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Search of human proteins with 89276756
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|89276756 serine/threonine-protein kinase PRP4K [Homo
sapiens]
(1007 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens] 1982 0.0
gi|169217213 PREDICTED: similar to hCG1820375 [Homo sapiens] 217 4e-56
gi|169216400 PREDICTED: similar to hCG1820375 [Homo sapiens] 217 4e-56
gi|169216858 PREDICTED: hypothetical protein LOC653155 [Homo sap... 217 4e-56
gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulat... 174 5e-43
gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation regul... 173 8e-43
gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulat... 173 8e-43
gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulat... 172 2e-42
gi|114796630 homeodomain interacting protein kinase 3 isoform 2 ... 171 4e-42
gi|114796624 homeodomain interacting protein kinase 3 isoform 1 ... 171 4e-42
gi|47717134 CDC-like kinase 2 [Homo sapiens] 170 5e-42
gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regula... 169 9e-42
gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regula... 169 9e-42
gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regula... 169 9e-42
gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regula... 169 9e-42
gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regula... 169 9e-42
gi|164420691 homeodomain interacting protein kinase 2 isoform 2 ... 169 2e-41
gi|164420685 homeodomain interacting protein kinase 2 isoform 1 ... 169 2e-41
gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulat... 169 2e-41
gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regula... 166 1e-40
gi|38201640 homeodomain-interacting protein kinase 1 isoform 1 [... 165 2e-40
gi|38201638 homeodomain-interacting protein kinase 1 isoform 2 [... 165 2e-40
gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regula... 162 2e-39
gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regula... 162 2e-39
gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens] 159 1e-38
gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens] 159 1e-38
gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens] 155 2e-37
gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens] 155 2e-37
gi|10190706 CDC-like kinase 4 [Homo sapiens] 154 3e-37
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 145 1e-34
>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
Length = 1007
Score = 1982 bits (5136), Expect = 0.0
Identities = 1007/1007 (100%), Positives = 1007/1007 (100%)
Query: 1 MAAAETQSLREQPEMEDANSEKSINEENGEVSEDQSQNKHSRHKKKKHKHRSKHKKHKHS 60
MAAAETQSLREQPEMEDANSEKSINEENGEVSEDQSQNKHSRHKKKKHKHRSKHKKHKHS
Sbjct: 1 MAAAETQSLREQPEMEDANSEKSINEENGEVSEDQSQNKHSRHKKKKHKHRSKHKKHKHS 60
Query: 61 SEEDKDKKHKHKHKHKKHKRKEIIDASDKEGMSPAKRTKLDDLALLEDLEKQRALIKAEL 120
SEEDKDKKHKHKHKHKKHKRKEIIDASDKEGMSPAKRTKLDDLALLEDLEKQRALIKAEL
Sbjct: 61 SEEDKDKKHKHKHKHKKHKRKEIIDASDKEGMSPAKRTKLDDLALLEDLEKQRALIKAEL 120
Query: 121 DNELMEGKVQSGMGLILQGYESGSEEEGEIHEKARNGNRSSTRSSSTKGKLELVDNKITT 180
DNELMEGKVQSGMGLILQGYESGSEEEGEIHEKARNGNRSSTRSSSTKGKLELVDNKITT
Sbjct: 121 DNELMEGKVQSGMGLILQGYESGSEEEGEIHEKARNGNRSSTRSSSTKGKLELVDNKITT 180
Query: 181 KKRSKSRSKERTRHRSDKKKSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSK 240
KKRSKSRSKERTRHRSDKKKSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSK
Sbjct: 181 KKRSKSRSKERTRHRSDKKKSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSK 240
Query: 241 SPTLRRRSQEKIGKARSPTDDKVKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRG 300
SPTLRRRSQEKIGKARSPTDDKVKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRG
Sbjct: 241 SPTLRRRSQEKIGKARSPTDDKVKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRG 300
Query: 301 KSKDRRSRSKERKSKRSETDKEKKPIKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKPR 360
KSKDRRSRSKERKSKRSETDKEKKPIKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKPR
Sbjct: 301 KSKDRRSRSKERKSKRSETDKEKKPIKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKPR 360
Query: 361 DKSRRSRSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDI 420
DKSRRSRSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDI
Sbjct: 361 DKSRRSRSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDI 420
Query: 421 LSRRERSKDASPINRWSPTRRRSRSPIRRRSRSPLRRSRSPRRRSRSPRRRDRGRRSRSR 480
LSRRERSKDASPINRWSPTRRRSRSPIRRRSRSPLRRSRSPRRRSRSPRRRDRGRRSRSR
Sbjct: 421 LSRRERSKDASPINRWSPTRRRSRSPIRRRSRSPLRRSRSPRRRSRSPRRRDRGRRSRSR 480
Query: 481 LRRRSRSRGGRRRRSRSKVKEDKFKGSLSEGMKVEQESSSDDNLEDFDVEEEDEEALIEQ 540
LRRRSRSRGGRRRRSRSKVKEDKFKGSLSEGMKVEQESSSDDNLEDFDVEEEDEEALIEQ
Sbjct: 481 LRRRSRSRGGRRRRSRSKVKEDKFKGSLSEGMKVEQESSSDDNLEDFDVEEEDEEALIEQ 540
Query: 541 RRIQRQAIVQKYKYLAEDSNMSVPSEPSSPQSSTRTRSPSPDDILERVAADVKEYERENV 600
RRIQRQAIVQKYKYLAEDSNMSVPSEPSSPQSSTRTRSPSPDDILERVAADVKEYERENV
Sbjct: 541 RRIQRQAIVQKYKYLAEDSNMSVPSEPSSPQSSTRTRSPSPDDILERVAADVKEYERENV 600
Query: 601 DTFEASVKAKHNLMTVEQNNGSSQKKLLAPDMFTESDDMFAAYFDSARLRAAGIGKDFKE 660
DTFEASVKAKHNLMTVEQNNGSSQKKLLAPDMFTESDDMFAAYFDSARLRAAGIGKDFKE
Sbjct: 601 DTFEASVKAKHNLMTVEQNNGSSQKKLLAPDMFTESDDMFAAYFDSARLRAAGIGKDFKE 660
Query: 661 NPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIR 720
NPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIR
Sbjct: 661 NPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIR 720
Query: 721 NNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKK 780
NNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKK
Sbjct: 721 NNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKK 780
Query: 781 YGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASH 840
YGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASH
Sbjct: 781 YGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASH 840
Query: 841 VADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKL 900
VADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKL
Sbjct: 841 VADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKL 900
Query: 901 AMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLI 960
AMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLI
Sbjct: 901 AMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLI 960
Query: 961 GCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQEKI 1007
GCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQEKI
Sbjct: 961 GCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQEKI 1007
>gi|169217213 PREDICTED: similar to hCG1820375 [Homo sapiens]
Length = 111
Score = 217 bits (553), Expect = 4e-56
Identities = 108/111 (97%), Positives = 110/111 (99%)
Query: 897 MLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLL 956
MLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNF YIE+DKVTEREKVTV+STINPTKDLL
Sbjct: 1 MLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFRYIEIDKVTEREKVTVISTINPTKDLL 60
Query: 957 ADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQEKI 1007
ADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQEKI
Sbjct: 61 ADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQEKI 111
>gi|169216400 PREDICTED: similar to hCG1820375 [Homo sapiens]
Length = 111
Score = 217 bits (553), Expect = 4e-56
Identities = 108/111 (97%), Positives = 110/111 (99%)
Query: 897 MLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLL 956
MLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNF YIE+DKVTEREKVTV+STINPTKDLL
Sbjct: 1 MLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFRYIEIDKVTEREKVTVISTINPTKDLL 60
Query: 957 ADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQEKI 1007
ADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQEKI
Sbjct: 61 ADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQEKI 111
>gi|169216858 PREDICTED: hypothetical protein LOC653155 [Homo sapiens]
Length = 111
Score = 217 bits (553), Expect = 4e-56
Identities = 108/111 (97%), Positives = 110/111 (99%)
Query: 897 MLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLL 956
MLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNF YIE+DKVTEREKVTV+STINPTKDLL
Sbjct: 1 MLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFRYIEIDKVTEREKVTVISTINPTKDLL 60
Query: 957 ADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQEKI 1007
ADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQEKI
Sbjct: 61 ADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQEKI 111
>gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform c [Homo sapiens]
Length = 601
Score = 174 bits (440), Expect = 5e-43
Identities = 118/349 (33%), Positives = 183/349 (52%), Gaps = 30/349 (8%)
Query: 659 KENPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKI 718
KE L + D Y V GE +RY + G+G F VV+A D+ + + VA+KI
Sbjct: 83 KEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDH-QTQELVAIKI 141
Query: 719 IRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVL 778
I+N + EL L+ +N D + K++ + L RHF + HLCLVFE LS NL ++L
Sbjct: 142 IKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLL 201
Query: 779 KKYGKDVGLHIKAVRSYSQQLFLALKLLK--RCNILHADIKPDNILV-NESKTILKLCDF 835
+ G+ + R +QQL AL L +I+H D+KP+NIL+ N ++ +K+ DF
Sbjct: 202 RNTHFR-GVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF 260
Query: 836 GSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNN 895
GS+ + I Y+ SRFYR+PE+++G YD IDMWS+GC L E++TG+ LF G
Sbjct: 261 GSSCQLGQR-IYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEV 319
