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Search of human proteins with 88758596
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo
sapiens]
(1124 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sap... 2321 0.0
gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like... 955 0.0
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 249 8e-66
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur... 249 8e-66
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 249 8e-66
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu... 247 5e-65
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu... 244 3e-64
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 244 3e-64
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu... 244 3e-64
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu... 244 3e-64
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu... 244 3e-64
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu... 244 3e-64
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu... 244 3e-64
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 244 3e-64
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 244 4e-64
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 244 4e-64
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 244 4e-64
gi|10862701 ret proto-oncogene isoform c [Homo sapiens] 244 4e-64
gi|10862703 ret proto-oncogene isoform a [Homo sapiens] 244 4e-64
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu... 244 4e-64
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 241 3e-63
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 241 3e-63
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 241 3e-63
gi|4758280 ephrin receptor EphA4 [Homo sapiens] 217 4e-56
gi|221625422 ephrin receptor EphA5 isoform b precursor [Homo sap... 215 2e-55
gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens] 215 2e-55
gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens] 213 6e-55
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 211 4e-54
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 211 4e-54
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 211 4e-54
>gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sapiens]
Length = 1124
Score = 2321 bits (6014), Expect = 0.0
Identities = 1124/1124 (100%), Positives = 1124/1124 (100%)
Query: 1 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRD 60
MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRD
Sbjct: 1 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRD 60
Query: 61 FEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQ 120
FEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQ
Sbjct: 61 FEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQ 120
Query: 121 QASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPH 180
QASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPH
Sbjct: 121 QASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPH 180
Query: 181 AQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGEC 240
AQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGEC
Sbjct: 181 AQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGEC 240
Query: 241 ICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNE 300
ICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNE
Sbjct: 241 ICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNE 300
Query: 301 ACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIPRMTPKIVDLPDHIE 360
ACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIPRMTPKIVDLPDHIE
Sbjct: 301 ACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIPRMTPKIVDLPDHIE 360
Query: 361 VNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSG 420
VNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSG
Sbjct: 361 VNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSG 420
Query: 421 VWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKK 480
VWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKK
Sbjct: 421 VWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKK 480
Query: 481 LLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTAS 540
LLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTAS
Sbjct: 481 LLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTAS 540
Query: 541 IGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSV 600
IGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSV
Sbjct: 541 IGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSV 600
Query: 601 LLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWT 660
LLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWT
Sbjct: 601 LLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWT 660
Query: 661 ILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGS 720
ILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGS
Sbjct: 661 ILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGS 720
Query: 721 SNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRR 780
SNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRR
Sbjct: 721 SNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRR 780
Query: 781 MAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLK 840
MAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLK
Sbjct: 781 MAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLK 840
Query: 841 ARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYL 900
ARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYL
Sbjct: 841 ARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYL 900
Query: 901 AIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQF 960
AIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQF
Sbjct: 901 AIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQF 960
Query: 961 IHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSD 1020
IHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSD
Sbjct: 961 IHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSD 1020
Query: 1021 VWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPY 1080
VWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPY
Sbjct: 1021 VWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPY 1080
