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Search of human proteins with 14780904
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14780904 kelch-like 1 protein [Homo sapiens]
(748 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14780904 kelch-like 1 protein [Homo sapiens] 1535 0.0
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 958 0.0
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 942 0.0
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 942 0.0
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 932 0.0
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 857 0.0
gi|40807500 kelch-like 20 [Homo sapiens] 495 e-140
gi|38194229 kelch-like 17 [Homo sapiens] 451 e-126
gi|55925604 kelch-like 18 [Homo sapiens] 429 e-120
gi|166235129 kelch-like 3 [Homo sapiens] 422 e-118
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 416 e-116
gi|34101268 kelch-like 8 [Homo sapiens] 414 e-115
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 412 e-115
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 412 e-115
gi|11056006 kelch-like 12 [Homo sapiens] 408 e-114
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 369 e-102
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 360 3e-99
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 360 3e-99
gi|148664209 kelch-like 10 [Homo sapiens] 328 1e-89
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 317 3e-86
gi|223890235 intracisternal A particle-promoted polypeptide isof... 305 1e-82
gi|45643138 kelch-like 13 [Homo sapiens] 267 3e-71
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 264 3e-70
gi|24308181 kelch-like 9 [Homo sapiens] 264 3e-70
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens] 259 6e-69
gi|40018614 DRE1 protein [Homo sapiens] 256 7e-68
gi|24475847 influenza virus NS1A binding protein [Homo sapiens] 254 3e-67
gi|8922854 kelch-like 26 [Homo sapiens] 253 3e-67
gi|109150407 kelch-like 6 [Homo sapiens] 240 3e-63
gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 233 4e-61
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 1535 bits (3973), Expect = 0.0
Identities = 748/748 (100%), Positives = 748/748 (100%)
Query: 1 MSGSGRKDFDVKHILRLRWKLFSHPSPSTGGPAGGGCLQQDGSGSFEHWGPSQSRLLKSQ 60
MSGSGRKDFDVKHILRLRWKLFSHPSPSTGGPAGGGCLQQDGSGSFEHWGPSQSRLLKSQ
Sbjct: 1 MSGSGRKDFDVKHILRLRWKLFSHPSPSTGGPAGGGCLQQDGSGSFEHWGPSQSRLLKSQ 60
Query: 61 ERSGVSTFWKKPSSSSSSSSSPSSSSSSFNPLNGTLLPVATRLQQGAPGQGTQQPARTLF 120
ERSGVSTFWKKPSSSSSSSSSPSSSSSSFNPLNGTLLPVATRLQQGAPGQGTQQPARTLF
Sbjct: 61 ERSGVSTFWKKPSSSSSSSSSPSSSSSSFNPLNGTLLPVATRLQQGAPGQGTQQPARTLF 120
Query: 121 YVESLEEEVVPGMDFPGPHEKGLVLQELKVEPDNSSQATGEGCGHRLSSTGHSMTPQSDL 180
YVESLEEEVVPGMDFPGPHEKGLVLQELKVEPDNSSQATGEGCGHRLSSTGHSMTPQSDL
Sbjct: 121 YVESLEEEVVPGMDFPGPHEKGLVLQELKVEPDNSSQATGEGCGHRLSSTGHSMTPQSDL 180
Query: 181 DSSSSEEFYQAVHHAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAM 240
DSSSSEEFYQAVHHAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAM
Sbjct: 181 DSSSSEEFYQAVHHAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAM 240
Query: 241 FTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEV 300
FTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEV
Sbjct: 241 FTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEV 300
Query: 301 CCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHK 360
CCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHK
Sbjct: 301 CCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHK 360
Query: 361 LLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILADLENHALF 420
LLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILADLENHALF
Sbjct: 361 LLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILADLENHALF 420
Query: 421 KNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATTIEKYD 480
KNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATTIEKYD
Sbjct: 421 KNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATTIEKYD 480
Query: 481 LRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMS 540
LRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMS
Sbjct: 481 LRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMS 540
Query: 541 THRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNG 600
THRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNG
Sbjct: 541 THRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNG 600
Query: 601 KLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPAS 660
KLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPAS
Sbjct: 601 KLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPAS 660
Query: 661 NHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESY 720
NHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESY
Sbjct: 661 NHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESY 720
Query: 721 DPQTNEWTQMASLNIGRAGACVVVIKQP 748
DPQTNEWTQMASLNIGRAGACVVVIKQP
Sbjct: 721 DPQTNEWTQMASLNIGRAGACVVVIKQP 748
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 958 bits (2477), Expect = 0.0
Identities = 488/753 (64%), Positives = 578/753 (76%), Gaps = 40/753 (5%)
Query: 1 MSGSGRKDFDVKHILRLRWKLFSHPSPSTGGPAGGGCLQQDGSGSFEHWG-PSQSRLLK- 58
MS SG+K+FDVK ILRLRW+ FSHP G G CLQQ+G +EH G P Q RL
Sbjct: 1 MSVSGKKEFDVKQILRLRWRWFSHPFQ--GSTNTGSCLQQEG---YEHRGTPVQGRLKSH 55
Query: 59 SQERSGVSTFWKKPSSSSSSSSSPSSSSSSFNPLNGTLLPVATRLQQGAPGQGTQQPART 118
S++R+G+ S+SP + L PV Q
Sbjct: 56 SRDRNGLK-----------KSNSPVH--------HNILAPVPGPAPAHQRAVQNLQQHNL 96
Query: 119 LFYVESLEE--EVVPGMD-FPGPHEKGLVLQELKVEPDNSSQATGEGCGHRLSSTGHSMT 175
+ + ++ E+ + VP + F EK E+ + DN +T T HS
Sbjct: 97 IVHFQANEDTPKSVPEKNLFKEACEKRAQDLEMMAD-DNIEDSTAR------LDTQHS-- 147
Query: 176 PQSDLDSSSSEEFYQAVHHAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSD 235
D++++ SEE + ++HAEQT RKME+YLK++QLCDV+LI G+ +IPAHRLVLS+VSD
Sbjct: 148 --EDMNATRSEEQFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSD 205
Query: 236 YFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLP 295
YFAAMFT+DV EAKQEE++MEG+DPNAL LVQ+AYTG L+LKEDTIE+LLAAACLLQL
Sbjct: 206 YFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLT 265
Query: 296 QVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPA 355
QV++VC +FL+K LHPSNCLGIR+F DAQGC EL+ VAH YTME+ +EVI+NQEFLLLPA
Sbjct: 266 QVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPA 325
Query: 356 EELHKLLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILADLE 415
E+ KLL SDD+NVPDEETIFHALM WV +D+Q+R +L MLL++IRLPLLPPQ+LADLE
Sbjct: 326 NEISKLLCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLADLE 385
Query: 416 NHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATT 475
++F DLECQKL++EAMKYHLLPERR++MQSPRTKPRKSTVG LYAVGGMD KG TT
Sbjct: 386 TSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTT 445
Query: 476 IEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTV 535
IEKYDLRTN W+ G MNGRRLQFGVAVID+KL+V+GGRDGLKTLNTVEC+NP K WTV
Sbjct: 446 IEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTV 505
Query: 536 LPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGV 595
+PPMSTHRHGLGV LEGP+YAVGGHDGWSYLNTVERWDP+ +QW +VASMS RSTVGV
Sbjct: 506 MPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGV 565
Query: 596 AALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGH 655
ALN KLY++GGRDGSSCL SMEY+DPHTNKW++CAPM KRRGGVGVAT +GFLY VGGH
Sbjct: 566 VALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGH 625
Query: 656 DAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLN 715
DAPASNHCSRL D VERYDPK D+W+ VAPLS+PRDAV VC LGD+LY VGGYDG TYLN
Sbjct: 626 DAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLN 685
Query: 716 TMESYDPQTNEWTQMASLNIGRAGACVVVIKQP 748
T+ESYD Q NEW + +NIGRAGACVVV+K P
Sbjct: 686 TVESYDAQRNEWKEEVPVNIGRAGACVVVVKLP 718
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 942 bits (2434), Expect = 0.0
Identities = 473/748 (63%), Positives = 568/748 (75%), Gaps = 42/748 (5%)
Query: 1 MSGSGRKDFDVKHILRLRWKLFSHPSPSTGGPAGGGCLQQDGSGSFEHWGPSQSRLLKSQ 60
MSGS RK+FDVK IL++RW+ F H + S Q G E W Q+
Sbjct: 1 MSGS-RKEFDVKQILKIRWRWFGHQASSPNSTVDS----QQG----EFWNRGQTGA---- 47
Query: 61 ERSGVSTFWKKPSSSSSSSSSPSSSSSSFNPLNGTLLPVATRLQQGAPGQGTQQPARTLF 120
+G F S +S SS + N P+A+ +
Sbjct: 48 --NGGRKFLDPCSLQLPLASIGYRRSSQLDFQNSPSWPMASTSE---------------- 89
Query: 121 YVESLEEEVVPGMDFPGPHEKGLVLQELKVEPDNSSQATGEGCGH--RLSSTGHSMTPQS 178
VP +F G + D +S+ E R S++ +++
Sbjct: 90 ---------VPAFEFTAEDCGGAHWLDRPEVDDGTSEEENESDSSSCRTSNSSQTLSSCH 140
Query: 179 DLDSSSSEEFYQAVHHAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFA 238
++ +S+EF+QA++HAEQTF+KME+YL+ +QLCDVIL+ G+R+IPAHRLVLSSVSDYFA
Sbjct: 141 TMEPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFA 200
Query: 239 AMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVV 298
AMFT+DV EA+QEEIKMEG++PN+LW L+Q+AYTG LELKED IE LL+ ACLLQL QVV
Sbjct: 201 AMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVV 260
Query: 299 EVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEEL 358
E CC FLMK LHPSNCLGIR+FADAQGC +L KVAH+YTME+ MEVIRNQEF+LLPA E+
Sbjct: 261 EACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEI 320
Query: 359 HKLLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILADLENHA 418
KLLASDD+N+P+EETI +AL+ WV++D++ R DLS LLA+IRLPLL PQ LAD+EN+
Sbjct: 321 AKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADMENNV 380
Query: 419 LFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATTIEK 478
LF++D+ECQKLI+EAMKYHLLPERR ++QSPRTKPRKSTVGTL+AVGGMD+ KGAT+IEK
Sbjct: 381 LFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEK 440
Query: 479 YDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPP 538
YDLRTN+W MNGRRLQFGVAV+DDKL+V+GGRDGLKTLNTVECYNPKTKTW+V+PP
Sbjct: 441 YDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPP 500
Query: 539 MSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAAL 598
MSTHRHGLGV VLEGP+YAVGGHDGWSYLNTVERWDPQ++QW FVA+MS RSTVGVA L
Sbjct: 501 MSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVL 560
Query: 599 NGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAP 658
+GKLY+VGGRDGSSCL S+E +DPHTNKW +CA M KRRGGVGV T +G LYA+GGHDAP
Sbjct: 561 SGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAP 620
Query: 659 ASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTME 718
ASN SRL D VERYDPKTD WT VA +S+ RDAVGVCLLGD+LYAVGGYDGQ YLNT+E
Sbjct: 621 ASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVE 680
Query: 719 SYDPQTNEWTQMASLNIGRAGACVVVIK 746
+YDPQTNEWTQ+A L +GRAGACVV +K
Sbjct: 681 AYDPQTNEWTQVAPLCLGRAGACVVTVK 708
Score = 76.3 bits (186), Expect = 1e-13
Identities = 41/102 (40%), Positives = 61/102 (59%), Gaps = 6/102 (5%)
Query: 647 GFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVG 706
G L+AVGG D+ ++ +E+YD +T+ WT VA ++ R GV +L D+LY VG
Sbjct: 421 GTLFAVGGMDS------TKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVG 474
Query: 707 GYDGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVVIKQP 748
G DG LNT+E Y+P+T W+ M ++ R G V V++ P
Sbjct: 475 GRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGP 516
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 942 bits (2434), Expect = 0.0
Identities = 473/748 (63%), Positives = 568/748 (75%), Gaps = 42/748 (5%)
