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Search of human proteins with 109389362
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|109389362 arylsulfatase J [Homo sapiens]
(599 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|109389362 arylsulfatase J [Homo sapiens] 1267 0.0
gi|59797060 arylsulfatase family, member I [Homo sapiens] 741 0.0
gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens] 550 e-156
gi|38569407 arylsulfatase B isoform 2 precursor [Homo sapiens] 454 e-127
gi|4503899 galactosamine (N-acetyl)-6-sulfate sulfatase precurso... 148 2e-35
gi|146229331 arylsulfatase A isoform a precursor [Homo sapiens] 133 5e-31
gi|146229329 arylsulfatase A isoform a precursor [Homo sapiens] 133 5e-31
gi|146229324 arylsulfatase A isoform a precursor [Homo sapiens] 133 5e-31
gi|6005990 arylsulfatase A isoform a precursor [Homo sapiens] 133 5e-31
gi|45430057 Arylsulfatase G [Homo sapiens] 126 6e-29
gi|157266309 arylsulfatase E precursor [Homo sapiens] 100 3e-21
gi|53831991 steryl-sulfatase precursor [Homo sapiens] 99 1e-20
gi|71852584 arylsulfatase D isoform a precursor [Homo sapiens] 94 3e-19
gi|71852586 arylsulfatase D isoform b precursor [Homo sapiens] 94 3e-19
gi|31742482 arylsulfatase F precursor [Homo sapiens] 94 4e-19
gi|58743319 arylsulfatase family, member H [Homo sapiens] 84 3e-16
gi|146229327 arylsulfatase A isoform b [Homo sapiens] 83 6e-16
gi|4504061 glucosamine (N-acetyl)-6-sulfatase precursor [Homo sa... 65 2e-10
gi|189571643 sulfatase 1 [Homo sapiens] 64 3e-10
gi|189571641 sulfatase 1 [Homo sapiens] 64 3e-10
gi|189571638 sulfatase 1 [Homo sapiens] 64 3e-10
gi|189571636 sulfatase 1 [Homo sapiens] 64 3e-10
gi|4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo sap... 62 2e-09
gi|240255483 sulfatase 2 isoform a precursor [Homo sapiens] 59 1e-08
gi|240255478 sulfatase 2 isoform b precursor [Homo sapiens] 59 1e-08
gi|29789100 sulfatase 2 isoform a precursor [Homo sapiens] 59 1e-08
gi|4557659 iduronate-2-sulfatase isoform a precursor [Homo sapiens] 57 5e-08
gi|5360208 iduronate-2-sulfatase isoform b precursor [Homo sapiens] 57 6e-08
gi|169217295 PREDICTED: similar to iduronate 2-sulfatase (Hunter... 45 2e-04
gi|39930577 arylsulfatase K [Homo sapiens] 45 2e-04
>gi|109389362 arylsulfatase J [Homo sapiens]
Length = 599
Score = 1267 bits (3279), Expect = 0.0
Identities = 599/599 (100%), Positives = 599/599 (100%)
Query: 1 MAPRGCAGHPPPPSPQACVCPGKMLAMGALAGFWILCLLTYGYLSWGQALEEEEEGALLA 60
MAPRGCAGHPPPPSPQACVCPGKMLAMGALAGFWILCLLTYGYLSWGQALEEEEEGALLA
Sbjct: 1 MAPRGCAGHPPPPSPQACVCPGKMLAMGALAGFWILCLLTYGYLSWGQALEEEEEGALLA 60
Query: 61 QAGEKLEPSTTSTSQPHLIFILADDQGFRDVGYHGSEIKTPTLDKLAAEGVKLENYYVQP 120
QAGEKLEPSTTSTSQPHLIFILADDQGFRDVGYHGSEIKTPTLDKLAAEGVKLENYYVQP
Sbjct: 61 QAGEKLEPSTTSTSQPHLIFILADDQGFRDVGYHGSEIKTPTLDKLAAEGVKLENYYVQP 120
Query: 121 ICTPSRSQFITGKYQIHTGLQHSIIRPTQPNCLPLDNATLPQKLKEVGYSTHMVGKWHLG 180
ICTPSRSQFITGKYQIHTGLQHSIIRPTQPNCLPLDNATLPQKLKEVGYSTHMVGKWHLG
Sbjct: 121 ICTPSRSQFITGKYQIHTGLQHSIIRPTQPNCLPLDNATLPQKLKEVGYSTHMVGKWHLG 180
Query: 181 FYRKECMPTRRGFDTFFGSLLGSGDYYTHYKCDSPGMCGYDLYENDNAAWDYDNGIYSTQ 240
FYRKECMPTRRGFDTFFGSLLGSGDYYTHYKCDSPGMCGYDLYENDNAAWDYDNGIYSTQ
Sbjct: 181 FYRKECMPTRRGFDTFFGSLLGSGDYYTHYKCDSPGMCGYDLYENDNAAWDYDNGIYSTQ 240
Query: 241 MYTQRVQQILASHNPTKPIFLYIAYQAVHSPLQAPGRYFEHYRSIININRRRYAAMLSCL 300
MYTQRVQQILASHNPTKPIFLYIAYQAVHSPLQAPGRYFEHYRSIININRRRYAAMLSCL
Sbjct: 241 MYTQRVQQILASHNPTKPIFLYIAYQAVHSPLQAPGRYFEHYRSIININRRRYAAMLSCL 300
Query: 301 DEAINNVTLALKTYGFYNNSIIIYSSDNGGQPTAGGSNWPLRGSKGTYWEGGIRAVGFVH 360
DEAINNVTLALKTYGFYNNSIIIYSSDNGGQPTAGGSNWPLRGSKGTYWEGGIRAVGFVH
Sbjct: 301 DEAINNVTLALKTYGFYNNSIIIYSSDNGGQPTAGGSNWPLRGSKGTYWEGGIRAVGFVH 360
Query: 361 SPLLKNKGTVCKELVHITDWYPTLISLAEGQIDEDIQLDGYDIWETISEGLRSPRVDILH 420
SPLLKNKGTVCKELVHITDWYPTLISLAEGQIDEDIQLDGYDIWETISEGLRSPRVDILH
Sbjct: 361 SPLLKNKGTVCKELVHITDWYPTLISLAEGQIDEDIQLDGYDIWETISEGLRSPRVDILH 420
Query: 421 NIDPIYTKAKNGSWAAGYGIWNTAIQSAIRVQHWKLLTGNPGYSDWVPPQSFSNLGPNRW 480
NIDPIYTKAKNGSWAAGYGIWNTAIQSAIRVQHWKLLTGNPGYSDWVPPQSFSNLGPNRW
Sbjct: 421 NIDPIYTKAKNGSWAAGYGIWNTAIQSAIRVQHWKLLTGNPGYSDWVPPQSFSNLGPNRW 480
Query: 481 HNERITLSTGKSVWLFNITADPYERVDLSNRYPGIVKKLLRRLSQFNKTAVPVRYPPKDP 540
HNERITLSTGKSVWLFNITADPYERVDLSNRYPGIVKKLLRRLSQFNKTAVPVRYPPKDP
Sbjct: 481 HNERITLSTGKSVWLFNITADPYERVDLSNRYPGIVKKLLRRLSQFNKTAVPVRYPPKDP 540
Query: 541 RSNPRLNGGVWGPWYKEETKKKKPSKNQAEKKQKKSKKKKKKQQKAVSGSTCHSGVTCG 599
RSNPRLNGGVWGPWYKEETKKKKPSKNQAEKKQKKSKKKKKKQQKAVSGSTCHSGVTCG
Sbjct: 541 RSNPRLNGGVWGPWYKEETKKKKPSKNQAEKKQKKSKKKKKKQQKAVSGSTCHSGVTCG 599
>gi|59797060 arylsulfatase family, member I [Homo sapiens]
Length = 569
Score = 741 bits (1913), Expect = 0.0
Identities = 339/555 (61%), Positives = 431/555 (77%), Gaps = 7/555 (1%)
Query: 27 MGALAGFWILCLLTYGYLSWGQALEE-EEEGALLAQAGEKLEPSTTSTSQPHLIFILADD 85
M L GF ++ LL++GYLSW A +G +AGE +PS PH+IFIL DD
Sbjct: 1 MHTLTGFSLVSLLSFGYLSWDWAKPSFVADGP--GEAGE--QPSAAPPQPPHIIFILTDD 56
Query: 86 QGFRDVGYHGSEIKTPTLDKLAAEGVKLENYYVQPICTPSRSQFITGKYQIHTGLQHSII 145
QG+ DVGYHGS+I+TPTLD+LAA+GVKLENYY+QPICTPSRSQ +TG+YQIHTGLQHSII
Sbjct: 57 QGYHDVGYHGSDIETPTLDRLAAKGVKLENYYIQPICTPSRSQLLTGRYQIHTGLQHSII 116
Query: 146 RPTQPNCLPLDNATLPQKLKEVGYSTHMVGKWHLGFYRKECMPTRRGFDTFFGSLLGSGD 205
RP QPNCLPLD TLPQKL+E GYSTHMVGKWHLGFYRKEC+PTRRGFDTF GSL G+ D
Sbjct: 117 RPQQPNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGFYRKECLPTRRGFDTFLGSLTGNVD 176
Query: 206 YYTHYKCDSPGMCGYDLYENDNAAWDYDNGIYSTQMYTQRVQQILASHNPTKPIFLYIAY 265
YYT+ CD PG+CG+DL+E +N AW +G YST +Y QR ILASH+P +P+FLY+A+
Sbjct: 177 YYTYDNCDGPGVCGFDLHEGENVAWGL-SGQYSTMLYAQRASHILASHSPQRPLFLYVAF 235
Query: 266 QAVHSPLQAPGRYFEHYRSIININRRRYAAMLSCLDEAINNVTLALKTYGFYNNSIIIYS 325
QAVH+PLQ+P Y YR++ N+ RR+YAAM++C+DEA+ N+T ALK YGFYNNS+II+S
Sbjct: 236 QAVHTPLQSPREYLYRYRTMGNVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFS 295
Query: 326 SDNGGQPTAGGSNWPLRGSKGTYWEGGIRAVGFVHSPLLKNKGTVCKELVHITDWYPTLI 385
SDNGGQ +GGSNWPLRG KGTYWEGG+R +GFVHSPLLK K + L+HITDWYPTL+
Sbjct: 296 SDNGGQTFSGGSNWPLRGRKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLV 355
Query: 386 SLAEGQIDEDIQLDGYDIWETISEGLRSPRVDILHNIDPIYTKAKNGSWAAGYGIWNTAI 445
LA G LDGYD+W ISEG SPR +ILHNIDP+Y A++GS G+GIWNTA+
Sbjct: 356 GLAGGTTSAADGLDGYDVWPAISEGRASPRTEILHNIDPLYNHAQHGSLEGGFGIWNTAV 415
Query: 446 QSAIRVQHWKLLTGNPGYSDWVPPQSFSNLGPNRWHNERITLSTGKSVWLFNITADPYER 505
