 EQMSGYKRMRRQHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELE--------- 509
EQ+ + +R Q ++ + ++ LK +D R K ++ ET S E E
Sbjct: 281 EQLLKFPFIRDQPTERQVRIQ--LKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGE 338
Query: 510 ----------KLAKKQVAIIEKEAKVAAADEKKFQQQILAQQKKDLTTFLESQKKQYKIC 559
+++ +++E K + ++ K QQQ+ QQ++D ++ Q +
Sbjct: 339 PSSIMNVPGESTLRREFLRLQQENK-SNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRR 397
Query: 560 KEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEEEAHLLTQQRLYYDKNCRFFKRKI 619
E+ KEE + E+Q+R + + LQ + E++ L Q L ++ R +R+
Sbjct: 398 IEEQKEERR------RVEEQQRREREQRKLQ--EKEQQRRLEDMQALRREEERRQAEREQ 449
Query: 620 MIKRHEVEQQNIREELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQH 679
KR ++E+Q E L + Q + EHA L + ++ + ++ Q L D L H
Sbjct: 450 EYKRKQLEEQRQSERLQR---QLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYH 506
Query: 680 -------------QTELENQLEYNKRRERELHRKHVMELRQQPKNLKAM-----EMQIKK 721
E+E + NK++ L + +P +A +
Sbjct: 507 YGRGMNPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTP 566
Query: 722 QFQDTCKVQTKQYKALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYE 773
Q + Q +K+L H++ + P ++L+D+ TR LA ++
Sbjct: 567 PMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHD 618
Score = 50.8 bits (120), Expect = 6e-06
Identities = 41/172 (23%), Positives = 89/172 (51%), Gaps = 35/172 (20%)
Query: 670 LRMDLIRLQHQTEL-------ENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQ 722
LR + +RLQ + + + QL+ ++R+ E H KH++ RQ+ +I++Q
Sbjct: 351 LRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQR---------RIEEQ 401
Query: 723 FQDTCKVQTKQYKALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMAS 782
++ +V+ +Q + + +L+ + ++ L+ E+ R+ A ++Y++
Sbjct: 402 KEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRK------- 454
Query: 783 QALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQR 834
+L+E +++E L+ QLQQE +AY ++ Q Q +++LQK +Q+
Sbjct: 455 ---QLEEQRQSE--RLQRQLQQE----HAYLKSLQQQ---QQQQQLQKQQQQ 494
Score = 39.3 bits (90), Expect = 0.017
Identities = 37/180 (20%), Positives = 73/180 (40%), Gaps = 16/180 (8%)
Query: 705 LRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQLEVTPKNEHK---------TILK 755
+R QP E Q++ Q +D K+ + + E + E + +
Sbjct: 289 IRDQPT-----ERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIM 343
Query: 756 TLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQA--LRLQLQQEMELLNAYQ 813
+ E T + L Q E N Q +L + Q+ + +A L Q++ + +
Sbjct: 344 NVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKE 403
Query: 814 SKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKNLLERQEREIE 873
+ +++ + + ERE +KL+++ RR Q + E Q ER + K ++R+ E
Sbjct: 404 ERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSE 463
Score = 37.7 bits (86), Expect = 0.048
Identities = 30/154 (19%), Positives = 69/154 (44%), Gaps = 9/154 (5%)
Query: 632 REELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNK 691
RE L ++ K A+ + ++ + H L R++ Q E ++E +
Sbjct: 353 REFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQ 412
Query: 692 RRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQLEVTPKNEHK 751
RRERE + E +++ ++++A+ + +++ Q ++ + K QLE ++E
Sbjct: 413 RREREQRKLQEKEQQRRLEDMQALRREEERR-------QAEREQEYKRKQLEEQRQSER- 464
Query: 752 TILKTLKDEQTRKLAILAEQYEQSINEMMASQAL 785
+ + L+ E ++ +Q +Q + + Q L
Sbjct: 465 -LQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLL 497
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 214 bits (544), Expect = 4e-55
Identities = 171/549 (31%), Positives = 263/549 (47%), Gaps = 92/549 (16%)
Query: 13 DLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKE 72
DL DP +F + +G+G++G VY + T ++ AIK M T ++ ++I E
Sbjct: 14 DLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV----TEDEEEEIKLE 69
