Search of human proteins with 148536830

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|148536830 adenylate cyclase 3 [Homo sapiens]
         (1144 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|148536830 adenylate cyclase 3 [Homo sapiens]                      2276   0.0  
gi|4557257 adenylate cyclase 8 [Homo sapiens]                         677   0.0  
gi|34486092 adenylate cyclase 5 [Homo sapiens]                        663   0.0  
gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens]              624   e-178
gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens]              619   e-177
gi|115387102 adenylate cyclase 2 [Homo sapiens]                       587   e-167
gi|4557255 adenylate cyclase 7 [Homo sapiens]                         563   e-160
gi|31083193 adenylate cyclase 1 [Homo sapiens]                        556   e-158
gi|24497587 adenylate cyclase 4 [Homo sapiens]                        552   e-157
gi|50959205 adenylate cyclase 9 [Homo sapiens]                        380   e-105
gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens]    119   2e-26
gi|167830411 natriuretic peptide receptor 1 [Homo sapiens]            118   3e-26
gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Ho...   117   8e-26
gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho...   117   8e-26
gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho...   117   8e-26
gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Hom...   117   8e-26
gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho...   117   8e-26
gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Ho...   115   3e-25
gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens]       113   9e-25
gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens]        103   1e-21
gi|134152694 guanylate cyclase 2F [Homo sapiens]                      100   1e-20
gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Hom...    99   3e-20
gi|222080083 guanylate cyclase 2C [Homo sapiens]                       97   7e-20
gi|197313748 SET domain containing 2 [Homo sapiens]                    42   0.003
gi|76150625 nucleolar protein 1, 120kDa [Homo sapiens]                 36   0.24 
gi|76150623 nucleolar protein 1, 120kDa [Homo sapiens]                 36   0.24 
gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]               34   0.70 
gi|32483374 nucleolar protein 5A [Homo sapiens]                        33   1.2  
gi|38788260 bromodomain PHD finger transcription factor isoform ...    33   1.2  
gi|38788274 bromodomain PHD finger transcription factor isoform ...    33   1.2  

>gi|148536830 adenylate cyclase 3 [Homo sapiens]
          Length = 1144

 Score = 2276 bits (5898), Expect = 0.0
 Identities = 1144/1144 (100%), Positives = 1144/1144 (100%)

Query: 1    MPRNQGFSEPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPE 60
            MPRNQGFSEPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPE
Sbjct: 1    MPRNQGFSEPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPE 60

Query: 61   SLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLASLAVAGIGLVLDII 120
            SLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLASLAVAGIGLVLDII
Sbjct: 61   SLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLASLAVAGIGLVLDII 120

Query: 121  LFVLCKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFARAHAASDTVGWQVFFVFSFF 180
            LFVLCKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFARAHAASDTVGWQVFFVFSFF
Sbjct: 121  LFVLCKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFARAHAASDTVGWQVFFVFSFF 180

Query: 181  ITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREILANVFLYLCAIAVG 240
            ITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREILANVFLYLCAIAVG
Sbjct: 181  ITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREILANVFLYLCAIAVG 240

Query: 241  IMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDES 300
            IMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDES
Sbjct: 241  IMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDES 300

Query: 301  QKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQ 360
            QKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQ
Sbjct: 301  QKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQ 360

Query: 361  LRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTV 420
            LRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTV
Sbjct: 361  LRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTV 420

Query: 421  LGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCD 480
            LGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCD
Sbjct: 421  LGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCD 480

Query: 481  YLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSPALIETKEPNGSAHS 540
            YLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSPALIETKEPNGSAHS
Sbjct: 481  YLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSPALIETKEPNGSAHS 540

Query: 541  SGSTSEKPEEQDAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESA 600
            SGSTSEKPEEQDAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESA
Sbjct: 541  SGSTSEKPEEQDAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESA 600

Query: 601  QVVKKRNTFLLSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTN 660
            QVVKKRNTFLLSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTN
Sbjct: 601  QVVKKRNTFLLSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTN 660

Query: 661  YVTFMVGEILLLILTICSLAAIFPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMAN 720
            YVTFMVGEILLLILTICSLAAIFPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMAN
Sbjct: 661  YVTFMVGEILLLILTICSLAAIFPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMAN 720

Query: 721  VVDMLSCLQYYTGPSNATAGMETEGSCLENPKYYNYVAVLSLIATIMLVQVSHMVKLTLM 780
            VVDMLSCLQYYTGPSNATAGMETEGSCLENPKYYNYVAVLSLIATIMLVQVSHMVKLTLM
Sbjct: 721  VVDMLSCLQYYTGPSNATAGMETEGSCLENPKYYNYVAVLSLIATIMLVQVSHMVKLTLM 780

Query: 781  LLVAGAVATINLYAWRPVFDEYDHKRFREHDLPMVALEQMQGFNPGLNGTDRLPLVPSKY 840
            LLVAGAVATINLYAWRPVFDEYDHKRFREHDLPMVALEQMQGFNPGLNGTDRLPLVPSKY
Sbjct: 781  LLVAGAVATINLYAWRPVFDEYDHKRFREHDLPMVALEQMQGFNPGLNGTDRLPLVPSKY 840

Query: 841  SMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHV 900
            SMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHV
Sbjct: 841  SMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHV 900

Query: 901  ARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFD 960
            ARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFD
Sbjct: 901  ARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFD 960

Query: 961  SLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFA 1020
            SLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFA
Sbjct: 961  SLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFA 1020

Query: 1021 LAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVM 1080
            LAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVM
Sbjct: 1021 LAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVM 1080

Query: 1081 GNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDKLATFPNGPSVTLPHQV 1140
            GNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDKLATFPNGPSVTLPHQV
Sbjct: 1081 GNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDKLATFPNGPSVTLPHQV 1140

Query: 1141 VDNS 1144
            VDNS
Sbjct: 1141 VDNS 1144


>gi|4557257 adenylate cyclase 8 [Homo sapiens]
          Length = 1251

 Score =  677 bits (1746), Expect = 0.0
 Identities = 407/1090 (37%), Positives = 633/1090 (58%), Gaps = 93/1090 (8%)

Query: 53   MRLTFVPESLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSS--DKLASLAV 110
            +R +F    LE LYQ YF  QR ++ +V+ V   L    ++V+   + S+  D L  + +
Sbjct: 157  LRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILL 216

Query: 111  AGI-GLVLDIILFVLCKKGLLPDRVTRRVLPY---VLWLLITAQIFSYLGLNFARAHAAS 166
                G+ + I   V+ +K    D  +   L Y   V W+ +T QI +  GL +       
Sbjct: 217  GFFTGIEVVICALVVVRK----DTTSHTYLQYSGVVTWVAMTTQILA-AGLGYG---LLG 268

Query: 167  DTVGWQVFFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREI 226
            D +G+ +F +F+ +  LPL L+  ++  + + ++  ++L V + +        +  + ++
Sbjct: 269  DGIGYVLFTLFATYSMLPLPLTWAILAGLGTSLLQ-VILQVVIPRL------AVISINQV 321

Query: 227  LANVFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKH 286
            +A   L++C    GI   Y++DR  R+AFLE R+ +E ++ LE ++Q+QE L+LS+LP+ 
Sbjct: 322  VAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRF 381

Query: 287  VADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNE 346
            V  EM+ DM   E +  Q QF+ +Y++R+ENVSILFAD+ GFT LS+  SAQELV++LNE
Sbjct: 382  VVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNE 441

Query: 347  LFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTK 406
            LFARFD+LA ++H LRIKILGDCYYC+ GLP+ R+DHA C + MGL+M++ I YVR +TK
Sbjct: 442  LFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTK 501

Query: 407  TGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKG 466
              VDMR+G+H+G+VL GVLG ++WQ+DVWS DV +ANK+E+GGIPGR+HIS++T+DCL G
Sbjct: 502  HDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNG 561

Query: 467  EFDVEPGDGGSRCDYLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSP 526
            +++VE G G  R ++L +  IETYLI   +PE             +LP      S SSS 
Sbjct: 562  DYNVEEGHGKERNEFLRKHNIETYLI--KQPEDSLL---------SLPEDIVKESVSSS- 609

Query: 527  ALIETKEPNGSAHSSGSTS-EKPEEQDAQADNPSFPNPRRRLR-LQDLADRVVDASEDEH 584
                 +  +G+  + GS S E P +      N      R  +  L +   + +       
Sbjct: 610  ----DRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPE 665

Query: 585  ELNQLLNEALLERESAQVVKKRNTFLLSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLL 644
            E+N+ + E  ++  S   +++ +    S+ F D  +E +YS  +++   +   C+ +VLL
Sbjct: 666  EINKRI-EHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLL 724

Query: 645  -CTALVEILIDPWLMTNYVTFMVGEILLLILTICSLAAIFPRAFPKKLVAFSTWIDRTRW 703
              TA+  +L    +M   + F +  +L   L + + A  + +  P  L     WI+ T  
Sbjct: 725  FITAIQSLLPSSRVMPMTIQFSILIMLHSALVLITTAEDY-KCLPLILRKTCCWINETYL 783

Query: 704  ARNTWAMLAIFILVMANVVDMLSC-------LQYYTGPSNATAGMETEGSCLENPKYYNY 756
            ARN     +I I  +  ++++L C       L+  T  S+A             P+Y+ +
Sbjct: 784  ARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVF-----TDICSYPEYFVF 838

Query: 757  VAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPVFDEYDHKRFREHDLPMVA 816
              VL+++   + ++++ ++KL ++L++    A +    +  +F  YD+      D     
Sbjct: 839  TGVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGED----- 893

Query: 817  LEQMQGFNPGLNGTDRLPLVPSKYSMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHD 876
                        GT  + L        +++ + +L+ +Y  + +E  AR  FLW+++  +
Sbjct: 894  ----------FLGTKEVSL--------LLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKE 935

Query: 877  QKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFY 936
            +   + E+R  NE ++ N+LP HVARHFL   + +EELYSQ+YD +GVMFAS+P FADFY
Sbjct: 936  EINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFY 995

Query: 937  TEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGF 996
            ++  +NN G+ECLR LNEII+DFD LL   +F+ I KIKTIGSTYMA SG++P       
Sbjct: 996  SQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSP------- 1048

Query: 997  ASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGA 1056
                 E +   ++W HL  LADF+LA+ +++  IN  SFNNF LRIG++ G V+AGVIGA
Sbjct: 1049 -----EKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGA 1103

Query: 1057 RKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKG----KG 1112
            +KP YDIWG TVN+ASRM+STGV G IQV EET +IL++ GF F  RG I+VKG    +G
Sbjct: 1104 KKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEG 1163

Query: 1113 ELLTFFLKGR 1122
            ++ T+FL GR
Sbjct: 1164 KIKTYFLLGR 1173


>gi|34486092 adenylate cyclase 5 [Homo sapiens]
          Length = 1261

 Score =  663 bits (1710), Expect = 0.0
 Identities = 414/1156 (35%), Positives = 635/1156 (54%), Gaps = 92/1156 (7%)

Query: 3    RNQGFSEPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVP-ES 61
            + +   E E  A    E S    S  D G G      +     CL L +  R    P + 
Sbjct: 166  KGRAADELEAGAVEGGEGSGDGGSSADSGSGAGPGAVLSLGACCLALLQIFRSKKFPSDK 225

Query: 62   LENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLASLAVAGIGLVLDIIL 121
            LE LYQ YF R    +L +L+    L  C V++         +L  LAV    + + +I+
Sbjct: 226  LERLYQRYFFRLNQSSLTMLMAVLVLV-CLVMLAFHAARPPLQLPYLAVLAAAVGVILIM 284