Q+AIRV WKLLTG+PGY DW+PPQ+ + + W+ ER+ S ++VWLFNI+ADPYER
Sbjct: 416 QAAIRVGEWKLLTGDPGYGDWIPPQTLATFPGSWWNLERMA-SVRQAVWLFNISADPYER 474
Query: 506 VDLSNRYPGIVKKLLRRLSQFNKTAVPVRYPPKDPRSNPRLNGGVWGPWYKEETKKKKPS 565
DL+ + P +V+ LL RL+++N+TA+PVRYP ++PR++P NGG WGPW +E ++++
Sbjct: 475 EDLAGQRPDVVRTLLARLAEYNRTAIPVRYPAENPRAHPDFNGGAWGPWASDEEEEEEEG 534
Query: 566 KNQAEKKQKKSKKKK 580
+ ++ + ++ KK K
Sbjct: 535 RARSFSRGRRKKKCK 549
>gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens]
Length = 533
Score = 550 bits (1418), Expect = e-156
Identities = 284/572 (49%), Positives = 365/572 (63%), Gaps = 58/572 (10%)
Query: 1 MAPRGCAGHPPPPSPQACVCPGKMLAMGALAGFWILCLLTYGYLSWGQALEEEEEGALLA 60
M PRG A P P P+ + P + +L LL LLA
Sbjct: 1 MGPRGAASLPRGPGPRRLLLPVVLP---------LLLLL------------------LLA 33
Query: 61 QAGEKLEPSTTSTSQPHLIFILADDQGFRDVGYHGSEIKTPTLDKLAAEGVKLENYYVQP 120
G ++ PHL+F+LADD G+ DVG+HGS I+TP LD LAA GV L+NYY QP
Sbjct: 34 PPGS----GAGASRPPHLVFLLADDLGWNDVGFHGSRIRTPHLDALAAGGVLLDNYYTQP 89
Query: 121 ICTPSRSQFITGKYQIHTGLQHSIIRPTQPNCLPLDNATLPQKLKEVGYSTHMVGKWHLG 180
+CTPSRSQ +TG+YQI TGLQH II P QP+C+PLD LPQ LKE GY+THMVGKWHLG
Sbjct: 90 LCTPSRSQLLTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLG 149
Query: 181 FYRKECMPTRRGFDTFFGSLLGSGDYYTHYKCD-----SPGMCGYDLYENDNAAWDYDNG 235
YRKEC+PTRRGFDT+FG LLGS DYY+H +C + C D + + A Y N
Sbjct: 150 MYRKECLPTRRGFDTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKN- 208
Query: 236 IYSTQMYTQRVQQILASHNPTKPIFLYIAYQAVHSPLQAPGRYFEHYRSIININRRRYAA 295
+YST ++T+R ++ +H P KP+FLY+A Q+VH PLQ P Y + Y I + NR YA
Sbjct: 209 MYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHEPLQVPEEYLKPYDFIQDKNRHHYAG 268
Query: 296 MLSCLDEAINNVTLALKTYGFYNNSIIIYSSDNGGQPTAGGSNWPLRGSKGTYWEGGIRA 355
M+S +DEA+ NVT ALK+ G +NN++ I+S+DNGGQ AGG+NWPLRG K + WEGG+R
Sbjct: 269 MVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQTLAGGNNWPLRGRKWSLWEGGVRG 328
Query: 356 VGFVHSPLLKNKGTVCKELVHITDWYPTLISLAEGQIDEDIQLDGYDIWETISEGLRSPR 415
VGFV SPLLK KG +EL+HI+DW PTL+ LA G + LDG+D+W+TISEG SPR
Sbjct: 329 VGFVASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSPSPR 388
Query: 416 VDILHNIDPIY-----------TKAKNGSWAAGYGIWNTAIQSAIRVQHWKLLTGNPGYS 464
+++LHNIDP + AK+ S Y +NT++ +AIR +WKLLTG PG
Sbjct: 389 IELLHNIDPNFVDSSPCPRNSMAPAKDDSSLPEYSAFNTSVHAAIRHGNWKLLTGYPGCG 448
Query: 465 DWVPPQSFSNLGPNRWHNERITLS--TGKSVWLFNITADPYERVDLSNRYPGIVKKLLRR 522
W PP P++++ I S K++WLF+I DP ER DLS YP IV KLL R
Sbjct: 449 YWFPP-------PSQYNVSEIPSSDPPTKTLWLFDIDRDPEERHDLSREYPHIVTKLLSR 501
Query: 523 LSQFNKTAVPVRYPPKDPRSNPRLNGGVWGPW 554
L ++K +VPV +P +DPR +P+ GVWGPW
Sbjct: 502 LQFYHKHSVPVYFPAQDPRCDPKAT-GVWGPW 532
>gi|38569407 arylsulfatase B isoform 2 precursor [Homo sapiens]
Length = 413
Score = 454 bits (1168), Expect = e-127
Identities = 225/429 (52%), Positives = 285/429 (66%), Gaps = 37/429 (8%)
Query: 1 MAPRGCAGHPPPPSPQACVCPGKMLAMGALAGFWILCLLTYGYLSWGQALEEEEEGALLA 60
M PRG A P P P+ + P + +L LL LLA
Sbjct: 1 MGPRGAASLPRGPGPRRLLLPVVLP---------LLLLL------------------LLA 33
Query: 61 QAGEKLEPSTTSTSQPHLIFILADDQGFRDVGYHGSEIKTPTLDKLAAEGVKLENYYVQP 120
G ++ PHL+F+LADD G+ DVG+HGS I+TP LD LAA GV L+NYY QP
Sbjct: 34 PPGS----GAGASRPPHLVFLLADDLGWNDVGFHGSRIRTPHLDALAAGGVLLDNYYTQP 89
Query: 121 ICTPSRSQFITGKYQIHTGLQHSIIRPTQPNCLPLDNATLPQKLKEVGYSTHMVGKWHLG 180
+CTPSRSQ +TG+YQI TGLQH II P QP+C+PLD LPQ LKE GY+THMVGKWHLG
Sbjct: 90 LCTPSRSQLLTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLG 149
Query: 181 FYRKECMPTRRGFDTFFGSLLGSGDYYTHYKCD-----SPGMCGYDLYENDNAAWDYDNG 235
YRKEC+PTRRGFDT+FG LLGS DYY+H +C + C D + + A Y N
Sbjct: 150 MYRKECLPTRRGFDTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKN- 208
Query: 236 IYSTQMYTQRVQQILASHNPTKPIFLYIAYQAVHSPLQAPGRYFEHYRSIININRRRYAA 295
+YST ++T+R ++ +H P KP+FLY+A Q+VH PLQ P Y + Y I + NR YA
Sbjct: 209 MYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHEPLQVPEEYLKPYDFIQDKNRHHYAG 268
Query: 296 MLSCLDEAINNVTLALKTYGFYNNSIIIYSSDNGGQPTAGGSNWPLRGSKGTYWEGGIRA 355
M+S +DEA+ NVT ALK+ G +NN++ I+S+DNGGQ AGG+NWPLRG K + WEGG+R
Sbjct: 269 MVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQTLAGGNNWPLRGRKWSLWEGGVRG 328
Query: 356 VGFVHSPLLKNKGTVCKELVHITDWYPTLISLAEGQIDEDIQLDGYDIWETISEGLRSPR 415
VGFV SPLLK KG +EL+HI+DW PTL+ LA G + LDG+D+W+TISEG SPR
Sbjct: 329 VGFVASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSPSPR 388
Query: 416 VDILHNIDP 424
+++LHNIDP
Sbjct: 389 IELLHNIDP 397
>gi|4503899 galactosamine (N-acetyl)-6-sulfate sulfatase precursor
[Homo sapiens]
Length = 522
Score = 148 bits (373), Expect = 2e-35
Identities = 128/488 (26%), Positives = 208/488 (42%), Gaps = 64/488 (13%)
Query: 76 PHLIFILADDQGFRDVGYHGSEIK-TPTLDKLAAEGVKLENYY-VQPICTPSRSQFITGK 133
P+++ +L DD G+ D+G +G + TP LD++AAEG+ N+Y P+C+PSR+ +TG+
Sbjct: 31 PNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLTGR 90
Query: 134 YQIHTGLQ------HSIIRPTQ-PNCLPLDNATLPQKLKEVGYSTHMVGKWHLGFYRKEC 186
I G + P + +P LP+ LK+ GY + +VGKWHLG +R +
Sbjct: 91 LPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLG-HRPQF 149
Query: 187 MPTRRGFDTFFGSLLGSGDYYTHYKCDSPGMCGYDLYENDNAAWDYDNGIYS-------- 238
P + GFD +FGS ++ Y D+ +Y + W+ Y
Sbjct: 150 HPLKHGFDEWFGS---PNCHFGPY--DNKARPNIPVYRD----WEMVGRYYEEFPINLKT 200
Query: 239 -----TQMYTQRVQQILASHNPTKPIFLYIAYQAVHSPLQAPGRYFEHYRSIININRRRY 293
TQ+Y Q + P FLY A A H+P+ A + R RY
Sbjct: 201 GEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLG------TSQRGRY 254
Query: 294 AAMLSCLDEAINNVTLALKTYGFYNNSIIIYSSDNGGQ----PTAGGSNWPLRGSKGTYW 349
+ +D++I + L+ +N+ + ++SDNG P GGSN P K T +
Sbjct: 255 GDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTF 314
Query: 350 EGGIRAVGFVHSPLLKNKGTVCKELVHITDWYPTLISLAEGQIDEDIQLDGYDIWETISE 409
EGG+R P G V +L I D + T ++LA D +DG ++ T+ +
Sbjct: 315 EGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQ 374
Query: 410 GLRSPRVDILHNIDPIYTKAKNGSWAAGYGIWNTAIQSAIRVQHWKLLTGNPGYSDWVPP 469
G R + D + A G A + W + W+ D+ P
Sbjct: 375 GRLMDRPIFYYRGDTLMA-ATLGQHKAHFWTWTNS---------WENFRQG---IDFCPG 421
Query: 470 QSFSNLGPNRWHNERITLSTGKSVWLFNITADPYERVDL---SNRYPGIVKKLLRRLSQF 526
Q+ S + + + K +F++ DP ER L S Y + ++ + Q
Sbjct: 422 QNVSGVTTHNLEDHT------KLPLIFHLGRDPGERFPLSFASAEYQEALSRITSVVQQH 475
Query: 527 NKTAVPVR 534
+ VP +
Sbjct: 476 QEALVPAQ 483
>gi|146229331 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 133 bits (334), Expect = 5e-31
Identities = 126/470 (26%), Positives = 203/470 (43%), Gaps = 52/470 (11%)