Query: 73 VKFLRQLKHPNTIE-YKGCYLK------EHTAWLVMEYC-LGSASDLLEVHK-KPLQEVE 123
+ L++ H I Y G ++K + WLVME+C GS +DL++ K L+E
Sbjct: 70 INMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDW 129
Query: 124 IAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPA----NSFV 179
IA I+ L GLA+LH H +IHRDIK N+LLTE +VKL DFG ++ N+F+
Sbjct: 130 IAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFI 189
Query: 180 GTPYWMAPEVILAMDEGQ---YDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQN 236
GTPYWMAPEVI A DE YD + D+WS GIT IE+AE PPL +M+ M AL+ I +N
Sbjct: 190 GTPYWMAPEVI-ACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN 248
Query: 237 DSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVR---RDRPLRV-LIDLIQR 292
P L+S +W+ F F++ CL K +RP++ +LL+H F+R +R +R+ L D I R
Sbjct: 249 PPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDR 308
Query: 293 TKDAVRELDNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPS 352
T+ E D +Y + S+E+EE+ +P
Sbjct: 309 TRKKRGEKDETEYE--------------YSGSEEEEEE-------------------VPE 335
Query: 353 MSVSTGSQSSSVNSMQEVMDESSSELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDP 412
G SS VN EST+ F+R + + +
Sbjct: 336 QE---GEPSSIVNV----------------PGESTLRRD----------FLRLQQENKER 366
Query: 413 RPEPRPTQSVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQ 472
R Q +Q Q L R +E + A R + EQ L EQ + RRQ +
Sbjct: 367 SEALRRQQLLQEQQL--REQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQE 424
Query: 473 KQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKK 532
++ E + K ++E + ++E E + E ++ +++ I ++ + +
Sbjct: 425 REQRRREQEEKRRLEELERRRKEEEE---RRRAEEEKRRVEREQEYIRRQLEEEQRHLEV 481
Query: 533 FQQQILAQQ 541
QQQ+L +Q
Sbjct: 482 LQQQLLQEQ 490
Score = 47.8 bits (112), Expect = 5e-05
Identities = 55/223 (24%), Positives = 93/223 (41%), Gaps = 38/223 (17%)
Query: 689 YNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTK------QYKALKNHQL 742
Y +R E KH +R QP N + + +Q+K T K + + +Y + +
Sbjct: 274 YMQRPSTEQLLKHPF-IRDQP-NERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEE 331
Query: 743 EVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQL 802
EV + + + + E T + L Q E S+ALR + + Q LR Q
Sbjct: 332 EVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKER----SEALRRQQLLQE--QQLREQE 385
Query: 803 QQEMELLNAYQSKIKMQTEAQH--------ERELQKLEQRVSLRRAHLEQKIEEELAALQ 854
+ + +LL Q +I+ Q E + ERE ++ ++R RR E++ EEL +
Sbjct: 386 EYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRR 445
Query: 855 KERSER----------------IKNLLERQEREIETFDMESLR 881
KE ER I+ LE ++R +E + L+
Sbjct: 446 KEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQ 488
Score = 43.9 bits (102), Expect = 7e-04
Identities = 63/284 (22%), Positives = 128/284 (45%), Gaps = 17/284 (5%)
Query: 459 EQMSGYKRMRRQHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAI 518
EQ+ + +R Q ++ + ++ LK +D R K ++ ET S E E+ ++V
Sbjct: 281 EQLLKHPFIRDQPNERQVRIQ--LKDHIDRTRKKRGEKDETEYEYSGSEEEE---EEVPE 335
Query: 519 IEKEAK--VAAADEKKFQQQILAQQKKDLTTFLESQKKQYKICKEKIKEEMNEDHSTPKK 576
E E V E ++ L Q+++ E+ ++Q + +++++E+ E
Sbjct: 336 QEGEPSSIVNVPGESTLRRDFLRLQQENKERS-EALRRQQLLQEQQLREQ-EEYKRQLLA 393
Query: 577 EKQERISKHKENLQHTQAEE--EAHLLTQQRLYYDKNCRFFKRKI--MIKRHEVEQQNIR 632
E+Q+RI + KE + + ++ E QQ + + KR++ + +R + E++ R
Sbjct: 394 ERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRR 453
Query: 633 EELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKR 692
E K+R ++E E+ + +E R LE Q LQ+ M L + +Q +
Sbjct: 454 AEEEKRRVEREQEYIRR-QLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQ 512
Query: 693 RERELHRKHVMELR---QQPKNLKAMEMQIKKQFQDTCKVQTKQ 733
+ER H E + + + +E + +K + + Q+KQ
Sbjct: 513 QERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQ 556