Query: 1081 ERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA 1124
ERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
Sbjct: 1081 ERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA 1124
>gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like
domains 1 [Homo sapiens]
Length = 1138
Score = 955 bits (2469), Expect = 0.0
Identities = 530/1141 (46%), Positives = 695/1141 (60%), Gaps = 46/1141 (4%)
Query: 14 LLLSGTVEGAMDLILINSLPLVSDAETSLTCIAS---------GWRPHEPITIGRDFEAL 64
L L+ V A+DL L+ +L L LTC++ W P P+ + +D +
Sbjct: 13 LFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGP--PLLLEKDDRIV 70
Query: 65 MNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQQASF 124
PL + ++ + + + K S + G + C G R+ + A
Sbjct: 71 RTPPGPPLRLARNGSHQVTLRGF---SKPSDLVGVFSCVGGAGARRTRVIYVHNSPGAHL 127
Query: 125 LPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPD-ILEVHLPHAQP 183
LP +T TV+KGD +S + K+ D + NGS+ +++ HE D + LP+ QP
Sbjct: 128 LPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLLQLPNVQP 187
Query: 184 QDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGECICP 243
+G+YSA Y+ + SAF RLIVR C A +WGP C C C++ GVCH+ GEC+CP
Sbjct: 188 PSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLHGGVCHDHDGECVCP 247
Query: 244 PGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNEACH 303
PGF G CE+AC FG++C+E+C G GC+ FCLPDPYGCSC +GW+G QC EAC
Sbjct: 248 PGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSCGSGWRGSQCQEACA 307
Query: 304 PGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIPRMTPKIVDLPDHIEVNS 363
PG +G DC+L+C C NG CDRF GC+C GW G+ CE+ P+I+++ +E N
Sbjct: 308 PGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSD---RIPQILNMASELEFNL 364
Query: 364 GKFNPI-CKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSGVW 422
I C A+G P P + L KPDGTVL + A F + R++ DSG W
Sbjct: 365 ETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLADSGFW 424
Query: 423 VCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKKLL 482
C V+T G + F ++VKV P PL AP ++ V++ + GDGPI + +L
Sbjct: 425 ECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLLTKQSRQLVVS-PLVSFSGDGPISTVRLH 483
Query: 483 YKPVNHYEAWQHIQVT-NEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTASI 541
Y+P + W I V +E VTL L P+T Y + VQL R GEGGEG GP TT
Sbjct: 484 YRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTT--- 540
Query: 542 GLPPPRGLNLLP----KSQTTLNLTWQ-PIFPSS--EDDFYVEVERRSVQKSDQQNIKVP 594
P P L + L ++W P+ P D F + + + + ++N+ P
Sbjct: 541 DCPEPLLQPWLEGWHVEGTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSP 600
Query: 595 GNLTSVLLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSS 654
T+ LL L P Y + ++ + L PP P ++ ++ S
Sbjct: 601 QARTA-LLTGLTPGTHYQLDVQLYHCTLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSE 659
Query: 655 AVISWTILDGYS--ISSITIRYKVQGKNEDQ-HVDVKIKNATITQYQLKGLEPETAYQVD 711
++W + IS + +V G D +DV T T ++GL T Y
Sbjct: 660 IQLTWKHPEALPGPISKYVVEVQVAGGAGDPLWIDVDRPEETSTI--IRGLNASTRYLFR 717
Query: 712 IFAE-NNIGS-SNPAFSHELVTLPESQAP------ADLGGGKMLLIAILGSAGMTCLTVL 763
+ A +G SN L +++ P A+ G + L++A++GS TCLT+L
Sbjct: 718 MRASIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTIL 777
Query: 764 LAFLIILQLKRANVQRRMAQAFQNVR-EEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWN 822
A L ++ ++R+ + RR +Q+ EE +QF+SGTL L R+ K P+P YPVL+W
Sbjct: 778 AALLTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWE 837
Query: 823 DIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHH 882
DI F+D+IGEGNFGQV++A IKKDGL+M+AAIK +KEYAS++DHRDFAGELEVLCKLGHH
Sbjct: 838 DITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHH 897
Query: 883 PNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLL 942
PNIINLLGAC++RGYLY+AIEYAP+GNLLDFLRKSRVLETDPAFA + TASTLSS+QLL
Sbjct: 898 PNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLL 957
Query: 943 HFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPV 1002
FA+D A GM YLS+KQFIHRDLAARN+LVGEN +KIADFGLSRG+EVYVKKTMGRLPV
Sbjct: 958 RFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPV 1017
Query: 1003 RWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLN 1062
RWMAIESLNYSVYTT SDVWS+GVLLWEIVSLGGTPYCGMTCAELYEKLPQGYR+E+P N
Sbjct: 1018 RWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRN 1077
Query: 1063 CDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEE 1122
CDDEVY+LMRQCWR++PYERP FAQI + L RMLE RK YVN +L+E FTYAGID +AEE
Sbjct: 1078 CDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEE 1137
Query: 1123 A 1123
A
Sbjct: 1138 A 1138
>gi|254028242 fibroblast growth factor receptor 3 isoform 3 precursor
[Homo sapiens]
Length = 808
Score = 249 bits (637), Expect = 8e-66
Identities = 137/306 (44%), Positives = 195/306 (63%), Gaps = 11/306 (3%)
Query: 830 IGEGNFGQVLKAR---IKKDGLR--MDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884
+GEG FGQV+ A I KD + A+K +K+ A+ D D E+E++ +G H N
Sbjct: 480 LGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKN 539
Query: 885 IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944
IINLLGAC G LY+ +EYA GNL +FLR R D +F L+ + L+
Sbjct: 540 IINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSC 599
Query: 945 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR---GQEVYVKKTMGRLP 1001
A VARGM+YL+ ++ IHRDLAARN+LV E+ V KIADFGL+R + Y K T GRLP
Sbjct: 600 AYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLP 659
Query: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061
V+WMA E+L VYT SDVWS+GVLLWEI +LGG+PY G+ EL++ L +G+R++KP
Sbjct: 660 VKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA 719
Query: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKT--YVNTTL-YEKFTYAGIDC 1118
NC ++Y +MR+CW P +RP+F Q++ L+R+L T Y++ + +E+++ G D
Sbjct: 720 NCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDT 779
Query: 1119 SAEEAA 1124
+ ++
Sbjct: 780 PSSSSS 785
>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
[Homo sapiens]
Length = 694
Score = 249 bits (637), Expect = 8e-66
Identities = 137/306 (44%), Positives = 195/306 (63%), Gaps = 11/306 (3%)
Query: 830 IGEGNFGQVLKAR---IKKDGLR--MDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884
+GEG FGQV+ A I KD + A+K +K+ A+ D D E+E++ +G H N
