Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 148664209
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148664209 kelch-like 10 [Homo sapiens]
(608 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148664209 kelch-like 10 [Homo sapiens] 1256 0.0
gi|40807500 kelch-like 20 [Homo sapiens] 369 e-102
gi|166235129 kelch-like 3 [Homo sapiens] 360 2e-99
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 358 6e-99
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 358 6e-99
gi|11056006 kelch-like 12 [Homo sapiens] 350 2e-96
gi|38194229 kelch-like 17 [Homo sapiens] 346 4e-95
gi|14780904 kelch-like 1 protein [Homo sapiens] 328 9e-90
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 328 1e-89
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 328 1e-89
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 325 1e-88
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 322 8e-88
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 316 3e-86
gi|55925604 kelch-like 18 [Homo sapiens] 316 3e-86
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 314 1e-85
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 313 3e-85
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 305 8e-83
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 305 8e-83
gi|34101268 kelch-like 8 [Homo sapiens] 285 1e-76
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 259 5e-69
gi|223890235 intracisternal A particle-promoted polypeptide isof... 253 4e-67
gi|40018614 DRE1 protein [Homo sapiens] 252 6e-67
gi|45643138 kelch-like 13 [Homo sapiens] 242 8e-64
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 238 1e-62
gi|24308181 kelch-like 9 [Homo sapiens] 237 3e-62
gi|109150407 kelch-like 6 [Homo sapiens] 235 8e-62
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens] 233 3e-61
gi|40255071 kelch-like 23 [Homo sapiens] 233 3e-61
gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 221 2e-57
gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain contai... 221 2e-57
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 1256 bits (3251), Expect = 0.0
Identities = 608/608 (100%), Positives = 608/608 (100%)
Query: 1 MEMESAAASTRFHQPHMERKMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSC 60
MEMESAAASTRFHQPHMERKMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSC
Sbjct: 1 MEMESAAASTRFHQPHMERKMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSC 60
Query: 61 SSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFN 120
SSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFN
Sbjct: 61 SSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFN 120
Query: 121 IMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLE 180
IMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLE
Sbjct: 121 IMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLE 180
Query: 181 LSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFM 240
LSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFM
Sbjct: 181 LSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFM 240
Query: 241 NNVKMNDYVKDSEECKPVIINALKAMYDLNMNGPSNSDFTNPLTRPRLPYAILFAIGGWS 300
NNVKMNDYVKDSEECKPVIINALKAMYDLNMNGPSNSDFTNPLTRPRLPYAILFAIGGWS
Sbjct: 241 NNVKMNDYVKDSEECKPVIINALKAMYDLNMNGPSNSDFTNPLTRPRLPYAILFAIGGWS 300
Query: 301 GGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFD 360
GGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFD
Sbjct: 301 GGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFD 360
Query: 361 PVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMH 420
PVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMH
Sbjct: 361 PVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMH 420
Query: 421 EQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGE 480
EQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGE
Sbjct: 421 EQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGE 480
Query: 481 HVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTT 540
HVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTT
Sbjct: 481 HVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTT 540
Query: 541 TFNVECYDEKTDEWYDAHDMSIYRSALSCCVVPGLANVEEYAARRDNFPGLALRDEVKYS 600
TFNVECYDEKTDEWYDAHDMSIYRSALSCCVVPGLANVEEYAARRDNFPGLALRDEVKYS
Sbjct: 541 TFNVECYDEKTDEWYDAHDMSIYRSALSCCVVPGLANVEEYAARRDNFPGLALRDEVKYS 600
Query: 601 ASTSTLPV 608
ASTSTLPV
Sbjct: 601 ASTSTLPV 608
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 369 bits (948), Expect = e-102
Identities = 205/544 (37%), Positives = 292/544 (53%), Gaps = 10/544 (1%)
Query: 15 PHMERKMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNN 74
P++ K E+ N LR +LCDVV+ V + AH+ IL +CS YFRA+FT
Sbjct: 44 PYISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAE 103
Query: 75 TEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKS 134
+ + I I M+L+I++AYT + + NV+ LL AA + I CCEFLK
Sbjct: 104 SRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKR 163
Query: 135 ELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDE 194
+L NC+GI F D + C EL + A F HNF+E+++ S EF+ L +L DII DE
Sbjct: 164 QLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVME-SEEFMLLPANQLIDIISSDE 222
Query: 195 LNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEE 254
LNV+ E+ VF A++ W+ + Q R+ + +L VRL L+ ++ + V + +K EE
Sbjct: 223 LNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEE 282
Query: 255 CKPVIINALKAMYDLNMNGPSNSDFTNPLTRPRLPYA---ILFAIGGWSGGSPTNAIEAY 311
C+ ++ A + L P P TRPR P +LFA+GGW G +++E Y
Sbjct: 283 CRDLVDEAKNYLL-LPQERPL---MQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERY 338
Query: 312 DARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQ-VA 370
D + + W + R G + L +Y +GG D Y NSV+R+DP W VA
Sbjct: 339 DPQTNEW-RMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVA 397
Query: 371 PMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATT 430
P + R V V VLG F+YA+GG DG LN ERY+P+ N+WT +A M +R +
Sbjct: 398 PTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAV 457
Query: 431 LYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDG 490
L G +Y GG +G L T E YN + N+W IAPM +RR +G Y + +YAVGG D
Sbjct: 458 LGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDD 517
Query: 491 ANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEK 550
L SAE Y+P N W + M + RS G+ VV+ L VGGF+G T +E +D
Sbjct: 518 TTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPD 577
Query: 551 TDEW 554
+ W
Sbjct: 578 ANTW 581
Score = 31.2 bits (69), Expect = 2.9
Identities = 17/49 (34%), Positives = 25/49 (51%)
Query: 527 DLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVVPGL 575
++LF VGG+ +VE YD +T+EW MS R + V+ L
Sbjct: 318 EVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDL 366
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 360 bits (924), Expect = 2e-99
Identities = 193/535 (36%), Positives = 297/535 (55%), Gaps = 11/535 (2%)
Query: 25 ACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPG 84
A ++ NELR + LCDV+I E AH+ +L +CS YF A+FT + ++ K I
Sbjct: 36 AFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKD 95
Query: 85 ISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGI 144
+ + +I+Y YT + +T +NV+ LL AA +M + + CC+FL+S+L NC+GI
Sbjct: 96 VDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGI 155
Query: 145 CKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVF 204
F D + C +L Q+A + +F E V + EFL LS+ ++ +I D+L V E+ VF
Sbjct: 156 RAFADVHTCTDLLQQANAYAEQHFPE-VMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVF 214
Query: 205 EAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALK 264
EA++ WI+++ + R +H++ L+ VRL L+ +Y + V+ +K++ CK +I A+K
Sbjct: 215 EAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMK 274
Query: 265 AMYDLNMNGPSNSDFTNPLTRPRLPYA---ILFAIGGWSGGSPTNAIEAYDARADRWVNV 321
Y L + NP T+PR P + ++ +GG ++E YD DRW +
Sbjct: 275 --YHL-LPLDQRLLIKNPRTKPRTPVSLPKVMIVVGG-QAPKAIRSVECYDFEEDRWDQI 330
Query: 322 TCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSV 381
E S R G ++ G+VY +GGF+ +V +D VK W +A M RR +
Sbjct: 331 -AELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGA 389
Query: 382 TVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGF 441
VL + +YA+GGFDG L + E Y +TN+W +APM+ +RS + GK+Y GG+
Sbjct: 390 AVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGY 449
Query: 442 NG--NECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEA 499
+G +CL T E YN +N+W +A M +RRSG GV +YA GG DG +S E
Sbjct: 450 DGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVEV 509
Query: 500 YSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEW 554
Y P NTW+ + M R N G+ V+ LL+VVGG +G +VE Y+ TD+W
Sbjct: 510 YDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKW 564
Score = 109 bits (272), Expect = 8e-24
Identities = 57/141 (40%), Positives = 83/141 (58%)
Query: 434 KVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANR 493
KV I G + + + E Y+ E ++W IA + SRR GV+ HVYAVGGF+G+ R
Sbjct: 301 KVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLR 360
Query: 494 LRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDE 553
+R+ + Y V + W +I +M RS G V++DLL+ VGGF+G T +VE Y KT+E
Sbjct: 361 VRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNE 420
Query: 554 WYDAHDMSIYRSALSCCVVPG 574
W+ M+ RS++ VV G
Sbjct: 421 WFFVAPMNTRRSSVGVGVVEG 441
Score = 29.6 bits (65), Expect = 8.4
Identities = 12/46 (26%), Positives = 23/46 (50%)
Query: 292 ILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYL 337
+L+ +GG G ++E Y+ D+W + + R+Y G A +
Sbjct: 538 LLYVVGGDDGSCNLASVEYYNPVTDKWTLLPTNMSTGRSYAGVAVI 583
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 358 bits (920), Expect = 6e-99
Identities = 202/562 (35%), Positives = 304/562 (54%), Gaps = 20/562 (3%)
Query: 3 MESAAASTRFHQP------HMERKMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNI 56
++S +T H P HM++ A ++ NELR + LCDV I E SAH+ +
Sbjct: 23 LDSKDDNTEKHCPVTVNPWHMKK-----AFKVMNELRSQNLLCDVTIVAEDMEISAHRVV 77
Query: 57 LCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAA 116
L +CS YF A+FT + + K I + ++++I+Y YT + +T +NV+ LL AA
Sbjct: 78 LAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAA 137
Query: 117 DQFNIMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSA 176
+ + + CCEFL+S+L NC+GI F D + C +L KA + +F ++V +S
Sbjct: 138 GLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVV-LSE 196
Query: 177 EFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHA 236
EFL L + ++ +I D+L + E+ VFEA++ W++HD R++ ++ L+ VRL L+
Sbjct: 197 EFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPR 256
Query: 237 EYFMNNVKMNDYVKDSEECKPVIINALKAMYDLNMNGPSNSDFTNPLTRPRLPYAI--LF 294
EY + V+ VK+S CK +I A+K Y L + + TR R P + L
Sbjct: 257 EYLVQRVEEEALVKNSSACKDYLIEAMK--YHL-LPTEQRILMKSVRTRLRTPMNLPKLM 313
Query: 295 AIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFN 354
+ G ++E YD + +RW V E S R G Y+ G V+ +GGF+
Sbjct: 314 VVVGGQAPKAIRSVECYDFKEERWHQV-AELPSRRCRAGMVYMAGLVFAVGGFNGSLRVR 372
Query: 355 SVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWT 414
+V +DPVK W VA M RR + VL +YA+GGFDG L++ E Y ++N+W
Sbjct: 373 TVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWF 432
Query: 415 LIAPMHEQRSDASATTLYGKVYICGGFNG--NECLFTAEVYNTESNQWTVIAPMRSRRSG 472
+APM+ +RS + G +Y GG++G +CL T E YN +N+WT IA M +RRSG