Query: 1 MSGSGRKDFDVKHILRLRWKLFSHPSPSTGGPAGGGCLQQDGSGSFEHWGPSQSRLLKSQ 60
MSGS RK+FDVK IL++RW+ F H + S Q G E W Q+
Sbjct: 47 MSGS-RKEFDVKQILKIRWRWFGHQASSPNSTVDS----QQG----EFWNRGQTGA---- 93
Query: 61 ERSGVSTFWKKPSSSSSSSSSPSSSSSSFNPLNGTLLPVATRLQQGAPGQGTQQPARTLF 120
+G F S +S SS + N P+A+ +
Sbjct: 94 --NGGRKFLDPCSLQLPLASIGYRRSSQLDFQNSPSWPMASTSE---------------- 135
Query: 121 YVESLEEEVVPGMDFPGPHEKGLVLQELKVEPDNSSQATGEGCGH--RLSSTGHSMTPQS 178
VP +F G + D +S+ E R S++ +++
Sbjct: 136 ---------VPAFEFTAEDCGGAHWLDRPEVDDGTSEEENESDSSSCRTSNSSQTLSSCH 186
Query: 179 DLDSSSSEEFYQAVHHAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFA 238
++ +S+EF+QA++HAEQTF+KME+YL+ +QLCDVIL+ G+R+IPAHRLVLSSVSDYFA
Sbjct: 187 TMEPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFA 246
Query: 239 AMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVV 298
AMFT+DV EA+QEEIKMEG++PN+LW L+Q+AYTG LELKED IE LL+ ACLLQL QVV
Sbjct: 247 AMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVV 306
Query: 299 EVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEEL 358
E CC FLMK LHPSNCLGIR+FADAQGC +L KVAH+YTME+ MEVIRNQEF+LLPA E+
Sbjct: 307 EACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEI 366
Query: 359 HKLLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILADLENHA 418
KLLASDD+N+P+EETI +AL+ WV++D++ R DLS LLA+IRLPLL PQ LAD+EN+
Sbjct: 367 AKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADMENNV 426
Query: 419 LFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATTIEK 478
LF++D+ECQKLI+EAMKYHLLPERR ++QSPRTKPRKSTVGTL+AVGGMD+ KGAT+IEK
Sbjct: 427 LFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEK 486
Query: 479 YDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPP 538
YDLRTN+W MNGRRLQFGVAV+DDKL+V+GGRDGLKTLNTVECYNPKTKTW+V+PP
Sbjct: 487 YDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPP 546
Query: 539 MSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAAL 598
MSTHRHGLGV VLEGP+YAVGGHDGWSYLNTVERWDPQ++QW FVA+MS RSTVGVA L
Sbjct: 547 MSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVL 606
Query: 599 NGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAP 658
+GKLY+VGGRDGSSCL S+E +DPHTNKW +CA M KRRGGVGV T +G LYA+GGHDAP
Sbjct: 607 SGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAP 666
Query: 659 ASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTME 718
ASN SRL D VERYDPKTD WT VA +S+ RDAVGVCLLGD+LYAVGGYDGQ YLNT+E
Sbjct: 667 ASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVE 726
Query: 719 SYDPQTNEWTQMASLNIGRAGACVVVIK 746
+YDPQTNEWTQ+A L +GRAGACVV +K
Sbjct: 727 AYDPQTNEWTQVAPLCLGRAGACVVTVK 754
Score = 76.3 bits (186), Expect = 1e-13
Identities = 41/102 (40%), Positives = 61/102 (59%), Gaps = 6/102 (5%)
Query: 647 GFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVG 706
G L+AVGG D+ ++ +E+YD +T+ WT VA ++ R GV +L D+LY VG
Sbjct: 467 GTLFAVGGMDS------TKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVG 520
Query: 707 GYDGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVVIKQP 748
G DG LNT+E Y+P+T W+ M ++ R G V V++ P
Sbjct: 521 GRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGP 562
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 932 bits (2410), Expect = 0.0
Identities = 475/734 (64%), Positives = 563/734 (76%), Gaps = 40/734 (5%)
Query: 1 MSGSGRKDFDVKHILRLRWKLFSHPSPSTGGPAGGGCLQQDGSGSFEHWG-PSQSRLLK- 58
MS SG+K+FDVK ILRLRW+ FSHP G G CLQQ+G +EH G P Q RL
Sbjct: 1 MSVSGKKEFDVKQILRLRWRWFSHPFQ--GSTNTGSCLQQEG---YEHRGTPVQGRLKSH 55
Query: 59 SQERSGVSTFWKKPSSSSSSSSSPSSSSSSFNPLNGTLLPVATRLQQGAPGQGTQQPART 118
S++R+G+ S+SP + L PV Q
Sbjct: 56 SRDRNGLK-----------KSNSPVH--------HNILAPVPGPAPAHQRAVQNLQQHNL 96
Query: 119 LFYVESLEE--EVVPGMD-FPGPHEKGLVLQELKVEPDNSSQATGEGCGHRLSSTGHSMT 175
+ + ++ E+ + VP + F EK E+ + DN +T T HS
Sbjct: 97 IVHFQANEDTPKSVPEKNLFKEACEKRAQDLEMMAD-DNIEDSTAR------LDTQHS-- 147
Query: 176 PQSDLDSSSSEEFYQAVHHAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSD 235
D++++ SEE + ++HAEQT RKME+YLK++QLCDV+LI G+ +IPAHRLVLS+VSD
Sbjct: 148 --EDMNATRSEEQFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSD 205
Query: 236 YFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLP 295
YFAAMFT+DV EAKQEE++MEG+DPNAL LVQ+AYTG L+LKEDTIE+LLAAACLLQL
Sbjct: 206 YFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLT 265
Query: 296 QVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPA 355
QV++VC +FL+K LHPSNCLGIR+F DAQGC EL+ VAH YTME+ +EVI+NQEFLLLPA
Sbjct: 266 QVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPA 325
Query: 356 EELHKLLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILADLE 415
E+ KLL SDD+NVPDEETIFHALM WV +D+Q+R +L MLL++IRLPLLPPQ+LADLE
Sbjct: 326 NEISKLLCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLADLE 385
Query: 416 NHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATT 475
++F DLECQKL++EAMKYHLLPERR++MQSPRTKPRKSTVG LYAVGGMD KG TT
Sbjct: 386 TSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTT 445
Query: 476 IEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTV 535
IEKYDLRTN W+ G MNGRRLQFGVAVID+KL+V+GGRDGLKTLNTVEC+NP K WTV
Sbjct: 446 IEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTV 505
Query: 536 LPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGV 595
+PPMSTHRHGLGV LEGP+YAVGGHDGWSYLNTVERWDP+ +QW +VASMS RSTVGV
Sbjct: 506 MPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGV 565
Query: 596 AALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGH 655
ALN KLY++GGRDGSSCL SMEY+DPHTNKW++CAPM KRRGGVGVAT +GFLY VGGH
Sbjct: 566 VALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGH 625
Query: 656 DAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLN 715
DAPASNHCSRL D VERYDPK D+W+ VAPLS+PRDAV VC LGD+LY VGGYDG TYLN
Sbjct: 626 DAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLN 685
Query: 716 TMESYDPQTNEWTQ 729
T+ESYD Q NEW +
Sbjct: 686 TVESYDAQRNEWKE 699
Score = 159 bits (401), Expect = 1e-38
Identities = 80/190 (42%), Positives = 115/190 (60%), Gaps = 6/190 (3%)
Query: 553 GPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSS 612
G +YAVGG D T+E++D ++ W + +M+ R GVA ++ KLY VGGRDG
Sbjct: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLK 488
Query: 613 CLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVER 672
L+++E ++P W + PM R G+GVAT +G +YAVGGHD + L+ VER
Sbjct: 489 TLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWS------YLNTVER 542
Query: 673 YDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMAS 732
+DP+ W VA +S PR VGV L ++LYA+GG DG + L +ME +DP TN+W+ A
Sbjct: 543 WDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAP 602
Query: 733 LNIGRAGACV 742
++ R G V
Sbjct: 603 MSKRRGGVGV 612
Score = 107 bits (268), Expect = 3e-23
Identities = 58/146 (39%), Positives = 82/146 (56%), Gaps = 6/146 (4%)
Query: 600 GKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPA 659
G LY+VGG D +++E YD TN W M RR GVA D LY VGG D
Sbjct: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDG-- 486
Query: 660 SNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMES 719
+ L+ VE ++P WT++ P+S R +GV L +YAVGG+DG +YLNT+E
Sbjct: 487 ----LKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVER 542
Query: 720 YDPQTNEWTQMASLNIGRAGACVVVI 745
+DP+ +W +AS++ R+ VV +
Sbjct: 543 WDPEGRQWNYVASMSTPRSTVGVVAL 568
Score = 67.0 bits (162), Expect = 6e-11
Identities = 42/135 (31%), Positives = 68/135 (50%), Gaps = 11/135 (8%)
Query: 614 LSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERY 673
+ +M+Y+ + M +P K R + G LYAVGG DA +E+Y
Sbjct: 401 MEAMKYHLLPERRSMMQSPRTKPR-----KSTVGALYAVGGMDAMKGTTT------IEKY 449
Query: 674 DPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASL 733
D +T++W + ++ R GV ++ ++LY VGG DG LNT+E ++P WT M +
Sbjct: 450 DLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPM 509
Query: 734 NIGRAGACVVVIKQP 748
+ R G V ++ P
Sbjct: 510 STHRHGLGVATLEGP 524
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 857 bits (2213), Expect = 0.0
Identities = 404/520 (77%), Positives = 464/520 (89%)
Query: 227 RLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLL 286
RLVLSSVSDYFAAMFT+DV EA+QEEIKMEG++PN+LW L+Q+AYTG LELKED IE LL
Sbjct: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
Query: 287 AAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIR 346
+ ACLLQL QVVE CC FLMK LHPSNCLGIR+FADAQGC +L KVAH+YTME+ MEVIR
Sbjct: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
Query: 347 NQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLL 406
NQEF+LLPA E+ KLLASDD+N+P+EETI +AL+ WV++D++ R DLS LLA+IRLPLL
Sbjct: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353
Query: 407 PPQILADLENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGG 466
PQ LAD+EN+ LF++D+ECQKLI+EAMKYHLLPERR ++QSPRTKPRKSTVGTL+AVGG
Sbjct: 354 APQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGG 413
Query: 467 MDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECY 526
MD+ KGAT+IEKYDLRTN+W MNGRRLQFGVAV+DDKL+V+GGRDGLKTLNTVECY
Sbjct: 414 MDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECY 473
Query: 527 NPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASM 586
NPKTKTW+V+PPMSTHRHGLGV VLEGP+YAVGGHDGWSYLNTVERWDPQ++QW FVA+M
Sbjct: 474 NPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATM 533
Query: 587 SIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCD 646
S RSTVGVA L+GKLY+VGGRDGSSCL S+E +DPHTNKW +CA M KRRGGVGV T +
Sbjct: 534 STPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWN 593
Query: 647 GFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVG 706
G LYA+GGHDAPASN SRL D VERYDPKTD WT VA +S+ RDAVGVCLLGD+LYAVG
Sbjct: 594 GLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVG 653
Query: 707 GYDGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVVIK 746
GYDGQ YLNT+E+YDPQTNEWTQ+A L +GRAGACVV +K
Sbjct: 654 GYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVK 693
Score = 76.3 bits (186), Expect = 1e-13
Identities = 41/102 (40%), Positives = 61/102 (59%), Gaps = 6/102 (5%)
Query: 647 GFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVG 706
G L+AVGG D+ ++ +E+YD +T+ WT VA ++ R GV +L D+LY VG
Sbjct: 406 GTLFAVGGMDS------TKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVG 459
Query: 707 GYDGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVVIKQP 748
G DG LNT+E Y+P+T W+ M ++ R G V V++ P
Sbjct: 460 GRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGP 501
Score = 37.4 bits (85), Expect = 0.051
Identities = 17/28 (60%), Positives = 22/28 (78%), Gaps = 1/28 (3%)
Query: 1 MSGSGRKDFDVKHILRLRWKLFSHPSPS 28
MSGS RK+FDVK IL++RW+ F H + S
Sbjct: 47 MSGS-RKEFDVKQILKIRWRWFGHQASS 73
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 495 bits (1274), Expect = e-140
Identities = 257/562 (45%), Positives = 356/562 (63%), Gaps = 10/562 (1%)
Query: 189 YQAVHHAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEA 248
Y + H QT + K ++LCDV+L+VG +KI AHR++LS+ S YF AMFT ++ E+
Sbjct: 45 YISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAES 104
Query: 249 KQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKL 308
+Q E+ + ID A+ L+ FAYT + ++E ++ LL AACLLQL ++ E CC FL +
Sbjct: 105 RQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQ 164