Sbjct: 366 LGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKN 425
Query: 885 IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944
IINLLGAC G LY+ +EYA GNL +FLR R D +F L+ + L+
Sbjct: 426 IINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSC 485
Query: 945 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR---GQEVYVKKTMGRLP 1001
A VARGM+YL+ ++ IHRDLAARN+LV E+ V KIADFGL+R + Y K T GRLP
Sbjct: 486 AYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLP 545
Query: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061
V+WMA E+L VYT SDVWS+GVLLWEI +LGG+PY G+ EL++ L +G+R++KP
Sbjct: 546 VKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA 605
Query: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKT--YVNTTL-YEKFTYAGIDC 1118
NC ++Y +MR+CW P +RP+F Q++ L+R+L T Y++ + +E+++ G D
Sbjct: 606 NCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDT 665
Query: 1119 SAEEAA 1124
+ ++
Sbjct: 666 PSSSSS 671
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 249 bits (637), Expect = 8e-66
Identities = 137/306 (44%), Positives = 195/306 (63%), Gaps = 11/306 (3%)
Query: 830 IGEGNFGQVLKAR---IKKDGLR--MDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884
+GEG FGQV+ A I KD + A+K +K+ A+ D D E+E++ +G H N
Sbjct: 478 LGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKN 537
Query: 885 IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944
IINLLGAC G LY+ +EYA GNL +FLR R D +F L+ + L+
Sbjct: 538 IINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSC 597
Query: 945 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR---GQEVYVKKTMGRLP 1001
A VARGM+YL+ ++ IHRDLAARN+LV E+ V KIADFGL+R + Y K T GRLP
Sbjct: 598 AYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLP 657
Query: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061
V+WMA E+L VYT SDVWS+GVLLWEI +LGG+PY G+ EL++ L +G+R++KP
Sbjct: 658 VKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA 717
Query: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKT--YVNTTL-YEKFTYAGIDC 1118
NC ++Y +MR+CW P +RP+F Q++ L+R+L T Y++ + +E+++ G D
Sbjct: 718 NCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDT 777
Query: 1119 SAEEAA 1124
+ ++
Sbjct: 778 PSSSSS 783
>gi|222144235 fibroblast growth factor receptor 2 isoform 5 precursor
[Homo sapiens]
Length = 707
Score = 247 bits (630), Expect = 5e-65
Identities = 133/297 (44%), Positives = 189/297 (63%), Gaps = 13/297 (4%)
Query: 830 IGEGNFGQVLKAR---IKKDGLR--MDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884
+GEG FGQV+ A I KD + + A+K +K+ A++ D D E+E++ +G H N
Sbjct: 398 LGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKN 457
Query: 885 IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944
IINLLGAC G LY+ +EYA GNL ++LR R + ++ I ++ + L+
Sbjct: 458 IINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSC 517
Query: 945 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR---GQEVYVKKTMGRLP 1001
+ARGM+YL+ ++ IHRDLAARN+LV EN V KIADFGL+R + Y K T GRLP
Sbjct: 518 TYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLP 577
Query: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061
V+WMA E+L VYT SDVWS+GVL+WEI +LGG+PY G+ EL++ L +G+R++KP
Sbjct: 578 VKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA 637
Query: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDC 1118
NC +E+Y +MR CW P +RP+F Q++ L+R+L + T EK +DC
Sbjct: 638 NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILT-----LTTNEEEKKVSGAVDC 689
>gi|222144244 fibroblast growth factor receptor 2 isoform 9 precursor
[Homo sapiens]
Length = 680
Score = 244 bits (623), Expect = 3e-64
Identities = 128/275 (46%), Positives = 182/275 (66%), Gaps = 8/275 (2%)
Query: 830 IGEGNFGQVLKAR---IKKDGLR--MDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884
+GEG FGQV+ A I KD + + A+K +K+ A++ D D E+E++ +G H N
Sbjct: 399 LGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKN 458
Query: 885 IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944
IINLLGAC G LY+ +EYA GNL ++LR R + ++ I ++ + L+
Sbjct: 459 IINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSC 518
Query: 945 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR---GQEVYVKKTMGRLP 1001
+ARGM+YL+ ++ IHRDLAARN+LV EN V KIADFGL+R + Y K T GRLP
Sbjct: 519 TYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLP 578
Query: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061
V+WMA E+L VYT SDVWS+GVL+WEI +LGG+PY G+ EL++ L +G+R++KP
Sbjct: 579 VKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA 638
Query: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRML 1096
NC +E+Y +MR CW P +RP+F Q++ L+R+L
Sbjct: 639 NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 673
>gi|222144231 fibroblast growth factor receptor 2 isoform 3 precursor
[Homo sapiens]
Length = 769
Score = 244 bits (623), Expect = 3e-64
Identities = 128/275 (46%), Positives = 182/275 (66%), Gaps = 8/275 (2%)
Query: 830 IGEGNFGQVLKAR---IKKDGLR--MDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884
+GEG FGQV+ A I KD + + A+K +K+ A++ D D E+E++ +G H N
Sbjct: 488 LGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKN 547
Query: 885 IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944
IINLLGAC G LY+ +EYA GNL ++LR R + ++ I ++ + L+
Sbjct: 548 IINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSC 607
Query: 945 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR---GQEVYVKKTMGRLP 1001
+ARGM+YL+ ++ IHRDLAARN+LV EN V KIADFGL+R + Y K T GRLP
Sbjct: 608 TYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLP 667
Query: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061
V+WMA E+L VYT SDVWS+GVL+WEI +LGG+PY G+ EL++ L +G+R++KP
Sbjct: 668 VKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA 727
Query: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRML 1096
NC +E+Y +MR CW P +RP+F Q++ L+R+L
Sbjct: 728 NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 762
>gi|222144241 fibroblast growth factor receptor 2 isoform 8 precursor
[Homo sapiens]
Length = 704
Score = 244 bits (623), Expect = 3e-64
Identities = 128/275 (46%), Positives = 182/275 (66%), Gaps = 8/275 (2%)
Query: 830 IGEGNFGQVLKAR---IKKDGLR--MDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884