Query: 122  FVLCKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFARAHAASDTVGWQVFFVFSFFI 181
             VLC +              ++ +++  Q+   +GL   +  +AS+ + W VFF+++ + 
Sbjct: 285  AVLCNRAAFHQDHMGLACYALIAVVLAVQV---VGLLLPQPRSASEGIWWTVFFIYTIYT 341

Query: 182  TLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREILANVFLYLCAIAVGI 241
             LP+ +   V+  V+   +H  +   T AQ Q        LL+++++NV ++ C   VG+
Sbjct: 342  LLPVRMRAAVLSGVLLSALHLAIALRTNAQDQF-------LLKQLVSNVLIFSCTNIVGV 394

Query: 242  MSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDESQ 301
             ++Y A+   R+AF E R+ ++ +++ + ++QQQE L+LS+LP+HVA EM  D+    ++
Sbjct: 395  CTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADIN---AK 451

Query: 302  KDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQL 361
            ++   F+ +Y+ +H+NVSILFADI GFT L+S C+AQELV  LNELFARFDKLAA+ H L
Sbjct: 452  QEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCL 511

Query: 362  RIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVL 421
            RIKILGDCYYC+ GLP+ R DHA C + MG+ M+EAIS VRE T   V+MRVG+H+G V 
Sbjct: 512  RIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVH 571

Query: 422  GGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDY 481
             GVLG ++WQ+DVWS DVT+AN MEAGG  GR+HI+++T++ L G+++VEPG GG R  Y
Sbjct: 572  CGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAY 631

Query: 482  LEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSPALIETKEPNGSAHSS 541
            L+E  IET+LI+    + K+          A  N    +S   +P     + P  + H  
Sbjct: 632  LKEHSIETFLILRCTQKRKEEKAM-----IAKMNRQRTNSIGHNPPHWGAERPFYN-HLG 685

Query: 542  GSTSEKPEEQDAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQ 601
            G+   K E +    ++P   N +     +D  D  +  + D   +++L +E +       
Sbjct: 686  GNQVSK-EMKRMGFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHV------- 737

Query: 602  VVKKRNTFLLSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTNY 661
                   FLL+  F +P++E +YS + + + GA  +C+ +V L    V+I I P  +   
Sbjct: 738  -----RKFLLT--FREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFML 790

Query: 662  VTFMVGEILLLILTICSLAAIFPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMANV 721
              ++   +LL ++   S+     + FP  L   S  I R++       +  I ++ +A  
Sbjct: 791  SFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAF 850

Query: 722  VDMLSC-----LQYYTGPSNATAGM----------------ETEGSC------LENPKYY 754
            V+M +C     L       N +A                  + +G C         P+Y+
Sbjct: 851  VNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYF 910

Query: 755  NYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPVFDEYDHKRFREHDLPM 814
             Y  +LSL+A  + +Q+S + KL LML +      I       +FD  D          +
Sbjct: 911  TYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNAD---------LL 961

Query: 815  VALEQMQGFNPGLNGTDRLPLVPSKYSMTV----MVFLMMLSFYYFSRHVEKLARTLFLW 870
            V    +  FN   NGT + P   +K ++ V    ++ + +L+ Y  ++ VE  AR  FLW
Sbjct: 962  VTANAIDFFN---NGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLW 1018

Query: 871  KIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGVMFASLP 930
            K++  ++KE + E++ +N  L+ N+LP+ VA HFL  ++R++ELY Q+ + + VMFAS+ 
Sbjct: 1019 KLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIA 1078

Query: 931  NFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPD 990
            NF++FY E   NN G+ECLR LNEII+DFD ++   +FR + KIKTIGSTYMAASG+   
Sbjct: 1079 NFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLND- 1137

Query: 991  VNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVL 1050
                  ++ +K  K+      H+  LADFA+ + D +  IN  SFNNF ++IG+N G V+
Sbjct: 1138 ------STYDKVGKT------HIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVV 1185

Query: 1051 AGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKG 1110
            AGVIGARKP YDIWGNTVNVASRM+STGV   IQV  +   +L    ++   RG + VKG
Sbjct: 1186 AGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKG 1245

Query: 1111 KGELLTFFLKGRDKLA 1126
            KGE++T+FL G   L+
Sbjct: 1246 KGEMMTYFLNGGPPLS 1261


>gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens]
          Length = 1168

 Score =  624 bits (1608), Expect = e-178
 Identities = 399/1105 (36%), Positives = 609/1105 (55%), Gaps = 101/1105 (9%)

Query: 52   FMRLTFVPESLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLASLAVA 111
            F    F    LE LYQ YF +    +L +L+    L    ++   A   +  + A +A+ 
Sbjct: 126  FQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAP-ARPQPAYVALL 184

Query: 112  GIGLVLDIILFVLCKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFARAHAASDTVGW 171
                 L + L V+C +          V   VL +L   Q+   L    A   + S  +  
Sbjct: 185  ACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALA---ADPRSPSAGLWC 241

Query: 172  QVFFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREILANVF 231
             VFFV+  +  LP+ +   V+  +    +H ++         Q       L +++ ANV 
Sbjct: 242  PVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAW-------QLNRGDAFLWKQLGANVL 294

Query: 232  LYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEM 291
            L+LC   +GI ++Y A+   R+AF E R  ++ +++L+ +++QQE L+LS+LP+HVA EM
Sbjct: 295  LFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEM 354

Query: 292  LKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARF 351
             +D+    ++K+   F+ +Y+ +H+NVSILFADI GFT L+S C+AQELV  LNELFARF
Sbjct: 355  KEDIN---TKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARF 411

Query: 352  DKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDM 411
            DKLAA+ H LRIKILGDCYYC+ GLP+ R DHA C + MG+ M+EAIS VRE T   V+M
Sbjct: 412  DKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNM 471

Query: 412  RVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVE 471
            RVG+H+G V  GVLG ++WQ+DVWS DVT+AN MEAGG  GR+HI+++T+  L G+++VE
Sbjct: 472  RVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVE 531

Query: 472  PGDGGSRCDYLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSPALIET 531
            PG GG R  YL+E+ IET+LI+         A+Q      A+      +  +S   L+  
Sbjct: 532  PGRGGERNAYLKEQHIETFLILG--------ASQKRKEEKAMLAKLQRTRANSMEGLMPR 583

Query: 532  KEPNGSAHSSGSTSEKPEEQDAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLN 591
              P+    +   T +    +    D+ S  N   +           DA   E E+++ L+
Sbjct: 584  WVPD---RAFSRTKDSKAFRQMGIDDSSKDNRGTQ-----------DALNPEDEVDEFLS 629

Query: 592  EALLERESAQVVKKR-NTFLLSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLLCTALVE 650
             A+  R   Q+ K     FLL+  F   ++E +YS + + + GA  +C+ +V      ++
Sbjct: 630  RAIDARSIDQLRKDHVRRFLLT--FQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQ 687

Query: 651  ILIDPWLMTNYVTFMVG---EILLLILTICSLAAIFP--RAFPKKLVAFSTWIDRTRWAR 705
            +LI P     + T M+G    I LL+L    + A++     FPK L   S  I R+R   
Sbjct: 688  LLIFP-----HSTLMLGIYASIFLLLLITVLICAVYSCGSLFPKALQRLSRSIVRSRAHS 742

Query: 706  NTWAMLAIFILVMANVVDMLSC----------LQYYTGPSNATA----------GMET-- 743
                + ++ ++  + + +M +C                P++ TA          G++   
Sbjct: 743  TAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLTPADITACHLQQLNYSLGLDAPL 802

Query: 744  -EGS--CLENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRP--V 798
             EG+      P+Y+    +LSL+A+ + + +S + KL  M+ V G +  + L    P  +
Sbjct: 803  CEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLA-MIFVLGLIYLVLLLLGPPATI 861

Query: 799  FDEYDHKRFREHDLPMVALEQMQGFNPGLNGTD--RLPLVPSKYSMTVMVFLMMLSFYYF 856
            FD YD          ++ +  +   N   +G D      V  KY   V++ +  L+ Y  
Sbjct: 862  FDNYD---------LLLGVHGLASSNETFDGLDCPAAGRVALKYMTPVILLVFALALYLH 912

Query: 857  SRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYS 916
            ++ VE  AR  FLWK++   +KE + E++ +N  L+ N+LP+ VA HFL  ++R++ELY 
Sbjct: 913  AQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYY 972

Query: 917  QTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKT 976
            Q+ + + VMFAS+ NF++FY E   NN G+ECLR LNEII+DFD ++   +FR + KIKT
Sbjct: 973  QSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKT 1032

Query: 977  IGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFN 1036
            IGSTYMAASG+          +++  D+  R    H+  LAD+A+ + + + +IN  SFN
Sbjct: 1033 IGSTYMAASGL----------NASTYDQVGR---SHITALADYAMRLMEQMKHINEHSFN 1079

Query: 1037 NFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREY 1096
            NF ++IG+N G V+AGVIGARKP YDIWGNTVNV+SRM+STGV   IQV  +   +L   
Sbjct: 1080 NFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAK 1139

Query: 1097 GFRFVRRGPIFVKGKGELLTFFLKG 1121
            G++   RG + VKGKGE+ T+FL G
Sbjct: 1140 GYQLECRGVVKVKGKGEMTTYFLNG 1164


>gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens]
          Length = 1115

 Score =  619 bits (1597), Expect = e-177
 Identities = 398/1080 (36%), Positives = 596/1080 (55%), Gaps = 104/1080 (9%)

Query: 52   FMRLTFVPESLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLASLAVA 111
            F    F    LE LYQ YF +    +L +L+    L    ++   A   +  + A +A+ 
Sbjct: 126  FQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAP-ARPQPAYVALL 184

Query: 112  GIGLVLDIILFVLCKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFARAHAASDTVGW 171
                 L + L V+C +          V   VL +L   Q+   L    A   + S  +  
Sbjct: 185  ACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALA---ADPRSPSAGLWC 241

Query: 172  QVFFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREILANVF 231
             VFFV+  +  LP+ +   V+  +    +H ++         Q       L +++ ANV 
Sbjct: 242  PVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAW-------QLNRGDAFLWKQLGANVL 294

Query: 232  LYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEM 291
            L+LC   +GI ++Y A+   R+AF E R  ++ +++L+ +++QQE L+LS+LP+HVA EM
Sbjct: 295  LFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEM 354

Query: 292  LKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARF 351
             +D+    ++K+   F+ +Y+ +H+NVSILFADI GFT L+S C+AQELV  LNELFARF
Sbjct: 355  KEDIN---TKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARF 411

Query: 352  DKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDM 411
            DKLAA+ H LRIKILGDCYYC+ GLP+ R DHA C + MG+ M+EAIS VRE T   V+M
Sbjct: 412  DKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNM 471

Query: 412  RVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVE 471
            RVG+H+G V  GVLG ++WQ+DVWS DVT+AN MEAGG  GR+HI+++T+  L G+++VE
Sbjct: 472  RVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVE 531

Query: 472  PGDGGSRCDYLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSPALIET 531
            PG GG R  YL+E+ IET+LI+         A+Q      A+      +  +S   L+  
Sbjct: 532  PGRGGERNAYLKEQHIETFLILG--------ASQKRKEEKAMLAKLQRTRANSMEGLMPR 583

Query: 532  KEPNGSAHSSGSTSEKPEEQDAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLN 591
              P+    +   T +    +    D+ S  N   +           DA   E E+++ L+
Sbjct: 584  WVPD---RAFSRTKDSKAFRQMGIDDSSKDNRGTQ-----------DALNPEDEVDEFLS 629