Query: 309 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVN 368
L PSNCLGIRAFAD C EL+++A +T N EV+ ++EF+LLPA +L +++SD++N
Sbjct: 165 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELN 224
Query: 369 VPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQIL-ADLENHALFKNDLECQ 427
V EE +F+A+M WVKY +Q R L +L +RLPLL P+ L + + L K+D EC+
Sbjct: 225 VRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECR 284
Query: 428 KLILEAMKYHLLPERRTLMQSPRTKPRK--STVGTLYAVGGMDNNKGATTIEKYDLRTNL 485
L+ EA Y LLP+ R LMQ PRT+PRK L+AVGG + +++E+YD +TN
Sbjct: 285 DLVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNE 344
Query: 486 WIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTV-LPPMSTHRH 544
W M+ RR GV+V+DD L+ +GG DG LN+VE Y+PKT W+ + P ST R
Sbjct: 345 WRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRT 404
Query: 545 GLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYS 604
+GV VL G +YAVGG DG S LN VER+DP+ +WT VASMS R V VA L G LY+
Sbjct: 405 SVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYA 464
Query: 605 VGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCS 664
VGG DG+S L+++E Y+P N+W+ APM RR +G A +YAVGG D
Sbjct: 465 VGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTE---- 520
Query: 665 RLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQT 724
L ERY+P+T+ W+ V ++ R VG+ ++ +L AVGG+DG TYL T+E +DP
Sbjct: 521 --LSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDA 578
Query: 725 NEWTQMASLNIGRAGACVVVIK 746
N W +N R G V VIK
Sbjct: 579 NTWRLYGGMNYRRLGGGVGVIK 600
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 451 bits (1159), Expect = e-126
Identities = 240/589 (40%), Positives = 352/589 (59%), Gaps = 22/589 (3%)
Query: 161 EGCGHRLSSTGHSMTPQSDLDSSSSEEFYQAVHHAEQTFRKMESYLKQQQLCDVILIVGN 220
EG LS GHS+ S H F M ++ LCD++L V
Sbjct: 54 EGAVQLLSREGHSVAHNSK-------------RHYHDAFVAMSRMRQRGLLCDIVLHVAA 100
Query: 221 RKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKED 280
++I AH++VL+S S YF AMFT+++ E++Q + + IDP AL LVQFAYT + + E
Sbjct: 101 KEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEG 160
Query: 281 TIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMEN 340
++ LL AA LLQL V + CC FL+ L PSNCLGIR FADA C +L+K AH Y +++
Sbjct: 161 NVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADAHSCSDLLKAAHRYVLQH 220
Query: 341 IMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAF 400
++V + +EF+LLP +++ +L++SD +NVP EE ++ A++ WVK+D+ +R + L+
Sbjct: 221 FVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEEVYRAVLSWVKHDVDARRQHVPRLMKC 280
Query: 401 IRLPLLPPQ-ILADLENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRK--ST 457
+RLPLL +L ++ +L ++ +C+ L++EA+K+HLLPE+R ++ + RT+PR+
Sbjct: 281 VRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLLPEQRGVLGTSRTRPRRCEGA 340
Query: 458 VGTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGL 517
L+AVGG E YD RT+ W M+ RR + GVA + ++L+ +GG DG
Sbjct: 341 GPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGT 400
Query: 518 KTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQS 577
L TVE Y+P T TW M T R LGV L G +Y+ GG+DG S LN+ ER+DP +
Sbjct: 401 SDLATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLT 460
Query: 578 QQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRR 637
WT VA+MS R V VA L+G LY+VGG D SS L+++E Y+P N W+ A M RR
Sbjct: 461 GTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRR 520
Query: 638 GGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCL 697
GVA +G LY GG+D + L+ VERY PK W VAP+++ R +
Sbjct: 521 SSAGVAVLEGALYVAGGNDG------TSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVA 574
Query: 698 LGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVVIK 746
+ LYAVGG DG + LN++E Y+P+TN+W + + R+ V V++
Sbjct: 575 MDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVLE 623
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 429 bits (1103), Expect = e-120
Identities = 230/567 (40%), Positives = 335/567 (59%), Gaps = 15/567 (2%)
Query: 185 SEEFYQAVHHA-----EQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAA 239
+EE VH + + + ME +Q +LCDV L +G+ K AHR+VL++ YF A
Sbjct: 6 AEELEDLVHFSVSELPSRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHA 65
Query: 240 MFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVE 299
MFT+D+ E KQ+EI M+G+DP+AL L+ FAY G L + + +++LL A LQL + +
Sbjct: 66 MFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKD 125
Query: 300 VCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELH 359
CC FL + LHP NCLG+R FA+ C L A+S+ ++ +EV ++EFL LP E++
Sbjct: 126 ACCTFLRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVL 185
Query: 360 KLLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILAD-LENHA 418
+L++ D++NV EE +F A + WV+YD + R L LL+ IRLPL PQ L+D ++
Sbjct: 186 ELVSRDELNVKSEEQVFEAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDD 245
Query: 419 LFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPR--KSTVGTLYAVGGMDN-NKGATT 475
L + +C+ L+ EA YHL+PERR + + RT+PR S G +YAVGG+++
Sbjct: 246 LVRCCHKCRDLVDEAKDYHLMPERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNV 305
Query: 476 IEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTV 535
+E +D N W + M R + GVAV++ L+ IGG DG L+TVE YNP+T TWT
Sbjct: 306 VEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTR 365
Query: 536 LPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGV 595
+ M++ R +G VL+G IY GG+DG S L++VE + P++ +WT V SMS RS GV
Sbjct: 366 VGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGV 425
Query: 596 AALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGH 655
G++Y GG DG SS+E+Y+ HT W+ A M +R G A+ ++ GG+
Sbjct: 426 TVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGY 485
Query: 656 DAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLN 715
D S L E Y D W ++ P+ R V + RLYAVGGYDGQ+ L+
Sbjct: 486 DG------SGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLS 539
Query: 716 TMESYDPQTNEWTQMASLNIGRAGACV 742
++E YDP+T+ WT MA + G V
Sbjct: 540 SVEMYDPETDCWTFMAPMACHEGGVGV 566
Score = 121 bits (304), Expect = 2e-27
Identities = 59/151 (39%), Positives = 92/151 (60%), Gaps = 7/151 (4%)
Query: 597 ALNGKLYSVGGRDGSS-CLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGH 655
++ G +Y+VGG + + L+ +E +DP N W C PM R VGVA +G LYA+GG+
Sbjct: 285 SIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGY 344
Query: 656 DAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLN 715
D L VE Y+P+TDTWT V ++ R A+G +L ++Y GGYDG + L+
Sbjct: 345 DGQLR------LSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLS 398
Query: 716 TMESYDPQTNEWTQMASLNIGRAGACVVVIK 746
++E+Y P+T++WT + S++ R+ A V V +
Sbjct: 399 SVETYSPETDKWTVVTSMSSNRSAAGVTVFE 429
Score = 100 bits (248), Expect = 6e-21
Identities = 51/140 (36%), Positives = 77/140 (55%)
Query: 459 GTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLK 518
G +Y GG D + +++E Y+ T W A M +R + G A + K+FV GG DG
Sbjct: 430 GRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSG 489
Query: 519 TLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQ 578
L+ E Y+ W ++ PM T R + + G +YAVGG+DG S L++VE +DP++
Sbjct: 490 FLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETD 549
Query: 579 QWTFVASMSIARSTVGVAAL 598
WTF+A M+ VGV +
Sbjct: 550 CWTFMAPMACHEGGVGVGCI 569
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 422 bits (1086), Expect = e-118
Identities = 228/559 (40%), Positives = 338/559 (60%), Gaps = 14/559 (2%)
Query: 194 HAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEI 253
H + F+ M +Q LCDV+++ + +I AHR+VL++ S YF AMFT D+ E+K ++I
Sbjct: 32 HMGKAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKI 91
Query: 254 KMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSN 313
+++ +D L L+ + YT +E+ E+ ++ LL AA LLQL V + CC FL LHP+N
Sbjct: 92 EIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTN 151
Query: 314 CLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEE 373
CLGIRAFAD C +L++ A++Y ++ EV+ +EFL L +++ L++SD + V EE
Sbjct: 152 CLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEE 211
Query: 374 TIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILAD-LENHALFKNDLECQKLILE 432
+F A++ W+ Y+ ++R ++ L+ +RLPLLP L +E AL KN+ C+ ++E
Sbjct: 212 KVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIE 271
Query: 433 AMKYHLLP-ERRTLMQSPRTKPRK--STVGTLYAVGGMDNNKGATTIEKYDLRTNLWIQA 489
AMKYHLLP ++R L+++PRTKPR S + VGG K ++E YD + W Q
Sbjct: 272 AMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGG-QAPKAIRSVECYDFEEDRWDQI 330
Query: 490 GMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVT 549
+ RR + GV + ++ +GG +G + TV+ Y+ WT + M R LG
Sbjct: 331 AELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAA 390
Query: 550 VLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRD 609
VL +YAVGG DG + L +VE + ++ +W FVA M+ RS+VGV + GKLY+VGG D
Sbjct: 391 VLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYD 450
Query: 610 GSS--CLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLL 667
G+S CLS++E Y+P TN+W A M RR G GV G LYA GGHD P +
Sbjct: 451 GASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPL------VR 504
Query: 668 DYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEW 727
VE YDP T+TW VA ++M R GVC + LY VGG DG L ++E Y+P T++W
Sbjct: 505 KSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKW 564
Query: 728 TQM-ASLNIGRAGACVVVI 745
T + +++ GR+ A V VI
Sbjct: 565 TLLPTNMSTGRSYAGVAVI 583
Score = 91.3 bits (225), Expect = 3e-18
Identities = 52/146 (35%), Positives = 77/146 (52%), Gaps = 6/146 (4%)
Query: 601 KLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPAS 660
K+ V G + S+E YD ++W+ A + RR GV G +YAVGG +
Sbjct: 301 KVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNG--- 357
Query: 661 NHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESY 720
S + V+ YD D WT +A + R +G +L D LYAVGG+DG T L ++E+Y
Sbjct: 358 ---SLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAY 414
Query: 721 DPQTNEWTQMASLNIGRAGACVVVIK 746
+TNEW +A +N R+ V V++
Sbjct: 415 SYKTNEWFFVAPMNTRRSSVGVGVVE 440
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 416 bits (1069), Expect = e-116
Identities = 226/555 (40%), Positives = 333/555 (60%), Gaps = 27/555 (4%)
Query: 194 HAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEI 253
H+EQ + + + +LCD+IL VG+ KI AH++VL+SVS YF AMFT ++ E + E+
Sbjct: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEV 76
Query: 254 KMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSN 313
+ + ID AL +V++AYTG + + +DT+E+LL AA LLQ+ V++ CC FL L P N
Sbjct: 77 EFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGN 136
Query: 314 CLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEE 373
C+GI FA+ GC +L A Y +N V + +EF L +L +++++D +NV EE
Sbjct: 137 CIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEE 196
Query: 374 TIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILADL-ENHALFKNDLECQKLILE 432
T+F+AL W+KYD+Q R L+ LL +RLPLL + L L E + L ++D C+ L+ E
Sbjct: 197 TVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNE 256
Query: 433 AMKYHLLPERR-----TLMQSPRTKPRKSTVGTLYAVGGMDNNKGA-TTIEKYDLRTNLW 486
A+KYH +PE R LM PR P+ L AVGG ++E Y + + W
Sbjct: 257 ALKYHFMPEHRLSHQTVLMTRPRCAPK-----VLCAVGGKSGLFACLDSVEMYFPQNDSW 311
