Search of human proteins with 14150015

Search of human proteins with 14150015

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|14150015 DCN1, defective in cullin neddylation 1, domain
containing 5 [Homo sapiens]
         (237 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|14150015 DCN1, defective in cullin neddylation 1, domain cont...   492   e-139
gi|94536778 DCN1, defective in cullin neddylation 1, domain cont...   342   1e-94
gi|94536780 DCN1, defective in cullin neddylation 1, domain cont...   271   4e-73
gi|36030883 RP42 homolog [Homo sapiens]                               140   7e-34
gi|62122952 DCN1, defective in cullin neddylation 1, domain cont...   140   7e-34
gi|27735047 DCN1, defective in cullin neddylation 1, domain cont...   114   1e-25
gi|9966881 nucleoporin 107kDa [Homo sapiens]                           28   5.3  
gi|42794779 myosin 18A isoform b [Homo sapiens]                        28   6.9  
gi|28416946 myosin 18A isoform a [Homo sapiens]                        28   6.9  
gi|229892328 IQ motif containing C isoform 1 [Homo sapiens]            28   9.0  
gi|229892326 IQ motif containing C isoform 2 [Homo sapiens]            28   9.0  

>gi|14150015 DCN1, defective in cullin neddylation 1, domain
           containing 5 [Homo sapiens]
          Length = 237

 Score =  492 bits (1266), Expect = e-139
 Identities = 237/237 (100%), Positives = 237/237 (100%)

Query: 1   MPVKKKRKSPGVAAAVAEDGGLKKCKISSYCRSQPPARLISGEEHFSSKKCLAWFYEYAG 60
           MPVKKKRKSPGVAAAVAEDGGLKKCKISSYCRSQPPARLISGEEHFSSKKCLAWFYEYAG
Sbjct: 1   MPVKKKRKSPGVAAAVAEDGGLKKCKISSYCRSQPPARLISGEEHFSSKKCLAWFYEYAG 60

Query: 61  PDEVVGPEGMEKFCEDIGVEPENIIMLVLAWKLEAESMGFFTKEEWLKGMTSLQCDCTEK 120
           PDEVVGPEGMEKFCEDIGVEPENIIMLVLAWKLEAESMGFFTKEEWLKGMTSLQCDCTEK
Sbjct: 61  PDEVVGPEGMEKFCEDIGVEPENIIMLVLAWKLEAESMGFFTKEEWLKGMTSLQCDCTEK 120

Query: 121 LQNKFDFLRSQLNDISSFKNIYRYAFDFARDKDQRSLDIDTAKSMLALLLGRTWPLFSVF 180
           LQNKFDFLRSQLNDISSFKNIYRYAFDFARDKDQRSLDIDTAKSMLALLLGRTWPLFSVF
Sbjct: 121 LQNKFDFLRSQLNDISSFKNIYRYAFDFARDKDQRSLDIDTAKSMLALLLGRTWPLFSVF 180

Query: 181 YQYLEQSKYRVMNKDQWYNVLEFSRTVHADLSNYDEDGAWPVLLDEFVEWQKVRQTS 237
           YQYLEQSKYRVMNKDQWYNVLEFSRTVHADLSNYDEDGAWPVLLDEFVEWQKVRQTS
Sbjct: 181 YQYLEQSKYRVMNKDQWYNVLEFSRTVHADLSNYDEDGAWPVLLDEFVEWQKVRQTS 237


>gi|94536778 DCN1, defective in cullin neddylation 1, domain
           containing 4 isoform 1 [Homo sapiens]
          Length = 292

 Score =  342 bits (878), Expect = 1e-94
 Identities = 165/237 (69%), Positives = 194/237 (81%), Gaps = 5/237 (2%)

Query: 1   MPVKKKRKSPGVAAAVAEDGGLKKCKISSYCRSQPPARLISGEEHFSSKKCLAWFYEYAG 60
           MP +KKR+      A  +D   KK +  S  R     R+ + EE FSSK+CL WFYEYAG
Sbjct: 61  MPPRKKRRP-----ASGDDLSAKKSRHDSMYRKYDSTRIKTEEEAFSSKRCLEWFYEYAG 115

