Search of human proteins with 8922854

Search of human proteins with 8922854

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|8922854 kelch-like 26 [Homo sapiens]
         (615 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|8922854 kelch-like 26 [Homo sapiens]                              1253   0.0  
gi|45643138 kelch-like 13 [Homo sapiens]                              471   e-132
gi|24308181 kelch-like 9 [Homo sapiens]                               465   e-131
gi|31542246 kelch-like 36 [Homo sapiens]                              376   e-104
gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo...   369   e-102
gi|24432026 kelch-like [Homo sapiens]                                 325   6e-89
gi|55741643 kelch-like 14 [Homo sapiens]                              318   7e-87
gi|156616301 kelch-like 32 [Homo sapiens]                             291   2e-78
gi|226442729 kelch-like 15 [Homo sapiens]                             288   8e-78
gi|40807500 kelch-like 20 [Homo sapiens]                              273   4e-73
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]                     260   3e-69
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]                     260   3e-69
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]            255   1e-67
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]            255   1e-67
gi|14780904 kelch-like 1 protein [Homo sapiens]                       253   3e-67
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]                     249   4e-66
gi|55925604 kelch-like 18 [Homo sapiens]                              249   5e-66
gi|166235129 kelch-like 3 [Homo sapiens]                              248   9e-66
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]                     246   4e-65
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]                     241   1e-63
gi|23397572 kelch-like 34 [Homo sapiens]                              228   1e-59
gi|38194229 kelch-like 17 [Homo sapiens]                              228   1e-59
gi|11056006 kelch-like 12 [Homo sapiens]                              224   1e-58
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]              223   4e-58
gi|109150407 kelch-like 6 [Homo sapiens]                              221   1e-57
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]        217   2e-56
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]        217   2e-56
gi|5174473 intracisternal A particle-promoted polypeptide isofor...   209   8e-54
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]                    208   1e-53
gi|55925608 kelch-like 21 [Homo sapiens]                              208   1e-53

>gi|8922854 kelch-like 26 [Homo sapiens]
          Length = 615

 Score = 1253 bits (3241), Expect = 0.0
 Identities = 615/615 (100%), Positives = 615/615 (100%)

Query: 1   MAESGGSSGGAGGGGAFGAGPGPERPNSTADKNGALKCTFSAPSHSTSLLQGLATLRAQG 60
           MAESGGSSGGAGGGGAFGAGPGPERPNSTADKNGALKCTFSAPSHSTSLLQGLATLRAQG
Sbjct: 1   MAESGGSSGGAGGGGAFGAGPGPERPNSTADKNGALKCTFSAPSHSTSLLQGLATLRAQG 60

Query: 61  QLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREASQDVIELKGVSARGLRHIIDF 120
           QLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREASQDVIELKGVSARGLRHIIDF
Sbjct: 61  QLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREASQDVIELKGVSARGLRHIIDF 120

Query: 121 AYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMSVETCLNIGQMATTFSLASL 180
           AYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMSVETCLNIGQMATTFSLASL
Sbjct: 121 AYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMSVETCLNIGQMATTFSLASL 180

Query: 181 RESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQSCAEIDLFRAAVRWLQHDPAR 240
           RESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQSCAEIDLFRAAVRWLQHDPAR
Sbjct: 181 RESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQSCAEIDLFRAAVRWLQHDPAR 240

Query: 241 RPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLCRQYLLEAFNYQVLPFRQHEMQSP 300
           RPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLCRQYLLEAFNYQVLPFRQHEMQSP
Sbjct: 241 RPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLCRQYLLEAFNYQVLPFRQHEMQSP 300

Query: 301 RTAVRSDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPGARHFRELTEMEVGCSHTCVAVLD 360
           RTAVRSDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPGARHFRELTEMEVGCSHTCVAVLD
Sbjct: 301 RTAVRSDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPGARHFRELTEMEVGCSHTCVAVLD 360

Query: 361 NFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQAMQESRIQFQLNVLCGMVYATGG 420
           NFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQAMQESRIQFQLNVLCGMVYATGG
Sbjct: 361 NFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQAMQESRIQFQLNVLCGMVYATGG 420

Query: 421 RNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAGAASGGRLYISGGYGISVEDKKALHC 480
           RNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAGAASGGRLYISGGYGISVEDKKALHC
Sbjct: 421 RNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAGAASGGRLYISGGYGISVEDKKALHC 480

Query: 481 YDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGRMDHVDRCFDVLAVEYYVPETDQWT 540
           YDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGRMDHVDRCFDVLAVEYYVPETDQWT
Sbjct: 481 YDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGRMDHVDRCFDVLAVEYYVPETDQWT 540

Query: 541 SVSPMRAGQSEAGCCLLERKIYIVGGYNWRLNNVTGIVQVYNTDTDEWERDLHFPESFAG 600
           SVSPMRAGQSEAGCCLLERKIYIVGGYNWRLNNVTGIVQVYNTDTDEWERDLHFPESFAG
Sbjct: 541 SVSPMRAGQSEAGCCLLERKIYIVGGYNWRLNNVTGIVQVYNTDTDEWERDLHFPESFAG 600

Query: 601 IACAPVLLPRAGTRR 615
           IACAPVLLPRAGTRR
Sbjct: 601 IACAPVLLPRAGTRR 615


>gi|45643138 kelch-like 13 [Homo sapiens]
          Length = 655

 Score =  471 bits (1211), Expect = e-132
 Identities = 249/574 (43%), Positives = 354/574 (61%), Gaps = 8/574 (1%)

Query: 40  FSAPSHSTSLLQGLATLRAQGQLLDVVLTINR--EAFPAHKVVLAACSDYFRAMFTGGMR 97
           F++ +HS+ +LQG   LR +G L DV L      +AFP H+V++A+ SDYF+AMFTGGM+
Sbjct: 69  FTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMK 128

Query: 98  EASQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLK 157
           E     I+L GVS  GLR IIDF Y+A+++L++D +QD L AA FLQ+LPV++ C+ FL 
Sbjct: 129 EQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLI 188

Query: 158 AAMSVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNR 217
           + ++++ C+ +G++A T++L  + + V++F  ++F  +    +FL+LP ERL F L SN 
Sbjct: 189 SGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNS 248

Query: 218 LQSCAEIDLFRAAVRWLQHDPARRPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLC 277
           L+ C E++LF+A  RWL+ +  R   A+ ++ +IRFPLM   EL++ VQT+D M  D  C
Sbjct: 249 LKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTC 308

Query: 278 RQYLLEAFNYQVLPFRQHEMQSPRTAVRSDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPG 337
              LLEA NYQ++P+ Q  MQS RTA+RSD   LVT GG       + V SK  ++ +  
Sbjct: 309 VNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVL---RQQLVVSKELRMYDEK 365

Query: 338 ARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQ 397
           A  ++ L  M+       +AV+ NF+YV GGQ      G+ AVD  +R+DP  N+W+++ 
Sbjct: 366 AHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVA 425

Query: 398 AMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAGAA 457
           ++ E R  F L+ L G +YA GGRN AG L +VE Y PR NEW Y   +    +GHAG  
Sbjct: 426 SLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTV 485

Query: 458 SGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGRM 517
            GG +YISGG       K+ L C+DP  D+W  KAPM+  R LH M   G R+Y +GG  
Sbjct: 486 YGGVMYISGGITHDTFQKE-LMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNH 544

Query: 518 DHVDRCF-DVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNWRLNNVTG 576
                 + DVL+ EYY P  DQWT ++ M  GQS+ G  + E KIY+VGGY+W    +  
Sbjct: 545 FRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVE 604

Query: 577 IVQVYNTDTDEWERDLHFPESFAGI-ACAPVLLP 609
           IVQ Y+ D DEW +    PES  GI AC   + P
Sbjct: 605 IVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFP 638


>gi|24308181 kelch-like 9 [Homo sapiens]
          Length = 617

 Score =  465 bits (1196), Expect = e-131
 Identities = 245/574 (42%), Positives = 353/574 (61%), Gaps = 8/574 (1%)

Query: 40  FSAPSHSTSLLQGLATLRAQGQLLDVVLTINR--EAFPAHKVVLAACSDYFRAMFTGGMR 97
           F++ +HS+ +LQG   LR +G L DV L      E FP H+ ++A+ SDYF+AMFTGGM+
Sbjct: 27  FTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMK 86

Query: 98  EASQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLK 157
           E     I+L GV+  GL+ IIDF Y+A+++L++D +QD L AA FLQ+LPV++ C+ FL 
Sbjct: 87  EQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLI 146

Query: 158 AAMSVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNR 217
           + +S++ C+ +G++A T++L  + + V+ F  ++F  +    +FL+LP ERL F L SN 
Sbjct: 147 SGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNS 206

Query: 218 LQSCAEIDLFRAAVRWLQHDPARRPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLC 277
           L+ C E++LF+AA RWL+ +  R   A+ ++ +IRFPLM   +L++ VQT+D M  D  C
Sbjct: 207 LKHCTELELFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTC 266

Query: 278 RQYLLEAFNYQVLPFRQHEMQSPRTAVRSDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPG 337
              LLEA NYQ++P+ Q  MQS RTA+RSD   LVT GG       + V SK  ++ +  
Sbjct: 267 VNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVL---RQQLVVSKELRMYDER 323

Query: 338 ARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQ 397
           A+ +R L  M+       +AV+ NF+YV GGQ      G+ AVD  +R+DP  N+W+++ 
Sbjct: 324 AQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVA 383

Query: 398 AMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAGAA 457
           ++ E R  F L+ L G +YA GGR+ AG LA+VE Y PR NEW Y   +    +GHAG  
Sbjct: 384 SLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTV 443

Query: 458 SGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGRM 517
            GG +YISGG        + L C+DP  D+W  KAPM+  R LH M   G ++Y +GG  
Sbjct: 444 YGGLMYISGGITHDTFQNE-LMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNH 502

Query: 518 DHVDRCF-DVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNWRLNNVTG 576
                 + DVL+ EYY P  DQWT ++ M  GQS+ G  + E KIY+VGGY+W    +  
Sbjct: 503 FRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVE 562

Query: 577 IVQVYNTDTDEWERDLHFPESFAGI-ACAPVLLP 609
           IVQ Y+ + DEW +    PES  GI AC   + P
Sbjct: 563 IVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFP 596


>gi|31542246 kelch-like 36 [Homo sapiens]
          Length = 616

 Score =  376 bits (965), Expect = e-104
 Identities = 213/573 (37%), Positives = 324/573 (56%), Gaps = 9/573 (1%)

Query: 45  HSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREASQDVI 104
           HS+++LQ L   R +G   DVVL  + +  PAH+ +LA CSDYF +MFT GMREA Q  +
Sbjct: 28  HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEV 87

Query: 105 ELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMSVET 164
           EL G S  GL+ ++DF Y  E+ LD   +  VL  A  LQ+  VV+ C E+L+  +S + 
Sbjct: 88  ELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDN 147

Query: 165 CLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLR-LPLERLVFFLQSNRLQSCAE 223
            L + ++A+ +SL  L   +D F   HF  ++   DFL+ + +++L  +L S+ +Q   E
Sbjct: 148 YLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLSSSEVQRECE 207

