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Search of human proteins with 7662260
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7662260 kelch repeat and BTB (POZ) domain containing 11
[Homo sapiens]
(623 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7662260 kelch repeat and BTB (POZ) domain containing 11 [Homo... 1267 0.0
gi|206597556 kelch domain containing 7B [Homo sapiens] 313 4e-85
gi|116089333 kelch domain containing 7A [Homo sapiens] 287 2e-77
gi|55749726 kelch domain containing 5 [Homo sapiens] 125 9e-29
gi|55925604 kelch-like 18 [Homo sapiens] 110 5e-24
gi|55925608 kelch-like 21 [Homo sapiens] 104 2e-22
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 96 1e-19
gi|24308181 kelch-like 9 [Homo sapiens] 93 6e-19
gi|40807500 kelch-like 20 [Homo sapiens] 93 8e-19
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 91 3e-18
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 91 3e-18
gi|45643138 kelch-like 13 [Homo sapiens] 89 2e-17
gi|38194229 kelch-like 17 [Homo sapiens] 88 3e-17
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 86 1e-16
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 86 1e-16
gi|157384932 hypothetical protein LOC390594 [Homo sapiens] 85 2e-16
gi|23397572 kelch-like 34 [Homo sapiens] 84 4e-16
gi|14780904 kelch-like 1 protein [Homo sapiens] 82 2e-15
gi|31542246 kelch-like 36 [Homo sapiens] 82 2e-15
gi|158508542 kelch-like 33 [Homo sapiens] 81 3e-15
gi|8922854 kelch-like 26 [Homo sapiens] 81 3e-15
gi|24432026 kelch-like [Homo sapiens] 80 6e-15
gi|156616301 kelch-like 32 [Homo sapiens] 80 7e-15
gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo... 79 1e-14
gi|40018614 DRE1 protein [Homo sapiens] 79 1e-14
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 78 2e-14
gi|128485503 kelch-like 30 [Homo sapiens] 78 2e-14
gi|55741643 kelch-like 14 [Homo sapiens] 77 4e-14
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 75 1e-13
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 75 1e-13
>gi|7662260 kelch repeat and BTB (POZ) domain containing 11 [Homo
sapiens]
Length = 623
Score = 1267 bits (3278), Expect = 0.0
Identities = 623/623 (100%), Positives = 623/623 (100%)
Query: 1 MEHAVAPCVLYPGTEPGAAGESESEGAASPAQTPCSLGASLCFSSGEESPPQSLASAAEG 60
MEHAVAPCVLYPGTEPGAAGESESEGAASPAQTPCSLGASLCFSSGEESPPQSLASAAEG
Sbjct: 1 MEHAVAPCVLYPGTEPGAAGESESEGAASPAQTPCSLGASLCFSSGEESPPQSLASAAEG 60
Query: 61 AATSPPSSGGPRVVERQWEAGSAGAASPEELASPEERACPEEPAAPSPEPRVWLEDPASP 120
AATSPPSSGGPRVVERQWEAGSAGAASPEELASPEERACPEEPAAPSPEPRVWLEDPASP
Sbjct: 61 AATSPPSSGGPRVVERQWEAGSAGAASPEELASPEERACPEEPAAPSPEPRVWLEDPASP 120
Query: 121 EEPGEPAPVPPGFGAVYGEPDLVLEVSGRRLRAHKAVLAARSDYFRARASRDVLRVQGVS 180
EEPGEPAPVPPGFGAVYGEPDLVLEVSGRRLRAHKAVLAARSDYFRARASRDVLRVQGVS
Sbjct: 121 EEPGEPAPVPPGFGAVYGEPDLVLEVSGRRLRAHKAVLAARSDYFRARASRDVLRVQGVS 180
Query: 181 LTALRLLLADAYSGRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVL 240
LTALRLLLADAYSGRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVL
Sbjct: 181 LTALRLLLADAYSGRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVL 240
Query: 241 SAAKRQRLNELRDAAYCFMSDHYLEVLREPAVFGRLSGAERDLLLRRRLRAGRAHLLAAA 300
SAAKRQRLNELRDAAYCFMSDHYLEVLREPAVFGRLSGAERDLLLRRRLRAGRAHLLAAA
Sbjct: 241 SAAKRQRLNELRDAAYCFMSDHYLEVLREPAVFGRLSGAERDLLLRRRLRAGRAHLLAAA 300
Query: 301 LGPAGERAGSRPQSPSGDADARGDAAVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNY 360
LGPAGERAGSRPQSPSGDADARGDAAVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNY
Sbjct: 301 LGPAGERAGSRPQSPSGDADARGDAAVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNY 360
Query: 361 LFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGE 420
LFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGE
Sbjct: 361 LFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGE 420
Query: 421 CLLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGGSLFYRLLKYDPRRDEW 480
CLLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGGSLFYRLLKYDPRRDEW
Sbjct: 421 CLLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGGSLFYRLLKYDPRRDEW 480
Query: 481 QECPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAP 540
QECPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAP
Sbjct: 481 QECPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAP 540
Query: 541 LRLPGGPTGLQPFRCAALDGAIYCVSRAGTWRFQPAREGEAGGDAGQGGGFEALGAPLDV 600
LRLPGGPTGLQPFRCAALDGAIYCVSRAGTWRFQPAREGEAGGDAGQGGGFEALGAPLDV
Sbjct: 541 LRLPGGPTGLQPFRCAALDGAIYCVSRAGTWRFQPAREGEAGGDAGQGGGFEALGAPLDV 600
Query: 601 RGVLIPFALSLPEKPPRGEQGAP 623
RGVLIPFALSLPEKPPRGEQGAP
Sbjct: 601 RGVLIPFALSLPEKPPRGEQGAP 623
>gi|206597556 kelch domain containing 7B [Homo sapiens]
Length = 594
Score = 313 bits (801), Expect = 4e-85
Identities = 227/620 (36%), Positives = 298/620 (48%), Gaps = 73/620 (11%)
Query: 21 ESESEGAASPAQTPCSLGASLCFSSGEESPPQSLASAAEGAATSPPSSGGPRVVERQWEA 80
+ +G+ A +G S S + P S G T G + R E
Sbjct: 11 QDRPQGSVPRAVPGSPVGPSTSTHSEDRHGPSSSVGTVIGTGTGGLVEAGGQPQPRSSET 70
Query: 81 GSAGAASPEELASPEERACPEEPAAPSPEPRVWLEDPASPEEPGEPAPVPPGFGAVYGEP 140
G+ SP+ E+ P P+ + P P +P PA PPG A
Sbjct: 71 N--GSPSPDPPPGLRGEGTREKSLDPLPQAAM----PRGPAQP--PAQRPPG-PAASSSA 121
Query: 141 DLVLEVSGRRLRAHKAVLAARSDYFRARASRDVLRVQGVSLTALRLLLADAYSGRMAGVR 200
V R R+ + + R AS D QG A G AG R
Sbjct: 122 RRSQPVPQLRKRSRCEIAPSSEQEVRPAASGDP---QGE---------APGEGGSPAG-R 168
Query: 201 PDNVAEVVAGARRL----QLPGA----------AQRATD-----AVGPQLSLANCYEVLS 241
+ E AR+L Q PG + RA + A+ +L L +C +VL+
Sbjct: 169 SGALTEKQEEARKLMVFLQRPGGWGVVEGPRKPSSRALEPATAAALRRRLDLGSCLDVLA 228
Query: 242 AAKRQRLNELRDAAYCFMSDHYLEVLREPAVFGRLSGAERDLLLRRRLRAGRAHLLAAAL 301
A++ L Y MSD+ L VL +P ++ RLS A+R+ +L R GRA L L
Sbjct: 229 FAQQHGEPGLAQETYALMSDNLLRVLGDPCLYRRLSAADRERILSLRTGRGRAVLGVLVL 288
Query: 302 ------GPAGERAGSRPQSPSGDADARGD--AAVYCFHAAAGEWRELTRLPEGAPARGCG 353
G +G G R + P A A ++ F+ WR LT++PE AP RGCG
Sbjct: 289 PSLYQGGRSGLPRGPRGEEPPAAAPVSLPLPAHLHVFNPRENTWRPLTQVPEEAPLRGCG 348
Query: 354 LCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGH 413
LC ++NYLF+AGG+ +G +A S++VFCYNP T+ WS VRP++QAR+QL+L+ALDG
Sbjct: 349 LCTMHNYLFLAGGIRGSG--AKAVCSNEVFCYNPLTNIWSQVRPMQQARAQLKLVALDGL 406
Query: 414 LYAVGGECLLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGGSLFYRLLKY 473
LYA+GGECL S+E YDPR D W P APLP G F VAHEA C G+IYV+GG LFYRLL+Y
Sbjct: 407 LYAIGGECLYSMECYDPRTDAWTPRAPLPAGTFPVAHEAVACRGDIYVTGGHLFYRLLRY 466
Query: 474 DPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAAGPSGVSVSRYHCLAKQ 533
P +D W ECP S+S RS+D+VAL GF+YRFDL RG G +V RY+ +
Sbjct: 467 SPVKDAWDECPYSASHRRSSDIVALGGFLYRFDL--LRG-------VGAAVMRYNTVTGS 517
Query: 534 WSPCVA-PLRLPGGPTGLQPFRCAALDGAIYCVSRAGTWRFQPAREGEAGGDAGQGGGFE 592
WS + PL P P C L IYC++ T F G Q E
Sbjct: 518 WSRAASLPLPAPA------PLHCTTLGNTIYCLNPQVTATF------TVSGGTAQFQAKE 565
Query: 593 ALGAPLDVRGVLIPFALSLP 612
PL GVL PF L+LP
Sbjct: 566 LQPFPLGSTGVLSPFILTLP 585
>gi|116089333 kelch domain containing 7A [Homo sapiens]
Length = 777
Score = 287 bits (734), Expect = 2e-77
Identities = 166/368 (45%), Positives = 212/368 (57%), Gaps = 43/368 (11%)
Query: 208 VAGARRLQLPGAAQRATDAVGPQ--LSLANCYEVLSAAKRQRLNELRDAAYCFMSDHYLE 265
VAG +P T A PQ L L NCYEVL+ AKRQ L L++AAY MS++YL+
Sbjct: 410 VAGTNFFHIP-----LTPASAPQVRLDLGNCYEVLTLAKRQNLEALKEAAYKVMSENYLQ 464
Query: 266 VLREPAVFGRLSGAERDLLLRRRLRAGRAHLLAAALGPAGERAGSRPQSPSGDADARGDA 325
VLR P ++G LSGAER+L+L+RRLR GR +L+ A + P + G
Sbjct: 465 VLRSPDIYGCLSGAERELILQRRLR-GRQYLVVADVCPKEDSGG---------------- 507
Query: 326 AVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCY 385
+ C+ WR L R+P A +RGC +C L+NYLFV G G +PS +VFCY