Query: 592  EALLERESAQVVKKR-NTFLLSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLLCTALVE 650
             A+  R   Q+ K     FLL+  F   ++E +YS + + + GA  +C+ +V      ++
Sbjct: 630  RAIDARSIDQLRKDHVRRFLLT--FQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQ 687

Query: 651  ILIDPWLMTNYVTFMVG---EILLLILTICSLAAIFP--RAFPKKLVAFSTWIDRTRWAR 705
            +LI P     + T M+G    I LL+L    + A++     FPK L   S  I R+R   
Sbjct: 688  LLIFP-----HSTLMLGIYASIFLLLLITVLICAVYSCGSLFPKALQRLSRSIVRSR--- 739

Query: 706  NTWAMLAIFILVMANVVDMLSCLQYYTGPSNATAGMETEGSCLENPKYYNYVAVLSLIAT 765
                         +  V + S L  +T   +A A M   G+ L           LSL+A+
Sbjct: 740  -----------AHSTAVGIFSVLLVFT---SAIANMYFIGNML-----------LSLLAS 774

Query: 766  IMLVQVSHMVKLTLMLLVAGAVATINLYAWRP--VFDEYDHKRFREHDLPMVALEQMQGF 823
             + + +S + KL  M+ V G +  + L    P  +FD YD          ++ +  +   
Sbjct: 775  SVFLHISSIGKLA-MIFVLGLIYLVLLLLGPPATIFDNYD---------LLLGVHGLASS 824

Query: 824  NPGLNGTD--RLPLVPSKYSMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERV 881
            N   +G D      V  KY   V++ +  L+ Y  ++ VE  AR  FLWK++   +KE +
Sbjct: 825  NETFDGLDCPAAGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEM 884

Query: 882  YEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESI 941
             E++ +N  L+ N+LP+ VA HFL  ++R++ELY Q+ + + VMFAS+ NF++FY E   
Sbjct: 885  EELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEA 944

Query: 942  NNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFASSNK 1001
            NN G+ECLR LNEII+DFD ++   +FR + KIKTIGSTYMAASG+          +++ 
Sbjct: 945  NNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGL----------NAST 994

Query: 1002 EDKSERERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHY 1061
             D+  R    H+  LAD+A+ + + + +IN  SFNNF ++IG+N G V+AGVIGARKP Y
Sbjct: 995  YDQVGR---SHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQY 1051

Query: 1062 DIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKG 1121
            DIWGNTVNV+SRM+STGV   IQV  +   +L   G++   RG + VKGKGE+ T+FL G
Sbjct: 1052 DIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNG 1111


>gi|115387102 adenylate cyclase 2 [Homo sapiens]
          Length = 1091

 Score =  587 bits (1514), Expect = e-167
 Identities = 379/1102 (34%), Positives = 584/1102 (52%), Gaps = 91/1102 (8%)

Query: 58   VPESLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFS-----SDKLASLAVAG 112
            +P S + LY++Y+   +   L+V ++   +  C  + + AV F+      D +A L    
Sbjct: 26   LPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSC--LALLAVFFALGLEVEDHVAFLITVP 83

Query: 113  IGLVLDIILFVL-CKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFARAHAASDTVGW 171
              L +   +F+L C + +    +  R+   V+W+ + A    YL + F    +  D V +
Sbjct: 84   TALAIFFAIFILVCIESVFKKLL--RLFSLVIWICLVAM--GYLFMCFGGTVSPWDQVSF 139

Query: 172  QVFFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREILANVF 231
             +F +F  +  LP ++   +I SV++   HT+VL V ++     +     L+ +ILANV 
Sbjct: 140  FLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSATPGGK---EHLVWQILANVI 196

Query: 232  LYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEM 291
            +++C    G    ++ +   ++ + +    ++ ++ LE + +QQE L+LS+LP H+A EM
Sbjct: 197  IFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEM 256

Query: 292  LKDM------KKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLN 345
              ++       K    ++   F+ +Y+ RH NVSIL+ADIVGFT+L+S CS  ELV +LN
Sbjct: 257  KAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLN 316

Query: 346  ELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKT 405
            ELF +FD++A +   +RIKILGDCYYC+ GLP    +HA   + MGL M EAI  VR+ T
Sbjct: 317  ELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDAT 376

Query: 406  KTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLK 465
               ++MRVGVH+G VL GV+G ++WQYDVWS DVT+AN MEAGG+PGRVHIS  T++ L 
Sbjct: 377  GVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLN 436

Query: 466  GEFDVEPGDGGSRCDYLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASSKSSS 525
            G + VE GDG  R  YL++  ++TY +I   P+ ++ + Q+        +GA   +    
Sbjct: 437  GAYKVEEGDGDIRDPYLKQHLVKTYFVI--NPKGERRSPQHLFRPRHTLDGAKMRASVRM 494

Query: 526  PALIET---KEPNGSAHSSGS-TSE--KPEEQDAQADNPSFPNPRRRLRLQDLADRVVDA 579
               +E+    +P    H   S T+E  K    D      +F N  R LR +    R    
Sbjct: 495  TRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQN--RTLRTKSQKKRF--- 549

Query: 580  SEDEHELNQLLNEALLE-RESAQVVKKRNTFLLSMRFMDPEMETRYSVEKEKQSGAAFSC 638
               E ELN+ + +A+       Q +K  +   +S+ F +  +E  Y            +C
Sbjct: 550  ---EEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTC 606

Query: 639  SCVVLLCTALVEILIDPWLMTNYVTFMVGEILL-LILTICSLAAIFPRAFPKKLVAFSTW 697
            +C++  C  +V+IL+ P      ++F    +LL  IL +C    +   +  KK      W
Sbjct: 607  ACLIFFCIFIVQILVLPKTSVLGISFGAAFLLLAFILFVCFAGQLLQCS--KKASPLLMW 664

Query: 698  IDRTRW--ARNTWAMLAIFILVMANVVDMLSCLQYYTGPSNATA-----GMETEGSCLEN 750
            + ++    A   W  +++ I+  A ++ M     ++   S  T         T  S   N
Sbjct: 665  LLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFSASNN 724

Query: 751  P------------KYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPV 798
                          Y+ Y  +L LI+  + ++V++ +K+ +M++      TI L+    V
Sbjct: 725  QVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHV 784

Query: 799  FDEYDHKRFREHDLPMVALEQMQGFNPGLNGTDRLPLVPSKYSMTVMVFLMMLSFYYFSR 858
              +Y    F                 PG+           K   +V + +  ++     R
Sbjct: 785  LGDYSQVLFE---------------RPGI-------WKDLKTMGSVSLSIFFITLLVLGR 822

Query: 859  HVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQT 918
              E   R  FLWK +   ++E +  M   N  L+ N+LP HVA HFL    ++EELY Q+
Sbjct: 823  QNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQS 882

Query: 919  YDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIG 978
            YD + VMFAS+P+F +FYTE  +N  G+ECLR LNEII+DFD LL  PKF  + KIKTIG
Sbjct: 883  YDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIG 942

Query: 979  STYMAASGVTPDVNTNGFASSNKEDKSERER-WQHLADLADFALAMKDTLTNINNQSFNN 1037
            STYMAA+G++        A  ++E   E ER + H+  + +FA A+   L  IN  SFN+
Sbjct: 943  STYMAATGLS--------AVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFND 994

Query: 1038 FMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYG 1097
            F LR+G+N G V+AGVIGA+KP YDIWGNTVNVASRM+STGV+  IQV EET ++L+  G
Sbjct: 995  FKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLG 1054

Query: 1098 FRFVRRGPIFVKGKGELLTFFL 1119
            +    RG I VKGKG+L T+F+
Sbjct: 1055 YTCTCRGIINVKGKGDLKTYFV 1076


>gi|4557255 adenylate cyclase 7 [Homo sapiens]
          Length = 1080

 Score =  563 bits (1450), Expect = e-160
 Identities = 381/1083 (35%), Positives = 569/1083 (52%), Gaps = 64/1083 (5%)

Query: 65   LYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLASLAVAGIGLV-------L 117
            LY+ Y    +H  LL+ ++  A   C  +++ A     D     A+ G+  +       L
Sbjct: 21   LYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFS-QGDPSRHQAILGMAFLVLAVFAAL 79

Query: 118  DIILFVLCKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFARAHAASDTVGWQVFFVF 177
             ++++V C   LL  R   R L  + W  + A  +  +   + +A  A + V + +F VF
Sbjct: 80   SVLMYVEC---LL--RRWLRALALLTWACLVALGYVLVFDAWTKAACAWEQVPFFLFIVF 134

Query: 178  SFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELK-GMQLLREILANVFLYLCA 236
              +  LP S+   V +  VS   H LVLG  +       ++ G+QLL    AN  ++LC 
Sbjct: 135  VVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGLQLL----ANAVIFLCG 190

Query: 237  IAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEM----L 292
               G    +      R  F    + ++++  L  + +QQENL+LS+LP H++  M    +
Sbjct: 191  NLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAHISMGMKLAII 250

Query: 293  KDMKK--DESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFAR 350
            + +K+  D        F+++Y+ RH+NVSIL+ADIVGFTQL+S CS +ELV +LNELF +
Sbjct: 251  ERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKELVVVLNELFGK 310

Query: 351  FDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVD 410
            FD++A     +RIKILGDCYYC+ GLP     HA   + MGL M +AI  VRE T   ++
Sbjct: 311  FDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQVREATGVDIN 370

Query: 411  MRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDV 470
            MRVG+H+G VL GV+G ++WQYDVWS DV++AN+MEA G+PGRVHI+++T+  L   ++V
Sbjct: 371  MRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLKHLDKAYEV 430

Query: 471  EPGDGGSRCDYLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSPALIE 530
            E G G  R  YL+E  I TYL+I  + +     +Q+       P G  A    +S  +  
Sbjct: 431  EDGHGQQRDPYLKEMNIRTYLVIDPRSQQPPPPSQH----LPRPKGDAALKMRASVRMTR 486

Query: 531  TKEPNGSAHSSGSTSEKPEEQDAQADNPSFPNPR----RRLRLQDLADRVVDASEDEHEL 586
              E  G+A      + +      +   P+   P+    R  R  D +      SED+   
Sbjct: 487  YLESWGAARPFAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMSPKGRSEDDSYD 546

Query: 587  NQLLNEAL-LERESAQVVKKRNTFLLSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLLC 645
            +++L+    L        K  + +     F++   E  Y +    ++   F+C+ ++ +C
Sbjct: 547  DEMLSAIEGLSSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDFACASLIFVC 606

Query: 646  TALVEILIDPWLMTNYVTF-MVGEILLLILTICSLAAIFPRAFPKK--LVAFSTWIDRTR 702
              LV +L+ P      V+F +V  +L L+L +C  A  F R  P +  L   S  ++   
Sbjct: 607  ILLVHVLLMPRTAALGVSFGLVACVLGLVLGLC-FATKFSRCCPARGTLCTISERVETQP 665

Query: 703  WARNTWAMLAIFILVMANVVDM-LSCLQYYTGPSNATAGM-----ETEGSCLENPKYYNY 756
              R T A+L I  L+   ++++ L   Q    P     G+     +T   C   P YY  
Sbjct: 666  LLRLTLAVLTIGSLLTVAIINLPLMPFQVPELPVGNETGLLAASSKTRALCEPLP-YYTC 724

Query: 757  VAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPVFDEYDHKRFREHDLPMVA 816
              VL  IA  + +++S  ++  ++LL    VA + L+   P +         + D     
Sbjct: 725  SCVLGFIACSVFLRMS--LEPKVVLLTVALVAYLVLFNLSPCW---------QWDCCGQG 773

