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Search of human proteins with 94721354
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|94721354 methylenetetrahydrofolate dehydrogenase 2 precursor
[Homo sapiens]
(350 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|94721354 methylenetetrahydrofolate dehydrogenase 2 precursor ... 688 0.0
gi|222418558 methylenetetrahydrofolate dehydrogenase 2-like [Hom... 467 e-132
gi|222136639 methylenetetrahydrofolate dehydrogenase 1 [Homo sap... 197 1e-50
gi|36796743 methylenetetrahydrofolate dehydrogenase (NADP+ depen... 72 1e-12
gi|24586663 adaptor protein, phosphotyrosine interaction, PH dom... 35 0.10
gi|114688046 TBC1 domain family, member 4 [Homo sapiens] 31 1.4
gi|183227703 mitochondrial translation optimization 1 homolog is... 29 5.5
gi|19882217 mitochondrial translation optimization 1 homolog iso... 29 5.5
gi|4557317 annexin A11 [Homo sapiens] 29 5.5
gi|74024895 mitochondrial translation optimization 1 homolog iso... 29 5.5
gi|22165433 annexin A11 [Homo sapiens] 29 5.5
gi|22165431 annexin A11 [Homo sapiens] 29 5.5
gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo sa... 29 7.2
gi|169173200 PREDICTED: hypothetical protein LOC100128993 [Homo ... 29 7.2
gi|169172442 PREDICTED: hypothetical protein LOC100128993 [Homo ... 29 7.2
gi|169172830 PREDICTED: hypothetical protein LOC100128993 [Homo ... 29 7.2
>gi|94721354 methylenetetrahydrofolate dehydrogenase 2 precursor
[Homo sapiens]
Length = 350
Score = 688 bits (1775), Expect = 0.0
Identities = 350/350 (100%), Positives = 350/350 (100%)
Query: 1 MAATSLMSALAARLLQPAHSCSLRLRPFHLAAVRNEAVVISGRKLAQQIKQEVRQEVEEW 60
MAATSLMSALAARLLQPAHSCSLRLRPFHLAAVRNEAVVISGRKLAQQIKQEVRQEVEEW
Sbjct: 1 MAATSLMSALAARLLQPAHSCSLRLRPFHLAAVRNEAVVISGRKLAQQIKQEVRQEVEEW 60
Query: 61 VASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVGINSETIMKPASISEEELLNLINKL 120
VASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVGINSETIMKPASISEEELLNLINKL
Sbjct: 61 VASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVGINSETIMKPASISEEELLNLINKL 120
Query: 121 NNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDGFHVINVGRMCLDQYSMLPATPWGV 180
NNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDGFHVINVGRMCLDQYSMLPATPWGV
Sbjct: 121 NNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDGFHVINVGRMCLDQYSMLPATPWGV 180
Query: 181 WEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQL 240
WEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQL
Sbjct: 181 WEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQL 240
Query: 241 KKHTILADIVISAAGIPNLITADMIKEGAAVIDVGINRVHDPVTAKPKLVGDVDFEGVRQ 300
KKHTILADIVISAAGIPNLITADMIKEGAAVIDVGINRVHDPVTAKPKLVGDVDFEGVRQ
Sbjct: 241 KKHTILADIVISAAGIPNLITADMIKEGAAVIDVGINRVHDPVTAKPKLVGDVDFEGVRQ 300
Query: 301 KAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLEEREVLKSKELGVATN 350
KAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLEEREVLKSKELGVATN
Sbjct: 301 KAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLEEREVLKSKELGVATN 350
>gi|222418558 methylenetetrahydrofolate dehydrogenase 2-like [Homo
sapiens]
Length = 347
Score = 467 bits (1202), Expect = e-132
Identities = 221/307 (71%), Positives = 270/307 (87%)
Query: 26 RPFHLAAVRNEAVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYV 85