Sbjct: 508 -LCCYDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGH----QPSSRVFCY 562
Query: 386 NPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGECLLSVERYDPRADRWAPVAPLPRGA 445
NP T WS V PL QAR RL+ALDGHLYA+GGECL SVERYDPR DRW PLP
Sbjct: 563 NPLTGIWSEVCPLNQARPHCRLVALDGHLYAIGGECLNSVERYDPRLDRWDFAPPLPSDT 622
Query: 446 FAVAHEATTCHGEIYVSGGSLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRF 505
FA+AH AT EI+V+GGSL + L ++ + W P S++R+A+MVA++GF+YRF
Sbjct: 623 FALAHTATVRAKEIFVTGGSLRFLLFRFSAQEQRWWAGPTGGSKDRTAEMVAVNGFLYRF 682
Query: 506 DLSGSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAPLRLPGGPTGLQPFRCAALDGAIYCV 565
DL+ S G++V R + W C A R P F+CA +D IYCV
Sbjct: 683 DLNRS---------LGIAVYRCSASTRLWYEC-ATYRTPYP----DAFQCAVVDNLIYCV 728
Query: 566 SRAGTWRF 573
R T F
Sbjct: 729 GRRSTLCF 736
>gi|55749726 kelch domain containing 5 [Homo sapiens]
Length = 505
Score = 125 bits (315), Expect = 9e-29
Identities = 130/460 (28%), Positives = 196/460 (42%), Gaps = 70/460 (15%)
Query: 155 KAVLAARSDYFRA-------------RASRDVLRVQGVSLTALRLLL-----ADAYSGRM 196
K L +SDYFRA +V +++G+S LRL+L A G +
Sbjct: 20 KRKLIEQSDYFRALYRSGMREALSQEAGGPEVQQLRGLSAPGLRLVLDFINAGGAREGWL 79
Query: 197 AGVRPDN---------------VAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLS 241
G R + ++E+V A LQ+ Q Q+ L NC E+
Sbjct: 80 LGPRGEKGGGVDEDEEMDEVSLLSELVEAASFLQVTSLLQLLLS----QVRLNNCLEMYR 135
Query: 242 AAKRQRLNELRDAAYCFMSDHYLEVLREPA--VFGRLSGAERDLLLRRRLRAGRAHLLAA 299
A+ L +L++A FM H+ EVL +P + G A D+ L++RLR R
Sbjct: 136 LAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLLGSPPQAPGDVSLKQRLREARM-TGTP 194
Query: 300 ALGPAGERAGSRPQSPSGDADARGDA-AVYCFHAAAGEWRELTRL--PEGAPARGCGLCV 356
L G+ G P +G+ ++ + W L P+ RG G +
Sbjct: 195 VLVALGDFLGG----PLAPHPYQGEPPSMLRYEEMTERWFPLANNLPPDLVNVRGYGSAI 250
Query: 357 LYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYA 416
L NYLF+ GG + A S YNP+T+ W V + Q RS +L+A++ LYA
Sbjct: 251 LDNYLFIVGGYRITSQEISAAHS-----YNPSTNEWLQVASMNQKRSNFKLVAVNSKLYA 305
Query: 417 VGGECLLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGG----SLFYRLLK 472
+GG+ + +VE Y+P D W VAPLP A C G+IYV GG +L+
Sbjct: 306 IGGQAVSNVECYNPEQDAWNFVAPLPNP--LAEFSACECKGKIYVIGGYTTRDRNMNILQ 363
Query: 473 YDPRRDEWQECPCSSSRERSADMVALDGFIY-----RFDLSGSRGEAQAAGPSGVSVSRY 527
Y P D W R MV+++ IY +L +R +Q+ ++V Y
Sbjct: 364 YCPSSDMWTLFETCDVHIRKQQMVSVEETIYIVGGCLHELGPNRRSSQS--EDMLTVQSY 421
Query: 528 HCLAKQWSPCVAPLRLPGGPTGLQPFRCAALDGAIYCVSR 567
+ + +QW L+ +GL CA + IY +SR
Sbjct: 422 NTVTRQW----LYLKENTSKSGLN-LTCALHNDGIYIMSR 456
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 110 bits (274), Expect = 5e-24
Identities = 119/465 (25%), Positives = 180/465 (38%), Gaps = 59/465 (12%)
Query: 141 DLVLEVSGRRLRAHKAVLAARSDYFRARASRDVLR-------VQGVSLTALRLLLADAYS 193
D+ L++ + AH+ VLAA YF A + D++ +QG+ +AL L+ AY+
Sbjct: 39 DVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYN 98
Query: 194 GRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRD 253
G +A + NV ++ GA LQL + +L NC V A+ L D
Sbjct: 99 GNLA-IDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFAETMMCAVLYD 157
Query: 254 AAYCFMSDHYLEVLREPAVFGRLSGAERDLLLRRRLRA-GRAHLLAAALGPAG-ERAGSR 311
AA F+ H++EV +L+ R L + AAL +R
Sbjct: 158 AANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRG 217
Query: 312 PQSPSGDADAR--------------GDAAVYCFHAA---AGEWRELTRLPEGAP------ 348
P P ++ R D V C H E ++ +PE P
Sbjct: 218 PYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMPERRPHLPAFR 277
Query: 349 ARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLL 408
R + ++ GG+ AG + V ++P + W RP+ ARS++ +
Sbjct: 278 TRPRCCTSIAGLIYAVGGLNSAGDS-----LNVVEVFDPIANCWERCRPMTTARSRVGVA 332
Query: 409 ALDGHLYAVGGEC----LLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGG 464
++G LYA+GG L +VE Y+P D W V + A+ G+IYV GG
Sbjct: 333 VVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMG--TVVLDGQIYVCGG 390
Query: 465 ----SLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAAGPS 520
S + Y P D+W SS +A + +G IY +SG Q
Sbjct: 391 YDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIY---VSGGHDGLQIFS-- 445
Query: 521 GVSVSRYHCLAKQWSPCVAPL----RLPGGPTGLQPFRCAALDGA 561
SV Y+ W P L R G + F C DG+
Sbjct: 446 --SVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGS 488
Score = 52.4 bits (124), Expect = 1e-06
Identities = 34/93 (36%), Positives = 45/93 (48%), Gaps = 10/93 (10%)
Query: 353 GLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDG 412
G L + +FV GG +G A Y+ D W + P+ RS++ L+A G
Sbjct: 471 GAASLGSKMFVCGGYDGSGFLSIAE------MYSSVADQWCLIVPMHTRRSRVSLVASCG 524
Query: 413 HLYAVGG----ECLLSVERYDPRADRWAPVAPL 441
LYAVGG L SVE YDP D W +AP+
Sbjct: 525 RLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPM 557
>gi|55925608 kelch-like 21 [Homo sapiens]
Length = 597
Score = 104 bits (260), Expect = 2e-22
Identities = 125/432 (28%), Positives = 173/432 (40%), Gaps = 101/432 (23%)
Query: 141 DLVLEVSGRR-LRAHKAVLAARSDYFRA------RASR-DVLRVQGVSLTALRLLLADAY 192
D+ LE +G R AH+AVLAA S YFRA R SR + +R+ GV L+LLL +Y
Sbjct: 36 DVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSY 95
Query: 193 SGRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEV------------L 240
+GR+A V DN ++ A LQ P + + QL LANC ++
Sbjct: 96 TGRVA-VSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDMQDFAEAFSCSGLA 154
Query: 241 SAAKR--------------------QRLNELRDAAYCFMSDH------------------ 262
SAA+R + L LRD C +
Sbjct: 155 SAAQRFILRHVGELGAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRA 214
Query: 263 -----YLEVLREPAV--FGRLSGAERDLLLRR-----RLRAGRAHLLAAALG--PAGERA 308
LE +R P V F L+ E + L+ R RL AA G
Sbjct: 215 AHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARDFQAARYDRHDRGPCP 274
Query: 309 GSRPQSPSG-----------DADARGDAAVYCFHAAAGEWRELTRLPEGAPARGCGLCVL 357
RP+ +G D D V C++ G+WR L P+ G + L
Sbjct: 275 RMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGG-GYSIVAL 333
Query: 358 YNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAV 417
N ++V GG DG +R D V+ YN + + W+ V P+ +AR LDG LY V
Sbjct: 334 GNDIYVTGG-----SDG-SRLYDCVWRYNSSVNEWAEVAPMLKAREYHSSSVLDGLLYVV 387
Query: 418 GGECLLSVERYDPRADRWAPVAPLPRGAFAVAHEATT-CHGEIYVSG---GSLFYRLLKY 473
+ S ERYD D W + P+ + + + +TT C G +Y G G + Y
Sbjct: 388 AAD---STERYDHTTDSWEALQPM---TYPMDNCSTTACRGRLYAIGSLAGKETMVMQCY 441
Query: 474 DPRRDEWQECPC 485
DP D W C
Sbjct: 442 DPDTDLWSLVDC 453
Score = 41.6 bits (96), Expect = 0.002
Identities = 25/73 (34%), Positives = 30/73 (41%), Gaps = 5/73 (6%)
Query: 379 SDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGG-----ECLLSVERYDPRAD 433
S +V YNP + W + + Q L L G LY GG E VE YDP
Sbjct: 479 SAEVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETR 538
Query: 434 RWAPVAPLPRGAF 446
W+ V LP F
Sbjct: 539 AWSVVGRLPEPTF 551
Score = 29.6 bits (65), Expect = 8.7
Identities = 22/71 (30%), Positives = 32/71 (45%), Gaps = 7/71 (9%)
Query: 325 AAVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFC 384
A V ++ EW ++ + + G L VL L+V+GG D SD V
Sbjct: 480 AEVDVYNPTRNEWDKIPSMNQVHV--GGSLAVLGGKLYVSGGY-----DNTFELSDVVEA 532
Query: 385 YNPATDSWSAV 395
Y+P T +WS V
Sbjct: 533 YDPETRAWSVV 543
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 95.5 bits (236), Expect = 1e-19
Identities = 71/233 (30%), Positives = 111/233 (47%), Gaps = 28/233 (12%)
Query: 344 PEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRA--RPSDQVFCYNPATDSWSAVRPLRQA 401
P P G+CVL ++V GG+A G + + V C+NP T++W+++ + ++
Sbjct: 316 PLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLERMNES 375
Query: 402 RSQLRLLALDGHLYAVGG----ECLLSVERYDPRADRWAPVAPL--PRGAFAVAHEATTC 455