Query: 817  LEQMQGFNPGLNGTDRLPLVPSKYSMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHD 876
            L  +   N   +GT        K      + L  ++    SR ++   R   LWK +   
Sbjct: 774  LGNLTKPNGTTSGTPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCRLDCLWKKKFKK 833

Query: 877  QKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFY 936
            + E    M   N  L+ N+LP HVA HF+G  K +E+ Y Q+YD + VMFAS+P+F  FY
Sbjct: 834  EHEEFETMENVNRLLLENVLPAHVAAHFIGD-KLNEDWYHQSYDCVCVMFASVPDFKVFY 892

Query: 937  TEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGF 996
            TE  +N  G+ECLR LNEII+DFD LL  PKF  + KIKTIGSTYMAA+G++        
Sbjct: 893  TECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLS-------V 945

Query: 997  ASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGA 1056
            AS ++  + ER+   H+  + +F++A+   L  IN  SFN+F LR+G+N G V+AGVIGA
Sbjct: 946  ASGHENQELERQH-AHIGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGA 1004

Query: 1057 RKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLT 1116
            RKP YDIWGNTVNVASRMESTG +G IQV EET  IL+  G+    RG I VKGKGEL T
Sbjct: 1005 RKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRT 1064

Query: 1117 FFL 1119
            +F+
Sbjct: 1065 YFV 1067


>gi|31083193 adenylate cyclase 1 [Homo sapiens]
          Length = 1119

 Score =  556 bits (1432), Expect = e-158
 Identities = 353/980 (36%), Positives = 533/980 (54%), Gaps = 114/980 (11%)

Query: 171  WQVFFV-FSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREILAN 229
            WQ+  V F  +  LP+     +   +V    H LV    V  ++       +L R + AN
Sbjct: 164  WQLLLVTFVSYALLPVRSLLAIGFGLVVAASHLLVTATLVPAKRP------RLWRTLGAN 217

Query: 230  VFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVAD 289
              L++     G+    + +R  RKAFL+AR  +E ++ LE+++++QE L++S+LP++VA 
Sbjct: 218  ALLFVGVNMYGVFVRILTERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAM 277

Query: 290  EMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFA 349
            EM +D  K      ++ F+ +Y+ RH+NVSILFADIVGFT L+S C+AQELVKLLNELF 
Sbjct: 278  EMKEDFLKPP----ERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFG 333

Query: 350  RFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGV 409
            +FD+LA + H  RIKILGDCYYC+ GL   + DHA C + MGL M++ I+ V E T+  +
Sbjct: 334  KFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDL 393

Query: 410  DMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFD 469
            +MRVG+HTG VL GVLG ++WQYDVWS DVT+AN MEA G+PG+VHI+++T+ CL G+++
Sbjct: 394  NMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYE 453

Query: 470  VEPGDGGSRCDYLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSPALI 529
            VEPG G  R  +L+   IET+ I+ S     +     GL  S +        K+    L+
Sbjct: 454  VEPGYGHERNSFLKTHNIETFFIVPS----HRRKIFPGLILSDIKPAKRMKFKTVCYLLV 509

Query: 530  E------------------TKEPNGSAHSSGSTSEKPEEQDAQADNPSFPNPRRRLRLQD 571
            +                  T E +    +  + SEK   + + + N  +  P    R+  
Sbjct: 510  QLMHCRKMFKAEIPFSNVMTCEDDDKRRALRTASEKLRNRSSFSTNVVYTTP--GTRVNR 567

Query: 572  LADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLLSMRFMDPEMETRYSVEKEKQ 631
               R+++A + E E+  L                 N F  ++++   E E +Y   +++ 
Sbjct: 568  YISRLLEARQTELEMADL-----------------NFF--TLKYKHVEREQKYHQLQDEY 608

Query: 632  SGAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILTICSLAAIFPRAFPKKL 691
              +A   + ++     LV +LI P          V  +LLL+  IC L A        ++
Sbjct: 609  FTSAVVLTLILAALFGLVYLLIFPQ--------SVVVLLLLVFCICFLVACVLYLHITRV 660

Query: 692  VAFSTWIDRTRWARNTWAMLAIFILVMANVVD---MLSCL--QYYTGPSNATAGMETEGS 746
              F   +           +L IFI+V+   V    ++ CL   + + P+++   + + G 
Sbjct: 661  QCFPGCL-----TIQIRTVLCIFIVVLIYSVAQGCVVGCLPWAWSSKPNSSLVVLSSGGQ 715

Query: 747  CLENP----KYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPVFDEY 802
                P    +  ++  +  L+ T+ L     +  L  M+L++G   +             
Sbjct: 716  RTALPTLPCESTHHALLCCLVGTLPLAIFFRVSSLPKMILLSGLTTS------------- 762

Query: 803  DHKRFREHDLPMVALEQMQGFNPGLNGTDRLPLVPSKYSMTVMVFLMMLSFYYFSRHVEK 862
                        + + ++ G+     G     +    Y   V + L   +    +R V+ 
Sbjct: 763  -----------YILVLELSGYTRTGGGA----VSGRSYEPIVAILLFSCALALHARQVDI 807

Query: 863  LARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQTYDEI 922
              R  +LW  +  +++E + +++  N  ++ N+LP HVA+HFL S  R+ +LY Q+Y ++
Sbjct: 808  RLRLDYLWAAQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQV 867

Query: 923  GVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYM 982
            GVMFAS+PNF DFY E   NN G+ECLR LNEII+DFD L++   ++ I KIKTIGSTYM
Sbjct: 868  GVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYM 927

Query: 983  AASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFNNFMLRI 1042
            AA G+ P   T          K+++    HL+ LADFA+ M D L  IN QS+N+F+LR+
Sbjct: 928  AAVGLAPTSGT----------KAKKSISSHLSTLADFAIEMFDVLDEINYQSYNDFVLRV 977

Query: 1043 GMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVR 1102
            G+N G V+AGVIGAR+P YDIWGNTVNVASRM+STGV G IQV EE   +LR   + FV 
Sbjct: 978  GINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCPYHFVC 1037

Query: 1103 RGPIFVKGKGELLTFFLKGR 1122
            RG + VKGKGE+LT+FL+GR
Sbjct: 1038 RGKVSVKGKGEMLTYFLEGR 1057



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 73/279 (26%), Positives = 125/279 (44%), Gaps = 38/279 (13%)

Query: 861  EKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARH----FLGSKKRD-EELY 915
            E+  R  FL      + + R+ +     E L+ ++LP +VA      FL   +R   ++Y
Sbjct: 236  ERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIY 295

Query: 916  SQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIK 975
             Q +D + ++FA +  F    ++ +      E ++ LNE+   FD L      R   +IK
Sbjct: 296  IQRHDNVSILFADIVGFTGLASQCTAQ----ELVKLLNELFGKFDELATENHCR---RIK 348

Query: 976  TIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSF 1035
             +G  Y   SG+T                  + +  H     +  L M DT+T++   + 
Sbjct: 349  ILGDCYYCVSGLT------------------QPKTDHAHCCVEMGLDMIDTITSVAEATE 390

Query: 1036 NNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILR- 1094
             +  +R+G++ G VL GV+G RK  YD+W N V +A+ ME+ G+ G + + + T   L  
Sbjct: 391  VDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNG 450

Query: 1095 ----EYGFRFVRRGPIFVKGKGELLTFFLKGRDKLATFP 1129
                E G+   R    F+K    + TFF+    +   FP
Sbjct: 451  DYEVEPGYGHERNS--FLK-THNIETFFIVPSHRRKIFP 486


>gi|24497587 adenylate cyclase 4 [Homo sapiens]
          Length = 1077

 Score =  552 bits (1422), Expect = e-157
 Identities = 390/1119 (34%), Positives = 589/1119 (52%), Gaps = 93/1119 (8%)

Query: 59   PESLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLASLAVAGIGLVLD 118
            P S +  Y+TY+   +   LL+L++   L  C +  + AV ++S +  +   + +  VL 
Sbjct: 10   PPSEDLFYETYYSLSQQYPLLLLLLGIVL--CALAALLAVAWASGRELTSDPSFLTTVLC 67

Query: 119  IILFVLCKKGLLP--DRVTR--RVLPYVLWLLITAQIFSYLGLNFARAHAASDTVGWQVF 174
             +       GL     R+ R  R L  ++W+ + A   ++L        +A D V + +F
Sbjct: 68   ALGGFSLLLGLASREQRLQRWTRPLSGLVWVALLALGHAFLFTG--GVVSAWDQVSYFLF 125

Query: 175  FVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREILANVFLYL 234
             +F+ +  LPL +    +  + S + H LVLG+ +  Q         LL ++ AN  L+L
Sbjct: 126  VIFTAYAMLPLGMRDAAVAGLASSLSHLLVLGLYLGPQPDSR---PALLPQLAANAVLFL 182

Query: 235  CAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKD 294
            C    G+    + +R  R  F EA  SL  +  L+ + + QE+L+LSILP ++A EM  +
Sbjct: 183  CGNVAGVYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAE 242

Query: 295  MK------KDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELF 348
            +       +    +    F+++Y+ RH+ VS+L+ADIVGFT+L+S CS +ELV +LNELF
Sbjct: 243  IMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELF 302

Query: 349  ARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTG 408
             +FD++A ++  +RIKILGDCYYC+ GLP    DHA+  + MGL M  AI  +R  T   
Sbjct: 303  GKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVD 362

Query: 409  VDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEF 468
            ++MRVGVH+G+VL GV+G ++WQYDVWS DVT+AN MEAGG+PGRVHI+ +T+  L G +
Sbjct: 363  INMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAY 422

Query: 469  DVEPGDGGSRCDYLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSPAL 528
             VE      R  YL E G  TYL+I  + E +    + G  G  L +          P+L
Sbjct: 423  AVEDAGMEHRDPYLRELGEPTYLVIDPRAEEED---EKGTAGGLLSS---LEGLKMRPSL 476

Query: 529  IETK--EPNGSAHSSGSTSEKPEEQDAQADNP---SFPNPRRRLRLQDLA-----DRVVD 578
            + T+  E  G+A        KP    +  D+P   S P P + L            R   
Sbjct: 477  LMTRYLESWGAA--------KPFAHLSHGDSPVSTSTPLPEKTLASFSTQWSLDRSRTPR 528

Query: 579  ASEDEHELNQLLNEALLERESAQVVKKRNTFL--LSMRFMDPEMETRYSVEKEKQSGAAF 636
              +DE +        ++E+ ++Q   K++     L++ F + EME  Y +          
Sbjct: 529  GLDDELDTGDAKFFQVIEQLNSQKQWKQSKDFNPLTLYFREKEMEKEYRLSAIPAFKYYE 588

Query: 637  SCSCVVLLCTALVEILID---PWLMTNY-VTFMVGEILLLILTICSLAAIFPRAF--PKK 690
            +C+ +V L   ++++L+    P L   Y +TF+   + LLIL +C    +       PK 
Sbjct: 589  ACTFLVFLSNFIIQMLVTNRPPALAITYSITFL---LFLLILFVCFSEDLMRCVLKGPKM 645

Query: 691  L---VAFSTWIDRT---RWARNTWAMLAIFILVMANVVDMLSCLQYYTGPSNATA----- 739
            L    A S  +      R A  T  +L +F + + ++    +         N ++     
Sbjct: 646  LHWLPALSGLVATRPGLRIALGTATILLVFAMAITSLFFFPTSSDCPFQAPNVSSMISNL 705