Score = 40.8 bits (94), Expect = 0.006
Identities = 37/147 (25%), Positives = 69/147 (46%), Gaps = 18/147 (12%)
Query: 628 QQNIREELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQL 687
QQ +E R Q+ ++ L +E R+L L QK R++ Q E +L
Sbjct: 360 QQENKERSEALRRQQLLQEQQLREQEEYKRQL----LAERQK------RIEQQKEQRRRL 409
Query: 688 EYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQLEVTPK 747
E +RRERE RQQ + + E + K++ ++ + + ++ + + + + +
Sbjct: 410 EEQQRREREAR-------RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVE 462
Query: 748 NEHKTILKTLKDEQTRKLAILAEQYEQ 774
E + I + L++EQ R L +L +Q Q
Sbjct: 463 REQEYIRRQLEEEQ-RHLEVLQQQLLQ 488
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 214 bits (544), Expect = 4e-55
Identities = 171/549 (31%), Positives = 263/549 (47%), Gaps = 92/549 (16%)
Query: 13 DLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKE 72
DL DP +F + +G+G++G VY + T ++ AIK M T ++ ++I E
Sbjct: 14 DLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV----TEDEEEEIKLE 69
Query: 73 VKFLRQLKHPNTIE-YKGCYLK------EHTAWLVMEYC-LGSASDLLEVHK-KPLQEVE 123
+ L++ H I Y G ++K + WLVME+C GS +DL++ K L+E
Sbjct: 70 INMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDW 129
Query: 124 IAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPA----NSFV 179
IA I+ L GLA+LH H +IHRDIK N+LLTE +VKL DFG ++ N+F+
Sbjct: 130 IAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFI 189
Query: 180 GTPYWMAPEVILAMDEGQ---YDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQN 236
GTPYWMAPEVI A DE YD + D+WS GIT IE+AE PPL +M+ M AL+ I +N
Sbjct: 190 GTPYWMAPEVI-ACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN 248
Query: 237 DSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVR---RDRPLRV-LIDLIQR 292
P L+S +W+ F F++ CL K +RP++ +LL+H F+R +R +R+ L D I R
Sbjct: 249 PPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDR 308
Query: 293 TKDAVRELDNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPS 352
T+ E D +Y + S+E+EE+ +P
Sbjct: 309 TRKKRGEKDETEYE--------------YSGSEEEEEE-------------------VPE 335
Query: 353 MSVSTGSQSSSVNSMQEVMDESSSELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDP 412
G SS VN EST+ F+R + + +
Sbjct: 336 QE---GEPSSIVNV----------------PGESTLRRD----------FLRLQQENKER 366
Query: 413 RPEPRPTQSVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQ 472
R Q +Q Q L R +E + A R + EQ L EQ + RRQ +
Sbjct: 367 SEALRRQQLLQEQQL--REQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQE 424
Query: 473 KQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKK 532
++ E + K ++E + ++E E + E ++ +++ I ++ + +
Sbjct: 425 REQRRREQEEKRRLEELERRRKEEEE---RRRAEEEKRRVEREQEYIRRQLEEEQRHLEV 481
Query: 533 FQQQILAQQ 541
QQQ+L +Q
Sbjct: 482 LQQQLLQEQ 490
Score = 47.8 bits (112), Expect = 5e-05
Identities = 55/223 (24%), Positives = 93/223 (41%), Gaps = 38/223 (17%)
Query: 689 YNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTK------QYKALKNHQL 742
Y +R E KH +R QP N + + +Q+K T K + + +Y + +
Sbjct: 274 YMQRPSTEQLLKHPF-IRDQP-NERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEE 331
Query: 743 EVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQL 802
EV + + + + E T + L Q E S+ALR + + Q LR Q
Sbjct: 332 EVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKER----SEALRRQQLLQE--QQLREQE 385
Query: 803 QQEMELLNAYQSKIKMQTEAQH--------ERELQKLEQRVSLRRAHLEQKIEEELAALQ 854
+ + +LL Q +I+ Q E + ERE ++ ++R RR E++ EEL +
Sbjct: 386 EYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRR 445
Query: 855 KERSER----------------IKNLLERQEREIETFDMESLR 881
KE ER I+ LE ++R +E + L+
Sbjct: 446 KEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQ 488
Score = 42.0 bits (97), Expect = 0.003
Identities = 52/220 (23%), Positives = 104/220 (47%), Gaps = 14/220 (6%)
Query: 459 EQMSGYKRMRRQHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAI 518
EQ+ + +R Q ++ + ++ LK +D R K ++ ET S E E+ ++V
Sbjct: 281 EQLLKHPFIRDQPNERQVRIQ--LKDHIDRTRKKRGEKDETEYEYSGSEEEE---EEVPE 335
Query: 519 IEKEAK--VAAADEKKFQQQILAQQKKDLTTFLESQKKQYKICKEKIKEEMNEDHSTPKK 576
E E V E ++ L Q+++ E+ ++Q + +++++E+ E
Sbjct: 336 QEGEPSSIVNVPGESTLRRDFLRLQQENKERS-EALRRQQLLQEQQLREQ-EEYKRQLLA 393
Query: 577 EKQERISKHKENLQHTQAEE--EAHLLTQQRLYYDKNCRFFKRKI--MIKRHEVEQQNIR 632
E+Q+RI + KE + + ++ E QQ + + KR++ + +R + E++ R
Sbjct: 394 ERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRR 453
Query: 633 EELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRM 672
E K+R ++E E+ + +E R LE Q LQ+ M
Sbjct: 454 AEEEKRRVEREQEYIRR-QLEEEQRHLEVLQQQLLQEQAM 492
Score = 40.8 bits (94), Expect = 0.006
Identities = 37/147 (25%), Positives = 69/147 (46%), Gaps = 18/147 (12%)
Query: 628 QQNIREELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQL 687
QQ +E R Q+ ++ L +E R+L L QK R++ Q E +L
Sbjct: 360 QQENKERSEALRRQQLLQEQQLREQEEYKRQL----LAERQK------RIEQQKEQRRRL 409
Query: 688 EYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQLEVTPK 747
E +RRERE RQQ + + E + K++ ++ + + ++ + + + + +
Sbjct: 410 EEQQRREREAR-------RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVE 462
Query: 748 NEHKTILKTLKDEQTRKLAILAEQYEQ 774
E + I + L++EQ R L +L +Q Q
Sbjct: 463 REQEYIRRQLEEEQ-RHLEVLQQQLLQ 488
Score = 40.4 bits (93), Expect = 0.007
Identities = 40/181 (22%), Positives = 87/181 (48%), Gaps = 18/181 (9%)
Query: 550 ESQKKQYKIC-KEKIKEEMNEDHSTPKKE---------KQERISKHKENLQHTQAEEEAH 599
E + +Y+ E+ +EE+ E P +++ + +EN + ++A
Sbjct: 315 EKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQ 374
Query: 600 LLTQQRLYYDKNCRFFKRKIMIKRHE-VEQQNIREELNKKRTQKEMEHAMLIRHDESTRE 658
LL +Q+L + +KR+++ +R + +EQQ + +++ ++E E ++ RE
Sbjct: 375 LLQEQQLREQEE---YKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRRE 431
Query: 659 LEY-RQLHTLQKLRMDLIRLQHQTELENQLEYNK---RRERELHRKHVMELRQQPKNLKA 714
E R+L L++ R + + E + ++E + RR+ E ++H+ L+QQ +A
Sbjct: 432 QEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQA 491
Query: 715 M 715
M
Sbjct: 492 M 492
Score = 38.9 bits (89), Expect = 0.022
Identities = 40/179 (22%), Positives = 84/179 (46%), Gaps = 39/179 (21%)
Query: 427 LHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQLIALENKLKAEM 486
L N+ER ++ L+ QE +LREQ ++++QL+A K +
Sbjct: 359 LQQENKERSEALRRQQLL--------QEQQLREQ--------EEYKRQLLAERQKRIEQQ 402
Query: 487 DEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQQILAQQKKDLT 546
E R +L+++ E+ A++Q E+E + +EK+ +++ ++K++
Sbjct: 403 KEQRRRLEEQQRR---------EREARRQQ---EREQRRREQEEKRRLEELERRRKEE-- 448
Query: 547 TFLESQKKQYKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEEEAHLLTQQR 605
+++ + +EK + E +++ + E+++R H E LQ +E+A LL R
Sbjct: 449 ------EERRRAEEEKRRVEREQEYIRRQLEEEQR---HLEVLQQQLLQEQAMLLHDHR 498
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 209 bits (533), Expect = 7e-54
Identities = 114/285 (40%), Positives = 174/285 (61%), Gaps = 12/285 (4%)
Query: 19 DPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQ 78
+P+E F + IG G++G VY A N +T E+ AIK + + E + + +E+ ++
Sbjct: 11 NPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKL---EPGEDFAVVQQEIIMMKD 67
Query: 79 LKHPNTIEYKGCYLKEHTAWLVMEYCLG-SASDLLEVHKKPLQEVEIAAITHGALHGLAY 137
KHPN + Y G YL+ W+ ME+C G S D+ V PL E++IA ++ L GL Y
Sbjct: 68 CKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHV-TGPLSELQIAYVSRETLQGLYY 126
Query: 138 LHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPA----NSFVGTPYWMAPEVILAM 193
LHS +HRDIK NILLT+ G VKLADFG ++ + SF+GTPYWMAPEV
Sbjct: 127 LHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVE 186
Query: 194 DEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQND--SPTLQSN-EWTDSF 250