+GEG FGQV+ A I KD + + A+K +K+ A++ D D E+E++ +G H N
Sbjct: 370 LGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKN 429
Query: 885 IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944
IINLLGAC G LY+ +EYA GNL ++LR R + ++ I ++ + L+
Sbjct: 430 IINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSC 489
Query: 945 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR---GQEVYVKKTMGRLP 1001
+ARGM+YL+ ++ IHRDLAARN+LV EN V KIADFGL+R + Y K T GRLP
Sbjct: 490 TYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLP 549
Query: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061
V+WMA E+L VYT SDVWS+GVL+WEI +LGG+PY G+ EL++ L +G+R++KP
Sbjct: 550 VKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA 609
Query: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRML 1096
NC +E+Y +MR CW P +RP+F Q++ L+R+L
Sbjct: 610 NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 644
>gi|222144239 fibroblast growth factor receptor 2 isoform 7 precursor
[Homo sapiens]
Length = 705
Score = 244 bits (623), Expect = 3e-64
Identities = 128/275 (46%), Positives = 182/275 (66%), Gaps = 8/275 (2%)
Query: 830 IGEGNFGQVLKAR---IKKDGLR--MDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884
+GEG FGQV+ A I KD + + A+K +K+ A++ D D E+E++ +G H N
Sbjct: 371 LGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKN 430
Query: 885 IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944
IINLLGAC G LY+ +EYA GNL ++LR R + ++ I ++ + L+
Sbjct: 431 IINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSC 490
Query: 945 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR---GQEVYVKKTMGRLP 1001
+ARGM+YL+ ++ IHRDLAARN+LV EN V KIADFGL+R + Y K T GRLP
Sbjct: 491 TYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLP 550
Query: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061
V+WMA E+L VYT SDVWS+GVL+WEI +LGG+PY G+ EL++ L +G+R++KP
Sbjct: 551 VKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA 610
Query: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRML 1096
NC +E+Y +MR CW P +RP+F Q++ L+R+L
Sbjct: 611 NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 645
>gi|222144237 fibroblast growth factor receptor 2 isoform 6 precursor
[Homo sapiens]
Length = 706
Score = 244 bits (623), Expect = 3e-64
Identities = 128/275 (46%), Positives = 182/275 (66%), Gaps = 8/275 (2%)
Query: 830 IGEGNFGQVLKAR---IKKDGLR--MDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884
+GEG FGQV+ A I KD + + A+K +K+ A++ D D E+E++ +G H N
Sbjct: 372 LGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKN 431
Query: 885 IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944
IINLLGAC G LY+ +EYA GNL ++LR R + ++ I ++ + L+
Sbjct: 432 IINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSC 491
Query: 945 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR---GQEVYVKKTMGRLP 1001
+ARGM+YL+ ++ IHRDLAARN+LV EN V KIADFGL+R + Y K T GRLP
Sbjct: 492 TYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLP 551
Query: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061
V+WMA E+L VYT SDVWS+GVL+WEI +LGG+PY G+ EL++ L +G+R++KP
Sbjct: 552 VKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA 611
Query: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRML 1096
NC +E+Y +MR CW P +RP+F Q++ L+R+L
Sbjct: 612 NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 646
>gi|222144233 fibroblast growth factor receptor 2 isoform 4 precursor
[Homo sapiens]
Length = 709
Score = 244 bits (623), Expect = 3e-64
Identities = 128/275 (46%), Positives = 182/275 (66%), Gaps = 8/275 (2%)
Query: 830 IGEGNFGQVLKAR---IKKDGLR--MDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884
+GEG FGQV+ A I KD + + A+K +K+ A++ D D E+E++ +G H N
Sbjct: 375 LGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKN 434
Query: 885 IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944
IINLLGAC G LY+ +EYA GNL ++LR R + ++ I ++ + L+
Sbjct: 435 IINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSC 494
Query: 945 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR---GQEVYVKKTMGRLP 1001
+ARGM+YL+ ++ IHRDLAARN+LV EN V KIADFGL+R + Y K T GRLP
Sbjct: 495 TYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLP 554
Query: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061
V+WMA E+L VYT SDVWS+GVL+WEI +LGG+PY G+ EL++ L +G+R++KP
Sbjct: 555 VKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA 614
Query: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRML 1096
NC +E+Y +MR CW P +RP+F Q++ L+R+L
Sbjct: 615 NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 649
>gi|221316639 fibroblast growth factor receptor 2 isoform 1 precursor
[Homo sapiens]
Length = 821
Score = 244 bits (623), Expect = 3e-64
Identities = 128/275 (46%), Positives = 182/275 (66%), Gaps = 8/275 (2%)
Query: 830 IGEGNFGQVLKAR---IKKDGLR--MDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884
+GEG FGQV+ A I KD + + A+K +K+ A++ D D E+E++ +G H N
Sbjct: 487 LGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKN 546
Query: 885 IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944
IINLLGAC G LY+ +EYA GNL ++LR R + ++ I ++ + L+
Sbjct: 547 IINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSC 606
Query: 945 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR---GQEVYVKKTMGRLP 1001
+ARGM+YL+ ++ IHRDLAARN+LV EN V KIADFGL+R + Y K T GRLP
Sbjct: 607 TYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLP 666
Query: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061
V+WMA E+L VYT SDVWS+GVL+WEI +LGG+PY G+ EL++ L +G+R++KP
Sbjct: 667 VKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA 726
Query: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRML 1096
NC +E+Y +MR CW P +RP+F Q++ L+R+L
Sbjct: 727 NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 761
>gi|221316638 fibroblast growth factor receptor 2 isoform 2 precursor
[Homo sapiens]
Length = 822
Score = 244 bits (623), Expect = 3e-64
Identities = 128/275 (46%), Positives = 182/275 (66%), Gaps = 8/275 (2%)
Query: 830 IGEGNFGQVLKAR---IKKDGLR--MDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884
+GEG FGQV+ A I KD + + A+K +K+ A++ D D E+E++ +G H N