Sbjct: 433 HVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSG 492
Query: 473 IGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVV 532
GV +YAVGG DG +S E Y P N WR + M R N G+ V+ LL+VV
Sbjct: 493 AGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVV 552
Query: 533 GGFNGFTTTFNVECYDEKTDEW 554
GG +G +VE Y+ TD+W
Sbjct: 553 GGDDGSCNLASVEYYNPTTDKW 574
Score = 99.4 bits (246), Expect = 9e-21
Identities = 49/142 (34%), Positives = 84/142 (59%)
Query: 434 KVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANR 493
K+ + G + + + E Y+ + +W +A + SRR G++ V+AVGGF+G+ R
Sbjct: 311 KLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLR 370
Query: 494 LRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDE 553
+R+ ++Y PV + W ++ M + RS G V++ LL+ VGGF+G T +VE Y+ K++E
Sbjct: 371 VRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNE 430
Query: 554 WYDAHDMSIYRSALSCCVVPGL 575
W+ M+ RS++ VV GL
Sbjct: 431 WFHVAPMNTRRSSVGVGVVGGL 452
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 358 bits (920), Expect = 6e-99
Identities = 202/562 (35%), Positives = 304/562 (54%), Gaps = 20/562 (3%)
Query: 3 MESAAASTRFHQP------HMERKMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNI 56
++S +T H P HM++ A ++ NELR + LCDV I E SAH+ +
Sbjct: 19 LDSKDDNTEKHCPVTVNPWHMKK-----AFKVMNELRSQNLLCDVTIVAEDMEISAHRVV 73
Query: 57 LCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAA 116
L +CS YF A+FT + + K I + ++++I+Y YT + +T +NV+ LL AA
Sbjct: 74 LAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAA 133
Query: 117 DQFNIMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSA 176
+ + + CCEFL+S+L NC+GI F D + C +L KA + +F ++V +S
Sbjct: 134 GLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVV-LSE 192
Query: 177 EFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHA 236
EFL L + ++ +I D+L + E+ VFEA++ W++HD R++ ++ L+ VRL L+
Sbjct: 193 EFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPR 252
Query: 237 EYFMNNVKMNDYVKDSEECKPVIINALKAMYDLNMNGPSNSDFTNPLTRPRLPYAI--LF 294
EY + V+ VK+S CK +I A+K Y L + + TR R P + L
Sbjct: 253 EYLVQRVEEEALVKNSSACKDYLIEAMK--YHL-LPTEQRILMKSVRTRLRTPMNLPKLM 309
Query: 295 AIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFN 354
+ G ++E YD + +RW V E S R G Y+ G V+ +GGF+
Sbjct: 310 VVVGGQAPKAIRSVECYDFKEERWHQV-AELPSRRCRAGMVYMAGLVFAVGGFNGSLRVR 368
Query: 355 SVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWT 414
+V +DPVK W VA M RR + VL +YA+GGFDG L++ E Y ++N+W
Sbjct: 369 TVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWF 428
Query: 415 LIAPMHEQRSDASATTLYGKVYICGGFNG--NECLFTAEVYNTESNQWTVIAPMRSRRSG 472
+APM+ +RS + G +Y GG++G +CL T E YN +N+WT IA M +RRSG
Sbjct: 429 HVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSG 488
Query: 473 IGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVV 532
GV +YAVGG DG +S E Y P N WR + M R N G+ V+ LL+VV
Sbjct: 489 AGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVV 548
Query: 533 GGFNGFTTTFNVECYDEKTDEW 554
GG +G +VE Y+ TD+W
Sbjct: 549 GGDDGSCNLASVEYYNPTTDKW 570
Score = 99.4 bits (246), Expect = 9e-21
Identities = 49/142 (34%), Positives = 84/142 (59%)
Query: 434 KVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANR 493
K+ + G + + + E Y+ + +W +A + SRR G++ V+AVGGF+G+ R
Sbjct: 307 KLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLR 366
Query: 494 LRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDE 553
+R+ ++Y PV + W ++ M + RS G V++ LL+ VGGF+G T +VE Y+ K++E
Sbjct: 367 VRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNE 426
Query: 554 WYDAHDMSIYRSALSCCVVPGL 575
W+ M+ RS++ VV GL
Sbjct: 427 WFHVAPMNTRRSSVGVGVVGGL 448
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 350 bits (899), Expect = 2e-96
Identities = 187/548 (34%), Positives = 295/548 (53%), Gaps = 11/548 (2%)
Query: 30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDM 89
N LR LCDV ++V +F AH+ +L +CS YF A+FTS + K +I G++
Sbjct: 24 NSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYVDIQGLTAST 83
Query: 90 MKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTD 149
M++++++ YT TV +T +NV++LL AA + G+ + CCEFL+S+L NC+GI F +
Sbjct: 84 MEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNCLGIRDFAE 143
Query: 150 YYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILK 209
+ C +L Q A +F +F E+V+ EF+ LS E++ +I+ DE+ V E+ VFEA++
Sbjct: 144 THNCVDLMQAAEVFSQKHFPEVVQ-HEEFILLSQGEVEKLIKCDEIQVDSEEPVFEAVIN 202
Query: 210 WISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMYDL 269
W+ H + R++ + LL VR+ L+ Y + + +++ S +C+ ++ A K
Sbjct: 203 WVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDEAKK----F 258
Query: 270 NMNGPSNSDFTNPLTRPRL-PYAILFAIGGW-SGGSPTNAIEAYDARADRWVNVTCEEES 327
++ S P TR RL +L +GG+ S SP + +E YD + W +
Sbjct: 259 HLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRK 318
Query: 328 PRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKK---TWHQVAPMHSRRCYVSVTVL 384
R Y + L +Y+IGG+D +SV+ D W+ VAPM+ RR T L
Sbjct: 319 -RRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTL 377
Query: 385 GNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGN 444
G+ IY GGFDG R + ERY+P +QW+++ M R A G +Y GG++G
Sbjct: 378 GDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGL 437
Query: 445 ECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVA 504
L + E Y+ + WT + PM ++RSG GV +H+Y VGGFDG L S EAY+
Sbjct: 438 NILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRT 497
Query: 505 NTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYR 564
++W T+ +M PR G V+ L+ + G++G + ++ECYD D W M R
Sbjct: 498 DSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQR 557
Query: 565 SALSCCVV 572
CV+
Sbjct: 558 CDAGVCVL 565
Score = 124 bits (310), Expect = 3e-28
Identities = 60/189 (31%), Positives = 99/189 (52%), Gaps = 1/189 (0%)
Query: 292 ILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVD 351
+++ GG+ G ++E YD D+W ++ + ++ R G G +Y +GG+D ++
Sbjct: 380 MIYVSGGFDGSRRHTSMERYDPNIDQW-SMLGDMQTAREGAGLVVASGVIYCLGGYDGLN 438
Query: 352 YFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETN 411
NSV+++DP W V PM ++R V +L + IY +GGFDG L++ E Y T+
Sbjct: 439 ILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTD 498
Query: 412 QWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRS 471
WT + M R AT L G++Y G++GN L + E Y+ + W V+ M ++R
Sbjct: 499 SWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQRC 558
Query: 472 GIGVIAYGE 480
GV E
Sbjct: 559 DAGVCVLRE 567
Score = 101 bits (252), Expect = 2e-21
Identities = 49/143 (34%), Positives = 79/143 (55%), Gaps = 1/143 (0%)
Query: 292 ILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVD 351
+++ +GG+ G + N++E YD W NVT + R+ G A L ++Y++GGFD
Sbjct: 427 VIYCLGGYDGLNILNSVEKYDPHTGHWTNVT-PMATKRSGAGVALLNDHIYVVGGFDGTA 485
Query: 352 YFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETN 411
+ +SV+ ++ +W V M + RCYV TVL +YA+ G+DG L++ E Y+P +
Sbjct: 486 HLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIID 545
Query: 412 QWTLIAPMHEQRSDASATTLYGK 434
W ++ M QR DA L K
Sbjct: 546 SWEVVTSMGTQRCDAGVCVLREK 568
Score = 71.2 bits (173), Expect = 3e-12
Identities = 37/143 (25%), Positives = 68/143 (47%), Gaps = 4/143 (2%)
Query: 437 ICGGFNGNEC-LFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLR 495
+ GGF + + E Y+ ++ +W+ + + +R + ++ + +Y +GG+DG +RL
Sbjct: 285 VVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLS 344
Query: 496 SAEAYSPVAN---TWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTD 552
S E A+ W ++ M R G + D+++V GGF+G ++E YD D
Sbjct: 345 SVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNID 404
Query: 553 EWYDAHDMSIYRSALSCCVVPGL 575
+W DM R V G+
Sbjct: 405 QWSMLGDMQTAREGAGLVVASGV 427
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 346 bits (887), Expect = 4e-95
Identities = 187/543 (34%), Positives = 291/543 (53%), Gaps = 3/543 (0%)
Query: 30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDM 89
+ +R G LCD+V+ V E AHK +L SCS YF A+FT+ + + + + I P
Sbjct: 83 SRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQA 142
Query: 90 MKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTD 149
+ ++++AYT + + NV+ LL AA + G+ CC+FL S+L NC+GI F D
Sbjct: 143 LDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFAD 202
Query: 150 YYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILK 209
+ C +L + A+ ++L +F ++ K EF+ L + ++ +++ D LNV E+ V+ A+L
Sbjct: 203 AHSCSDLLKAAHRYVLQHFVDVAKTE-EFMLLPLKQVLELVSSDSLNVPSEEEVYRAVLS 261
Query: 210 WISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMYDL 269
W+ HD R+QH+ L+ VRL L+ ++ + +V V+ +CK ++I ALK
Sbjct: 262 WVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLLP 321
Query: 270 NMNGPSNSDFTNPLTRPRLPYAILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPR 329
G + T P R +LFA+GG S + EAYD R DRW +V + R
Sbjct: 322 EQRGVLGTSRTRP-RRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRW-HVVASMSTRR 379
Query: 330 AYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIY 389
A G A + +Y +GG+D +V+ +DPV TW M +RR + V L +Y
Sbjct: 380 ARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLY 439
Query: 390 AMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFT 449
+ GG+DG LN+AERY+P T WT +A M +R TL G +Y GG++ + L T
Sbjct: 440 SAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLAT 499
Query: 450 AEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTWRT 509
E Y + N W+ +A M SRRS GV +Y GG DG + L S E YSP A W +
Sbjct: 500 VEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWES 559
Query: 510 IPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSC 569
+ M RS + +D L+ VGG +G ++ ++E Y+ +T++W A M RS++
Sbjct: 560 VAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGV 619
Query: 570 CVV 572
V+
Sbjct: 620 AVL 622
Score = 53.9 bits (128), Expect = 4e-07
Identities = 30/97 (30%), Positives = 44/97 (45%)
Query: 479 GEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGF 538
G ++AVGG EAY + W + +M R+ G+ V + L+ VGG++G
Sbjct: 341 GPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGT 400
Query: 539 TTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVVPGL 575
+ VE YD T+ W M RS L + GL
Sbjct: 401 SDLATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGL 437
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 328 bits (841), Expect = 9e-90
Identities = 189/576 (32%), Positives = 308/576 (53%), Gaps = 22/576 (3%)
Query: 6 AAASTRFHQP--HMERKMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSY 63
+++S F+Q H E+ M + + +LCDV++ V + AH+ +L S S Y
Sbjct: 182 SSSSEEFYQAVHHAEQTFRKMESYLKQQ-----QLCDVILIVGNRKIPAHRLVLSSVSDY 236
Query: 64 FRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMG 123
F A+FTS +++ + GI P+ + ++++AYT + + D +E LLAAA +
Sbjct: 237 FAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQ 296
Query: 124 IVRGCCEFLKSELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSV 183
+V CC FL L NC+GI F D C EL + A+ + + N E+++ + EFL L
Sbjct: 297 VVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIR-NQEFLLLPA 355
Query: 184 TELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNV 243
EL ++ D++NV E+ +F A++ W+ +D Q+R +S+LL +RL L+ + + ++
Sbjct: 356 EELHKLLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQ-ILADL 414
Query: 244 KMNDYVKDSEECKPVIINALKAMYDLNMNGPSNSDFTNPLTRPRLP-YAILFAIGGWSGG 302
+ + K+ EC+ +I+ A+K ++ + +P T+PR L+A+GG