RS L ++ L G LYA+GG L SVE+Y P+ +W PVAP+ R FA A
Sbjct: 376 RSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFA----AAVL 431
Query: 456 HGEIYVSGG---SLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSGSRG 512
G IY GG + + +YDP +D W+ + + + + GFI F + G G
Sbjct: 432 DGMIYAIGGYGPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFI--FVVGGHNG 489
Query: 513 EAQAAGPSGVSVSRYHCLAKQWSPCVAPLRLPGGPTGLQPFRCAALDGAIYCV 565
+ + S+ RY QW+ C P++ P G A +D +Y V
Sbjct: 490 VSHLS-----SIERYDPHQNQWTVC-RPMKEPRTGVG-----AAVIDNYLYVV 531
Score = 57.4 bits (137), Expect = 4e-08
Identities = 42/140 (30%), Positives = 58/140 (41%), Gaps = 18/140 (12%)
Query: 350 RGC-GLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLL 408
R C VL ++ GG PA + R Y+P+ DSW V + R +
Sbjct: 423 RSCFAAAVLDGMIYAIGGYGPAHMNSVER-------YDPSKDSWEMVASMADKRIHFGVG 475
Query: 409 ALDGHLYAVGGEC----LLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGG 464
+ G ++ VGG L S+ERYDP ++W P+ V A +YV GG
Sbjct: 476 VMLGFIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVG--AAVIDNYLYVVGG 533
Query: 465 ----SLFYRLLKYDPRRDEW 480
S + KYDP D W
Sbjct: 534 HSGSSYLNTVQKYDPISDTW 553
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 93.2 bits (230), Expect = 6e-19
Identities = 85/299 (28%), Positives = 126/299 (42%), Gaps = 27/299 (9%)
Query: 334 AGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWS 393
A EWR L P AP G+ V+ N+L+V GG + G+ D VF ++P + W
Sbjct: 324 AQEWRSLA--PMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAV-DTVFRFDPRYNKWM 380
Query: 394 AVRPLRQARSQLRLLALDGHLYAVGGEC----LLSVERYDPRADRWAPVAPLPRGAFAVA 449
V L + R+ L AL GHLYAVGG L +VE Y+PR + W+ VA + +
Sbjct: 381 QVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHY--G 438
Query: 450 HEATTCHGEIYVSGG----SLFYRLLKYDPRRDEW-QECPCSSSRERSADMVALDGFIYR 504
H T G +Y+SGG + L+ +DP D+W Q+ P ++ R D
Sbjct: 439 HAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKL--- 495
Query: 505 FDLSGSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAPLRLPGGPTGLQPFRCAALDGAIYC 564
+ + G+ + +S Y QW+P A LR G A + IY
Sbjct: 496 YVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLR------GQSDVGVAVFENKIYV 549
Query: 565 VSRAGTWRFQPAREGEAGGDAGQGGGFEALGAPLDVRGVLIPFALSLPEKPPRGEQGAP 623
V +W + E D + + P + G+ A +L PP G+P
Sbjct: 550 VG-GYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIR---ACTLTVFPPEENPGSP 604
Score = 42.0 bits (97), Expect = 0.002
Identities = 30/115 (26%), Positives = 48/115 (41%), Gaps = 15/115 (13%)
Query: 379 SDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGE---------CLLSVERYD 429
S ++ Y+ W ++ P+ R Q + + LY VGG+ + +V R+D
Sbjct: 314 SKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFD 373
Query: 430 PRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGGSLFYRLLK----YDPRRDEW 480
PR ++W VA L + G +Y GG L Y+PR +EW
Sbjct: 374 PRYNKWMQVASL--NEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEW 426
Score = 35.8 bits (81), Expect = 0.12
Identities = 26/105 (24%), Positives = 52/105 (49%), Gaps = 8/105 (7%)
Query: 154 HKAVLAARSDYFRARASRDV-------LRVQGVSLTALRLLLADAYSGRMAGVRPDNVAE 206
H+A++A+ SDYF+A + + +++ GV+ L+ ++ Y+ +++ + DN+ +
Sbjct: 66 HRAMMASASDYFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLS-LNMDNLQD 124
Query: 207 VVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNEL 251
+ A LQ+ + +SL NC EV A L E+
Sbjct: 125 TLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEV 169
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 92.8 bits (229), Expect = 8e-19
Identities = 121/472 (25%), Positives = 189/472 (40%), Gaps = 75/472 (15%)
Query: 141 DLVLEVSGRRLRAHKAVLAARSDYFRARASRDVLR-------VQGVSLTALRLLLADAYS 193
D+VL V +++ AH+ +L+A S YFRA + ++ ++ + A+ LL+ AY+
Sbjct: 69 DVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYT 128
Query: 194 GRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRD 253
++ V NV ++ A LQL + + + QL +NC + + A EL
Sbjct: 129 SQIT-VEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFADTHSCRELLR 187
Query: 254 AAYCFMSDHYLEVLR-------------------------EPAVFGRLSGAERDLLLRRR 288
A F ++ EV+ E VF + + + RR
Sbjct: 188 IADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERR 247
Query: 289 LRAGRA--HLLAAALGP--AGERAGSRPQSPSGDADARGDAAVYCFHAAAGEWRELTRLP 344
+ + H+ L P GS P S D + R + + R L + P
Sbjct: 248 PQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKS-DEECRDLVDEAKNYLLLPQERPLMQGP 306
Query: 345 EGAPAR--GCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQAR 402
P + CG LF GG G A S V Y+P T+ W V + + R
Sbjct: 307 RTRPRKPIRCG-----EVLFAVGGWC----SGDAISS--VERYDPQTNEWRMVASMSKRR 355
Query: 403 SQLRLLALDGHLYAVGG----ECLLSVERYDPRADRW-APVAPLPRGAFAVAHEATTCHG 457
+ + LD LYAVGG L SVERYDP+ ++W + VAP +V G
Sbjct: 356 CGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVG--VAVLGG 413
Query: 458 EIYVSGG----SLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSGSRGE 513
+Y GG S + +YDP+ ++W S+R + L GF+Y + GS G
Sbjct: 414 FLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYA--VGGSDGT 471
Query: 514 AQAAGPSGVSVSRYHCLAKQWSPCVAPLRLPGGPTGLQPFRCAALDGAIYCV 565
+ +V RY+ +W +AP+ T + CA IY V
Sbjct: 472 SPLN-----TVERYNPQENRWH-TIAPM-----GTRRKHLGCAVYQDMIYAV 512
Score = 79.7 bits (195), Expect = 7e-15
Identities = 79/272 (29%), Positives = 111/272 (40%), Gaps = 40/272 (14%)
Query: 323 GDA--AVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSD 380
GDA +V + EWR + + + G G+ VL + L+ GG DG + +
Sbjct: 329 GDAISSVERYDPQTNEWRMVASMSKRRC--GVGVSVLDDLLYAVGG-----HDGSSY-LN 380
Query: 381 QVFCYNPATDSWSA-VRPLRQARSQLRLLALDGHLYAVGGE----CLLSVERYDPRADRW 435
V Y+P T+ WS+ V P R+ + + L G LYAVGG+ CL VERYDP+ ++W
Sbjct: 381 SVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKW 440
Query: 436 APVAPLPRGAFAVAHEATTCHGEIYVSGG----SLFYRLLKYDPRRDEWQECPCSSSRER 491
VA + VA G +Y GG S + +Y+P+ + W +R +
Sbjct: 441 TRVASMSTRRLGVA--VAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRK 498
Query: 492 SADMVALDGFIYRFDLSGSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAPLRLPGGPTGL- 550
IY G R + S RY+ QWSP VA G GL
Sbjct: 499 HLGCAVYQDMIYAV---GGRDDTTELS----SAERYNPRTNQWSPVVAMTSRRSG-VGLA 550
Query: 551 ----QPFRCAALDGAIYCVS------RAGTWR 572
Q DG Y + A TWR
Sbjct: 551 VVNGQLMAVGGFDGTTYLKTIEVFDPDANTWR 582
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 90.9 bits (224), Expect = 3e-18
Identities = 101/448 (22%), Positives = 177/448 (39%), Gaps = 63/448 (14%)
Query: 141 DLVLEVSGRRLRAHKAVLAARSDYFRARASRDV-------LRVQGVSLTALRLLLADAYS 193
D++L RR+ AH+ VL++ SDYF A + DV ++++GV +L L+ AY+
Sbjct: 175 DVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYT 234
Query: 194 GRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRD 253
GR+ ++ DN+ +++ A LQL + + QL +NC + S A Q +L
Sbjct: 235 GRLE-LKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHK 293
Query: 254 AAYCFMSDHYLEVLR--------------------------EPAVFGRLSGAERDLLLRR 287
A+ + +H++EV+R E + L+ DL RR
Sbjct: 294 VAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRR 353
Query: 288 R-LRAGRAHLLAAALGPAGERAGSRPQSPSGDADARGDAAVYCFHAAAGEWRELTRLPEG 346
+ L A++ L P D + + + E R + + P
Sbjct: 354 KDLSKLLAYIRLPLLAPQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRT 413
Query: 347 APARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLR 406
P + LF GG+ + + + Y+ T+ W+ V + R Q
Sbjct: 414 KPRKS-----TVGTLFAVGGM------DSTKGATSIEKYDLRTNMWTPVANMNGRRLQFG 462
Query: 407 LLALDGHLYAVGG----ECLLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVS 462
+ LD LY VGG + L +VE Y+P+ W+ + P+ + G +Y
Sbjct: 463 VAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLG--VAVLEGPMYAV 520