Query: 76 PHLIFILADDQGFRDVGYHGSEIKT-PTLDKLAAEGVKLENYYVQ-PICTPSRSQFITGK 133
P+++ I ADD G+ D+G +G T P LD+LAA G++ ++YV +CTPSR+ +TG+
Sbjct: 21 PNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGR 80
Query: 134 YQIHTGLQHSIIRPTQPNCLPLDNATLPQKLKEVGYSTHMVGKWHLGFYRKEC-MPTRRG 192
+ G+ ++ P+ LPL+ T+ + L GY T M GKWHLG + +P +G
Sbjct: 81 LPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQG 140
Query: 193 FDTFFGSLL----GSGDYYTHYKCDSP--GMCGYDLYE-------NDNAAWDYDNGIYST 239
F F G G T + +P G C L + A + G+ +
Sbjct: 141 FHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEA- 199
Query: 240 QMYTQRVQQILA-SHNPTKPIFLYIAYQAVHSPLQAPGRYFEHYRSIININRRRYAAMLS 298
Y ++A + +P FLY A H P Q G+ F R + L
Sbjct: 200 -RYMAFAHDLMADAQRQDRPFFLYYASHHTHYP-QFSGQSFAE-----RSGRGPFGDSLM 252
Query: 299 CLDEAINNVTLALKTYGFYNNSIIIYSSDNGGQP---TAGGSNWPLRGSKGTYWEGGIRA 355
LD A+ + A+ G +++I+++DNG + + GG + LR KGT +EGG+R
Sbjct: 253 ELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVRE 312
Query: 356 VGFVHSPLLKNKGTVCKELVHITDWYPTLISLAEGQIDEDIQLDGYDIWETISEGLRSPR 415
P G V EL D PTL +LA + ++ LDG+D+ + +SPR
Sbjct: 313 PALAFWPGHIAPG-VTHELASSLDLLPTLAALAGAPL-PNVTLDGFDLSPLLLGTGKSPR 370
Query: 416 VDILHNIDPIYTKAKNGSWAAGYGIWNTAIQSAIRVQHWKLLTGNPGYSDWVPPQSFSNL 475
+ P Y G +A G + T +SD +
Sbjct: 371 QSLF--FYPSYPDEVRGVFAVRTGKYKA-----------HFFTQGSAHSDTTADPAC--- 414
Query: 476 GPNRWHNERITLSTGKSVWLFNITADPYERVDLSNRYPGIVKKLLRRLSQ 525
+ +L+ + L++++ DP E +L G ++L+ L Q
Sbjct: 415 ------HASSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQ 458
>gi|146229329 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 133 bits (334), Expect = 5e-31
Identities = 126/470 (26%), Positives = 203/470 (43%), Gaps = 52/470 (11%)
Query: 76 PHLIFILADDQGFRDVGYHGSEIKT-PTLDKLAAEGVKLENYYVQ-PICTPSRSQFITGK 133
P+++ I ADD G+ D+G +G T P LD+LAA G++ ++YV +CTPSR+ +TG+
Sbjct: 21 PNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGR 80
Query: 134 YQIHTGLQHSIIRPTQPNCLPLDNATLPQKLKEVGYSTHMVGKWHLGFYRKEC-MPTRRG 192
+ G+ ++ P+ LPL+ T+ + L GY T M GKWHLG + +P +G
Sbjct: 81 LPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQG 140
Query: 193 FDTFFGSLL----GSGDYYTHYKCDSP--GMCGYDLYE-------NDNAAWDYDNGIYST 239
F F G G T + +P G C L + A + G+ +
Sbjct: 141 FHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEA- 199
Query: 240 QMYTQRVQQILA-SHNPTKPIFLYIAYQAVHSPLQAPGRYFEHYRSIININRRRYAAMLS 298
Y ++A + +P FLY A H P Q G+ F R + L
Sbjct: 200 -RYMAFAHDLMADAQRQDRPFFLYYASHHTHYP-QFSGQSFAE-----RSGRGPFGDSLM 252
Query: 299 CLDEAINNVTLALKTYGFYNNSIIIYSSDNGGQP---TAGGSNWPLRGSKGTYWEGGIRA 355
LD A+ + A+ G +++I+++DNG + + GG + LR KGT +EGG+R
Sbjct: 253 ELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVRE 312
Query: 356 VGFVHSPLLKNKGTVCKELVHITDWYPTLISLAEGQIDEDIQLDGYDIWETISEGLRSPR 415
P G V EL D PTL +LA + ++ LDG+D+ + +SPR
Sbjct: 313 PALAFWPGHIAPG-VTHELASSLDLLPTLAALAGAPL-PNVTLDGFDLSPLLLGTGKSPR 370
Query: 416 VDILHNIDPIYTKAKNGSWAAGYGIWNTAIQSAIRVQHWKLLTGNPGYSDWVPPQSFSNL 475
+ P Y G +A G + T +SD +
Sbjct: 371 QSLF--FYPSYPDEVRGVFAVRTGKYKA-----------HFFTQGSAHSDTTADPAC--- 414
Query: 476 GPNRWHNERITLSTGKSVWLFNITADPYERVDLSNRYPGIVKKLLRRLSQ 525
+ +L+ + L++++ DP E +L G ++L+ L Q
Sbjct: 415 ------HASSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQ 458
>gi|146229324 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 133 bits (334), Expect = 5e-31
Identities = 126/470 (26%), Positives = 203/470 (43%), Gaps = 52/470 (11%)
Query: 76 PHLIFILADDQGFRDVGYHGSEIKT-PTLDKLAAEGVKLENYYVQ-PICTPSRSQFITGK 133
P+++ I ADD G+ D+G +G T P LD+LAA G++ ++YV +CTPSR+ +TG+
Sbjct: 21 PNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGR 80
Query: 134 YQIHTGLQHSIIRPTQPNCLPLDNATLPQKLKEVGYSTHMVGKWHLGFYRKEC-MPTRRG 192
+ G+ ++ P+ LPL+ T+ + L GY T M GKWHLG + +P +G
Sbjct: 81 LPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQG 140
Query: 193 FDTFFGSLL----GSGDYYTHYKCDSP--GMCGYDLYE-------NDNAAWDYDNGIYST 239
F F G G T + +P G C L + A + G+ +
Sbjct: 141 FHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEA- 199
Query: 240 QMYTQRVQQILA-SHNPTKPIFLYIAYQAVHSPLQAPGRYFEHYRSIININRRRYAAMLS 298
Y ++A + +P FLY A H P Q G+ F R + L
Sbjct: 200 -RYMAFAHDLMADAQRQDRPFFLYYASHHTHYP-QFSGQSFAE-----RSGRGPFGDSLM 252
Query: 299 CLDEAINNVTLALKTYGFYNNSIIIYSSDNGGQP---TAGGSNWPLRGSKGTYWEGGIRA 355
LD A+ + A+ G +++I+++DNG + + GG + LR KGT +EGG+R
Sbjct: 253 ELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVRE 312
Query: 356 VGFVHSPLLKNKGTVCKELVHITDWYPTLISLAEGQIDEDIQLDGYDIWETISEGLRSPR 415
P G V EL D PTL +LA + ++ LDG+D+ + +SPR
Sbjct: 313 PALAFWPGHIAPG-VTHELASSLDLLPTLAALAGAPL-PNVTLDGFDLSPLLLGTGKSPR 370
Query: 416 VDILHNIDPIYTKAKNGSWAAGYGIWNTAIQSAIRVQHWKLLTGNPGYSDWVPPQSFSNL 475
+ P Y G +A G + T +SD +
Sbjct: 371 QSLF--FYPSYPDEVRGVFAVRTGKYKA-----------HFFTQGSAHSDTTADPAC--- 414
Query: 476 GPNRWHNERITLSTGKSVWLFNITADPYERVDLSNRYPGIVKKLLRRLSQ 525
+ +L+ + L++++ DP E +L G ++L+ L Q
Sbjct: 415 ------HASSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQ 458
>gi|6005990 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 133 bits (334), Expect = 5e-31
Identities = 126/470 (26%), Positives = 203/470 (43%), Gaps = 52/470 (11%)
Query: 76 PHLIFILADDQGFRDVGYHGSEIKT-PTLDKLAAEGVKLENYYVQ-PICTPSRSQFITGK 133
P+++ I ADD G+ D+G +G T P LD+LAA G++ ++YV +CTPSR+ +TG+
Sbjct: 21 PNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGR 80
Query: 134 YQIHTGLQHSIIRPTQPNCLPLDNATLPQKLKEVGYSTHMVGKWHLGFYRKEC-MPTRRG 192
+ G+ ++ P+ LPL+ T+ + L GY T M GKWHLG + +P +G
Sbjct: 81 LPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQG 140
Query: 193 FDTFFGSLL----GSGDYYTHYKCDSP--GMCGYDLYE-------NDNAAWDYDNGIYST 239
F F G G T + +P G C L + A + G+ +
Sbjct: 141 FHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEA- 199
Query: 240 QMYTQRVQQILA-SHNPTKPIFLYIAYQAVHSPLQAPGRYFEHYRSIININRRRYAAMLS 298
Y ++A + +P FLY A H P Q G+ F R + L
Sbjct: 200 -RYMAFAHDLMADAQRQDRPFFLYYASHHTHYP-QFSGQSFAE-----RSGRGPFGDSLM 252
Query: 299 CLDEAINNVTLALKTYGFYNNSIIIYSSDNGGQP---TAGGSNWPLRGSKGTYWEGGIRA 355
LD A+ + A+ G +++I+++DNG + + GG + LR KGT +EGG+R
Sbjct: 253 ELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVRE 312
Query: 356 VGFVHSPLLKNKGTVCKELVHITDWYPTLISLAEGQIDEDIQLDGYDIWETISEGLRSPR 415
P G V EL D PTL +LA + ++ LDG+D+ + +SPR
Sbjct: 313 PALAFWPGHIAPG-VTHELASSLDLLPTLAALAGAPL-PNVTLDGFDLSPLLLGTGKSPR 370
Query: 416 VDILHNIDPIYTKAKNGSWAAGYGIWNTAIQSAIRVQHWKLLTGNPGYSDWVPPQSFSNL 475
+ P Y G +A G + T +SD +