Query: 224 IDLFRAAVRWLQHDPARRPRASHVLCHIRFPLMQSSELVDSVQ--TLDIMVEDVLCRQYL 281
            DL +AA++WL   P R   A  VL +I FPL+  ++L+  V+     ++ ++  C  ++
Sbjct: 208 HDLLQAALQWLTQQPEREAHARQVLENIHFPLIPKNDLLHRVKPAVCSLLPKEANCEGFI 267

Query: 282 LEAFNYQVLPFRQHEMQSPRTAVRSDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPGARHF 341
            EA  Y      Q  MQ+ RTA+R++   L+  GG   ++    +S     L     +  
Sbjct: 268 EEAVRYHNNLAAQPVMQTKRTALRTNQERLLFVGG-EVSERCLELSDDTCYLDAKSEQWV 326

Query: 342 RELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQAMQE 401
           +E T +    SH CVAVL  F+++AGG   +   G+ A +  YRYDP   +W+++ +M +
Sbjct: 327 KE-TPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIKVASMNQ 385

Query: 402 SRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAGAASGGR 461
            R+ F L  +  M+ A GGRN  G+L+SVE Y P+ + W Y   L R T+GHAG      
Sbjct: 386 RRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAGTIYKDF 445

Query: 462 LYISGGYGISVED-KKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGRMDHV 520
           +YISGG+   +   +K L CYD   D WE + PM+  R  H+M   G  IY++GG  D++
Sbjct: 446 VYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSDDNI 505

Query: 521 DRC--FDVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNWRLNNVTGIV 578
           +    FDVL VE Y P+ +QWT V+P+    SE+G  + E +IYI+GGY+W     +  V
Sbjct: 506 ESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWENTAFSKTV 565

Query: 579 QVYNTDTDEWERDLHFPESFA-GIACAPVLLPR 610
           QVY+ + D+W R +  P++ A G AC   L PR
Sbjct: 566 QVYDREADKWSRGVDLPKAIAGGSACVCALEPR 598


>gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo
           sapiens]
          Length = 634

 Score =  369 bits (946), Expect = e-102
 Identities = 210/595 (35%), Positives = 336/595 (56%), Gaps = 15/595 (2%)

Query: 27  NSTADKNGALKCTFSA---PSHSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVVLAA 83
           N   +    L C  S     S+  +LL+GL+ +R +  L D+V+    ++F  HK V+A+
Sbjct: 34  NGLLEGGNGLSCISSELTDASYGPNLLEGLSKMRQENFLCDLVIGTKTKSFDVHKSVMAS 93

Query: 84  CSDYFRAMFTGGMREASQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFL 143
           CS+YF  +     ++ S   ++L  +S  GL  +I +AY+ ++TL L  +  ++ AAV+L
Sbjct: 94  CSEYFYNILK---KDPSIQRVDLNDISPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYL 150

Query: 144 QMLPVVELCEEFLKAAMSVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLR 203
           Q+  +V++C +FL   MSVE C+ +  +A T+SL + + +   F   +FL+ AE + F++
Sbjct: 151 QIHTLVKMCSDFLIREMSVENCMYVVNIAETYSLKNAKAAAQKFIRDNFLEFAESDQFMK 210

Query: 204 LPLERLVFFLQSNRLQSCAEIDLFRAAVRWLQHDPARRPRASHVLCHIRFPLMQSSELVD 263
           L  E++   L  + LQ  +EI  F+ A++WL+ D  R   A+ +L +IRF  + + +LV+
Sbjct: 211 LTFEQINELLIDDDLQLPSEIVAFQIAMKWLEFDQKRVKYAADLLSNIRFGTISAQDLVN 270

Query: 264 SVQTLDIMVEDVLCRQYLLEAFNYQVLPFRQHEMQSPRTAVRSDVPSLVTFGGTPYTDSD 323
            VQ++  M++D  C + L++A NY +LP+ Q+ +QS RT +R     LVT GG P   ++
Sbjct: 271 YVQSVPRMMQDADCHRLLVDAMNYHLLPYHQNTLQSRRTRIRGGCRVLVTVGGRPGL-TE 329

Query: 324 RSVSSKV-YQLPEPGARHFRELTEMEVGCSHTCVAVLDNFVYVAGG--QHLQYRSGEGAV 380
           +S+S  + Y+ PE G   + +LTEM     + CVAV+D F+YVAGG  Q+      + AV
Sbjct: 330 KSLSRDILYRDPENG---WSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAV 386

Query: 381 DACYRYDPHLNRWLRLQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEW 440
               RYDP  N W+ L +M + R  F L+V  G+VYA GGRN  GSLAS+E Y P  N+W
Sbjct: 387 SNFCRYDPRFNTWIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQW 446

Query: 441 GYACSLKRRTWGHAGAASGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVL 500
                L+     HA A + GR+ ++GGY I+    +++  YDP +D W+    +S PR  
Sbjct: 447 QPKTPLEVARCCHASAVADGRVLVTGGY-IANAYSRSVCAYDPASDSWQELPNLSTPRGW 505

Query: 501 HAMVGAGGRIYALGG-RMDHVDRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLER 559
           H  V    R+Y +GG ++       DVL VE Y P T QW+  +P++ G S AG   L  
Sbjct: 506 HCAVTLSDRVYVMGGSQLGPRGERVDVLTVECYSPATGQWSYAAPLQVGVSTAGVSALHG 565

Query: 560 KIYIVGGYNWRLNNVTGIVQVYNTDTDEWERDLHFPESFAGIACAPVLLPRAGTR 614
           + Y+VGG+N         +Q ++ + +EW  D   PE+  G++C  + +P   TR
Sbjct: 566 RAYLVGGWNEGEKKYKKCIQCFSPELNEWTEDDELPEATVGVSCCTLSMPNNVTR 620


>gi|24432026 kelch-like [Homo sapiens]
          Length = 634

 Score =  325 bits (834), Expect = 6e-89
 Identities = 195/582 (33%), Positives = 300/582 (51%), Gaps = 20/582 (3%)

Query: 39  TFSAPSHSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMRE 98
           T+ +  HS +LL+GL  LR  G L DVVL +      AH+++LAA  DYFR MF GG++E
Sbjct: 26  TYRSAQHSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKE 85

Query: 99  ASQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKA 158
             Q+ + + GVS   +  I+ F Y++E+ L L  VQ+ L AA  LQ+  ++  C +FL +
Sbjct: 86  MEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMS 145

Query: 159 AMSVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRL 218
            +  E  L++ ++A  F L+ L E +D +  ++F+  +  + + +LPLE++   L SNRL
Sbjct: 146 WVDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRL 205

Query: 219 QSCAEIDLFRAAVRWLQHDPARRPRASHVLCH--------IRFPLMQSSELVDSVQTLDI 270
           +   E +++  A+  L H    + +A  +  H        +RFPLM++  L    Q L  
Sbjct: 206 EVSCETEVYEGAL--LYHYSLEQVQADQISLHEPPKLLETVRFPLMEAEVL----QRLHD 259

Query: 271 MVEDVLCRQYLLEAFNYQVLPFRQHEMQSPRTAVRSDVPSLVTFGGTPYTDSDRSVSSKV 330
            ++    R  +  A  Y      Q  +QSP+T +RSD   +V FGG   T S        
Sbjct: 260 KLDPSPLRDTVASALMYHRNESLQPSLQSPQTELRSDFQCVVGFGGIHSTPSTVLSDQAK 319

Query: 331 YQLPEPGA-RHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPH 389
           Y  P  G  +HF     +    S+  +AVL+NFVY+ GG +     G  A   C+RYDP 
Sbjct: 320 YLNPLLGEWKHF--TASLAPRMSNQGIAVLNNFVYLIGGDN--NVQGFRAESRCWRYDPR 375

Query: 390 LNRWLRLQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRR 449
            NRW ++Q++Q+      + V+   +YA  GR+    L +VERY P  N W Y   LKR 
Sbjct: 376 HNRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKRE 435

Query: 450 TWGHAGAASGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGR 509
            + HAGA   G++YI+ G     +  K  HCYDP ++ W   A     R  H M     +
Sbjct: 436 VYAHAGATLEGKMYITCGRR-GEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMATLLNK 494

Query: 510 IYALGGRMDHVDRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNW 569
           +Y +GG  +      DV  V  Y   + QW+SV P+ AG  E G  +L+ +IY++GG + 
Sbjct: 495 LYVIGGSNNDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSH 554

Query: 570 RLNNVTGIVQVYNTDTDEWERDLHFPESFAGIACAPVLLPRA 611
              + TG V +Y+ + D WE       S +G+A   + LPR+
Sbjct: 555 NRGSRTGYVHIYDVEKDCWEEGPQLDNSISGLAACVLTLPRS 596


>gi|55741643 kelch-like 14 [Homo sapiens]
          Length = 628

 Score =  318 bits (816), Expect = 7e-87
 Identities = 212/632 (33%), Positives = 316/632 (50%), Gaps = 67/632 (10%)

Query: 32  KNGALKCTFSAPSHSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAM 91
           ++G    TF  PSHS +LL GL  L  +    DV LT   + F  HK VLA+CS YFR++
Sbjct: 3   RSGDRTSTFD-PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSL 61

Query: 92  FT------GGM-----------------REASQDV------------------------- 103
           F+      GG+                 ++ SQ                           
Sbjct: 62  FSSHPPLGGGVGGQDGLGAPKDQQQPPQQQPSQQQQPPPQEEPGTPSSSPDDKLLTSPRA 121

Query: 104 ---IELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAM 160
              + L+G S+ GLR ++++ Y+A VTL LD V++VL  +  L +  V +LC +FL   +
Sbjct: 122 INNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQI 181

Query: 161 SVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQS 220
           SV+    + ++A    L   ++  + +           ED L L  E +   L S     
Sbjct: 182 SVQNYKQVCKIAALHGLEETKKLANKYLV---------EDVLLLNFEEMRALLDSLPPPV 232

Query: 221 CAEIDLFRAAVRWLQHDPARRPR-ASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLCRQ 279
            +E+ LF+ +V WL+HD   R + A  ++  +RF L+ + ELV+ VQ++D M  D +C++
Sbjct: 233 ESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQK 292

Query: 280 YLLEAFNYQVLPFRQHEMQSPRTAVRSDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPGAR 339
            LL+A NY ++PFRQH  QS  + +RS+   L+  GG P    DR + S + Q  +   +
Sbjct: 293 LLLDAMNYHLMPFRQHCRQSLASRIRSNKKMLLLVGGLP-PGPDR-LPSNLVQYYDDEKK 350

Query: 340 HFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQAM 399
            ++ LT M    +H CV  ++NF++V GG+     +G+ + +   RYDP  N W++L  M
Sbjct: 351 TWKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPM 410

Query: 400 QESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAGAASG 459
           QE R  F    L   +Y  GGRN  G L+SVE Y    NEW Y  SL +    HAGA   
Sbjct: 411 QERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHN 470

Query: 460 GRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGRMDH 519
           G++YISGG   + E    L+CYDPV D W  K  M+  R +H +     R+YA+GG    
Sbjct: 471 GKIYISGGVH-NGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLK 529

Query: 520 VDRCFDVLAVEYYVPETDQWTSV-SPMRAGQSEAGCCLLERKIYIVGGYNWRLNNVTGIV 578
                DV+ VE Y P+ DQW  + +P+  G+S  GC +L+  IY+VGGY+W +       
Sbjct: 530 GFSHLDVMLVECYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSST 589