Query: 896 HMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDL 955
+ +++ G P M+ + ++F++ + T+ TK+L
Sbjct: 320 DQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGW----------------TLRRTKEL 363
Query: 956 LADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQ 1004
D G P +R + +DL+ ++L +PA RIS ALQH F +
Sbjct: 364 RKDYQG----PGTRRLQ----EDLVLRMLEYEPAARISPLGALQHGFFR 404
>gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 2 isoform 2 [Homo sapiens]
Length = 601
Score = 173 bits (438), Expect = 8e-43
Identities = 128/422 (30%), Positives = 210/422 (49%), Gaps = 34/422 (8%)
Query: 599 NVDTFEASVKAKHNLMTVEQNNGSSQKKLLA---PDMFTESDDMFAAYFDSARLRAAGIG 655
++ + E K K MT EQ +KL A ++F+ + F R G
Sbjct: 139 SLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTG-- 196
Query: 656 KDFKENPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVA 715
PN + D +G Y + + RY V G+G F VV+A D+ + +Q VA
Sbjct: 197 -----GPN-NGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDH-KVHQHVA 249
Query: 716 VKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLR 775
+K++RN + + +E+ L+ L D D+ + + + +F + H+C+ FE LSMNL
Sbjct: 250 LKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLY 309
Query: 776 EVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNES-KTILKLCD 834
E++KK K G + VR ++ + L L + I+H D+KP+NIL+ + ++ +K+ D
Sbjct: 310 ELIKK-NKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVID 368
Query: 835 FGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTN 894
FGS+ + T Y+ SRFYRAPE+I+G Y IDMWS+GC L EL TG L PG+
Sbjct: 369 FGSSCYEHQRVYT-YIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDE 427
Query: 895 NHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNF-MYIEVDKVTEREKVTVMSTINPTK 953
L ++L G MP++ + + ++F + + Y V +++ V +N +
Sbjct: 428 GDQLACMIELLG-MPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVV-----LNGGR 481
Query: 954 DLLADLIGCQRLPEDQRKKVHQLK--------DLLDQILMLDPAKRISINQALQHAFIQE 1005
L G P + R+ + LK D L Q L DPA R++ QAL+H +++
Sbjct: 482 SRRGKLRG----PPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRR 537
Query: 1006 KI 1007
++
Sbjct: 538 RL 539
>gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 2 isoform 1 [Homo sapiens]
Length = 528
Score = 173 bits (438), Expect = 8e-43
Identities = 128/422 (30%), Positives = 210/422 (49%), Gaps = 34/422 (8%)
Query: 599 NVDTFEASVKAKHNLMTVEQNNGSSQKKLLA---PDMFTESDDMFAAYFDSARLRAAGIG 655
++ + E K K MT EQ +KL A ++F+ + F R G
Sbjct: 66 SLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTG-- 123
Query: 656 KDFKENPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVA 715
PN + D +G Y + + RY V G+G F VV+A D+ + +Q VA
Sbjct: 124 -----GPN-NGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDH-KVHQHVA 176
Query: 716 VKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLR 775
+K++RN + + +E+ L+ L D D+ + + + +F + H+C+ FE LSMNL
Sbjct: 177 LKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLY 236
Query: 776 EVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNES-KTILKLCD 834
E++KK K G + VR ++ + L L + I+H D+KP+NIL+ + ++ +K+ D
Sbjct: 237 ELIKK-NKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVID 295
Query: 835 FGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTN 894
FGS+ + T Y+ SRFYRAPE+I+G Y IDMWS+GC L EL TG L PG+
Sbjct: 296 FGSSCYEHQRVYT-YIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDE 354
Query: 895 NHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNF-MYIEVDKVTEREKVTVMSTINPTK 953
L ++L G MP++ + + ++F + + Y V +++ V +N +
Sbjct: 355 GDQLACMIELLG-MPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVV-----LNGGR 408
Query: 954 DLLADLIGCQRLPEDQRKKVHQLK--------DLLDQILMLDPAKRISINQALQHAFIQE 1005
L G P + R+ + LK D L Q L DPA R++ QAL+H +++
Sbjct: 409 SRRGKLRG----PPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRR 464
Query: 1006 KI 1007
++
Sbjct: 465 RL 466
>gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform a [Homo sapiens]
Length = 629
Score = 172 bits (435), Expect = 2e-42
Identities = 119/358 (33%), Positives = 183/358 (51%), Gaps = 20/358 (5%)
Query: 659 KENPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKI 718
KE L + D Y V GE +RY + G+G F VV+A D+ + + VA+KI
Sbjct: 83 KEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDH-QTQELVAIKI 141
Query: 719 IRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVL 778
I+N + EL L+ +N D + K++ + L RHF + HLCLVFE LS NL ++L
Sbjct: 142 IKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLL 201
Query: 779 KKYGKDVGLHIKAVRSYSQQLFLALKLLK--RCNILHADIKPDNILV-NESKTILKLCDF 835
+ G+ + R +QQL AL L +I+H D+KP+NIL+ N ++ +K+ DF
Sbjct: 202 RNTHFR-GVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF 260
Query: 836 GSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNN 895
GS+ + I Y+ SRFYR+PE+++G YD IDMWS+GC L E++TG+ LF G
Sbjct: 261 GSSCQLGQR-IYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEV 319
Query: 896 HMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDL 955
+ +++ G P M+ + ++F++ + R K P
Sbjct: 320 DQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGW-----TLRRTKELRKDYQGPGTRR 374
Query: 956 LADLIGCQ-------RLPEDQRKKVHQLK--DLLDQILMLDPAKRISINQALQHAFIQ 1004
L +++G Q R E L+ DL+ ++L +PA RIS ALQH F +
Sbjct: 375 LQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFR 432
>gi|114796630 homeodomain interacting protein kinase 3 isoform 2 [Homo
sapiens]
Length = 1194
Score = 171 bits (432), Expect = 4e-42
Identities = 115/362 (31%), Positives = 186/362 (51%), Gaps = 25/362 (6%)
Query: 665 RDNWTDAEGYYRVNIGEVL---DKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRN 721
+ N T EG Y++ EVL Y V + G+G F VV+ N+ VA+KI++N
Sbjct: 172 KQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRG-TNEIVAIKILKN 230
Query: 722 NELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKY 781
+ + G E+ L +L+ + D+ ++ +R + F H+ H CLVFE L NL + LK+
Sbjct: 231 HPSYARQGQIEVSILARLSTENADE-YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQ- 288
Query: 782 GKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNE---SKTILKLCDFGSA 838
K L +K +R QQ+ ALK LK ++HAD+KP+NI++ + +K+ DFGSA
Sbjct: 289 NKFSPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSA 348
Query: 839 SHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHML 898
SHV+ + YL SR+YRAPEII+G + IDMWS+GC + EL+ G L+PG +
Sbjct: 349 SHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQI 408
Query: 899 KLAMDLKGKMPNKMIRKGVFKDQHF--DQNLNFMYIEVDKVTEREKVTVMSTINPTK--- 953
+ +G +++ G + F + +++ + + E E T M + K
Sbjct: 409 RYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIF 468
Query: 954 ---------DLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQ 1004
+ + DL G L E ++ + LL ++L++D RI+ + L H F+
Sbjct: 469 NSLDDVAHVNTVMDLEGSDLLAEKADRR--EFVSLLKKMLLIDADLRITPAETLNHPFVN 526
Query: 1005 EK 1006
K
Sbjct: 527 MK 528
>gi|114796624 homeodomain interacting protein kinase 3 isoform 1 [Homo
sapiens]
Length = 1215
Score = 171 bits (432), Expect = 4e-42
Identities = 115/362 (31%), Positives = 186/362 (51%), Gaps = 25/362 (6%)
Query: 665 RDNWTDAEGYYRVNIGEVL---DKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRN 721
+ N T EG Y++ EVL Y V + G+G F VV+ N+ VA+KI++N
Sbjct: 172 KQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRG-TNEIVAIKILKN 230
Query: 722 NELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKY 781
+ + G E+ L +L+ + D+ ++ +R + F H+ H CLVFE L NL + LK+
Sbjct: 231 HPSYARQGQIEVSILARLSTENADE-YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQ- 288
Query: 782 GKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNE---SKTILKLCDFGSA 838
K L +K +R QQ+ ALK LK ++HAD+KP+NI++ + +K+ DFGSA
Sbjct: 289 NKFSPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSA 348
Query: 839 SHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHML 898
SHV+ + YL SR+YRAPEII+G + IDMWS+GC + EL+ G L+PG +
Sbjct: 349 SHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQI 408
Query: 899 KLAMDLKGKMPNKMIRKGVFKDQHF--DQNLNFMYIEVDKVTEREKVTVMSTINPTK--- 953
+ +G +++ G + F + +++ + + E E T M + K
Sbjct: 409 RYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIF 468
Query: 954 ---------DLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQ 1004
+ + DL G L E ++ + LL ++L++D RI+ + L H F+
Sbjct: 469 NSLDDVAHVNTVMDLEGSDLLAEKADRR--EFVSLLKKMLLIDADLRITPAETLNHPFVN 526
Query: 1005 EK 1006
K
Sbjct: 527 MK 528
>gi|47717134 CDC-like kinase 2 [Homo sapiens]
Length = 498
Score = 170 bits (431), Expect = 5e-42
Identities = 110/351 (31%), Positives = 182/351 (51%), Gaps = 36/351 (10%)
Query: 670 DAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTG 729
DAEG+ ++G+ L +RY + G+G F VV+ D+ R VA+KII+N E ++
Sbjct: 145 DAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAA 204
Query: 730 LKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHI 789
E+ L+K+N+ DPD+K C+++F F + H+C+ FE L ++ + LK + I
Sbjct: 205 RLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKD-NNYLPYPI 263
Query: 790 KAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNES------------------KTILK 831
VR + QL A+K L + H D+KP+NIL S T ++
Sbjct: 264 HQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVR 323
Query: 832 LCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPG 891
+ DFGSA+ ++ T + +R YRAPE+I+ + D+WS+GC ++E Y G LF
Sbjct: 324 VVDFGSATFDHEHHST-IVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQT 382