Query: 463 GG----SLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAAG 518
GG S + ++DP+ +W S+ + + L G +Y + G G +
Sbjct: 521 GGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYA--VGGRDGSSCLK- 577
Query: 519 PSGVSVSRYHCLAKQWSPCVAPLRLPGG 546
SV + +W+ C + GG
Sbjct: 578 ----SVECFDPHTNKWTLCAQMSKRRGG 601
Score = 77.0 bits (188), Expect = 5e-14
Identities = 55/161 (34%), Positives = 79/161 (49%), Gaps = 20/161 (12%)
Query: 353 GLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDG 412
G+ VL + L+V GG DG + + V CYNP T +WS + P+ R L + L+G
Sbjct: 462 GVAVLDDKLYVVGG-----RDG-LKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEG 515
Query: 413 HLYAVGG----ECLLSVERYDPRADRWAPVAPL--PRGAFAVAHEATTCHGEIYVSGGSL 466
+YAVGG L +VER+DP+A +W VA + PR VA G++Y GG
Sbjct: 516 PMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVA----VLSGKLYAVGGRD 571
Query: 467 FYRLLK----YDPRRDEWQECPCSSSRERSADMVALDGFIY 503
LK +DP ++W C S R + +G +Y
Sbjct: 572 GSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLY 612
Score = 60.5 bits (145), Expect = 5e-09
Identities = 40/123 (32%), Positives = 58/123 (47%), Gaps = 6/123 (4%)
Query: 326 AVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCY 385
+V CF +W ++ + G G+ L+ GG + +R SD V Y
Sbjct: 578 SVECFDPHTNKWTLCAQMSKRRG--GVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERY 635
Query: 386 NPATDSWSAVRPLRQARSQLRLLALDGHLYAVGG----ECLLSVERYDPRADRWAPVAPL 441
+P TD W+AV + +R + + L LYAVGG L +VE YDP+ + W VAPL
Sbjct: 636 DPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPL 695
Query: 442 PRG 444
G
Sbjct: 696 CLG 698
Score = 30.4 bits (67), Expect = 5.1
Identities = 18/51 (35%), Positives = 28/51 (54%), Gaps = 6/51 (11%)
Query: 353 GLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARS 403
G+C+L + L+ GG DG+A + V Y+P T+ W+ V PL R+
Sbjct: 656 GVCLLGDKLYAVGGY-----DGQAY-LNTVEAYDPQTNEWTQVAPLCLGRA 700
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 90.9 bits (224), Expect = 3e-18
Identities = 101/448 (22%), Positives = 177/448 (39%), Gaps = 63/448 (14%)
Query: 141 DLVLEVSGRRLRAHKAVLAARSDYFRARASRDV-------LRVQGVSLTALRLLLADAYS 193
D++L RR+ AH+ VL++ SDYF A + DV ++++GV +L L+ AY+
Sbjct: 221 DVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYT 280
Query: 194 GRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRD 253
GR+ ++ DN+ +++ A LQL + + QL +NC + S A Q +L
Sbjct: 281 GRLE-LKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHK 339
Query: 254 AAYCFMSDHYLEVLR--------------------------EPAVFGRLSGAERDLLLRR 287
A+ + +H++EV+R E + L+ DL RR
Sbjct: 340 VAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRR 399
Query: 288 R-LRAGRAHLLAAALGPAGERAGSRPQSPSGDADARGDAAVYCFHAAAGEWRELTRLPEG 346
+ L A++ L P D + + + E R + + P
Sbjct: 400 KDLSKLLAYIRLPLLAPQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRT 459
Query: 347 APARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLR 406
P + LF GG+ + + + Y+ T+ W+ V + R Q
Sbjct: 460 KPRKS-----TVGTLFAVGGM------DSTKGATSIEKYDLRTNMWTPVANMNGRRLQFG 508
Query: 407 LLALDGHLYAVGG----ECLLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVS 462
+ LD LY VGG + L +VE Y+P+ W+ + P+ + G +Y
Sbjct: 509 VAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLG--VAVLEGPMYAV 566
Query: 463 GG----SLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAAG 518
GG S + ++DP+ +W S+ + + L G +Y + G G +
Sbjct: 567 GGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYA--VGGRDGSSCLK- 623
Query: 519 PSGVSVSRYHCLAKQWSPCVAPLRLPGG 546
SV + +W+ C + GG
Sbjct: 624 ----SVECFDPHTNKWTLCAQMSKRRGG 647
Score = 77.0 bits (188), Expect = 5e-14
Identities = 55/161 (34%), Positives = 79/161 (49%), Gaps = 20/161 (12%)
Query: 353 GLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDG 412
G+ VL + L+V GG DG + + V CYNP T +WS + P+ R L + L+G
Sbjct: 508 GVAVLDDKLYVVGG-----RDG-LKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEG 561
Query: 413 HLYAVGG----ECLLSVERYDPRADRWAPVAPL--PRGAFAVAHEATTCHGEIYVSGGSL 466
+YAVGG L +VER+DP+A +W VA + PR VA G++Y GG
Sbjct: 562 PMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVA----VLSGKLYAVGGRD 617
Query: 467 FYRLLK----YDPRRDEWQECPCSSSRERSADMVALDGFIY 503
LK +DP ++W C S R + +G +Y
Sbjct: 618 GSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLY 658
Score = 60.5 bits (145), Expect = 5e-09
Identities = 40/123 (32%), Positives = 58/123 (47%), Gaps = 6/123 (4%)
Query: 326 AVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCY 385
+V CF +W ++ + G G+ L+ GG + +R SD V Y
Sbjct: 624 SVECFDPHTNKWTLCAQMSKRRG--GVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERY 681
Query: 386 NPATDSWSAVRPLRQARSQLRLLALDGHLYAVGG----ECLLSVERYDPRADRWAPVAPL 441
+P TD W+AV + +R + + L LYAVGG L +VE YDP+ + W VAPL
Sbjct: 682 DPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPL 741
Query: 442 PRG 444
G
Sbjct: 742 CLG 744
Score = 30.4 bits (67), Expect = 5.1
Identities = 18/51 (35%), Positives = 28/51 (54%), Gaps = 6/51 (11%)
Query: 353 GLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARS 403
G+C+L + L+ GG DG+A + V Y+P T+ W+ V PL R+
Sbjct: 702 GVCLLGDKLYAVGGY-----DGQAY-LNTVEAYDPQTNEWTQVAPLCLGRA 746
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 88.6 bits (218), Expect = 2e-17
Identities = 73/241 (30%), Positives = 109/241 (45%), Gaps = 23/241 (9%)
Query: 334 AGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWS 393
A EW+ L P AP G+ V+ N+L+V GG + G+ D VF ++P + W
Sbjct: 366 AHEWKSLA--PMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAV-DTVFRFDPRYNKWM 422
Query: 394 AVRPLRQARSQLRLLALDGHLYAVGGEC----LLSVERYDPRADRWAPVAPLPRGAFAVA 449
V L + R+ L AL G+LYAVGG L +VE Y+PR + W VA + +
Sbjct: 423 QVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHY--G 480
Query: 450 HEATTCHGEIYVSGG----SLFYRLLKYDPRRDEW-QECPCSSSRERSADMVALDGFIYR 504
H T G +Y+SGG + L+ +DP D+W Q+ P ++ R M + +Y
Sbjct: 481 HAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHC-MCTVGERLY- 538
Query: 505 FDLSGSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAPLRLPGGPTGLQPFRCAALDGAIYC 564
+ G+ + +S Y + QW+P A LR G A + IY
Sbjct: 539 -VIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLR------GQSDVGVAVFENKIYV 591
Query: 565 V 565
V
Sbjct: 592 V 592
Score = 68.6 bits (166), Expect = 2e-11
Identities = 48/182 (26%), Positives = 78/182 (42%), Gaps = 26/182 (14%)
Query: 317 GDADARGDA-AVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGR 375
G +A G+ V C++ EW + ++ E P G V ++++GG+
Sbjct: 447 GGRNAAGELPTVECYNPRTNEWTYVAKMSE--PHYGHAGTVYGGVMYISGGIT------H 498
Query: 376 ARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGG---------ECLLSVE 426
++ C++P TD W P+ R + + LY +GG + +LS E
Sbjct: 499 DTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCE 558
Query: 427 RYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGGSLFYR------LLKYDPRRDEW 480
Y P D+W P+A + RG V +IYV GG + + KYDP +DEW
Sbjct: 559 YYSPILDQWTPIAAMLRGQSDVG--VAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEW 616
Query: 481 QE 482
+
Sbjct: 617 HK 618
Score = 44.3 bits (103), Expect = 3e-04
Identities = 27/97 (27%), Positives = 45/97 (46%), Gaps = 11/97 (11%)
Query: 354 LCVLYNYLFVAGGVAPAGPDGRARPSDQVFC--YNPATDSWSAVRPLRQARSQLRLLALD 411
+C + L+V GG G D + C Y+P D W+ + + + +S + + +
Sbjct: 530 MCTVGERLYVIGGNHFRGTSDY---DDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFE 586
Query: 412 GHLYAVGG-----ECLLS-VERYDPRADRWAPVAPLP 442
+Y VGG C++ V++YDP D W V LP
Sbjct: 587 NKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLP 623
Score = 40.8 bits (94), Expect = 0.004
Identities = 30/115 (26%), Positives = 48/115 (41%), Gaps = 15/115 (13%)