Query: 579 QVYNTDTDEW-ERDLHFPESFAGIACAPVLLP 609
             Y  +   W E +    E  AG AC  V+LP
Sbjct: 590 ICYCPEKGTWTELEGDVAEPLAGPACVTVILP 621


>gi|156616301 kelch-like 32 [Homo sapiens]
          Length = 620

 Score =  291 bits (744), Expect = 2e-78
 Identities = 192/578 (33%), Positives = 298/578 (51%), Gaps = 14/578 (2%)

Query: 44  SHSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREASQDV 103
           SH+ S+L  L   R+ G L D+ L    + F AHK VLAACSDYFRAMF+  M E+  D 
Sbjct: 23  SHNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVESGADE 82

Query: 104 IELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMSVE 163
           + L GV++ GL+  ++FAY+ ++ L+   +QDVL A   LQ+L ++ LC  +L   ++  
Sbjct: 83  VNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSF 142

Query: 164 TCLNIGQMATTFSLASLRESVDAFTFRHFLQI--AEEEDFLRLPLERLVFFLQSNRLQSC 221
             L++ ++A  F+L  L ++V  F  +H  ++  +  E+ L LP   L   L+S+RL S 
Sbjct: 143 NYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKSDRLTSL 202

Query: 222 AEIDLFRAAVRWLQHDPARRPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLCRQYL 281
           +E  +++ AVRWL+H+         +L +IRF LM    L     +  ++         +
Sbjct: 203 SEEQIWQLAVRWLEHN-CHYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQASETATALV 261

Query: 282 LEAFNYQVLPFRQHEMQSPRTAVRSDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPGA--- 338
            EA  Y    + Q   Q+ RT  R    +L   GG                + +  A   
Sbjct: 262 NEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKREVCKVKELRYFNPVDQENALIA 321

Query: 339 --RHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEG-AVDACYRYDPHLNRWLR 395
              ++ EL  M VG SH CVAV+ +F++VAGG+ +++ SG   AV    RYDP  N W  
Sbjct: 322 AIANWSELAPMPVGRSHHCVAVMGDFLFVAGGE-VEHASGRTCAVRTACRYDPRSNSWAE 380

Query: 396 LQAMQESRIQFQLNVLCGMVYATGGRNRAGS-LASVERYCPRRNEWGYACSLKRRTWGHA 454
           +  M+  R  F L  +   +YA GGRN     L +VERYCP++N+W +  S  R    HA
Sbjct: 381 IAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHA 440

Query: 455 GAASGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALG 514
           G  + G L+ISGG   + + +  L  Y+P  ++W  ++PM + RV H+M     ++Y LG
Sbjct: 441 GYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLG 500

Query: 515 GR-MDHVDRCFDVLAVEYYVPETDQWTSVS-PMRAGQSEAGCCLLERKIYIVGGYNWRLN 572
           G  +D+ +    V  ++ Y  +TDQWT  +  +  GQ+E+G  +   +IY+VGGY+   N
Sbjct: 501 GNDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYLVGGYSIWTN 560

Query: 573 NVTGIVQVYNTDTDEWERDLHFPE-SFAGIACAPVLLP 609
                +QV +   +  E   + P   FA    A   LP
Sbjct: 561 EPLACIQVLDVSREGKEEVFYGPTLPFASNGIAACFLP 598


>gi|226442729 kelch-like 15 [Homo sapiens]
          Length = 604

 Score =  288 bits (738), Expect = 8e-78
 Identities = 181/575 (31%), Positives = 288/575 (50%), Gaps = 32/575 (5%)

Query: 40  FSAPSHSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREA 99
           F +  H TS+  G   L  +G LLDV L I    F AHK +LA  SDYFR MFT  MRE 
Sbjct: 8   FCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRER 67

Query: 100 SQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAA 159
            QD I LKG++A G  H++ F Y   + L ++ V ++L AA+++Q++ VV+ C  FL A 
Sbjct: 68  DQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAK 127

Query: 160 MSVETCLNIGQMATTF--SLASLRESVDAFTFRHFLQIAEEEDFLR-LPLERLVFFLQSN 216
           + +E C  I ++   F  ++  +RE +D F   +F+ +    DFL  L  E+L+ +L ++
Sbjct: 128 ICLENCAEIMRLLDDFGVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEKLMSYLDND 187

Query: 217 RLQSCAEIDLFRAAVRWLQHDPARRPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVL 276
            L    EI+L+ A   WL+HD  R      ++ +IRF LM  + + + V+T +       
Sbjct: 188 HLSRFPEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFYRYSRQ 247

Query: 277 CRQYLLEAFNYQVLPFRQHEMQSPRTAVRSDVPSLVTFGGTPYTDSDRSVSSKVYQLPEP 336
            R  + +A NY     +Q  +    + +RS  P    F G         V+SK+  L +P
Sbjct: 248 LRYEVDQALNYFQNVHQQPLLDMKSSRIRSAKPQTTVFRG---MIGHSMVNSKILLLKKP 304

Query: 337 GARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRL 396
             R + EL   +V     C+A+++NFV++ GG+ L       A    +RYDP  N WL++
Sbjct: 305 --RVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLQM 362

Query: 397 QAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAGA 456
             M   R +F + V+   +YA  GR R  +  S ERY    ++W +        +GH G 
Sbjct: 363 ADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGT 422

Query: 457 ASGGRLYISGGYGISVEDKKALHCYDP---------------VADQWEFKAPMSEPRVLH 501
               +L+I+GG   S    K +  +DP               V + WE K+ M+  R  H
Sbjct: 423 VLNNKLFITGGI-TSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFH 481

Query: 502 AMVGAGGRIYALGGRMDHVDRCFD---VLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLE 558
            M+   G++Y  GG    +   F+     + E Y PETDQWT ++ M  G+S  G  +L+
Sbjct: 482 KMISYNGKLYVFGGVCVILRASFESQGCPSTEVYNPETDQWTILASMPIGRSGHGVTVLD 541

Query: 559 RKIYIVGG--YNWRLNNVTGIVQVYNTDTDEWERD 591
           ++I ++GG  YN    + +  +  ++ D ++W+ D
Sbjct: 542 KQIMVLGGLCYN---GHYSDSILTFDPDENKWKED 573


>gi|40807500 kelch-like 20 [Homo sapiens]
          Length = 609

 Score =  273 bits (697), Expect = 4e-73
 Identities = 177/554 (31%), Positives = 274/554 (49%), Gaps = 22/554 (3%)

Query: 40  FSAPSHSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREA 99
           + +  H    L+ +  LR   +L DVVL +  +   AH+V+L+ACS YFRAMFTG + E+
Sbjct: 45  YISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAES 104

Query: 100 SQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAA 159
            Q  + ++ +  R +  +IDFAY++++T++   VQ +L AA  LQ+  + E C EFLK  
Sbjct: 105 RQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQ 164

Query: 160 MSVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQ 219
           +    CL I   A T S   L    D FT  +F ++ E E+F+ LP  +L+  + S+ L 
Sbjct: 165 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELN 224

Query: 220 SCAEIDLFRAAVRWLQHD-PARRPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLCR 278
             +E  +F A + W+++    RRP+   VL H+R PL+    LV +V +  ++  D  CR
Sbjct: 225 VRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECR 284

Query: 279 QYLLEAFNYQVLPFRQHEMQSPRTAVRSDV---PSLVTFGGTPYTDSDRSVSSKVYQLPE 335
             + EA NY +LP  +  MQ PRT  R  +     L   GG    D+  SV     +  +
Sbjct: 285 DLVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSV-----ERYD 339

Query: 336 PGARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLR 395
           P    +R +  M        V+VLD+ +Y  GG       G   +++  RYDP  N+W  
Sbjct: 340 PQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGG-----HDGSSYLNSVERYDPKTNQWSS 394

Query: 396 -LQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHA 454
            +      R    + VL G +YA GG++    L  VERY P+ N+W    S+  R  G A
Sbjct: 395 DVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVA 454

Query: 455 GAASGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALG 514
            A  GG LY  GG          +  Y+P  ++W   APM   R           IYA+G
Sbjct: 455 VAVLGGFLYAVGG-SDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVG 513

Query: 515 GRMDHVDRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNWRLNNV 574
           GR    D   ++ + E Y P T+QW+ V  M + +S  G  ++  ++  VGG++      
Sbjct: 514 GR----DDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLK 569

Query: 575 TGIVQVYNTDTDEW 588
           T  ++V++ D + W
Sbjct: 570 T--IEVFDPDANTW 581


>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
          Length = 709

 Score =  260 bits (664), Expect = 3e-69
 Identities = 178/577 (30%), Positives = 274/577 (47%), Gaps = 30/577 (5%)

Query: 40  FSAPSHSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREA 99
           F A +H+    + +       QL DV+L       PAH++VL++ SDYF AMFT  +REA
Sbjct: 151 FQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREA 210

Query: 100 SQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAA 159
            Q+ I+++GV    L  +I +AY+  + L  D ++ +L  A  LQ+  VVE C +FL   
Sbjct: 211 RQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQ 270

Query: 160 MSVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQ 219
           +    CL I   A       L +    +T  HF+++   ++F+ LP   +   L S+ + 
Sbjct: 271 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMN 330

Query: 220 SCAEIDLFRAAVRWLQHD-PARRPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLCR 278
              E  +  A + W++HD   RR   S +L +IR PL+    L D    + +  +D+ C+
Sbjct: 331 IPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADMENNV-LFRDDIECQ 389

Query: 279 QYLLEAFNYQVLPFRQHEMQSPRTAVR-SDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPG 337
           + ++EA  Y +LP R+  +QSPRT  R S V +L   GG   T    S+    Y L    
Sbjct: 390 KLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEK--YDL---R 444

Query: 338 ARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQ 397
              +  +  M        VAVLD+ +YV GG     R G   ++    Y+P    W  + 
Sbjct: 445 TNMWTPVANMNGRRLQFGVAVLDDKLYVVGG-----RDGLKTLNTVECYNPKTKTWSVMP 499

Query: 398 AMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAGAA 457
            M   R    + VL G +YA GG +    L +VER+ P+  +W +  ++         A 
Sbjct: 500 PMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAV 559

Query: 458 SGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGRM 517
             G+LY  GG   S    K++ C+DP  ++W   A MS+ R    +    G +YA+GG  
Sbjct: 560 LSGKLYAVGGRDGS-SCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHD 618

Query: 518 DHVDRCFDVLA--VEYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNWRLNNVT 575
                    L+  VE Y P+TD WT+V+ M   +   G CLL  K+Y VGGY+ +     
Sbjct: 619 APASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQA--YL 676

Query: 576 GIVQVYNTDTDEWERDLHFPESFAGIACAPVLLPRAG 612
             V+ Y+  T+EW +             AP+ L RAG
Sbjct: 677 NTVEAYDPQTNEWTQ------------VAPLCLGRAG 701


>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
          Length = 755

 Score =  260 bits (664), Expect = 3e-69
 Identities = 178/577 (30%), Positives = 274/577 (47%), Gaps = 30/577 (5%)