Query: 487 IQAGMMNGRRLQFGVAVIDDKLFVIGG-----RDGL---KTLNTVECYNPKTKTWTVLPP 538
I +N R +FG+ V+D K++VIGG R G+ K N+VEC+NP T TWT L
Sbjct: 312 IGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLER 371
Query: 539 MSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAAL 598
M+ R LGV VL G +YA+GG+DG SYL +VE++ P+ ++W VA M+ RS A L
Sbjct: 372 MNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVL 431
Query: 599 NGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAP 658
+G +Y++GG G + ++S+E YDP + W M A M +R GV GF++ VGGH+
Sbjct: 432 DGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGV 490
Query: 659 ASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTME 718
+ L +ERYDP + WT+ P+ PR VG ++ + LY VGG+ G +YLNT++
Sbjct: 491 SH------LSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQ 544
Query: 719 SYDPQTNEWTQMASL 733
YDP ++ W A +
Sbjct: 545 KYDPISDTWLDSAGM 559
Score = 131 bits (329), Expect = 3e-30
Identities = 75/209 (35%), Positives = 110/209 (52%), Gaps = 7/209 (3%)
Query: 440 PERRTLMQSPRTKPRKSTVGT------LYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMN 493
P+ T R +ST+G LYA+GG D ++EKY + W M
Sbjct: 361 PDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMT 420
Query: 494 GRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEG 553
R F AV+D ++ IGG G +N+VE Y+P +W ++ M+ R GV V+ G
Sbjct: 421 TTRSCFAAAVLDGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLG 479
Query: 554 PIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSC 613
I+ VGGH+G S+L+++ER+DP QWT M R+ VG A ++ LY VGG GSS
Sbjct: 480 FIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSY 539
Query: 614 LSSMEYYDPHTNKWNMCAPMCKRRGGVGV 642
L++++ YDP ++ W A M R G+
Sbjct: 540 LNTVQKYDPISDTWLDSAGMIYCRCNFGL 568
Score = 112 bits (280), Expect = 1e-24
Identities = 55/140 (39%), Positives = 80/140 (57%), Gaps = 1/140 (0%)
Query: 459 GTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLK 518
G +YA+GG ++E+YD + W M +R+ FGV V+ +FV+GG +G+
Sbjct: 433 GMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVS 491
Query: 519 TLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQ 578
L+++E Y+P WTV PM R G+G V++ +Y VGGH G SYLNTV+++DP S
Sbjct: 492 HLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISD 551
Query: 579 QWTFVASMSIARSTVGVAAL 598
W A M R G+ AL
Sbjct: 552 TWLDSAGMIYCRCNFGLTAL 571
Score = 89.0 bits (219), Expect = 1e-17
Identities = 49/147 (33%), Positives = 79/147 (53%), Gaps = 3/147 (2%)
Query: 602 LYSVGGRDGS-SCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGG--HDAP 658
L +VGG+ G +CL S+E Y P + W AP+ R G+ D +Y +GG +
Sbjct: 285 LCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVR 344
Query: 659 ASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTME 718
+ + VE ++P T+TWT + ++ R +GV +L LYA+GGYDGQ+YL ++E
Sbjct: 345 PGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVE 404
Query: 719 SYDPQTNEWTQMASLNIGRAGACVVVI 745
Y P+ +W +A + R+ V+
Sbjct: 405 KYIPKIRKWQPVAPMTTTRSCFAAAVL 431
Score = 64.3 bits (155), Expect = 4e-10
Identities = 35/94 (37%), Positives = 49/94 (52%)
Query: 458 VGTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGL 517
+G ++ VGG + ++IE+YD N W M R G AVID+ L+V+GG G
Sbjct: 478 LGFIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGS 537
Query: 518 KTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVL 551
LNTV+ Y+P + TW M R G+T L
Sbjct: 538 SYLNTVQKYDPISDTWLDSAGMIYCRCNFGLTAL 571
Score = 32.7 bits (73), Expect = 1.3
Identities = 29/86 (33%), Positives = 40/86 (46%), Gaps = 11/86 (12%)
Query: 663 CSRLLDYVERYD--PKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQ-TYLNTMES 719
C LL+ +Y P+ ++ PR A V L AVGG G L+++E
Sbjct: 250 CKHLLNEALKYHFMPEHRLSHQTVLMTRPRCAPKV------LCAVGGKSGLFACLDSVEM 303
Query: 720 YDPQTNEWTQMASLNIGR--AGACVV 743
Y PQ + W +A LNI R G CV+
Sbjct: 304 YFPQNDSWIGLAPLNIPRYEFGICVL 329
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 414 bits (1065), Expect = e-115
Identities = 225/570 (39%), Positives = 331/570 (58%), Gaps = 12/570 (2%)
Query: 181 DSSSSEEFYQAVHHAEQTFR-KMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAA 239
D + F + A + F + + + +LCDV L VG++ I H+LVL+ V YF A
Sbjct: 35 DGDGEDSFIFEANEAWKDFHGSLLRFYENGELCDVTLKVGSKLISCHKLVLACVIPYFRA 94
Query: 240 MFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVE 299
MF S++ EAKQ I++ D +A+ DLV+F Y+ L L D ++ LL AAC+LQ+ V
Sbjct: 95 MFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVAR 154
Query: 300 VCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELH 359
CC ++ HPSNCL +RAFA++ I+LM +A Y ++ EV+ ++F+ + + LH
Sbjct: 155 ACCEYMKLHFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLH 214
Query: 360 KLLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILAD-LENHA 418
KLL+S D+N+ +E+ +++A + W+ + Q L LA +RLPLLP L +
Sbjct: 215 KLLSSSDLNIENEKQVYNAAIKWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQ 274
Query: 419 LFKNDLECQKLILEAMKYHLLPERRTLMQ---SPRTKPRKSTVGTLYAVGGMDNNKGA-T 474
+ K +L+C+ L+ EA YHL R + S RT PRK T G L+ VGG +
Sbjct: 275 IVKQNLKCRDLLDEARNYHLHLSSRAVPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFR 334
Query: 475 TIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWT 534
+IE Y + N W MN RR GV ++ K++ +GG DG + L ++E ++P T W
Sbjct: 335 SIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWM 394
Query: 535 VLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVG 594
+ M+T R G+ + L GPIYA+GG D + N VER+D +S QW+ VA M+ R VG
Sbjct: 395 MKASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVG 454
Query: 595 VAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGG 654
AL +Y+VGG DG + LSS+E YDPH +KW M +RR G GV+ G LY VGG
Sbjct: 455 SVALVNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGG 514
Query: 655 HDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYL 714
D + L VERYDP+++ W VA L+ PR VG+ + +++AVGG++G YL
Sbjct: 515 FDDNSP------LSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYL 568
Query: 715 NTMESYDPQTNEWTQMASLNIGRAGACVVV 744
NT+E++DP N W + S++ RAGA V V
Sbjct: 569 NTVEAFDPVLNRWELVGSVSHCRAGAGVAV 598
Score = 154 bits (389), Expect = 3e-37
Identities = 70/187 (37%), Positives = 116/187 (62%)
Query: 459 GTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLK 518
G +YA+GG+D+N +E+YD+ ++ W MN R G + + ++ +GG DG+
Sbjct: 413 GPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMA 472
Query: 519 TLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQ 578
+L++VE Y+P W + M R G GV+ L G +Y VGG D S L++VER+DP+S
Sbjct: 473 SLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSN 532
Query: 579 QWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRG 638
+W +VA+++ R VG+A + GK+++VGG +G++ L+++E +DP N+W + + R
Sbjct: 533 KWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRA 592
Query: 639 GVGVATC 645
G GVA C
Sbjct: 593 GAGVAVC 599
Score = 63.2 bits (152), Expect = 9e-10
Identities = 34/102 (33%), Positives = 51/102 (50%), Gaps = 5/102 (4%)
Query: 647 GFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVG 706
G L+ VGG S +E Y ++W ++ R VGV + ++YAVG
Sbjct: 318 GVLFCVGGRGGSGDPFRS-----IECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVG 372
Query: 707 GYDGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVVIKQP 748
G+DG +L +ME +DP TN+W AS+N R G + + P
Sbjct: 373 GHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGP 414
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 412 bits (1058), Expect = e-115
Identities = 224/561 (39%), Positives = 334/561 (59%), Gaps = 12/561 (2%)
Query: 194 HAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEI 253
H ++ F+ M Q LCDV ++ + +I AHR+VL++ S YF AMFT ++ E++ + +
Sbjct: 42 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 101
Query: 254 KMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSN 313
+++ +D L L+ + YT +++ E+ ++ LL AA LLQL V + CC FL LHP N
Sbjct: 102 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 161
Query: 314 CLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEE 373
CLGIRAFAD C +L+ A++Y ++ +V+ ++EFL L E++ L++SD + + EE
Sbjct: 162 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 221
Query: 374 TIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILAD-LENHALFKNDLECQKLILE 432
+F A++ WV +D R ++ L+ +RLPLLP + L +E AL KN C+ ++E
Sbjct: 222 KVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIE 281
Query: 433 AMKYHLLP-ERRTLMQSPRTKPR-KSTVGTLYAVGGMDNNKGATTIEKYDLRTNLWIQAG 490
AMKYHLLP E+R LM+S RT+ R + L V G K ++E YD + W Q
Sbjct: 282 AMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVA 341
Query: 491 MMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTV 550
+ RR + G+ + +F +GG +G + TV+ Y+P WT + M R LG V
Sbjct: 342 ELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAV 401
Query: 551 LEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDG 610
L G +YAVGG DG + L++VE ++ +S +W VA M+ RS+VGV + G LY+VGG DG
Sbjct: 402 LNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDG 461
Query: 611 SS--CLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLD 668
+S CLS++E Y+ TN+W A M RR G GV + LYAVGGHD P +
Sbjct: 462 ASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL------VRK 515
Query: 669 YVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWT 728
VE YDP T+ W VA ++M R GVC + LY VGG DG L ++E Y+P T++WT
Sbjct: 516 SVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWT 575
Query: 729 QMAS-LNIGRAGACVVVIKQP 748
++S ++ GR+ A V VI +P
Sbjct: 576 VVSSCMSTGRSYAGVTVIDKP 596
Score = 78.2 bits (191), Expect = 3e-14
Identities = 44/96 (45%), Positives = 55/96 (57%), Gaps = 1/96 (1%)
Query: 461 LYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTL 520
LYAVGG D ++E YD TN W Q MN R GV ++ L+V+GG DG L
Sbjct: 502 LYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNL 561
Query: 521 NTVECYNPKTKTWTVLPP-MSTHRHGLGVTVLEGPI 555
+VE YNP T WTV+ MST R GVTV++ P+
Sbjct: 562 ASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL 597
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 412 bits (1058), Expect = e-115
Identities = 224/561 (39%), Positives = 334/561 (59%), Gaps = 12/561 (2%)
Query: 194 HAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEI 253
H ++ F+ M Q LCDV ++ + +I AHR+VL++ S YF AMFT ++ E++ + +
Sbjct: 38 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 97
Query: 254 KMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSN 313
+++ +D L L+ + YT +++ E+ ++ LL AA LLQL V + CC FL LHP N
Sbjct: 98 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 157
Query: 314 CLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEE 373
CLGIRAFAD C +L+ A++Y ++ +V+ ++EFL L E++ L++SD + + EE
Sbjct: 158 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 217
Query: 374 TIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILAD-LENHALFKNDLECQKLILE 432
+F A++ WV +D R ++ L+ +RLPLLP + L +E AL KN C+ ++E
Sbjct: 218 KVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIE 277
Query: 433 AMKYHLLP-ERRTLMQSPRTKPR-KSTVGTLYAVGGMDNNKGATTIEKYDLRTNLWIQAG 490
AMKYHLLP E+R LM+S RT+ R + L V G K ++E YD + W Q
Sbjct: 278 AMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVA 337
Query: 491 MMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTV 550
+ RR + G+ + +F +GG +G + TV+ Y+P WT + M R LG V
Sbjct: 338 ELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAV 397