R F + VR+EA++ISG ++A+ I++E+++ VE WV+ GN+RPHLS+ILVG+NPASH+YV
Sbjct: 40 RGFRSSGVRHEAIIISGTEMAKHIQKEIQRGVESWVSLGNRRPHLSIILVGDNPASHTYV 99
Query: 86 LNKTRAAAVVGINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRIC 145
NK RAA+ VGI SE I+KP +S+EELL++ ++LN D V G+LVQLPLP+H+DER IC
Sbjct: 100 RNKIRAASAVGICSELILKPKDVSQEELLDVTDQLNMDPRVSGILVQLPLPDHVDERTIC 159
Query: 146 NAVSPDKDVDGFHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNV 205
N ++P+KDVDGFH+IN+GR+CLDQ+S++PAT VWEIIKRTGI T GKNVVVAGRSKNV
Sbjct: 160 NGIAPEKDVDGFHIINIGRLCLDQHSLIPATASAVWEIIKRTGIQTFGKNVVVAGRSKNV 219
Query: 206 GMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMI 265
GMPIAMLLHTDG HERPGGDATVTI+HRYTPKEQLK HT LADI+I AAGIP LIT+DM+
Sbjct: 220 GMPIAMLLHTDGEHERPGGDATVTIAHRYTPKEQLKIHTQLADIIIVAAGIPKLITSDMV 279
Query: 266 KEGAAVIDVGINRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTI 325
KEGAAVIDVGIN VHDPVT K KLVGDVDFE V++KAG+ITPVPGGVGPMTVAML+KNT+
Sbjct: 280 KEGAAVIDVGINYVHDPVTGKTKLVGDVDFEAVKKKAGFITPVPGGVGPMTVAMLLKNTL 339
Query: 326 IAAKKVL 332
+AAKK++
Sbjct: 340 LAAKKII 346
>gi|222136639 methylenetetrahydrofolate dehydrogenase 1 [Homo
sapiens]
Length = 935
Score = 197 bits (501), Expect = 1e-50
Identities = 119/304 (39%), Positives = 177/304 (58%), Gaps = 20/304 (6%)
Query: 37 AVVISGRKLAQQIKQEVRQEVEEWVAS-GNKRPHLSVILVGENPASHSYVLNKTRAAAVV 95
A +++G++++ QI+ ++ +V + P L+++ VG S+ Y+ K +AA +
Sbjct: 4 AEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEI 63
Query: 96 GINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEH--IDERRICNAVSPDKD 153
GI + I P + +E E++ I LN D V G LVQLPL I+ + NA++P+KD
Sbjct: 64 GIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKD 123
Query: 154 VDGFHVINVGRMCLDQYS--MLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAM 211
VDG IN G++ + +P TP G E+IK TG+P G++ VV GRSK VG P+
Sbjct: 124 VDGLTSINAGKLARGDLNDCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAPMHD 183
Query: 212 LLHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAV 271
LL + +ATVT H T L + DI++ A G P ++ + IK GA V
Sbjct: 184 LLLWN--------NATVTTCHSKTA--HLDEEVNKGDILVVATGQPEMVKGEWIKPGAIV 233
Query: 272 IDVGINRVHDPVTAKP---KLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAA 328
ID GIN V D KP K+VGDV ++ +++A +ITPVPGGVGPMTVAMLM++T+ +A
Sbjct: 234 IDCGINYVPDD--KKPNGRKVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESA 291
Query: 329 KKVL 332
K+ L
Sbjct: 292 KRFL 295
>gi|36796743 methylenetetrahydrofolate dehydrogenase (NADP+
dependent) 1-like [Homo sapiens]
Length = 978
Score = 71.6 bits (174), Expect = 1e-12
Identities = 60/222 (27%), Positives = 106/222 (47%), Gaps = 21/222 (9%)
Query: 67 RPHLSVILVGENPASHSYVLNKTRAAAVVGINSETIMKPASISEEELLNLINKLNNDDNV 126
+P L++I G++ N A G+N I P SE E+++ I K+N D V
Sbjct: 97 KPVLAIIQAGDDNLMQEINQNLAEEA---GLNITHICLPPDSSEAEIIDEILKINEDTRV 153
Query: 127 DGLLVQLPLPEHIDERRICNAVSPDKDVDGFHVINVGRMCLDQYSMLPATP--WGVWEII 184
GL +Q+ E++ ++ NA+ P+KDVDG IN+G++ +P V E++
Sbjct: 154 HGLALQIS--ENLFSNKVLNALKPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELL 211
Query: 185 KRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQLKKHT 244
+++G+ GK ++V G ++ + L G ++T+S ++ + QL+
Sbjct: 212 EKSGVNLDGKKILVVGAHGSLEAALQCLFQRKG---------SMTMSIQWKTR-QLQSKL 261