Query: 40  FSAPSHSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREA 99
           F A +H+    + +       QL DV+L       PAH++VL++ SDYF AMFT  +REA
Sbjct: 197 FQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREA 256

Query: 100 SQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAA 159
            Q+ I+++GV    L  +I +AY+  + L  D ++ +L  A  LQ+  VVE C +FL   
Sbjct: 257 RQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQ 316

Query: 160 MSVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQ 219
           +    CL I   A       L +    +T  HF+++   ++F+ LP   +   L S+ + 
Sbjct: 317 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMN 376

Query: 220 SCAEIDLFRAAVRWLQHD-PARRPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLCR 278
              E  +  A + W++HD   RR   S +L +IR PL+    L D    + +  +D+ C+
Sbjct: 377 IPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADMENNV-LFRDDIECQ 435

Query: 279 QYLLEAFNYQVLPFRQHEMQSPRTAVR-SDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPG 337
           + ++EA  Y +LP R+  +QSPRT  R S V +L   GG   T    S+    Y L    
Sbjct: 436 KLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEK--YDL---R 490

Query: 338 ARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQ 397
              +  +  M        VAVLD+ +YV GG     R G   ++    Y+P    W  + 
Sbjct: 491 TNMWTPVANMNGRRLQFGVAVLDDKLYVVGG-----RDGLKTLNTVECYNPKTKTWSVMP 545

Query: 398 AMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAGAA 457
            M   R    + VL G +YA GG +    L +VER+ P+  +W +  ++         A 
Sbjct: 546 PMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAV 605

Query: 458 SGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGRM 517
             G+LY  GG   S    K++ C+DP  ++W   A MS+ R    +    G +YA+GG  
Sbjct: 606 LSGKLYAVGGRDGS-SCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHD 664

Query: 518 DHVDRCFDVLA--VEYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNWRLNNVT 575
                    L+  VE Y P+TD WT+V+ M   +   G CLL  K+Y VGGY+ +     
Sbjct: 665 APASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQA--YL 722

Query: 576 GIVQVYNTDTDEWERDLHFPESFAGIACAPVLLPRAG 612
             V+ Y+  T+EW +             AP+ L RAG
Sbjct: 723 NTVEAYDPQTNEWTQ------------VAPLCLGRAG 747


>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
          Length = 597

 Score =  255 bits (651), Expect = 1e-67
 Identities = 173/573 (30%), Positives = 275/573 (47%), Gaps = 22/573 (3%)

Query: 22  GPERPNSTADKNGALKCTFSA-PSHSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVV 80
           G ++P  + D N    C  +  P H     + +  LR+Q  L DV +        AH+VV
Sbjct: 18  GHQKPLDSKDDNTEKHCPVTVNPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVV 77

Query: 81  LAACSDYFRAMFTGGMREASQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAA 140
           LAACS YF AMFTG M E+    + +K V    LR +ID+ Y+AE+ +  + VQ +L AA
Sbjct: 78  LAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAA 137

Query: 141 VFLQMLPVVELCEEFLKAAMSVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEED 200
             LQ+  V + C EFL++ +    CL I   A   +   L    + +  +HF  +   E+
Sbjct: 138 GLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEE 197

Query: 201 FLRLPLERLVFFLQSNRLQSCAEIDLFRAAVRWLQHD-PARRPRASHVLCHIRFPLMQSS 259
           FL L +E++   + S++L   +E  +F A + W+ HD   R+   + ++ H+R PL+   
Sbjct: 198 FLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPRE 257

Query: 260 ELVDSVQTLDIMVEDVLCRQYLLEAFNYQVLPFRQH-EMQSPRTAVRS--DVPSLVTFGG 316
            LV  V+   ++     C+ YL+EA  Y +LP  Q   M+S RT +R+  ++P L+   G
Sbjct: 258 YLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVG 317

Query: 317 TPYTDSDRSVSSKVYQLPEPGARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSG 376
                + RSV  + Y   E     + ++ E+        +  +   V+  GG      +G
Sbjct: 318 GQAPKAIRSV--ECYDFKE---ERWHQVAELPSRRCRAGMVYMAGLVFAVGG-----FNG 367

Query: 377 EGAVDACYRYDPHLNRWLRLQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPR 436
              V     YDP  ++W  +  M++ R      VL G++YA GG + +  L+SVE Y  +
Sbjct: 368 SLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIK 427

Query: 437 RNEWGYACSLKRRTWGHAGAASGGRLYISGGY-GISVEDKKALHCYDPVADQWEFKAPMS 495
            NEW +   +  R         GG LY  GGY G S +    + CY+   ++W + A MS
Sbjct: 428 SNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMS 487

Query: 496 EPRVLHAMVGAGGRIYALGGRMDHVDRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAGCC 555
             R    +      +YA+GG    + R     +VE Y P T+ W  V+ M   +  AG C
Sbjct: 488 TRRSGAGVGVLNNLLYAVGGHDGPLVR----KSVEVYDPTTNAWRQVADMNMCRRNAGVC 543

Query: 556 LLERKIYIVGGYNWRLNNVTGIVQVYNTDTDEW 588
            +   +Y+VGG +   N  +  V+ YN  TD+W
Sbjct: 544 AVNGLLYVVGGDDGSCNLAS--VEYYNPTTDKW 574



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 45/175 (25%), Positives = 72/175 (41%), Gaps = 7/175 (4%)

Query: 282 LEAFNYQVLP-FRQHEMQSPRTAVRSDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPGARH 340
           +EA+N +    F    M + R++V   V   + +    Y  + R   S V +        
Sbjct: 421 VEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTV-ECYNATTNE 479

Query: 341 FRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQAMQ 400
           +  + EM    S   V VL+N +Y  GG       G     +   YDP  N W ++  M 
Sbjct: 480 WTYIAEMSTRRSGAGVGVLNNLLYAVGGH-----DGPLVRKSVEVYDPTTNAWRQVADMN 534

Query: 401 ESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAG 455
             R    +  + G++Y  GG + + +LASVE Y P  ++W    S       +AG
Sbjct: 535 MCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAG 589


>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
          Length = 593

 Score =  255 bits (651), Expect = 1e-67
 Identities = 173/573 (30%), Positives = 275/573 (47%), Gaps = 22/573 (3%)

Query: 22  GPERPNSTADKNGALKCTFSA-PSHSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVV 80
           G ++P  + D N    C  +  P H     + +  LR+Q  L DV +        AH+VV
Sbjct: 14  GHQKPLDSKDDNTEKHCPVTVNPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVV 73

Query: 81  LAACSDYFRAMFTGGMREASQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAA 140
           LAACS YF AMFTG M E+    + +K V    LR +ID+ Y+AE+ +  + VQ +L AA
Sbjct: 74  LAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAA 133

Query: 141 VFLQMLPVVELCEEFLKAAMSVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEED 200
             LQ+  V + C EFL++ +    CL I   A   +   L    + +  +HF  +   E+
Sbjct: 134 GLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEE 193

Query: 201 FLRLPLERLVFFLQSNRLQSCAEIDLFRAAVRWLQHD-PARRPRASHVLCHIRFPLMQSS 259
           FL L +E++   + S++L   +E  +F A + W+ HD   R+   + ++ H+R PL+   
Sbjct: 194 FLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPRE 253

Query: 260 ELVDSVQTLDIMVEDVLCRQYLLEAFNYQVLPFRQH-EMQSPRTAVRS--DVPSLVTFGG 316
            LV  V+   ++     C+ YL+EA  Y +LP  Q   M+S RT +R+  ++P L+   G
Sbjct: 254 YLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVG 313

Query: 317 TPYTDSDRSVSSKVYQLPEPGARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSG 376
                + RSV  + Y   E     + ++ E+        +  +   V+  GG      +G
Sbjct: 314 GQAPKAIRSV--ECYDFKE---ERWHQVAELPSRRCRAGMVYMAGLVFAVGG-----FNG 363

Query: 377 EGAVDACYRYDPHLNRWLRLQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPR 436
              V     YDP  ++W  +  M++ R      VL G++YA GG + +  L+SVE Y  +
Sbjct: 364 SLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIK 423

Query: 437 RNEWGYACSLKRRTWGHAGAASGGRLYISGGY-GISVEDKKALHCYDPVADQWEFKAPMS 495
            NEW +   +  R         GG LY  GGY G S +    + CY+   ++W + A MS
Sbjct: 424 SNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMS 483

Query: 496 EPRVLHAMVGAGGRIYALGGRMDHVDRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAGCC 555
             R    +      +YA+GG    + R     +VE Y P T+ W  V+ M   +  AG C
Sbjct: 484 TRRSGAGVGVLNNLLYAVGGHDGPLVR----KSVEVYDPTTNAWRQVADMNMCRRNAGVC 539

Query: 556 LLERKIYIVGGYNWRLNNVTGIVQVYNTDTDEW 588
            +   +Y+VGG +   N  +  V+ YN  TD+W
Sbjct: 540 AVNGLLYVVGGDDGSCNLAS--VEYYNPTTDKW 570



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 45/175 (25%), Positives = 72/175 (41%), Gaps = 7/175 (4%)

Query: 282 LEAFNYQVLP-FRQHEMQSPRTAVRSDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPGARH 340
           +EA+N +    F    M + R++V   V   + +    Y  + R   S V +        
Sbjct: 417 VEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTV-ECYNATTNE 475

Query: 341 FRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQAMQ 400
           +  + EM    S   V VL+N +Y  GG       G     +   YDP  N W ++  M 
Sbjct: 476 WTYIAEMSTRRSGAGVGVLNNLLYAVGGH-----DGPLVRKSVEVYDPTTNAWRQVADMN 530

Query: 401 ESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAG 455
             R    +  + G++Y  GG + + +LASVE Y P  ++W    S       +AG
Sbjct: 531 MCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAG 585


>gi|14780904 kelch-like 1 protein [Homo sapiens]
          Length = 748

 Score =  253 bits (647), Expect = 3e-67
 Identities = 186/617 (30%), Positives = 299/617 (48%), Gaps = 36/617 (5%)

Query: 3   ESGGSSGGAGGGGAFGAGPGPERPNSTADKNGALKCTFSAPSHSTSLLQGLATLRAQGQL 62
           ++   + G G G    +      P S  D + + +  + A  H+    + + +   Q QL
Sbjct: 153 DNSSQATGEGCGHRLSSTGHSMTPQSDLDSSSSEEF-YQAVHHAEQTFRKMESYLKQQQL 211

Query: 63  LDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREASQDVIELKGVSARGLRHIIDFAY 122
            DV+L +     PAH++VL++ SDYF AMFT  + EA Q+ I+++G+    L  ++ FAY
Sbjct: 212 CDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAY 271

Query: 123 SAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMSVETCLNIGQMATTFSLASLRE 182
           +  + L  D ++++L AA  LQ+  VVE+C  FL   +    CL I   A       L +
Sbjct: 272 TGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMK 331

Query: 183 SVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQSCAEIDLFRAAVRWLQHD-PARR 241
              ++T  + +++   ++FL LP E L   L S+ +    E  +F A + W+++D  +R 
Sbjct: 332 VAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQSRC 391