Sbjct: 415 ENHALFKNDLECQKLILEAMK----YHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNN 470
Query: 303 SPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPV 362
IE YD R + W+ R G A + +++IGG D + N+V+ ++P
Sbjct: 471 KGATTIEKYDLRTNLWIQAGMMN-GRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPK 529
Query: 363 KKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQ 422
KTW + PM + R + VTVL IYA+GG DG+ LNT ER++P++ QWT +A M
Sbjct: 530 TKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIA 589
Query: 423 RSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHV 482
RS L GK+Y GG +G+ CL + E Y+ +N+W + APM RR G+GV +
Sbjct: 590 RSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFL 649
Query: 483 YAVGGFDG------ANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFN 536
YAVGG D + L E Y P +TW + + PR G+ ++ D L+ VGG++
Sbjct: 650 YAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYD 709
Query: 537 GFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVV 572
G T +E YD +T+EW ++I R+ +C VV
Sbjct: 710 GQTYLNTMESYDPQTNEWTQMASLNIGRAG-ACVVV 744
Score = 98.2 bits (243), Expect = 2e-20
Identities = 53/148 (35%), Positives = 83/148 (56%), Gaps = 13/148 (8%)
Query: 293 LFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDS--- 349
L+++GG G S +++E YD ++W N+ R G A G++Y +GG D+
Sbjct: 602 LYSVGGRDGSSCLSSMEYYDPHTNKW-NMCAPMCKRRGGVGVATCDGFLYAVGGHDAPAS 660
Query: 350 ------VDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTA 403
+DY V+R+DP TW VAP+ R V V +LG+ +YA+GG+DG LNT
Sbjct: 661 NHCSRLLDY---VERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTM 717
Query: 404 ERYEPETNQWTLIAPMHEQRSDASATTL 431
E Y+P+TN+WT +A ++ R+ A +
Sbjct: 718 ESYDPQTNEWTQMASLNIGRAGACVVVI 745
Score = 91.7 bits (226), Expect = 2e-18
Identities = 47/156 (30%), Positives = 76/156 (48%), Gaps = 1/156 (0%)
Query: 419 MHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAY 478
M R+ +T+ G +Y GG + N+ T E Y+ +N W M RR GV
Sbjct: 446 MQSPRTKPRKSTV-GTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVI 504
Query: 479 GEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGF 538
+ ++ +GG DG L + E Y+P TW +P M R G+ V++ ++ VGG +G+
Sbjct: 505 DDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGW 564
Query: 539 TTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVVPG 574
+ VE +D ++ +W MSI RS + + G
Sbjct: 565 SYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNG 600
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 328 bits (840), Expect = 1e-89
Identities = 178/543 (32%), Positives = 292/543 (53%), Gaps = 16/543 (2%)
Query: 37 KLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEY 96
+LCDV++ AH+ +L S S YF A+FT+ ++ + G+ P+ + +I+Y
Sbjct: 172 QLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQY 231
Query: 97 AYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPEL 156
AYT + + DN+E LL+ A + +V CC+FL +L NC+GI F D C +L
Sbjct: 232 AYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDL 291
Query: 157 RQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQ 216
+ A+ + + +F E+++ + EF+ L +E+ ++ D++N+ E+ + A+L W+ HD +
Sbjct: 292 HKVAHNYTMEHFMEVIR-NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLE 350
Query: 217 NRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMYDLNMNGPSN 276
R++ +S LL +RL L+ A F+ +++ N +D EC+ +I+ A+K ++
Sbjct: 351 QRRKDLSKLLAYIRLPLL-APQFLADMENNVLFRDDIECQKLIMEAMK----YHLLPERR 405
Query: 277 SDFTNPLTRPRLP-YAILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAA 335
+P T+PR LFA+GG +IE YD R + W V R G A
Sbjct: 406 PMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVA-NMNGRRLQFGVA 464
Query: 336 YLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFD 395
L +Y++GG D + N+V+ ++P KTW + PM + R + V VL +YA+GG D
Sbjct: 465 VLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHD 524
Query: 396 GYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNT 455
G+ LNT ER++P+ QW +A M RS L GK+Y GG +G+ CL + E ++
Sbjct: 525 GWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDP 584
Query: 456 ESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDG-ANRLRS-----AEAYSPVANTWRT 509
+N+WT+ A M RR G+GV + +YA+GG D A+ L S E Y P + W
Sbjct: 585 HTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTA 644
Query: 510 IPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSC 569
+ +M R G+ ++ D L+ VGG++G VE YD +T+EW + + R+
Sbjct: 645 VASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRA--GA 702
Query: 570 CVV 572
CVV
Sbjct: 703 CVV 705
Score = 131 bits (330), Expect = 2e-30
Identities = 67/188 (35%), Positives = 101/188 (53%)
Query: 388 IYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECL 447
++A+GG D + E+Y+ TN WT +A M+ +R L K+Y+ GG +G + L
Sbjct: 423 LFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTL 482
Query: 448 FTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTW 507
T E YN ++ W+V+ PM + R G+GV +YAVGG DG + L + E + P A W
Sbjct: 483 NTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQW 542
Query: 508 RTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSAL 567
+ TM PRS G+ V+ L+ VGG +G + +VEC+D T++W MS R +
Sbjct: 543 NFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGV 602
Query: 568 SCCVVPGL 575
GL
Sbjct: 603 GVTTWNGL 610
Score = 94.7 bits (234), Expect = 2e-19
Identities = 51/145 (35%), Positives = 77/145 (53%), Gaps = 7/145 (4%)
Query: 293 LFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVD- 351
L+A+GG G S ++E +D ++W + + R G G +Y IGG D+
Sbjct: 564 LYAVGGRDGSSCLKSVECFDPHTNKWT-LCAQMSKRRGGVGVTTWNGLLYAIGGHDAPAS 622
Query: 352 -----YFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERY 406
+ V+R+DP W VA M R V V +LG+ +YA+GG+DG LNT E Y
Sbjct: 623 NLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAY 682
Query: 407 EPETNQWTLIAPMHEQRSDASATTL 431
+P+TN+WT +AP+ R+ A T+
Sbjct: 683 DPQTNEWTQVAPLCLGRAGACVVTV 707
Score = 92.4 bits (228), Expect = 1e-18
Identities = 47/157 (29%), Positives = 75/157 (47%)
Query: 418 PMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIA 477
PM + + G ++ GG + + + E Y+ +N WT +A M RR GV
Sbjct: 406 PMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAV 465
Query: 478 YGEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNG 537
+ +Y VGG DG L + E Y+P TW +P M R G+ V++ ++ VGG +G
Sbjct: 466 LDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDG 525
Query: 538 FTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVVPG 574
++ VE +D + +W MS RS + V+ G
Sbjct: 526 WSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSG 562
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 328 bits (840), Expect = 1e-89
Identities = 178/543 (32%), Positives = 292/543 (53%), Gaps = 16/543 (2%)
Query: 37 KLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEY 96
+LCDV++ AH+ +L S S YF A+FT+ ++ + G+ P+ + +I+Y
Sbjct: 218 QLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQY 277
Query: 97 AYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPEL 156
AYT + + DN+E LL+ A + +V CC+FL +L NC+GI F D C +L
Sbjct: 278 AYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDL 337
Query: 157 RQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQ 216
+ A+ + + +F E+++ + EF+ L +E+ ++ D++N+ E+ + A+L W+ HD +
Sbjct: 338 HKVAHNYTMEHFMEVIR-NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLE 396
Query: 217 NRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMYDLNMNGPSN 276
R++ +S LL +RL L+ A F+ +++ N +D EC+ +I+ A+K ++
Sbjct: 397 QRRKDLSKLLAYIRLPLL-APQFLADMENNVLFRDDIECQKLIMEAMK----YHLLPERR 451
Query: 277 SDFTNPLTRPRLP-YAILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAA 335
+P T+PR LFA+GG +IE YD R + W V R G A
Sbjct: 452 PMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVA-NMNGRRLQFGVA 510
Query: 336 YLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFD 395
L +Y++GG D + N+V+ ++P KTW + PM + R + V VL +YA+GG D
Sbjct: 511 VLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHD 570
Query: 396 GYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNT 455
G+ LNT ER++P+ QW +A M RS L GK+Y GG +G+ CL + E ++
Sbjct: 571 GWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDP 630
Query: 456 ESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDG-ANRLRS-----AEAYSPVANTWRT 509
+N+WT+ A M RR G+GV + +YA+GG D A+ L S E Y P + W
Sbjct: 631 HTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTA 690
Query: 510 IPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSC 569
+ +M R G+ ++ D L+ VGG++G VE YD +T+EW + + R+
Sbjct: 691 VASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRA--GA 748
Query: 570 CVV 572
CVV
Sbjct: 749 CVV 751
Score = 131 bits (330), Expect = 2e-30
Identities = 67/188 (35%), Positives = 101/188 (53%)
Query: 388 IYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECL 447
++A+GG D + E+Y+ TN WT +A M+ +R L K+Y+ GG +G + L
Sbjct: 469 LFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTL 528
Query: 448 FTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTW 507
T E YN ++ W+V+ PM + R G+GV +YAVGG DG + L + E + P A W
Sbjct: 529 NTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQW 588
Query: 508 RTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSAL 567
+ TM PRS G+ V+ L+ VGG +G + +VEC+D T++W MS R +
Sbjct: 589 NFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGV 648
Query: 568 SCCVVPGL 575
GL
Sbjct: 649 GVTTWNGL 656
Score = 94.7 bits (234), Expect = 2e-19
Identities = 51/145 (35%), Positives = 77/145 (53%), Gaps = 7/145 (4%)
Query: 293 LFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVD- 351
L+A+GG G S ++E +D ++W + + R G G +Y IGG D+
Sbjct: 610 LYAVGGRDGSSCLKSVECFDPHTNKWT-LCAQMSKRRGGVGVTTWNGLLYAIGGHDAPAS 668
Query: 352 -----YFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERY 406
+ V+R+DP W VA M R V V +LG+ +YA+GG+DG LNT E Y
Sbjct: 669 NLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAY 728
Query: 407 EPETNQWTLIAPMHEQRSDASATTL 431
+P+TN+WT +AP+ R+ A T+
Sbjct: 729 DPQTNEWTQVAPLCLGRAGACVVTV 753
Score = 92.4 bits (228), Expect = 1e-18
Identities = 47/157 (29%), Positives = 75/157 (47%)
Query: 418 PMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIA 477
PM + + G ++ GG + + + E Y+ +N WT +A M RR GV
Sbjct: 452 PMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAV 511
Query: 478 YGEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNG 537
+ +Y VGG DG L + E Y+P TW +P M R G+ V++ ++ VGG +G
Sbjct: 512 LDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDG 571
Query: 538 FTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVVPG 574
++ VE +D + +W MS RS + V+ G
Sbjct: 572 WSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSG 608
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 325 bits (832), Expect = 1e-88
Identities = 185/579 (31%), Positives = 308/579 (53%), Gaps = 21/579 (3%)
Query: 2 EMESAAASTRFHQ-PHMERKMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSC 60
+M + + +FH H E+ + M N L+ E +LCDV++ AH+ +L +
Sbjct: 149 DMNATRSEEQFHVINHAEQTLRKME----NYLK-EKQLCDVLLIAGHLRIPAHRLVLSAV 203
Query: 61 SSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFN 120
S YF A+FT+ +++ + G+ P+ + +++YAYT + + D +E LLAAA
Sbjct: 204 SDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQ 263
Query: 121 IMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLE 180
+ ++ C FL +L NC+GI F D C EL A+ + + +F E++K + EFL