+G Y+ D+W++GIT IELAE +PP+F+++ M AL+ + +++ P L+ +W++SF
Sbjct: 187 RKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSF 246
Query: 251 RRFVDYCLQKIPQERPTSAELLRHDFVRRDRPLRVLIDLIQRTKD 295
FV L K P++RPT+ +LL+H FV + + I+L+ + +
Sbjct: 247 HHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNN 291
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 207 bits (527), Expect = 4e-53
Identities = 129/374 (34%), Positives = 195/374 (52%), Gaps = 21/374 (5%)
Query: 19 DPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQ 78
DP + F L +G G++G VY A + TSE+ A+K + Q +E+ LR+
Sbjct: 11 DPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQ---QEITILRE 67
Query: 79 LKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALHGLAYL 138
+HPN + Y G YL+ W+ ME+C G + + PL+E +IA + AL GL +L
Sbjct: 68 CRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHHL 127
Query: 139 HSHALIHRDIKAGNILLTEPGQVKLADFG-----SASMASPANSFVGTPYWMAPEVILAM 193
HS IHRDIK N+LLT G VKLADFG +AS+A SF+GTPYWMAPEV
Sbjct: 128 HSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAK-RRSFIGTPYWMAPEVAAVE 186
Query: 194 DEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQN--DSPTLQ-SNEWTDSF 250
+G Y+ D+W+LGIT IEL E +PPLF+++ M AL ++++ P L+ WT +F
Sbjct: 187 RKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNF 246
Query: 251 RRFVDYCLQKIPQERPTSAELLRHDFVRRDRPLRVLIDLIQRTKD------AVRELDNLQ 304
F+ L K P++RPT+ +LL+H F + P +L L+ + D + + +
Sbjct: 247 HHFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLLDKASDPHLGTPSPEDCELET 306
Query: 305 YRKMKKILFQETRNGPLNESQEDEE--DSEHGTSLNREMDSLGSNHSIPSMSVSTGSQSS 362
Y + ++GP + + + + G +E D L + S
Sbjct: 307 YDMFPDTIHSRGQHGPAERTPSEIQFHQVKFGAPRRKETDPLNEPWEEEWTLLGKEELSG 366
Query: 363 S-VNSMQEVMDESS 375
S + S+QE ++E S
Sbjct: 367 SLLQSVQEALEERS 380
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 201 bits (512), Expect = 2e-51
Identities = 112/286 (39%), Positives = 170/286 (59%), Gaps = 13/286 (4%)
Query: 19 DPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQ 78
+P++ + + +G G++G VY A N HT E+ A+K + + + + I +E+ +++
Sbjct: 15 NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKL---EPGDDFSLIQQEIFMVKE 71
Query: 79 LKHPNTIEYKGCYLKEHTAWLVMEYCLG-SASDLLEVHKKPLQEVEIAAITHGALHGLAY 137
KH N + Y G YL W+ MEYC G S D+ V PL E++IA + L GLAY
Sbjct: 72 CKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHV-TGPLSELQIAYVCRETLQGLAY 130
Query: 138 LHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPA----NSFVGTPYWMAPEVILAM 193
LH+ +HRDIK NILLT+ G VKLADFG A+ + SF+GTPYWMAPEV
Sbjct: 131 LHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVE 190
Query: 194 DEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQND--SPTLQ-SNEWTDSF 250
G Y+ DIW++GIT IEL E +PP+F+++ M AL+ +++++ P L+ +W+ +F
Sbjct: 191 KNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTF 250
Query: 251 RRFVDYCLQKIPQERPTSAELLRHDFVRRDRPLRVL-IDLIQRTKD 295
FV L K P++RPT+ LL H FV + R L ++L+ + +
Sbjct: 251 HNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNN 296
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.128 0.355
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,285,792
Number of Sequences: 37866
Number of extensions: 1480697
Number of successful extensions: 21389
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 828
Number of HSP's successfully gapped in prelim test: 1285
Number of HSP's that attempted gapping in prelim test: 9125
Number of HSP's gapped (non-prelim): 6584
length of query: 898
length of database: 18,247,518
effective HSP length: 111
effective length of query: 787
effective length of database: 14,044,392
effective search space: 11052936504
effective search space used: 11052936504
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.