Query: 61  PDEVVGPEGMEKFCEDIGVEPENIIMLVLAWKLEAESMGFFTKEEWLKGMTSLQCDCTEK 120
            D+VVGPEGMEKFCEDIGVEPEN++MLVLAWKL+A++MG+FT +EWLKGMTSLQCD TEK
Sbjct: 116 TDDVVGPEGMEKFCEDIGVEPENVVMLVLAWKLDAQNMGYFTLQEWLKGMTSLQCDTTEK 175

Query: 121 LQNKFDFLRSQLNDISSFKNIYRYAFDFARDKDQRSLDIDTAKSMLALLLGRTWPLFSVF 180
           L+N  D+LRS LND ++FK IYRYAFDFAR+KDQRSLDI+TAK ML LLLG+ WPLF VF
Sbjct: 176 LRNTLDYLRSFLNDSTNFKLIYRYAFDFAREKDQRSLDINTAKCMLGLLLGKIWPLFPVF 235

Query: 181 YQYLEQSKYRVMNKDQWYNVLEFSRTVHADLSNYDEDGAWPVLLDEFVEWQKVRQTS 237
           +Q+LEQSKY+V+NKDQW NVLEFSRT++ DLSNYDEDGAWPVLLDEFVEW K +Q S
Sbjct: 236 HQFLEQSKYKVINKDQWCNVLEFSRTINLDLSNYDEDGAWPVLLDEFVEWYKDKQMS 292


>gi|94536780 DCN1, defective in cullin neddylation 1, domain
           containing 4 isoform 2 [Homo sapiens]
          Length = 257

 Score =  271 bits (693), Expect = 4e-73
 Identities = 139/237 (58%), Positives = 163/237 (68%), Gaps = 40/237 (16%)

Query: 1   MPVKKKRKSPGVAAAVAEDGGLKKCKISSYCRSQPPARLISGEEHFSSKKCLAWFYEYAG 60
           MP +KKR+      A  +D   KK +  S  R     R+ + EE FSSK+CL WFYEYAG
Sbjct: 61  MPPRKKRRP-----ASGDDLSAKKSRHDSMYRKYDSTRIKTEEEAFSSKRCLEWFYEYAG 115

Query: 61  PDEVVGPEGMEKFCEDIGVEPENIIMLVLAWKLEAESMGFFTKEEWLKGMTSLQCDCTEK 120
            D+VVGPEGMEKFCEDIGVEPEN++MLVLAWKL+A++MG+FT +EWLKGMTSLQCD TEK
Sbjct: 116 TDDVVGPEGMEKFCEDIGVEPENVVMLVLAWKLDAQNMGYFTLQEWLKGMTSLQCDTTEK 175

Query: 121 LQNKFDFLRSQLNDISSFKNIYRYAFDFARDKDQRSLDIDTAKSMLALLLGRTWPLFSVF 180
           L+N  D+LRS LND ++FK IYRYAFDFAR                              
Sbjct: 176 LRNTLDYLRSFLNDSTNFKLIYRYAFDFAR------------------------------ 205

Query: 181 YQYLEQSKYRVMNKDQWYNVLEFSRTVHADLSNYDEDGAWPVLLDEFVEWQKVRQTS 237
                QSKY+V+NKDQW NVLEFSRT++ DLSNYDEDGAWPVLLDEFVEW K +Q S
Sbjct: 206 -----QSKYKVINKDQWCNVLEFSRTINLDLSNYDEDGAWPVLLDEFVEWYKDKQMS 257


>gi|36030883 RP42 homolog [Homo sapiens]
          Length = 259

 Score =  140 bits (354), Expect = 7e-34
 Identities = 65/186 (34%), Positives = 117/186 (62%), Gaps = 2/186 (1%)

Query: 49  KKCLAWFYEYAGPDEV--VGPEGMEKFCEDIGVEPENIIMLVLAWKLEAESMGFFTKEEW 106
           KK    +  Y  P +   +G +G+++FC+D+ ++P +I +L++AWK  A +   F+K+E+
Sbjct: 63  KKLEQLYNRYKDPQDENKIGIDGIQQFCDDLALDPASISVLIIAWKFRAATQCEFSKQEF 122