Sbjct: 264 LTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIK-NQEFLL 322
Query: 181 LSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFM 240
L E+ ++ D++NV E+ +F A+++W+ HD QNR+ + +LL +RL L+ + +
Sbjct: 323 LPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LL 381
Query: 241 NNVKMNDYVKDSEECKPVIINALKAMYDLNMNGPSNSDFTNPLTRPRLP-YAILFAIGGW 299
+++ + EC+ +++ A+K ++ S +P T+PR L+A+GG
Sbjct: 382 ADLETSSMFTGDLECQKLLMEAMK----YHLLPERRSMMQSPRTKPRKSTVGALYAVGGM 437
Query: 300 SGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRF 359
T IE YD R + W+++ R G A + +Y++GG D + N+V+ F
Sbjct: 438 DAMKGTTTIEKYDLRTNSWLHIGTMN-GRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECF 496
Query: 360 DPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPM 419
+PV K W + PM + R + V L +YA+GG DG+ LNT ER++PE QW +A M
Sbjct: 497 NPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASM 556
Query: 420 HEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYG 479
RS L K+Y GG +G+ CL + E ++ +N+W++ APM RR G+GV Y
Sbjct: 557 STPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYN 616
Query: 480 EHVYAVGGFDG-----ANRLRS-AEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVG 533
+Y VGG D +RL E Y P ++W T+ + PR + + D L+VVG
Sbjct: 617 GFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVG 676
Query: 534 GFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVV 572
G++G T VE YD + +EW + ++I R+ +C VV
Sbjct: 677 GYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAG-ACVVV 714
Score = 45.4 bits (106), Expect = 1e-04
Identities = 25/98 (25%), Positives = 44/98 (44%), Gaps = 7/98 (7%)
Query: 293 LFAIGGWSGGSP------TNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGG 346
L+ +GG + ++ +E YD + D W V PR L +Y++GG
Sbjct: 619 LYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVA-PLSVPRDAVAVCPLGDKLYVVGG 677
Query: 347 FDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVL 384
+D Y N+V+ +D + W + P++ R V V+
Sbjct: 678 YDGHTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVVV 715
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 322 bits (824), Expect = 8e-88
Identities = 180/564 (31%), Positives = 300/564 (53%), Gaps = 20/564 (3%)
Query: 2 EMESAAASTRFHQ-PHMERKMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSC 60
+M + + +FH H E+ + M N L+ E +LCDV++ AH+ +L +
Sbjct: 149 DMNATRSEEQFHVINHAEQTLRKME----NYLK-EKQLCDVLLIAGHLRIPAHRLVLSAV 203
Query: 61 SSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFN 120
S YF A+FT+ +++ + G+ P+ + +++YAYT + + D +E LLAAA
Sbjct: 204 SDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQ 263
Query: 121 IMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLE 180
+ ++ C FL +L NC+GI F D C EL A+ + + +F E++K + EFL
Sbjct: 264 LTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIK-NQEFLL 322
Query: 181 LSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFM 240
L E+ ++ D++NV E+ +F A+++W+ HD QNR+ + +LL +RL L+ + +
Sbjct: 323 LPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LL 381
Query: 241 NNVKMNDYVKDSEECKPVIINALKAMYDLNMNGPSNSDFTNPLTRPRLP-YAILFAIGGW 299
+++ + EC+ +++ A+K ++ S +P T+PR L+A+GG
Sbjct: 382 ADLETSSMFTGDLECQKLLMEAMK----YHLLPERRSMMQSPRTKPRKSTVGALYAVGGM 437
Query: 300 SGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRF 359
T IE YD R + W+++ R G A + +Y++GG D + N+V+ F
Sbjct: 438 DAMKGTTTIEKYDLRTNSWLHIGTMN-GRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECF 496
Query: 360 DPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPM 419
+PV K W + PM + R + V L +YA+GG DG+ LNT ER++PE QW +A M
Sbjct: 497 NPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASM 556
Query: 420 HEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYG 479
RS L K+Y GG +G+ CL + E ++ +N+W++ APM RR G+GV Y
Sbjct: 557 STPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYN 616
Query: 480 EHVYAVGGFDG-----ANRLRS-AEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVG 533
+Y VGG D +RL E Y P ++W T+ + PR + + D L+VVG
Sbjct: 617 GFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVG 676
Query: 534 GFNGFTTTFNVECYDEKTDEWYDA 557
G++G T VE YD + +EW ++
Sbjct: 677 GYDGHTYLNTVESYDAQRNEWKES 700
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 316 bits (810), Expect = 3e-86
Identities = 174/534 (32%), Positives = 287/534 (53%), Gaps = 16/534 (2%)
Query: 46 NGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPIT 105
N + S+ + +L S S YF A+FT+ ++ + G+ P+ + +I+YAYT + +
Sbjct: 166 NESDSSSCRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELK 225
Query: 106 PDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPELRQKAYMFIL 165
DN+E LL+ A + +V CC+FL +L NC+GI F D C +L + A+ + +
Sbjct: 226 EDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTM 285
Query: 166 HNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRKQHISIL 225
+F E+++ + EF+ L +E+ ++ D++N+ E+ + A+L W+ HD + R++ +S L
Sbjct: 286 EHFMEVIR-NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKL 344
Query: 226 LPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMYDLNMNGPSNSDFTNPLTR 285
L +RL L+ A F+ +++ N +D EC+ +I+ A+K ++ +P T+
Sbjct: 345 LAYIRLPLL-APQFLADMENNVLFRDDIECQKLIMEAMK----YHLLPERRPMLQSPRTK 399
Query: 286 PRLP-YAILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYII 344
PR LFA+GG +IE YD R + W V R G A L +Y++
Sbjct: 400 PRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVA-NMNGRRLQFGVAVLDDKLYVV 458
Query: 345 GGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAE 404
GG D + N+V+ ++P KTW + PM + R + V VL +YA+GG DG+ LNT E
Sbjct: 459 GGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVE 518
Query: 405 RYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIA 464
R++P+ QW +A M RS L GK+Y GG +G+ CL + E ++ +N+WT+ A
Sbjct: 519 RWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCA 578
Query: 465 PMRSRRSGIGVIAYGEHVYAVGGFDG-ANRLRS-----AEAYSPVANTWRTIPTMFNPRS 518
M RR G+GV + +YA+GG D A+ L S E Y P + W + +M R
Sbjct: 579 QMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRD 638
Query: 519 NFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVV 572
G+ ++ D L+ VGG++G VE YD +T+EW + + R+ CVV
Sbjct: 639 AVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRA--GACVV 690
Score = 131 bits (330), Expect = 2e-30
Identities = 67/188 (35%), Positives = 101/188 (53%)
Query: 388 IYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECL 447
++A+GG D + E+Y+ TN WT +A M+ +R L K+Y+ GG +G + L
Sbjct: 408 LFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTL 467
Query: 448 FTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTW 507
T E YN ++ W+V+ PM + R G+GV +YAVGG DG + L + E + P A W
Sbjct: 468 NTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQW 527
Query: 508 RTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSAL 567
+ TM PRS G+ V+ L+ VGG +G + +VEC+D T++W MS R +
Sbjct: 528 NFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGV 587
Query: 568 SCCVVPGL 575
GL
Sbjct: 588 GVTTWNGL 595
Score = 94.7 bits (234), Expect = 2e-19
Identities = 51/145 (35%), Positives = 77/145 (53%), Gaps = 7/145 (4%)
Query: 293 LFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVD- 351
L+A+GG G S ++E +D ++W + + R G G +Y IGG D+
Sbjct: 549 LYAVGGRDGSSCLKSVECFDPHTNKWT-LCAQMSKRRGGVGVTTWNGLLYAIGGHDAPAS 607
Query: 352 -----YFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERY 406
+ V+R+DP W VA M R V V +LG+ +YA+GG+DG LNT E Y
Sbjct: 608 NLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAY 667
Query: 407 EPETNQWTLIAPMHEQRSDASATTL 431
+P+TN+WT +AP+ R+ A T+
Sbjct: 668 DPQTNEWTQVAPLCLGRAGACVVTV 692
Score = 92.4 bits (228), Expect = 1e-18
Identities = 47/157 (29%), Positives = 75/157 (47%)
Query: 418 PMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIA 477
PM + + G ++ GG + + + E Y+ +N WT +A M RR GV
Sbjct: 391 PMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAV 450
Query: 478 YGEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNG 537
+ +Y VGG DG L + E Y+P TW +P M R G+ V++ ++ VGG +G
Sbjct: 451 LDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDG 510
Query: 538 FTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVVPG 574
++ VE +D + +W MS RS + V+ G
Sbjct: 511 WSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSG 547
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 316 bits (810), Expect = 3e-86
Identities = 178/550 (32%), Positives = 287/550 (52%), Gaps = 10/550 (1%)
Query: 28 IFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISP 87
+ E+R +GKLCDV +K+ +FSAH+ +L + YF A+FT+ ++ + G+ P
Sbjct: 27 VMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDP 86
Query: 88 DMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKF 147
++ +I +AY + I NV+ LL A + I CC FL+ L NC+G+ +F
Sbjct: 87 SALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQF 146
Query: 148 TDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAI 207
+ C L A FI +F E V +S EFL L + ++ +++ +DELNVK E+ VFEA
Sbjct: 147 AETMMCAVLYDAANSFIHQHFVE-VSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAA 205
Query: 208 LKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMY 267
L W+ +D + R ++ LL +RL L ++ + V+ +D V+ +C+ ++ A K +
Sbjct: 206 LAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEA-KDYH 264
Query: 268 DLNMNGPSNSDFTNPLTRPRLPYAI---LFAIGGW-SGGSPTNAIEAYDARADRWVNVTC 323
+ P F TRPR +I ++A+GG S G N +E +D A+ W
Sbjct: 265 LMPERRPHLPAFR---TRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCR- 320
Query: 324 EEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTV 383
+ R+ G A + G +Y IGG+D ++V+ ++P TW +V M+S+R + V
Sbjct: 321 PMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVV 380
Query: 384 LGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNG 443
L IY GG+DG L++ E Y PET++WT++ M RS A T G++Y+ GG +G
Sbjct: 381 LDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDG 440
Query: 444 NECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPV 503
+ + E YN + W A M ++R G + G ++ GG+DG+ L AE YS V
Sbjct: 441 LQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSV 500
Query: 504 ANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIY 563
A+ W I M RS + L+ VGG++G + +VE YD +TD W M+ +
Sbjct: 501 ADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPMACH 560
Query: 564 RSALSCCVVP 573
+ +P
Sbjct: 561 EGGVGVGCIP 570
Score = 102 bits (255), Expect = 8e-22
Identities = 54/147 (36%), Positives = 82/147 (55%), Gaps = 1/147 (0%)
Query: 429 TTLYGKVYICGGFNG-NECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGG 487
T++ G +Y GG N + L EV++ +N W PM + RS +GV +YA+GG
Sbjct: 284 TSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGG 343
Query: 488 FDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECY 547
+DG RL + EAY+P +TW + +M + RS G V+D ++V GG++G ++ +VE Y
Sbjct: 344 YDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETY 403
Query: 548 DEKTDEWYDAHDMSIYRSALSCCVVPG 574
+TD+W MS RSA V G
Sbjct: 404 SPETDKWTVVTSMSSNRSAAGVTVFEG 430
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 314 bits (805), Expect = 1e-85
Identities = 172/469 (36%), Positives = 259/469 (55%), Gaps = 9/469 (1%)
Query: 90 MKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTD 149
++++I+Y YT + +T +NV+ LL AA + + + CCEFL+S+L NC+GI F D
Sbjct: 19 LRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFAD 78