Query: 551 LEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDG 610
L G +YAVGG DG + L++VE ++ +S +W VA M+ RS+VGV + G LY+VGG DG
Sbjct: 398 LNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDG 457
Query: 611 SS--CLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLD 668
+S CLS++E Y+ TN+W A M RR G GV + LYAVGGHD P +
Sbjct: 458 ASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL------VRK 511
Query: 669 YVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWT 728
VE YDP T+ W VA ++M R GVC + LY VGG DG L ++E Y+P T++WT
Sbjct: 512 SVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWT 571
Query: 729 QMAS-LNIGRAGACVVVIKQP 748
++S ++ GR+ A V VI +P
Sbjct: 572 VVSSCMSTGRSYAGVTVIDKP 592
Score = 78.2 bits (191), Expect = 3e-14
Identities = 44/96 (45%), Positives = 55/96 (57%), Gaps = 1/96 (1%)
Query: 461 LYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTL 520
LYAVGG D ++E YD TN W Q MN R GV ++ L+V+GG DG L
Sbjct: 498 LYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNL 557
Query: 521 NTVECYNPKTKTWTVLPP-MSTHRHGLGVTVLEGPI 555
+VE YNP T WTV+ MST R GVTV++ P+
Sbjct: 558 ASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL 593
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 408 bits (1049), Expect = e-114
Identities = 212/559 (37%), Positives = 317/559 (56%), Gaps = 11/559 (1%)
Query: 194 HAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEI 253
HA+ M S K LCDV L V + PAHR+VL++ SDYF AMFTS++ E + +
Sbjct: 15 HAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYV 74
Query: 254 KMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSN 313
++G+ + + L+ F YT + + + ++ LL AACLLQL V + CC FL L PSN
Sbjct: 75 DIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSN 134
Query: 314 CLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEE 373
CLGIR FA+ C++LM+ A ++ ++ EV++++EF+LL E+ KL+ D++ V EE
Sbjct: 135 CLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEE 194
Query: 374 TIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILAD-LENHALFKNDLECQKLILE 432
+F A++ WVK+ + R L LL ++R+PLL P+ + D ++ + L+C+ L+ E
Sbjct: 195 PVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDE 254
Query: 433 AMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKG-ATTIEKYDLRTNLWIQAGM 491
A K+HL PE R+ MQ PRT+ R L VGG + + +EKYD +T W
Sbjct: 255 AKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPS 314
Query: 492 MNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYN---PKTKTWTVLPPMSTHRHGLGV 548
+ +R + D+++VIGG DG L++VEC + + W + PM+ R G
Sbjct: 315 ITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGA 374
Query: 549 TVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGR 608
T L IY GG DG ++ER+DP QW+ + M AR G+ +G +Y +GG
Sbjct: 375 TTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGY 434
Query: 609 DGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLD 668
DG + L+S+E YDPHT W PM +R G GVA + +Y VGG D A L
Sbjct: 435 DGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAH------LS 488
Query: 669 YVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWT 728
VE Y+ +TD+WT V ++ PR VG +L RLYA+ GYDG + L+++E YDP + W
Sbjct: 489 SVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWE 548
Query: 729 QMASLNIGRAGACVVVIKQ 747
+ S+ R A V V+++
Sbjct: 549 VVTSMGTQRCDAGVCVLRE 567
Score = 114 bits (286), Expect = 3e-25
Identities = 57/143 (39%), Positives = 82/143 (57%)
Query: 459 GTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLK 518
G +Y +GG D ++EKYD T W M +R GVA+++D ++V+GG DG
Sbjct: 426 GVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTA 485
Query: 519 TLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQ 578
L++VE YN +T +WT + M+T R +G TVL G +YA+ G+DG S L+++E +DP
Sbjct: 486 HLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIID 545
Query: 579 QWTFVASMSIARSTVGVAALNGK 601
W V SM R GV L K
Sbjct: 546 SWEVVTSMGTQRCDAGVCVLREK 568
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 369 bits (946), Expect = e-102
Identities = 203/508 (39%), Positives = 301/508 (59%), Gaps = 12/508 (2%)
Query: 247 EAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLM 306
E++ + ++++ +D L L+ + YT +++ E+ ++ LL AA LLQL V + CC FL
Sbjct: 3 ESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLE 62
Query: 307 KLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDD 366
LHP NCLGIRAFAD C +L+ A++Y ++ +V+ ++EFL L E++ L++SD
Sbjct: 63 SQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDK 122
Query: 367 VNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILAD-LENHALFKNDLE 425
+ + EE +F A++ WV +D R ++ L+ +RLPLLP + L +E AL KN
Sbjct: 123 LTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSA 182
Query: 426 CQKLILEAMKYHLLP-ERRTLMQSPRTKPR-KSTVGTLYAVGGMDNNKGATTIEKYDLRT 483
C+ ++EAMKYHLLP E+R LM+S RT+ R + L V G K ++E YD +
Sbjct: 183 CKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKE 242
Query: 484 NLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHR 543
W Q + RR + G+ + +F +GG +G + TV+ Y+P WT + M R
Sbjct: 243 ERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRR 302
Query: 544 HGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLY 603
LG VL G +YAVGG DG + L++VE ++ +S +W VA M+ RS+VGV + G LY
Sbjct: 303 STLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLY 362
Query: 604 SVGGRDGSS--CLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASN 661
+VGG DG+S CLS++E Y+ TN+W A M RR G GV + LYAVGGHD P
Sbjct: 363 AVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL-- 420
Query: 662 HCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYD 721
+ VE YDP T+ W VA ++M R GVC + LY VGG DG L ++E Y+
Sbjct: 421 ----VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYN 476
Query: 722 PQTNEWTQMAS-LNIGRAGACVVVIKQP 748
P T++WT ++S ++ GR+ A V VI +P
Sbjct: 477 PTTDKWTVVSSCMSTGRSYAGVTVIDKP 504
Score = 78.2 bits (191), Expect = 3e-14
Identities = 44/96 (45%), Positives = 55/96 (57%), Gaps = 1/96 (1%)
Query: 461 LYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTL 520
LYAVGG D ++E YD TN W Q MN R GV ++ L+V+GG DG L
Sbjct: 410 LYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNL 469
Query: 521 NTVECYNPKTKTWTVLPP-MSTHRHGLGVTVLEGPI 555
+VE YNP T WTV+ MST R GVTV++ P+
Sbjct: 470 ASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL 505
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 360 bits (923), Expect = 3e-99
Identities = 207/571 (36%), Positives = 306/571 (53%), Gaps = 23/571 (4%)
Query: 189 YQAVHHAEQTFRKMESYLKQQQLCDVILIVGNRKIPA-----HRLVLSSVSDYFAAMFTS 243
Y H +Q F M QQLCDV L V + PA H++VL+S S F AMFT+
Sbjct: 54 YTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTN 113
Query: 244 DVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCH 303
+ E E + +EGI P + L++FAYT + + E + +++ A + Q+ VV C
Sbjct: 114 GLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSD 173
Query: 304 FLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLA 363
FL++ L PSN +GI FA+ GC+EL + A Y + EV + +EF L +L L++
Sbjct: 174 FLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLIS 233
Query: 364 SDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQIL-ADLENHALFKN 422
DD+NV E +FHA + WVKYD + R + LL +R L P L L+ + ++
Sbjct: 234 RDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQS 293
Query: 423 DLECQKLILEAMKYHLLPERRTLMQSPRTKP-RKSTVGTLYAVGGMDNNKGATTIEKYDL 481
D C+ +++ E TL + + P R VG L G + + +E Y+
Sbjct: 294 DSRCKDYLVKIF------EELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNP 347
Query: 482 RTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGR----DGLKTLNTVECYNPKTKTWTVLP 537
W++ + R V+ L+ +GGR DG + ++CYNP T W+
Sbjct: 348 SDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCA 407
Query: 538 PMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAA 597
PMS R+ +GV V++G IYAVGG G + N+VER++P+ +W VA M R VGVA
Sbjct: 408 PMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAV 467
Query: 598 LNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDA 657
LN LY+VGG DG++ L+S E Y P N+W M M R G GV +YA GG+D
Sbjct: 468 LNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDG 527
Query: 658 PASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTM 717
L+ VERYD +T+TWT VAP+ R A+G+ + R+Y +GGYDG T+L+++
Sbjct: 528 QDQ------LNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSV 581
Query: 718 ESYDPQTNEWTQMASLNIGRAGACVVVIKQP 748
E YDP T+ W+++ + GR+G V V +P
Sbjct: 582 ECYDPDTDTWSEVTRMTSGRSGVGVAVTMEP 612
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 360 bits (923), Expect = 3e-99
Identities = 207/571 (36%), Positives = 306/571 (53%), Gaps = 23/571 (4%)
Query: 189 YQAVHHAEQTFRKMESYLKQQQLCDVILIVGNRKIPA-----HRLVLSSVSDYFAAMFTS 243
Y H +Q F M QQLCDV L V + PA H++VL+S S F AMFT+
Sbjct: 54 YTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTN 113
Query: 244 DVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCH 303
+ E E + +EGI P + L++FAYT + + E + +++ A + Q+ VV C
Sbjct: 114 GLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSD 173
Query: 304 FLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLA 363
FL++ L PSN +GI FA+ GC+EL + A Y + EV + +EF L +L L++
Sbjct: 174 FLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLIS 233
Query: 364 SDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQIL-ADLENHALFKN 422
DD+NV E +FHA + WVKYD + R + LL +R L P L L+ + ++
Sbjct: 234 RDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQS 293
Query: 423 DLECQKLILEAMKYHLLPERRTLMQSPRTKP-RKSTVGTLYAVGGMDNNKGATTIEKYDL 481
D C+ +++ E TL + + P R VG L G + + +E Y+
Sbjct: 294 DSRCKDYLVKIF------EELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNP 347
Query: 482 RTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGR----DGLKTLNTVECYNPKTKTWTVLP 537
W++ + R V+ L+ +GGR DG + ++CYNP T W+
Sbjct: 348 SDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCA 407
Query: 538 PMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAA 597
PMS R+ +GV V++G IYAVGG G + N+VER++P+ +W VA M R VGVA
Sbjct: 408 PMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAV 467
Query: 598 LNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDA 657
LN LY+VGG DG++ L+S E Y P N+W M M R G GV +YA GG+D
Sbjct: 468 LNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDG 527
Query: 658 PASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTM 717
L+ VERYD +T+TWT VAP+ R A+G+ + R+Y +GGYDG T+L+++
Sbjct: 528 QDQ------LNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSV 581
Query: 718 ESYDPQTNEWTQMASLNIGRAGACVVVIKQP 748
E YDP T+ W+++ + GR+G V V +P
Sbjct: 582 ECYDPDTDTWSEVTRMTSGRSGVGVAVTMEP 612
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 328 bits (841), Expect = 1e-89
Identities = 189/576 (32%), Positives = 308/576 (53%), Gaps = 22/576 (3%)
Query: 182 SSSSEEFYQAVHHAEQTFRKMESYLKQQ-----QLCDVILIVGNRKIPAHRLVLSSVSDY 236
+++S F+Q H E+ M + + +LCDV++ V + AH+ +L S S Y
Sbjct: 6 AAASTRFHQP--HMERKMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSY 63
Query: 237 FAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQ 296
F A+FTS +++ + GI P+ + ++++AYT + + D +E LLAAA +
Sbjct: 64 FRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMG 123
Query: 297 VVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIR-NQEFLLLPA 355