Sbjct: 488 LGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKN 547
Query: 885 IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944
IINLLGAC G LY+ +EYA GNL ++LR R + ++ I ++ + L+
Sbjct: 548 IINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSC 607
Query: 945 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR---GQEVYVKKTMGRLP 1001
+ARGM+YL+ ++ IHRDLAARN+LV EN V KIADFGL+R + Y K T GRLP
Sbjct: 608 TYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLP 667
Query: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061
V+WMA E+L VYT SDVWS+GVL+WEI +LGG+PY G+ EL++ L +G+R++KP
Sbjct: 668 VKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA 727
Query: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRML 1096
NC +E+Y +MR CW P +RP+F Q++ L+R+L
Sbjct: 728 NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 762
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 244 bits (622), Expect = 4e-64
Identities = 128/275 (46%), Positives = 180/275 (65%), Gaps = 8/275 (2%)
Query: 830 IGEGNFGQVLKARI-----KKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884
+GEG FGQV+ A K A+K +K A++ D D E+E++ +G H N
Sbjct: 393 LGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 452
Query: 885 IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944
IINLLGAC G LY+ +EYA GNL ++L+ R + + +++ LSS+ L+
Sbjct: 453 IINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSC 512
Query: 945 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ---EVYVKKTMGRLP 1001
A VARGM+YL+ K+ IHRDLAARN+LV E+ V KIADFGL+R + Y K T GRLP
Sbjct: 513 AYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLP 572
Query: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061
V+WMA E+L +YT SDVWS+GVLLWEI +LGG+PY G+ EL++ L +G+R++KP
Sbjct: 573 VKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPS 632
Query: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRML 1096
NC +E+Y +MR CW P +RP+F Q++ L+R++
Sbjct: 633 NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIV 667
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 244 bits (622), Expect = 4e-64
Identities = 128/275 (46%), Positives = 180/275 (65%), Gaps = 8/275 (2%)
Query: 830 IGEGNFGQVLKARI-----KKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884
+GEG FGQV+ A K A+K +K A++ D D E+E++ +G H N
Sbjct: 395 LGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 454
Query: 885 IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944
IINLLGAC G LY+ +EYA GNL ++L+ R + + +++ LSS+ L+
Sbjct: 455 IINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSC 514
Query: 945 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ---EVYVKKTMGRLP 1001
A VARGM+YL+ K+ IHRDLAARN+LV E+ V KIADFGL+R + Y K T GRLP
Sbjct: 515 AYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLP 574
Query: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061
V+WMA E+L +YT SDVWS+GVLLWEI +LGG+PY G+ EL++ L +G+R++KP
Sbjct: 575 VKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPS 634
Query: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRML 1096
NC +E+Y +MR CW P +RP+F Q++ L+R++
Sbjct: 635 NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIV 669
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 244 bits (622), Expect = 4e-64
Identities = 128/275 (46%), Positives = 180/275 (65%), Gaps = 8/275 (2%)
Query: 830 IGEGNFGQVLKARI-----KKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884
+GEG FGQV+ A K A+K +K A++ D D E+E++ +G H N
Sbjct: 482 LGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 541
Query: 885 IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944
IINLLGAC G LY+ +EYA GNL ++L+ R + + +++ LSS+ L+
Sbjct: 542 IINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSC 601
Query: 945 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ---EVYVKKTMGRLP 1001
A VARGM+YL+ K+ IHRDLAARN+LV E+ V KIADFGL+R + Y K T GRLP
Sbjct: 602 AYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLP 661
Query: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061
V+WMA E+L +YT SDVWS+GVLLWEI +LGG+PY G+ EL++ L +G+R++KP
Sbjct: 662 VKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPS 721
Query: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRML 1096
NC +E+Y +MR CW P +RP+F Q++ L+R++
Sbjct: 722 NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIV 756
>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
Length = 1072
Score = 244 bits (622), Expect = 4e-64
Identities = 131/291 (45%), Positives = 187/291 (64%), Gaps = 19/291 (6%)
Query: 830 IGEGNFGQVLKA---RIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNII 886
+GEG FG+V+KA +K A+K +KE AS + RD E VL K +HP++I
Sbjct: 730 LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVL-KQVNHPHVI 788
Query: 887 NLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTAST----------L 936
L GAC G L L +EYA +G+L FLR+SR + P + + + ++ L
Sbjct: 789 KLYGACSQDGPLLLIVEYAKYGSLRGFLRESR--KVGPGYLGSGGSRNSSSLDHPDERAL 846
Query: 937 SSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRG---QEVYV 993
+ L+ FA +++GM YL++ + +HRDLAARNILV E KI+DFGLSR ++ YV
Sbjct: 847 TMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYV 906
Query: 994 KKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQ 1053
K++ GR+PV+WMAIESL +YTT SDVWS+GVLLWEIV+LGG PY G+ L+ L
Sbjct: 907 KRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKT 966
Query: 1054 GYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVN 1104
G+R+E+P NC +E+Y LM QCW+++P +RP FA I L +M+ +R+ Y++
Sbjct: 967 GHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLD 1017
>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
Length = 1114
Score = 244 bits (622), Expect = 4e-64
Identities = 131/291 (45%), Positives = 187/291 (64%), Gaps = 19/291 (6%)
Query: 830 IGEGNFGQVLKA---RIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNII 886
+GEG FG+V+KA +K A+K +KE AS + RD E VL K +HP++I
Sbjct: 730 LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVL-KQVNHPHVI 788
Query: 887 NLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTAST----------L 936
L GAC G L L +EYA +G+L FLR+SR + P + + + ++ L
Sbjct: 789 KLYGACSQDGPLLLIVEYAKYGSLRGFLRESR--KVGPGYLGSGGSRNSSSLDHPDERAL 846