Query: 740  GMETEGSC-LENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPV 798
              E  GS  L +  Y  +   L  ++  + + +S  +KL L+LL   A  ++ L++    
Sbjct: 706  SWELPGSLPLISVPYSMHCCTLGFLSCSLFLHMSFELKLLLLLLWLAASCSLFLHS---- 761

Query: 799  FDEYDHKRFREHDLPMVALEQMQGFNPGLNGTDRLPLVPSKYSMTVMVFLMMLSFYYFSR 858
                 H    E  +  + L  +    PG+       L   K    +  F+   +    +R
Sbjct: 762  -----HAWLSECLIVRLYLGPLDS-RPGV-------LKEPKLMGAISFFIFFFTLLVLAR 808

Query: 859  HVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQT 918
              E   R  FLWK ++  ++E    M      L+ N+LP HVA  F+G  +R+E+LY Q+
Sbjct: 809  QNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQS 868

Query: 919  YDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIG 978
            Y+ + V+FAS+P+F +FY+E +IN+ G+ECLR LNEII+DFD LL  PKF  + KIKTIG
Sbjct: 869  YECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIG 928

Query: 979  STYMAASGVTPDVNTNGFASSNKEDKSERER-WQHLADLADFALAMKDTLTNINNQSFNN 1037
            STYMAA+G+         A+S ++ + + ER   HL  + +FA+A+   L  IN  SFNN
Sbjct: 929  STYMAATGLN--------ATSGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNN 980

Query: 1038 FMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYG 1097
            F LR+G+N G V+AGVIGA+KP YDIWGNTVNVASRMESTGV+G IQV EET   L+  G
Sbjct: 981  FRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSLG 1040

Query: 1098 FRFVRRGPIFVKGKGELLTFFLKGRDKLATFPNGPSVTL 1136
            +    RG I VKGKG+L T+FL   D   T P  PS TL
Sbjct: 1041 YTCYSRGVIKVKGKGQLCTYFL-NTDLTRTGP--PSATL 1076


>gi|50959205 adenylate cyclase 9 [Homo sapiens]
          Length = 1353

 Score =  380 bits (975), Expect = e-105
 Identities = 304/1011 (30%), Positives = 473/1011 (46%), Gaps = 168/1011 (16%)

Query: 225  EILANVFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILP 284
            E+L+   L+ C  A+G+  + M+  + R  FL+  QS+    +LE +   +E ++ S++P
Sbjct: 280  ELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMP 339

Query: 285  KHVADEMLKD--------------------MKKDESQKDQQQFNTMYMYRHENVSILFAD 324
            + +AD+++K                      KK   QK    F    M + E VSILFAD
Sbjct: 340  RIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFAD 399

Query: 325  IVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHA 384
            IVGFT++S+  SA  LV LLN+LF RFD+L  +    +I  LGDCYYC+ G P+ R DHA
Sbjct: 400  IVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHA 459

Query: 385  VCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANK 444
             C I MGL M++AI    ++ K  V+MRVGVHTGTVL G+LG +R+++DVWS DV +AN 
Sbjct: 460  YCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANL 519

Query: 445  MEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYL----EEKGIETYLIIASKPEVK 500
            ME  G+ G+VHIS++T   L   +++E G    R        + KG++TYLI   + +  
Sbjct: 520  MEQLGVAGKVHISEATAKYLDDRYEMEDGKVIERLGQSVVADQLKGLKTYLISGQRAKES 579

Query: 501  KTATQNGL-------NGSALPNGAPASSKSSS-------------------PALIETKEP 534
            + +    L       +GS + +G      +SS                   P+   T  P
Sbjct: 580  RCSCAEALLSGFEVIDGSQVSSGPRGQGTASSGNVSDLAQTVKTFDNLKTCPSCGITFAP 639

Query: 535  NGSAHSSGSTSEK--PEEQDAQADNPSFPNPRRR-------------------LRLQDLA 573
               A + G   +    +E          PNP+ +                     +    
Sbjct: 640  KSEAGAEGGAPQNGCQDEHKNSTKASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEK 699

Query: 574  DRVVDASEDEHELNQLLNEALLERESAQVVK--KRNTFL-----------LSMRFMDPEM 620
             R    S D+  L  L  + + E+  A  V   K ++ +            S+ F+D E+
Sbjct: 700  GRWAGVSLDQSALLPLRFKNIREKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQEL 759

Query: 621  ETRYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILTICSL- 679
            E  Y    +++       S V    +     L+D +L T         + L + T C L 
Sbjct: 760  ERSYRTSYQEE---VIKNSPVKTFASPTFSSLLDVFLSTT--------VFLTLSTTCFLK 808

Query: 680  --AAIFPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMANVVDMLSC----LQYYTG 733
              AA  P   P  L  FS  +            LA+ I ++  + D+++C    L++  G
Sbjct: 809  YEAATVPPP-PAALAVFSAAL------LLEVLSLAVSIRMVFFLEDVMACTKRLLEWIAG 861

Query: 734  -------------------PSNATAGMETEGSCLENPKYYNYVAVLSLIATIMLVQVSHM 774
                                S+ T+  ET    +  P +    A+++++      Q+S  
Sbjct: 862  WLPRHCIGAILVSLPALAVYSHVTSEYETN---IHFPVFTGSAALIAVVHYCNFCQLSSW 918

Query: 775  VKLTLMLLVAGAVATINLYAWRPVFDEYDHKRFREHDLPMVALEQMQGFNPGLNGTD--- 831
            ++ +L  +V GA   + LY               +  +    L+ +Q F+   N  +   
Sbjct: 919  MRSSLATVV-GAGPLLLLYV----------SLCPDSSVLTSPLDAVQNFSSERNPCNSSV 967

Query: 832  ----RLPLVPSKYSMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRW 887
                R P       + ++ FL++L  ++ +R  E   R  +   +E    + ++  MR  
Sbjct: 968  PRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQ 1027

Query: 888  NEALVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIE 947
             + L+ N++P HVA        +  + YS+ +D  GV+FAS+ NF++FY E     GG E
Sbjct: 1028 ADWLLRNIIPYHVAEQL-----KVSQTYSKNHDSGGVIFASIVNFSEFYEEN--YEGGKE 1080

Query: 948  CLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSER 1007
            C R LNE+I DFD LL  P +  I KIKTIG+TYMAASG+          ++  +D S  
Sbjct: 1081 CYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLN---------TAQAQDGSHP 1131

Query: 1008 ERWQHLADLADFALAMKDTLTNINNQS-FNNFMLRIGMNKGGVLAGVIGARKPHYDIWGN 1066
            +  +HL  L +FA  M   + + NN   + NF LR+G N G + AGVIG  K  YDIWG+
Sbjct: 1132 Q--EHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGD 1189

Query: 1067 TVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTF 1117
            TVN+ASRM++TGV   IQV EE+  +L + G+ F  RG + VKGKG++ T+
Sbjct: 1190 TVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTY 1240



 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 56/250 (22%), Positives = 112/250 (44%), Gaps = 30/250 (12%)

Query: 224  REILANVFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSIL 283
            +E++   FL L  +      + ++ R H    +EA      +  ++    Q + L+ +I+
Sbjct: 980  QEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLH---RTKIQSMRDQADWLLRNII 1036

Query: 284  PKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQL--SSACSAQELV 341
            P HVA+++              + +  Y   H++  ++FA IV F++    +    +E  
Sbjct: 1037 PYHVAEQL--------------KVSQTYSKNHDSGGVIFASIVNFSEFYEENYEGGKECY 1082

Query: 342  KLLNELFARFDKLAAK--YHQL-RIKILGDCYYCICGLP-------DYREDHAVCSILMG 391
            ++LNEL   FD+L +K  Y  + +IK +G  Y    GL         + ++H        
Sbjct: 1083 RVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFA 1142

Query: 392  LAMVEAIS-YVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGI 450
              M+  +  +          +RVG + G +  GV+G  +  YD+W   V +A++M+  G+
Sbjct: 1143 KEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGV 1202

Query: 451  PGRVHISQST 460
              R+ +S+ +
Sbjct: 1203 ECRIQVSEES 1212


>gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens]
          Length = 1047

 Score =  119 bits (298), Expect = 2e-26
 Identities = 84/279 (30%), Positives = 143/279 (51%), Gaps = 41/279 (14%)

Query: 849  MMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSK 908
            ++L    ++ ++EKL          V ++ +   E +R  EAL+  +LP  VA       
Sbjct: 801  LLLRMEQYANNLEKL----------VEERTQAYLEEKRKAEALLYQILPHSVAEQL---- 846

Query: 909  KRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKF 968
            KR E + ++ +D + + F+ +  F    T  S  +  ++ +  LN++ + FD+++DN   
Sbjct: 847  KRGETVQAEAFDSVTIYFSDIVGF----TALSAESTPMQVVTLLNDLYTCFDAIIDNFD- 901

Query: 969  RVITKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLT 1028
              + K++TIG  YM  SG+                   R   +H  ++A  ALA+ D ++
Sbjct: 902  --VYKVETIGDAYMVVSGLPG-----------------RNGQRHAPEIARMALALLDAVS 942

Query: 1029 N--INNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVV 1086
            +  I ++  +   LRIG++ G V AGV+G + P Y ++G+TVN ASRMES G    I V 
Sbjct: 943  SFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVS 1002

Query: 1087 EETQVILREYG-FRFVRRGPIFVKGKGELLTFFLKGRDK 1124
              T+  L E G F+   RG + +KGKG++ T++L G  K
Sbjct: 1003 STTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGERK 1041



 Score =  109 bits (272), Expect = 2e-23
 Identities = 65/198 (32%), Positives = 112/198 (56%), Gaps = 16/198 (8%)

Query: 270  EQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFT 329
            E+ ++ E L+  ILP  VA+++    K+ E         T+     ++V+I F+DIVGFT
Sbjct: 825  EEKRKAEALLYQILPHSVAEQL----KRGE---------TVQAEAFDSVTIYFSDIVGFT 871

Query: 330  QLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYR-EDHAVCSI 388
             LS+  +  ++V LLN+L+  FD +   +   +++ +GD Y  + GLP    + HA    
Sbjct: 872  ALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIA 931

Query: 389  LMGLAMVEAIS--YVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKME 446
             M LA+++A+S   +R +    + +R+GVHTG V  GV+G K  +Y ++   V  A++ME
Sbjct: 932  RMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRME 991

Query: 447  AGGIPGRVHISQSTMDCL 464
            + G   ++H+S +T D L
Sbjct: 992  SNGQALKIHVSSTTKDAL 1009


>gi|167830411 natriuretic peptide receptor 1 [Homo sapiens]
          Length = 1061

 Score =  118 bits (296), Expect = 3e-26
 Identities = 79/251 (31%), Positives = 131/251 (52%), Gaps = 31/251 (12%)

Query: 874  VHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGVMFASLPNFA 933
            V ++ +   E +R  EAL+  +LP  VA       KR E + ++ +D + + F+ +  F 
Sbjct: 831  VEERTQAYLEEKRKAEALLYQILPHSVAEQL----KRGETVQAEAFDSVTIYFSDIVGF- 885

Query: 934  DFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNT 993
               T  S  +  ++ +  LN++ + FD+++DN     + K++TIG  YM  SG+      
Sbjct: 886  ---TALSAESTPMQVVTLLNDLYTCFDAVIDNFD---VYKVETIGDAYMVVSGLPV---- 935