+V CC FL L NC+GI F D C EL + A+ + + N E+++ + EFL L
Sbjct: 124 IVRGCCEFLKSELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSV 183
Query: 356 EELHKLLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQ-ILADL 414
EL ++ D++NV E+ +F A++ W+ +D Q+R +S+LL +RL L+ + + ++
Sbjct: 184 TELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNV 243
Query: 415 ENHALFKNDLECQKLILEAMK----YHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNN 470
+ + K+ EC+ +I+ A+K ++ + +P T+PR L+A+GG
Sbjct: 244 KMNDYVKDSEECKPVIINALKAMYDLNMNGPSNSDFTNPLTRPRLP-YAILFAIGGWSGG 302
Query: 471 KGATTIEKYDLRTNLWIQAGMMN-GRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPK 529
IE YD R + W+ R G A + +++IGG D + N+V+ ++P
Sbjct: 303 SPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPV 362
Query: 530 TKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIA 589
KTW + PM + R + VTVL IYA+GG DG+ LNT ER++P++ QWT +A M
Sbjct: 363 KKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQ 422
Query: 590 RSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFL 649
RS L GK+Y GG +G+ CL + E Y+ +N+W + APM RR G+GV +
Sbjct: 423 RSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHV 482
Query: 650 YAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYD 709
YAVGG D + L E Y P +TW + + PR G+ ++ D L+ VGG++
Sbjct: 483 YAVGGFDG------ANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFN 536
Query: 710 GQTYLNTMESYDPQTNEWTQMASLNIGRAG-ACVVV 744
G T +E YD +T+EW ++I R+ +C VV
Sbjct: 537 GFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVV 572
Score = 98.2 bits (243), Expect = 2e-20
Identities = 53/148 (35%), Positives = 83/148 (56%), Gaps = 13/148 (8%)
Query: 602 LYSVGGRDGSSCLSSMEYYDPHTNKW-NMCAPMCKRRGGVGVATCDGFLYAVGGHDAPAS 660
L+++GG G S +++E YD ++W N+ R G A G++Y +GG D+
Sbjct: 293 LFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDS--- 349
Query: 661 NHCSRLLDY---VERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTM 717
+DY V+R+DP TW VAP+ R V V +LG+ +YA+GG+DG LNT
Sbjct: 350 ------VDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTA 403
Query: 718 ESYDPQTNEWTQMASLNIGRAGACVVVI 745
E Y+P+TN+WT +A ++ R+ A +
Sbjct: 404 ERYEPETNQWTLIAPMHEQRSDASATTL 431
Score = 91.7 bits (226), Expect = 2e-18
Identities = 47/156 (30%), Positives = 76/156 (48%), Gaps = 1/156 (0%)
Query: 446 MQSPRTKPRKSTV-GTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVI 504
M R+ +T+ G +Y GG + N+ T E Y+ +N W M RR GV
Sbjct: 419 MHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAY 478
Query: 505 DDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGW 564
+ ++ +GG DG L + E Y+P TW +P M R G+ V++ ++ VGG +G+
Sbjct: 479 GEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGF 538
Query: 565 SYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNG 600
+ VE +D ++ +W MSI RS + + G
Sbjct: 539 TTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVVPG 574
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 317 bits (812), Expect = 3e-86
Identities = 184/571 (32%), Positives = 298/571 (52%), Gaps = 24/571 (4%)
Query: 194 HAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEI 253
HA+ ++ Q CDV L VG AHRLVL++ S YFAA+FT + E+ ++ +
Sbjct: 19 HAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVV 78
Query: 254 KMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSN 313
+ GI+ L+ F YTG + + + ++ L+ AA +LQL +VV +CC FL + P N
Sbjct: 79 PILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLN 138
Query: 314 CLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEE 373
C+GI F++ C +L++ + +Y + +EV +EFL L ++L K+L S+++++ DE
Sbjct: 139 CIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEY 198
Query: 374 TIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQ-ILADLENHALFKNDLECQKLILE 432
+F A M W+ D+ R + +L IR PLLPPQ +L +E + F + Q L+ E
Sbjct: 199 QVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKE 258
Query: 433 AMKYHLLPERR---TLMQSPRTKPRKSTVGTLYAVGG--------MDNNKGATTIEKYDL 481
+ P+ + +Q+ + +PRK LYAVGG +++ + +E++D
Sbjct: 259 YCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDT 318
Query: 482 RTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMST 541
+ W ++ R GV V+ ++ IGG + ECY+P TK WT + M+
Sbjct: 319 FSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNH 378
Query: 542 HRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGK 601
R GLGV V G IYA+GG G NT+ER+DP +W V +M+++R G + G
Sbjct: 379 PRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGL 438
Query: 602 LYSVGGRDGSSC-LSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPAS 660
+Y +GG L S E YDP + +W+ PM RR +GVA + +Y+VGG
Sbjct: 439 IYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGW----- 493
Query: 661 NHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGG------YDGQTYL 714
N L VE+Y + + W VA + +PR + V + LY GG + L
Sbjct: 494 NETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTL 553
Query: 715 NTMESYDPQTNEWTQMASLNIGRAGACVVVI 745
+++E Y+P ++ WT++ ++ R V V+
Sbjct: 554 DSVEVYNPHSDTWTEIGNMITSRCEGGVAVL 584
>gi|223890235 intracisternal A particle-promoted polypeptide isoform
2 [Homo sapiens]
Length = 582
Score = 305 bits (781), Expect = 1e-82
Identities = 175/527 (33%), Positives = 277/527 (52%), Gaps = 18/527 (3%)
Query: 194 HAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEI 253
HA+ ++ Q CDV L VG AHRLVL++ S YFAA+FT + E+ ++ +
Sbjct: 19 HAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVV 78
Query: 254 KMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSN 313
+ GI+ L+ F YTG + + + ++ L+ AA +LQL +VV +CC FL + P N
Sbjct: 79 PILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLN 138
Query: 314 CLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEE 373
C+GI F++ C +L++ + +Y + +EV +EFL L ++L K+L S+++++ DE
Sbjct: 139 CIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEY 198
Query: 374 TIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQ-ILADLENHALFKNDLECQKLILE 432
+F A M W+ D+ R + +L IR PLLPPQ +L +E + F + Q L+ E
Sbjct: 199 QVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKE 258
Query: 433 AMKYHLLPERR---TLMQSPRTKPRKSTVGTLYAVGG--------MDNNKGATTIEKYDL 481
+ P+ + +Q+ + +PRK LYAVGG +++ + +E++D
Sbjct: 259 YCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDT 318
Query: 482 RTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMST 541
+ W ++ R GV V+ ++ IGG + ECY+P TK WT + M+
Sbjct: 319 FSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNH 378
Query: 542 HRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGK 601
R GLGV V G IYA+GG G NT+ER+DP +W V +M+++R G + G
Sbjct: 379 PRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGL 438
Query: 602 LYSVGGRDGSSC-LSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPAS 660
+Y +GG L S E YDP + +W+ PM RR +GVA + +Y+VGG
Sbjct: 439 IYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGW----- 493
Query: 661 NHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGG 707
N L VE+Y + + W VA + +PR + V + LY GG
Sbjct: 494 NETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG 540
Score = 109 bits (273), Expect = 8e-24
Identities = 68/178 (38%), Positives = 97/178 (54%), Gaps = 7/178 (3%)
Query: 459 GTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGG--RDG 516
G +YA+GG + TIE++D N W G M R FG + ++VIGG +G
Sbjct: 390 GAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEG 449
Query: 517 LKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGG-HDGWSYLNTVERWDP 575
++ L + E Y+P +K W+ LPPM T R LGV L IY+VGG ++ L+TVE++
Sbjct: 450 IE-LRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSF 508
Query: 576 QSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSS--CLSSMEYYDPHTNKW-NMC 630
+ ++W VASM + R+ + V A+NG LY GGR S Y+ KW NMC
Sbjct: 509 EEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPDTHRYEVFRLKWENMC 566
Score = 91.7 bits (226), Expect = 2e-18
Identities = 49/144 (34%), Positives = 74/144 (51%), Gaps = 14/144 (9%)
Query: 602 LYSVGGR--------DGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVG 653
LY+VGG S LS +E +D + W + + + R G+GV G +YA+G
Sbjct: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
Query: 654 GHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTY 713
G S + D E YDP T WT VA ++ PR +GVC+ +YA+GG+ G
Sbjct: 350 GEKD------SMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEI 403
Query: 714 LNTMESYDPQTNEWTQMASLNIGR 737
NT+E +DP N+W + ++ + R
Sbjct: 404 GNTIERFDPDENKWEVVGNMAVSR 427
Score = 73.2 bits (178), Expect = 8e-13
Identities = 40/99 (40%), Positives = 53/99 (53%), Gaps = 2/99 (2%)
Query: 648 FLYAVGGHDAPASNHCS--RLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAV 705
+LYAVGG+ S R L VER+D + WT V+ L R +GV +LG +YA+
Sbjct: 289 YLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAI 348
Query: 706 GGYDGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVV 744
GG + E YDP T +WT +AS+N R G V V
Sbjct: 349 GGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCV 387
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 267 bits (682), Expect = 3e-71
Identities = 177/599 (29%), Positives = 298/599 (49%), Gaps = 19/599 (3%)
Query: 166 RLSSTGHSMTPQSDLDSSSS--EEFYQAVHHAEQTFRKMESYLKQQQLCDVILIVGNRK- 222
+LS G M S L SS + + + H+ + + + LCDV L+ G+
Sbjct: 44 KLSLGGSEMGLSSHLQSSKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDD 103
Query: 223 -IPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDT 281
P HR++++S SDYF AMFT + E IK+ G+ L ++ F YT L L D
Sbjct: 104 AFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDN 163
Query: 282 IENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENI 341
+++ L AA LQ+ V++ C FL+ + NC+ + A+ E+ K +S+ ++N
Sbjct: 164 LQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNF 223
Query: 342 MEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFI 401
++ EFL LP E L +L+S+ + E +F A W++ + + R + + L+ I
Sbjct: 224 PALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLE-EPRMDFAAKLMKNI 282
Query: 402 RLPLLPPQILAD-LENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGT 460
R PL+ PQ L + ++ + D C L+LEA Y ++P + +MQS RT R T
Sbjct: 283 RFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTT-H 341
Query: 461 LYAVGGMDNNKGATT--IEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRD--- 515
L +GG+ + + + YD + + W M+ R Q G+AVI + L+V+GG+
Sbjct: 342 LVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYD 401
Query: 516 --GLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERW 573
G ++TV ++P+ W + ++ R ++ L+G +YAVGG + L TVE +
Sbjct: 402 TKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECY 461
Query: 574 DPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPM 633
+P++ +WT+VA MS G +Y GG + + +DP T+KW APM
Sbjct: 462 NPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPM 521
Query: 634 CKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAV 693
RG + T LY +GG+ ++ +L E Y P D WT +A + + V
Sbjct: 522 TTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLS-CEYYSPILDQWTPIAAMLRGQSDV 580
Query: 694 GVCLLGDRLYAVGGY--DGQTYLNTMESYDPQTNEWTQMASL--NIGRAGACVVVIKQP 748
GV + +++Y VGGY + + + ++ YDP +EW ++ L ++G AC + + P
Sbjct: 581 GVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPP 639
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 264 bits (674), Expect = 3e-70