Query: 379 SDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGE---------CLLSVERYD 429
S ++ Y+ W ++ P+ R Q + + LY VGG+ + +V R+D
Sbjct: 356 SKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFD 415
Query: 430 PRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGGSLFYRLLK----YDPRRDEW 480
PR ++W VA L + G +Y GG L Y+PR +EW
Sbjct: 416 PRYNKWMQVASL--NEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEW 468
Score = 37.0 bits (84), Expect = 0.054
Identities = 28/121 (23%), Positives = 57/121 (47%), Gaps = 8/121 (6%)
Query: 154 HKAVLAARSDYFRARASRDV-------LRVQGVSLTALRLLLADAYSGRMAGVRPDNVAE 206
H+ ++A+ SDYF+A + + +++ GVS LR ++ Y+ +++ + DN+ +
Sbjct: 108 HRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLS-LNMDNLQD 166
Query: 207 VVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRDAAYCFMSDHYLEV 266
+ A LQ+ + ++L NC EV A L E+ F+ ++ +
Sbjct: 167 TLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPAL 226
Query: 267 L 267
L
Sbjct: 227 L 227
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 87.8 bits (216), Expect = 3e-17
Identities = 142/558 (25%), Positives = 201/558 (36%), Gaps = 125/558 (22%)
Query: 93 SPEERACPEEPAAPSPEPRVWLEDPASPE----EPGEPAPVPPGFGAV------------ 136
SPE + P AP P P P +PE P + P P GAV
Sbjct: 14 SPEHGSPGPGPEAPPPPP----PQPPAPEAERTRPRQARPAAPMEGAVQLLSREGHSVAH 69
Query: 137 -----YGEP--------------DLVLEVSGRRLRAHKAVLAARSDYFRARASRDVLRVQ 177
Y + D+VL V+ + +RAHK VLA+ S YF A + ++ +
Sbjct: 70 NSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESR 129
Query: 178 GVSLT-------ALRLLLADAYSGRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQ 230
+T AL L+ AY+ + V NV ++ A LQL G + Q
Sbjct: 130 QTHVTLHDIDPQALDQLVQFAYTAEIV-VGEGNVQTLLPAASLLQLNGVRDACCKFLLSQ 188
Query: 231 LSLANCY------------EVLSAAKRQRLNELRDAAYC-------------FMSDHYLE 265
L +NC ++L AA R L D A +S L
Sbjct: 189 LDPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLN 248
Query: 266 VLREPAVFGR-LSGAERDLLLRRR-----LRAGRAHLLAAALGPAGERAGSRPQSPSGDA 319
V E V+ LS + D+ RR+ ++ R LL+ A S +
Sbjct: 249 VPSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCK 308
Query: 320 DARGDAAVYCF----HAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGR 375
D +A + G R R EGA LF GG + G
Sbjct: 309 DLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGP----------VLFAVGGGSLFAIHGD 358
Query: 376 ARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGG----ECLLSVERYDPR 431
Y+ TD W V + R+++ + A+ LYAVGG L +VE YDP
Sbjct: 359 CE------AYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPV 412
Query: 432 ADRWAPVAPL--PRGAFAVAHEATTCHGEIYVSGG----SLFYRLLKYDPRRDEWQECPC 485
+ W P + R VA HG +Y +GG S +YDP W
Sbjct: 413 TNTWQPEVSMGTRRSCLGVA----ALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAA 468
Query: 486 SSSRERSADMVALDGFIYRFDLSGSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAPLRLPG 545
S+R R + LDG +Y + G + A +V +Y WSP VA +
Sbjct: 469 MSTRRRYVRVATLDGNLYA--VGGYDSSSHLA-----TVEKYEPQVNVWSP-VASMLSRR 520
Query: 546 GPTGLQPFRCAALDGAIY 563
G+ A L+GA+Y
Sbjct: 521 SSAGV-----AVLEGALY 533
Score = 83.6 bits (205), Expect = 5e-16
Identities = 73/262 (27%), Positives = 119/262 (45%), Gaps = 39/262 (14%)
Query: 290 RAGRAHLLA------AALGPAGERAGSRPQSPSGDADARGDAAVYCFHAAAGEWRELTRL 343
R R H++A A +G A G+R + G A V + W+ +
Sbjct: 365 RTDRWHVVASMSTRRARVGVAA--VGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSM 422
Query: 344 PEGAPARGC-GLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQAR 402
R C G+ L+ L+ AGG A A Y+P T +W++V + R
Sbjct: 423 ---GTRRSCLGVAALHGLLYSAGGYDGASCLNSAER------YDPLTGTWTSVAAMSTRR 473
Query: 403 SQLRLLALDGHLYAVGG----ECLLSVERYDPRADRWAPVAPL--PRGAFAVAHEATTCH 456
+R+ LDG+LYAVGG L +VE+Y+P+ + W+PVA + R + VA
Sbjct: 474 RYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVA----VLE 529
Query: 457 GEIYVSGG----SLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSGSRG 512
G +YV+GG S + +Y P+ W+ + R + D+VA+DG++Y + G+ G
Sbjct: 530 GALYVAGGNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYA--VGGNDG 587
Query: 513 EAQAAGPSGVSVSRYHCLAKQW 534
+ S S+ +Y+ +W
Sbjct: 588 SS-----SLNSIEKYNPRTNKW 604
Score = 69.7 bits (169), Expect = 8e-12
Identities = 41/123 (33%), Positives = 56/123 (45%), Gaps = 10/123 (8%)
Query: 385 YNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGE----CLLSVERYDPRADRWAPVAP 440
Y P + WS V + RS + L+G LY GG CL SVERY P+A W VAP
Sbjct: 503 YEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAP 562
Query: 441 LPRGAFAVAHEATTCHGEIYVSGG----SLFYRLLKYDPRRDEWQECPCSSSRERSADMV 496
+ H+ G +Y GG S + KY+PR ++W C +R S +
Sbjct: 563 M--NIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVA 620
Query: 497 ALD 499
L+
Sbjct: 621 VLE 623
Score = 48.5 bits (114), Expect = 2e-05
Identities = 52/180 (28%), Positives = 67/180 (37%), Gaps = 28/180 (15%)
Query: 393 SAVRPLRQARSQLRLLALDG-HLYAVGGECLLSVERYDPRADRWAPVAPLP--RGAFAVA 449
S RP R + L A+ G L+A+ G+C E YD R DRW VA + R VA
Sbjct: 330 SRTRPRRCEGAGPVLFAVGGGSLFAIHGDC----EAYDTRTDRWHVVASMSTRRARVGVA 385
Query: 450 HEATTCHGEIYVSGGSLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSG 509
+ G S + YDP + WQ +R + AL G +Y
Sbjct: 386 AVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLY------ 439
Query: 510 SRGEAQAAGPSGV----SVSRYHCLAKQWSPCVAPLRLPGGPTGLQPFRCAALDGAIYCV 565
A G G S RY L W+ A T + R A LDG +Y V
Sbjct: 440 -----SAGGYDGASCLNSAERYDPLTGTWTSVAAM------STRRRYVRVATLDGNLYAV 488
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 85.5 bits (210), Expect = 1e-16
Identities = 69/221 (31%), Positives = 98/221 (44%), Gaps = 22/221 (9%)
Query: 330 FHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPAT 389
++ + G W L L P G CV+ L+ GG PDG S + CYNP T
Sbjct: 345 YNPSDGTWLRLADLQ--VPRSGLAGCVVGGLLYAVGG-RNNSPDGNT-DSSALDCYNPMT 400
Query: 390 DSWSAVRPLRQARSQLRLLALDGHLYAVGGE--CL--LSVERYDPRADRWAPVAPLPRGA 445
+ WS P+ R+++ + +DGH+YAVGG C+ SVERY+P D W VAP+
Sbjct: 401 NQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRR 460
Query: 446 FAVAHEATTCHGEIYVSGGSLFYRLLK----YDPRRDEWQECPCSSSRERSADMVALDGF 501
V + +Y GG L Y P R+EW+ ++ A + L
Sbjct: 461 IGVG--VAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNC 518
Query: 502 IYRFDLSGSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAPLR 542
IY G G+ Q SV RY + W+ VAP++
Sbjct: 519 IYA--AGGYDGQDQLN-----SVERYDVETETWT-FVAPMK 551
Score = 68.2 bits (165), Expect = 2e-11
Identities = 42/129 (32%), Positives = 64/129 (49%), Gaps = 12/129 (9%)
Query: 329 CFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPA 388
C++ EWR +T + G G+CVL+N ++ AGG DG+ + + V Y+
Sbjct: 489 CYYPERNEWRMITAM--NTIRSGAGVCVLHNCIYAAGGY-----DGQDQ-LNSVERYDVE 540
Query: 389 TDSWSAVRPLRQARSQLRLLALDGHLYAVGG----ECLLSVERYDPRADRWAPVAPLPRG 444
T++W+ V P++ RS L + G +Y +GG L SVE YDP D W+ V + G
Sbjct: 541 TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG 600
Query: 445 AFAVAHEAT 453
V T
Sbjct: 601 RSGVGVAVT 609
Score = 65.1 bits (157), Expect = 2e-10
Identities = 89/403 (22%), Positives = 149/403 (36%), Gaps = 76/403 (18%)
Query: 153 AHKAVLAARSDYFRA-------RASRDVLRVQGVSLTALRLLLADAYSGRMAGVRPDNVA 205
AHK VLA+ S F+A +V+ ++G+ + L+ AY+ ++ + V
Sbjct: 95 AHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASIS-MGEKCVL 153
Query: 206 EVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRDAAYCFMSDHYLE 265
V+ GA Q+ + +D + QL +N + + A++ EL A ++ H+ E
Sbjct: 154 HVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGE 213
Query: 266 VLREPAVFG-------------------------------RLSGAERDLLLRRRLRAGRA 294
V ++ F + +R ++ LRA R
Sbjct: 214 VAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRC 273
Query: 295 HLLAAALGPAGERAGSRPQSPSGDADARGDAAVYCFHAAAGEWRELTRLPEGAPARGCGL 354