Query: 994  NGFASSNKEDKSERERWQHLADLADFALAMKDTLTN--INNQSFNNFMLRIGMNKGGVLA 1051
                         R    H  ++A  ALA+ D + +  I ++      LRIG++ G V A
Sbjct: 936  -------------RNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCA 982

Query: 1052 GVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREY-GFRFVRRGPIFVKG 1110
            GV+G + P Y ++G+TVN ASRMES G    I +  ET+ +L E+ GF    RG + +KG
Sbjct: 983  GVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKG 1042

Query: 1111 KGELLTFFLKG 1121
            KG++ T++L G
Sbjct: 1043 KGKVRTYWLLG 1053



 Score =  105 bits (261), Expect = 3e-22
 Identities = 64/207 (30%), Positives = 115/207 (55%), Gaps = 18/207 (8%)

Query: 270  EQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFT 329
            E+ ++ E L+  ILP  VA+++    K+ E         T+     ++V+I F+DIVGFT
Sbjct: 840  EEKRKAEALLYQILPHSVAEQL----KRGE---------TVQAEAFDSVTIYFSDIVGFT 886

Query: 330  QLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSIL 389
             LS+  +  ++V LLN+L+  FD +   +   +++ +GD Y  + GLP        C + 
Sbjct: 887  ALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVA 946

Query: 390  -MGLAMVEAIS--YVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKME 446
             M LA+++A+    +R + +  + +R+G+HTG V  GV+G K  +Y ++   V  A++ME
Sbjct: 947  RMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRME 1006

Query: 447  AGGIPGRVHISQSTMDCLK--GEFDVE 471
            + G   ++H+S  T   L+  G F++E
Sbjct: 1007 SNGEALKIHLSSETKAVLEEFGGFELE 1033


>gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Homo
           sapiens]
          Length = 455

 Score =  117 bits (292), Expect = 8e-26
 Identities = 65/198 (32%), Positives = 109/198 (55%), Gaps = 13/198 (6%)

Query: 268 LEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVG 327
           LEE+ ++  +L+ SI P  VA ++              Q   +   +  NV++LF+DIVG
Sbjct: 208 LEEEKKKTVDLLCSIFPCEVAQQLW-------------QGQVVQAKKFSNVTMLFSDIVG 254

Query: 328 FTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCS 387
           FT + S CS  +++ +LN L+ RFD+   +    +++ +GD Y    GL    + HAV  
Sbjct: 255 FTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQI 314

Query: 388 ILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEA 447
            LM L M+E    V       + MR+G+H+G+V  GV+G K  +Y ++  +VT+ANK E+
Sbjct: 315 ALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFES 374

Query: 448 GGIPGRVHISQSTMDCLK 465
             +P ++++S +T   LK
Sbjct: 375 CSVPRKINVSPTTYRLLK 392



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 55/248 (22%), Positives = 108/248 (43%), Gaps = 30/248 (12%)

Query: 857  SRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYS 916
            +R  + L + L   K  +    + + E ++    L+ ++ P  VA+       + + + +
Sbjct: 184  ARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQA 239

Query: 917  QTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKT 976
            + +  + ++F+ +  F    ++ S     ++ +  LN + + FD          + K++T
Sbjct: 240  KKFSNVTMLFSDIVGFTAICSQCS----PLQVITMLNALYTRFDQQCGELD---VYKVET 292

Query: 977  IGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFN 1036
            IG  Y  A G+  + +T                  H   +A  AL M +    + +    
Sbjct: 293  IGDAYCVAGGLHKESDT------------------HAVQIALMALKMMELSDEVMSPHGE 334

Query: 1037 NFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREY 1096
               +RIG++ G V AGV+G + P Y ++GN V +A++ ES  V   I V   T  +L++ 
Sbjct: 335  PIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDC 394

Query: 1097 -GFRFVRR 1103
             GF F  R
Sbjct: 395  PGFVFTPR 402


>gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
           sapiens]
          Length = 690

 Score =  117 bits (292), Expect = 8e-26
 Identities = 65/198 (32%), Positives = 109/198 (55%), Gaps = 13/198 (6%)

Query: 268 LEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVG 327
           LEE+ ++  +L+ SI P  VA ++              Q   +   +  NV++LF+DIVG
Sbjct: 443 LEEEKKKTVDLLCSIFPCEVAQQLW-------------QGQVVQAKKFSNVTMLFSDIVG 489

Query: 328 FTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCS 387
           FT + S CS  +++ +LN L+ RFD+   +    +++ +GD Y    GL    + HAV  
Sbjct: 490 FTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQI 549

Query: 388 ILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEA 447
            LM L M+E    V       + MR+G+H+G+V  GV+G K  +Y ++  +VT+ANK E+
Sbjct: 550 ALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFES 609

Query: 448 GGIPGRVHISQSTMDCLK 465
             +P ++++S +T   LK
Sbjct: 610 CSVPRKINVSPTTYRLLK 627



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 55/248 (22%), Positives = 108/248 (43%), Gaps = 30/248 (12%)

Query: 857  SRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYS 916
            +R  + L + L   K  +    + + E ++    L+ ++ P  VA+       + + + +
Sbjct: 419  ARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQA 474

Query: 917  QTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKT 976
            + +  + ++F+ +  F    ++ S     ++ +  LN + + FD          + K++T
Sbjct: 475  KKFSNVTMLFSDIVGFTAICSQCS----PLQVITMLNALYTRFDQQCGELD---VYKVET 527

Query: 977  IGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFN 1036
            IG  Y  A G+  + +T                  H   +A  AL M +    + +    
Sbjct: 528  IGDAYCVAGGLHKESDT------------------HAVQIALMALKMMELSDEVMSPHGE 569

Query: 1037 NFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREY 1096
               +RIG++ G V AGV+G + P Y ++GN V +A++ ES  V   I V   T  +L++ 
Sbjct: 570  PIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDC 629

Query: 1097 -GFRFVRR 1103
             GF F  R
Sbjct: 630  PGFVFTPR 637


>gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
           sapiens]
          Length = 690

 Score =  117 bits (292), Expect = 8e-26
 Identities = 65/198 (32%), Positives = 109/198 (55%), Gaps = 13/198 (6%)

Query: 268 LEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVG 327
           LEE+ ++  +L+ SI P  VA ++              Q   +   +  NV++LF+DIVG
Sbjct: 443 LEEEKKKTVDLLCSIFPCEVAQQLW-------------QGQVVQAKKFSNVTMLFSDIVG 489

Query: 328 FTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCS 387
           FT + S CS  +++ +LN L+ RFD+   +    +++ +GD Y    GL    + HAV  
Sbjct: 490 FTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQI 549

Query: 388 ILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEA 447
            LM L M+E    V       + MR+G+H+G+V  GV+G K  +Y ++  +VT+ANK E+
Sbjct: 550 ALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFES 609

Query: 448 GGIPGRVHISQSTMDCLK 465
             +P ++++S +T   LK
Sbjct: 610 CSVPRKINVSPTTYRLLK 627



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 55/248 (22%), Positives = 108/248 (43%), Gaps = 30/248 (12%)

Query: 857  SRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYS 916
            +R  + L + L   K  +    + + E ++    L+ ++ P  VA+       + + + +
Sbjct: 419  ARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQA 474

Query: 917  QTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKT 976
            + +  + ++F+ +  F    ++ S     ++ +  LN + + FD          + K++T
Sbjct: 475  KKFSNVTMLFSDIVGFTAICSQCS----PLQVITMLNALYTRFDQQCGELD---VYKVET 527

Query: 977  IGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFN 1036
            IG  Y  A G+  + +T                  H   +A  AL M +    + +    
Sbjct: 528  IGDAYCVAGGLHKESDT------------------HAVQIALMALKMMELSDEVMSPHGE 569

Query: 1037 NFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREY 1096
               +RIG++ G V AGV+G + P Y ++GN V +A++ ES  V   I V   T  +L++ 
Sbjct: 570  PIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDC 629

Query: 1097 -GFRFVRR 1103
             GF F  R
Sbjct: 630  PGFVFTPR 637


>gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
           sapiens]
          Length = 690

 Score =  117 bits (292), Expect = 8e-26
 Identities = 65/198 (32%), Positives = 109/198 (55%), Gaps = 13/198 (6%)

Query: 268 LEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVG 327
           LEE+ ++  +L+ SI P  VA ++              Q   +   +  NV++LF+DIVG
Sbjct: 443 LEEEKKKTVDLLCSIFPCEVAQQLW-------------QGQVVQAKKFSNVTMLFSDIVG 489

Query: 328 FTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCS 387
           FT + S CS  +++ +LN L+ RFD+   +    +++ +GD Y    GL    + HAV  
Sbjct: 490 FTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQI 549

Query: 388 ILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEA 447
            LM L M+E    V       + MR+G+H+G+V  GV+G K  +Y ++  +VT+ANK E+
Sbjct: 550 ALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFES 609

Query: 448 GGIPGRVHISQSTMDCLK 465
             +P ++++S +T   LK
Sbjct: 610 CSVPRKINVSPTTYRLLK 627



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 55/248 (22%), Positives = 108/248 (43%), Gaps = 30/248 (12%)

Query: 857  SRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYS 916
            +R  + L + L   K  +    + + E ++    L+ ++ P  VA+       + + + +
Sbjct: 419  ARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQA 474

Query: 917  QTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKT 976
            + +  + ++F+ +  F    ++ S     ++ +  LN + + FD          + K++T
Sbjct: 475  KKFSNVTMLFSDIVGFTAICSQCS----PLQVITMLNALYTRFDQQCGELD---VYKVET 527

Query: 977  IGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFN 1036
            IG  Y  A G+  + +T                  H   +A  AL M +    + +    
Sbjct: 528  IGDAYCVAGGLHKESDT------------------HAVQIALMALKMMELSDEVMSPHGE 569

Query: 1037 NFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREY 1096
               +RIG++ G V AGV+G + P Y ++GN V +A++ ES  V   I V   T  +L++ 
Sbjct: 570  PIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDC 629

Query: 1097 -GFRFVRR 1103
             GF F  R
Sbjct: 630  PGFVFTPR 637


>gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
           sapiens]
          Length = 690

 Score =  117 bits (292), Expect = 8e-26
 Identities = 65/198 (32%), Positives = 109/198 (55%), Gaps = 13/198 (6%)

Query: 268 LEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVG 327
           LEE+ ++  +L+ SI P  VA ++              Q   +   +  NV++LF+DIVG
Sbjct: 443 LEEEKKKTVDLLCSIFPCEVAQQLW-------------QGQVVQAKKFSNVTMLFSDIVG 489

Query: 328 FTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCS 387
           FT + S CS  +++ +LN L+ RFD+   +    +++ +GD Y    GL    + HAV  
Sbjct: 490 FTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQI 549

Query: 388 ILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEA 447
            LM L M+E    V       + MR+G+H+G+V  GV+G K  +Y ++  +VT+ANK E+
Sbjct: 550 ALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFES 609

Query: 448 GGIPGRVHISQSTMDCLK 465
             +P ++++S +T   LK
Sbjct: 610 CSVPRKINVSPTTYRLLK 627



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 55/248 (22%), Positives = 108/248 (43%), Gaps = 30/248 (12%)

Query: 857  SRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYS 916
            +R  + L + L   K  +    + + E ++    L+ ++ P  VA+       + + + +
Sbjct: 419  ARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQA 474

Query: 917  QTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKT 976
            + +  + ++F+ +  F    ++ S     ++ +  LN + + FD          + K++T
Sbjct: 475  KKFSNVTMLFSDIVGFTAICSQCS----PLQVITMLNALYTRFDQQCGELD---VYKVET 527