Identities = 167/551 (30%), Positives = 274/551 (49%), Gaps = 18/551 (3%)
Query: 202 MESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPN 261
M + KQ+ LCDVIL+V RKIPAHR+VL++ S +F MFT+++ E+K E++++ +P+
Sbjct: 34 MNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPD 93
Query: 262 ALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFA 321
+ LV+FAYT + + + +++LL AA Q+ V ++C FL + + SNCLGI A
Sbjct: 94 IIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLA 153
Query: 322 DAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMM 381
+ C EL A + ++ EV + EFL L + + LL D + V E+ ++ A +
Sbjct: 154 ECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVR 213
Query: 382 WVKYDMQSRCNDLSMLLAFIRLPLLPPQILA-DLENHALFKNDLECQKLILEAMKYHLL- 439
W+KYD +R + +LA +R PL+ L+ ++ L +++ EC K+++ M+YHLL
Sbjct: 214 WLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLS 273
Query: 440 PERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQF 499
PE R + T+PR+ A+ G + D W +R
Sbjct: 274 PEDREELVD-GTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYS---WTDIRCPFEKRRDA 329
Query: 500 GVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVG 559
D+ ++++GG L + ++CYN +W T R L EG IY G
Sbjct: 330 ACVFWDNVVYILGGSQ-LFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSG 388
Query: 560 GHD-GWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSS----CL 614
G + G S L E +D +++ W SM R + G+ NG +Y GG G++ L
Sbjct: 389 GSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVL 448
Query: 615 SSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYD 674
+S E YDP T W PM + R G+ ++AVGG + LD VE YD
Sbjct: 449 NSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGG------LDNVEYYD 502
Query: 675 PKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASLN 734
K + W MV+P+ V +G +Y + G+ G L + Y+ +T++W + +
Sbjct: 503 IKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVR 562
Query: 735 IGRAGACVVVI 745
+C++ +
Sbjct: 563 AFPVTSCLICV 573
Score = 50.4 bits (119), Expect = 6e-06
Identities = 42/188 (22%), Positives = 71/188 (37%), Gaps = 10/188 (5%)
Query: 563 GWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDP 622
G S + ++P+ WT + R + +Y +GG + M+ Y+
Sbjct: 299 GGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFP-IKRMDCYNV 357
Query: 623 HTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTM 682
+ W R + +G +Y GG + S L E YD +T++W
Sbjct: 358 VKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNS-----ALYLFECYDTRTESWHT 412
Query: 683 VAPLSMPRDAVGVCLLGDRLYAVGGYDGQTY----LNTMESYDPQTNEWTQMASLNIGRA 738
+ R + G+ +Y GG G LN+ E YDP T WT++ + R
Sbjct: 413 KPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARK 472
Query: 739 GACVVVIK 746
+V +K
Sbjct: 473 NHGLVFVK 480
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 264 bits (674), Expect = 3e-70
Identities = 169/580 (29%), Positives = 290/580 (50%), Gaps = 17/580 (2%)
Query: 183 SSSEEFYQAVHHAEQTFRKMESYLKQQQLCDVILIVGNRK--IPAHRLVLSSVSDYFAAM 240
+ + F+ + H+ + + + LCDV L+ G+ P HR +++S SDYF AM
Sbjct: 21 AGTTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAM 80
Query: 241 FTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEV 300
FT + E IK+ G++ L ++ F YT L L D +++ L AA LQ+ V++
Sbjct: 81 FTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDF 140
Query: 301 CCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHK 360
C FL+ + NC+ + A+ IE+ K +++ ++N ++ EFL LP E L
Sbjct: 141 CKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAF 200
Query: 361 LLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILAD-LENHAL 419
+L+S+ + E +F A W++ + R + + L+ IR PL+ PQ L + ++
Sbjct: 201 VLSSNSLKHCTELELFKAACRWLRLE-DPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDF 259
Query: 420 FKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATT--IE 477
+ D C L+LEA Y ++P + +MQS RT R + L +GG+ + + +
Sbjct: 260 MRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDST-HLVTLGGVLRQQLVVSKELR 318
Query: 478 KYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRD-----GLKTLNTVECYNPKTKT 532
YD R W M+ R Q G+AVI + L+V+GG+ G ++TV ++P+
Sbjct: 319 MYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNK 378
Query: 533 WTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARST 592
W + ++ R ++ L+G +YAVGG L TVE ++P+ +W++VA MS
Sbjct: 379 WMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYG 438
Query: 593 VGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAV 652
G +Y GG + + + +DP T+KW APM RG + T LY +
Sbjct: 439 HAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVI 498
Query: 653 GGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGY--DG 710
GG+ ++ +L E Y P D WT +A + + VGV + +++Y VGGY +
Sbjct: 499 GGNHFRGTSDYDDVLS-CEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNN 557
Query: 711 QTYLNTMESYDPQTNEWTQMASL--NIGRAGACVVVIKQP 748
+ + ++ YDP+ +EW ++ L ++G AC + + P
Sbjct: 558 RCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPP 597
>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
Length = 564
Score = 259 bits (662), Expect = 6e-69
Identities = 164/545 (30%), Positives = 271/545 (49%), Gaps = 18/545 (3%)
Query: 208 QQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLV 267
++ LCDVIL+V RKIPAHR+VL++ S +F MFT+++ E+K E++++ +P+ + LV
Sbjct: 18 KKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLV 77
Query: 268 QFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCI 327
+FAYT + + + +++LL AA Q+ V ++C FL + + SNCLGI A+ C
Sbjct: 78 EFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCP 137
Query: 328 ELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDM 387
EL A + ++ EV + EFL L + + LL D + V E+ ++ A + W+KYD
Sbjct: 138 ELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDE 197
Query: 388 QSRCNDLSMLLAFIRLPLLPPQILA-DLENHALFKNDLECQKLILEAMKYHLL-PERRTL 445
+R + +LA +R PL+ L+ ++ L +++ EC K+++ M+YHLL PE R
Sbjct: 198 PNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREE 257
Query: 446 MQSPRTKPRKSTVGTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVID 505
+ T+PR+ A+ G + D W +R D
Sbjct: 258 LVD-GTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYS---WTDIRCPFEKRRDAACVFWD 313
Query: 506 DKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHD-GW 564
+ ++++GG L + ++CYN +W T R L EG IY GG + G
Sbjct: 314 NVVYILGGSQ-LFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGN 372
Query: 565 SYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSS----CLSSMEYY 620
S L E +D +++ W SM R + G+ NG +Y GG G++ L+S E Y
Sbjct: 373 SALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVY 432
Query: 621 DPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTW 680
DP T W PM + R G+ ++AVGG + LD VE YD K + W
Sbjct: 433 DPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGG------LDNVEYYDIKLNEW 486
Query: 681 TMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASLNIGRAGA 740
MV+P+ V +G +Y + G+ G L + Y+ +T++W + + +
Sbjct: 487 KMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVRAFPVTS 546
Query: 741 CVVVI 745
C++ +
Sbjct: 547 CLICV 551
Score = 50.4 bits (119), Expect = 6e-06
Identities = 42/188 (22%), Positives = 71/188 (37%), Gaps = 10/188 (5%)
Query: 563 GWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDP 622
G S + ++P+ WT + R + +Y +GG + M+ Y+
Sbjct: 277 GGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFP-IKRMDCYNV 335
Query: 623 HTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTM 682
+ W R + +G +Y GG + S L E YD +T++W
Sbjct: 336 VKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNS-----ALYLFECYDTRTESWHT 390
Query: 683 VAPLSMPRDAVGVCLLGDRLYAVGGYDGQTY----LNTMESYDPQTNEWTQMASLNIGRA 738
+ R + G+ +Y GG G LN+ E YDP T WT++ + R
Sbjct: 391 KPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARK 450
Query: 739 GACVVVIK 746
+V +K
Sbjct: 451 NHGLVFVK 458
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 256 bits (653), Expect = 7e-68
Identities = 172/568 (30%), Positives = 282/568 (49%), Gaps = 26/568 (4%)
Query: 174 MTPQSDLDSSSSEEFYQAVHHAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSV 233
M P+S L +F HAE + + + DVI+ V ++ P HR VLS+
Sbjct: 29 MDPKS-LTGHEFFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSAC 87
Query: 234 SDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQ 293
S YF AMF +D E+++ +++ GI A+ +Q+ YTG +++ + ++ L + L Q
Sbjct: 88 SSYFRAMFCNDHRESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQ 147
Query: 294 LPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLL 353
+ + + C FL + L P NCLGI+ FAD L ++ ++ +V +++EFL L
Sbjct: 148 ISVLRDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLEL 207
Query: 354 PAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQ-ILA 412
+EL + SD++ + EE +F A+M WV + R L LL +RLPLL P +
Sbjct: 208 DKDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQ 267
Query: 413 DLENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKST--VGTLYAVGGMDNN 470
+E L +N EC +L+ EA +YH+L M SPRT+PR+ST + VGG +
Sbjct: 268 TVEVDQLIQNSPECYQLLHEARRYHILGNE---MMSPRTRPRRSTGYSEVIVVVGGCERV 324
Query: 471 KGATT--IEKYDLRTNLWIQ-AGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYN 527
G E YD T W A + + ++ V + + + V GGR + V YN
Sbjct: 325 GGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINSR---DVWIYN 381
Query: 528 PKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMS 587
+ W + ++ R + VL G +Y VGG+DG + L++VE +D S +WT VA +
Sbjct: 382 SQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLK 441
Query: 588 IARSTVGVAALNGKLYSV-GGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCD 646
A S+ V + GKL+ + GG D ++C ++ YDP TN W + A + + + + +
Sbjct: 442 EAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLN 501
Query: 647 GFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVG 706
+Y GG L + YDP D W V ++ G+ + ++Y +G
Sbjct: 502 NLIYVAGG-----------LTKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILG 550
Query: 707 G-YDGQTYLNTMESYDPQTNEWTQMASL 733
G + +T+ YDP T+ T +A++
Sbjct: 551 GRRENGEATDTILCYDPATSIITGVAAM 578
Score = 76.6 bits (187), Expect = 8e-14
Identities = 69/237 (29%), Positives = 104/237 (43%), Gaps = 27/237 (11%)
Query: 521 NTVECYN--PKTKTWTVL-----PPMSTHRHGLG---VTVLEGPIYAVGGHDGWSYLNTV 570
N+ ECY + + + +L P + R G V V+ G VGG + L
Sbjct: 277 NSPECYQLLHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFN----LPYT 332
Query: 571 ERWDPQSQQWTFVASM-SIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNM 629
E +DP + +W +A + +S V AL + GGR S + Y+ N W
Sbjct: 333 ECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINSR---DVWIYNSQLNIWIR 389
Query: 630 CAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMP 689
A + K R +A G +Y VGG+D L VE YD ++ WT VAPL
Sbjct: 390 VASLNKGRWRHKMAVLLGKVYVVGGYDG------QNRLSSVECYDSFSNRWTEVAPLKEA 443
Query: 690 RDAVGVCLLGDRLYAVGGY-DGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVVI 745
+ V +L+ +GG D T + ++SYDP+TN W A++ I A C+ +
Sbjct: 444 VSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPI--AKRCITAV 498
>gi|24475847 influenza virus NS1A binding protein [Homo sapiens]
Length = 642
Score = 254 bits (648), Expect = 3e-67
Identities = 174/596 (29%), Positives = 287/596 (48%), Gaps = 53/596 (8%)
Query: 196 EQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKM 255
