Guide to the Human Genome
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Search of human proteins with 14249394

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|14249394 glyoxalase domain containing 1 [Homo sapiens]
         (371 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|14249394 glyoxalase domain containing 1 [Homo sapiens]             751   0.0  
gi|4504477 4-hydroxyphenylpyruvate dioxygenase [Homo sapiens]          98   1e-20
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]                    33   0.31 
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]                    33   0.31 
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]                    33   0.31 
gi|239757962 PREDICTED: hypothetical protein [Homo sapiens]            30   2.7  
gi|188595687 gamma filamin isoform b [Homo sapiens]                    29   5.9  
gi|116805322 gamma filamin isoform a [Homo sapiens]                    29   5.9  
gi|239757043 PREDICTED: functional smad suppressing element 18 [...    29   5.9  
gi|239751555 PREDICTED: functional smad suppressing element 18 [...    29   5.9  
gi|239746067 PREDICTED: functional smad suppressing element 18 [...    29   5.9  

>gi|14249394 glyoxalase domain containing 1 [Homo sapiens]
          Length = 371

 Score =  751 bits (1940), Expect = 0.0
 Identities = 371/371 (100%), Positives = 371/371 (100%)

Query: 1   MAAPALRLCHIAFHVPAGQPLARNLQRLFGFQPLASREVDGWRQLALRSGDAVFLVNEGA 60
           MAAPALRLCHIAFHVPAGQPLARNLQRLFGFQPLASREVDGWRQLALRSGDAVFLVNEGA
Sbjct: 1   MAAPALRLCHIAFHVPAGQPLARNLQRLFGFQPLASREVDGWRQLALRSGDAVFLVNEGA 60

Query: 61  GSGEPLYGLDPRHAVPSATNLCFDVADAGAATRELAALGCSVPVPPVRVRDAQGAATYAV 120
           GSGEPLYGLDPRHAVPSATNLCFDVADAGAATRELAALGCSVPVPPVRVRDAQGAATYAV
Sbjct: 61  GSGEPLYGLDPRHAVPSATNLCFDVADAGAATRELAALGCSVPVPPVRVRDAQGAATYAV 120

Query: 121 VSSPAGILSLTLLERAGYRGPFLPGFRPVSSAPGPGWVSRVDHLTLACTPGSSPTLLRWF 180
           VSSPAGILSLTLLERAGYRGPFLPGFRPVSSAPGPGWVSRVDHLTLACTPGSSPTLLRWF
Sbjct: 121 VSSPAGILSLTLLERAGYRGPFLPGFRPVSSAPGPGWVSRVDHLTLACTPGSSPTLLRWF 180

Query: 181 HDCLGFCHLPLSPGEDPELGLEMTAGFGLGGLRLTALQAQPGSIVPTLVLAESLPGATTR 240
           HDCLGFCHLPLSPGEDPELGLEMTAGFGLGGLRLTALQAQPGSIVPTLVLAESLPGATTR
Sbjct: 181 HDCLGFCHLPLSPGEDPELGLEMTAGFGLGGLRLTALQAQPGSIVPTLVLAESLPGATTR 240

Query: 241 QDQVEQFLARHKGPGLQHVGLYTPNIVEATEGVATAGGQFLAPPGAYYQQPGKERQIRAA 300
           QDQVEQFLARHKGPGLQHVGLYTPNIVEATEGVATAGGQFLAPPGAYYQQPGKERQIRAA
Sbjct: 241 QDQVEQFLARHKGPGLQHVGLYTPNIVEATEGVATAGGQFLAPPGAYYQQPGKERQIRAA 300

Query: 301 GHEPHLLARQGILLDGDKGKFLLQVFTKSLFTEDTFFLELIQRQGATGFGQGNIRALWQS 360
           GHEPHLLARQGILLDGDKGKFLLQVFTKSLFTEDTFFLELIQRQGATGFGQGNIRALWQS
Sbjct: 301 GHEPHLLARQGILLDGDKGKFLLQVFTKSLFTEDTFFLELIQRQGATGFGQGNIRALWQS 360

Query: 361 VQEQSARSQEA 371
           VQEQSARSQEA
Sbjct: 361 VQEQSARSQEA 371


>gi|4504477 4-hydroxyphenylpyruvate dioxygenase [Homo sapiens]
          Length = 393

 Score = 97.8 bits (242), Expect = 1e-20
 Identities = 89/347 (25%), Positives = 161/347 (46%), Gaps = 25/347 (7%)