Query: 107 LKGMTSLQCDCTEKLQNKFDFLRSQLNDISSFKNIYRYAFDFARDKDQRSLDIDTAKSML 166
           + GMT L CD  EKL+ +   +  +L +   FK+ Y++ F+FA++  Q+ LD++ A +  
Sbjct: 123 MDGMTELGCDSIEKLKAQIPKMEQELKEPGRFKDFYQFTFNFAKNPGQKGLDLEMAIAYW 182

Query: 167 ALLLGRTWPLFSVFYQYLEQSKYRVMNKDQWYNVLEFSRTVHADLSNYDEDGAWPVLLDE 226
            L+L   +    ++ ++L +   R + KD W  +L+FS  +  D+SNYDE+GAWPVL+D+
Sbjct: 183 NLVLNGRFKFLDLWNKFLLEHHKRSIPKDTWNLLLDFSTMIADDMSNYDEEGAWPVLIDD 242

Query: 227 FVEWQK 232
           FVE+ +
Sbjct: 243 FVEFAR 248


>gi|62122952 DCN1, defective in cullin neddylation 1, domain
           containing 2 [Homo sapiens]
          Length = 259

 Score =  140 bits (354), Expect = 7e-34
 Identities = 66/186 (35%), Positives = 114/186 (61%), Gaps = 2/186 (1%)

Query: 49  KKCLAWFYEYAGPDEV--VGPEGMEKFCEDIGVEPENIIMLVLAWKLEAESMGFFTKEEW 106
           KK    +  Y  P +   +G +G+++FC+D+ ++P +I +LV+AWK  A +   F+++E+
Sbjct: 63  KKLERLYGRYKDPQDENKIGVDGIQQFCDDLSLDPASISVLVIAWKFRAATQCEFSRKEF 122

Query: 107 LKGMTSLQCDCTEKLQNKFDFLRSQLNDISSFKNIYRYAFDFARDKDQRSLDIDTAKSML 166
           L GMT L CD  EKL+     L  +L D + FK+ Y++ F FA++  Q+ LD++ A +  
Sbjct: 123 LDGMTELGCDSMEKLKALLPRLEQELKDTAKFKDFYQFTFTFAKNPGQKGLDLEMAVAYW 182

Query: 167 ALLLGRTWPLFSVFYQYLEQSKYRVMNKDQWYNVLEFSRTVHADLSNYDEDGAWPVLLDE 226
            L+L   +    ++  +L +   R + +D W  +L+F   +  D+SNYDE+GAWPVL+D+
Sbjct: 183 KLVLSGRFKFLDLWNTFLMEHHKRSIPRDTWNLLLDFGNMIADDMSNYDEEGAWPVLIDD 242

Query: 227 FVEWQK 232
           FVE+ +
Sbjct: 243 FVEYAR 248


>gi|27735047 DCN1, defective in cullin neddylation 1, domain
           containing 3 [Homo sapiens]
          Length = 304

 Score =  114 bits (284), Expect = 1e-25
 Identities = 60/179 (33%), Positives = 102/179 (56%), Gaps = 5/179 (2%)

Query: 62  DEVVGPEGMEKFCEDIGVEPENIIMLVLAWKLEAESMGFFTKEEWLKGMTSLQCDCTEKL 121
           ++ +  EGME+FC D+ V+P    +L+LAWK +A +M  FT++E+  G  ++  D  + +
Sbjct: 103 EDAILEEGMERFCNDLCVDPTEFRVLLLAWKFQAATMCKFTRKEFFDGCKAISADSIDGI 162

Query: 122 QNKFDFLRSQLNDISSFKNIYRYAFDFARDKD--QRSLDIDTAKSMLALLLGR-TWPLFS 178
             +F  L ++      FK++YR+ F F  D +  QRSL  + A ++  L+  +   P+  
Sbjct: 163 CARFPSLLTEAKQEDKFKDLYRFTFQFGLDSEEGQRSLHREIAIALWKLVFTQNNPPVLD 222