E + K+ + K Q CDV L V ++ AHR VL+ S Y +F SD +K
Sbjct: 16 ESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKF 75
Query: 256 EGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCL 315
+ ++P A+ L+ +AYT L+ ++ ++++ +AA L++ +V +VC +L+ + ++C+
Sbjct: 76 DDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCI 135
Query: 316 GIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETI 375
R FA G L+ +Y E+++++ +EFL LP +L +L D+V +P +
Sbjct: 136 SYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVML-EDNVCLPSNGKL 194
Query: 376 FHALMMWVKYDMQSRCNDLSMLLAFIRL------------PLLPPQ--ILADLENHALF- 420
+ ++ WV+ + + L L+ ++ LL Q + ++H F
Sbjct: 195 YTKVINWVQRSIWENGDSLEELMEEVQTLYYSADHKLLDGNLLDGQAEVFGSDDDHIQFV 254
Query: 421 --KNDLECQKLILEAMKYHLLPERRTLMQSPRTK-----PRKSTVGTLYAVGGMDN---- 469
K E + + L +QSP+ + K++ T + +D
Sbjct: 255 QKKPPRENGHKQISSSSTGCLSSPNATVQSPKHEWKIVASEKTSNNTYLCLAVLDGIFCV 314
Query: 470 ---------NKGATTIEK------YDLRTNLWIQAGM--MNGRRLQFGVAVIDDKLFVIG 512
T+ K ++++ + I+ M M R G A ++ KL G
Sbjct: 315 IFLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAG 374
Query: 513 GRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSY-LNTVE 571
G + + L TVECYNP T W+ L PM T R + VL G +Y VGG +G S L+ E
Sbjct: 375 GYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGE 434
Query: 572 RWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRD--GSSCLSSMEYYDPHTNKWNM 629
+D W V + R GV ALNGKLY VGG D G L + + +DP T W
Sbjct: 435 MYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTS 494
Query: 630 CAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMP 689
CAP+ RR V G+LY +GG + S +C L+ VERY+P+ +TWT++AP+++
Sbjct: 495 CAPLNIRRHQSAVCELGGYLYIIGGAE---SWNC---LNTVERYNPENNTWTLIAPMNVA 548
Query: 690 RDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVVI 745
R GV +L +L+ GG+DG ++ +E YDP NEW M ++ R+ A + +
Sbjct: 549 RRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATV 604
Score = 186 bits (472), Expect = 7e-47
Identities = 99/273 (36%), Positives = 149/273 (54%), Gaps = 9/273 (3%)
Query: 459 GTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLK 518
G L A GG + + T+E Y+ T+ W M R +F +AV+ +L+V+GG +G
Sbjct: 368 GKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHS 427
Query: 519 T-LNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHD--GWSYLNTVERWDP 575
L+ E Y+ W +P + T+R GV L G +Y VGG D G L + +DP
Sbjct: 428 DDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDP 487
Query: 576 QSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCK 635
++ WT A ++I R V L G LY +GG + +CL+++E Y+P N W + APM
Sbjct: 488 VTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNV 547
Query: 636 RRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGV 695
R G GVA +G L+ GG D + C VE YDP + W M+ ++ PR G+
Sbjct: 548 ARRGAGVAVLNGKLFVCGGFDGSHAISC------VEMYDPTRNEWKMMGNMTSPRSNAGI 601
Query: 696 CLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWT 728
+G+ +YAVGG+DG +LNT+E Y+ ++NEW+
Sbjct: 602 ATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWS 634
Score = 171 bits (434), Expect = 2e-42
Identities = 90/240 (37%), Positives = 135/240 (56%), Gaps = 10/240 (4%)
Query: 446 MQSPRTKPRKSTV-GTLYAVGGMDNNKGATTI-EKYDLRTNLWIQAGMMNGRRLQFGVAV 503
M++PR + + + + G LY VGG + + + E YD + WI + R GV
Sbjct: 401 MRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCA 460
Query: 504 IDDKLFVIGGRD--GLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGH 561
++ KL+++GG D G K L + ++P TK WT P++ RH V L G +Y +GG
Sbjct: 461 LNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGA 520
Query: 562 DGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYD 621
+ W+ LNTVER++P++ WT +A M++AR GVA LNGKL+ GG DGS +S +E YD
Sbjct: 521 ESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYD 580
Query: 622 PHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWT 681
P N+W M M R G+AT +YAVGG D + L+ VE Y+ +++ W+
Sbjct: 581 PTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDG------NEFLNTVEVYNLESNEWS 634
>gi|8922854 kelch-like 26 [Homo sapiens]
Length = 615
Score = 253 bits (647), Expect = 3e-67
Identities = 186/617 (30%), Positives = 299/617 (48%), Gaps = 36/617 (5%)
Query: 153 DNSSQATGEGCGHRLSSTGHSMTPQSDLDSSSSEEF-YQAVHHAEQTFRKMESYLKQQQL 211
++ + G G G + P S D + + + + A H+ + + + Q QL
Sbjct: 3 ESGGSSGGAGGGGAFGAGPGPERPNSTADKNGALKCTFSAPSHSTSLLQGLATLRAQGQL 62
Query: 212 CDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAY 271
DV+L + PAH++VL++ SDYF AMFT + EA Q+ I+++G+ L ++ FAY
Sbjct: 63 LDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREASQDVIELKGVSARGLRHIIDFAY 122
Query: 272 TGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMK 331
+ + L D ++++L AA LQ+ VVE+C FL + CL I A L +
Sbjct: 123 SAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMSVETCLNIGQMATTFSLASLRE 182
Query: 332 VAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQSRC 391
++T + +++ ++FL LP E L L S+ + E +F A + W+++D +R
Sbjct: 183 SVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQSCAEIDLFRAAVRWLQHD-PARR 241
Query: 392 NDLSMLLAFIRLPLLPPQILAD-LENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPR 450
S +L IR PL+ L D ++ + D+ C++ +LEA Y +LP R+ MQSPR
Sbjct: 242 PRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLCRQYLLEAFNYQVLPFRQHEMQSPR 301
Query: 451 TKPRKSTVGTLYAVGG---MDNNKGATTIEKYDLRTNLWIQAGMMNGRRL---QFG---- 500
T R S V +L GG D+++ ++ + Y L + G + R L + G
Sbjct: 302 TAVR-SDVPSLVTFGGTPYTDSDRSVSS-KVYQLP-----EPGARHFRELTEMEVGCSHT 354
Query: 501 -VAVIDDKLFVIGG-----RDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGP 554
VAV+D+ ++V GG R G ++ Y+P W L M R + VL G
Sbjct: 355 CVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQAMQESRIQFQLNVLCGM 414
Query: 555 IYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGS-SC 613
+YA GG + L +VER+ P+ +W + S+ AA G+LY GG S
Sbjct: 415 VYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAGAASGGRLYISGGYGISVED 474
Query: 614 LSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDY--VE 671
++ YDP ++W APM + R + G +YA+GG +H R D VE
Sbjct: 475 KKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGR----MDHVDRCFDVLAVE 530
Query: 672 RYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQ--TYLNTMESYDPQTNEWTQ 729
Y P+TD WT V+P+ + G CLL ++Y VGGY+ + ++ Y+ T+EW +
Sbjct: 531 YYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNWRLNNVTGIVQVYNTDTDEWER 590
Query: 730 MASLNIGRAG-ACVVVI 745
AG AC V+
Sbjct: 591 DLHFPESFAGIACAPVL 607
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 240 bits (613), Expect = 3e-63
Identities = 158/554 (28%), Positives = 265/554 (47%), Gaps = 39/554 (7%)
Query: 202 MESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPN 261
+E+ + L DVIL V ++ HR+VL++ S+YF AMF +D+ E ++ I ++G+D
Sbjct: 62 LETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAE 121
Query: 262 ALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFA 321
+ L+ + YT + + ++ +L AA L Q ++V+ C FL + L+P NC+GI A
Sbjct: 122 TMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLA 181
Query: 322 DAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMM 381
D L K SY ++N ++++ ++EFL LP + LH +L SDD+ V +E +F +M
Sbjct: 182 DTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMS 241
Query: 382 WVKYDMQSRCNDLSMLLAFIRLPLLPPQILAD-LENHALFKNDLECQKLILEAMKYHLLP 440
WV++ R L +L +RLPLL P + +E L + E L+ EA YHL
Sbjct: 242 WVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLSG 301
Query: 441 ERRTLMQSPRTKPRKSTVGT--LYAVGGMDNN--------------KGATTIEKYDLRTN 484
+ S RTKPR + +GG + + + K L +
Sbjct: 302 NE---IISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTEH 358
Query: 485 LWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRH 544
+ N + ++F + +++++ GG++ T + V YN W + ++ R
Sbjct: 359 ---ELESENKKWVEFACVTLKNEVYISGGKE---TQHDVWKYNSSINKWIQIEYLNIGRW 412
Query: 545 GLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYS 604
+ VL G +Y +GG DG +N VE +DP W+ A + + S+ + KLY
Sbjct: 413 RHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYV 472
Query: 605 V-GGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHC 663
+ GG +G + YDP TNKW++ A M + + +Y VGG
Sbjct: 473 IGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGG--------- 523
Query: 664 SRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQT-YLNTMESYDP 722
+ + Y P D+W +V LS R + G+ +RLY GG D + + T+ +DP
Sbjct: 524 --AMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDP 581
Query: 723 QTNEWTQMASLNIG 736
+ + T+ L G
Sbjct: 582 EAQKLTEECVLPRG 595
>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 875
Score = 233 bits (595), Expect = 4e-61
Identities = 163/572 (28%), Positives = 267/572 (46%), Gaps = 31/572 (5%)
Query: 194 HAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQE-- 251
H + +++ + + D+ ++V R+ H+ VL+S S YF + V ++ Q
Sbjct: 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGR 370
Query: 252 ---EIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKL 308
E+ + + + L L++F YTG L + + LL AA Q +VC FL K
Sbjct: 371 EKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQ 430
Query: 309 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVN 368
L SNCLG+ A A+A C EL +A ++ ++ EV +E L + ++ +++D +N
Sbjct: 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLN 490
Query: 369 VPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILAD-LENHALFKNDLECQ 427
EE ++ ++ W+K D +R + LLA +RLP + P L + ++N L K+ C+
Sbjct: 491 TKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACR 550
Query: 428 KLILEAMKYHLLPERRTLMQSPRTKPRKS--TVGTLYAVGGMD----NNKGATTIEKYDL 481
L+ EA +YH+LP R MQ+PRT+PR S + VGG + + ++
Sbjct: 551 DLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNP 610
Query: 482 RTNLWIQ-AGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMS 540
+ N W A + R F V D +++ GG + TL V CY W ++ M+
Sbjct: 611 QNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMT 670
Query: 541 THRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNG 600
R V +G IY +GG ++ VER+D + QW VA + A + G
Sbjct: 671 VPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGG 730
Query: 601 KLYSVGG-RDGSSCLSSMEYYDPHTNKWNMC-APMCKRRGGVGVATCDGFLYAVGGHDAP 658
K+Y GG + ++ Y P TN W+ +PM + V T +GF++ +GG A
Sbjct: 731 KIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAV-TLNGFVFILGGAYAR 789
Query: 659 ASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQ--TYLNT 716
A+ YDP+ ++ R +L ++YA GG L
Sbjct: 790 ATT----------IYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGN 839
Query: 717 MESYDPQTNEWTQMASL--NIGRAGACVVVIK 746
ME+Y+P TN WT + + + R G CVV+ K
Sbjct: 840 MEAYEPTTNTWTLLPHMPCPVFRHG-CVVIKK 870
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,009,497
Number of Sequences: 37866
Number of extensions: 1496088
Number of successful extensions: 9819
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 205
Number of HSP's successfully gapped in prelim test: 83
Number of HSP's that attempted gapping in prelim test: 7213
Number of HSP's gapped (non-prelim): 981
length of query: 748
length of database: 18,247,518
effective HSP length: 110
effective length of query: 638
effective length of database: 14,082,258
effective search space: 8984480604
effective search space used: 8984480604
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.