Query: 30  GFQPLASREVD-GWRQLA---LRSGDAVFLVNEGAGSGEPLYGLDPRHAVPSATNLCFDV 85
           GF+PLA R ++ G R++    ++ G  VF+++          G           ++ F+V
Sbjct: 41  GFEPLAYRGLETGSREVVSHVIKQGKIVFVLSSALNPWNKEMGDHLVKHGDGVKDIAFEV 100

Query: 86  ADAGAATRELAALGCSVPVPPVRVRDAQGAATYAVVSSPAGILSLTLLERAGYRGPFLPG 145
            D     ++    G  +   P   +D  G   +AV+ +  G  + TL+E+  Y G FLPG
Sbjct: 101 EDCDYIVQKARERGAKIMREPWVEQDKFGKVKFAVLQT-YGDTTHTLVEKMNYIGQFLPG 159

Query: 146 FR------PVSSAPGPGWVSRVDHLTLACTPGSSPTLLRWFHDCLGFCHLPLSPGEDPEL 199
           +       P+        +  +DH+          +   W+   L F H   S  +D ++
Sbjct: 160 YEAPAFMDPLLPKLPKCSLEMIDHIVGNQPDQEMVSASEWYLKNLQF-HRFWSV-DDTQV 217

Query: 200 GLEMTAGFGLGGLRLTALQAQPGSIVPTLVLAESLPGATTRQDQVEQFLARHKGPGLQHV 259
             E ++      LR   +     SI   + + E  PG   ++ Q+++++  + G G+QH+
Sbjct: 218 HTEYSS------LRSIVVANYEESI--KMPINEPAPGK--KKSQIQEYVDYNGGAGVQHI 267

Query: 260 GLYTPNIVEATEGVATAGGQFLAPPGAYYQQPGKERQIRAAGHEPHL--LARQGILLDGD 317
            L T +I+ A   +   G +FL+ P  YY+Q  ++ +      + ++  L    IL+D D
Sbjct: 268 ALKTEDIITAIRHLRERGLEFLSVPSTYYKQLREKLKTAKIKVKENIDALEELKILVDYD 327

Query: 318 KGKFLLQVFTKSLFTEDTFFLELIQRQGATGFGQGNIRALWQSVQEQ 364
           +  +LLQ+FTK +    T FLE+IQR    GFG GN  +L+++ +E+
Sbjct: 328 EKGYLLQIFTKPVQDRPTLFLEVIQRHNHQGFGAGNFNSLFKAFEEE 374


>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3874

 Score = 33.5 bits (75), Expect = 0.31
 Identities = 67/243 (27%), Positives = 93/243 (38%), Gaps = 39/243 (16%)

Query: 107 VRVRDAQ--GAATY-AVVSSPAGILSLTLLERAGYRGPFLPGFRPVSSAPGPGWVSRVDH 163
           +R+  AQ   A +Y  V S+ AG   L    R G R    P      S PGP  V+    
Sbjct: 750 LRIEQAQLSDAGSYRCVASNVAGSTEL----RYGLRVNVPPRITLPPSLPGPVLVNTPVR 805

Query: 164 LTLACTPGSSPTLLRWFHDCLGFCHLPLSPGEDPELGLEMTAGFGLGGLRLTALQAQPGS 223
           LT   T   SPTL+ W  D       P+SP   P  GL++      GG  LT   A+   
Sbjct: 806 LTCNATGAPSPTLM-WLKD-----GNPVSPAGTP--GLQVFP----GGRVLTLASARASD 853

Query: 224 IVPTLVLAESLPGATTRQDQVEQFLARHKGPGLQHVGLYTPNIVEATEGVA-TAGGQFLA 282
                 +A S  G    +D+ +  L  H  P +  +G      V A E VA       + 
Sbjct: 854 SGRYSCVAVSAVG----EDRQDVVLQVHMPPSI--LGEELNVSVVANESVALECQSHAMP 907

Query: 283 PPGAYYQQPGKERQIRAAGHEPHLLARQGILLDGDKGKFLLQVFTKSLFTEDTFFLELIQ 342
           PP   + + G+            L  R G+ L  DK   LLQV    ++    +  E + 
Sbjct: 908 PPVLSWWKDGRP-----------LEPRPGVHLSADKA--LLQVDRADVWDAGHYTCEALN 954

Query: 343 RQG 345
           + G
Sbjct: 955 QAG 957


>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 5065

 Score = 33.5 bits (75), Expect = 0.31
 Identities = 67/243 (27%), Positives = 93/243 (38%), Gaps = 39/243 (16%)

Query: 107  VRVRDAQ--GAATY-AVVSSPAGILSLTLLERAGYRGPFLPGFRPVSSAPGPGWVSRVDH 163
            +R+  AQ   A +Y  V S+ AG   L    R G R    P      S PGP  V+    
Sbjct: 1941 LRIEQAQLSDAGSYRCVASNVAGSTEL----RYGLRVNVPPRITLPPSLPGPVLVNTPVR 1996