H L + QS S C + ELT L + C
Sbjct: 274 HSLTPNFLQMQLQKCEILQSDS-----------RCKDYLVKIFEELT-LHKPTQVMPCRA 321
Query: 355 CVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHL 414
+ ++ AGG + + YNP+ +W + L+ RS L + G L
Sbjct: 322 PKVGRLIYTAGGYF-------RQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLL 374
Query: 415 YAVGGE--------CLLSVERYDPRADRWAPVAPL--PRGAFAVAHEATTCHGEIYVSGG 464
YAVGG +++ Y+P ++W+P AP+ PR V G IY GG
Sbjct: 375 YAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVG----VIDGHIYAVGG 430
Query: 465 S----LFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIY 503
S + +Y+P RDEW +R + L+ +Y
Sbjct: 431 SHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLY 473
Score = 65.1 bits (157), Expect = 2e-10
Identities = 63/244 (25%), Positives = 89/244 (36%), Gaps = 58/244 (23%)
Query: 289 LRAGRAHLLAAALGPAGERAGSRPQSPSGDADARGDAAVYCFHAAAGEWRELTRLPEGAP 348
L+ R+ L +G G R SP G+ D+ +A+ C++ +W P P
Sbjct: 358 LQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDS---SALDCYNPMTNQWSPCA--PMSVP 412
Query: 349 ARGCGLCVLYNYLFVAGG----------------------VAP----------------- 369
G+ V+ +++ GG VAP
Sbjct: 413 RNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLL 472
Query: 370 ---AGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGG----ECL 422
G DG R + CY P + W + + RS + L +YA GG + L
Sbjct: 473 YAVGGFDGTNR-LNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQL 531
Query: 423 LSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGGSLFYRLLK----YDPRRD 478
SVERYD + W VAP+ A+ T G IYV GG + L YDP D
Sbjct: 532 NSVERYDVETETWTFVAPMKHRRSALG--ITVHQGRIYVLGGYDGHTFLDSVECYDPDTD 589
Query: 479 EWQE 482
W E
Sbjct: 590 TWSE 593
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 85.5 bits (210), Expect = 1e-16
Identities = 69/221 (31%), Positives = 98/221 (44%), Gaps = 22/221 (9%)
Query: 330 FHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPAT 389
++ + G W L L P G CV+ L+ GG PDG S + CYNP T
Sbjct: 345 YNPSDGTWLRLADLQ--VPRSGLAGCVVGGLLYAVGG-RNNSPDGNT-DSSALDCYNPMT 400
Query: 390 DSWSAVRPLRQARSQLRLLALDGHLYAVGGE--CL--LSVERYDPRADRWAPVAPLPRGA 445
+ WS P+ R+++ + +DGH+YAVGG C+ SVERY+P D W VAP+
Sbjct: 401 NQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRR 460
Query: 446 FAVAHEATTCHGEIYVSGGSLFYRLLK----YDPRRDEWQECPCSSSRERSADMVALDGF 501
V + +Y GG L Y P R+EW+ ++ A + L
Sbjct: 461 IGVG--VAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNC 518
Query: 502 IYRFDLSGSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAPLR 542
IY G G+ Q SV RY + W+ VAP++
Sbjct: 519 IYA--AGGYDGQDQLN-----SVERYDVETETWT-FVAPMK 551
Score = 68.2 bits (165), Expect = 2e-11
Identities = 42/129 (32%), Positives = 64/129 (49%), Gaps = 12/129 (9%)
Query: 329 CFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPA 388
C++ EWR +T + G G+CVL+N ++ AGG DG+ + + V Y+
Sbjct: 489 CYYPERNEWRMITAM--NTIRSGAGVCVLHNCIYAAGGY-----DGQDQ-LNSVERYDVE 540
Query: 389 TDSWSAVRPLRQARSQLRLLALDGHLYAVGG----ECLLSVERYDPRADRWAPVAPLPRG 444
T++W+ V P++ RS L + G +Y +GG L SVE YDP D W+ V + G
Sbjct: 541 TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG 600
Query: 445 AFAVAHEAT 453
V T
Sbjct: 601 RSGVGVAVT 609
Score = 65.1 bits (157), Expect = 2e-10
Identities = 89/403 (22%), Positives = 149/403 (36%), Gaps = 76/403 (18%)
Query: 153 AHKAVLAARSDYFRA-------RASRDVLRVQGVSLTALRLLLADAYSGRMAGVRPDNVA 205
AHK VLA+ S F+A +V+ ++G+ + L+ AY+ ++ + V
Sbjct: 95 AHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASIS-MGEKCVL 153
Query: 206 EVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRDAAYCFMSDHYLE 265
V+ GA Q+ + +D + QL +N + + A++ EL A ++ H+ E
Sbjct: 154 HVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGE 213
Query: 266 VLREPAVFG-------------------------------RLSGAERDLLLRRRLRAGRA 294
V ++ F + +R ++ LRA R
Sbjct: 214 VAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRC 273
Query: 295 HLLAAALGPAGERAGSRPQSPSGDADARGDAAVYCFHAAAGEWRELTRLPEGAPARGCGL 354
H L + QS S C + ELT L + C
Sbjct: 274 HSLTPNFLQMQLQKCEILQSDS-----------RCKDYLVKIFEELT-LHKPTQVMPCRA 321
Query: 355 CVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHL 414
+ ++ AGG + + YNP+ +W + L+ RS L + G L
Sbjct: 322 PKVGRLIYTAGGYF-------RQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLL 374
Query: 415 YAVGGE--------CLLSVERYDPRADRWAPVAPL--PRGAFAVAHEATTCHGEIYVSGG 464
YAVGG +++ Y+P ++W+P AP+ PR V G IY GG
Sbjct: 375 YAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVG----VIDGHIYAVGG 430
Query: 465 S----LFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIY 503
S + +Y+P RDEW +R + L+ +Y
Sbjct: 431 SHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLY 473
Score = 65.1 bits (157), Expect = 2e-10
Identities = 63/244 (25%), Positives = 89/244 (36%), Gaps = 58/244 (23%)
Query: 289 LRAGRAHLLAAALGPAGERAGSRPQSPSGDADARGDAAVYCFHAAAGEWRELTRLPEGAP 348
L+ R+ L +G G R SP G+ D+ +A+ C++ +W P P
Sbjct: 358 LQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDS---SALDCYNPMTNQWSPCA--PMSVP 412
Query: 349 ARGCGLCVLYNYLFVAGG----------------------VAP----------------- 369
G+ V+ +++ GG VAP
Sbjct: 413 RNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLL 472
Query: 370 ---AGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGG----ECL 422
G DG R + CY P + W + + RS + L +YA GG + L
Sbjct: 473 YAVGGFDGTNR-LNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQL 531
Query: 423 LSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGGSLFYRLLK----YDPRRD 478
SVERYD + W VAP+ A+ T G IYV GG + L YDP D
Sbjct: 532 NSVERYDVETETWTFVAPMKHRRSALG--ITVHQGRIYVLGGYDGHTFLDSVECYDPDTD 589
Query: 479 EWQE 482
W E
Sbjct: 590 TWSE 593
>gi|157384932 hypothetical protein LOC390594 [Homo sapiens]
Length = 458
Score = 85.1 bits (209), Expect = 2e-16
Identities = 90/314 (28%), Positives = 125/314 (39%), Gaps = 39/314 (12%)
Query: 146 VSGRRLRAHKAVLAARSDYFRA------RASRDV-LRVQGVSLTALRLLLADAYSGRMAG 198
V G+ +A +A+L +FR R +R +R+ +S R L R A
Sbjct: 13 VGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATLQVLRGDRPAL 72
Query: 199 VRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRDAAYCF 258
D + + V A LQ P A+ + L+ NC + AA L ++ +A F
Sbjct: 73 AAEDELLQAVECAAFLQAPALAR----FLEHNLTSDNCALLCDAAAAFGLRDVFHSAALF 128
Query: 259 MSDHYLEVLREPAVFGRLSGAERDLLLRRRLRAGRAHLLAAALGPAGERAGSRPQSPSGD 318
+ D ER+L L RA++ AAL P+ A S G
Sbjct: 129 ICD-----------------GERELAAELALPEARAYV--AALRPSSYAAVSTHTPAPGF 169
Query: 319 ADARGDAAVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARP 378
+ Y WR L LP A G+ L N L++ GGV A +
Sbjct: 170 LEDASRTLCY-LDEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGASKE----V 224
Query: 379 SDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGEC----LLSVERYDPRADR 434
+ FCY+P +W Q R L DG LYA+GGE + SVERYDP A
Sbjct: 225 VELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGC 284
Query: 435 WAPVAPLPRGAFAV 448
W+ VA LP+ A V
Sbjct: 285 WSFVADLPQPAAGV 298
Score = 35.4 bits (80), Expect = 0.16
Identities = 31/113 (27%), Positives = 39/113 (34%), Gaps = 13/113 (11%)
Query: 429 DPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGG------SLFYRLLKYDPRRDEWQE 482
D D W +A LP A + T ++Y+ GG + YDP W E
Sbjct: 181 DEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGASKEVVELGFCYDPDGGTWHE 240
Query: 483 CPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAAGPSGVSVSRYHCLAKQWS 535
P + DG +Y GE Q S SV RY A WS
Sbjct: 241 FPSPHQPRYDTALAGFDGRLYAIG-----GEFQRTPIS--SVERYDPAAGCWS 286
>gi|23397572 kelch-like 34 [Homo sapiens]
Length = 644
Score = 84.0 bits (206), Expect = 4e-16
Identities = 65/201 (32%), Positives = 83/201 (41%), Gaps = 27/201 (13%)