Query: 892 KTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINP 951
N L + + G +P++MIRK K ++F + ++ D+ T + V P
Sbjct: 383 HDNREHLAMMERILGPIPSRMIRK-TRKQKYFYRG----RLDWDENTSAGRY-VRENCKP 436
Query: 952 TKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAF 1002
+ L + ++ HQL DL++ +L +PAKR+++ +ALQH F
Sbjct: 437 LRRYLT----------SEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPF 477
Score = 40.8 bits (94), Expect = 0.006
Identities = 51/162 (31%), Positives = 64/162 (39%), Gaps = 23/162 (14%)
Query: 357 PKPRDKSRRSRSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRP 416
P PR R + R +S+ R S R+ S S +R RR RRR S R
Sbjct: 2 PHPRRYHSSERGSRGSYREHYRSRKHKRRRS---RSWSSSSDRTRR---RRREDSYHVRS 55
Query: 417 RDDILSRRERSKDASPINR----------WSPTRRRSRSPIRRRSRSPLRRSRSPRRRSR 466
R S +RS D +R +S R + R +R S R R
Sbjct: 56 RS---SYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQR 112
Query: 467 SPRRRDRGRRSRSRLRRRSRSRGGRRRRSRSKVKEDKFKGSL 508
S RR+ R RR RSR RS S RR +S ED +G L
Sbjct: 113 SSRRKHRRRRRRSRTFSRSSSHSSRRAKS----VEDDAEGHL 150
Score = 32.3 bits (72), Expect = 2.3
Identities = 37/148 (25%), Positives = 62/148 (41%), Gaps = 16/148 (10%)
Query: 193 RHRSDKKKSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLRRRSQEKI 252
R+ S ++ S+G + RS+ +R++S+S S S D+ R+ RRR
Sbjct: 6 RYHSSERGSRGSYR----EHYRSRKHKRRRSRS---WSSSSDRTRR------RRREDSYH 52
Query: 253 GKARSPTDDKVKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSKER 312
++RS DD + D+ R SRDRG + D R + +R S R
Sbjct: 53 VRSRSSYDD--RSSDRRVYDRRYCGSYRRNDYSRDRG-DAYYDTDYRHSYEYQRENSSYR 109
Query: 313 KSKRSETDKEKKPIKSPSKDASSGKENR 340
+ S ++ +S + SS +R
Sbjct: 110 SQRSSRRKHRRRRRRSRTFSRSSSHSSR 137
Score = 32.0 bits (71), Expect = 3.0
Identities = 39/129 (30%), Positives = 49/129 (37%), Gaps = 2/129 (1%)
Query: 391 RAKSRSLERKRREPERRRLSSPRTRPRDDILSRRERSKDASPINRWSPTRRRSRSPIRRR 450
R RS + KRR SS RTR R S RS+ +S +R S R R
Sbjct: 19 REHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSR-SSYDDRSSDRRVYDRRYCGSY 77
Query: 451 SRSPLRRSRSPRRRSRSPRRRDRGRRSRSRLR-RRSRSRGGRRRRSRSKVKEDKFKGSLS 509
R+ R R R +R S R +RS R RRRR RS+ S
Sbjct: 78 RRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSHSSR 137
Query: 510 EGMKVEQES 518
VE ++
Sbjct: 138 RAKSVEDDA 146
>gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 5 [Homo sapiens]
Length = 529
Score = 169 bits (429), Expect = 9e-42
Identities = 123/374 (32%), Positives = 191/374 (51%), Gaps = 15/374 (4%)
Query: 643 YFDSARLRAAGIGKDF---KENPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFS 699
Y R G G D KE D + D Y V GE RY + G+G F
Sbjct: 112 YAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFG 171
Query: 700 NVVRARDNARANQE-VAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFY 758
VV+A D R QE VA+KII+N + E+ L+ +N D + K++ + L RHF
Sbjct: 172 QVVKAYD--RVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFM 229
Query: 759 HKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLK--RCNILHADI 816
+ HLCLVFE LS NL ++L+ G+ + R ++QQ+ AL L +I+H D+
Sbjct: 230 FRNHLCLVFEMLSYNLYDLLRNTNFR-GVSLNLTRKFAQQMCTALLFLATPELSIIHCDL 288
Query: 817 KPDNILV-NESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSV 875
KP+NIL+ N ++ +K+ DFGS+ + I Y+ SRFYR+PE+++G YD IDMWS+
Sbjct: 289 KPENILLCNPKRSAIKIVDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGMPYDLAIDMWSL 347
Query: 876 GCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMY-IEV 934
GC L E++TG+ LF G + +++ G P ++ + + F++ + + ++
Sbjct: 348 GCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKK 407
Query: 935 DKVTERE-KVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQL--KDLLDQILMLDPAKR 991
K +RE K ++ + G +R E L KDL+ ++L DP R
Sbjct: 408 TKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTR 467
Query: 992 ISINQALQHAFIQE 1005
I ALQH+F ++
Sbjct: 468 IQPYYALQHSFFKK 481
>gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 4 [Homo sapiens]
Length = 540
Score = 169 bits (429), Expect = 9e-42
Identities = 123/374 (32%), Positives = 191/374 (51%), Gaps = 15/374 (4%)
Query: 643 YFDSARLRAAGIGKDF---KENPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFS 699
Y R G G D KE D + D Y V GE RY + G+G F
Sbjct: 112 YAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFG 171
Query: 700 NVVRARDNARANQE-VAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFY 758
VV+A D R QE VA+KII+N + E+ L+ +N D + K++ + L RHF
Sbjct: 172 QVVKAYD--RVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFM 229
Query: 759 HKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLK--RCNILHADI 816
+ HLCLVFE LS NL ++L+ G+ + R ++QQ+ AL L +I+H D+
Sbjct: 230 FRNHLCLVFEMLSYNLYDLLRNTNFR-GVSLNLTRKFAQQMCTALLFLATPELSIIHCDL 288
Query: 817 KPDNILV-NESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSV 875
KP+NIL+ N ++ +K+ DFGS+ + I Y+ SRFYR+PE+++G YD IDMWS+
Sbjct: 289 KPENILLCNPKRSAIKIVDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGMPYDLAIDMWSL 347
Query: 876 GCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMY-IEV 934
GC L E++TG+ LF G + +++ G P ++ + + F++ + + ++
Sbjct: 348 GCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKK 407
Query: 935 DKVTERE-KVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQL--KDLLDQILMLDPAKR 991
K +RE K ++ + G +R E L KDL+ ++L DP R
Sbjct: 408 TKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTR 467
Query: 992 ISINQALQHAFIQE 1005
I ALQH+F ++
Sbjct: 468 IQPYYALQHSFFKK 481
>gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 3 [Homo sapiens]
Length = 584
Score = 169 bits (429), Expect = 9e-42
Identities = 123/374 (32%), Positives = 191/374 (51%), Gaps = 15/374 (4%)
Query: 643 YFDSARLRAAGIGKDF---KENPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFS 699
Y R G G D KE D + D Y V GE RY + G+G F
Sbjct: 112 YAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFG 171
Query: 700 NVVRARDNARANQE-VAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFY 758
VV+A D R QE VA+KII+N + E+ L+ +N D + K++ + L RHF
Sbjct: 172 QVVKAYD--RVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFM 229
Query: 759 HKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLK--RCNILHADI 816
+ HLCLVFE LS NL ++L+ G+ + R ++QQ+ AL L +I+H D+
Sbjct: 230 FRNHLCLVFEMLSYNLYDLLRNTNFR-GVSLNLTRKFAQQMCTALLFLATPELSIIHCDL 288
Query: 817 KPDNILV-NESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSV 875
KP+NIL+ N ++ +K+ DFGS+ + I Y+ SRFYR+PE+++G YD IDMWS+
Sbjct: 289 KPENILLCNPKRSAIKIVDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGMPYDLAIDMWSL 347
Query: 876 GCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMY-IEV 934
GC L E++TG+ LF G + +++ G P ++ + + F++ + + ++
Sbjct: 348 GCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKK 407
Query: 935 DKVTERE-KVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQL--KDLLDQILMLDPAKR 991
K +RE K ++ + G +R E L KDL+ ++L DP R
Sbjct: 408 TKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTR 467
Query: 992 ISINQALQHAFIQE 1005
I ALQH+F ++
Sbjct: 468 IQPYYALQHSFFKK 481
>gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 2 [Homo sapiens]
Length = 754
Score = 169 bits (429), Expect = 9e-42
Identities = 123/374 (32%), Positives = 191/374 (51%), Gaps = 15/374 (4%)
Query: 643 YFDSARLRAAGIGKDF---KENPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFS 699
Y R G G D KE D + D Y V GE RY + G+G F
Sbjct: 103 YAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFG 162
Query: 700 NVVRARDNARANQE-VAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFY 758
VV+A D R QE VA+KII+N + E+ L+ +N D + K++ + L RHF
Sbjct: 163 QVVKAYD--RVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFM 220
Query: 759 HKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLK--RCNILHADI 816
+ HLCLVFE LS NL ++L+ G+ + R ++QQ+ AL L +I+H D+
Sbjct: 221 FRNHLCLVFEMLSYNLYDLLRNTNFR-GVSLNLTRKFAQQMCTALLFLATPELSIIHCDL 279
Query: 817 KPDNILV-NESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSV 875
KP+NIL+ N ++ +K+ DFGS+ + I Y+ SRFYR+PE+++G YD IDMWS+
Sbjct: 280 KPENILLCNPKRSAIKIVDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGMPYDLAIDMWSL 338
Query: 876 GCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMY-IEV 934
GC L E++TG+ LF G + +++ G P ++ + + F++ + + ++
Sbjct: 339 GCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKK 398
Query: 935 DKVTERE-KVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQL--KDLLDQILMLDPAKR 991
K +RE K ++ + G +R E L KDL+ ++L DP R
Sbjct: 399 TKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTR 458
Query: 992 ISINQALQHAFIQE 1005
I ALQH+F ++
Sbjct: 459 IQPYYALQHSFFKK 472
>gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 1 [Homo sapiens]
Length = 763
Score = 169 bits (429), Expect = 9e-42
Identities = 123/374 (32%), Positives = 191/374 (51%), Gaps = 15/374 (4%)
Query: 643 YFDSARLRAAGIGKDF---KENPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFS 699
Y R G G D KE D + D Y V GE RY + G+G F
Sbjct: 112 YAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFG 171
Query: 700 NVVRARDNARANQE-VAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFY 758
VV+A D R QE VA+KII+N + E+ L+ +N D + K++ + L RHF
Sbjct: 172 QVVKAYD--RVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFM 229
Query: 759 HKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLK--RCNILHADI 816
+ HLCLVFE LS NL ++L+ G+ + R ++QQ+ AL L +I+H D+
Sbjct: 230 FRNHLCLVFEMLSYNLYDLLRNTNFR-GVSLNLTRKFAQQMCTALLFLATPELSIIHCDL 288