Query: 245 ILADIVISAAGIPNLITADMIKEGAAVIDVGINRVHDPVTAK 286
ADIV+ + P I I+ G V +N HD ++ K
Sbjct: 262 HEADIVVLGSPKPEEIPLTWIQPGTTV----LNCSHDFLSGK 299
>gi|24586663 adaptor protein, phosphotyrosine interaction, PH domain
and leucine zipper containing 2 [Homo sapiens]
Length = 664
Score = 35.0 bits (79), Expect = 0.10
Identities = 35/138 (25%), Positives = 58/138 (42%), Gaps = 17/138 (12%)
Query: 9 ALAARLLQPAHSCSL-------RLRPFHLAAVRNEAVVISGRKLAQQIKQEVRQEVEEWV 61
A+A L+Q +CS+ R F + ++ +I ++ E R+E EEW+
Sbjct: 316 AVAGGLIQDLDNCSVMAVDCEDRRYCFQITTPNGKSGII--------LQAESRKENEEWI 367
Query: 62 ASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVGINSETIMKPASISEEELLNLINKLN 121
+ N I + +NP + + LN+T AV I S + +S + L N +
Sbjct: 368 CAINNISRQ--IYLTDNPEAVAIKLNQTALQAVTPITSFGKKQESSCPSQNLKNSEMENE 425
Query: 122 NDDNVDGLLVQLPLPEHI 139
ND V LP E +
Sbjct: 426 NDKIVPKATASLPEAEEL 443
>gi|114688046 TBC1 domain family, member 4 [Homo sapiens]
Length = 1298
Score = 31.2 bits (69), Expect = 1.4
Identities = 21/62 (33%), Positives = 29/62 (46%), Gaps = 2/62 (3%)
Query: 134 PLPEHID-ERRICNAVSPDKDVDG-FHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPT 191
P P ++ E + P K D F + VG CLD + LP PW + EI +R+ P
Sbjct: 11 PFPHPLEPEPGVSAQPGPGKPSDKRFRLWYVGGSCLDHRTTLPMLPWLMAEIRRRSQKPE 70
Query: 192 LG 193
G
Sbjct: 71 AG 72
>gi|183227703 mitochondrial translation optimization 1 homolog
isoform c [Homo sapiens]
Length = 732
Score = 29.3 bits (64), Expect = 5.5
Identities = 20/71 (28%), Positives = 35/71 (49%), Gaps = 1/71 (1%)
Query: 82 HSYVLNKTRAAAVVGINSETIMKPASIS-EEELLNLINKLNNDDNVDGLLVQLPLPEHID 140
H VLN+ + AV G+ ++ K + ++E+LN + V+ L++ P PEH
Sbjct: 110 HYKVLNRRKGPAVWGLRAQIDRKLYKQNMQKEILNTPLLTVQEGAVEDLILTEPEPEHTG 169
Query: 141 ERRICNAVSPD 151
+ R+ V D
Sbjct: 170 KCRVSGVVLVD 180
>gi|19882217 mitochondrial translation optimization 1 homolog
isoform b [Homo sapiens]
Length = 717
Score = 29.3 bits (64), Expect = 5.5
Identities = 20/71 (28%), Positives = 35/71 (49%), Gaps = 1/71 (1%)
Query: 82 HSYVLNKTRAAAVVGINSETIMKPASIS-EEELLNLINKLNNDDNVDGLLVQLPLPEHID 140
H VLN+ + AV G+ ++ K + ++E+LN + V+ L++ P PEH
Sbjct: 110 HYKVLNRRKGPAVWGLRAQIDRKLYKQNMQKEILNTPLLTVQEGAVEDLILTEPEPEHTG 169
Query: 141 ERRICNAVSPD 151
+ R+ V D
Sbjct: 170 KCRVSGVVLVD 180
>gi|4557317 annexin A11 [Homo sapiens]
Length = 505
Score = 29.3 bits (64), Expect = 5.5
Identities = 28/90 (31%), Positives = 47/90 (52%), Gaps = 12/90 (13%)
Query: 29 HLAAVRNEAVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGEN-PASHSYVLN 87
HL AV NE ++GR + + I +E+ ++EE + L+V+ +N PA + LN
Sbjct: 390 HLVAVFNEYQRMTGRDIEKSICREMSGDLEEGM--------LAVVKCLKNTPAFFAERLN 441
Query: 88 KTRAAAVVGINSETIMK-PASISEEELLNL 116
K A G T+++ S SE +LL++
Sbjct: 442 KAMRGA--GTKDRTLIRIMVSRSETDLLDI 469
>gi|74024895 mitochondrial translation optimization 1 homolog
isoform a [Homo sapiens]
Length = 692
Score = 29.3 bits (64), Expect = 5.5
Identities = 20/71 (28%), Positives = 35/71 (49%), Gaps = 1/71 (1%)
Query: 82 HSYVLNKTRAAAVVGINSETIMKPASIS-EEELLNLINKLNNDDNVDGLLVQLPLPEHID 140
H VLN+ + AV G+ ++ K + ++E+LN + V+ L++ P PEH
Sbjct: 110 HYKVLNRRKGPAVWGLRAQIDRKLYKQNMQKEILNTPLLTVQEGAVEDLILTEPEPEHTG 169
Query: 141 ERRICNAVSPD 151
+ R+ V D
Sbjct: 170 KCRVSGVVLVD 180
>gi|22165433 annexin A11 [Homo sapiens]
Length = 505
Score = 29.3 bits (64), Expect = 5.5