Query: 242 PRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLCRQYLLEAFNYQVLPFRQHEMQSPR 301
              S +L  IR PL+    L D ++   +   D+ C++ +LEA  Y +LP R+  MQSPR
Sbjct: 392 NDLSMLLAFIRLPLLPPQILAD-LENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPR 450

Query: 302 TAVR-SDVPSLVTFGGTPYTDSDRSVSS-KVYQLP-----EPGARHFRELTEMEVGCSHT 354
           T  R S V +L   GG    D+++  ++ + Y L      + G  + R L   + G    
Sbjct: 451 TKPRKSTVGTLYAVGG---MDNNKGATTIEKYDLRTNLWIQAGMMNGRRL---QFG---- 500

Query: 355 CVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQAMQESRIQFQLNVLCGM 414
            VAV+D+ ++V GG     R G   ++    Y+P    W  L  M   R    + VL G 
Sbjct: 501 -VAVIDDKLFVIGG-----RDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGP 554

Query: 415 VYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAGAASGGRLYISGGYGISVED 474
           +YA GG +    L +VER+ P+  +W +  S+         AA  G+LY  GG   S   
Sbjct: 555 IYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGS-SC 613

Query: 475 KKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGR----MDHVDRCFDVLAVE 530
             ++  YDP  ++W   APM + R    +    G +YA+GG      +H  R  D   VE
Sbjct: 614 LSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDY--VE 671

Query: 531 YYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNWRLNNVTGIVQVYNTDTDEWER 590
            Y P+TD WT V+P+   +   G CLL  ++Y VGGY+ +       ++ Y+  T+EW +
Sbjct: 672 RYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQ--TYLNTMESYDPQTNEWTQ 729

Query: 591 DLHFPESFAGIACAPVL 607
                   AG AC  V+
Sbjct: 730 MASLNIGRAG-ACVVVI 745


>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
          Length = 718

 Score =  249 bits (637), Expect = 4e-66
 Identities = 170/578 (29%), Positives = 271/578 (46%), Gaps = 26/578 (4%)

Query: 40  FSAPSHSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREA 99
           F   +H+   L+ +     + QL DV+L       PAH++VL+A SDYF AMFT  + EA
Sbjct: 159 FHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEA 218

Query: 100 SQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAA 159
            Q+ + ++GV    L  ++ +AY+  + L  D ++ +L AA  LQ+  V+++C  FL   
Sbjct: 219 KQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQ 278

Query: 160 MSVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQ 219
           +    CL I           L      +T  HF+++ + ++FL LP   +   L S+ + 
Sbjct: 279 LHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDIN 338

Query: 220 SCAEIDLFRAAVRWLQHD-PARRPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLCR 278
              E  +F A ++W+ HD   R+     +L +IR PL+    L D ++T  +   D+ C+
Sbjct: 339 VPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLECQ 397

Query: 279 QYLLEAFNYQVLPFRQHEMQSPRTAVR-SDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPG 337
           + L+EA  Y +LP R+  MQSPRT  R S V +L   GG        ++    Y L    
Sbjct: 398 KLLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEK--YDLRTNS 455

Query: 338 ARHFRELT--EMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLR 395
             H   +    ++ G     VAV+DN +YV GG     R G   ++    ++P    W  
Sbjct: 456 WLHIGTMNGRRLQFG-----VAVIDNKLYVVGG-----RDGLKTLNTVECFNPVGKIWTV 505

Query: 396 LQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAG 455
           +  M   R    +  L G +YA GG +    L +VER+ P   +W Y  S+         
Sbjct: 506 MPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGV 565

Query: 456 AASGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGG 515
            A   +LY  GG   S    K++  +DP  ++W   APMS+ R    +    G +Y +GG
Sbjct: 566 VALNNKLYAIGGRDGS-SCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGG 624

Query: 516 R----MDHVDRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNWRL 571
                 +H  R  D   VE Y P+ D W++V+P+   +     C L  K+Y+VGGY+   
Sbjct: 625 HDAPASNHCSRLSD--CVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDG-- 680

Query: 572 NNVTGIVQVYNTDTDEWERDLHFPESFAGIACAPVLLP 609
           +     V+ Y+   +EW+ ++      AG     V LP
Sbjct: 681 HTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVVVKLP 718


>gi|55925604 kelch-like 18 [Homo sapiens]
          Length = 574

 Score =  249 bits (636), Expect = 5e-66
 Identities = 167/557 (29%), Positives = 267/557 (47%), Gaps = 20/557 (3%)

Query: 56  LRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREASQDVIELKGVSARGLR 115
           +R QG+L DV L I    F AH++VLAA   YF AMFT  M E  QD I ++G+    L 
Sbjct: 31  IRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALE 90

Query: 116 HIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMSVETCLNIGQMATTF 175
            +I+FAY+  + +D   VQ +L  A FLQ+  + + C  FL+  +  + CL + Q A T 
Sbjct: 91  ALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFAETM 150

Query: 176 SLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQSCAEIDLFRAAVRWLQ 235
             A L ++ ++F  +HF++++  E+FL LPLE ++  +  + L   +E  +F AA+ W++
Sbjct: 151 MCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVR 210

Query: 236 HDPARR-PRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLCRQYLLEAFNYQVLPFRQ 294
           +D  +R P    +L +IR PL +   L D VQ  D++     CR  + EA +Y ++P R+
Sbjct: 211 YDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMPERR 270

Query: 295 HEMQSPRTAVR--SDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPGARHFRELTEMEVGCS 352
             + + RT  R  + +  L+   G   +  D   S  V ++ +P A  +     M    S
Sbjct: 271 PHLPAFRTRPRCCTSIAGLIYAVGGLNSAGD---SLNVVEVFDPIANCWERCRPMTTARS 327

Query: 353 HTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQAMQESRIQFQLNVLC 412
              VAV++  +Y  GG   Q R     +     Y+P  + W R+ +M   R      VL 
Sbjct: 328 RVGVAVVNGLLYAIGGYDGQLR-----LSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLD 382

Query: 413 GMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAGAASGGRLYISGGYGISV 472
           G +Y  GG +   SL+SVE Y P  ++W    S+             GR+Y+SGG+   +
Sbjct: 383 GQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHD-GL 441

Query: 473 EDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGRMDHVDRCFDVLAVEYY 532
           +   ++  Y+     W   A M   R  H     G +++  GG     D    +   E Y
Sbjct: 442 QIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGG----YDGSGFLSIAEMY 497

Query: 533 VPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNWRLNNVTGIVQVYNTDTDEWE--R 590
               DQW  + PM   +S         ++Y VGGY+ + N     V++Y+ +TD W    
Sbjct: 498 SSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSN--LSSVEMYDPETDCWTFMA 555

Query: 591 DLHFPESFAGIACAPVL 607
            +   E   G+ C P+L
Sbjct: 556 PMACHEGGVGVGCIPLL 572


>gi|166235129 kelch-like 3 [Homo sapiens]
          Length = 587

 Score =  248 bits (634), Expect = 9e-66
 Identities = 171/568 (30%), Positives = 281/568 (49%), Gaps = 24/568 (4%)

Query: 43  PSHSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREASQD 102
           P+H     + +  LR++  L DV++        AH+VVLAACS YF AMFTG M E+   
Sbjct: 30  PAHMGKAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAK 89

Query: 103 VIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMSV 162
            IE+K V  + L  +ID+ Y+AE+ +  + VQ +L AA  LQ++ V + C +FL++ +  
Sbjct: 90  KIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHP 149

Query: 163 ETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQSCA 222
             CL I   A   +   L +  +A+  +HF ++   E+FL L L+++   + S++L   +
Sbjct: 150 TNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSS 209

Query: 223 EIDLFRAAVRWLQHD-PARRPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLCRQYL 281
           E  +F A + W+ ++   R    + ++ H+R PL+    LV +V+   ++  +  C+ +L
Sbjct: 210 EEKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFL 269

Query: 282 LEAFNYQVLPFRQHEM-QSPRTAVRSDV--PSLVTFGGTPYTDSDRSVSSKVYQLPEPGA 338
           +EA  Y +LP  Q  + ++PRT  R+ V  P ++   G     + RSV  + Y   E   
Sbjct: 270 IEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSV--ECYDFEED-- 325

Query: 339 RHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQA 398
             + ++ E+        V  +   VY  GG      +G   V     YD   ++W  + +
Sbjct: 326 -RWDQIAELPSRRCRAGVVFMAGHVYAVGG-----FNGSLRVRTVDVYDGVKDQWTSIAS 379

Query: 399 MQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAGAAS 458
           MQE R      VL  ++YA GG + +  LASVE Y  + NEW +   +  R         
Sbjct: 380 MQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVV 439

Query: 459 GGRLYISGGY-GISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGRM 517
            G+LY  GGY G S +    +  Y+P  ++W + A MS  R    +    G++YA GG  
Sbjct: 440 EGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHD 499

Query: 518 DHVDRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNWRLNNVTGI 577
             + R     +VE Y P T+ W  V+ M   +  AG C +   +Y+VGG +   N  +  
Sbjct: 500 GPLVR----KSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLAS-- 553

Query: 578 VQVYNTDTDEW---ERDLHFPESFAGIA 602
           V+ YN  TD+W     ++    S+AG+A
Sbjct: 554 VEYYNPVTDKWTLLPTNMSTGRSYAGVA 581


>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
          Length = 720

 Score =  246 bits (628), Expect = 4e-65
 Identities = 165/561 (29%), Positives = 265/561 (47%), Gaps = 26/561 (4%)

Query: 40  FSAPSHSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREA 99
           F   +H+   L+ +     + QL DV+L       PAH++VL+A SDYF AMFT  + EA
Sbjct: 159 FHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEA 218

Query: 100 SQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAA 159
            Q+ + ++GV    L  ++ +AY+  + L  D ++ +L AA  LQ+  V+++C  FL   
Sbjct: 219 KQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQ 278

Query: 160 MSVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQ 219
           +    CL I           L      +T  HF+++ + ++FL LP   +   L S+ + 
Sbjct: 279 LHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDIN 338

Query: 220 SCAEIDLFRAAVRWLQHD-PARRPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLCR 278
              E  +F A ++W+ HD   R+     +L +IR PL+    L D ++T  +   D+ C+
Sbjct: 339 VPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLECQ 397

Query: 279 QYLLEAFNYQVLPFRQHEMQSPRTAVR-SDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPG 337
           + L+EA  Y +LP R+  MQSPRT  R S V +L   GG        ++    Y L    
Sbjct: 398 KLLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEK--YDLRTNS 455

Query: 338 ARHFRELT--EMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLR 395
             H   +    ++ G     VAV+DN +YV GG     R G   ++    ++P    W  
Sbjct: 456 WLHIGTMNGRRLQFG-----VAVIDNKLYVVGG-----RDGLKTLNTVECFNPVGKIWTV 505

Query: 396 LQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAG 455
           +  M   R    +  L G +YA GG +    L +VER+ P   +W Y  S+         
Sbjct: 506 MPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGV 565

Query: 456 AASGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGG 515
            A   +LY  GG   S    K++  +DP  ++W   APMS+ R    +    G +Y +GG
Sbjct: 566 VALNNKLYAIGGRDGS-SCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGG 624

Query: 516 R----MDHVDRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNWRL 571
                 +H  R  D   VE Y P+ D W++V+P+   +     C L  K+Y+VGGY+   
Sbjct: 625 HDAPASNHCSRLSD--CVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDG-- 680