Query: 937 SSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRG---QEVYV 993
+ L+ FA +++GM YL++ + +HRDLAARNILV E KI+DFGLSR ++ YV
Sbjct: 847 TMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYV 906
Query: 994 KKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQ 1053
K++ GR+PV+WMAIESL +YTT SDVWS+GVLLWEIV+LGG PY G+ L+ L
Sbjct: 907 KRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKT 966
Query: 1054 GYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVN 1104
G+R+E+P NC +E+Y LM QCW+++P +RP FA I L +M+ +R+ Y++
Sbjct: 967 GHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLD 1017
>gi|105990522 fibroblast growth factor receptor 1 isoform 1 precursor
[Homo sapiens]
Length = 822
Score = 244 bits (622), Expect = 4e-64
Identities = 128/275 (46%), Positives = 180/275 (65%), Gaps = 8/275 (2%)
Query: 830 IGEGNFGQVLKARI-----KKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884
+GEG FGQV+ A K A+K +K A++ D D E+E++ +G H N
Sbjct: 484 LGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 543
Query: 885 IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944
IINLLGAC G LY+ +EYA GNL ++L+ R + + +++ LSS+ L+
Sbjct: 544 IINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSC 603
Query: 945 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ---EVYVKKTMGRLP 1001
A VARGM+YL+ K+ IHRDLAARN+LV E+ V KIADFGL+R + Y K T GRLP
Sbjct: 604 AYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLP 663
Query: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061
V+WMA E+L +YT SDVWS+GVLLWEI +LGG+PY G+ EL++ L +G+R++KP
Sbjct: 664 VKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPS 723
Query: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRML 1096
NC +E+Y +MR CW P +RP+F Q++ L+R++
Sbjct: 724 NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIV 758
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 241 bits (615), Expect = 3e-63
Identities = 131/275 (47%), Positives = 177/275 (64%), Gaps = 8/275 (2%)
Query: 830 IGEGNFGQVLKAR-IKKDGLRMD----AAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884
+GEG FGQV++A D R D A+K +K+ AS D D E+EV+ +G H N
Sbjct: 433 LGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKN 492
Query: 885 IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944
IINLLG C G LY+ +E A GNL +FLR R D + S+ LS L+
Sbjct: 493 IINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSC 552
Query: 945 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ---EVYVKKTMGRLP 1001
A VARGM YL ++ IHRDLAARN+LV E+ V KIADFGL+RG + Y K + GRLP
Sbjct: 553 AYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLP 612
Query: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061
V+WMA E+L VYT SDVWS+G+LLWEI +LGG+PY G+ EL+ L +G+R+++P
Sbjct: 613 VKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPP 672
Query: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRML 1096
+C E+Y LMR+CW P +RP+F Q++ +L+++L
Sbjct: 673 HCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL 707
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 241 bits (615), Expect = 3e-63
Identities = 131/275 (47%), Positives = 177/275 (64%), Gaps = 8/275 (2%)
Query: 830 IGEGNFGQVLKAR-IKKDGLRMD----AAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884
+GEG FGQV++A D R D A+K +K+ AS D D E+EV+ +G H N
Sbjct: 473 LGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKN 532
Query: 885 IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944
IINLLG C G LY+ +E A GNL +FLR R D + S+ LS L+
Sbjct: 533 IINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSC 592
Query: 945 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ---EVYVKKTMGRLP 1001
A VARGM YL ++ IHRDLAARN+LV E+ V KIADFGL+RG + Y K + GRLP
Sbjct: 593 AYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLP 652
Query: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061
V+WMA E+L VYT SDVWS+G+LLWEI +LGG+PY G+ EL+ L +G+R+++P
Sbjct: 653 VKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPP 712
Query: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRML 1096
+C E+Y LMR+CW P +RP+F Q++ +L+++L
Sbjct: 713 HCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL 747
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 241 bits (615), Expect = 3e-63
Identities = 131/275 (47%), Positives = 177/275 (64%), Gaps = 8/275 (2%)
Query: 830 IGEGNFGQVLKAR-IKKDGLRMD----AAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884
+GEG FGQV++A D R D A+K +K+ AS D D E+EV+ +G H N
Sbjct: 473 LGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKN 532
Query: 885 IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944
IINLLG C G LY+ +E A GNL +FLR R D + S+ LS L+
Sbjct: 533 IINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSC 592
Query: 945 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ---EVYVKKTMGRLP 1001
A VARGM YL ++ IHRDLAARN+LV E+ V KIADFGL+RG + Y K + GRLP
Sbjct: 593 AYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLP 652
Query: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061
V+WMA E+L VYT SDVWS+G+LLWEI +LGG+PY G+ EL+ L +G+R+++P
Sbjct: 653 VKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPP 712
Query: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRML 1096
+C E+Y LMR+CW P +RP+F Q++ +L+++L
Sbjct: 713 HCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL 747
>gi|4758280 ephrin receptor EphA4 [Homo sapiens]
Length = 986
Score = 217 bits (553), Expect = 4e-56
Identities = 164/598 (27%), Positives = 271/598 (45%), Gaps = 70/598 (11%)
Query: 544 PPPRGLNLLPK-SQTTLNLTWQ-PIFPSSEDDFYVEVERRSVQKSDQQNIKVPGN----- 596
PP LNL+ ++T++NL W P D V + D + G+
Sbjct: 328 PPSAPLNLISNVNETSVNLEWSSPQNTGGRQDISYNVVCKKCGAGDPSKCRPCGSGVHYT 387
Query: 597 ------------LTSVLLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPEN 644
+T +L + + E + V + S +T T + P
Sbjct: 388 PQQNGLKTTKVSITDLLAHTNYTFEIWAVNGVSKYNPNPDQSVSVTV-TTNQAAPSSIAL 446
Query: 645 IKISNITHSSAVISWTILDGYSISSITIRYKVQGKNEDQHV-DVKIKNATITQYQLKGLE 703
++ +T S ++W L+ + + + Y+V+ +DQ+ +I +KGL
Sbjct: 447 VQAKEVTRYSVALAW--LEPDRPNGVILEYEVKYYEKDQNERSYRIVRTAARNTDIKGLN 504
Query: 704 PETAYQVDIFAENNIGSSNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVL 763