Query: 817 KPDNILV-NESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSV 875
KP+NIL+ N ++ +K+ DFGS+ + I Y+ SRFYR+PE+++G YD IDMWS+
Sbjct: 289 KPENILLCNPKRSAIKIVDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGMPYDLAIDMWSL 347
Query: 876 GCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMY-IEV 934
GC L E++TG+ LF G + +++ G P ++ + + F++ + + ++
Sbjct: 348 GCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKK 407
Query: 935 DKVTERE-KVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQL--KDLLDQILMLDPAKR 991
K +RE K ++ + G +R E L KDL+ ++L DP R
Sbjct: 408 TKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTR 467
Query: 992 ISINQALQHAFIQE 1005
I ALQH+F ++
Sbjct: 468 IQPYYALQHSFFKK 481
>gi|164420691 homeodomain interacting protein kinase 2 isoform 2 [Homo
sapiens]
Length = 1171
Score = 169 bits (427), Expect = 2e-41
Identities = 117/359 (32%), Positives = 189/359 (52%), Gaps = 25/359 (6%)
Query: 665 RDNWTDAEGYYRVNIGEVL---DKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRN 721
+++ +++EG Y++ EVL Y V + G+G F VV+ N+ VA+KI++N
Sbjct: 174 KNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRG-TNEIVAIKILKN 232
Query: 722 NELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKY 781
+ + G E+ L +L+ DD ++ +R + F HK H CLVFE L NL + LK+
Sbjct: 233 HPSYARQGQIEVSILARLSTESADD-YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQ- 290
Query: 782 GKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNI-LVNESKTI--LKLCDFGSA 838
K L +K +R QQ+ AL LK ++HAD+KP+NI LV+ S+ +K+ DFGSA
Sbjct: 291 NKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSA 350
Query: 839 SHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHML 898
SHV+ + YL SR+YRAPEII+G + IDMWS+GC + EL+ G L+PG + +
Sbjct: 351 SHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQI 410
Query: 899 KLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMY--IEVDKVTEREKVTVMSTINPTK--- 953
+ +G ++ G + F+++ + Y + + E T + + K
Sbjct: 411 RYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIF 470
Query: 954 ---------DLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFI 1003
++ DL G L E ++ + DLL ++L +D KRI+ + L H F+
Sbjct: 471 NCLDDMAQVNMTTDLEGSDMLVEKADRR--EFIDLLKKMLTIDADKRITPIETLNHPFV 527
>gi|164420685 homeodomain interacting protein kinase 2 isoform 1 [Homo
sapiens]
Length = 1198
Score = 169 bits (427), Expect = 2e-41
Identities = 117/359 (32%), Positives = 189/359 (52%), Gaps = 25/359 (6%)
Query: 665 RDNWTDAEGYYRVNIGEVL---DKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRN 721
+++ +++EG Y++ EVL Y V + G+G F VV+ N+ VA+KI++N
Sbjct: 174 KNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRG-TNEIVAIKILKN 232
Query: 722 NELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKY 781
+ + G E+ L +L+ DD ++ +R + F HK H CLVFE L NL + LK+
Sbjct: 233 HPSYARQGQIEVSILARLSTESADD-YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQ- 290
Query: 782 GKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNI-LVNESKTI--LKLCDFGSA 838
K L +K +R QQ+ AL LK ++HAD+KP+NI LV+ S+ +K+ DFGSA
Sbjct: 291 NKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSA 350
Query: 839 SHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHML 898
SHV+ + YL SR+YRAPEII+G + IDMWS+GC + EL+ G L+PG + +
Sbjct: 351 SHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQI 410
Query: 899 KLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMY--IEVDKVTEREKVTVMSTINPTK--- 953
+ +G ++ G + F+++ + Y + + E T + + K
Sbjct: 411 RYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIF 470
Query: 954 ---------DLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFI 1003
++ DL G L E ++ + DLL ++L +D KRI+ + L H F+
Sbjct: 471 NCLDDMAQVNMTTDLEGSDMLVEKADRR--EFIDLLKKMLTIDADKRITPIETLNHPFV 527
>gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform b [Homo sapiens]
Length = 589
Score = 169 bits (427), Expect = 2e-41
Identities = 115/349 (32%), Positives = 177/349 (50%), Gaps = 42/349 (12%)
Query: 659 KENPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKI 718
KE L + D Y V GE +RY + G+G F VV+A D+ + + VA+KI
Sbjct: 83 KEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDH-QTQELVAIKI 141
Query: 719 IRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVL 778
I+N + EL L+ +N D + K++ + L RHF + HLCLVFE LS NL ++L
Sbjct: 142 IKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLL 201
Query: 779 KKYGKDVGLHIKAVRSYSQQLFLALKLLK--RCNILHADIKPDNILV-NESKTILKLCDF 835
+ G+ + R +QQL AL L +I+H D+KP+NIL+ N ++ +K+ DF
Sbjct: 202 RNTHFR-GVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF 260
Query: 836 GSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNN 895
GS+ + I Y+ SRFYR+PE+++G YD IDMWS+GC L E++TG+ LF G
Sbjct: 261 GSSCQLGQR-IYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEV 319
Query: 896 HMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDL 955
+ +++ G P M+ + ++F++ + T+ TK+L
Sbjct: 320 DQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGW----------------TLRRTKEL 363
Query: 956 LADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQ 1004
KDL+ ++L +PA RIS ALQH F +
Sbjct: 364 --------------------RKDLVLRMLEYEPAARISPLGALQHGFFR 392
>gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 4 [Homo sapiens]
Length = 520
Score = 166 bits (419), Expect = 1e-40
Identities = 106/347 (30%), Positives = 176/347 (50%), Gaps = 32/347 (9%)
Query: 665 RDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNEL 724
+ ++ D G+Y + + + RY V G+G F V + D+ + N+ VA+KIIRN +
Sbjct: 82 KTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDH-KNNELVALKIIRNKKR 140
Query: 725 MQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKD 784
+ L EL+ L+ L D D+ ++ + + FY + H C+ FE L +NL E++K
Sbjct: 141 FHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQ 200
Query: 785 VGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNI-LVNESKTILKLCDFGSASHVAD 843
G + VR ++ + L++L I+H D+KP+NI L + + +K+ DFGS+ +
Sbjct: 201 -GFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQASVKVIDFGSSCYEHQ 259
Query: 844 NDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMD 903
T Y+ SRFYR+PE+I+G YD IDMWS+GC ELYTG LFPG+ L M+
Sbjct: 260 KVYT-YIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACIME 318
Query: 904 LKGKMPNKMI-----RKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLAD 958
+ G P I R+ F + F +N+ + ++ V+ T + +
Sbjct: 319 VLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSKDLTMVLKTYDTS------ 372
Query: 959 LIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQE 1005
D L + L+ +P+ R++ +QAL+HA+I +
Sbjct: 373 -----------------FLDFLRRCLVWEPSLRMTPDQALKHAWIHQ 402
>gi|38201640 homeodomain-interacting protein kinase 1 isoform 1 [Homo
sapiens]
Length = 1210
Score = 165 bits (418), Expect = 2e-40
Identities = 115/357 (32%), Positives = 183/357 (51%), Gaps = 29/357 (8%)
Query: 669 TDAEGYYRVNIGEVL---DKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELM 725
+ EG Y++ E+L Y V + G+G F V + + + VA+KI++N+
Sbjct: 169 SSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRS-TKEIVAIKILKNHPSY 227
Query: 726 QKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDV 785
+ G E+ L +L+ + D+ ++ +R + F HK H CLVFE L NL + LK+ K
Sbjct: 228 ARQGQIEVSILSRLSSENADE-YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFS 285
Query: 786 GLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNE---SKTILKLCDFGSASHVA 842
L +K +R QQ+ AL LK ++HAD+KP+NI++ + +K+ DFGSASHV+
Sbjct: 286 PLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVS 345
Query: 843 DNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAM 902
+ YL SR+YRAPEII+G + IDMWS+GC + EL+ G L+PG + ++
Sbjct: 346 KAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYIS 405
Query: 903 DLKGKMPNKMIRKGVFKDQHF--DQNLNFMYIEVDKVTEREKVTVMSTINPTK------- 953
+G ++ G + F D NL + + E E T + + K
Sbjct: 406 QTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLD 465
Query: 954 -----DLLADLIGCQRLPE--DQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFI 1003
++ DL G L E D+R+ + DLL ++L +D KRI+ + L H F+
Sbjct: 466 DMAQVNMSTDLEGTDMLAEKADRREYI----DLLKKMLTIDADKRITPLKTLNHQFV 518
>gi|38201638 homeodomain-interacting protein kinase 1 isoform 2 [Homo
sapiens]
Length = 1075
Score = 165 bits (418), Expect = 2e-40
Identities = 115/357 (32%), Positives = 183/357 (51%), Gaps = 29/357 (8%)
Query: 669 TDAEGYYRVNIGEVL---DKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELM 725
+ EG Y++ E+L Y V + G+G F V + + + VA+KI++N+
Sbjct: 169 SSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRS-TKEIVAIKILKNHPSY 227
Query: 726 QKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDV 785
+ G E+ L +L+ + D+ ++ +R + F HK H CLVFE L NL + LK+ K
Sbjct: 228 ARQGQIEVSILSRLSSENADE-YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFS 285
Query: 786 GLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNE---SKTILKLCDFGSASHVA 842
L +K +R QQ+ AL LK ++HAD+KP+NI++ + +K+ DFGSASHV+
Sbjct: 286 PLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVS 345
Query: 843 DNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAM 902
+ YL SR+YRAPEII+G + IDMWS+GC + EL+ G L+PG + ++
Sbjct: 346 KAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYIS 405
Query: 903 DLKGKMPNKMIRKGVFKDQHF--DQNLNFMYIEVDKVTEREKVTVMSTINPTK------- 953
+G ++ G + F D NL + + E E T + + K
Sbjct: 406 QTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLD 465
Query: 954 -----DLLADLIGCQRLPE--DQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFI 1003