Query: 572 NNVTGIVQVYNTDTDEWERDL 592
           +     V+ Y+   +EW+  +
Sbjct: 681 HTYLNTVESYDAQRNEWKESM 701


>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
          Length = 694

 Score =  241 bits (615), Expect = 1e-63
 Identities = 167/539 (30%), Positives = 258/539 (47%), Gaps = 30/539 (5%)

Query: 78  KVVLAACSDYFRAMFTGGMREASQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVL 137
           ++VL++ SDYF AMFT  +REA Q+ I+++GV    L  +I +AY+  + L  D ++ +L
Sbjct: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233

Query: 138 GAAVFLQMLPVVELCEEFLKAAMSVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAE 197
             A  LQ+  VVE C +FL   +    CL I   A       L +    +T  HF+++  
Sbjct: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293

Query: 198 EEDFLRLPLERLVFFLQSNRLQSCAEIDLFRAAVRWLQHD-PARRPRASHVLCHIRFPLM 256
            ++F+ LP   +   L S+ +    E  +  A + W++HD   RR   S +L +IR PL+
Sbjct: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353

Query: 257 QSSELVDSVQTLDIMVEDVLCRQYLLEAFNYQVLPFRQHEMQSPRTAVR-SDVPSLVTFG 315
               L D    + +  +D+ C++ ++EA  Y +LP R+  +QSPRT  R S V +L   G
Sbjct: 354 APQFLADMENNV-LFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVG 412

Query: 316 GTPYTDSDRSVSSKVYQLPEPGARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRS 375
           G   T    S+    Y L       +  +  M        VAVLD+ +YV GG     R 
Sbjct: 413 GMDSTKGATSIEK--YDL---RTNMWTPVANMNGRRLQFGVAVLDDKLYVVGG-----RD 462

Query: 376 GEGAVDACYRYDPHLNRWLRLQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCP 435
           G   ++    Y+P    W  +  M   R    + VL G +YA GG +    L +VER+ P
Sbjct: 463 GLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDP 522

Query: 436 RRNEWGYACSLKRRTWGHAGAASGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMS 495
           +  +W +  ++         A   G+LY  GG   S    K++ C+DP  ++W   A MS
Sbjct: 523 QARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGS-SCLKSVECFDPHTNKWTLCAQMS 581

Query: 496 EPRVLHAMVGAGGRIYALGGRMDHVDRCFDVLA--VEYYVPETDQWTSVSPMRAGQSEAG 553
           + R    +    G +YA+GG           L+  VE Y P+TD WT+V+ M   +   G
Sbjct: 582 KRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVG 641

Query: 554 CCLLERKIYIVGGYNWRLNNVTGIVQVYNTDTDEWERDLHFPESFAGIACAPVLLPRAG 612
            CLL  K+Y VGGY+ +       V+ Y+  T+EW +             AP+ L RAG
Sbjct: 642 VCLLGDKLYAVGGYDGQA--YLNTVEAYDPQTNEWTQ------------VAPLCLGRAG 686


>gi|23397572 kelch-like 34 [Homo sapiens]
          Length = 644

 Score =  228 bits (581), Expect = 1e-59
 Identities = 182/630 (28%), Positives = 274/630 (43%), Gaps = 73/630 (11%)

Query: 44  SHSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREASQDV 103
           +H  +LL G   LRA+G L DV L      FPAH+ +LA  SDYFRA+F    +E+   V
Sbjct: 10  AHGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARV 69

Query: 104 IELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMSVE 163
           I L   SA GL+ ++DF Y+A ++L +D V+D L AA +LQ+   + LC  +L+  ++ E
Sbjct: 70  IHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPE 129

Query: 164 TCLNIGQMATTFSLASLRESVDAFTFRHFLQI----AEEEDFLRLPLERLVFFLQSNRLQ 219
            C     +A  F LA   ++ +     H  ++    A     L L    L   L +  + 
Sbjct: 130 NCCFAANVAARFGLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDVA 189

Query: 220 SCAEIDLFRAAVRWLQHDPA--RRPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLC 277
              E  L   A+ WL+ +P   R    + +L  +RF L+  ++++  V +   +V     
Sbjct: 190 RVPEARLLGLALAWLRQEPTTERLAHCTELLERVRFGLV-PADVLRRVYSGSGLVLPARV 248

Query: 278 RQYLLEAFNYQVLPFRQHEMQSPRTAVRSDVPSLVTFGGTPYTD--------SDRSVSSK 329
           +  +++A NY   P RQ  MQ  +T++RS    ++  GG    +          R+   +
Sbjct: 249 KGLIIQALNYHTTPSRQPLMQGEQTSIRSPQTRILLVGGRRAREVVIEEVAAPQRAARGQ 308

Query: 330 VYQLPEPGA---------------------------RHFRELTEMEVGCSHTCVAVLDNF 362
           V   PEP                               +R LT++        V    NF
Sbjct: 309 V-AAPEPEEEEEELEEEEEEEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNF 367

Query: 363 VYVAGGQHLQYRSGEGAVD-------ACYRYDPHLNRWLRLQAMQESRIQFQLNVLCGMV 415
           ++V GG+     +     D         +RYDP  + W  + AM+E+R  F    +   +
Sbjct: 368 LFVLGGESPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERL 427

Query: 416 YATGGRNRAGS-LASVERYCPRRNEWGYACSLKRRTWGHAGAASG-GRLYISGGYGISVE 473
            A GG    G  LASVE Y  RR+ W  A +L R   GHAGA    G +YISGG     E
Sbjct: 428 LAVGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGKAGRGE 487

Query: 474 ----DKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGRMDHVDRCFDVLAV 529
                 + L+   P    W  KAPM   R  H M    G ++A  GR +          +
Sbjct: 488 GGASSLRDLYVLGPEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLGRYEPFSE------I 541

Query: 530 EYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNWR------LNNVTGIVQVYNT 583
           E Y P  DQWT + P+   +   G  ++E    ++GG  WR        NV G    Y+ 
Sbjct: 542 ERYDPGADQWTRLRPLPYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVG----YDL 597

Query: 584 DTDEWER-DLHFPESFAGIACAPVLLPRAG 612
           D D WE      P +++G+ CA + L   G
Sbjct: 598 DLDRWEDIGCALPWAWSGLRCAVLQLAEGG 627


>gi|38194229 kelch-like 17 [Homo sapiens]
          Length = 642

 Score =  228 bits (581), Expect = 1e-59
 Identities = 161/562 (28%), Positives = 264/562 (46%), Gaps = 60/562 (10%)

Query: 45  HSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREASQDVI 104
           H       ++ +R +G L D+VL +  +   AHKVVLA+CS YF AMFT  M E+ Q  +
Sbjct: 74  HYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHV 133

Query: 105 ELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMSVET 164
            L  +  + L  ++ FAY+AE+ +    VQ +L AA  LQ+  V + C +FL + +    
Sbjct: 134 TLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSN 193

Query: 165 CLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQSCAEI 224
           CL I   A   S + L ++   +  +HF+ +A+ E+F+ LPL++++  + S+ L   +E 
Sbjct: 194 CLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEE 253

Query: 225 DLFRAAVRWLQHD-PARRPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLCRQYLLE 283
           +++RA + W++HD  ARR     ++  +R PL+    L+  V    ++     C+  L+E
Sbjct: 254 EVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIE 313

Query: 284 AFNYQVLPFRQHEMQSPRTAVR---SDVPSLVTFGGTPY-----------TDSDR----- 324
           A  + +LP ++  + + RT  R      P L   GG              T +DR     
Sbjct: 314 ALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVVA 373

Query: 325 ------------SVSSKVYQLP--------------EPGARHFRELTEMEVGCSHTC--V 356
                       +V +++Y +               +P    ++   E+ +G   +C  V
Sbjct: 374 SMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQ--PEVSMGTRRSCLGV 431

Query: 357 AVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQAMQESRIQFQLNVLCGMVY 416
           A L   +Y AGG       G   +++  RYDP    W  + AM   R   ++  L G +Y
Sbjct: 432 AALHGLLYSAGGY-----DGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLY 486

Query: 417 ATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAGAASGGRLYISGGYGISVEDKK 476
           A GG + +  LA+VE+Y P+ N W    S+  R      A   G LY++GG         
Sbjct: 487 AVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGG-NDGTSCLN 545

Query: 477 ALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGRMDHVDRCFDVLAVEYYVPET 536
           ++  Y P A  WE  APM+  R  H +V   G +YA+GG     D    + ++E Y P T
Sbjct: 546 SVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGN----DGSSSLNSIEKYNPRT 601

Query: 537 DQWTSVSPMRAGQSEAGCCLLE 558
           ++W + S M   +S  G  +LE
Sbjct: 602 NKWVAASCMFTRRSSVGVAVLE 623


>gi|11056006 kelch-like 12 [Homo sapiens]
          Length = 568

 Score =  224 bits (572), Expect = 1e-58
 Identities = 148/549 (26%), Positives = 261/549 (47%), Gaps = 17/549 (3%)

Query: 44  SHSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREASQDV 103
           +H+ S+L  + +LR    L DV L + ++ FPAH++VLAACSDYF AMFT  + E  +  
Sbjct: 14  THAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPY 73

Query: 104 IELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMSVE 163
           ++++G++A  +  ++DF Y+  V + ++ VQ++L AA  LQ+  V + C EFL++ +   
Sbjct: 74  VDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPS 133

Query: 164 TCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQSCAE 223
            CL I   A T +   L ++ + F+ +HF ++ + E+F+ L    +   ++ + +Q  +E
Sbjct: 134 NCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSE 193

Query: 224 IDLFRAAVRWLQHDPARRPRA-SHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLCRQYLL 282
             +F A + W++H    R  +  ++L ++R PL+    + D +     +   + CR  + 
Sbjct: 194 EPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVD 253

Query: 283 EAFNYQVLPFRQHEMQSPRTAVRSDVPS-LVTFGGTPYTDSDRSVSSKVYQLPEPGARHF 341
           EA  + + P  + +MQ PRT  R      L+  GG     S   V  K     +P  + +
Sbjct: 254 EAKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKY----DPKTQEW 309

Query: 342 RELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQAMQE 401
             L  +     +     L + +YV GG     RS   +V+           W  +  M  
Sbjct: 310 SFLPSITRKRRYVASVSLHDRIYVIGG--YDGRSRLSSVECLDYTADEDGVWYSVAPMNV 367

Query: 402 SRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAGAASGGR 461
            R       L  M+Y +GG + +    S+ERY P  ++W     ++    G     + G 
Sbjct: 368 RRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGV 427

Query: 462 LYISGGY-GISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGRMDHV 520
           +Y  GGY G+++    ++  YDP    W    PM+  R    +      IY +GG     
Sbjct: 428 IYCLGGYDGLNI--LNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGG----F 481

Query: 521 DRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNWRLNNVTGIVQV 580
           D    + +VE Y   TD WT+V+ M   +   G  +L  ++Y + GY+   N++   ++ 
Sbjct: 482 DGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDG--NSLLSSIEC 539

Query: 581 YNTDTDEWE 589
           Y+   D WE
Sbjct: 540 YDPIIDSWE 548



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 30/112 (26%), Positives = 49/112 (43%), Gaps = 5/112 (4%)