P T+Y + A G + FS L + +G G + ++ +G L V+
Sbjct: 505 PLTSYVFHVRARTAAGYGD--FSEPLEVTTNTVPSRIIGDGANSTVLLVSVSGSVVLVVI 562
Query: 764 LAFLIILQLKRANVQRRMAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYP------ 817
L ++ +R+ + ++A Q EE LN+ V+ DP Y
Sbjct: 563 LIAAFVISRRRS----KYSKAKQEADEEKH---------LNQGVRTYVDPFTYEDPNQAV 609
Query: 818 -----VLDWNDIKFQDVIGEGNFGQVLKARIKKDGLR-MDAAIKRMKEYASKDDHRDFAG 871
+D + IK + VIG G FG+V R+K G R + AIK +K + RDF
Sbjct: 610 REFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLS 669
Query: 872 ELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANS 931
E ++ + H PNII+L G + + EY +G+L FLRK+ D F +
Sbjct: 670 EASIMGQFDH-PNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKN-----DGRFTVI-- 721
Query: 932 TASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR---- 987
QL+ + GM YLS ++HRDLAARNILV N V K++DFG+SR
Sbjct: 722 --------QLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLED 773
Query: 988 GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAEL 1047
E G++P+RW A E++ Y +T+ SDVWSYG+++WE++S G PY M+ ++
Sbjct: 774 DPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDV 833
Query: 1048 YEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNT 1105
+ + +GYRL P++C ++ LM CW+++ +RP F QI+ L++++ + T
Sbjct: 834 IKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRNPNSLKRT 891
>gi|221625422 ephrin receptor EphA5 isoform b precursor [Homo sapiens]
Length = 1015
Score = 215 bits (548), Expect = 2e-55
Identities = 150/493 (30%), Positives = 242/493 (49%), Gaps = 47/493 (9%)
Query: 633 TLSDILPPQPENIKISNITHSSAVISWTILDGYSISSITIRYKVQGKNEDQHVDVKIKNA 692
T + P N+K I +S +SW D + I + Y+++ +DQ I +
Sbjct: 463 TTNQAAPSPVTNVKKGKIAKNSISLSWQEPD--RPNGIILEYEIKYFEKDQETSYTIIKS 520
Query: 693 TITQYQLKGLEPETAYQVDIFAENNIGSSNPAFSHELVTLPESQAPADLGGGKMLLIAIL 752
T +GL+P + Y I A G + E T P A +D ++ +IA+
Sbjct: 521 KETTITAEGLKPASVYVFQIRARTAAGYGVFSRRFEFETTPVFAASSDQS--QIPVIAVS 578
Query: 753 GSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNVREEPAVQFNSGTLALNRKVKNNPD 812
+ G+ L V++ ++L +R + EE + F++G + L V+ D
Sbjct: 579 VTVGVILLAVVIG--VLLSGRRCGYSKAKQDP-----EEEKMHFHNGHIKLPG-VRTYID 630
Query: 813 PTIYP-----------VLDWNDIKFQDVIGEGNFGQVLKARIKKDGLR-MDAAIKRMKEY 860
P Y ++ + I + VIG G FG+V R+K G R + AIK +K
Sbjct: 631 PHTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVG 690
Query: 861 ASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVL 920
++ RDF GE ++ + H PNII+L G + + EY +G+L FL+K+
Sbjct: 691 YTEKQRRDFLGEASIMGQFDH-PNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKN--- 746
Query: 921 ETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKI 980
D F + QL+ ++ GM YLS ++HRDLAARNIL+ N V K+
Sbjct: 747 --DGQFTVI----------QLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKV 794
Query: 981 ADFGLSR----GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGG 1036
+DFGLSR E G++P+RW A E++ + +T+ SDVWSYG+++WE+VS G
Sbjct: 795 SDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGE 854
Query: 1037 TPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRML 1096
PY MT ++ + + +GYRL P++C +Y LM CW+++ RP F +I+ L++++
Sbjct: 855 RPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKLI 914
Query: 1097 ---EERKTYVNTT 1106
KT VN +
Sbjct: 915 RNPSSLKTLVNAS 927
>gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens]
Length = 885
Score = 215 bits (547), Expect = 2e-55
Identities = 177/603 (29%), Positives = 285/603 (47%), Gaps = 64/603 (10%)
Query: 538 TASIGLPP--PRGLNLLPKSQTTLNLTWQP----IFPS---------SEDDFYVEV-ERR 581
TA+I + P PR L+L+ + T L + W P I+P S+D ++ E
Sbjct: 218 TATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPD 277
Query: 582 SVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVR-ARVNTKAQGEWSEDLTAWTLSDILPP 640
++ VP + + L +LHP Y +R A +++ W+ L T +
Sbjct: 278 PPEEPLTSQASVPPH--QLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLG 335
Query: 641 QPENIKISNITHSSAVISWTILDGYSISSITIRYKVQGKNEDQH---VDVKIKNATITQY 697
PENI + S A + W + + Y++ + +D +D+ ++ +
Sbjct: 336 PPENISATR-NGSQAFVHWQEPRA-PLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLEL 393
Query: 698 QLKGLEPETAYQVDIFAENNIGS-SNPAFSHELVTLPESQAPA-DLGGGKMLLIAILGSA 755
Q G V + G S P + E PA +LL A++ +A
Sbjct: 394 QGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPVKEPSTPAFSWPWWYVLLGAVVAAA 453
Query: 756 GMTCLTVLLAFLIILQLKRAN--------VQRRMAQAFQNVREEPAVQFNSGTL---ALN 804
C+ +L FL+ + K V+R VR+ + + TL ++
Sbjct: 454 ---CVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGIS 510
Query: 805 RKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMK-EYASK 863
++K + +D + + +GEG FG V++ ++ +D + A+K MK ++
Sbjct: 511 EELKEKLRDVM---VDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTR 567
Query: 864 DDHRDFAGELEVLCKLGHHPNIINLLGAC------EHRGYLYLAIEYAPHGNLLDFLRKS 917
+ DF E V K HPN++ L+G C E + + + HG+L FL S
Sbjct: 568 SELEDFLSEA-VCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYS 626
Query: 918 RVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYV 977
R L P + L +Q L+ F AD+A GM+YLS K+FIHRDLAARN ++ EN
Sbjct: 627 R-LGDQPVY---------LPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMS 676
Query: 978 AKIADFGLSR---GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSL 1034
+ADFGLS+ + Y + + ++PV+W+AIESL VYT+ SDVWS+GV +WEI +
Sbjct: 677 VCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATR 736
Query: 1035 GGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNR 1094
G TPY G+ +E+Y+ L QG RL++P +C D +Y LM +CW P +RPSF ++ L
Sbjct: 737 GQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLEN 796
Query: 1095 MLE 1097
L+
Sbjct: 797 TLK 799
>gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens]
Length = 894
Score = 213 bits (543), Expect = 6e-55
Identities = 178/615 (28%), Positives = 288/615 (46%), Gaps = 79/615 (12%)
Query: 538 TASIGLPP--PRGLNLLPKSQTTLNLTWQP----IFPS---------SEDDFYVEV-ERR 581
TA+I + P PR L+L+ + T L + W P I+P S+D ++ E
Sbjct: 218 TATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPD 277
Query: 582 SVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVR-ARVNTKAQGEWSEDLTAWTLSDILPP 640
++ VP + + L +LHP Y +R A +++ W+ L T +
Sbjct: 278 PPEEPLTSQASVPPH--QLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLG 335