++ DL G L E D+R+ + DLL ++L +D KRI+ + L H F+
Sbjct: 466 DMAQVNMSTDLEGTDMLAEKADRREYI----DLLKKMLTIDADKRITPLKTLNHQFV 518
>gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform b [Homo sapiens]
Length = 568
Score = 162 bits (409), Expect = 2e-39
Identities = 109/349 (31%), Positives = 171/349 (48%), Gaps = 21/349 (6%)
Query: 668 WTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQK 727
+ DA+G Y + L RY V G+G F V R D+ + Q VA+K++RN + +
Sbjct: 170 YDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDH-KLRQYVALKMVRNEKRFHR 228
Query: 728 TGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGL 787
+E+ L+ L D + + + F + H+C+ FE LS++L E++KK K G
Sbjct: 229 QAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKK-NKFQGF 287
Query: 788 HIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILV-NESKTILKLCDFGSASHVADNDI 846
++ VR ++Q + +L L + I+H D+KP+NIL+ + ++ K+ DFGS+
Sbjct: 288 SVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLY 347
Query: 847 TPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKG 906
T Y+ SRFYRAPEII+G Y ID+WS GC L EL TG+ LFPG+ L M+L G
Sbjct: 348 T-YIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLG 406
Query: 907 KMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTIN--------PTKDLLAD 958
P K++ + + Y V + V V +KD
Sbjct: 407 MPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTA 466
Query: 959 LIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQEKI 1007
L GC + + L + L DP+ R++ QAL+H +I + +
Sbjct: 467 LKGCDD---------YLFIEFLKRCLHWDPSARLTPAQALRHPWISKSV 506
>gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform a [Homo sapiens]
Length = 588
Score = 162 bits (409), Expect = 2e-39
Identities = 109/349 (31%), Positives = 171/349 (48%), Gaps = 21/349 (6%)
Query: 668 WTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQK 727
+ DA+G Y + L RY V G+G F V R D+ + Q VA+K++RN + +
Sbjct: 190 YDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDH-KLRQYVALKMVRNEKRFHR 248
Query: 728 TGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGL 787
+E+ L+ L D + + + F + H+C+ FE LS++L E++KK K G
Sbjct: 249 QAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKK-NKFQGF 307
Query: 788 HIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILV-NESKTILKLCDFGSASHVADNDI 846
++ VR ++Q + +L L + I+H D+KP+NIL+ + ++ K+ DFGS+
Sbjct: 308 SVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLY 367
Query: 847 TPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKG 906
T Y+ SRFYRAPEII+G Y ID+WS GC L EL TG+ LFPG+ L M+L G
Sbjct: 368 T-YIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLG 426
Query: 907 KMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTIN--------PTKDLLAD 958
P K++ + + Y V + V V +KD
Sbjct: 427 MPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTA 486
Query: 959 LIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQEKI 1007
L GC + + L + L DP+ R++ QAL+H +I + +
Sbjct: 487 LKGCDD---------YLFIEFLKRCLHWDPSARLTPAQALRHPWISKSV 526
>gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens]
Length = 526
Score = 159 bits (402), Expect = 1e-38
Identities = 105/352 (29%), Positives = 178/352 (50%), Gaps = 38/352 (10%)
Query: 670 DAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTG 729
D EG+ G+VL RY + G+G F VV D+ + VAVKI++N + +
Sbjct: 186 DEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAA 245
Query: 730 LKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHI 789
E++ L+ LN DP+ F C+++ F H H+C+VFE L ++ + +K+ G + +
Sbjct: 246 RSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENG-FLPFRL 304
Query: 790 KAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNES--------------KTI----LK 831
+R + Q+ ++ L + H D+KP+NIL +S +T+ +K
Sbjct: 305 DHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIK 364
Query: 832 LCDFGSASHVADNDITPYLVS-RFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFP 890
+ DFGSA++ D++ LVS R YRAPE+I+ + D+WS+GC L E Y G +FP
Sbjct: 365 VVDFGSATY--DDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFP 422
Query: 891 GKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTIN 950
+ L + + G +P MI+K K ++F + ++ D+ + + V
Sbjct: 423 THDSKEHLAMMERILGPLPKHMIQK-TRKRKYFHHD----RLDWDEHSSAGRY-VSRRCK 476
Query: 951 PTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAF 1002
P K+ + Q + +L DL+ ++L DPAKRI++ +AL+H F
Sbjct: 477 PLKEFML----------SQDVEHERLFDLIQKMLEYDPAKRITLREALKHPF 518
>gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]
Length = 484
Score = 159 bits (402), Expect = 1e-38
Identities = 105/352 (29%), Positives = 178/352 (50%), Gaps = 38/352 (10%)
Query: 670 DAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTG 729
D EG+ G+VL RY + G+G F VV D+ + VAVKI++N + +
Sbjct: 144 DEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAA 203
Query: 730 LKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHI 789
E++ L+ LN DP+ F C+++ F H H+C+VFE L ++ + +K+ G + +
Sbjct: 204 RSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENG-FLPFRL 262
Query: 790 KAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNES--------------KTI----LK 831
+R + Q+ ++ L + H D+KP+NIL +S +T+ +K
Sbjct: 263 DHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIK 322
Query: 832 LCDFGSASHVADNDITPYLVS-RFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFP 890
+ DFGSA++ D++ LVS R YRAPE+I+ + D+WS+GC L E Y G +FP
Sbjct: 323 VVDFGSATY--DDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFP 380
Query: 891 GKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTIN 950
+ L + + G +P MI+K K ++F + ++ D+ + + V
Sbjct: 381 THDSKEHLAMMERILGPLPKHMIQK-TRKRKYFHHD----RLDWDEHSSAGRY-VSRRCK 434
Query: 951 PTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAF 1002
P K+ + Q + +L DL+ ++L DPAKRI++ +AL+H F
Sbjct: 435 PLKEFML----------SQDVEHERLFDLIQKMLEYDPAKRITLREALKHPF 476
>gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens]
Length = 638
Score = 155 bits (391), Expect = 2e-37
Identities = 110/351 (31%), Positives = 170/351 (48%), Gaps = 36/351 (10%)
Query: 670 DAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTG 729
D EG+ IG+ L +RY + G G+G F VV D+AR +VA+KIIRN ++
Sbjct: 287 DKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAA 346
Query: 730 LKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHI 789
E+ LKK+ + D ++KF C+ + F H+C+ FE L N E LK+ +
Sbjct: 347 RLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKE-NNFQPYPL 405
Query: 790 KAVRSYSQQLFLALKLLKRCNILHADIKPDNI---------LVNESK---------TILK 831
VR + QL AL+ L + H D+KP+NI L NE K T ++
Sbjct: 406 PHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIR 465
Query: 832 LCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPG 891
+ DFGSA+ ++ T + +R YR PE+I+ + D+WS+GC L+E Y G LF
Sbjct: 466 VADFGSATFDHEHH-TTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQT 524
Query: 892 KTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINP 951
N L + + G +P+ MI + + Q + ++ E + V P
Sbjct: 525 HENREHLVMMEKILGPIPSHMIHR--TRKQKYFYKGGLVWDE----NSSDGRYVKENCKP 578
Query: 952 TKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAF 1002
K + +D + V QL DL+ ++L DPA+RI++ +AL H F
Sbjct: 579 LKSYML---------QDSLEHV-QLFDLMRRMLEFDPAQRITLAEALLHPF 619
Score = 44.3 bits (103), Expect = 6e-04
Identities = 59/214 (27%), Positives = 85/214 (39%), Gaps = 29/214 (13%)
Query: 301 KSKDRRSRSKERKSKRSETDKEKKPIKSPSKDASSGKENRSPSRRPGRSP---------- 350
+S R +R R R T ++ P + ++G + S G +
Sbjct: 93 ESGARAARPPSRVEPRLATAASREGAGLPRAEVAAGSGRGARSGEWGLAAAGAWETMHHC 152
Query: 351 -KRRSLSPKPRDKSRRSRSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRL 409
+ RS P P R R + + + PSR P RR++SRS +R P +RR
Sbjct: 153 KRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRL---PYQRRY 209
Query: 410 SSPRTRPRDDILSRRERSKDASPINRWSPTRRRSRSPIRRRSRSPLRRSRSPRRRSRSPR 469
R R D ERS + + P+R R R R R R P R+R
Sbjct: 210 ---RERRDSDTYRCEERSPSFGE-DYYGPSRSRHRR--RSRERGPY--------RTRKHA 255
Query: 470 RRDRGRRSRSRLRRRSRSRGGRRRRSRSKVKEDK 503
RR+RS SRS+ +R SRS V++DK
Sbjct: 256 HHCHKRRTRSCSSASSRSQQSSKRSSRS-VEDDK 288
Score = 42.4 bits (98), Expect = 0.002
Identities = 45/144 (31%), Positives = 57/144 (39%), Gaps = 15/144 (10%)
Query: 407 RRLSSPRTRPRDDILSRRERSKDASPINRWSPTRRRSRSPIRRRSRS----PLRRSRSPR 462
+R SP P +R RS R RR P R RSRS P +R R
Sbjct: 153 KRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRER 212
Query: 463 RRSRSPRRRDRGRR--------SRSRLRRRSRSRGGRRRRSRSKVKEDKFKGSLSEGMKV 514
R S + R +R SRSR RRRSR RG R R + + S S
Sbjct: 213 RDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSR 272
Query: 515 EQESSSDDNLEDFDVEEEDEEALI 538
Q+SS + VE++ E L+
Sbjct: 273 SQQSSKRSSR---SVEDDKEGHLV 293
>gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens]
Length = 490
Score = 155 bits (391), Expect = 2e-37
Identities = 110/351 (31%), Positives = 170/351 (48%), Gaps = 36/351 (10%)
Query: 670 DAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTG 729
D EG+ IG+ L +RY + G G+G F VV D+AR +VA+KIIRN ++
Sbjct: 139 DKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAA 198
Query: 730 LKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHI 789
E+ LKK+ + D ++KF C+ + F H+C+ FE L N E LK+ +
Sbjct: 199 RLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKE-NNFQPYPL 257
Query: 790 KAVRSYSQQLFLALKLLKRCNILHADIKPDNI---------LVNESK---------TILK 831
VR + QL AL+ L + H D+KP+NI L NE K T ++
Sbjct: 258 PHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIR 317