Query: 327 VYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSD------ 380
V F WR LT+LP P G +C N+LFV GG +P+G D
Sbjct: 336 VVAFDVYNHRWRSLTQLP--TPLLGHSVCTAGNFLFVLGGESPSGSASSPLADDSRVVTA 393
Query: 381 QVFCYNPATDSWSAVRPLRQARSQL-------RLLALDGHLYAVGGECLLSVERYDPRAD 433
QV Y+P +W+ V +R+AR+ RLLA+ G GGE L SVE YD R D
Sbjct: 394 QVHRYDPRFHAWTEVPAMREARAHFWCGAVGERLLAVGG--LGAGGEVLASVEMYDLRRD 451
Query: 434 RWAPVAPLPRGAFAVAHEATTCHGEIYVSGG---------SLFYRLLKYDPRRDEWQECP 484
RW LPR A A G +Y+SGG S L P W +
Sbjct: 452 RWTAAGALPRALHGHA-GAVGDRGVVYISGGKAGRGEGGASSLRDLYVLGPEEQVWSKKA 510
Query: 485 CSSSRERSADMVALDGFIYRF 505
+ M L G ++ F
Sbjct: 511 PMGTARFGHHMAVLRGAVFAF 531
Score = 54.7 bits (130), Expect = 3e-07
Identities = 57/216 (26%), Positives = 82/216 (37%), Gaps = 36/216 (16%)
Query: 289 LRAGRAHLLAAALGPAGERAGSRPQSPSGDADARGD--AAVYCFHAAAGEWRELTRLPEG 346
+R RAH A+G ER + G A G+ A+V + W LP
Sbjct: 411 MREARAHFWCGAVG---ERLLA-----VGGLGAGGEVLASVEMYDLRRDRWTAAGALPRA 462
Query: 347 APARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLR 406
G ++++GG A G G + D ++ P WS P+ AR
Sbjct: 463 LHGHA-GAVGDRGVVYISGGKAGRGEGGASSLRD-LYVLGPEEQVWSKKAPMGTARFGHH 520
Query: 407 LLALDGHLYAVGG--ECLLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGG 464
+ L G ++A G E +ERYDP AD+W + PLP F C+G V
Sbjct: 521 MAVLRGAVFAFLGRYEPFSEIERYDPGADQWTRLRPLPYDRF--------CYGLAVVEET 572
Query: 465 SLFYRLLK--------------YDPRRDEWQECPCS 486
+L LK YD D W++ C+
Sbjct: 573 ALLLGGLKWRDSRQVPTRNVVGYDLDLDRWEDIGCA 608
Score = 45.4 bits (106), Expect = 2e-04
Identities = 40/138 (28%), Positives = 60/138 (43%), Gaps = 8/138 (5%)
Query: 141 DLVLEVSGRRLRAHKAVLAARSDYFRA-------RASRDVLRVQGVSLTALRLLLADAYS 193
D+ LE G AH+++LA SDYFRA + V+ + S L+ LL Y+
Sbjct: 30 DVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYT 89
Query: 194 GRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRD 253
++ + D V + + A LQ+ A + QL+ NC + A R L D
Sbjct: 90 AWLS-LSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENCCFAANVAARFGLAHTLD 148
Query: 254 AAYCFMSDHYLEVLREPA 271
AA + H E+L A
Sbjct: 149 AAERCIVSHLQELLARGA 166
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 81.6 bits (200), Expect = 2e-15
Identities = 64/211 (30%), Positives = 95/211 (45%), Gaps = 28/211 (13%)
Query: 353 GLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDG 412
G+ V+ + LFV GG DG + + V CYNP T +W+ + P+ R L + L+G
Sbjct: 500 GVAVIDDKLFVIGG-----RDG-LKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEG 553
Query: 413 HLYAVGG----ECLLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGG---- 464
+YAVGG L +VER+DP++ +W VA + V +G++Y GG
Sbjct: 554 PIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVG--VAALNGKLYSVGGRDGS 611
Query: 465 SLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAAGPSGVS- 523
S + YDP ++W C R + DGF+Y + G A + S
Sbjct: 612 SCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLY------AVGGHDAPASNHCSR 665
Query: 524 ----VSRYHCLAKQWSPCVAPLRLPGGPTGL 550
V RY W+ VAPL +P G+
Sbjct: 666 LLDYVERYDPKTDTWT-MVAPLSMPRDAVGV 695
Score = 60.8 bits (146), Expect = 4e-09
Identities = 40/135 (29%), Positives = 72/135 (53%), Gaps = 8/135 (5%)
Query: 141 DLVLEVSGRRLRAHKAVLAARSDYFRARASRDV-------LRVQGVSLTALRLLLADAYS 193
D++L V R++ AH+ VL++ SDYF A + DV ++++G+ AL L+ AY+
Sbjct: 213 DVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYT 272
Query: 194 GRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRD 253
G + ++ D + ++A A LQLP + + L +NC + + A Q EL
Sbjct: 273 GCLE-LKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMK 331
Query: 254 AAYCFMSDHYLEVLR 268
A+ + ++ +EV+R
Sbjct: 332 VAHSYTMENIMEVIR 346
Score = 57.0 bits (136), Expect = 5e-08
Identities = 33/98 (33%), Positives = 48/98 (48%), Gaps = 4/98 (4%)
Query: 351 GCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLAL 410
G G+ +L+ GG + +R D V Y+P TD+W+ V PL R + + L
Sbjct: 639 GVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLL 698
Query: 411 DGHLYAVGG----ECLLSVERYDPRADRWAPVAPLPRG 444
LYAVGG L ++E YDP+ + W +A L G
Sbjct: 699 GDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASLNIG 736
>gi|31542246 kelch-like 36 [Homo sapiens]
Length = 616
Score = 81.6 bits (200), Expect = 2e-15
Identities = 78/245 (31%), Positives = 109/245 (44%), Gaps = 28/245 (11%)
Query: 332 AAAGEWRELTRLPEGAPARGCGLCV--LYNYLFVAGGVAPAGPDGRARPSDQVFCYNPAT 389
A + +W + T LP AR CV L ++F+AGG G A S+ ++ Y+P
Sbjct: 320 AKSEQWVKETPLP----ARRSHHCVAVLGGFIFIAGGSFSRDNGGDAA-SNLLYRYDPRC 374
Query: 390 DSWSAVRPLRQARSQLRLLALDGHLYAVGGE----CLLSVERYDPRADRWAPVAPLPRGA 445
W V + Q R L +++ L A+GG L SVE Y P+ D W+ VA LPR
Sbjct: 375 KQWIKVASMNQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPR-- 432
Query: 446 FAVAHEATTCHGEIYVSGGSLF----YR--LLKYDPRRDEWQECPCSSSRERSADMVALD 499
F H T +Y+SGG + YR LL YD R D W+E ++ M +L
Sbjct: 433 FTYGHAGTIYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLG 492
Query: 500 GFIYRFDLSGSRGEAQAAGPSGV-SVSRYHCLAKQWSPCVAPLRLPGGPTGLQPFRCAAL 558
IY + GS ++ V V Y QW+ VAPL +G+ A
Sbjct: 493 DSIY--SIGGSDDNIESMERFDVLGVEAYSPQCNQWTR-VAPLLHANSESGV-----AVW 544
Query: 559 DGAIY 563
+G IY
Sbjct: 545 EGRIY 549
Score = 50.8 bits (120), Expect = 4e-06
Identities = 33/115 (28%), Positives = 51/115 (44%), Gaps = 18/115 (15%)
Query: 382 VFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGE----------CLLSVERYDPR 431
+ CY+ TD W RP+ AR + +L +Y++GG +L VE Y P+
Sbjct: 463 LLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSDDNIESMERFDVLGVEAYSPQ 522
Query: 432 ADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGG-----SLFYRLLK-YDPRRDEW 480
++W VAPL G IY+ GG + F + ++ YD D+W
Sbjct: 523 CNQWTRVAPLLHANSESG--VAVWEGRIYILGGYSWENTAFSKTVQVYDREADKW 575
Score = 40.4 bits (93), Expect = 0.005
Identities = 21/68 (30%), Positives = 34/68 (50%), Gaps = 6/68 (8%)
Query: 382 VFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGECL------LSVERYDPRADRW 435
V Y+P + W+ V PL A S+ + +G +Y +GG +V+ YD AD+W
Sbjct: 516 VEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWENTAFSKTVQVYDREADKW 575
Query: 436 APVAPLPR 443
+ LP+
Sbjct: 576 SRGVDLPK 583
>gi|158508542 kelch-like 33 [Homo sapiens]
Length = 453
Score = 80.9 bits (198), Expect = 3e-15
Identities = 68/219 (31%), Positives = 95/219 (43%), Gaps = 23/219 (10%)
Query: 336 EWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAV 395
EW +L LP R + + L+V GG + + P+ + W +
Sbjct: 169 EWGQLPALPAPGRFRHGAASLAGSELYVCGG---QDFYSHSNTLASTLRWEPSQEDWEEM 225
Query: 396 RPLRQARSQLRLLALDGHLYAVGGE----CLLSVERYDPRADRWAPVAPLPRGAFAVAHE 451
PL QARS L+ALDG LYA+GG L SVE Y+P + W P LP F AH
Sbjct: 226 APLSQARSLFSLVALDGKLYALGGRHNDVALDSVETYNPELNVWRPAPALPAPCF--AHA 283
Query: 452 ATTCHGEIYVSG-----GSLFYRLLKYDPRRDEWQECPCSSSRERSAD-MVALDGFIYRF 505
A G++YVSG G L+ YDP+ ++ R+ M AL G +Y
Sbjct: 284 AAILEGQLYVSGGCGGTGQYLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLY-- 341
Query: 506 DLSGSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAPLRLP 544
++G GE + +S Y W+ +APL P
Sbjct: 342 -VAGGLGETEDL----LSFEAYELRTDSWTH-LAPLPSP 374
Score = 38.9 bits (89), Expect = 0.014
Identities = 30/106 (28%), Positives = 39/106 (36%), Gaps = 12/106 (11%)
Query: 344 PEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARS 403
P G P G + L L+VAGG+ G Y TDSW+ + PL
Sbjct: 323 PMGVPRAGHVMAALGGRLYVAGGL------GETEDLLSFEAYELRTDSWTHLAPLPSPHV 376
Query: 404 QLRLLALDGHLYAVGGECLLS------VERYDPRADRWAPVAPLPR 443
L G L +GG + + Y P RW + LPR
Sbjct: 377 GAASAVLQGELLVLGGYSHRTYALSHLIHAYCPGLGRWLCLGTLPR 422
>gi|8922854 kelch-like 26 [Homo sapiens]
Length = 615
Score = 80.9 bits (198), Expect = 3e-15
Identities = 82/270 (30%), Positives = 117/270 (43%), Gaps = 27/270 (10%)