Query: 150 YYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILK 209
+ C +L KA + +F ++V +S EFL L + ++ +I D+L + E+ VFEA++
Sbjct: 79 MHACTDLLNKANTYAEQHFADVV-LSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIA 137
Query: 210 WISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMYDL 269
W++HD R++ ++ L+ VRL L+ EY + V+ VK+S CK +I A+K Y L
Sbjct: 138 WVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMK--YHL 195
Query: 270 NMNGPSNSDFTNPLTRPRLPYAI--LFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEES 327
+ + TR R P + L + G ++E YD + +RW V E S
Sbjct: 196 -LPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVA-ELPS 253
Query: 328 PRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNF 387
R G Y+ G V+ +GGF+ +V +DPVK W VA M RR + VL
Sbjct: 254 RRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGL 313
Query: 388 IYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNG--NE 445
+YA+GGFDG L++ E Y ++N+W +APM+ +RS + G +Y GG++G +
Sbjct: 314 LYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQ 373
Query: 446 CLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVAN 505
CL T E YN +N+WT IA M +RRSG GV +YAVGG DG +S E Y P N
Sbjct: 374 CLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTN 433
Query: 506 TWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEW 554
WR + M R N G+ V+ LL+VVGG +G +VE Y+ TD+W
Sbjct: 434 AWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKW 482
Score = 99.4 bits (246), Expect = 9e-21
Identities = 49/142 (34%), Positives = 84/142 (59%)
Query: 434 KVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANR 493
K+ + G + + + E Y+ + +W +A + SRR G++ V+AVGGF+G+ R
Sbjct: 219 KLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLR 278
Query: 494 LRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDE 553
+R+ ++Y PV + W ++ M + RS G V++ LL+ VGGF+G T +VE Y+ K++E
Sbjct: 279 VRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNE 338
Query: 554 WYDAHDMSIYRSALSCCVVPGL 575
W+ M+ RS++ VV GL
Sbjct: 339 WFHVAPMNTRRSSVGVGVVGGL 360
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 313 bits (802), Expect = 3e-85
Identities = 187/540 (34%), Positives = 285/540 (52%), Gaps = 15/540 (2%)
Query: 30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDM 89
N LR +LCD++++V + AHK +L S S YF+A+FT + E I
Sbjct: 26 NLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEVEFQCIDETA 85
Query: 90 MKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTD 149
++ I+EYAYT TV I+ D VE LL AA+ I +++ CC FL+S+L NCIGI +F +
Sbjct: 86 LQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGNCIGISRFAE 145
Query: 150 YYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILK 209
Y C +L A +I NFE + + + EF EL+ +L +I+ D LNV E+ VF A+
Sbjct: 146 TYGCRDLYLAATKYICQNFEAVCQ-TEEFFELTHADLDEIVSNDCLNVATEETVFYALES 204
Query: 210 WISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMYDL 269
WI +D Q R+++++ LL VRL L+ ++ + N ++D CK ++ ALK +
Sbjct: 205 WIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNEALKYHF-- 262
Query: 270 NMNGPSNSDFTNPLTRPRLPYAILFAIGGWSG-GSPTNAIEAYDARADRWVNVTCEEESP 328
M S T +TRPR +L A+GG SG + +++E Y + D W+ + P
Sbjct: 263 -MPEHRLSHQTVLMTRPRCAPKVLCAVGGKSGLFACLDSVEMYFPQNDSWIGL-APLNIP 320
Query: 329 RAYHGAAYLKGYVYIIGGFDS--------VDYFNSVKRFDPVKKTWHQVAPMHSRRCYVS 380
R G L VY+IGG + + NSV+ ++P TW + M+ R +
Sbjct: 321 RYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLG 380
Query: 381 VTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGG 440
V VL +YA+GG+DG L + E+Y P+ +W +APM RS +A L G +Y GG
Sbjct: 381 VVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGG 440
Query: 441 FNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAY 500
+ G + + E Y+ + W ++A M +R GV ++ VGG +G + L S E Y
Sbjct: 441 Y-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERY 499
Query: 501 SPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDM 560
P N W M PR+ G V+D+ L+VVGG +G + V+ YD +D W D+ M
Sbjct: 500 DPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGM 559
Score = 123 bits (308), Expect = 6e-28
Identities = 66/185 (35%), Positives = 101/185 (54%), Gaps = 2/185 (1%)
Query: 293 LFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDY 352
L+A+GG+ G S ++E Y + +W V + R+ AA L G +Y IGG+ +
Sbjct: 388 LYALGGYDGQSYLQSVEKYIPKIRKWQPVA-PMTTTRSCFAAAVLDGMIYAIGGYGPA-H 445
Query: 353 FNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQ 412
NSV+R+DP K +W VA M +R + V V+ FI+ +GG +G L++ ERY+P NQ
Sbjct: 446 MNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPHQNQ 505
Query: 413 WTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSG 472
WT+ PM E R+ A + +Y+ GG +G+ L T + Y+ S+ W A M R
Sbjct: 506 WTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGMIYCRCN 565
Query: 473 IGVIA 477
G+ A
Sbjct: 566 FGLTA 570
Score = 90.5 bits (223), Expect = 4e-18
Identities = 48/156 (30%), Positives = 82/156 (52%), Gaps = 8/156 (5%)
Query: 282 PLTRPRLPYA------ILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAA 335
P+T R +A +++AIGG+ G + N++E YD D W V + R + G
Sbjct: 418 PMTTTRSCFAAAVLDGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADK-RIHFGVG 475
Query: 336 YLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFD 395
+ G+++++GG + V + +S++R+DP + W PM R V V+ N++Y +GG
Sbjct: 476 VMLGFIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHS 535
Query: 396 GYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTL 431
G LNT ++Y+P ++ W A M R + T L
Sbjct: 536 GSSYLNTVQKYDPISDTWLDSAGMIYCRCNFGLTAL 571
Score = 70.9 bits (172), Expect = 3e-12
Identities = 40/140 (28%), Positives = 68/140 (48%), Gaps = 12/140 (8%)
Query: 446 CLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLR---------- 495
CL + E+Y +++ W +AP+ R G+ + VY +GG A +R
Sbjct: 297 CLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGI--ATNVRPGVTIRKHEN 354
Query: 496 SAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWY 555
S E ++P NTW ++ M RS G+ V+ L+ +GG++G + +VE Y K +W
Sbjct: 355 SVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQ 414
Query: 556 DAHDMSIYRSALSCCVVPGL 575
M+ RS + V+ G+
Sbjct: 415 PVAPMTTTRSCFAAAVLDGM 434
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 305 bits (781), Expect = 8e-83
Identities = 181/553 (32%), Positives = 288/553 (52%), Gaps = 19/553 (3%)
Query: 28 IFNELRLEGKLCDVVIKVN-----GFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNI 82
I NELRL +LCDV ++V +F AHK +L S S F+A+FT+G +V +I
Sbjct: 66 IMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSI 125
Query: 83 PGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCI 142
GI P +M+ +IE+AYT ++ + V ++ A + I +VR C +FL +L N I
Sbjct: 126 EGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAI 185
Query: 143 GICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDA 202
GI F + C EL Q+A +I +F E+ K EF LS +L +I +D+LNV+ E
Sbjct: 186 GIANFAEQIGCVELHQRAREYIYMHFGEVAK-QEEFFNLSHCQLVTLISRDDLNVRCESE 244
Query: 203 VFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINA 262
VF A + W+ +D + R+ ++ LL VR + + ++ + ++ CK ++
Sbjct: 245 VFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLV-- 302
Query: 263 LKAMYDLNMNGPSNSDFTNPLTRPRLPYAILFAIGGWSGGSPTNAIEAYDARADRWVNVT 322
K +L ++ P+ P P++ +++ GG+ S + +EAY+ W+ +
Sbjct: 303 -KIFEELTLHKPTQ---VMPCRAPKVG-RLIYTAGGYFRQS-LSYLEAYNPSDGTWLRLA 356
Query: 323 CEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNS----VKRFDPVKKTWHQVAPMHSRRCY 378
+ + PR+ + G +Y +GG ++ N+ + ++P+ W APM R
Sbjct: 357 -DLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNR 415
Query: 379 VSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYIC 438
+ V V+ IYA+GG G + N+ ERYEPE ++W L+APM +R L +Y
Sbjct: 416 IGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAV 475
Query: 439 GGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAE 498
GGF+G L +AE Y E N+W +I M + RSG GV +YA GG+DG ++L S E
Sbjct: 476 GGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVE 535
Query: 499 AYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAH 558
Y TW + M + RS GI V ++V+GG++G T +VECYD TD W +
Sbjct: 536 RYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVT 595
Query: 559 DMSIYRSALSCCV 571
M+ RS + V
Sbjct: 596 RMTSGRSGVGVAV 608
Score = 30.8 bits (68), Expect = 3.8
Identities = 16/51 (31%), Positives = 27/51 (52%), Gaps = 1/51 (1%)
Query: 525 VDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVVPGL 575
V L++ GG+ + ++ +E Y+ W D+ + RS L+ CVV GL
Sbjct: 324 VGRLIYTAGGYFRQSLSY-LEAYNPSDGTWLRLADLQVPRSGLAGCVVGGL 373
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 305 bits (781), Expect = 8e-83
Identities = 181/553 (32%), Positives = 288/553 (52%), Gaps = 19/553 (3%)
Query: 28 IFNELRLEGKLCDVVIKVN-----GFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNI 82
I NELRL +LCDV ++V +F AHK +L S S F+A+FT+G +V +I
Sbjct: 66 IMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSI 125
Query: 83 PGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCI 142
GI P +M+ +IE+AYT ++ + V ++ A + I +VR C +FL +L N I
Sbjct: 126 EGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAI 185
Query: 143 GICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDA 202
GI F + C EL Q+A +I +F E+ K EF LS +L +I +D+LNV+ E
Sbjct: 186 GIANFAEQIGCVELHQRAREYIYMHFGEVAK-QEEFFNLSHCQLVTLISRDDLNVRCESE 244
Query: 203 VFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINA 262
VF A + W+ +D + R+ ++ LL VR + + ++ + ++ CK ++
Sbjct: 245 VFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLV-- 302
Query: 263 LKAMYDLNMNGPSNSDFTNPLTRPRLPYAILFAIGGWSGGSPTNAIEAYDARADRWVNVT 322
K +L ++ P+ P P++ +++ GG+ S + +EAY+ W+ +
Sbjct: 303 -KIFEELTLHKPTQ---VMPCRAPKVG-RLIYTAGGYFRQS-LSYLEAYNPSDGTWLRLA 356
Query: 323 CEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNS----VKRFDPVKKTWHQVAPMHSRRCY 378
+ + PR+ + G +Y +GG ++ N+ + ++P+ W APM R
Sbjct: 357 -DLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNR 415
Query: 379 VSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYIC 438
+ V V+ IYA+GG G + N+ ERYEPE ++W L+APM +R L +Y
Sbjct: 416 IGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAV 475
Query: 439 GGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAE 498
GGF+G L +AE Y E N+W +I M + RSG GV +YA GG+DG ++L S E
Sbjct: 476 GGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVE 535
Query: 499 AYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAH 558
Y TW + M + RS GI V ++V+GG++G T +VECYD TD W +
Sbjct: 536 RYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVT 595
Query: 559 DMSIYRSALSCCV 571
M+ RS + V
Sbjct: 596 RMTSGRSGVGVAV 608
Score = 30.8 bits (68), Expect = 3.8
Identities = 16/51 (31%), Positives = 27/51 (52%), Gaps = 1/51 (1%)
Query: 525 VDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVVPGL 575
V L++ GG+ + ++ +E Y+ W D+ + RS L+ CVV GL
Sbjct: 324 VGRLIYTAGGYFRQSLSY-LEAYNPSDGTWLRLADLQVPRSGLAGCVVGGL 373
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 285 bits (728), Expect = 1e-76
Identities = 164/522 (31%), Positives = 265/522 (50%), Gaps = 7/522 (1%)
Query: 36 GKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIE 95
G+LCDV +KV S HK +L YFRA+F S ++ + I D ++ +++
Sbjct: 64 GELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVK 123
Query: 96 YAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPE 155
+ Y+ + +T DNV+ LL AA + + R CCE++K NC+ + F + + +