Query: 335 EPGARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWL 394
           +P   H+  +T M    S   VA+L++ +YV GG       G   + +   Y+   + W 
Sbjct: 447 DPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGF-----DGTAHLSSVEAYNIRTDSWT 501

Query: 395 RLQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSL 446
            + +M   R      VL G +YA  G +    L+S+E Y P  + W    S+
Sbjct: 502 TVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSM 553


>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
          Length = 571

 Score =  223 bits (568), Expect = 4e-58
 Identities = 157/554 (28%), Positives = 258/554 (46%), Gaps = 27/554 (4%)

Query: 45  HSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREASQDVI 104
           HS  LLQGL  LR   +L D++L +      AHKVVLA+ S YF+AMFTG + E     +
Sbjct: 17  HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEV 76

Query: 105 ELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMSVET 164
           E + +    L+ I+++AY+  V +  D V+ +L AA  LQ+  V++ C  FL++ +    
Sbjct: 77  EFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGN 136

Query: 165 CLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQSCAEI 224
           C+ I + A T+    L  +   +  ++F  + + E+F  L    L   + ++ L    E 
Sbjct: 137 CIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEE 196

Query: 225 DLFRAAVRWLQHDPARRPR-ASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLCRQYLLE 283
            +F A   W+++D   R +  + +L  +R PL+    L    +   ++ +D  C+  L E
Sbjct: 197 TVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNE 256

Query: 284 AFNYQVLPFRQHEMQSP-RTAVRSDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPGARHFR 342
           A  Y  +P  +   Q+   T  R     L   GG     S         ++  P    + 
Sbjct: 257 ALKYHFMPEHRLSHQTVLMTRPRCAPKVLCAVGG----KSGLFACLDSVEMYFPQNDSWI 312

Query: 343 ELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSG------EGAVDACYRYDPHLNRWLRL 396
            L  + +      + VLD  VYV GG     R G      E +V+    ++P  N W  L
Sbjct: 313 GLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVEC---WNPDTNTWTSL 369

Query: 397 QAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAGA 456
           + M ESR    + VL G +YA GG +    L SVE+Y P+  +W     +       A A
Sbjct: 370 ERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAA 429

Query: 457 ASGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGR 516
              G +Y  GGYG +     ++  YDP  D WE  A M++ R+   +    G I+ +GG 
Sbjct: 430 VLDGMIYAIGGYGPA--HMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGH 487

Query: 517 --MDHVDRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNWRLNNV 574
             + H+       ++E Y P  +QWT   PM+  ++  G  +++  +Y+VGG++   ++ 
Sbjct: 488 NGVSHLS------SIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSG--SSY 539

Query: 575 TGIVQVYNTDTDEW 588
              VQ Y+  +D W
Sbjct: 540 LNTVQKYDPISDTW 553



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 49/159 (30%), Positives = 74/159 (46%), Gaps = 7/159 (4%)

Query: 336 PGARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLR 395
           P  R ++ +  M    S    AVLD  +Y  GG       G   +++  RYDP  + W  
Sbjct: 408 PKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGY------GPAHMNSVERYDPSKDSWEM 461

Query: 396 LQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAG 455
           + +M + RI F + V+ G ++  GG N    L+S+ERY P +N+W     +K    G   
Sbjct: 462 VASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGA 521

Query: 456 AASGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPM 494
           A     LY+ GG+  S      +  YDP++D W   A M
Sbjct: 522 AVIDNYLYVVGGHSGS-SYLNTVQKYDPISDTWLDSAGM 559



 Score = 36.6 bits (83), Expect = 0.070
 Identities = 20/55 (36%), Positives = 27/55 (49%), Gaps = 5/55 (9%)

Query: 357 AVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQAMQESRIQFQLNVL 411
           AV+DN++YV GG      SG   ++   +YDP  + WL    M   R  F L  L
Sbjct: 522 AVIDNYLYVVGGH-----SGSSYLNTVQKYDPISDTWLDSAGMIYCRCNFGLTAL 571


>gi|109150407 kelch-like 6 [Homo sapiens]
          Length = 621

 Score =  221 bits (564), Expect = 1e-57
 Identities = 177/602 (29%), Positives = 286/602 (47%), Gaps = 56/602 (9%)

Query: 20  GPGPERPNSTADKNGAL-------KCTFSAPSHSTSLLQGLATLRAQGQLLDVVLTINRE 72
           GP     +  + K G L       K  F     S  L  GL TLR +  L DV+L ++ +
Sbjct: 22  GPLAPSTDEPSQKTGDLVEILNGEKVKFDDAGLSLILQNGLETLRMENALTDVILCVDIQ 81

Query: 73  AFPAHKVVLAACSDYFRAMFTGGMREASQDVIELKGVSARGLRHIIDFAYSAEVTLDLDC 132
            F  H+VVLAA S+YFRAMF   ++E  +  I +KGV A  +  ++D+ Y+++  +    
Sbjct: 82  EFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAETMHTLLDYTYTSKALITKQN 141

Query: 133 VQDVLGAAVFLQMLPVVELCEEFLKAAMSVETCLNIGQMATTFSLASLRESVDAFTFRHF 192
           VQ VL AA   Q L +V+ C  FL  A++ E C+ I ++A T SL SL++ V ++  ++F
Sbjct: 142 VQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLADTHSLDSLKKQVQSYIIQNF 201

Query: 193 LQIAEEEDFLRLPLERLVFFLQSNRLQSCAEIDLFRAAVRWLQHDPARR-PRASHVLCHI 251
           +QI   E+FL LP++ L   L+S+ L    E  +F   + W++H P+ R     +VL ++
Sbjct: 202 VQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMSWVRHKPSERLCLLPYVLENV 261

Query: 252 RFPLMQSSELVDSVQTLDIMVEDVLCRQYLLEAFNYQVLPFRQHEMQSPRTAVR-----S 306
           R PL+     V++V+   ++ +       L EA  Y +     +E+ S RT  R     S
Sbjct: 262 RLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHL---SGNEIISERTKPRMHEFQS 318

Query: 307 DVPSLVTFGGTPYTDSDRSVS----------SKVYQLPEPGARHFRELTEMEVGCSHTCV 356
           +V   +  GG   T  +R V+          S++     P   H  E +E +      CV
Sbjct: 319 EV--FMIIGGC--TKDERFVAEVTCLDPLRRSRLEVAKLPLTEHELE-SENKKWVEFACV 373

Query: 357 AVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQAMQESRIQFQLNVLCGMVY 416
             L N VY++GG+  Q+          ++Y+  +N+W++++ +   R + ++ VL G VY
Sbjct: 374 -TLKNEVYISGGKETQH--------DVWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVY 424

Query: 417 ATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAGAASGGRLYISGG--YGISVED 474
             GG +    + +VE Y P  N W  A  L       A  +   +LY+ GG   G    D
Sbjct: 425 VIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGKLATD 484

Query: 475 KKALHCYDPVADQWEFKAPMS-EPRVLHAMVGAGGRIYALGGRMDHVDRCFDVLAVEYYV 533
           K    CYDP  ++W  KA M  E + ++A V    RIY +GG M          A+  Y 
Sbjct: 485 K--TQCYDPSTNKWSLKAAMPVEAKCINA-VSFRDRIYVVGGAM---------RALYAYS 532

Query: 534 PETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNWRLNNVTGIVQVYNTDTDEWERDLH 593
           P  D W  V+ +   ++  G      ++YI GG + + N V   V  ++ +  +   +  
Sbjct: 533 PLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEK-NEVIATVLCWDPEAQKLTEECV 591

Query: 594 FP 595
            P
Sbjct: 592 LP 593


>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
          Length = 624

 Score =  217 bits (553), Expect = 2e-56
 Identities = 159/590 (26%), Positives = 263/590 (44%), Gaps = 29/590 (4%)

Query: 29  TADKNGALKCTFSAPSHSTSLLQGLATLRAQGQLLDVVLTINREAFPA-----HKVVLAA 83
           T  ++G    +++   H+      +  LR   QL DV L +  +  PA     HKVVLA+
Sbjct: 43  TPSQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLAS 102

Query: 84  CSDYFRAMFTGGMREASQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFL 143
            S  F+AMFT G+RE   +V+ ++G+  + +  +I+FAY+A +++   CV  V+  AV  
Sbjct: 103 SSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMY 162

Query: 144 QMLPVVELCEEFLKAAMSVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLR 203
           Q+  VV  C +FL   +     + I   A       L +    + + HF ++A++E+F  
Sbjct: 163 QIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFN 222

Query: 204 LPLERLVFFLQSNRLQSCAEIDLFRAAVRWLQHD-PARRPRASHVLCHIRFPLMQSSELV 262
           L   +LV  +  + L    E ++F A + W+++D   RR     +L  +R   +  + L 
Sbjct: 223 LSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQ 282

Query: 263 DSVQTLDIMVEDVLCRQYLLEAFNYQVLPFRQHEMQSPRTAVRSDVPSLVTFGGTPYTDS 322
             +Q  +I+  D  C+ YL++        F +  +  P   +    P +   G   YT  
Sbjct: 283 MQLQKCEILQSDSRCKDYLVKI-------FEELTLHKPTQVMPCRAPKV---GRLIYTAG 332

Query: 323 DRSVSSKVY-QLPEPGARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVD 381
                S  Y +   P    +  L +++V  S     V+   +Y  GG++    S +G  D
Sbjct: 333 GYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRN---NSPDGNTD 389

Query: 382 --ACYRYDPHLNRWLRLQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNE 439
             A   Y+P  N+W     M   R +  + V+ G +YA GG +      SVERY P R+E
Sbjct: 390 SSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDE 449

Query: 440 WGYACSLKRRTWGHAGAASGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRV 499
           W     +  R  G   A     LY  GG+        +  CY P  ++W     M+  R 
Sbjct: 450 WHLVAPMLTRRIGVGVAVLNRLLYAVGGFD-GTNRLNSAECYYPERNEWRMITAMNTIRS 508

Query: 500 LHAMVGAGGRIYALGGRMDHVDRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLER 559
              +      IYA GG     D    + +VE Y  ET+ WT V+PM+  +S  G  + + 
Sbjct: 509 GAGVCVLHNCIYAAGG----YDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQG 564

Query: 560 KIYIVGGYNWRLNNVTGIVQVYNTDTDEWERDLHFPESFAGIACAPVLLP 609
           +IY++GGY+   +     V+ Y+ DTD W          +G+  A  + P
Sbjct: 565 RIYVLGGYDG--HTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEP 612


>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
          Length = 624

 Score =  217 bits (553), Expect = 2e-56
 Identities = 159/590 (26%), Positives = 263/590 (44%), Gaps = 29/590 (4%)

Query: 29  TADKNGALKCTFSAPSHSTSLLQGLATLRAQGQLLDVVLTINREAFPA-----HKVVLAA 83
           T  ++G    +++   H+      +  LR   QL DV L +  +  PA     HKVVLA+
Sbjct: 43  TPSQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLAS 102

Query: 84  CSDYFRAMFTGGMREASQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFL 143
            S  F+AMFT G+RE   +V+ ++G+  + +  +I+FAY+A +++   CV  V+  AV  
Sbjct: 103 SSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMY 162