Query: 832 LCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPG 891
+ DFGSA+ ++ T + +R YR PE+I+ + D+WS+GC L+E Y G LF
Sbjct: 318 VADFGSATFDHEHH-TTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQT 376
Query: 892 KTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINP 951
N L + + G +P+ MI + + Q + ++ E + V P
Sbjct: 377 HENREHLVMMEKILGPIPSHMIHR--TRKQKYFYKGGLVWDE----NSSDGRYVKENCKP 430
Query: 952 TKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAF 1002
K + +D + V QL DL+ ++L DPA+RI++ +AL H F
Sbjct: 431 LKSYML---------QDSLEHV-QLFDLMRRMLEFDPAQRITLAEALLHPF 471
Score = 43.9 bits (102), Expect = 8e-04
Identities = 49/151 (32%), Positives = 65/151 (43%), Gaps = 18/151 (11%)
Query: 353 RSLSPKPRDKSRRSRSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSP 412
RS P P R R + + + PSR P RR++SRS +R P +RR
Sbjct: 8 RSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRL---PYQRRY--- 61
Query: 413 RTRPRDDILSRRERSKDASPINRWSPTRRRSRSPIRRRSRSPLRRSRSPRRRSRSPRRRD 472
R R D ERS + + P+R R R R R R P R+R
Sbjct: 62 RERRDSDTYRCEERSPSFGE-DYYGPSRSRHRR--RSRERGPY--------RTRKHAHHC 110
Query: 473 RGRRSRSRLRRRSRSRGGRRRRSRSKVKEDK 503
RR+RS SRS+ +R SRS V++DK
Sbjct: 111 HKRRTRSCSSASSRSQQSSKRSSRS-VEDDK 140
Score = 42.4 bits (98), Expect = 0.002
Identities = 45/144 (31%), Positives = 57/144 (39%), Gaps = 15/144 (10%)
Query: 407 RRLSSPRTRPRDDILSRRERSKDASPINRWSPTRRRSRSPIRRRSRS----PLRRSRSPR 462
+R SP P +R RS R RR P R RSRS P +R R
Sbjct: 5 KRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRER 64
Query: 463 RRSRSPRRRDRGRR--------SRSRLRRRSRSRGGRRRRSRSKVKEDKFKGSLSEGMKV 514
R S + R +R SRSR RRRSR RG R R + + S S
Sbjct: 65 RDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSR 124
Query: 515 EQESSSDDNLEDFDVEEEDEEALI 538
Q+SS + VE++ E L+
Sbjct: 125 SQQSSKRSSR---SVEDDKEGHLV 145
>gi|10190706 CDC-like kinase 4 [Homo sapiens]
Length = 481
Score = 154 bits (390), Expect = 3e-37
Identities = 105/352 (29%), Positives = 175/352 (49%), Gaps = 38/352 (10%)
Query: 670 DAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTG 729
D EG+ G+VL RY + G+G F VV D+ VAVKI++N ++
Sbjct: 142 DEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAA 201
Query: 730 LKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHI 789
E++ L+ LN DP+ F C+++ F H H+C+VFE L ++ + +K+ + I
Sbjct: 202 RSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKE-NSFLPFQI 260
Query: 790 KAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNES------------------KTILK 831
+R + Q+ ++ L + H D+KP+NIL +S T +K
Sbjct: 261 DHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIK 320
Query: 832 LCDFGSASHVADNDITPYLVS-RFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFP 890
+ DFGSA++ D++ LVS R YRAPE+I+ + D+WS+GC L E Y G +F
Sbjct: 321 VVDFGSATY--DDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQ 378
Query: 891 GKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTIN 950
+ L + + G +P MI+K K ++F N ++ D+ + + V
Sbjct: 379 THDSKEHLAMMERILGPIPQHMIQK-TRKRKYFHHN----QLDWDEHSSAGRY-VRRRCK 432
Query: 951 PTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAF 1002
P K+ + L D+ + +L DL+ ++L DP +RI++++ALQH F
Sbjct: 433 PLKEFM--------LCHDEEHE--KLFDLVRRMLEYDPTQRITLDEALQHPF 474
Score = 32.3 bits (72), Expect = 2.3
Identities = 41/160 (25%), Positives = 63/160 (39%), Gaps = 25/160 (15%)
Query: 53 KHKKHKHSSEEDKDKKHKHKHKHKKHKRKEIIDASDKEG--MSPAKRTKLDDLALLE--- 107
+H K H + D + H+ HKRK +S +E P + K D LE
Sbjct: 2 RHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARS 61
Query: 108 ----DLEKQRALIKAELDNELMEGKVQSGMGLILQGYESGSEEEGEIHEKARNGNRSSTR 163
D +R + E N+ EG V + Y E IH ++SS R
Sbjct: 62 LNERDYRDRRYV--DEYRNDYCEGYVP-------RHYHRDIESGYRIH-----CSKSSVR 107
Query: 164 SSSTKGKLELVDNKITTKKRSKSRSKERTRHRSDKKKSKG 203
S + K + N+ + +S+S+S R R RS + +G
Sbjct: 108 SRRSSPKRK--RNRHCSSHQSRSKSHRRKRSRSIEDDEEG 145
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 145 bits (367), Expect = 1e-34
Identities = 162/543 (29%), Positives = 230/543 (42%), Gaps = 69/543 (12%)
Query: 5 ETQSLREQPEMEDANSEKSINEENGEVSEDQSQNKHSRHKKKKHKHRSKHKKHKHSSEED 64
E+ S R + +K E S + + K S KKKKH+ S+ KK KH S
Sbjct: 176 ESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSS-KKKKHRSESESKKRKHRSPTP 234
Query: 65 KDKKHKHKHKHKKHKRKEIIDASDKEGMSPAKRTKLDDLALLEDLEKQRAL-IKAELDNE 123
K K+ K K KK KR + K A R+ D A D + R+ A+
Sbjct: 235 KSKR---KSKDKKRKRSRSTTPAPKSRR--AHRSTSADSASSSDTSRSRSRSAAAKTHTT 289
Query: 124 LMEGKVQSGMGLILQGYESGSEEEGEIHEKARNGNRSSTRSSSTKGKLELVDNKITTKKR 183
+ G+ S SG EG+ + G S+ R SS + + + K +
Sbjct: 290 ALAGRSPSPA--------SGRRGEGDA-PFSEPGTTSTQRPSSPETATKQPSSPYEDKDK 340
Query: 184 SKSRSKERTRHRSDKKKSKGGIE------IVKEKTTRSKSK------ERKKSKSPSKRSK 231
K + K TR ++S G E ++ E+ S ++ PS+ S
Sbjct: 341 DK-KEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASP 399
Query: 232 SQDQARKSKSPTLRRRSQEKIGKARSPTDDKVKIEDKSKSKDRKKSPI-----------I 280
++D++ KSP +S SP KV S + K +P
Sbjct: 400 TRDRS-PPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPT 458
Query: 281 NESRSRDRGKKSRS----PVDLRGKSKD----RRSRSKERKSKRSETDKEKKPIKSPSKD 332
+++RS R K+ +S P G+S+ +R RS+ R + + + P S+
Sbjct: 459 SKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRS 518
Query: 333 ASSGKENRSPSRRP-GRSPKRRSLSPKPRDKSRRSRSPLLNDRRSKQSKSP-----SRTL 386
A +RSP RR RSP+R S + R+ RR RS RS S+SP SR+
Sbjct: 519 AQRWGRSRSPQRRGRSRSPQRPGWS-RSRNTQRRGRSRSARRGRS-HSRSPATRGRSRSR 576
Query: 387 SPGRRAKSRSLERKRREPERRRLSS---PRTRPRDDILSRRERSKDASPINRWSPTRRRS 443
+P RR +SRS R P RRR S R R R +RR RS+ +P R R R+
Sbjct: 577 TPARRGRSRS-----RTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARR----RSRT 627
Query: 444 RSPIRRRSRSPLRRSRSPRRRSRSPRRRDRGRRSRSRLRRRSRSRGGRRRRSRSKVKEDK 503
RSP+RRRSRS RS R RSR+P RR R R R RSRSR RR RS+ +
Sbjct: 628 RSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSGRSRSRTPA 687
Query: 504 FKG 506
+G
Sbjct: 688 RRG 690
Score = 124 bits (311), Expect = 4e-28
Identities = 169/572 (29%), Positives = 244/572 (42%), Gaps = 87/572 (15%)
Query: 18 ANSEKSINEENGEVSEDQSQNKHSRHKKKKHKHRSKHKKHKHSSEEDKDKKHKHKHKHKK 77
+ S + ++ + +++S++ S K K + + + SS E K + +
Sbjct: 1539 SGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRS 1598
Query: 78 HKRKEIIDASDKEGMSPAKRTKLDDLALLEDLEKQRALIKAELDNELMEGKVQSGMGLIL 137
E+ DK +P ++ D + +A L G G G
Sbjct: 1599 GSSPEV---KDKPRAAPRAQSGSDSSP------EPKAPAPRALPRRSRSGSSSKGRGPSP 1649
Query: 138 QGYES--GSEEEGEIHEKARNGNRSST----------RSSSTKGKLELVDNKITTKKRSK 185
+G S S E AR G+RSS R S++ EL +++
Sbjct: 1650 EGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRS 1709
Query: 186 SRSKERTRHRSDKKKSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLR 245
+ S TR R+ + + E +S+S R++S S S R+K+ + +S SP R
Sbjct: 1710 ASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSAS-SPRTKTTSRRGRSPSPKPR 1768
Query: 246 --RRSQEKIGKARSPTDDKVKIEDKSKSKDRKKSPIINESRSRDR---------GKKSRS 294
+RS+ + + ++ T + S+S R++ SRSR R G SRS
Sbjct: 1769 GLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQ----RSRSRSRVTRRRRGGSGYHSRS 1824
Query: 295 PV---DLRGKSKDRRSRSKERKS--KRSETDKEKKPIKSPSKDASSGKENRSPSRRPGRS 349
P R S+ RR RS+ + KRS + P K AS RS SR P S
Sbjct: 1825 PARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLIS 1884
Query: 350 PKRRSLSPKPRDKSRRSRSPL-LNDRRSKQSKSP-----SRTLSP---GRRAKSRSLERK 400
+RRS S RRSRS + RRS+ SP SR+ +P RR++SR+ +
Sbjct: 1885 -RRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTR 1943
Query: 401 RRE-----PERRRLSSPRTRPRDDILSRRERSKDASPINRWSPTRRRSR---SPI-RRRS 451
RR P RR S RT P + RR RS+ SPI TRRRSR SP+ RRRS
Sbjct: 1944 RRSRSRTPPVTRRRSRSRTPP---VTRRRSRSR-TSPI-----TRRRSRSRTSPVTRRRS 1994
Query: 452 R---SPLRRSRSPRRRSRSPRRRDRG-------RRSRSRL----RRRSRSRG--GRRRRS 495
R SP+ R RS R S RRR R RRSRSR R+RSRSR RRRS
Sbjct: 1995 RSRTSPVTRRRSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRS 2054
Query: 496 RSKV-KEDKFKGSLSEGMKVEQESSSDDNLED 526
RS+ + + K SL+ + S+ + D
Sbjct: 2055 RSRTPRTARGKRSLTRSPPAIRRRSASGSSSD 2086
Score = 120 bits (300), Expect = 8e-27
Identities = 125/391 (31%), Positives = 184/391 (47%), Gaps = 62/391 (15%)
Query: 142 SGSEEEGEIHEKARNGNR----SSTRSSSTKGKLELVDNKITTKKRSKSRSKERTRHRSD 197
S S E EK+R+ R SS R+ +T + K +RS+SRS+ +
Sbjct: 1727 SPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTR 1786
Query: 198 KKKSKGGIEIVKEKTTRSKSKERKK----------SKSPSKRSKSQDQARKSKS-----P 242
++ G + + RS+S+ R S+SP+++ S+ +R+ + P
Sbjct: 1787 RRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSRRRRGRSRTPP 1846
Query: 243 TLRRRSQEKIGKARSPTDDKVKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKS 302
T R+RS+ + A + + + + R ++P+I+ RSR R SPV R +S
Sbjct: 1847 TSRKRSRSRTSPAPWKRS-RSRASPATHRRSRSRTPLISRRRSRSR----TSPVSRR-RS 1900
Query: 303 KDRRSRSKER-KSKRSETDKEKKPIKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKPRD 361
+ R S ++ R +S+ S + + ++P RS SR P + RS +P
Sbjct: 1901 RSRTSVTRRRSRSRASPVSRRRSRSRTPPVT-----RRRSRSRTPTTRRRSRSRTPPVTR 1955
Query: 362 KSRRSRSPLLNDRRSKQSKSP-------SRTLSPGRRAKSRSLERKRREPERRRLSSPRT 414
+ RSR+P + RRS+ SP SRT SP R +SRS R P RR S RT
Sbjct: 1956 RRSRSRTPPVTRRRSRSRTSPITRRRSRSRT-SPVTRRRSRS----RTSPVTRRRSRSRT 2010
Query: 415 RPRDDILSRRERSKDASPINRWSPTRRRSRSPI----RRRSRSPLRRSRSPRRRSRSPRR 470
P + RR RS+ I R R RSR+P+ R RSRSPL R R RSR+PR
Sbjct: 2011 SP---VTRRRSRSRTPPAIRR----RSRSRTPLLPRKRSRSRSPLAIRR--RSRSRTPRT 2061
Query: 471 RDRGRRSRSR----LRRRSRSRGGRRRRSRS 497
RG+RS +R +RRRS S G RSRS
Sbjct: 2062 A-RGKRSLTRSPPAIRRRSAS-GSSSDRSRS 2090