Query: 164  LTLACTPGSSPTLLRWFHDCLGFCHLPLSPGEDPELGLEMTAGFGLGGLRLTALQAQPGS 223
            LT   T   SPTL+ W  D       P+SP   P  GL++      GG  LT   A+   
Sbjct: 1997 LTCNATGAPSPTLM-WLKD-----GNPVSPAGTP--GLQVFP----GGRVLTLASARASD 2044

Query: 224  IVPTLVLAESLPGATTRQDQVEQFLARHKGPGLQHVGLYTPNIVEATEGVA-TAGGQFLA 282
                  +A S  G    +D+ +  L  H  P +  +G      V A E VA       + 
Sbjct: 2045 SGRYSCVAVSAVG----EDRQDVVLQVHMPPSI--LGEELNVSVVANESVALECQSHAMP 2098

Query: 283  PPGAYYQQPGKERQIRAAGHEPHLLARQGILLDGDKGKFLLQVFTKSLFTEDTFFLELIQ 342
            PP   + + G+            L  R G+ L  DK   LLQV    ++    +  E + 
Sbjct: 2099 PPVLSWWKDGRP-----------LEPRPGVHLSADKA--LLQVDRADVWDAGHYTCEALN 2145

Query: 343  RQG 345
            + G
Sbjct: 2146 QAG 2148


>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3783

 Score = 33.5 bits (75), Expect = 0.31
 Identities = 67/243 (27%), Positives = 93/243 (38%), Gaps = 39/243 (16%)

Query: 107 VRVRDAQ--GAATY-AVVSSPAGILSLTLLERAGYRGPFLPGFRPVSSAPGPGWVSRVDH 163
           +R+  AQ   A +Y  V S+ AG   L    R G R    P      S PGP  V+    
Sbjct: 659 LRIEQAQLSDAGSYRCVASNVAGSTEL----RYGLRVNVPPRITLPPSLPGPVLVNTPVR 714

Query: 164 LTLACTPGSSPTLLRWFHDCLGFCHLPLSPGEDPELGLEMTAGFGLGGLRLTALQAQPGS 223
           LT   T   SPTL+ W  D       P+SP   P  GL++      GG  LT   A+   
Sbjct: 715 LTCNATGAPSPTLM-WLKD-----GNPVSPAGTP--GLQVFP----GGRVLTLASARASD 762

Query: 224 IVPTLVLAESLPGATTRQDQVEQFLARHKGPGLQHVGLYTPNIVEATEGVA-TAGGQFLA 282
                 +A S  G    +D+ +  L  H  P +  +G      V A E VA       + 
Sbjct: 763 SGRYSCVAVSAVG----EDRQDVVLQVHMPPSI--LGEELNVSVVANESVALECQSHAMP 816

Query: 283 PPGAYYQQPGKERQIRAAGHEPHLLARQGILLDGDKGKFLLQVFTKSLFTEDTFFLELIQ 342
           PP   + + G+            L  R G+ L  DK   LLQV    ++    +  E + 
Sbjct: 817 PPVLSWWKDGRP-----------LEPRPGVHLSADKA--LLQVDRADVWDAGHYTCEALN 863

Query: 343 RQG 345
           + G
Sbjct: 864 QAG 866


>gi|239757962 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 136

 Score = 30.4 bits (67), Expect = 2.7
 Identities = 23/79 (29%), Positives = 38/79 (48%), Gaps = 10/79 (12%)

Query: 162 DHLTLACTPGSSPTLLRWFHDCLGFCHLPLSPGEDPELGLEMTAGFGLGGLRLTALQAQP 221
           + + +  TP  S +L   + +  G+C       ++P   L M+  F  GGL  TA +AQ 
Sbjct: 25  NEIIVTATPSCSRSLAA-YTELQGYC------SQNPRKELAMSLPFSGGGLATTAEEAQK 77

Query: 222 ---GSIVPTLVLAESLPGA 237
              GS +   ++A + PGA
Sbjct: 78  RRWGSSLTCSMMAATFPGA 96


>gi|188595687 gamma filamin isoform b [Homo sapiens]
          Length = 2692

 Score = 29.3 bits (64), Expect = 5.9
 Identities = 22/61 (36%), Positives = 29/61 (47%), Gaps = 3/61 (4%)