Sbjct: 371 QSLF--FYPSYPDEVRGVFAVRTGKYKA-----------HFFTQGSAHSDTTADPAC--- 414
Query: 476 GPNRWHNERITLSTGKSVWLFNITADPYERVDLSNRYPGIVKKLLRRLSQ 525
+ +L+ + L++++ DP E +L G ++L+ L Q
Sbjct: 415 ------HASSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQ 458
>gi|45430057 Arylsulfatase G [Homo sapiens]
Length = 525
Score = 126 bits (316), Expect = 6e-29
Identities = 107/377 (28%), Positives = 169/377 (44%), Gaps = 52/377 (13%)
Query: 71 TSTSQPHLIFILADDQGFRDVGYHGSEIK-TPTLDKLAAEGVKLENYYVQP-ICTPSRSQ 128
T +P+ + ILADD G+ D+G + +E K T LDK+A+EG++ +++ C+PSR+
Sbjct: 31 TRGQKPNFVIILADDMGWGDLGANWAETKDTANLDKMASEGMRFVDFHAAASTCSPSRAS 90
Query: 129 FITGKYQIHTGLQHSIIRPTQPNCLPLDNATLPQKLKEVGYSTHMVGKWHLGFYRKECMP 188
+TG+ + G+ + T LPL+ TL + L++ GY T ++GKWHLG + P
Sbjct: 91 LLTGRLGLRNGVTRNFA-VTSVGGLPLNETTLAEVLQQAGYVTGIIGKWHLG-HHGSYHP 148
Query: 189 TRRGFDTFFG----SLLGSGDY--YTHYKC------DSPGM-----CGYD----LYENDN 227
RGFD +FG +G D Y H C D P C D LYEN N
Sbjct: 149 NFRGFDYYFGIPYSHDMGCTDTPGYNHPPCPACPQGDGPSRNLQRDCYTDVALPLYENLN 208
Query: 228 AAWDYDNGIYSTQMYTQRVQQILASHNPT-KPIFLYIAYQAVHSPL---QAPGRYFEHYR 283
N Q Y ++ Q + + + +P LY+A +H PL Q P
Sbjct: 209 IVEQPVNLSSLAQKYAEKATQFIQRASTSGRPFLLYVALAHMHVPLPVTQLPA------- 261
Query: 284 SIININRRRYAAMLSCLDEAINNVTLALKTYGFYNNSIIIYSSDNG---GQPTAGGSNWP 340
R Y A L +D + + + + N+ + ++ DNG + GS P
Sbjct: 262 --APRGRSLYGAGLWEMDSLVGQIKDKV-DHTVKENTFLWFTGDNGPWAQKCELAGSVGP 318
Query: 341 LRG----------SKGTYWEGGIRAVGFVHSPLLKNKGTVCKELVHITDWYPTLISLAEG 390
G +K T WEGG R + P L+ + D +PT+++LA+
Sbjct: 319 FTGFWQTRQGGSPAKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAQA 378
Query: 391 QIDEDIQLDGYDIWETI 407
+ + + DG D+ E +
Sbjct: 379 SLPQGRRFDGVDVSEVL 395
>gi|157266309 arylsulfatase E precursor [Homo sapiens]
Length = 589
Score = 100 bits (250), Expect = 3e-21
Identities = 58/149 (38%), Positives = 88/149 (59%), Gaps = 15/149 (10%)
Query: 69 STTSTSQPHLIFILADDQGFRDVGYHGSE-IKTPTLDKLAAEGVKLENYY-VQPICTPSR 126
S S S+P+++ ++ADD G D+G +G+ ++TP +D+LA +GVKL + +CTPSR
Sbjct: 31 SDISASRPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSR 90
Query: 127 SQFITGKYQIHTGLQHSI-IRPTQ----PNCLPLDNATLPQKLKEVGYSTHMVGKWHLGF 181
+ F+TG+Y + +G+ SI R Q LP + T + LKE GY+T ++GKWHLG
Sbjct: 91 AAFLTGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKILKEKGYATGLIGKWHLGL 150
Query: 182 YRKECM-----PTRRGFDTFFG---SLLG 202
+ P GFD F+G SL+G
Sbjct: 151 NCESASDHCHHPLHHGFDHFYGMPFSLMG 179
Score = 68.6 bits (166), Expect = 2e-11
Identities = 78/336 (23%), Positives = 133/336 (39%), Gaps = 56/336 (16%)
Query: 238 STQMYTQRVQQILASHNPTKPIFLYIAYQAVHSPLQAPGRYFEHYRSIININRRRYAAML 297
+T + Q V L N P L++++ VH PL + +S+ + Y +
Sbjct: 271 TTPLILQEVASFL-KRNKHGPFLLFVSFLHVHIPLITMENFLG--KSLHGL----YGDNV 323
Query: 298 SCLDEAINNVTLALKTYGFYNNSIIIYSSDNGGQ-------PTAGGSNWPLRGSKGTY-W 349
+D + + L G N+++I ++SD+GG GG N +G KG W
Sbjct: 324 EEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNGIYKGGKGMGGW 383
Query: 350 EGGIRAVGFVHSPLLKNKGTVCKELVHITDWYPTLISLAEGQIDEDIQLDGYDIWE-TIS 408
EGGIR G P + G V E + D +PT++ LA G++ +D +DG D+ +
Sbjct: 384 EGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLLPLLLG 443
Query: 409 EGLRSPRVDILHNIDPIYTKAKNGSWAAGYGIWNTAIQSAIRVQHWKLLTGNPGYSDWVP 468
S ++H + A+ W+ + + WK+ P
Sbjct: 444 TAQHSDHEFLMHYCERFLHAAR----------WHQRDRGTM----WKVHFVTP------- 482
Query: 469 PQSFSNLGPNRWHNERITLSTGKSV------WLFNITADPYERVDLSNRYPGIVKKLLRR 522
F G + ++ G+ V LF+++ DP E L+ + +++ R
Sbjct: 483 --VFQPEGAGACYGRKVCPCFGEKVVHHDPPLLFDLSRDPSETHILTPASEPVFYQVMER 540
Query: 523 LSQ----FNKTAVPVRYPPKDPRSNPRLNGGVWGPW 554
+ Q +T PV P RL G +W PW
Sbjct: 541 VQQAVWEHQRTLSPV------PLQLDRL-GNIWRPW 569
>gi|53831991 steryl-sulfatase precursor [Homo sapiens]
Length = 583
Score = 98.6 bits (244), Expect = 1e-20
Identities = 54/144 (37%), Positives = 84/144 (58%), Gaps = 12/144 (8%)
Query: 67 EPSTTSTSQPHLIFILADDQGFRDVGYHGSE-IKTPTLDKLAAEGVKLENYYV-QPICTP 124
E + + S+P++I ++ADD G D G +G++ I+TP +D+LA+ GVKL + P+CTP
Sbjct: 18 EAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTP 77
Query: 125 SRSQFITGKYQIHTGLQH-----SIIRPTQPNCLPLDNATLPQKLKEVGYSTHMVGKWHL 179
SR+ F+TG+Y + +G+ + LP D T + LK+ GYST ++GKWHL
Sbjct: 78 SRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHL 137
Query: 180 GF--YRKECM---PTRRGFDTFFG 198
G + K P GF+ F+G
Sbjct: 138 GMSCHSKTDFCHHPLHHGFNYFYG 161
Score = 64.3 bits (155), Expect = 3e-10
Identities = 81/351 (23%), Positives = 130/351 (37%), Gaps = 59/351 (16%)
Query: 223 YENDNAAWDYDNGIYSTQMYTQRVQQILASHNPTKPIFLYIAYQAVHSPLQAPGRYFEHY 282
YE YDN TQ T Q + + T P L ++Y VH+ L + +
Sbjct: 248 YEIIQQPMSYDN---LTQRLTVEAAQFIQRNTET-PFLLVLSYLHVHTALFSSKDFAGKS 303
Query: 283 RSIININRRRYAAMLSCLDEAINNVTLALKTYGFYNNSIIIYSSDNGGQPTA-------- 334
+ + Y + +D ++ + L N+++I ++SD G
Sbjct: 304 QHGV------YGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIH 357
Query: 335 GGSNWPLRGSKGTYWEGGIRAVGFVHSPLLKNKGTVCKELVHITDWYPTLISLAEGQIDE 394
GGSN +G K WEGGIR G + P + G E D +PT+ LA + E
Sbjct: 358 GGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPE 417
Query: 395 DIQLDGYDIWETI-SEGLRSPRVDILHNIDPIYTKAKNGSWAAGYGIWNTAIQSAIRVQH 453
D +DG D+ + + RS + H + + W+ ++I
Sbjct: 418 DRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVR----------WHPQNSTSI---- 463
Query: 454 WKLLTGNPGYSDWVPPQSFSNLGPNRWHNERITLSTGKSV------WLFNITADPYERVD 507
WK P +F+ +G N + G V LF+I+ DP ER
Sbjct: 464 WKAFFFTP---------NFNPVGSNGCFATHVCFCFGSYVTHHDPPLLFDISKDPRERNP 514
Query: 508 LS----NRYPGIVKKLLRRLSQFNKTAVPVRYPPKDPRSNPRLNGGVWGPW 554
L+ R+ I+K + + +T P+ P N +W PW
Sbjct: 515 LTPASEPRFYEILKVMQEAADRHTQTL------PEVP-DQFSWNNFLWKPW 558
>gi|71852584 arylsulfatase D isoform a precursor [Homo sapiens]
Length = 593
Score = 94.4 bits (233), Expect = 3e-19
Identities = 54/144 (37%), Positives = 84/144 (58%), Gaps = 12/144 (8%)
Query: 67 EPSTTSTSQPHLIFILADDQGFRDVGYHGSE-IKTPTLDKLAAEGVKLENYYVQ-PICTP 124
EP T + +P+++ I+ADD G D+G +G+ ++TP +D+LA EGV+L + P+CTP
Sbjct: 32 EPKTANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGVRLTQHLAAAPLCTP 91
Query: 125 SRSQFITGKYQIHTGLQHSI-IRPTQPNC----LPLDNATLPQKLKEVGYSTHMVGKWHL 179
SR+ F+TG++ +G+ S R Q N LP + T + L++ GY+T ++GKWH
Sbjct: 92 SRAAFLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETTFARILQQHGYATGLIGKWHQ 151
Query: 180 GF----YRKEC-MPTRRGFDTFFG 198
G C P GFD F+G
Sbjct: 152 GVNCASRGDHCHHPLNHGFDYFYG 175
Score = 65.9 bits (159), Expect = 1e-10
Identities = 74/316 (23%), Positives = 125/316 (39%), Gaps = 55/316 (17%)