Query: 641 QPENIKISNITHSSAVISWTILDGYSISSITIRYKVQGKNEDQH---VDVKIKNATITQY 697
PENI + S A + W + + Y++ + +D +D+ ++ +
Sbjct: 336 PPENISATR-NGSQAFVHWQEPRA-PLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLEL 393
Query: 698 QLKGLEPETAYQVDIFAENNIG--------------SSNPAFSHELVTLPESQAPADLGG 743
Q G V + G + P H+LV P + A
Sbjct: 394 QGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPGQAQPV--HQLVKEPSTPA-FSWPW 450
Query: 744 GKMLLIAILGSAGMTCLTVLLAFLIILQLKRAN--------VQRRMAQAFQNVREEPAVQ 795
+LL A++ +A C+ +L FL+ + K V+R VR+ + +
Sbjct: 451 WYVLLGAVVAAA---CVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRR 507
Query: 796 FNSGTL---ALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDA 852
TL ++ ++K + +D + + +GEG FG V++ ++ +D +
Sbjct: 508 TTEATLNSLGISEELKEKLRDVM---VDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKV 564
Query: 853 AIKRMK-EYASKDDHRDFAGELEVLCKLGHHPNIINLLGAC------EHRGYLYLAIEYA 905
A+K MK ++ + DF E V K HPN++ L+G C E + + +
Sbjct: 565 AVKTMKIAICTRSELEDFLSEA-VCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFM 623
Query: 906 PHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDL 965
HG+L FL SR L P + L +Q L+ F AD+A GM+YLS K+FIHRDL
Sbjct: 624 KHGDLHSFLLYSR-LGDQPVY---------LPTQMLVKFMADIASGMEYLSTKRFIHRDL 673
Query: 966 AARNILVGENYVAKIADFGLSR---GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVW 1022
AARN ++ EN +ADFGLS+ + Y + + ++PV+W+AIESL VYT+ SDVW
Sbjct: 674 AARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVW 733
Query: 1023 SYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYER 1082
S+GV +WEI + G TPY G+ +E+Y+ L QG RL++P +C D +Y LM +CW P +R
Sbjct: 734 SFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDR 793
Query: 1083 PSFAQILVSLNRMLE 1097
PSF ++ L L+
Sbjct: 794 PSFTELREDLENTLK 808
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 211 bits (536), Expect = 4e-54
Identities = 115/296 (38%), Positives = 173/296 (58%), Gaps = 29/296 (9%)
Query: 813 PTIYPV--------LDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKD 864
PT+Y V ++ DI + +G G +G+V KK L + A+K +KE +
Sbjct: 254 PTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTV--AVKTLKEDTMEV 311
Query: 865 DHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDP 924
+ +F E V+ ++ HPN++ LLG C Y+ EY P+GNLLD+LR+ E
Sbjct: 312 E--EFLKEAAVMKEI-KHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREE--- 365
Query: 925 AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFG 984
+++ LL+ A ++ M+YL +K FIHRDLAARN LVGEN+V K+ADFG
Sbjct: 366 -----------VTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFG 414
Query: 985 LSRGQ--EVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGM 1042
LSR + Y + P++W A ESL Y+ ++ SDVW++GVLLWEI + G +PY G+
Sbjct: 415 LSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGI 474
Query: 1043 TCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEE 1098
+++Y+ L +GYR+E+P C +VY+LMR CW+ P +RPSFA+ + M +
Sbjct: 475 DLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHD 530
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 211 bits (536), Expect = 4e-54
Identities = 115/296 (38%), Positives = 173/296 (58%), Gaps = 29/296 (9%)
Query: 813 PTIYPV--------LDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKD 864
PT+Y V ++ DI + +G G +G+V KK L + A+K +KE +
Sbjct: 269 PTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTV--AVKTLKEDTMEV 326
Query: 865 DHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDP 924
+ +F E V+ ++ HPN++ LLG C Y+ EY P+GNLLD+LR+ E
Sbjct: 327 E--EFLKEAAVMKEI-KHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREE--- 380
Query: 925 AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFG 984
+++ LL+ A ++ M+YL +K FIHRDLAARN LVGEN+V K+ADFG
Sbjct: 381 -----------VTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFG 429
Query: 985 LSRGQ--EVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGM 1042
LSR + Y + P++W A ESL Y+ ++ SDVW++GVLLWEI + G +PY G+
Sbjct: 430 LSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGI 489
Query: 1043 TCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEE 1098
+++Y+ L +GYR+E+P C +VY+LMR CW+ P +RPSFA+ + M +
Sbjct: 490 DLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHD 545
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 211 bits (536), Expect = 4e-54
Identities = 115/296 (38%), Positives = 173/296 (58%), Gaps = 29/296 (9%)
Query: 813 PTIYPV--------LDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKD 864
PT+Y V ++ DI + +G G +G+V KK L + A+K +KE +
Sbjct: 248 PTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTV--AVKTLKEDTMEV 305
Query: 865 DHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDP 924
+ +F E V+ ++ HPN++ LLG C Y+ EY P+GNLLD+LR+ E
Sbjct: 306 E--EFLKEAAVMKEI-KHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREE--- 359
Query: 925 AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFG 984
+++ LL+ A ++ M+YL +K FIHRDLAARN LVGEN+V K+ADFG
Sbjct: 360 -----------VTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFG 408
Query: 985 LSRGQ--EVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGM 1042
LSR + Y + P++W A ESL Y+ ++ SDVW++GVLLWEI + G +PY G+
Sbjct: 409 LSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGI 468
Query: 1043 TCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEE 1098
+++Y+ L +GYR+E+P C +VY+LMR CW+ P +RPSFA+ + M +
Sbjct: 469 DLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHD 524
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.423
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,769,326
Number of Sequences: 37866
Number of extensions: 2358145
Number of successful extensions: 11564
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 665
Number of HSP's successfully gapped in prelim test: 520
Number of HSP's that attempted gapping in prelim test: 5263
Number of HSP's gapped (non-prelim): 3517
length of query: 1124
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1011
effective length of database: 13,968,660
effective search space: 14122315260
effective search space used: 14122315260
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.