Score = 108 bits (271), Expect = 2e-23
Identities = 126/403 (31%), Positives = 181/403 (44%), Gaps = 75/403 (18%)
Query: 159 RSSTRSSSTKGKLELVDNKITTKKRSKSRSKERTRHRSDKKKSKGGIEIVKEKTTRSKSK 218
R S+ S S K + K +RS+S S R R +S KKK K ++ K
Sbjct: 175 RESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKK--------KHRSESESKK 226
Query: 219 ERKKSKSPSKRSKSQDQARK-SKSPTLRRRSQEKIGKARSPTDDKVKIEDKSKSKDRK-- 275
+ +S +P + KS+D+ RK S+S T +S+ RS + D D S+S+ R
Sbjct: 227 RKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRR---AHRSTSADSASSSDTSRSRSRSAA 283
Query: 276 ----KSPIINESRSRDRGKKSR--SPVDLRGKSKDRRSRSKERKSKR-----SETDKEKK 324
+ + S S G++ +P G + +R S E +K+ + DK+KK
Sbjct: 284 AKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKK 343
Query: 325 ------PIKSPSKDASSGKENRSP----SRRPGRSPK--------RRSLSPKPRDKSRRS 366
P SP + +S+G E +P + R G SP+ + ++P R
Sbjct: 344 EKSATRPSPSPER-SSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRD 402
Query: 367 RSP-----LLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRREP----ERRRLSSPRTRPR 417
RSP L S +S PS + R S S E + P R SSP ++ R
Sbjct: 403 RSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNR 462
Query: 418 DDILSRRERSKDASPINRW----SPT-----RRRSRSPIRR---RSRSP-LRRSRSPRR- 463
++R++S +P R SP R RSR+P +R RSRSP RRSRS +R
Sbjct: 463 SHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRW 522
Query: 464 -RSRSPRRRDRGRR------SRSR-LRRRSRSRGGRRRRSRSK 498
RSRSP+RR R R SRSR +RR RSR RR RS S+
Sbjct: 523 GRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSR 565
Score = 108 bits (270), Expect = 3e-23
Identities = 115/377 (30%), Positives = 154/377 (40%), Gaps = 24/377 (6%)
Query: 138 QGYESGSEEEGEIHEKARNGNRSSTRSSSTKGKLELVDNKITTKKRSKSRSKERTRHRSD 197
Q SGS +E ++ A RS + SS D+K T+ + RS+ + D
Sbjct: 1535 QRSRSGSSQELDVKPSASPQERSESDSSP--------DSKAKTRTPLRQRSRSGSSPEVD 1586
Query: 198 KKKSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLRRRSQEKIGKARS 257
K + K K R ++ S S + + RR K R
Sbjct: 1587 SKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRG 1646
Query: 258 PTDDKVKIEDKSKSKDRKKSPIINESRSRDRGK-KSRSPVDLRGKSKDRRSRSKERKSKR 316
P+ + + S K SRS K KSR+P R K R S+R
Sbjct: 1647 PSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRR 1706
Query: 317 SETDKEKKPIKS---PSKDASSGKENRSPSRRPGRSPKRRSLS-PKPRDKSRRSRSPLLN 372
S + +S P S + P+ + S +RRS S P+ + SRR RSP
Sbjct: 1707 SRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPK 1766
Query: 373 DRRSKQSKSPSR---TLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDILSRRERSKD 429
R ++S+S SR T + RR +S S + R +R R S TR R RS
Sbjct: 1767 PRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPA 1826
Query: 430 ASPINRWSPTRRR--SRSPIRRRSRSPLRRSRSPRRRSRSPRRRDRGRRSRSRL----RR 483
+R S RRR SR+P R RS R S +P +RSRS RRSRSR RR
Sbjct: 1827 RQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLISRR 1886
Query: 484 RSRSRGG--RRRRSRSK 498
RSRSR RRRSRS+
Sbjct: 1887 RSRSRTSPVSRRRSRSR 1903
Score = 104 bits (260), Expect = 4e-22
Identities = 118/452 (26%), Positives = 203/452 (44%), Gaps = 60/452 (13%)
Query: 151 HEKARNGNRSSTRSSSTKGKLELVDNKITTKKRSKSRSKER--------TRHRSDKKKSK 202
H ++R+ +RS+ G+ + ++R +SRS +R T+ R + ++
Sbjct: 505 HSRSRSPQWRRSRSAQRWGRSR------SPQRRGRSRSPQRPGWSRSRNTQRRGRSRSAR 558
Query: 203 GGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQAR-KSKSPTLRR---RSQEKIGKARSP 258
G + TR +S+ R ++ RS++ + R +S++PT RR R+ + G++RS
Sbjct: 559 RGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSR 618
Query: 259 TDDKVKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSKERKSKRSE 318
T ++ + R +SP+ SRSR SP G+S+ R + R R+
Sbjct: 619 TP--------ARRRSRTRSPVRRRSRSR-------SPARRSGRSRSRTPARRGRSRSRTP 663
Query: 319 TDKEKKPIKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKPRDKSRRSRSPLLNDRRSKQ 378
+ + ++P++ + RS SR P R + RS +P + RSRS L R
Sbjct: 664 ARRGRSRSRTPAR-----RSGRSRSRTPARRGRSRSRTP----RRGRSRSRSLVRRGRSH 714
Query: 379 SKSPSRTLSPGRRAKSRSLERKRREPERR-RLSSPRTRPRDDILSRRERSKDASPINRWS 437
S++P R GR S + K R +RR R +S + I SRR RS +SP ++ +
Sbjct: 715 SRTPQRR---GRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSL-SSPRSK-A 769
Query: 438 PTRRRSRSPIRRRSRSPLRRSRSPRRRSRSPRRRDRGRRSRSRLRRRSRSRGGRRRRSRS 497
+R R + S P ++S++P RRSRS + + +SR+ RRSRS + +S
Sbjct: 770 KSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKA-KSRTP-PRRSRSSSSPPPKQKS 827
Query: 498 KVKEDKFKGSLSEGMKVEQESSSDDNLEDFDVEEEDEEALIEQRRI--------QRQAIV 549
K + S S KV +S + + +E+++ QRR + ++
Sbjct: 828 KTPSRQSHSSSSPHPKV--KSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRT 885
Query: 550 QKYKYLAEDSNMSVPSEPSSPQSSTRTRSPSP 581
+ S V S QS +R+ SP P
Sbjct: 886 PSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQP 917
Score = 104 bits (259), Expect = 5e-22
Identities = 104/349 (29%), Positives = 159/349 (45%), Gaps = 34/349 (9%)
Query: 174 VDNKITTKKRSKSRSKERTRHRSDKKKSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQ 233
++NK T +R +S S+ ++ + G + ++ S+ + K S SP +RS+S
Sbjct: 1505 LNNKCLTPQRERSGSESSVDQKTVARTPLGQ----RSRSGSSQELDVKPSASPQERSESD 1560
Query: 234 ---DQARKSKSPTLRRRSQEKIGKARSPTDDKVKIEDKSK-SKDRKKSPIINESRSRDRG 289
D K+++P LR+RS+ SP +++ KS+ S R +S E + + R
Sbjct: 1561 SSPDSKAKTRTP-LRQRSRS----GSSP-----EVDSKSRLSPRRSRSGSSPEVKDKPRA 1610
Query: 290 K-KSRSPVDLRGKSKDRRSRSKERKSKRSETDKEKKPIKSPSKDASSGKENRSPSRRPGR 348
+++S D + K R+ R+S+ + K + P S S E+ SR R
Sbjct: 1611 APRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARR 1670
Query: 349 SPKRRSLSPKPRDKSRRSRSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRR 408
+ SP+P+ KSR P RS + LS R+ S S E + R P R R
Sbjct: 1671 GSRS---SPEPKTKSRTP--PRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHR 1725
Query: 409 LSSPRTRPRDDILSRRERSKDASPINRWSPTRRRSRSPIRRRSRSPLRRSRSPRRRSRSP 468
S + P SR R + ++ R T RR RSP + RSRS R ++R+
Sbjct: 1726 RSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTT 1785
Query: 469 RRRDRG----RRSRSRLRRRSRSRGGRRRR------SRSKVKEDKFKGS 507
RRRDR SR R R RSRSR RRRR SRS +++ + S
Sbjct: 1786 RRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTS 1834
Score = 86.7 bits (213), Expect = 1e-16
Identities = 107/475 (22%), Positives = 181/475 (38%), Gaps = 67/475 (14%)
Query: 6 TQSLREQPEMEDANSEKSINEENGEVSEDQSQNKHSRHKKKKHKHRSKHKKHKHSSEEDK 65
++S PE + + E +++ SR ++ R+K + S K
Sbjct: 1707 SRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPK 1766
Query: 66 DKKHKHKHKHKKHKRKEIIDASDKEGMSPAKRTKLDDLALLEDLEKQRALIKAELDNELM 125
+ + + ++ D+ G S + + +QR+ ++ +
Sbjct: 1767 PRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRR-----------RQRSRSRSRVTRRRR 1815
Query: 126 EGKVQSGMGLILQGYESGSEEEGEIHEKARNGNRSSTRSSSTKGKLELVDNKITTKKRSK 185
G GY S S E + R +R+ T K KRS+
Sbjct: 1816 GGS----------GYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSR 1865
Query: 186 SRSKERTRHRSDKKKSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLR 245
SR+ T RS + ++ + +RS++ + +S S+ S ++ ++R SP R
Sbjct: 1866 SRASPATHRRSRSRTP-----LISRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSR 1920
Query: 246 RRSQEKI-------GKARSPTD---DKVKIEDKSKSKDRKKSPIINESRSRDRGK----- 290
RRS+ + ++R+PT + + ++ + R ++P + RSR R
Sbjct: 1921 RRSRSRTPPVTRRRSRSRTPTTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITRR 1980
Query: 291 --KSRSPVDLRGKSKDRRSRSKERKSKRSETDKEKKPIKSPSKDASSGKENRSPSRRPGR 348
+SR+ R +S+ R S R+S+ + ++ +S + A RS SR P
Sbjct: 1981 RSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPAI---RRRSRSRTP-L 2036
Query: 349 SPKRRSLSPKPRDKSRRSRSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRRE--PER 406
P++RS S P RRSRS R K+S + S R A S +R R P
Sbjct: 2037 LPRKRSRSRSPLAIRRRSRSRTPRTARGKRSLTRSPPAIRRRSASGSSSDRSRSATPPAT 2096
Query: 407 RRLSSPRTRPRDDILSRRERSKDASPINRWSPTRRRSRSPIRRRSRSPLRRSRSP 461
R S RT P A +R S R S SP +PL R RSP
Sbjct: 2097 RNHSGSRTPP------------VALNSSRMSCFSRPSMSP------TPLDRCRSP 2133
Score = 75.1 bits (183), Expect = 3e-13
Identities = 106/439 (24%), Positives = 167/439 (38%), Gaps = 65/439 (14%)
Query: 156 NGNRSSTRSSSTKGKLELVDNKITTKKRSKSRSKERTRHRSDKKKS---KGGIEIVKEKT 212
+G+ SS S K + N+ + + + +R RS S K G+ +
Sbjct: 1379 SGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRERSSSASSPEMKDGLPRTPSRR 1438
Query: 213 TRSKSKE--RKKSKSPSKRSKSQDQARKSKSPTLRRRSQEKIGKARSPTDDKVKIEDKSK 270
+RS S R S +PS+ S S P R + + + P +S+
Sbjct: 1439 SRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPRPRSR 1498
Query: 271 SKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSKERKSKRSETDKEKKPIKSPS 330
S SP +N + ++S S + K+ R + +S S+ + + KP SP
Sbjct: 1499 SPS---SPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQ-ELDVKPSASPQ 1554
Query: 331 K--DASSGKENRSPSRRPGRSPKRRSLSPKPRDKSRRSRSPLLNDRRSKQSKSPSRTLSP 388
+ ++ S ++++ +R P R R SP+ KSR L+ RRS+ SP P
Sbjct: 1555 ERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSR------LSPRRSRSGSSPEVKDKP 1608
Query: 389 GRRAKSRSLERKRREPERRRLSSPRTRPRDDILSRRERSKDASPINRWSPTRRRSRSPIR 448
+++S EP + +PR PR + + SP S P
Sbjct: 1609 RAAPRAQSGSDSSPEP---KAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKS 1665
Query: 449 RRSRSPLRRSRSPRRRSRSPRRRDRGRRS-----RSRLRRRSRSRGGR-RRRSRSKVKED 502
R +R R S P+ +SR+P RR R S ++RL RRSRS RSR+ +
Sbjct: 1666 RTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHR 1725
Query: 503 KFKGSLSEGMKVEQESSSDDNLEDFDVEEEDEEALIEQRRIQRQAIVQKYKYLAEDSNMS 562
+ S+S E+ SS R +R A
Sbjct: 1726 R-SPSVSSPEPAEKSRSS---------------------RRRRSA--------------- 1748
Query: 563 VPSEPSSPQSSTRTRSPSP 581
S P + +S R RSPSP