Query: 258 PIFLYIAYQAVHSPLQAPGRYFEHYRSIININRRRYAAMLSCLDEAINNVTLALKTYGFY 317
P L+++ VH PL + + + Y + +D I V A++ G
Sbjct: 293 PFLLFLSLLHVHIPLVTTSAFLGKSQHGL------YGDNVEEMDWLIGKVLNAIEDNGLK 346
Query: 318 NNSIIIYSSDNGGQPTA-------GGSNWPLRGSKGTY-WEGGIRAVGFVHSPLLKNKGT 369
N++ ++SD+GG A GG N +G KG WEGGIR G H P + G
Sbjct: 347 NSTFTYFTSDHGGHLEARDGHSQLGGWNGIYKGGKGMGGWEGGIRVPGIFHWPGVLPAGR 406
Query: 370 VCKELVHITDWYPTLISLAEGQIDEDIQLDGYDIWETISEG-LRSPRVDILHNIDPIYTK 428
V E + D +PT++ L G++ +D +DG+ + + RS + H
Sbjct: 407 VIGEPTSLMDVFPTVVQLVGGEVPQDRVIDGHSLVPLLQGAEARSAHEFLFHYCGQHLHA 466
Query: 429 AKNGSWAAGYGIWNTAIQSAIRVQHWKLLTGNPGYSDWVPPQSFSNLGPNRWHNERITLS 488
A+ W+ ++ WK+ + PQ F G + +
Sbjct: 467 AR----------WHQKDSGSV----WKV--------HYTTPQ-FHPEGAGACYGRGVCPC 503
Query: 489 TGKSV------WLFNITADPYE----RVDLSNRYPGIVKKLLRRLSQFNKTAVPVRYPPK 538
+G+ V LF+++ DP E D Y ++ ++ +S+ +T PV P +
Sbjct: 504 SGEGVTHHRPPLLFDLSRDPSEARPLTPDSEPLYHAVIARVGAAVSEHRQTLSPV--PQQ 561
Query: 539 DPRSNPRLNGGVWGPW 554
SN +W PW
Sbjct: 562 FSMSNI-----LWKPW 572
>gi|71852586 arylsulfatase D isoform b precursor [Homo sapiens]
Length = 382
Score = 94.4 bits (233), Expect = 3e-19
Identities = 54/144 (37%), Positives = 84/144 (58%), Gaps = 12/144 (8%)
Query: 67 EPSTTSTSQPHLIFILADDQGFRDVGYHGSE-IKTPTLDKLAAEGVKLENYYVQ-PICTP 124
EP T + +P+++ I+ADD G D+G +G+ ++TP +D+LA EGV+L + P+CTP
Sbjct: 32 EPKTANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGVRLTQHLAAAPLCTP 91
Query: 125 SRSQFITGKYQIHTGLQHSI-IRPTQPNC----LPLDNATLPQKLKEVGYSTHMVGKWHL 179
SR+ F+TG++ +G+ S R Q N LP + T + L++ GY+T ++GKWH
Sbjct: 92 SRAAFLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETTFARILQQHGYATGLIGKWHQ 151
Query: 180 GF----YRKEC-MPTRRGFDTFFG 198
G C P GFD F+G
Sbjct: 152 GVNCASRGDHCHHPLNHGFDYFYG 175
>gi|31742482 arylsulfatase F precursor [Homo sapiens]
Length = 590
Score = 94.0 bits (232), Expect = 4e-19
Identities = 53/136 (38%), Positives = 81/136 (59%), Gaps = 12/136 (8%)
Query: 75 QPHLIFILADDQGFRDVGYHGSE-IKTPTLDKLAAEGVKLENYY-VQPICTPSRSQFITG 132
+P+++ I+ DD G D+G +G++ ++TP +D+LA EGV+L + +C+PSRS F+TG
Sbjct: 29 KPNIVLIMVDDLGIGDLGCYGNDTMRTPHIDRLAREGVRLTQHISAASLCSPSRSAFLTG 88
Query: 133 KYQIHTGLQHS-----IIRPTQPNCLPLDNATLPQKLKEVGYSTHMVGKWHLGF----YR 183
+Y I +G+ S I P LPL+ TL LK+ GYST ++GKWH G
Sbjct: 89 RYPIRSGMVSSGNRRVIQNLAVPAGLPLNETTLAALLKKQGYSTGLIGKWHQGLNCDSRS 148
Query: 184 KEC-MPTRRGFDTFFG 198
+C P GFD ++G
Sbjct: 149 DQCHHPYNYGFDYYYG 164
Score = 73.6 bits (179), Expect = 5e-13
Identities = 72/289 (24%), Positives = 119/289 (41%), Gaps = 37/289 (12%)
Query: 261 LYIAYQAVHSPLQAPGRYFEHYRSIININRRRYAAMLSCLDEAINNVTLALKTYGFYNNS 320
L+ ++ VH+PL + + + Y + +D + + A+ +G NN+
Sbjct: 285 LFFSFLHVHTPLPTTDDFTGTSKHGL------YGDNVEEMDSMVGKILDAIDDFGLRNNT 338
Query: 321 IIIYSSDNGGQPTA-------GGSNWPLRGSKGTY-WEGGIRAVGFVHSPLLKNKGTVCK 372
++ ++SD+GG A GG N +G KG WEGGIR G V P G + K
Sbjct: 339 LVYFTSDHGGHLEARRGHAQLGGWNGIYKGGKGMGGWEGGIRVPGIVRWPGKVPAGRLIK 398
Query: 373 ELVHITDWYPTLISLAEGQIDEDIQLDGYDIWETISEGLRSPRVDILHNIDPIYTKAKNG 432
E + D PT+ S++ G + +D +DG D+ + +R + L + Y A
Sbjct: 399 EPTSLMDILPTVASVSGGSLPQDRVIDGRDLMPLLQGNVRHSEHEFLFHYCGSYLHAVR- 457
Query: 433 SWAAGYGIWNTAIQSAIRVQHWKLLTGNPGYSDWVPPQSFSNLGPN--RWHNERITLSTG 490
W S WK P + PP S + R E++T
Sbjct: 458 --------WIPKDDSG---SVWKAHYVTPVFQ---PPASGGCYVTSLCRCFGEQVTYH-- 501
Query: 491 KSVWLFNITADPYERVDLSNR----YPGIVKKLLRRLSQFNKTAVPVRY 535
LF+++ DP E L+ + ++KK+ L + +T VPV Y
Sbjct: 502 NPPLLFDLSRDPSESTPLTPATEPLHDFVIKKVANALKEHQETIVPVTY 550
>gi|58743319 arylsulfatase family, member H [Homo sapiens]
Length = 562
Score = 84.3 bits (207), Expect = 3e-16
Identities = 49/145 (33%), Positives = 77/145 (53%), Gaps = 13/145 (8%)
Query: 71 TSTSQPHLIFILADDQGFRDVGYHGSE-IKTPTLDKLAAEGVKLENYYVQP-ICTPSRSQ 128
T ++P+++ ++ADD G D+ +G+ + TP +D+LA+EGV+L + +CTPSR+
Sbjct: 2 TRNARPNIVLLMADDLGVGDLCCYGNNSVSTPNIDRLASEGVRLTQHLAAASMCTPSRAA 61
Query: 129 FITGKYQIHTG------LQHSIIRPTQPNCLPLDNATLPQKLKEVGYSTHMVGKWHLGF- 181
F+TG+Y I +G L + LP + T + L+ GY T ++GKWHLG
Sbjct: 62 FLTGRYPIRSGMVSAYNLNRAFTWLGGSGGLPTNETTFAKLLQHRGYRTGLIGKWHLGLS 121
Query: 182 ---YRKECM-PTRRGFDTFFGSLLG 202
C P GF F+G G
Sbjct: 122 CASRNDHCYHPLNHGFHYFYGVPFG 146
Score = 68.6 bits (166), Expect = 2e-11
Identities = 70/315 (22%), Positives = 125/315 (39%), Gaps = 52/315 (16%)
Query: 257 KPIFLYIAYQAVHSPLQAPGRYFEHYRSIININRRRYAAMLSCLDEAINNVTLALKTYGF 316
+P L+ ++ VH+PL + ++ + RY + +D + + AL
Sbjct: 259 EPFLLFFSFLHVHTPLISKKKFVGRSKY------GRYGDNVEEMDWMVGKILDALDQERL 312
Query: 317 YNNSIIIYSSDNGGQ-------PTAGGSNWPLRGSKGTY-WEGGIRAVGFVHSPLLKNKG 368
N++++ ++SDNGG GG N +G KG WEGGIR G P + G
Sbjct: 313 ANHTLVYFTSDNGGHLEPLDGAVQLGGWNGIYKGGKGMGGWEGGIRVPGIFRWPSVLEAG 372
Query: 369 TVCKELVHITDWYPTLISLAEGQIDEDIQLDGYDIWETISEGLRSPRVDILHNIDPIYTK 428
V E + D YPTL + G + +D +DG ++ + + L + +Y
Sbjct: 373 RVINEPTSLMDIYPTLSYIGGGILSQDRVIDGQNLMPLLEGRASHSDHEFLFHYCGVYLH 432
Query: 429 AKNGSWAAGYGIWNTAIQSAIRVQHWKLLTGNPGYSDWVPPQSFSNLGPNRWHNERITLS 488
W+ + + WK + +V P+ + G + I
Sbjct: 433 TVR---------WHQKDCATV----WK--------AHYVTPKFYPE-GTGACYGSGICSC 470
Query: 489 TGKSVW-----LFNITADPYERVDLS----NRYPGIVKKLLRRLSQFNKTAVPVRYPPKD 539
+G + LF+I+ DP E + L+ + ++KK+ + + +T PV
Sbjct: 471 SGDVTYHDPPLLFDISRDPSEALPLNPDNEPLFDSVIKKMEAAIREHRRTLTPV------ 524
Query: 540 PRSNPRLNGGVWGPW 554
P+ N +W PW
Sbjct: 525 PQQFSVFN-TIWKPW 538
>gi|146229327 arylsulfatase A isoform b [Homo sapiens]
Length = 423
Score = 83.2 bits (204), Expect = 6e-16
Identities = 100/405 (24%), Positives = 161/405 (39%), Gaps = 50/405 (12%)
Query: 139 GLQHSIIRPTQPNCLPLDNATLPQKLKEVGYSTHMVGKWHLGFYRKEC-MPTRRGFDTFF 197
G+ ++ P+ LPL+ T+ + L GY T M GKWHLG + +P +GF F
Sbjct: 2 GMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRFL 61
Query: 198 GSLL----GSGDYYTHYKCDSP--GMCGYDLYE-------NDNAAWDYDNGIYSTQMYTQ 244
G G T + +P G C L + A + G+ + Y
Sbjct: 62 GIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEAR--YMA 119
Query: 245 RVQQILA-SHNPTKPIFLYIAYQAVHSPLQAPGRYFEHYRSIININRRRYAAMLSCLDEA 303
++A + +P FLY A H P Q G+ F R + L LD A
Sbjct: 120 FAHDLMADAQRQDRPFFLYYASHHTHYP-QFSGQSFAE-----RSGRGPFGDSLMELDAA 173
Query: 304 INNVTLALKTYGFYNNSIIIYSSDNGGQP---TAGGSNWPLRGSKGTYWEGGIRAVGFVH 360
+ + A+ G +++I+++DNG + + GG + LR KGT +EGG+R
Sbjct: 174 VGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAF 233
Query: 361 SPLLKNKGTVCKELVHITDWYPTLISLAEGQIDEDIQLDGYDIWETISEGLRSPRVDILH 420
P G V EL D PTL +LA + ++ LDG+D+ + +SPR +