Identities = 28/90 (31%), Positives = 47/90 (52%), Gaps = 12/90 (13%)
Query: 29 HLAAVRNEAVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGEN-PASHSYVLN 87
HL AV NE ++GR + + I +E+ ++EE + L+V+ +N PA + LN
Sbjct: 390 HLVAVFNEYQRMTGRDIEKSICREMSGDLEEGM--------LAVVKCLKNTPAFFAERLN 441
Query: 88 KTRAAAVVGINSETIMK-PASISEEELLNL 116
K A G T+++ S SE +LL++
Sbjct: 442 KAMRGA--GTKDRTLIRIMVSRSETDLLDI 469
>gi|22165431 annexin A11 [Homo sapiens]
Length = 505
Score = 29.3 bits (64), Expect = 5.5
Identities = 28/90 (31%), Positives = 47/90 (52%), Gaps = 12/90 (13%)
Query: 29 HLAAVRNEAVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGEN-PASHSYVLN 87
HL AV NE ++GR + + I +E+ ++EE + L+V+ +N PA + LN
Sbjct: 390 HLVAVFNEYQRMTGRDIEKSICREMSGDLEEGM--------LAVVKCLKNTPAFFAERLN 441
Query: 88 KTRAAAVVGINSETIMK-PASISEEELLNL 116
K A G T+++ S SE +LL++
Sbjct: 442 KAMRGA--GTKDRTLIRIMVSRSETDLLDI 469
>gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo
sapiens]
Length = 1070
Score = 28.9 bits (63), Expect = 7.2
Identities = 12/51 (23%), Positives = 29/51 (56%)
Query: 85 VLNKTRAAAVVGINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPL 135
V++ + A + +NS + A+ +++ LLN + + N+ D++D + + L
Sbjct: 853 VVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEEFTL 903
>gi|169173200 PREDICTED: hypothetical protein LOC100128993 [Homo
sapiens]
Length = 143
Score = 28.9 bits (63), Expect = 7.2
Identities = 19/69 (27%), Positives = 31/69 (44%), Gaps = 6/69 (8%)
Query: 5 SLMSALAARLLQPAH-----SCSLRLRPFHLAAVRNEAVVISG-RKLAQQIKQEVRQEVE 58
SL + P+H S SL L P H V NE++++ R+L K++ +
Sbjct: 12 SLQEEKSGAASNPSHWGNLLSISLALAPGHTTQVSNESLILKNKRRLTTDPKRKQEYNLR 71
Query: 59 EWVASGNKR 67
W A+ +R
Sbjct: 72 SWWATRGQR 80
>gi|169172442 PREDICTED: hypothetical protein LOC100128993 [Homo
sapiens]
Length = 143
Score = 28.9 bits (63), Expect = 7.2
Identities = 19/69 (27%), Positives = 31/69 (44%), Gaps = 6/69 (8%)
Query: 5 SLMSALAARLLQPAH-----SCSLRLRPFHLAAVRNEAVVISG-RKLAQQIKQEVRQEVE 58
SL + P+H S SL L P H V NE++++ R+L K++ +
Sbjct: 12 SLQEEKSGAASNPSHWGNLLSISLALAPGHTTQVSNESLILKNKRRLTTDPKRKQEYNLR 71
Query: 59 EWVASGNKR 67
W A+ +R
Sbjct: 72 SWWATRGQR 80
>gi|169172830 PREDICTED: hypothetical protein LOC100128993 [Homo
sapiens]
Length = 143
Score = 28.9 bits (63), Expect = 7.2
Identities = 19/69 (27%), Positives = 31/69 (44%), Gaps = 6/69 (8%)
Query: 5 SLMSALAARLLQPAH-----SCSLRLRPFHLAAVRNEAVVISG-RKLAQQIKQEVRQEVE 58
SL + P+H S SL L P H V NE++++ R+L K++ +
Sbjct: 12 SLQEEKSGAASNPSHWGNLLSISLALAPGHTTQVSNESLILKNKRRLTTDPKRKQEYNLR 71
Query: 59 EWVASGNKR 67
W A+ +R
Sbjct: 72 SWWATRGQR 80
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.383
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,894,784
Number of Sequences: 37866
Number of extensions: 579002
Number of successful extensions: 1221
Number of sequences better than 10.0: 16
Number of HSP's better than 10.0 without gapping: 6
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 1210
Number of HSP's gapped (non-prelim): 16
length of query: 350
length of database: 18,247,518
effective HSP length: 103
effective length of query: 247
effective length of database: 14,347,320
effective search space: 3543788040
effective search space used: 3543788040
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.