Sbjct: 124 FVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNRID 183
Query: 156 LRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDP 215
L A + +F E+V+ +F+ +S L ++ +LN++ E V+ A +KW+ +P
Sbjct: 184 LMDMADQYACDHFTEVVECE-DFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANP 242
Query: 216 QNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMYDLNMNGPS 275
Q+ + + L +VRL L+ ++ M V VK + +C+ ++ A Y L+++ +
Sbjct: 243 QHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARN--YHLHLSSRA 300
Query: 276 NSDFTNPL-TRPRLPYA-ILFAIGGWSG-GSPTNAIEAYDARADRWVNVTCEEESPRAYH 332
DF + T PR A +LF +GG G G P +IE Y + W E S R +
Sbjct: 301 VPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWF-FGPEMNSRRRHV 359
Query: 333 GAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMG 392
G ++G VY +GG D ++ S++ FDP+ W A M+++R +++ LG IYA+G
Sbjct: 360 GVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIG 419
Query: 393 GFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEV 452
G D N ERY+ E++QW+ +APM+ R + L VY GG +G L + E
Sbjct: 420 GLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVER 479
Query: 453 YNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPT 512
Y+ ++W + M RR+G GV +Y VGGFD + L S E Y P +N W +
Sbjct: 480 YDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAA 539
Query: 513 MFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEW 554
+ PR GI V +F VGG NG VE +D + W
Sbjct: 540 LTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRW 581
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 259 bits (662), Expect = 5e-69
Identities = 174/567 (30%), Positives = 283/567 (49%), Gaps = 28/567 (4%)
Query: 15 PHMERKMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNN 74
P K + + N++R CDV ++V F AH+ +L + S YF ALFT G
Sbjct: 13 PFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKE 72
Query: 75 TEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKS 134
+ K V I GI + ++++++ YT V I +NV++L+ AAD + +V CCEFLK
Sbjct: 73 SSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKG 132
Query: 135 ELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDE 194
++ NCIGI +F++ C +L + + +I +F E V EFL L+ +L I+ +E
Sbjct: 133 QIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLE-VHSGEEFLALTKDQLIKILRSEE 191
Query: 195 LNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEE 254
L+++ E VF A ++WI D R++H+ +L +R L+ + + ++ S+
Sbjct: 192 LSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIE-----GVSDF 246
Query: 255 CKPVIINALKAMYDLNMNGPSNSDFTNPL----TRPR-LPYAILFAIGG--------WSG 301
V + L Y P + F + L RPR L+A+GG WS
Sbjct: 247 NLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSD 306
Query: 302 GSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDP 361
+ +E +D + W V+ ++ R+ G L G VY IGG F+ + +DP
Sbjct: 307 SRALSCVERFDTFSQYWTTVSSLHQA-RSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDP 365
Query: 362 VKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHE 421
V K W VA M+ RC + V V IYA+GG+ G NT ER++P+ N+W ++ M
Sbjct: 366 VTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAV 425
Query: 422 QRSDASATTLYGKVYICGGFNGNEC-LFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGE 480
R + G +Y+ GG + L + EVY+ S +W+ + PM +RR+ +GV A +
Sbjct: 426 SRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALND 485
Query: 481 HVYAVGGF-DGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGG----- 534
+Y+VGG+ + + L + E YS W + +M PR+ + V+ LL+V GG
Sbjct: 486 CIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSH 545
Query: 535 -FNGFTTTFNVECYDEKTDEWYDAHDM 560
F T +VE Y+ +D W + +M
Sbjct: 546 DFLAPGTLDSVEVYNPHSDTWTEIGNM 572
Score = 84.0 bits (206), Expect = 4e-16
Identities = 42/140 (30%), Positives = 69/140 (49%)
Query: 439 GGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAE 498
G ++ + L E ++T S WT ++ + RSG+GV G VYA+GG + E
Sbjct: 302 GRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTE 361
Query: 499 AYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAH 558
Y PV W T+ +M +PR G+ V ++ +GG+ G +E +D ++W
Sbjct: 362 CYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVG 421
Query: 559 DMSIYRSALSCCVVPGLANV 578
+M++ R CC + GL V
Sbjct: 422 NMAVSRYYFGCCEMQGLIYV 441
>gi|223890235 intracisternal A particle-promoted polypeptide isoform
2 [Homo sapiens]
Length = 582
Score = 253 bits (646), Expect = 4e-67
Identities = 166/535 (31%), Positives = 270/535 (50%), Gaps = 22/535 (4%)
Query: 15 PHMERKMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNN 74
P K + + N++R CDV ++V F AH+ +L + S YF ALFT G
Sbjct: 13 PFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKE 72
Query: 75 TEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKS 134
+ K V I GI + ++++++ YT V I +NV++L+ AAD + +V CCEFLK
Sbjct: 73 SSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKG 132
Query: 135 ELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDE 194
++ NCIGI +F++ C +L + + +I +F E V EFL L+ +L I+ +E
Sbjct: 133 QIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLE-VHSGEEFLALTKDQLIKILRSEE 191
Query: 195 LNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEE 254
L+++ E VF A ++WI D R++H+ +L +R L+ + + ++ S+
Sbjct: 192 LSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIE-----GVSDF 246
Query: 255 CKPVIINALKAMYDLNMNGPSNSDFTNPL----TRPR-LPYAILFAIGG--------WSG 301
V + L Y P + F + L RPR L+A+GG WS
Sbjct: 247 NLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSD 306
Query: 302 GSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDP 361
+ +E +D + W V+ ++ R+ G L G VY IGG F+ + +DP
Sbjct: 307 SRALSCVERFDTFSQYWTTVSSLHQA-RSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDP 365
Query: 362 VKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHE 421
V K W VA M+ RC + V V IYA+GG+ G NT ER++P+ N+W ++ M
Sbjct: 366 VTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAV 425
Query: 422 QRSDASATTLYGKVYICGGFNGNEC-LFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGE 480
R + G +Y+ GG + L + EVY+ S +W+ + PM +RR+ +GV A +
Sbjct: 426 SRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALND 485
Query: 481 HVYAVGGF-DGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGG 534
+Y+VGG+ + + L + E YS W + +M PR+ + V+ LL+V GG
Sbjct: 486 CIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG 540
Score = 95.5 bits (236), Expect = 1e-19
Identities = 50/169 (29%), Positives = 84/169 (49%), Gaps = 3/169 (1%)
Query: 290 YAILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDS 349
Y ++A+GGW G N IE +D ++W V R Y G ++G +Y+IGG +
Sbjct: 389 YGAIYALGGWVGAEIGNTIERFDPDENKW-EVVGNMAVSRYYFGCCEMQGLIYVIGGISN 447
Query: 350 VDY-FNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGF-DGYVRLNTAERYE 407
S + +DP+ K W + PM +RR Y+ V L + IY++GG+ + L+T E+Y
Sbjct: 448 EGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYS 507
Query: 408 PETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTE 456
E +W +A M R+ + G +Y+ GG + + + + E
Sbjct: 508 FEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPDTHRYE 556
Score = 93.2 bits (230), Expect = 6e-19
Identities = 58/191 (30%), Positives = 89/191 (46%), Gaps = 11/191 (5%)
Query: 387 FIYAMGGFDGYV--------RLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYIC 438
++YA+GG+ L+ ER++ + WT ++ +H+ RS T L G VY
Sbjct: 289 YLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAI 348
Query: 439 GGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGV-IAYGEHVYAVGGFDGANRLRSA 497
GG + E Y+ + QWT +A M R G+GV + YG +YA+GG+ GA +
Sbjct: 349 GGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGA-IYALGGWVGAEIGNTI 407
Query: 498 EAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGF-NGFTTTFNVECYDEKTDEWYD 556
E + P N W + M R FG + L++V+GG N + E YD + W
Sbjct: 408 ERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSP 467
Query: 557 AHDMSIYRSAL 567
M R+ L
Sbjct: 468 LPPMGTRRAYL 478
Score = 84.0 bits (206), Expect = 4e-16
Identities = 42/140 (30%), Positives = 69/140 (49%)
Query: 439 GGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAE 498
G ++ + L E ++T S WT ++ + RSG+GV G VYA+GG + E
Sbjct: 302 GRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTE 361
Query: 499 AYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAH 558
Y PV W T+ +M +PR G+ V ++ +GG+ G +E +D ++W
Sbjct: 362 CYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVG 421
Query: 559 DMSIYRSALSCCVVPGLANV 578
+M++ R CC + GL V
Sbjct: 422 NMAVSRYYFGCCEMQGLIYV 441
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 252 bits (644), Expect = 6e-67
Identities = 164/534 (30%), Positives = 268/534 (50%), Gaps = 27/534 (5%)
Query: 27 EIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGIS 86
+IFNE R DV+I V G EF H+ +L +CSSYFRA+F + + + + I GI
Sbjct: 54 QIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGIL 113
Query: 87 PDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICK 146
+ M+ ++Y YT V IT +NV+ L + F I + C +FL+ +L NC+GI +
Sbjct: 114 AEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQR 173
Query: 147 FTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEA 206
F D + L K F L FE+ V EFLEL EL D I DEL + +E+ VFEA
Sbjct: 174 FADTHSLKTLFTKCKNFALQTFED-VSQHEEFLELDKDELIDYICSDELVIGKEEMVFEA 232
Query: 207 ILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAM 266
+++W+ R+ + LL VRL L+H YF+ V+++ +++S EC ++ A +
Sbjct: 233 VMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARR-- 290
Query: 267 YDLNMNGPSNSDFTNPLTRPRLPYA---ILFAIGGWS--GGSPTNAIEAYDARADRWVNV 321
Y + N + +P TRPR ++ +GG GG E YD W ++
Sbjct: 291 YHILGN-----EMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSL 345
Query: 322 TCEEESPRAYHGAAYLKGYVYIIGG-FDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVS 380
E ++ + L+ + + GG +S D V ++ W +VA ++ R
Sbjct: 346 AKLPEFTKSEYAVCALRNDILVSGGRINSRD----VWIYNSQLNIWIRVASLNKGRWRHK 401
Query: 381 VTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGG 440
+ VL +Y +GG+DG RL++ E Y+ +N+WT +AP+ E S + T+ GK+++ GG
Sbjct: 402 MAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGG 461
Query: 441 F-NGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEA 499
+ N C + Y+ E+N W + A + + I ++ +Y GG ++
Sbjct: 462 GPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGL-----TKAIYC 516
Query: 500 YSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGG--FNGFTTTFNVECYDEKT 551
Y PV + W + F+ + N G+ V + ++++GG NG T + CYD T
Sbjct: 517 YDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENG-EATDTILCYDPAT 569
Score = 74.3 bits (181), Expect = 3e-13
Identities = 51/179 (28%), Positives = 84/179 (46%), Gaps = 9/179 (5%)
Query: 378 YVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHE-QRSDASATTLYGKVY 436
Y V V+ +GGF+ L E Y+P T +W +A + E +S+ + L +
Sbjct: 311 YSEVIVVVGGCERVGGFN----LPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDIL 366
Query: 437 ICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRS 496
+ GG + ++ +YN++ N W +A + R + VY VGG+DG NRL S
Sbjct: 367 VSGGRINSRDVW---IYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSS 423
Query: 497 AEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGF-NGFTTTFNVECYDEKTDEW 554
E Y +N W + + S+ + LFV+GG + T + V+ YD +T+ W
Sbjct: 424 VECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSW 482
Score = 47.8 bits (112), Expect = 3e-05
Identities = 46/187 (24%), Positives = 80/187 (42%), Gaps = 27/187 (14%)