Sbjct: 1749 --SSPRTKTTSRRGRSPSP 1765
Score = 74.3 bits (181), Expect = 5e-13
Identities = 132/637 (20%), Positives = 240/637 (37%), Gaps = 54/637 (8%)
Query: 35 QSQNKHSRHKKKKHKHRSKHKKHKHSSEEDKDKKHKHKHKHKKHKRKEIIDASDKEGMSP 94
+S SR ++ + RS+ + S ++ + H +R +S+++ S
Sbjct: 677 RSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGR-SHSRTPQRRGRSGSSSERKNKS- 734
Query: 95 AKRTKLDDLALLEDLEKQRALIKAELDNELMEGKVQSGMGLILQGYESGS-----EEEGE 149
RT E +++ I + L + ++ L L+ SGS ++
Sbjct: 735 --RTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQT 792
Query: 150 IHEKARNGNRSSTRSSSTKGKLELVDNKITTKKRSKSRSKERTRHRSDKKKSKGGIEIVK 209
++R+G+ S T + + K++SK+ S++ S K K G +
Sbjct: 793 PPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTPPRQ 852
Query: 210 EKTTRSKSKERKKSKSPSKRS---KSQDQARKSKSPTLRRRSQEKIGKARSPTDDKVKIE 266
T ++ E+ S +P +RS S D KS++P+ S + +S T + +
Sbjct: 853 GSITSPQANEQ--SVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPPRVKSSTPPR-QSP 909
Query: 267 DKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSKERKSKRSETDKEKKPI 326
+S S K II+ + G S SP + ++ RRSRS S + E + +
Sbjct: 910 SRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCS-----NVESRLL 964
Query: 327 KSPSKDASSGKENRSPSRRPGRSPKRRSLSPKPRDKSRRSRSPLLNDRRS----KQSKSP 382
S SS + + P R S+SP P+ K++ P L+ +S ++SK
Sbjct: 965 PRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQTPPGPSLSGSKSPCPQEKSKDS 1024
Query: 383 SRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDILSRRERSKDASPINRWSPTRRR 442
PG + ++ E S S RS +SP R S +
Sbjct: 1025 LVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQTSPDHRSDTSSPEVRQSHSESP 1084
Query: 443 S-RSPIRRRSRSPLRRSRSP--RRRSRSPRRRDRGRRSRSRLRRRSRSRGGRRRRSRSKV 499
S +S + + RS SP SRSP R+DRG S S + + S R +S S
Sbjct: 1085 SLQSKSQTSPKGGRSRSSSPVTELASRSPIRQDRGEFSASPMLKSGMSPEQSRFQSDSSS 1144
Query: 500 KEDKFKGSLSEGMKVEQESSSD------------------DNLEDFDVEEEDEEALIEQR 541
SL ++E S + D F V++ E +L+ +
Sbjct: 1145 YPTVDSNSLLGQSRLETAESKEKMALPPQEDATASPPRQKDKFSPFPVQDRPESSLVFKD 1204
Query: 542 RI-----QRQAIVQKYKYLAEDSNMSVPSEPSSPQSSTRTRSPSPDDILERVAADVKEYE 596
+ +R + ++S + S+ IL +++++KE
Sbjct: 1205 TLRTPPRERSGAGSSPETKEQNSALPTSSQDEELMEVVEKSEEPAGQILSHLSSELKEMS 1264
Query: 597 RENVDTFEASVKAKHN-LMTVEQNNGSSQKKLLAPDM 632
N FE+S + + +++ + SQ L A ++
Sbjct: 1265 TSN---FESSPEVEERPAVSLTLDQSQSQASLEAVEV 1298
Score = 67.8 bits (164), Expect = 5e-11
Identities = 98/417 (23%), Positives = 156/417 (37%), Gaps = 55/417 (13%)
Query: 197 DKKKSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLRRRSQEKIGKAR 256
D+ +S+ +E V+ + S S + S S + SP R S
Sbjct: 1285 DQSQSQASLEAVEVPSMASSWGGPHFSPEHKELSNSPLRENSFGSPLEFRNS-------- 1336
Query: 257 SPTDDKVKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSKERKSKR 316
P ++ S+ K+ P +N+ + G S S K+
Sbjct: 1337 GPLGTEMNTGFSSEVKEDLNGPFLNQLETDPSLDMKEQSTRSSGHSSSELSPDAVEKAGM 1396
Query: 317 SETDKEKKPI-----KSPSKDASSGKENRSPSRRPG--RSPKRRSLSPKPRDKSRRSRSP 369
S P+ ++PS++ SS SP + G R+P RRS R SP
Sbjct: 1397 SSNQSISSPVLDAVPRTPSRERSSSAS--SPEMKDGLPRTPSRRS---------RSGSSP 1445
Query: 370 LLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRRE----PERRRL-SSPRTRPRDD----- 419
L D S+ SPG + R+ R R E PE + L +PR R R
Sbjct: 1446 GLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPRPRSRSPSSPEL 1505
Query: 420 ----ILSRRERSKDASPINRWSPTRRRSRSPIRRRSRS------PLRRSRSPRRRSRSPR 469
+ +RERS S +++ + +R+P+ +RSRS ++ S SP+ RS S
Sbjct: 1506 NNKCLTPQRERSGSESSVDQ----KTVARTPLGQRSRSGSSQELDVKPSASPQERSESDS 1561
Query: 470 RRDRGRRSRSRLRRRSRSRGGRRRRSRSKVKEDKFKGSLSEGMKVEQESSSDDNLEDFDV 529
D ++R+ LR+RSRS S+S++ + + S +K + ++
Sbjct: 1562 SPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSS 1621
Query: 530 EEEDEEALIEQRRIQRQAIVQKYKYLAEDSNMSVPSEPSSPQSSTRTR-----SPSP 581
E A R R K + + + + S S P P S R SP P
Sbjct: 1622 PEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEP 1678
Score = 61.6 bits (148), Expect = 4e-09
Identities = 74/259 (28%), Positives = 95/259 (36%), Gaps = 40/259 (15%)
Query: 217 SKERKKSKSPSKRSKSQDQARKSKSPTLRRRSQEKIGKARS-PTDDKVKIEDKSKSKDRK 275
+KER+ S S S S S + S S + S + S P +V ++ + S
Sbjct: 2527 AKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALK-RVPSPTPA 2585
Query: 276 KSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSKERKSKRSETDKEKKPIKSPSKDASS 335
+ E R + R R S S S S S + S S +SS
Sbjct: 2586 PKEAVREGRPPEPTPAKRKR---RSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2642
Query: 336 GKENRSPS-RRPGRSPKRRSLSPK-PRDKSRRSRSPLLNDRRSKQSKSPSRTLSPGRRAK 393
+ SPS +PG + SPK P RRSRSP R+ S SR+LS
Sbjct: 2643 SSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSP----RKPIDSLRDSRSLS------ 2692
Query: 394 SRSLERKRREPERRRLSSPRTRPRDDILSRRERSKDASPINRWSPTRRRSRSPIRRRSRS 453
P RR SP+ PRD S ER +RR R R S
Sbjct: 2693 --------YSPVERRRPSPQPSPRDQQSSSSERG-----------SRRGQRGDSRSPSHK 2733
Query: 454 PLRRSRSPR----RRSRSP 468
R + SPR R SRSP
Sbjct: 2734 RRRETPSPRPMRHRSSRSP 2752
Score = 57.4 bits (137), Expect = 7e-08
Identities = 68/325 (20%), Positives = 118/325 (36%), Gaps = 29/325 (8%)
Query: 185 KSRSKERTRHRSDKKKSKGGIEIVKEKTTRSKSKERKKS--------KSPSKRSKSQDQA 236
+ R ER ++ +++ + +VK ERK+ + + ++Q
Sbjct: 27 RGRRGERPDYKGEEELRRLEAALVKRPNPDILDHERKRRVELRCLELEEMMEEQGYEEQQ 86
Query: 237 RKSKSPTLRRRSQEKI----GKARSP--------TDDKVKIEDKSKSKDRKKSPIIN--- 281
+ K T R EK GK +P T ++ +K + R I +
Sbjct: 87 IQEKVATFRLMLLEKDVNPGGKEETPGQRPAVTETHQLAELNEKKNERLRAAFGISDSYV 146
Query: 282 ESRSRDRGKKSRSPVDLRGKSKDRRSRSKERKSKRSETDKEKKPIKSPSKDASSGKENRS 341
+ S D +++R + S +E S RS T K+KK K KD E+ S
Sbjct: 147 DGSSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKK--KKKKKDRGRRSESSS 204
Query: 342 PSRRPGRSPKRRSLSPKPRDKSRRSRSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKR 401
P R +S K++ + K R+ RSP +R + K R+ S KSR R
Sbjct: 205 PRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRST 264
Query: 402 REPERRRLSSPRTRPRDDILSRRERSKDASPINRWSPTRRRSRSPIRRRSRSPLRRSRSP 461
+ R+R R + + S R +P + +R SP
Sbjct: 265 SADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSP 324
Query: 462 RRRSRSP----RRRDRGRRSRSRLR 482
++ P +D+ ++ +S R
Sbjct: 325 ETATKQPSSPYEDKDKDKKEKSATR 349
Score = 57.0 bits (136), Expect = 9e-08
Identities = 63/230 (27%), Positives = 83/230 (36%), Gaps = 18/230 (7%)
Query: 188 SKERTRHRSDKKKSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQA----RKSKSPT 243
+KER RS S ++ S S S S S+ S Q ++ SPT
Sbjct: 2527 AKER---RSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPT 2583
Query: 244 LRRRSQEKIGKARSPTDDKVKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSK 303
+ + G+ PT K K S S S + S S S S S
Sbjct: 2584 PAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2643
Query: 304 DRRSRSKERKSKRSETDKEKKPIKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKPRDKS 363
S K K P K P + + +RSP + RSLS P ++
Sbjct: 2644 SSSSSPSPAKPGPQALPKPASPKKPPPGE----RRSRSPRKPIDSLRDSRSLSYSPVERR 2699
Query: 364 RRSRSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSPR 413
R S P D++S S+ SR G+R SRS KR RR SPR
Sbjct: 2700 RPSPQPSPRDQQSSSSERGSRR---GQRGDSRSPSHKR----RRETPSPR 2742
Score = 55.1 bits (131), Expect = 3e-07
Identities = 63/240 (26%), Positives = 89/240 (37%), Gaps = 16/240 (6%)
Query: 271 SKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSKERKSKRSETDKEKKPIKSPS 330
+K+R+ S + S S S S S S E S + + K + SP+
Sbjct: 2527 AKERRSS---SSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPT 2583
Query: 331 KDASSG-KENRSPSRRPGRSPKRRSLSPKPRDKSRRSRSPLLNDRRSKQSKSPSRTLSPG 389
+E R P P + +R S S S S S S S S S + S
Sbjct: 2584 PAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSS----SSSSSSSSSSSSSSSSS 2639
Query: 390 RRAKSRSLERKRREPERRRLSSPRTRPRDDILSRRERSKDASPINRWSPTRRRSRSPIRR 449
+ S S +P + L P + + RR RS PI+ +R S SP+ R
Sbjct: 2640 SSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSP-RKPIDSLRDSRSLSYSPVER 2698
Query: 450 RSRSPLRRSRSPRRRSRSPRRRDRGRRSRSRLRRRSRSRGGRRRRSRSKVKEDKFKGSLS 509
R SP P R + +RG SR R SRS +RRR + + + S S
Sbjct: 2699 RRPSP-----QPSPRDQQSSSSERG--SRRGQRGDSRSPSHKRRRETPSPRPMRHRSSRS 2751
Score = 45.4 bits (106), Expect = 3e-04
Identities = 40/162 (24%), Positives = 59/162 (36%), Gaps = 13/162 (8%)
Query: 181 KKRSKSRSKERTRHRSDKKKSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSK 240
K+RS S S + S S ++ S S S SPS K
Sbjct: 2604 KRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPA 2663
Query: 241 SPTLRRRSQEKIGKARSPTDDKVKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRG 300
SP + + R P I+ S+ SP+ R R SP D +
Sbjct: 2664 SPKKPPPGERRSRSPRKP------IDSLRDSRSLSYSPV-----ERRRPSPQPSPRDQQS 2712
Query: 301 KSKDRRSRSKERKSKRSETDKEKKPIKSPSKDASSGKENRSP 342
S +R SR +R RS + K ++ ++PS + +RSP
Sbjct: 2713 SSSERGSRRGQRGDSRSPSHKRRR--ETPSPRPMRHRSSRSP 2752
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.128 0.350
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,008,064
Number of Sequences: 37866
Number of extensions: 1952088
Number of successful extensions: 43203
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 876
Number of HSP's successfully gapped in prelim test: 1643
Number of HSP's that attempted gapping in prelim test: 13194
Number of HSP's gapped (non-prelim): 11947
length of query: 1007
length of database: 18,247,518
effective HSP length: 112
effective length of query: 895
effective length of database: 14,006,526
effective search space: 12535840770
effective search space used: 12535840770
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.