Query: 179 VFYQYLEQ--SKYRVMNKDQWYNVLEFSRTVHADLSNYDEDGAWPVLLDEFVEWQKVRQ 235
            +  +L +  S  + +++D W   L F++ +  DLSNY ED AWP L D FVEW+  R+
Sbjct: 223 QWLNFLTENPSGIKGISRDTWNMFLNFTQVIGPDLSNYSEDEAWPSLFDTFVEWEMERR 281


>gi|9966881 nucleoporin 107kDa [Homo sapiens]
          Length = 925

 Score = 28.5 bits (62), Expect = 5.3
 Identities = 22/72 (30%), Positives = 31/72 (43%), Gaps = 9/72 (12%)

Query: 159 IDTAKSMLALLLGRTWPLFSVFYQYLEQSKYRVMNKDQWYNVLEFSRTVHADLSNYDEDG 218
           +D  + +    LG  W L  VF +     K RV+ ++Q     E    V   L   D DG
Sbjct: 472 LDETEELPREYLGANWTLEKVFEELQATDKKRVLEENQ-----EHYHIVQKFLILGDIDG 526

Query: 219 AWPVLLDEFVEW 230
               L+DEF +W
Sbjct: 527 ----LMDEFSKW 534


>gi|42794779 myosin 18A isoform b [Homo sapiens]
          Length = 2039

 Score = 28.1 bits (61), Expect = 6.9
 Identities = 15/38 (39%), Positives = 22/38 (57%), Gaps = 2/38 (5%)

Query: 8    KSPGVAAAVAEDGGLKKCKISSYCRSQPPARLISGEEH 45
            K+ G + A ++DG LK    +SY +S  P R  S +EH
Sbjct: 1974 KNKGPSKAASDDGSLKSSSPTSYWKSLAPDR--SDDEH 2009


>gi|28416946 myosin 18A isoform a [Homo sapiens]
          Length = 2054

 Score = 28.1 bits (61), Expect = 6.9
 Identities = 15/38 (39%), Positives = 22/38 (57%), Gaps = 2/38 (5%)

Query: 8    KSPGVAAAVAEDGGLKKCKISSYCRSQPPARLISGEEH 45
            K+ G + A ++DG LK    +SY +S  P R  S +EH
Sbjct: 1989 KNKGPSKAASDDGSLKSSSPTSYWKSLAPDR--SDDEH 2024


>gi|229892328 IQ motif containing C isoform 1 [Homo sapiens]
          Length = 546

 Score = 27.7 bits (60), Expect = 9.0
 Identities = 13/42 (30%), Positives = 21/42 (50%)

Query: 3   VKKKRKSPGVAAAVAEDGGLKKCKISSYCRSQPPARLISGEE 44
           VK   +SPG  A   ++    KC+   Y +S PP+ + S  +
Sbjct: 331 VKSPHRSPGSLATTQKNIAGAKCREPCYSKSGPPSSIPSNSQ 372


>gi|229892326 IQ motif containing C isoform 2 [Homo sapiens]
          Length = 466

 Score = 27.7 bits (60), Expect = 9.0
 Identities = 13/42 (30%), Positives = 21/42 (50%)

Query: 3   VKKKRKSPGVAAAVAEDGGLKKCKISSYCRSQPPARLISGEE 44
           VK   +SPG  A   ++    KC+   Y +S PP+ + S  +
Sbjct: 251 VKSPHRSPGSLATTQKNIAGAKCREPCYSKSGPPSSIPSNSQ 292


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.418 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,160,142
Number of Sequences: 37866
Number of extensions: 385747
Number of successful extensions: 851
Number of sequences better than 10.0: 11
Number of HSP's better than 10.0 without gapping: 8
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 839
Number of HSP's gapped (non-prelim): 14
length of query: 237
length of database: 18,247,518
effective HSP length: 99
effective length of query: 138
effective length of database: 14,498,784
effective search space: 2000832192
effective search space used: 2000832192
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.