Sbjct: 234 WPGHIAPG-VTHELASSLDLLPTLAALAGAPL-PNVTLDGFDLSPLLLGTGKSPRQSLF- 290
Query: 421 NIDPIYTKAKNGSWAAGYGIWNTAIQSAIRVQHWKLLTGNPGYSDWVPPQSFSNLGPNRW 480
P Y G +A G + T +SD +
Sbjct: 291 -FYPSYPDEVRGVFAVRTGKYKA-----------HFFTQGSAHSDTTADPAC-------- 330
Query: 481 HNERITLSTGKSVWLFNITADPYERVDLSNRYPGIVKKLLRRLSQ 525
+ +L+ + L++++ DP E +L G ++L+ L Q
Sbjct: 331 -HASSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQ 374
>gi|4504061 glucosamine (N-acetyl)-6-sulfatase precursor [Homo
sapiens]
Length = 552
Score = 64.7 bits (156), Expect = 2e-10
Identities = 119/542 (21%), Positives = 207/542 (38%), Gaps = 119/542 (21%)
Query: 73 TSQPHLIFILADDQGFRDVGYHGSEIKTPTLDKLAAEGVKLENYYV-QPICTPSRSQFIT 131
T +P+++ +L DDQ D G T + G+ + YV +C PSR+ +T
Sbjct: 44 TRRPNVVLLLTDDQ---DEVLGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILT 100
Query: 132 GKYQIHTGLQHSIIRPTQPNCLP------LDNATLPQKLKEV-GYSTHMVGKWHLGFYRK 184
GKY + H + + NC + T P L+ + GY T GK + +
Sbjct: 101 GKYPHN---HHVVNNTLEGNCSSKSWQKIQEPNTFPAILRSMCGYQTFFAGK----YLNE 153
Query: 185 ECMPTRRGFD------TFFGSLLGSGDYYTHYKCDSPGMCGYDLYENDNAAWDYDNGIYS 238
P G + +++ +L + YY + + + G +N + D Y
Sbjct: 154 YGAPDAGGLEHVPLGWSYWYALEKNSKYYNY----TLSINGKARKHGENYSVD-----YL 204
Query: 239 TQMYTQRVQQILASHNPTKPIFLYIAYQAVHSPLQAPGRYFEHYRSII------------ 286
T + L + +P F+ IA A HSP A +Y + ++++
Sbjct: 205 TDVLANVSLDFLDYKSNFEPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPRNKNFNIHGT 264
Query: 287 ----------------------NINRRRYAAMLSCLDEAINNVTLALKTYGFYNNSIIIY 324
N R+R+ +LS +D+ + + L+ G NN+ I Y
Sbjct: 265 NKHWLIRQAKTPMTNSSIQFLDNAFRKRWQTLLS-VDDLVEKLVKRLEFTGELNNTYIFY 323
Query: 325 SSDNGGQPTAGGSNWPLRGSKGTYWEGGIRAVGFVHSPLLKNKGTVCKELVHITDWYPTL 384
+SDNG G + P+ K +E I+ V P +K T K LV D PT+
Sbjct: 324 TSDNGYH--TGQFSLPI--DKRQLYEFDIKVPLLVRGPGIKPNQT-SKMLVANIDLGPTI 378
Query: 385 ISLAEGQIDEDIQLDGYDIWETISEGLRSPRVDILHNIDPIYTKAKNGSWAAGYGIWNTA 444
+ +A GYD+ +T +G+ ++ PI A N +W + +
Sbjct: 379 LDIA-----------GYDLNKTQMDGM---------SLLPILRGASNLTWRSDVLVEYQG 418
Query: 445 IQSAIRVQHWKLLTGNPGYSDWVPPQSFSNLGPNRWHNERITLSTGKSVW---------- 494
V + +PG S P + + ++N + T ++W
Sbjct: 419 --EGRNVTDPTCPSLSPGVSQCFP----DCVCEDAYNNTYACVRTMSALWNLQYCEFDDQ 472
Query: 495 -----LFNITADPYERVDLSNRY-PGIVKKLLRRLSQFNKTAVPVRYPPK--DP--RSNP 544
++N+TADP + +++ P ++ K+ RL + P P DP R +P
Sbjct: 473 EVFVEVYNLTADPDQITNIAKTIDPELLGKMNYRLMMLQSCSGPTCRTPGVFDPGYRFDP 532
Query: 545 RL 546
RL
Sbjct: 533 RL 534
>gi|189571643 sulfatase 1 [Homo sapiens]
Length = 871
Score = 64.3 bits (155), Expect = 3e-10
Identities = 79/366 (21%), Positives = 146/366 (39%), Gaps = 59/366 (16%)
Query: 75 QPHLIFILADDQGFRDVGYHGSEIKTPTLDKLAAEGVKLENYYVQ-PICTPSRSQFITGK 133
+P++I +L DDQ DV ++ T + G N +V P+C PSRS +TGK
Sbjct: 42 RPNIILVLTDDQ---DVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGK 98
Query: 134 YQIHTGLQHSIIRPTQPNCLPL-DNATLPQKLKEVGYSTHMVGKWHLGFYRKECMPTRRG 192
Y + + + + P+ + + T L GY T GK+ L Y +P G
Sbjct: 99 YVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKY-LNEYNGSYIPP--G 155
Query: 193 FDTFFGSLLGSGDYYTHYKCDSPGMCGYDLYENDNAAWDYDNGIYSTQMYTQRVQQILAS 252
+ + G L+ + +Y + C + G+ + +DY ++ + + + S
Sbjct: 156 WREWLG-LIKNSRFYNYTVCRN-GI-------KEKHGFDYAKDYFTDLITNESINYFKMS 206
Query: 253 HN--PTKPIFLYIAYQAVHSP---------------------------------LQAPGR 277
P +P+ + I++ A H P +Q G
Sbjct: 207 KRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYNYAPNMDKHWIMQYTGP 266
Query: 278 YFEHYRSIININRRRYAAMLSCLDEAINNVTLALKTYGFYNNSIIIYSSDNGGQPTAGGS 337
+ NI +R+ L +D+++ + L G N+ IIY++D+G G
Sbjct: 267 MLPIHMEFTNILQRKRLQTLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHIGQFG- 325
Query: 338 NWPLRGSKGTYWEGGIRAVGFVHSPLLKNKGTVCKELVHITDWYPTLISLAEGQIDEDIQ 397
L K ++ IR F+ P ++ G++ ++V D PT++ +A +D
Sbjct: 326 ---LVKGKSMPYDFDIRVPFFIRGPSVE-PGSIVPQIVLNIDLAPTILDIA--GLDTPPD 379
Query: 398 LDGYDI 403
+DG +
Sbjct: 380 VDGKSV 385
>gi|189571641 sulfatase 1 [Homo sapiens]
Length = 871
Score = 64.3 bits (155), Expect = 3e-10
Identities = 79/366 (21%), Positives = 146/366 (39%), Gaps = 59/366 (16%)
Query: 75 QPHLIFILADDQGFRDVGYHGSEIKTPTLDKLAAEGVKLENYYVQ-PICTPSRSQFITGK 133
+P++I +L DDQ DV ++ T + G N +V P+C PSRS +TGK
Sbjct: 42 RPNIILVLTDDQ---DVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGK 98
Query: 134 YQIHTGLQHSIIRPTQPNCLPL-DNATLPQKLKEVGYSTHMVGKWHLGFYRKECMPTRRG 192
Y + + + + P+ + + T L GY T GK+ L Y +P G
Sbjct: 99 YVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKY-LNEYNGSYIPP--G 155
Query: 193 FDTFFGSLLGSGDYYTHYKCDSPGMCGYDLYENDNAAWDYDNGIYSTQMYTQRVQQILAS 252
+ + G L+ + +Y + C + G+ + +DY ++ + + + S
Sbjct: 156 WREWLG-LIKNSRFYNYTVCRN-GI-------KEKHGFDYAKDYFTDLITNESINYFKMS 206
Query: 253 HN--PTKPIFLYIAYQAVHSP---------------------------------LQAPGR 277
P +P+ + I++ A H P +Q G
Sbjct: 207 KRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYNYAPNMDKHWIMQYTGP 266
Query: 278 YFEHYRSIININRRRYAAMLSCLDEAINNVTLALKTYGFYNNSIIIYSSDNGGQPTAGGS 337
+ NI +R+ L +D+++ + L G N+ IIY++D+G G
Sbjct: 267 MLPIHMEFTNILQRKRLQTLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHIGQFG- 325
Query: 338 NWPLRGSKGTYWEGGIRAVGFVHSPLLKNKGTVCKELVHITDWYPTLISLAEGQIDEDIQ 397
L K ++ IR F+ P ++ G++ ++V D PT++ +A +D
Sbjct: 326 ---LVKGKSMPYDFDIRVPFFIRGPSVE-PGSIVPQIVLNIDLAPTILDIA--GLDTPPD 379
Query: 398 LDGYDI 403
+DG +
Sbjct: 380 VDGKSV 385
>gi|189571638 sulfatase 1 [Homo sapiens]
Length = 871
Score = 64.3 bits (155), Expect = 3e-10
Identities = 79/366 (21%), Positives = 146/366 (39%), Gaps = 59/366 (16%)
Query: 75 QPHLIFILADDQGFRDVGYHGSEIKTPTLDKLAAEGVKLENYYVQ-PICTPSRSQFITGK 133
+P++I +L DDQ DV ++ T + G N +V P+C PSRS +TGK
Sbjct: 42 RPNIILVLTDDQ---DVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGK 98
Query: 134 YQIHTGLQHSIIRPTQPNCLPL-DNATLPQKLKEVGYSTHMVGKWHLGFYRKECMPTRRG 192
Y + + + + P+ + + T L GY T GK+ L Y +P G
Sbjct: 99 YVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKY-LNEYNGSYIPP--G 155
Query: 193 FDTFFGSLLGSGDYYTHYKCDSPGMCGYDLYENDNAAWDYDNGIYSTQMYTQRVQQILAS 252
+ + G L+ + +Y + C + G+ + +DY ++ + + + S
Sbjct: 156 WREWLG-LIKNSRFYNYTVCRN-GI-------KEKHGFDYAKDYFTDLITNESINYFKMS 206
Query: 253 HN--PTKPIFLYIAYQAVHSP---------------------------------LQAPGR 277
P +P+ + I++ A H P +Q G
Sbjct: 207 KRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYNYAPNMDKHWIMQYTGP 266
Query: 278 YFEHYRSIININRRRYAAMLSCLDEAINNVTLALKTYGFYNNSIIIYSSDNGGQPTAGGS 337
+ NI +R+ L +D+++ + L G N+ IIY++D+G G