Query: 397 YVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYIC-------GGFNGNECLFT 449
Y L+ A RY N+ M R+ +T Y +V + GGFN L
Sbjct: 282 YQLLHEARRYHILGNE------MMSPRTRPRRSTGYSEVIVVVGGCERVGGFN----LPY 331
Query: 450 AEVYNTESNQWTVIAPMRS-RRSGIGVIAYGEHVYAVGGFDGANRLRSAEA--YSPVANT 506
E Y+ + +W +A + +S V A + GG R+ S + Y+ N
Sbjct: 332 TECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGG-----RINSRDVWIYNSQLNI 386
Query: 507 WRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDM--SIYR 564
W + ++ R + V+ ++VVGG++G +VECYD ++ W + + ++
Sbjct: 387 WIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSS 446
Query: 565 SALSCCV 571
A++ CV
Sbjct: 447 PAVTSCV 453
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 242 bits (617), Expect = 8e-64
Identities = 157/567 (27%), Positives = 274/567 (48%), Gaps = 23/567 (4%)
Query: 22 SAMACEIFNELRLEGKLCDVVIKVNGFE--FSAHKNILCSCSSYFRALFTSGWNNTEKKV 79
S++ + F++LRLEG LCDV + + F H+ ++ S S YF+A+FT G +
Sbjct: 75 SSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMC 134
Query: 80 YNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLD 139
+ G+S ++ II++ YT + + DN++ L AA I+ ++ C FL S + LD
Sbjct: 135 IKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLD 194
Query: 140 NCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQ 199
NC+ + + + Y E+ + F+L NF ++ + EFL+L L ++ + L
Sbjct: 195 NCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLS-TGEFLKLPFERLAFVLSSNSLKHCT 253
Query: 200 EDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVI 259
E +F+A +W+ + + R + L+ +R LM + +N V+ D+++ C ++
Sbjct: 254 ELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLL 312
Query: 260 INALKAMYDLNMNGPSNSDFTNPLTRPRLPYAILFAIGGWSGGS--PTNAIEAYDARADR 317
+ A M SD T R L +GG + + YD +A
Sbjct: 313 LEASNYQMMPYMQPVMQSD----RTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHE 368
Query: 318 WVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDY-----FNSVKRFDPVKKTWHQVAPM 372
W ++ ++PR HG A + ++Y++GG + D ++V RFDP W QVA +
Sbjct: 369 WKSLA-PMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASL 427
Query: 373 HSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLY 432
+ +R + ++ L ++YA+GG + L T E Y P TN+WT +A M E + T
Sbjct: 428 NEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYG 487
Query: 433 GKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGG--FDG 490
G +YI GG + ++ ++++W APM + R + GE +Y +GG F G
Sbjct: 488 GVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRG 547
Query: 491 A---NRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGF--NGFTTTFNVE 545
+ + S E YSP+ + W I M +S+ G+ V ++ ++VVGG+ N V+
Sbjct: 548 TSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQ 607
Query: 546 CYDEKTDEWYDAHDMSIYRSALSCCVV 572
YD DEW+ D+ + C +
Sbjct: 608 KYDPDKDEWHKVFDLPESLGGIRACTL 634
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 238 bits (607), Expect = 1e-62
Identities = 158/575 (27%), Positives = 268/575 (46%), Gaps = 28/575 (4%)
Query: 18 ERKMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEK 77
E K+ A + N +R + LCDV++ V + AH+ +L + S +F +FT+ ++
Sbjct: 23 EAKLLAGFMGVMNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKS 82
Query: 78 KVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELC 137
+ PD+++ ++E+AYT + + +NV+ LL AA+Q+ I + + C +FLK ++
Sbjct: 83 FEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVD 142
Query: 138 LDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNV 197
NC+GI + CPEL+ A FI +F E+ K EFL+L V + ++ +D L V
Sbjct: 143 ASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTD-EFLQLDVKRVTHLLNQDTLTV 201
Query: 198 KQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKP 257
+ ED V++A ++W+ +D NR+ + +L KVR L+ + V+ ++D+ EC
Sbjct: 202 RAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLK 261
Query: 258 VIINALKAMYDLNMNGPSNSDFTNPLTRPRL---PYAILFAIGGWSGGSPTNAIEAYDAR 314
++I+ ++ ++ P + + TRPR Y I GGS + ++ +
Sbjct: 262 MVISGMR----YHLLSPEDREELVDGTRPRRKKHDYRIAL-----FGGSQPQSCRYFNPK 312
Query: 315 ADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFD---PVKKTWHQVAP 371
W ++ C E R + VYI+GG +KR D VK +W+
Sbjct: 313 DYSWTDIRCPFEK-RRDAACVFWDNVVYILGG----SQLFPIKRMDCYNVVKDSWYSKLG 367
Query: 372 MHSRRCYVSVTVLGNFIYAMGGFD-GYVRLNTAERYEPETNQWTLIAPMHEQRSDASATT 430
+ R ++ IY GG + G L E Y+ T W M QR
Sbjct: 368 PPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVE 427
Query: 431 LYGKVYICGGFNGN----ECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVG 486
G +Y+CGG GN L + EVY+ + WT + PM R G++ + ++AVG
Sbjct: 428 ANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVG 487
Query: 487 GFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVEC 546
G +G L + E Y N W+ + M V +++V+ GF G ++
Sbjct: 488 GQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILE 547
Query: 547 YDEKTDEWYDAHDMSIY--RSALSCCVVPGLANVE 579
Y+ +TD+W + + S L C V AN E
Sbjct: 548 YNTETDKWVANSKVRAFPVTSCLICVVDTCGANEE 582
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 237 bits (604), Expect = 3e-62
Identities = 163/583 (27%), Positives = 281/583 (48%), Gaps = 28/583 (4%)
Query: 7 AASTRFHQPHMERKMSAMACEIFNELRLEGKLCDV-VIKVNGFE-FSAHKNILCSCSSYF 64
A +TRF + S++ + F++LR+EG LCDV ++ +G E F H+ ++ S S YF
Sbjct: 21 AGTTRFFTSNTH---SSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYF 77
Query: 65 RALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGI 124
+A+FT G + + G++ +K II++ YT + + DN++ L AA I+ +
Sbjct: 78 KAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPV 137
Query: 125 VRGCCEFLKSELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVT 184
+ C FL S + LDNC+ + + + Y E+ + FIL NF ++ + EFL+L
Sbjct: 138 LDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLS-TGEFLKLPFE 196
Query: 185 ELKDIIEKDELNVKQEDAVFEAILKWIS-HDPQNRKQHISILLPKVRLALMHAEYFMNNV 243
L ++ + L E +F+A +W+ DP R + + L+ +R LM + +N V
Sbjct: 197 RLAFVLSSNSLKHCTELELFKAACRWLRLEDP--RMDYAAKLMKNIRFPLMTPQDLINYV 254
Query: 244 KMNDYVKDSEECKPVIINALKAMYDLNMNGPSNSDFTNPLTRPRLPYAILFAIGGWSGGS 303
+ D+++ C +++ A M SD T R L +GG
Sbjct: 255 QTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSD----RTAIRSDSTHLVTLGGVLRQQ 310
Query: 304 --PTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDY-----FNSV 356
+ + YD RA W ++ ++PR HG A + ++Y++GG + D ++V
Sbjct: 311 LVVSKELRMYDERAQEWRSLA-PMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTV 369
Query: 357 KRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLI 416
RFDP W QVA ++ +R + ++ L +YA+GG L T E Y P N+W+ +
Sbjct: 370 FRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYV 429
Query: 417 APMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVI 476
A M E + T G +YI GG + ++ ++++W APM + R +
Sbjct: 430 AKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMC 489
Query: 477 AYGEHVYAVGG--FDGA---NRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFV 531
G+ +Y +GG F G + + S E YSP + W I M +S+ G+ V ++ ++V
Sbjct: 490 TVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYV 549
Query: 532 VGGF--NGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVV 572
VGG+ N V+ YD + DEW+ D+ + C +
Sbjct: 550 VGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTL 592
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 235 bits (600), Expect = 8e-62
Identities = 150/517 (29%), Positives = 256/517 (49%), Gaps = 30/517 (5%)
Query: 32 LRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMK 91
LR+E L DV++ V+ EFS H+ +L + S+YFRA+F + +K I G+ + M
Sbjct: 65 LRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAETMH 124
Query: 92 LIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTDYY 151
+++Y YT IT NV+++L AA+ F + +V C FL L +NC+GI + D +
Sbjct: 125 TLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLADTH 184
Query: 152 YCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWI 211
L+++ +I+ NF +++ S EFL+L V L I++ D+L V +E VFE ++ W+
Sbjct: 185 SLDSLKKQVQSYIIQNFVQILN-SEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMSWV 243
Query: 212 SHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMYDLNM 271
H P R + +L VRL L+ YF+ V+ + ++ E P++ A MY L
Sbjct: 244 RHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEA--RMYHL-- 299
Query: 272 NGPSNSDFTNPLTRPRL---PYAILFAIGGWSGG----------SPTNAIEAYDARADRW 318
S ++ + T+PR+ + IGG + P A+
Sbjct: 300 ---SGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLT 356
Query: 319 VNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCY 378
+ E LK VYI GG ++ + V +++ W Q+ ++ R
Sbjct: 357 EHELESENKKWVEFACVTLKNEVYISGGKETQ---HDVWKYNSSINKWIQIEYLNIGRWR 413
Query: 379 VSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYIC 438
+ VLG +Y +GGFDG R+N E Y+P N W+ AP+ S +AT+ K+Y+
Sbjct: 414 HKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVI 473
Query: 439 GGF-NGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSA 497
GG NG + Y+ +N+W++ A M I +++ + +Y VGG +R+
Sbjct: 474 GGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGG-----AMRAL 528
Query: 498 EAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGG 534
AYSP+ ++W + + + R++ GI ++ L++ GG
Sbjct: 529 YAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGG 565
Score = 52.0 bits (123), Expect = 2e-06
Identities = 41/202 (20%), Positives = 76/202 (37%), Gaps = 52/202 (25%)
Query: 293 LFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDY 352
++ IGG+ G N +E YD + W E +P H +++
Sbjct: 423 VYVIGGFDGLQRINNVETYDPFHNCW-----SEAAPLLVHVSSF---------------- 461
Query: 353 FNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQ 412
A H ++ Y V+G GG +G + + + Y+P TN+
Sbjct: 462 ----------------AATSHKKKLY----VIG------GGPNGKLATDKTQCYDPSTNK 495
Query: 413 WTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSG 472
W+L A M + +A + ++Y+ GG + Y+ + W ++ + R+
Sbjct: 496 WSLKAAMPVEAKCINAVSFRDRIYVVGG-----AMRALYAYSPLEDSWCLVTQLSHERAS 550
Query: 473 IGVIAYGEHVYAVGGFDGANRL 494
G+ +Y GG D N +
Sbjct: 551 CGIAPCNNRLYITGGRDEKNEV 572
Score = 35.0 bits (79), Expect = 0.20
Identities = 41/170 (24%), Positives = 66/170 (38%), Gaps = 40/170 (23%)
Query: 419 MHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAY 478
MHE +S+ I GG +E F AEV T + P+R R + +
Sbjct: 313 MHEFQSEV--------FMIIGGCTKDE-RFVAEV--------TCLDPLRRSRLEVAKLPL 355
Query: 479 GEH--------------------VYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRS 518
EH VY GG + + + Y+ N W I + R
Sbjct: 356 TEHELESENKKWVEFACVTLKNEVYISGGKETQHDVWK---YNSSINKWIQIEYLNIGRW 412
Query: 519 NFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALS 568
+ V+ ++V+GGF+G NVE YD + W +A + ++ S+ +
Sbjct: 413 RHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFA 462
>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
Length = 564
Score = 233 bits (595), Expect = 3e-61
Identities = 156/569 (27%), Positives = 265/569 (46%), Gaps = 30/569 (5%)
Query: 26 CEIF--NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIP 83
C F + + L+ LCDV++ V + AH+ +L + S +F +FT+ ++ +
Sbjct: 7 CRTFLTSHINLKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELK 66
Query: 84 GISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIG 143
PD+++ ++E+AYT + + +NV+ LL AA+Q+ I + + C +FLK ++ NC+G
Sbjct: 67 DAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLG 126
Query: 144 ICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAV 203
I + CPEL+ A FI +F E+ K EFL+L V + ++ +D L V+ ED V
Sbjct: 127 ISVLAECLDCPELKATADDFIHQHFTEVYKTD-EFLQLDVKRVTHLLNQDTLTVRAEDQV 185