Query: 65   PLYGLDPRHAVPSATNLCFDVADAGAATRELAALGCSVPVPPVRVRDAQGAATYAVVSSP 124
            P  G   R  VP    +  D + AG A  ++A LG +    PV VRD  G  T+ V  +P
Sbjct: 1451 PGLGAGVRARVPQTFTV--DCSQAGRAPLQVAVLGPTGVAEPVEVRD-NGDGTHTVHYTP 1507

Query: 125  A 125
            A
Sbjct: 1508 A 1508


>gi|116805322 gamma filamin isoform a [Homo sapiens]
          Length = 2725

 Score = 29.3 bits (64), Expect = 5.9
 Identities = 22/61 (36%), Positives = 29/61 (47%), Gaps = 3/61 (4%)

Query: 65   PLYGLDPRHAVPSATNLCFDVADAGAATRELAALGCSVPVPPVRVRDAQGAATYAVVSSP 124
            P  G   R  VP    +  D + AG A  ++A LG +    PV VRD  G  T+ V  +P
Sbjct: 1451 PGLGAGVRARVPQTFTV--DCSQAGRAPLQVAVLGPTGVAEPVEVRD-NGDGTHTVHYTP 1507

Query: 125  A 125
            A
Sbjct: 1508 A 1508


>gi|239757043 PREDICTED: functional smad suppressing element 18
           [Homo sapiens]
          Length = 996

 Score = 29.3 bits (64), Expect = 5.9
 Identities = 35/110 (31%), Positives = 40/110 (36%), Gaps = 20/110 (18%)

Query: 74  AVPSATNLCFDVADAGAATRELAALGCSVPVPPVRVRDAQGAATYAVVSS---PAGILSL 130
           A  +A +LC    DAGAA   L   G              GAA  A +S    PAG    
Sbjct: 413 AAAAAFSLCHKKEDAGAAAEALGGAGAG----------GAGAAPKAGLSGLFWPAGRKDA 462

Query: 131 TLLERAGYRGPFLPGFRPVSS--APGPGWVSRVDHLTLACTPGSSPTLLR 178
                  +  P  PG  PV +   P P   S      L C  G SP LLR
Sbjct: 463 FYPPFCMFWPPRTPGGLPVPTYLQPPPQPPS-----ALGCALGESPALLR 507


>gi|239751555 PREDICTED: functional smad suppressing element 18
           [Homo sapiens]
          Length = 1252

 Score = 29.3 bits (64), Expect = 5.9
 Identities = 35/110 (31%), Positives = 40/110 (36%), Gaps = 20/110 (18%)

Query: 74  AVPSATNLCFDVADAGAATRELAALGCSVPVPPVRVRDAQGAATYAVVSS---PAGILSL 130
           A  +A +LC    DAGAA   L   G              GAA  A +S    PAG    
Sbjct: 413 AAAAAFSLCHKKEDAGAAAEALGGAGAG----------GAGAAPKAGLSGLFWPAGRKDA 462

Query: 131 TLLERAGYRGPFLPGFRPVSS--APGPGWVSRVDHLTLACTPGSSPTLLR 178
                  +  P  PG  PV +   P P   S      L C  G SP LLR
Sbjct: 463 FYPPFCMFWPPRTPGGLPVPTYLQPPPQPPS-----ALGCALGESPALLR 507


>gi|239746067 PREDICTED: functional smad suppressing element 18
           [Homo sapiens]
          Length = 1252

 Score = 29.3 bits (64), Expect = 5.9
 Identities = 35/110 (31%), Positives = 40/110 (36%), Gaps = 20/110 (18%)

Query: 74  AVPSATNLCFDVADAGAATRELAALGCSVPVPPVRVRDAQGAATYAVVSS---PAGILSL 130
           A  +A +LC    DAGAA   L   G              GAA  A +S    PAG    
Sbjct: 413 AAAAAFSLCHKKEDAGAAAEALGGAGAG----------GAGAAPKAGLSGLFWPAGRKDA 462

Query: 131 TLLERAGYRGPFLPGFRPVSS--APGPGWVSRVDHLTLACTPGSSPTLLR 178
                  +  P  PG  PV +   P P   S      L C  G SP LLR
Sbjct: 463 FYPPFCMFWPPRTPGGLPVPTYLQPPPQPPS-----ALGCALGESPALLR 507


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.138    0.425 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,389,069
Number of Sequences: 37866
Number of extensions: 843836
Number of successful extensions: 1798
Number of sequences better than 10.0: 11
Number of HSP's better than 10.0 without gapping: 2
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 1792
Number of HSP's gapped (non-prelim): 17
length of query: 371
length of database: 18,247,518
effective HSP length: 104
effective length of query: 267
effective length of database: 14,309,454
effective search space: 3820624218
effective search space used: 3820624218
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
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