Sbjct: 267 MLPIHMEFTNILQRKRLQTLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHIGQFG- 325
Query: 338 NWPLRGSKGTYWEGGIRAVGFVHSPLLKNKGTVCKELVHITDWYPTLISLAEGQIDEDIQ 397
L K ++ IR F+ P ++ G++ ++V D PT++ +A +D
Sbjct: 326 ---LVKGKSMPYDFDIRVPFFIRGPSVE-PGSIVPQIVLNIDLAPTILDIA--GLDTPPD 379
Query: 398 LDGYDI 403
+DG +
Sbjct: 380 VDGKSV 385
>gi|189571636 sulfatase 1 [Homo sapiens]
Length = 871
Score = 64.3 bits (155), Expect = 3e-10
Identities = 79/366 (21%), Positives = 146/366 (39%), Gaps = 59/366 (16%)
Query: 75 QPHLIFILADDQGFRDVGYHGSEIKTPTLDKLAAEGVKLENYYVQ-PICTPSRSQFITGK 133
+P++I +L DDQ DV ++ T + G N +V P+C PSRS +TGK
Sbjct: 42 RPNIILVLTDDQ---DVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGK 98
Query: 134 YQIHTGLQHSIIRPTQPNCLPL-DNATLPQKLKEVGYSTHMVGKWHLGFYRKECMPTRRG 192
Y + + + + P+ + + T L GY T GK+ L Y +P G
Sbjct: 99 YVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKY-LNEYNGSYIPP--G 155
Query: 193 FDTFFGSLLGSGDYYTHYKCDSPGMCGYDLYENDNAAWDYDNGIYSTQMYTQRVQQILAS 252
+ + G L+ + +Y + C + G+ + +DY ++ + + + S
Sbjct: 156 WREWLG-LIKNSRFYNYTVCRN-GI-------KEKHGFDYAKDYFTDLITNESINYFKMS 206
Query: 253 HN--PTKPIFLYIAYQAVHSP---------------------------------LQAPGR 277
P +P+ + I++ A H P +Q G
Sbjct: 207 KRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYNYAPNMDKHWIMQYTGP 266
Query: 278 YFEHYRSIININRRRYAAMLSCLDEAINNVTLALKTYGFYNNSIIIYSSDNGGQPTAGGS 337
+ NI +R+ L +D+++ + L G N+ IIY++D+G G
Sbjct: 267 MLPIHMEFTNILQRKRLQTLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHIGQFG- 325
Query: 338 NWPLRGSKGTYWEGGIRAVGFVHSPLLKNKGTVCKELVHITDWYPTLISLAEGQIDEDIQ 397
L K ++ IR F+ P ++ G++ ++V D PT++ +A +D
Sbjct: 326 ---LVKGKSMPYDFDIRVPFFIRGPSVE-PGSIVPQIVLNIDLAPTILDIA--GLDTPPD 379
Query: 398 LDGYDI 403
+DG +
Sbjct: 380 VDGKSV 385
>gi|4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo
sapiens]
Length = 502
Score = 61.6 bits (148), Expect = 2e-09
Identities = 73/329 (22%), Positives = 115/329 (34%), Gaps = 53/329 (16%)
Query: 79 IFILADDQGFRDVGYHGSEIKTPTLDKLAAEGVKLENYYVQ-PICTPSRSQFITGKYQIH 137
+ +LADD GF Y+ S I TP LD LA + N + C+PSR+ +TG Q
Sbjct: 26 LLLLADDGGFESGAYNNSAIATPHLDALARRSLLFRNAFTSVSSCSPSRASLLTGLPQHQ 85
Query: 138 TGLQHSIIRPTQPNCLPLDNA-TLPQKLKEVGYSTHMVGKWHLGFYRKECMPTRRGFDTF 196
G+ + + D +LP L + G T ++GK H+G + P +
Sbjct: 86 NGMYG--LHQDVHHFNSFDKVRSLPLLLSQAGVRTGIIGKKHVG--PETVYPFDFAYTEE 141
Query: 197 FGSLLGSGDYYTHYKC--------------------DSPGMCGYDLYENDNAAWDYDNGI 236
GS+L G T K P CG+ + + NG
Sbjct: 142 NGSVLQVGRNITRIKLLVRKFLQTQDDRPFFLYVAFHDPHRCGHSQPQYGTFCEKFGNGE 201
Query: 237 YSTQMYTQRVQQILASHNPTKPIFLYIAYQAVHSPLQAPGRYFEHYRSIININRRRYAAM 296
Q + PL YF +
Sbjct: 202 SGMGRIPDWTPQ-------------------AYDPLDVLVPYFVPNTPAARADLAAQYTT 242
Query: 297 LSCLDEAINNVTLALKTYGFYNNSIIIYSSDNGGQPTAGGSNWPLRGSKGTYWEGGIRAV 356
+ +D+ + V L+ G N++++I++SDNG +G +N YW G +
Sbjct: 243 VGRMDQGVGLVLQELRDAGVLNDTLVIFTSDNGIPFPSGRTN--------LYWPGTAEPL 294
Query: 357 GFVHSPLLKNKGTVCKELVHITDWYPTLI 385
K G V + V + D PT++
Sbjct: 295 LVSSPEHPKRWGQVSEAYVSLLDLTPTIL 323
>gi|240255483 sulfatase 2 isoform a precursor [Homo sapiens]
Length = 870
Score = 58.9 bits (141), Expect = 1e-08
Identities = 86/373 (23%), Positives = 144/373 (38%), Gaps = 73/373 (19%)
Query: 75 QPHLIFILADDQGFRDVGYHGSEIKTPTLDKLAAEGVKLENYYVQ-PICTPSRSQFITGK 133
+P++I +L DDQ DV ++ T + G N +V P+C PSRS +TGK
Sbjct: 43 RPNIILVLTDDQ---DVELGSMQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTGK 99
Query: 134 YQIHTGLQHSIIRPTQPNC------LPLDNATLPQKLKEVGYSTHMVGKWHLGFYRKECM 187
Y +H ++ NC ++ T L GY T GK+ L Y +
Sbjct: 100 Y-VHNHNTYT----NNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKY-LNEYNGSYV 153
Query: 188 PTRRGFDTFFGSLLGSGDY-YTHYKCDSPGMCGYDLYENDNAAWDYDNGIYSTQMYTQRV 246
P G+ + G L S Y YT +C + E + + D Y T + T
Sbjct: 154 PP--GWKEWVGLLKNSRFYNYT--------LCRNGVKEKHGSDYSKD---YLTDLITNDS 200
Query: 247 QQILASHN---PTKPIFLYIAYQAVHSPLQAPGRYF-------EH--------------- 281
+ P +P+ + I++ A H P + +Y +H
Sbjct: 201 VSFFRTSKKMYPHRPVLMVISHAAPHGPEDSAPQYSRLFPNASQHITPSYNYAPNPDKHW 260
Query: 282 -----------YRSIININRRRYAAMLSCLDEAINNVTLALKTYGFYNNSIIIYSSDNGG 330
+ N+ +R+ L +D+++ + L G +N+ I+Y++D+G
Sbjct: 261 IMRYTGPMKPIHMEFTNMLQRKRLQTLMSVDDSMETIYNMLVETGELDNTYIVYTADHGY 320
Query: 331 QPTAGGSNWPLRGSKGTYWEGGIRAVGFVHSPLLKNKGTVCKELVHITDWYPTLISLAEG 390
G L K +E IR +V P ++ G + +V D PT++ +A
Sbjct: 321 HIGQFG----LVKGKSMPYEFDIRVPFYVRGPNVE-AGCLNPHIVLNIDLAPTILDIAGL 375
Query: 391 QIDEDIQLDGYDI 403
I D +DG I
Sbjct: 376 DIPAD--MDGKSI 386
>gi|240255478 sulfatase 2 isoform b precursor [Homo sapiens]
Length = 867
Score = 58.9 bits (141), Expect = 1e-08
Identities = 86/373 (23%), Positives = 144/373 (38%), Gaps = 73/373 (19%)
Query: 75 QPHLIFILADDQGFRDVGYHGSEIKTPTLDKLAAEGVKLENYYVQ-PICTPSRSQFITGK 133
+P++I +L DDQ DV ++ T + G N +V P+C PSRS +TGK
Sbjct: 43 RPNIILVLTDDQ---DVELGSMQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTGK 99
Query: 134 YQIHTGLQHSIIRPTQPNC------LPLDNATLPQKLKEVGYSTHMVGKWHLGFYRKECM 187
Y +H ++ NC ++ T L GY T GK+ L Y +
Sbjct: 100 Y-VHNHNTYT----NNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKY-LNEYNGSYV 153
Query: 188 PTRRGFDTFFGSLLGSGDY-YTHYKCDSPGMCGYDLYENDNAAWDYDNGIYSTQMYTQRV 246
P G+ + G L S Y YT +C + E + + D Y T + T
Sbjct: 154 PP--GWKEWVGLLKNSRFYNYT--------LCRNGVKEKHGSDYSKD---YLTDLITNDS 200
Query: 247 QQILASHN---PTKPIFLYIAYQAVHSPLQAPGRYF-------EH--------------- 281
+ P +P+ + I++ A H P + +Y +H
Sbjct: 201 VSFFRTSKKMYPHRPVLMVISHAAPHGPEDSAPQYSRLFPNASQHITPSYNYAPNPDKHW 260
Query: 282 -----------YRSIININRRRYAAMLSCLDEAINNVTLALKTYGFYNNSIIIYSSDNGG 330
+ N+ +R+ L +D+++ + L G +N+ I+Y++D+G
Sbjct: 261 IMRYTGPMKPIHMEFTNMLQRKRLQTLMSVDDSMETIYNMLVETGELDNTYIVYTADHGY 320
Query: 331 QPTAGGSNWPLRGSKGTYWEGGIRAVGFVHSPLLKNKGTVCKELVHITDWYPTLISLAEG 390
G L K +E IR +V P ++ G + +V D PT++ +A
Sbjct: 321 HIGQFG----LVKGKSMPYEFDIRVPFYVRGPNVE-AGCLNPHIVLNIDLAPTILDIAGL 375
Query: 391 QIDEDIQLDGYDI 403
I D +DG I
Sbjct: 376 DIPAD--MDGKSI 386
>gi|29789100 sulfatase 2 isoform a precursor [Homo sapiens]
Length = 870
Score = 58.9 bits (141), Expect = 1e-08
Identities = 86/373 (23%), Positives = 144/373 (38%), Gaps = 73/373 (19%)
Query: 75 QPHLIFILADDQGFRDVGYHGSEIKTPTLDKLAAEGVKLENYYVQ-PICTPSRSQFITGK 133
+P++I +L DDQ DV ++ T + G N +V P+C PSRS +TGK
Sbjct: 43 RPNIILVLTDDQ---DVELGSMQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTGK 99
Query: 134 YQIHTGLQHSIIRPTQPNC------LPLDNATLPQKLKEVGYSTHMVGKWHLGFYRKECM 187