Query: 977  IGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFN 1036
            IG  Y  A G+  + +T                  H   +A  AL M +    + +    
Sbjct: 528  IGDAYCVAGGLHKESDT------------------HAVQIALMALKMMELSDEVMSPHGE 569

Query: 1037 NFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREY 1096
               +RIG++ G V AGV+G + P Y ++GN V +A++ ES  V   I V   T  +L++ 
Sbjct: 570  PIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDC 629

Query: 1097 -GFRFVRR 1103
             GF F  R
Sbjct: 630  PGFVFTPR 637


>gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Homo
           sapiens]
          Length = 624

 Score =  115 bits (287), Expect = 3e-25
 Identities = 63/193 (32%), Positives = 107/193 (55%), Gaps = 13/193 (6%)

Query: 268 LEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVG 327
           LEE+ ++  +L+ SI P  VA ++              Q   +   +  NV++LF+DIVG
Sbjct: 443 LEEEKKKTVDLLCSIFPCEVAQQLW-------------QGQVVQAKKFSNVTMLFSDIVG 489

Query: 328 FTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCS 387
           FT + S CS  +++ +LN L+ RFD+   +    +++ +GD Y    GL    + HAV  
Sbjct: 490 FTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQI 549

Query: 388 ILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEA 447
            LM L M+E    V       + MR+G+H+G+V  GV+G K  +Y ++  +VT+ANK E+
Sbjct: 550 ALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFES 609

Query: 448 GGIPGRVHISQST 460
             +P ++++S +T
Sbjct: 610 CSVPRKINVSPTT 622



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 50/233 (21%), Positives = 100/233 (42%), Gaps = 29/233 (12%)

Query: 857  SRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYS 916
            +R  + L + L   K  +    + + E ++    L+ ++ P  VA+       + + + +
Sbjct: 419  ARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQA 474

Query: 917  QTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKT 976
            + +  + ++F+ +  F    ++ S     ++ +  LN + + FD          + K++T
Sbjct: 475  KKFSNVTMLFSDIVGFTAICSQCS----PLQVITMLNALYTRFDQQCGELD---VYKVET 527

Query: 977  IGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFN 1036
            IG  Y  A G+  + +T                  H   +A  AL M +    + +    
Sbjct: 528  IGDAYCVAGGLHKESDT------------------HAVQIALMALKMMELSDEVMSPHGE 569

Query: 1037 NFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEET 1089
               +RIG++ G V AGV+G + P Y ++GN V +A++ ES  V   I V   T
Sbjct: 570  PIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTT 622


>gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens]
          Length = 732

 Score =  113 bits (283), Expect = 9e-25
 Identities = 65/200 (32%), Positives = 112/200 (56%), Gaps = 13/200 (6%)

Query: 268 LEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVG 327
           LEE+ ++  +L+ SI P  VA ++       + Q+ Q +       + ++V++LF+DIVG
Sbjct: 483 LEEEKKKTVDLLYSIFPGDVAQQLW------QGQQVQAR-------KFDDVTMLFSDIVG 529

Query: 328 FTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCS 387
           FT + + C+  +++ +LNEL+ RFD         +++ +GD Y    GL      HA   
Sbjct: 530 FTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPI 589

Query: 388 ILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEA 447
            LM L M+E    V       + MR+G+H+G+VL GV+G +  +Y ++  +VT+A+K E+
Sbjct: 590 ALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFES 649

Query: 448 GGIPGRVHISQSTMDCLKGE 467
           G  P R+++S +T   LK E
Sbjct: 650 GSHPRRINVSPTTYQLLKRE 669



 Score = 75.1 bits (183), Expect = 4e-13
 Identities = 61/247 (24%), Positives = 113/247 (45%), Gaps = 37/247 (14%)

Query: 858  RHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQ 917
            + ++KL  TL      + ++K++  +       L+ ++ P  VA+       + +++ ++
Sbjct: 467  KRMDKLKATLERTHQALEEEKKKTVD-------LLYSIFPGDVAQQLW----QGQQVQAR 515

Query: 918  TYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTI 977
             +D++ ++F+ +  F     + +     ++ +  LNE+ + FD       F  I K++TI
Sbjct: 516  KFDDVTMLFSDIVGFTAICAQCT----PMQVISMLNELYTRFDHQCG---FLDIYKVETI 568

Query: 978  GSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFNN 1037
            G  Y  A+G+                   R+   H   +A  AL M +    +       
Sbjct: 569  GDAYCVAAGL------------------HRKSLCHAKPIALMALKMMELSEEVLTPDGRP 610

Query: 1038 FMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEET-QVILREY 1096
              +RIG++ G VLAGV+G R P Y ++GN V +AS+ ES      I V   T Q++ RE 
Sbjct: 611  IQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKREE 670

Query: 1097 GFRFVRR 1103
             F F+ R
Sbjct: 671  SFTFIPR 677


>gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens]
          Length = 619

 Score =  103 bits (256), Expect = 1e-21
 Identities = 74/280 (26%), Positives = 129/280 (46%), Gaps = 37/280 (13%)

Query: 854  YYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEE 913
            Y  ++ +E L   L L    + D+K++        + L+ ++LP  VA       +    
Sbjct: 363  YKLTQELEILTDRLQLTLRALEDEKKKT-------DTLLYSVLPPSVANEL----RHKRP 411

Query: 914  LYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITK 973
            + ++ YD + ++F+ +  F  F ++ +   G ++ +  LN++ + FD+L D+ K   + K
Sbjct: 412  VPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYK 471

Query: 974  IKTIGSTYMAASGVT-PDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINN 1032
            ++T+G  YM  SG+  P ++                   H   +   AL M +    +  
Sbjct: 472  VETVGDKYMTVSGLPEPCIH-------------------HARSICHLALDMMEIAGQVQV 512

Query: 1033 QSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVI 1092
                +  + IG++ G V+ GVIG R P Y ++GNTVN+ SR E+TG  G I V E T   
Sbjct: 513  DG-ESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRC 571

Query: 1093 L-----REYGFRFVRRGPIFVKGKGELLTFFLKGRDKLAT 1127
            L      +  F    RGP+ +KGK E +  +   R    T
Sbjct: 572  LMSPENSDPQFHLEHRGPVSMKGKKEPMQVWFLSRKNTGT 611



 Score = 97.8 bits (242), Expect = 5e-20
 Identities = 64/212 (30%), Positives = 113/212 (53%), Gaps = 21/212 (9%)

Query: 268 LEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVG 327
           LE++ ++ + L+ S+LP  VA+E+    K+    K           R++NV+ILF+ IVG
Sbjct: 383 LEDEKKKTDTLLYSVLPPSVANELRH--KRPVPAK-----------RYDNVTILFSGIVG 429

Query: 328 FTQL----SSACSAQELVKLLNELFARFDKLAAKYHQ---LRIKILGDCYYCICGLPDYR 380
           F       +S   A ++V LLN+L+ RFD L          +++ +GD Y  + GLP+  
Sbjct: 430 FNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPC 489

Query: 381 EDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVT 440
             HA     + L M+E    V+   ++ V + +G+HTG V+ GV+GQ+  +Y ++   V 
Sbjct: 490 IHHARSICHLALDMMEIAGQVQVDGES-VQITIGIHTGEVVTGVIGQRMPRYCLFGNTVN 548

Query: 441 VANKMEAGGIPGRVHISQSTMDCLKGEFDVEP 472
           + ++ E  G  G++++S+ T  CL    + +P
Sbjct: 549 LTSRTETTGEKGKINVSEYTYRCLMSPENSDP 580


>gi|134152694 guanylate cyclase 2F [Homo sapiens]
          Length = 1108

 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 67/236 (28%), Positives = 118/236 (50%), Gaps = 16/236 (6%)

Query: 268  LEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVG 327
            LE + Q+ E L+  +LP  VA+ + K    +    D              V++ F+DIVG
Sbjct: 846  LEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDL-------------VTLYFSDIVG 892

Query: 328  FTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYR-EDHAVC 386
            FT +S+     E+V LLN+L+  FD +   +   +++ +GD Y    GLP      HA  
Sbjct: 893  FTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAE 952

Query: 387  SILMGLAMVEAIS--YVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANK 444
               M L ++ ++    +R   +  V +R+G+H+G V+ GV+G    +Y ++   V  A++
Sbjct: 953  IANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASR 1012

Query: 445  MEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLEEKGIETYLIIASKPEVK 500
            ME+ G+P R+H+S ST+  L+   +    +   R +   +   ET+ +I  K  +K
Sbjct: 1013 MESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWLIGKKGFMK 1068



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 82/274 (29%), Positives = 137/274 (50%), Gaps = 42/274 (15%)

Query: 860  VEKLARTLFLWKIEVHDQ-KERVYEM---RRWNEALVTNMLPEHVARHFLGSKKRDEELY 915
            ++ + R L  +   + D  +ER  E+   ++  E L+T MLP  VA     S K+   + 
Sbjct: 821  IDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAE----SLKKGCTVE 876

Query: 916  SQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIK 975
             + +D + + F+ +  F    T  S  +  IE +  LN++ + FD+++ +     + K++
Sbjct: 877  PEGFDLVTLYFSDIVGF----TTISAMSEPIEVVDLLNDLYTLFDAIIGSHD---VYKVE 929

Query: 976  TIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSF 1035
            TIG  YM ASG+                  +R   +H A++A+ +L   D L+++     
Sbjct: 930  TIGDAYMVASGLP-----------------KRNGSRHAAEIANMSL---DILSSVGTFKM 969

Query: 1036 NNF-----MLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQ 1090
             +       +RIG++ G V+AGV+G   P Y ++G+TVN ASRMESTG+   I V   T 
Sbjct: 970  RHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTV 1029

Query: 1091 VILREY--GFRFVRRGPIFVKGKGELLTFFLKGR 1122
             IL+    G+    RG   +KGKG   TF+L G+
Sbjct: 1030 TILQNLSEGYEVELRGRTELKGKGTEETFWLIGK 1063


>gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Homo
            sapiens]
          Length = 1103

 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 60/201 (29%), Positives = 108/201 (53%), Gaps = 16/201 (7%)

Query: 268  LEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVG 327
            LE + Q+ + L+  +LP  VA+ +     K  +  + + F        E V++ F+DIVG
Sbjct: 842  LELEKQKTDRLLTQMLPPSVAEAL-----KTGTPVEPEYF--------EQVTLYFSDIVG 888

Query: 328  FTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYR-EDHAVC 386
            FT +S+     E+V LLN+L+  FD +   +   +++ +GD Y    GLP    + HA  
Sbjct: 889  FTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAE 948

Query: 387  SILMGLAMVEAIS--YVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANK 444
               M L ++ A+    +R   +  V +R+G+H+G  + GV+G    +Y ++   V  A++
Sbjct: 949  IANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASR 1008

Query: 445  MEAGGIPGRVHISQSTMDCLK 465
            ME+ G+P R+H++ ST+  L+
Sbjct: 1009 MESTGLPYRIHVNLSTVGILR 1029



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 78/271 (28%), Positives = 135/271 (49%), Gaps = 36/271 (13%)

Query: 860  VEKLARTLFLWKIEVHDQ-KERVYEM---RRWNEALVTNMLPEHVARHFLGSKKRDEELY 915
            ++ + R L  +   + D  +ER  E+   ++  + L+T MLP  VA     + K    + 
Sbjct: 817  IDSMLRMLEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAE----ALKTGTPVE 872

Query: 916  SQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIK 975
             + ++++ + F+ +  F    T  S  +  IE +  LN++ + FD+++ +     + K++
Sbjct: 873  PEYFEQVTLYFSDIVGF----TTISAMSEPIEVVDLLNDLYTLFDAIIGSHD---VYKVE 925