Query: 204 FEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINAL 263
++A ++W+ +D NR+ + +L KVR L+ + V+ ++D+ EC ++I+ +
Sbjct: 186 YDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGM 245
Query: 264 KAMYDLNMNGPSNSDFTNPLTRPRL---PYAILFAIGGWSGGSPTNAIEAYDARADRWVN 320
+ ++ P + + TRPR Y I GGS + ++ + W +
Sbjct: 246 R----YHLLSPEDREELVDGTRPRRKKHDYRIAL-----FGGSQPQSCRYFNPKDYSWTD 296
Query: 321 VTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFD---PVKKTWHQVAPMHSRRC 377
+ C E R + VYI+GG +KR D VK +W+ + R
Sbjct: 297 IRCPFEK-RRDAACVFWDNVVYILGG----SQLFPIKRMDCYNVVKDSWYSKLGPPTPRD 351
Query: 378 YVSVTVLGNFIYAMGGFD-GYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVY 436
++ IY GG + G L E Y+ T W M QR G +Y
Sbjct: 352 SLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIY 411
Query: 437 ICGGFNGN----ECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGAN 492
+CGG GN L + EVY+ + WT + PM R G++ + ++AVGG +G
Sbjct: 412 VCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLG 471
Query: 493 RLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTD 552
L + E Y N W+ + M V +++V+ GF G ++ Y+ +TD
Sbjct: 472 GLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETD 531
Query: 553 EWYDAHDMSIY--RSALSCCVVPGLANVE 579
+W + + S L C V AN E
Sbjct: 532 KWVANSKVRAFPVTSCLICVVDTCGANEE 560
>gi|40255071 kelch-like 23 [Homo sapiens]
Length = 558
Score = 233 bits (595), Expect = 3e-61
Identities = 144/536 (26%), Positives = 260/536 (48%), Gaps = 30/536 (5%)
Query: 27 EIFNELRLEGKLCDVVIKV-NGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGI 85
+ F L+G D+ ++ +G F H+ +L +CS+YF+A+FT+ K + GI
Sbjct: 24 DAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKNKIKLSGI 83
Query: 86 SPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGIC 145
D+++ ++ YAYT + IT NV+ LL AAD + + + C FL L +DNCIG+
Sbjct: 84 HHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACERFLVRHLDIDNCIGMH 143
Query: 146 KFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFE 205
F +++ CPEL +++ + F+E V EFLE+S+ + I+ + L+V +E+A+ E
Sbjct: 144 SFAEFHVCPELEKESRRILCSKFKE-VWQQEEFLEISLEKFLFILSRKNLSVWKEEAIIE 202
Query: 206 AILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKA 265
++KW +HD +NR + + LL + + + + + + +I NAL
Sbjct: 203 PVIKWTAHDVENRIECLYNLLSYINIDIDPVYLKTALGLQRSCLLTENKIRSLIYNAL-- 260
Query: 266 MYDLNMNGPSNSDFTNPLTRPRLPYAILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEE 325
P + + + T A ++ IGG+ P + + +D + W+
Sbjct: 261 -------NPMHKEISQRST------ATMYIIGGYY-WHPLSEVHIWDPLTNVWIQGAEIP 306
Query: 326 ESPRAYHGAAYLKGYVYIIGGF--DSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTV 383
+ R +G L +Y+ GG+ D+++ ++V ++ W + PM + R Y
Sbjct: 307 DYTRESYGVTCLGPNIYVTGGYRTDNIEALDTVWIYNSESDEWTEGLPMLNARYYHCAVT 366
Query: 384 LGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNG 443
LG +YA+GG+ AE Y+P +W IA M + +A+A L+ +Y+ GG G
Sbjct: 367 LGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGVGNATACVLHDVIYVIGGHCG 426
Query: 444 --NECLF-TAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAY 500
C + + YN++ N+W++I G+ + + +Y VGG + E Y
Sbjct: 427 YRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFENKLYLVGG-----QTTITECY 481
Query: 501 SPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTF--NVECYDEKTDEW 554
P N WR I M R G +++ ++V GG++ T+ ++E YD ++W
Sbjct: 482 DPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKW 537
Score = 87.8 bits (216), Expect = 3e-17
Identities = 70/244 (28%), Positives = 106/244 (43%), Gaps = 20/244 (8%)
Query: 341 VYIIGGFDSVDYFNSVKR---FDPVKKTWHQVA--PMHSRRCYVSVTVLGNFIYAMGGF- 394
+YIIGG+ Y++ + +DP+ W Q A P ++R Y VT LG IY GG+
Sbjct: 275 MYIIGGY----YWHPLSEVHIWDPLTNVWIQGAEIPDYTRESY-GVTCLGPNIYVTGGYR 329
Query: 395 -DGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVY 453
D L+T Y E+++WT PM R A TL G VY GG+ AE Y
Sbjct: 330 TDNIEALDTVWIYNSESDEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFY 389
Query: 454 NTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGG---FDGANRLRSAEAYSPVANTWRTI 510
+ +W IA M + +Y +GG + G+ ++Y+ N W I
Sbjct: 390 DPLKEKWIPIANMIKGVGNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLI 449
Query: 511 PTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCC 570
+ +P ++ L++VGG T ECYD + +EW + M R
Sbjct: 450 TSSPHPEYGLCSVPFENKLYLVGGQTTIT-----ECYDPEQNEWREIAPMMERRMECGAV 504
Query: 571 VVPG 574
++ G
Sbjct: 505 IMNG 508
Score = 59.7 bits (143), Expect = 8e-09
Identities = 35/133 (26%), Positives = 70/133 (52%), Gaps = 17/133 (12%)
Query: 292 ILFAIGGWSG--GSPT-NAIEAYDARADRWVNVTCEEESPRAYHGAAYL--KGYVYIIGG 346
+++ IGG G GS T + +++Y++ + W +T SP +G + + +Y++GG
Sbjct: 417 VIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLIT---SSPHPEYGLCSVPFENKLYLVGG 473
Query: 347 FDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVR---LNTA 403
++ + +DP + W ++APM RR ++ IY GG+ Y + L +
Sbjct: 474 QTTI-----TECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYS-YSKGTYLQSI 527
Query: 404 ERYEPETNQWTLI 416
E+Y+P+ N+W ++
Sbjct: 528 EKYDPDLNKWEIV 540
Score = 47.4 bits (111), Expect = 4e-05
Identities = 37/163 (22%), Positives = 66/163 (40%), Gaps = 8/163 (4%)
Query: 413 WTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRS-RRS 471
+ + PMH++ S S T+Y I GG+ + L +++ +N W A + R
Sbjct: 257 YNALNPMHKEISQRSTATMY----IIGGYYWHP-LSEVHIWDPLTNVWIQGAEIPDYTRE 311
Query: 472 GIGVIAYGEHVYAVGGF--DGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLL 529
GV G ++Y GG+ D L + Y+ ++ W M N R + +
Sbjct: 312 SYGVTCLGPNIYVTGGYRTDNIEALDTVWIYNSESDEWTEGLPMLNARYYHCAVTLGGCV 371
Query: 530 FVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVV 572
+ +GG+ E YD ++W +M + CV+
Sbjct: 372 YALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGVGNATACVL 414
>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 875
Score = 221 bits (562), Expect = 2e-57
Identities = 152/541 (28%), Positives = 242/541 (44%), Gaps = 26/541 (4%)
Query: 30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFT-----SGWNNTEKKVYNIPG 84
N+ R D+ I V G EF H+N+L SCS YF+ L SG EK +
Sbjct: 320 NQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLSN 379
Query: 85 ISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGI 144
+ D+++L++E+ YT ++ I N + LL AA +F + C FL+ +L NC+G+
Sbjct: 380 LQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGV 439
Query: 145 CKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVF 204
+ C EL A F L F E V E L +S + + D LN K E+ V+
Sbjct: 440 LAMAEAMQCSELYHMAKAFALQIFPE-VAAQEEILSISKDDFIAYVSNDSLNTKAEELVY 498
Query: 205 EAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALK 264
E ++KWI DP R Q+ + LL VRL +H Y +N V + +K SE C+ ++ A +
Sbjct: 499 ETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKR 558
Query: 265 AMYDLNMNGPSNSDFTNPLTRPRLPYA---ILFAIGGWSGGSPTN----AIEAYDARADR 317
+M + + P TRPRL ++ +GG T A+ ++ + ++
Sbjct: 559 ----YHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNK 614
Query: 318 WVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRC 377
W + R + +Y+ GG +S V + + W+ V+ M RC
Sbjct: 615 WYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRC 674
Query: 378 YVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYI 437
+ V IY +GG ++ ERY+ TNQW +AP+ + A+AT GK+Y+
Sbjct: 675 RHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYV 734
Query: 438 CGGFN-GNECLFTAEVYNTESNQWTVI-APMRSRRSGIGVIAYGEHVYAVGGFDGANRLR 495
GG N + Y ++N W+ I +PM + V G V+ +GG R
Sbjct: 735 FGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNG-FVFILGG----AYAR 789
Query: 496 SAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGF--NGFTTTFNVECYDEKTDE 553
+ Y P + P M + R V+D ++ GG + N+E Y+ T+
Sbjct: 790 ATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNT 849
Query: 554 W 554
W
Sbjct: 850 W 850
Score = 32.3 bits (72), Expect = 1.3
Identities = 20/82 (24%), Positives = 34/82 (41%), Gaps = 1/82 (1%)
Query: 494 LRSAEAYSPVANTWRTIPTM-FNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTD 552
L + ++P N W + ++ F R F + D +++ GG T +V CY D
Sbjct: 602 LVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLD 661
Query: 553 EWYDAHDMSIYRSALSCCVVPG 574
W M++ R + V G
Sbjct: 662 NWNLVSRMTVPRCRHNSLVYDG 683
>gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain
containing 9 [Homo sapiens]
Length = 875
Score = 221 bits (562), Expect = 2e-57
Identities = 152/541 (28%), Positives = 242/541 (44%), Gaps = 26/541 (4%)
Query: 30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFT-----SGWNNTEKKVYNIPG 84
N+ R D+ I V G EF H+N+L SCS YF+ L SG EK +
Sbjct: 320 NQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLSN 379
Query: 85 ISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGI 144
+ D+++L++E+ YT ++ I N + LL AA +F + C FL+ +L NC+G+
Sbjct: 380 LQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGV 439
Query: 145 CKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVF 204
+ C EL A F L F E V E L +S + + D LN K E+ V+
Sbjct: 440 LAMAEAMQCSELYHMAKAFALQIFPE-VAAQEEILSISKDDFIAYVSNDSLNTKAEELVY 498
Query: 205 EAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALK 264
E ++KWI DP R Q+ + LL VRL +H Y +N V + +K SE C+ ++ A +
Sbjct: 499 ETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKR 558
Query: 265 AMYDLNMNGPSNSDFTNPLTRPRLPYA---ILFAIGGWSGGSPTN----AIEAYDARADR 317
+M + + P TRPRL ++ +GG T A+ ++ + ++
Sbjct: 559 ----YHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNK 614
Query: 318 WVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRC 377
W + R + +Y+ GG +S V + + W+ V+ M RC
Sbjct: 615 WYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRC 674
Query: 378 YVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYI 437
+ V IY +GG ++ ERY+ TNQW +AP+ + A+AT GK+Y+
Sbjct: 675 RHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYV 734
Query: 438 CGGFN-GNECLFTAEVYNTESNQWTVI-APMRSRRSGIGVIAYGEHVYAVGGFDGANRLR 495
GG N + Y ++N W+ I +PM + V G V+ +GG R
Sbjct: 735 FGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNG-FVFILGG----AYAR 789
Query: 496 SAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGF--NGFTTTFNVECYDEKTDE 553
+ Y P + P M + R V+D ++ GG + N+E Y+ T+
Sbjct: 790 ATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNT 849
Query: 554 W 554
W
Sbjct: 850 W 850
Score = 32.3 bits (72), Expect = 1.3
Identities = 20/82 (24%), Positives = 34/82 (41%), Gaps = 1/82 (1%)
Query: 494 LRSAEAYSPVANTWRTIPTM-FNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTD 552
L + ++P N W + ++ F R F + D +++ GG T +V CY D
Sbjct: 602 LVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLD 661
Query: 553 EWYDAHDMSIYRSALSCCVVPG 574
W M++ R + V G
Sbjct: 662 NWNLVSRMTVPRCRHNSLVYDG 683
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,496,831
Number of Sequences: 37866
Number of extensions: 969645
Number of successful extensions: 3344
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 177
Number of HSP's successfully gapped in prelim test: 26
Number of HSP's that attempted gapping in prelim test: 1908
Number of HSP's gapped (non-prelim): 468
length of query: 608
length of database: 18,247,518
effective HSP length: 108
effective length of query: 500
effective length of database: 14,157,990
effective search space: 7078995000
effective search space used: 7078995000
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.