Y +H ++ NC ++ T L GY T GK+ L Y +
Sbjct: 100 Y-VHNHNTYT----NNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKY-LNEYNGSYV 153
Query: 188 PTRRGFDTFFGSLLGSGDY-YTHYKCDSPGMCGYDLYENDNAAWDYDNGIYSTQMYTQRV 246
P G+ + G L S Y YT +C + E + + D Y T + T
Sbjct: 154 PP--GWKEWVGLLKNSRFYNYT--------LCRNGVKEKHGSDYSKD---YLTDLITNDS 200
Query: 247 QQILASHN---PTKPIFLYIAYQAVHSPLQAPGRYF-------EH--------------- 281
+ P +P+ + I++ A H P + +Y +H
Sbjct: 201 VSFFRTSKKMYPHRPVLMVISHAAPHGPEDSAPQYSRLFPNASQHITPSYNYAPNPDKHW 260
Query: 282 -----------YRSIININRRRYAAMLSCLDEAINNVTLALKTYGFYNNSIIIYSSDNGG 330
+ N+ +R+ L +D+++ + L G +N+ I+Y++D+G
Sbjct: 261 IMRYTGPMKPIHMEFTNMLQRKRLQTLMSVDDSMETIYNMLVETGELDNTYIVYTADHGY 320
Query: 331 QPTAGGSNWPLRGSKGTYWEGGIRAVGFVHSPLLKNKGTVCKELVHITDWYPTLISLAEG 390
G L K +E IR +V P ++ G + +V D PT++ +A
Sbjct: 321 HIGQFG----LVKGKSMPYEFDIRVPFYVRGPNVE-AGCLNPHIVLNIDLAPTILDIAGL 375
Query: 391 QIDEDIQLDGYDI 403
I D +DG I
Sbjct: 376 DIPAD--MDGKSI 386
>gi|4557659 iduronate-2-sulfatase isoform a precursor [Homo sapiens]
Length = 550
Score = 57.0 bits (136), Expect = 5e-08
Identities = 91/405 (22%), Positives = 151/405 (37%), Gaps = 97/405 (23%)
Query: 69 STTSTSQPHLIFILADDQGFRDVGYHGSE-IKTPTLDKLAAEGVKLENYYVQP-ICTPSR 126
+ ++T +++ I+ DD +G +G + +++P +D+LA+ + +N + Q +C PSR
Sbjct: 30 ANSTTDALNVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSR 88
Query: 127 SQFITGKYQIHTGLQ--HSIIRPTQPNCLPLDNATLPQKLKEVGYSTHMVGK-WHLGF-- 181
F+TG+ T L +S R N +T+PQ KE GY T VGK +H G
Sbjct: 89 VSFLTGRRPDTTRLYDFNSYWRVHAGNF-----STIPQYFKENGYVTMSVGKVFHPGISS 143
Query: 182 YRKECMPTRRGFDTFFGSLLGSGDYYTHYKCDSPG-------MCGYDLYENDNAAWDYDN 234
+ P F + S S Y C P +C D+ D
Sbjct: 144 NHTDDSPYSWSFPPYHPS---SEKYENTKTCRGPDGELHANLLCPVDVL-------DVPE 193
Query: 235 GIYSTQMYTQRVQQILAS-HNPTKPIFLYIAYQAVHSPLQAPGRYFEHYR---------- 283
G + T++ Q+L P FL + Y H P + P + + Y
Sbjct: 194 GTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDP 253
Query: 284 -----------------------SIININ--------------RRRYAAMLSCLDEAINN 306
+NI+ R+ Y A +S LD +
Sbjct: 254 EVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGR 313
Query: 307 VTLALKTYGFYNNSIIIYSSDNGGQPTAGG-----SNWPLR----------GSKGTYWEG 351
+ AL N++II ++SD+G G SN+ + G + E
Sbjct: 314 LLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEA 373
Query: 352 GIRAVGFV----HSPLLKNKGTVCKELVHITDWYPTLISLAEGQI 392
G + ++ + L G +LV + +PTL LA Q+
Sbjct: 374 GEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQV 418
>gi|5360208 iduronate-2-sulfatase isoform b precursor [Homo sapiens]
Length = 343
Score = 56.6 bits (135), Expect = 6e-08
Identities = 75/323 (23%), Positives = 124/323 (38%), Gaps = 78/323 (24%)
Query: 69 STTSTSQPHLIFILADDQGFRDVGYHGSE-IKTPTLDKLAAEGVKLENYYVQP-ICTPSR 126
+ ++T +++ I+ DD +G +G + +++P +D+LA+ + +N + Q +C PSR
Sbjct: 30 ANSTTDALNVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSR 88
Query: 127 SQFITGKYQIHTGLQ--HSIIRPTQPNCLPLDNATLPQKLKEVGYSTHMVGK-WHLGF-- 181
F+TG+ T L +S R N +T+PQ KE GY T VGK +H G
Sbjct: 89 VSFLTGRRPDTTRLYDFNSYWRVHAGNF-----STIPQYFKENGYVTMSVGKVFHPGISS 143
Query: 182 YRKECMPTRRGFDTFFGSLLGSGDYYTHYKCDSPG-------MCGYDLYENDNAAWDYDN 234
+ P F + S S Y C P +C D+ D
Sbjct: 144 NHTDDSPYSWSFPPYHPS---SEKYENTKTCRGPDGELHANLLCPVDVL-------DVPE 193
Query: 235 GIYSTQMYTQRVQQILAS-HNPTKPIFLYIAYQAVHSPLQAPGRYFEHYR---------- 283
G + T++ Q+L P FL + Y H P + P + + Y
Sbjct: 194 GTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDP 253
Query: 284 -----------------------SIININ--------------RRRYAAMLSCLDEAINN 306
+NI+ R+ Y A +S LD +
Sbjct: 254 EVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGR 313
Query: 307 VTLALKTYGFYNNSIIIYSSDNG 329
+ AL N++II ++SD+G
Sbjct: 314 LLSALDDLQLANSTIIAFTSDHG 336
>gi|169217295 PREDICTED: similar to iduronate 2-sulfatase (Hunter
syndrome) [Homo sapiens]
Length = 142
Score = 45.1 bits (105), Expect = 2e-04
Identities = 30/82 (36%), Positives = 43/82 (52%), Gaps = 8/82 (9%)
Query: 98 IKTPTLDKLAAEGVKLENYYVQP-ICTPSRSQFITGKYQIHTGLQ--HSIIRPTQPNCLP 154
+K P +D+LA+ + +N + Q +C PSR F+TG+ T L +S R N
Sbjct: 22 VKAPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNF-- 79
Query: 155 LDNATLPQKLKEVGYSTHMVGK 176
+T+PQ KE GY T VGK
Sbjct: 80 ---STIPQYFKENGYVTMSVGK 98
>gi|39930577 arylsulfatase K [Homo sapiens]
Length = 536
Score = 45.1 bits (105), Expect = 2e-04
Identities = 55/241 (22%), Positives = 99/241 (41%), Gaps = 43/241 (17%)
Query: 283 RSIININRRRYAAMLSCLDEAINNVTLALKTYGFYNNSIIIYSSDNGGQPTAGGSNWPLR 342
+ I NI R Y AM + D + + LAL +I+IYSSD+G +
Sbjct: 270 KEIKNI-RAFYYAMCAETDAMLGEIILALHQLDLLQKTIVIYSSDHGELAMEHRQFY--- 325
Query: 343 GSKGTYWEGGIRAVGFVHSPLLKNKGTVCKELVHITDWYPTLISLAEGQIDEDIQLDGYD 402
K + +E + P +K G +V + D YPT++ +A + ++ L GY
Sbjct: 326 --KMSMYEASAHVPLLMMGPGIK-AGLQVSNVVSLVDIYPTMLDIAGIPLPQN--LSGYS 380
Query: 403 IWETISEGLRSPRVDILHNIDPIYTKAKNGSWAAGYGIWNTAIQSAIRVQHWKLLTGNPG 462
+ SE ++ + N+ P + ++ +G A +R HWK + + G
Sbjct: 381 LLPLSSETFKNEHK--VKNLHPPWILSE------FHGCNVNASTYMLRTNHWKYIAYSDG 432
Query: 463 YSDWVPPQSFSNLGPNRWHNERITLSTGKSVWLFNITADPYERVDLSNRYPGIVKKLLRR 522
S + PQ LF++++DP E +++ ++P I L ++
Sbjct: 433 AS--ILPQ------------------------LFDLSSDPDELTNVAVKFPEITYSLDQK 466
Query: 523 L 523
L
Sbjct: 467 L 467
Score = 33.1 bits (74), Expect = 0.75
Identities = 27/112 (24%), Positives = 47/112 (41%), Gaps = 8/112 (7%)
Query: 67 EPSTTSTSQPHLIFILADDQGFRDVGYHGSEI-KTPTLDKLAAEGVKLENYYVQ-PICTP 124
E + P+++ +++D R + GS++ K P ++ + G N Y PIC P
Sbjct: 23 EQRRRAAKAPNVVLVVSDSFDGRLTFHPGSQVVKLPFINFMKTRGTSFLNAYTNSPICCP 82
Query: 125 SRSQFITGKYQIHTGLQHSIIRPTQPNCLPLDNATLPQKLKEVGYSTHMVGK 176
SR+ +G + H + + PN T ++ GY T GK
Sbjct: 83 SRAAMWSGLF-THLTESWNNFKGLDPN-----YTTWMDVMERHGYRTQKFGK 128
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.136 0.434
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,128,305
Number of Sequences: 37866
Number of extensions: 1332590
Number of successful extensions: 9758
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 90
Number of HSP's successfully gapped in prelim test: 29
Number of HSP's that attempted gapping in prelim test: 8080
Number of HSP's gapped (non-prelim): 1144
length of query: 599
length of database: 18,247,518
effective HSP length: 108
effective length of query: 491
effective length of database: 14,157,990
effective search space: 6951573090
effective search space used: 6951573090
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.