Query: 976  TIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSF 1035
            TIG  YM ASG+                  +R   +H A++A+ +L +   +     +  
Sbjct: 926  TIGDAYMVASGLP-----------------QRNGQRHAAEIANMSLDILSAVGTFRMRHM 968

Query: 1036 NNF--MLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVIL 1093
                  +RIG++ G  +AGV+G   P Y ++G+TVN ASRMESTG+   I V   T  IL
Sbjct: 969  PEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGIL 1028

Query: 1094 R--EYGFRFVRRGPIFVKGKGELLTFFLKGR 1122
            R  + G++   RG   +KGKG   TF+L GR
Sbjct: 1029 RALDSGYQVELRGRTELKGKGAEDTFWLVGR 1059


>gi|222080083 guanylate cyclase 2C [Homo sapiens]
          Length = 1073

 Score = 97.4 bits (241), Expect = 7e-20
 Identities = 80/284 (28%), Positives = 136/284 (47%), Gaps = 35/284 (12%)

Query: 859  HVEKLARTLFLWKIEVH---DQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELY 915
            +++ L R L L+   +    +++ ++Y+  R     +  ML   + R  + S K    + 
Sbjct: 760  YMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFML---LPRLVVKSLKEKGFVE 816

Query: 916  SQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIK 975
             + Y+E+ + F+ +  F       +     +E +  LN+I   FD ++D+     + K++
Sbjct: 817  PELYEEVTIYFSDIVGFTTICKYST----PMEVVDMLNDIYKSFDHIVDHHD---VYKVE 869

Query: 976  TIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSF 1035
            TIG  YM ASG+ P  N N                +H  D+A  AL +   +     +  
Sbjct: 870  TIGDAYMVASGL-PKRNGN----------------RHAIDIAKMALEILSFMGTFELEHL 912

Query: 1036 NNF--MLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVIL 1093
                  +RIG++ G   AGV+G + P Y ++G+TVN ASRMESTG+   I V   T  IL
Sbjct: 913  PGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAIL 972

Query: 1094 R--EYGFRFVRRGPIFVKGKGELLTFFLKG-RDKLATFPNGPSV 1134
            +  E  F +  RG  ++KG+G   T++L G +D+    P  P+V
Sbjct: 973  KRTECQFLYEVRGETYLKGRGNETTYWLTGMKDQKFNLPTPPTV 1016



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 57/180 (31%), Positives = 96/180 (53%), Gaps = 13/180 (7%)

Query: 315 HENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCIC 374
           +E V+I F+DIVGFT +    +  E+V +LN+++  FD +   +   +++ +GD Y    
Sbjct: 820 YEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVAS 879

Query: 375 GLPDYRED-HAVCSILMGLAMVEAISYVREKTKTGVD--MRVGVHTGTVLGGVLGQKRWQ 431
           GLP    + HA+    M L ++  +     +   G+   +R+GVH+G    GV+G K  +
Sbjct: 880 GLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPR 939

Query: 432 YDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLEEKGIETYL 491
           Y ++   V  A++ME+ G+P R+H+S ST+  LK           + C +L E   ETYL
Sbjct: 940 YCLFGDTVNTASRMESTGLPLRIHVSGSTIAILK----------RTECQFLYEVRGETYL 989


>gi|197313748 SET domain containing 2 [Homo sapiens]
          Length = 2564

 Score = 42.4 bits (98), Expect = 0.003
 Identities = 45/202 (22%), Positives = 85/202 (42%), Gaps = 31/202 (15%)

Query: 456  ISQSTMDCLKGEF--DVEPGDGGSRCDYLEEKGIET-------YLIIASKPEVKKTATQN 506
            IS+++MD    +   ++E  DG    D LE   +E         L+    PE K  +  N
Sbjct: 1884 ISENSMDSAISDATSELEGKDGKEDLDQLENVPVEEEEELQSQQLLPQQLPECKVDSETN 1943

Query: 507  GLNGSALPNGAPASSKSSSPALIETKEPNGSAHSSGSTSEKPEEQDAQA-----DNPSFP 561
             +  S LP   P +      A IE KE NG+        E P + + +         S  
Sbjct: 1944 -IEASKLPTSEPEAD-----AEIEPKESNGTKLEEPINEETPSQDEEEGVSDVESERSQE 1997

Query: 562  NPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLL---------- 611
             P + + + DLA +++D+ +D  E+ ++  ++  E+E+    + R+              
Sbjct: 1998 QPDKTVDISDLATKLLDSWKDLKEVYRIPKKSQTEKENTTTERGRDAVGFRDQTPAPKTP 2057

Query: 612  -SMRFMDPEMETRYSVEKEKQS 632
               R  DP+ +T+   +++++S
Sbjct: 2058 NRSRERDPDKQTQNKEKRKRRS 2079


>gi|76150625 nucleolar protein 1, 120kDa [Homo sapiens]
          Length = 808

 Score = 35.8 bits (81), Expect = 0.24
 Identities = 35/135 (25%), Positives = 57/135 (42%), Gaps = 7/135 (5%)

Query: 497 PEVKKTATQNGLNGSALPNGAPASSKSSSPALIETKEPNGSAHSSGSTSEKPEEQDAQAD 556
           P+  K+     L G  LP GA  ++    P  +    P G    +  + E+ EE+D++ D
Sbjct: 62  PKTNKSPEAKPLPGK-LPKGAVQTAGKKGPQSL-FNAPRGKKRPAPGSDEEEEEEDSEED 119

Query: 557 NPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLLSMRFM 616
                N       +D AD V D   D +  ++   EALL  E A   +K       +++ 
Sbjct: 120 --GMVNHGDLWGSEDDADTVDDYGADSNSEDEEEGEALLPIERAARKQKAREAAAGIQWS 177

Query: 617 DPEMETRYSVEKEKQ 631
           + E E     E+EK+
Sbjct: 178 EEETEDE---EEEKE 189


>gi|76150623 nucleolar protein 1, 120kDa [Homo sapiens]
          Length = 808

 Score = 35.8 bits (81), Expect = 0.24
 Identities = 35/135 (25%), Positives = 57/135 (42%), Gaps = 7/135 (5%)

Query: 497 PEVKKTATQNGLNGSALPNGAPASSKSSSPALIETKEPNGSAHSSGSTSEKPEEQDAQAD 556
           P+  K+     L G  LP GA  ++    P  +    P G    +  + E+ EE+D++ D
Sbjct: 62  PKTNKSPEAKPLPGK-LPKGAVQTAGKKGPQSL-FNAPRGKKRPAPGSDEEEEEEDSEED 119

Query: 557 NPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLLSMRFM 616
                N       +D AD V D   D +  ++   EALL  E A   +K       +++ 
Sbjct: 120 --GMVNHGDLWGSEDDADTVDDYGADSNSEDEEEGEALLPIERAARKQKAREAAAGIQWS 177

Query: 617 DPEMETRYSVEKEKQ 631
           + E E     E+EK+
Sbjct: 178 EEETEDE---EEEKE 189


>gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]
          Length = 1083

 Score = 34.3 bits (77), Expect = 0.70
 Identities = 28/98 (28%), Positives = 47/98 (47%), Gaps = 12/98 (12%)

Query: 535 NGSAHSSGSTSEKPEEQDAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEAL 594
           + S H S S SE   E+  +AD PS P    RL +  + +  +   + + + N LLN  L
Sbjct: 358 SASCHDSASDSE---EESEEADKPSSPED-GRLSVSYITEECLKKLDTKQQTNTLLN--L 411

Query: 595 LERESAQ------VVKKRNTFLLSMRFMDPEMETRYSV 626
           + R+SA       +    +T ++  R M P++   YS+
Sbjct: 412 VWRDSASEEVFTTMASVCHTLMVQHRMMVPKVRLLYSL 449


>gi|32483374 nucleolar protein 5A [Homo sapiens]
          Length = 594

 Score = 33.5 bits (75), Expect = 1.2
 Identities = 22/69 (31%), Positives = 35/69 (50%), Gaps = 4/69 (5%)

Query: 483 EEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASS----KSSSPALIETKEPNGSA 538
           +E G+E   I  SKP+ KK+ ++  L  S L   A ++S    K S+P      +P  + 
Sbjct: 492 QENGMEDPSISFSKPKKKKSFSKEELMSSDLEETAGSTSIPKRKKSTPKEETVNDPEEAG 551

Query: 539 HSSGSTSEK 547
           H SGS  ++
Sbjct: 552 HRSGSKKKR 560


>gi|38788260 bromodomain PHD finger transcription factor isoform 2
            [Homo sapiens]
          Length = 2903

 Score = 33.5 bits (75), Expect = 1.2
 Identities = 41/160 (25%), Positives = 63/160 (39%), Gaps = 8/160 (5%)

Query: 400  YVREKTKTGVDMRVGVHTGTVLGGVLGQKR--WQYDVWSTDVTVANKMEAGGIPGRVHIS 457
            Y   +   G+  R  + T   L GV    R  W    W     +A K   GG   R   S
Sbjct: 1882 YPSPRPTFGITWRYRLQTVKSLAGVSLMLRLLWASLRWDD---MAAKAPPGGGTTRTETS 1938

Query: 458  QSTMDCLKGEFDVEPGDGGSRCDYLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGA 517
            ++ +   +     + G  G R +Y   K I   + +   P+   T  + GL  SAL    
Sbjct: 1939 ETEITTTEIIKRRDVGPYGIRSEYCIRK-IICPIGVPETPKETPTPQRKGLRSSALRPKR 1997

Query: 518  PASSKSSSPALIET--KEPNGSAHSSGSTSEKPEEQDAQA 555
            P + K + P +IET   E         + +E+ E++ AQA
Sbjct: 1998 PETPKQTGPVIIETWVAEEELELWEIRAFAERVEKEKAQA 2037


>gi|38788274 bromodomain PHD finger transcription factor isoform 1
            [Homo sapiens]
          Length = 2920

 Score = 33.5 bits (75), Expect = 1.2
 Identities = 41/160 (25%), Positives = 63/160 (39%), Gaps = 8/160 (5%)

Query: 400  YVREKTKTGVDMRVGVHTGTVLGGVLGQKR--WQYDVWSTDVTVANKMEAGGIPGRVHIS 457
            Y   +   G+  R  + T   L GV    R  W    W     +A K   GG   R   S
Sbjct: 1756 YPSPRPTFGITWRYRLQTVKSLAGVSLMLRLLWASLRWDD---MAAKAPPGGGTTRTETS 1812

Query: 458  QSTMDCLKGEFDVEPGDGGSRCDYLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGA 517
            ++ +   +     + G  G R +Y   K I   + +   P+   T  + GL  SAL    
Sbjct: 1813 ETEITTTEIIKRRDVGPYGIRSEYCIRK-IICPIGVPETPKETPTPQRKGLRSSALRPKR 1871

Query: 518  PASSKSSSPALIET--KEPNGSAHSSGSTSEKPEEQDAQA 555
            P + K + P +IET   E         + +E+ E++ AQA
Sbjct: 1872 PETPKQTGPVIIETWVAEEELELWEIRAFAERVEKEKAQA 1911


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.136    0.400 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,557,016
Number of Sequences: 37866
Number of extensions: 1750466
Number of successful extensions: 6713
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 29
Number of HSP's successfully gapped in prelim test: 33
Number of HSP's that attempted gapping in prelim test: 6476
Number of HSP's gapped (non-prelim): 140
length of query: 1144
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1031
effective length of database: 13,968,660
effective search space: 14401688460
effective search space used: 14401688460
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.