Query: 144 QMLPVVELCEEFLKAAMSVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLR 203
           Q+  VV  C +FL   +     + I   A       L +    + + HF ++A++E+F  
Sbjct: 163 QIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFN 222

Query: 204 LPLERLVFFLQSNRLQSCAEIDLFRAAVRWLQHD-PARRPRASHVLCHIRFPLMQSSELV 262
           L   +LV  +  + L    E ++F A + W+++D   RR     +L  +R   +  + L 
Sbjct: 223 LSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQ 282

Query: 263 DSVQTLDIMVEDVLCRQYLLEAFNYQVLPFRQHEMQSPRTAVRSDVPSLVTFGGTPYTDS 322
             +Q  +I+  D  C+ YL++        F +  +  P   +    P +   G   YT  
Sbjct: 283 MQLQKCEILQSDSRCKDYLVKI-------FEELTLHKPTQVMPCRAPKV---GRLIYTAG 332

Query: 323 DRSVSSKVY-QLPEPGARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVD 381
                S  Y +   P    +  L +++V  S     V+   +Y  GG++    S +G  D
Sbjct: 333 GYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRN---NSPDGNTD 389

Query: 382 --ACYRYDPHLNRWLRLQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNE 439
             A   Y+P  N+W     M   R +  + V+ G +YA GG +      SVERY P R+E
Sbjct: 390 SSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDE 449

Query: 440 WGYACSLKRRTWGHAGAASGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRV 499
           W     +  R  G   A     LY  GG+        +  CY P  ++W     M+  R 
Sbjct: 450 WHLVAPMLTRRIGVGVAVLNRLLYAVGGFD-GTNRLNSAECYYPERNEWRMITAMNTIRS 508

Query: 500 LHAMVGAGGRIYALGGRMDHVDRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLER 559
              +      IYA GG     D    + +VE Y  ET+ WT V+PM+  +S  G  + + 
Sbjct: 509 GAGVCVLHNCIYAAGG----YDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQG 564

Query: 560 KIYIVGGYNWRLNNVTGIVQVYNTDTDEWERDLHFPESFAGIACAPVLLP 609
           +IY++GGY+   +     V+ Y+ DTD W          +G+  A  + P
Sbjct: 565 RIYVLGGYDG--HTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEP 612


>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
           [Homo sapiens]
          Length = 584

 Score =  209 bits (531), Expect = 8e-54
 Identities = 158/566 (27%), Positives = 258/566 (45%), Gaps = 30/566 (5%)

Query: 40  FSAPSHSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREA 99
           FS+  H+  +L  +  +R      DV L + +E+F AH++VLAA S YF A+FTGGM+E+
Sbjct: 14  FSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKES 73

Query: 100 SQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAA 159
           S+DV+ + G+ A   + ++DF Y+  V + ++ VQ+++ AA  LQ+  VV LC EFLK  
Sbjct: 74  SKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQ 133

Query: 160 MSVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQ 219
           +    C+ I Q +   +   L E  + +   HFL++   E+FL L  ++L+  L+S  L 
Sbjct: 134 IDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELS 193

Query: 220 SCAEIDLFRAAVRWLQHD-PARRPRASHVLCHIRFPLMQSSEL---VDSVQTLDIMVE-D 274
              E  +F AA++W+  D   RR     VL  IRFPL+    L   ++ V   ++ V   
Sbjct: 194 IEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQ 253

Query: 275 VLCRQY---LLEAFNYQVLPFRQHEMQSPRTAVRSDVPSLVTFGGTPYTDSDRSVSSKVY 331
            L ++Y          +   F Q     PR   R     L   GG       R   S+  
Sbjct: 254 TLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARK---YLYAVGGYTRLQGGRWSDSRAL 310

Query: 332 QLPE---PGARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDP 388
              E     ++++  ++ +    S   V VL   VY  GG+           D    YDP
Sbjct: 311 SCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGE-----KDSMIFDCTECYDP 365

Query: 389 HLNRWLRLQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKR 448
              +W  + +M   R    + V  G +YA GG   A    ++ER+ P  N+W    ++  
Sbjct: 366 VTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAV 425

Query: 449 RTWGHAGAASGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGG 508
             +        G +Y+ GG      + ++   YDP++ +W    PM   R    +     
Sbjct: 426 SRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALND 485

Query: 509 RIYALGGRMDHVDRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAGCCL--LERKIYIVGG 566
            IY++GG  +  D    +  VE Y  E ++W  V+ M+     AG C+  +   +Y+ GG
Sbjct: 486 CIYSVGGWNETQDA---LHTVEKYSFEEEKWVEVASMKV--PRAGMCVVAVNGLLYVSGG 540

Query: 567 ----YNWRLNNVTGIVQVYNTDTDEW 588
               +++        V+VYN  +D W
Sbjct: 541 RSSSHDFLAPGTLDSVEVYNPHSDTW 566



 Score = 36.2 bits (82), Expect = 0.091
 Identities = 20/70 (28%), Positives = 36/70 (51%), Gaps = 1/70 (1%)

Query: 343 ELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRS-GEGAVDACYRYDPHLNRWLRLQAMQE 401
           E+  M+V  +  CV  ++  +YV+GG+   +     G +D+   Y+PH + W  +  M  
Sbjct: 515 EVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMIT 574

Query: 402 SRIQFQLNVL 411
           SR +  + VL
Sbjct: 575 SRCEGGVAVL 584


>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
          Length = 586

 Score =  208 bits (529), Expect = 1e-53
 Identities = 155/544 (28%), Positives = 249/544 (45%), Gaps = 36/544 (6%)

Query: 56  LRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREASQDVIELKGVSARGLR 115
           +R Q  L DV+L +     PAH+VVLAA S +F  MFT  M E+    +ELK      + 
Sbjct: 37  MRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIE 96

Query: 116 HIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMSVETCLNIGQMATTF 175
            +++FAY+A ++++ + VQ +L AA   Q+ PV ++C +FLK  +    CL I  +A   
Sbjct: 97  QLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECL 156

Query: 176 SLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQSCAEIDLFRAAVRWLQ 235
               L+ + D F  +HF ++ + ++FL+L ++R+   L  + L   AE  ++ AAVRWL+
Sbjct: 157 DCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLK 216

Query: 236 HD-PARRPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLCRQYLLEAFNYQVL--PF 292
           +D P R+P    +L  +RFPL+  + L  +VQ   ++ ++  C + ++    Y +L    
Sbjct: 217 YDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPED 276

Query: 293 RQHEMQSPRTAVRSDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPGARHFRELTEMEVGCS 352
           R+  +   R   +     +  FGG+    S R  + K Y   +            E    
Sbjct: 277 REELVDGTRPRRKKHDYRIALFGGS-QPQSCRYFNPKDYSWTDIRC-------PFEKRRD 328

Query: 353 HTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQAMQESRIQFQLNVLC 412
             CV   DN VY+ GG  L        +     Y+   + W         R         
Sbjct: 329 AACV-FWDNVVYILGGSQL------FPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAE 381

Query: 413 GMVYATGGRNRAGS-LASVERYCPRRNEWGYACSLKRRTWGHAGAASGGRLYISGG-YGI 470
           G +Y +GG     S L   E Y  R   W    S+  +   H    + G +Y+ GG  G 
Sbjct: 382 GKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGN 441

Query: 471 SVEDKKALHC--YDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGR--MDHVDRCFDV 526
           +V  +    C  YDP  + W    PM E R  H +V    +I+A+GG+  +  +D     
Sbjct: 442 NVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDN---- 497

Query: 527 LAVEYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYN--WRLNNVTGIVQVYNTD 584
             VEYY  + ++W  VSPM        C  +   +Y++ G+    RL    G +  YNT+
Sbjct: 498 --VEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRL----GHILEYNTE 551

Query: 585 TDEW 588
           TD+W
Sbjct: 552 TDKW 555


>gi|55925608 kelch-like 21 [Homo sapiens]
          Length = 597

 Score =  208 bits (529), Expect = 1e-53
 Identities = 168/565 (29%), Positives = 260/565 (46%), Gaps = 36/565 (6%)

Query: 40  FSAPSHSTSLLQGLATLRAQGQLLDVVL-TINREAFPAHKVVLAACSDYFRAMFTGGMRE 98
           FS P+H+ SLL+GL+ LRA+ + LDV L       FPAH+ VLAA S YFRAMF G +RE
Sbjct: 12  FSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRE 71

Query: 99  ASQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKA 158
           +  + + L GV    L+ ++DF+Y+  V +  D  + +L AA  LQ   V E C  FL+ 
Sbjct: 72  SRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQ 131

Query: 159 AMSVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRL 218
            + +  CL++   A  FS + L  +   F  RH  ++  E+   RLPL RL+ +L+ + L
Sbjct: 132 QLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAEQ-LERLPLARLLRYLRDDGL 190

Query: 219 QSCAEIDLFRAAVRWLQHDPARRPRASH---VLCHIRFPLMQSSELVDSVQTLDIMVEDV 275
               E   ++ A+RW++ DP R  RA+H   +L  +R P ++   L+  V+   ++    
Sbjct: 191 CVPKEEAAYQLALRWVRADPPR--RAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCP 248

Query: 276 LCRQYLLEAFNYQVLPFRQHEM-QSPRTAVRSD---VPSLVTFGGTPYTDSDRSVSSKVY 331
            C + L EA ++Q   + +H+    PR   R        LV  GG    D D  V+   Y
Sbjct: 249 PCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCD-QDCDELVTVDCY 307

Query: 332 QLPEPGARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLN 391
             P+ G   +       +G  ++ VA L N +YV GG       G    D  +RY+  +N
Sbjct: 308 N-PQTGQWRYLAEFPDHLGGGYSIVA-LGNDIYVTGGS-----DGSRLYDCVWRYNSSVN 360

Query: 392 RWLRLQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTW 451
            W  +  M ++R     +VL G++Y         +  S ERY    + W     +     
Sbjct: 361 EWAEVAPMLKAREYHSSSVLDGLLYVV-------AADSTERYDHTTDSWEALQPMTYPMD 413

Query: 452 GHAGAASGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIY 511
             +  A  GRLY  G   ++ ++   + CYDP  D W        P    A   A     
Sbjct: 414 NCSTTACRGRLYAIG--SLAGKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTA----- 466

Query: 512 ALGGRMDHVDRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNWRL 571
            L G M  V    D   V+ Y P  ++W  +  M          +L  K+Y+ GGY+   
Sbjct: 467 TLNGLMYFVRD--DSAEVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYD-NT 523

Query: 572 NNVTGIVQVYNTDTDEWERDLHFPE 596
             ++ +V+ Y+ +T  W      PE
Sbjct: 524 FELSDVVEAYDPETRAWSVVGRLPE 548


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.137    0.422 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,356,005
Number of Sequences: 37866
Number of extensions: 1111905
Number of successful extensions: 8769
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 248
Number of HSP's successfully gapped in prelim test: 57
Number of HSP's that attempted gapping in prelim test: 6052
Number of HSP's gapped (non-prelim): 1422
length of query: 615
length of database: 18,247,518
effective HSP length: 108
effective length of query: 507
effective length of database: 14,157,990
effective search space: 7178100930
effective search space used: 7178100930
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.