Query: 314 SPSGDADARGDAAVYCF-HAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGP 372
+P D+D + VY A +RELT + G + C + VL N+++VAGG
Sbjct: 317 TPYTDSDRSVSSKVYQLPEPGARHFRELTEMEVGC-SHTC-VAVLDNFVYVAGGQHLQYR 374
Query: 373 DGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGE----CLLSVERY 428
G D + Y+P + W ++ ++++R Q +L L G +YA GG L SVERY
Sbjct: 375 SGEGAV-DACYRYDPHLNRWLRLQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERY 433
Query: 429 DPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGGSLF-----YRLLKYDPRRDEWQ-E 482
PR + W L R + H G +Y+SGG L YDP D+W+ +
Sbjct: 434 CPRRNEWGYACSLKRRTW--GHAGAASGGRLYISGGYGISVEDKKALHCYDPVADQWEFK 491
Query: 483 CPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAPLR 542
P S R A MV G IY G R + ++V Y QW+ V+P+R
Sbjct: 492 APMSEPRVLHA-MVGAGGRIYAL---GGRMDHVDRCFDVLAVEYYVPETDQWT-SVSPMR 546
Query: 543 LPGGPTGLQPFRCAALDGAIYCVSRAGTWR 572
G C L+ IY V WR
Sbjct: 547 AGQSEAG-----CCLLERKIYIVG-GYNWR 570
Score = 64.7 bits (156), Expect = 2e-10
Identities = 44/136 (32%), Positives = 69/136 (50%), Gaps = 8/136 (5%)
Query: 141 DLVLEVSGRRLRAHKAVLAARSDYFRA-------RASRDVLRVQGVSLTALRLLLADAYS 193
D+VL ++ AHK VLAA SDYFRA AS+DV+ ++GVS LR ++ AYS
Sbjct: 64 DVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREASQDVIELKGVSARGLRHIIDFAYS 123
Query: 194 GRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRD 253
+ + D V +V+ A LQ+ + + + +S+ C + A L LR+
Sbjct: 124 AEVT-LDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMSVETCLNIGQMATTFSLASLRE 182
Query: 254 AAYCFMSDHYLEVLRE 269
+ F H+L++ E
Sbjct: 183 SVDAFTFRHFLQIAEE 198
Score = 41.2 bits (95), Expect = 0.003
Identities = 41/161 (25%), Positives = 62/161 (38%), Gaps = 23/161 (14%)
Query: 302 GPAGERAGSRPQSPSGDADARGDA-AVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNY 360
G AG +G R G + D A++C+ A +W + P P VL+
Sbjct: 452 GHAGAASGGRLYISGGYGISVEDKKALHCYDPVADQWE--FKAPMSEPR------VLHAM 503
Query: 361 LFVAGGVAPAGPDGRARPSDQVF------CYNPATDSWSAVRPLRQARSQLRLLALDGHL 414
+ G + G GR D+ F Y P TD W++V P+R +S+ L+ +
Sbjct: 504 VGAGGRIYALG--GRMDHVDRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLERKI 561
Query: 415 YAVGG------ECLLSVERYDPRADRWAPVAPLPRGAFAVA 449
Y VGG V+ Y+ D W P +A
Sbjct: 562 YIVGGYNWRLNNVTGIVQVYNTDTDEWERDLHFPESFAGIA 602
>gi|24432026 kelch-like [Homo sapiens]
Length = 634
Score = 80.1 bits (196), Expect = 6e-15
Identities = 73/241 (30%), Positives = 105/241 (43%), Gaps = 31/241 (12%)
Query: 335 GEWRELTRLPEGAPARGC-GLCVLYNYLFVAGGVAPAGPDGRA---RPSDQVFCYNPATD 390
GEW+ T AP G+ VL N++++ GG D R + + Y+P +
Sbjct: 326 GEWKHFTA--SLAPRMSNQGIAVLNNFVYLIGG------DNNVQGFRAESRCWRYDPRHN 377
Query: 391 SWSAVRPLRQARSQLRLLALDGHLYAVGGEC----LLSVERYDPRADRWAPVAPLPRGAF 446
W ++ L+Q + L + + ++YAV G L +VERYDP + WA VAPL R +
Sbjct: 378 RWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKREVY 437
Query: 447 AVAHEATTCHGEIYVSGGSLFYRLLK----YDPRRDEWQECPCSSSRERSADMVALDGFI 502
AH T G++Y++ G LK YDP + W R M L +
Sbjct: 438 --AHAGATLEGKMYITCGRRGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMATLLNKL 495
Query: 503 YRFDLSGSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAPLRLPGGPTGLQPFRCAALDGAI 562
Y + GS +A V+ Y C + QWS V PL G G+ A LD I
Sbjct: 496 Y--VIGGSNNDA-GYRRDVHQVACYSCTSGQWS-SVCPLPAGHGEPGI-----AVLDNRI 546
Query: 563 Y 563
Y
Sbjct: 547 Y 547
Score = 46.6 bits (109), Expect = 7e-05
Identities = 35/135 (25%), Positives = 62/135 (45%), Gaps = 8/135 (5%)
Query: 141 DLVLEVSGRRLRAHKAVLAARSDYFRA-------RASRDVLRVQGVSLTALRLLLADAYS 193
D+VL V GR + AH+ +LAA DYFR ++ + + GVS A+ +L Y+
Sbjct: 51 DVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYT 110
Query: 194 GRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRD 253
+ + NV E + A +LQ+P D + + N +V A+ L+ L +
Sbjct: 111 SELE-LSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENILDVYRLAELFDLSRLTE 169
Query: 254 AAYCFMSDHYLEVLR 268
++ +++ R
Sbjct: 170 QLDTYILKNFVAFSR 184
Score = 45.4 bits (106), Expect = 2e-04
Identities = 33/116 (28%), Positives = 45/116 (38%), Gaps = 14/116 (12%)
Query: 328 YCFHAAAGEWRELTRLPEGAPARGC--GLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCY 385
+C+ + W L P R G+ L N L+V GG G R QV CY
Sbjct: 464 HCYDPGSNTWHTLA----DGPVRRAWHGMATLLNKLYVIGG--SNNDAGYRRDVHQVACY 517
Query: 386 NPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGECLLSVER------YDPRADRW 435
+ + WS+V PL + + LD +Y +GG R YD D W
Sbjct: 518 SCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRTGYVHIYDVEKDCW 573
Score = 32.3 bits (72), Expect = 1.3
Identities = 23/78 (29%), Positives = 34/78 (43%), Gaps = 7/78 (8%)
Query: 316 SGDADARGDA-AVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDG 374
+ DA R D V C+ +G+W + LP G G+ VL N ++V GG +
Sbjct: 502 NNDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEP--GIAVLDNRIYVLGGRS----HN 555
Query: 375 RARPSDQVFCYNPATDSW 392
R + V Y+ D W
Sbjct: 556 RGSRTGYVHIYDVEKDCW 573
>gi|156616301 kelch-like 32 [Homo sapiens]
Length = 620
Score = 79.7 bits (195), Expect = 7e-15
Identities = 70/254 (27%), Positives = 108/254 (42%), Gaps = 22/254 (8%)
Query: 332 AAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDS 391
AA W EL +P G + C + V+ ++LFVAGG GR Y+P ++S
Sbjct: 321 AAIANWSELAPMPVGR-SHHC-VAVMGDFLFVAGGEVEHA-SGRTCAVRTACRYDPRSNS 377
Query: 392 WSAVRPLRQARSQLRLLALDGHLYAVGG-----ECLLSVERYDPRADRWAPVAPLPRGAF 446
W+ + P++ R L A++ +LYAVGG + L +VERY P+ ++W V R
Sbjct: 378 WAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRS-- 435
Query: 447 AVAHEATTCHGEIYVSGG-----SLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGF 501
H G +++SGG RL+ Y+P +++W R M A+
Sbjct: 436 LSCHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRK 495
Query: 502 IYRFDLSGSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAPLRLPGGPTGLQPFRCAALDGA 561
+Y L G+ + + Y+ QW+ C L TG A +G
Sbjct: 496 LY--VLGGNDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLL-----TGQNESGVAVHNGR 548
Query: 562 IYCVSRAGTWRFQP 575
IY V W +P
Sbjct: 549 IYLVGGYSIWTNEP 562
Score = 53.1 bits (126), Expect = 7e-07
Identities = 40/135 (29%), Positives = 64/135 (47%), Gaps = 8/135 (5%)
Query: 141 DLVLEVSGRRLRAHKAVLAARSDYFRA-------RASRDVLRVQGVSLTALRLLLADAYS 193
D+ L ++ AHKAVLAA SDYFRA + D + + GV+ L+ L AY+
Sbjct: 43 DITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVESGADEVNLHGVTSLGLKQALEFAYT 102
Query: 194 GRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRD 253
G++ + P + +V+A LQL + + +L+ N ++ A L L
Sbjct: 103 GQIL-LEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNYLDLYRLADLFNLTLLEK 161
Query: 254 AAYCFMSDHYLEVLR 268
A F+ H E+L+
Sbjct: 162 AVIDFLVKHLSELLK 176
Score = 40.4 bits (93), Expect = 0.005
Identities = 31/119 (26%), Positives = 51/119 (42%), Gaps = 20/119 (16%)
Query: 378 PSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGE---------CLLSVERY 428
P DQ A +WS + P+ RS + + L+ GGE + + RY
Sbjct: 312 PVDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRY 371
Query: 429 DPRADRWAPVAPLP--RGAFAVAHEATTCHGEIYVSGGSLFYRLL-----KYDPRRDEW 480
DPR++ WA +AP+ R F + +Y GG R + +Y P++++W
Sbjct: 372 DPRSNSWAEIAPMKNCREHFVLG----AMEEYLYAVGGRNELRQVLPTVERYCPKKNKW 426
>gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo
sapiens]
Length = 634
Score = 79.0 bits (193), Expect = 1e-14
Identities = 73/248 (29%), Positives = 106/248 (42%), Gaps = 32/248 (12%)
Query: 337 WRELTRLPEGAPARGCGLCV--LYNYLFVAGGVAPAGPDGRARPSDQVFC-YNPATDSWS 393
W +LT +P A+ CV + +L+VAGG +A+ + FC Y+P ++W
Sbjct: 345 WSKLTEMP----AKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNTWI 400
Query: 394 AVRPLRQARSQLRLLALDGHLYAVGGE----CLLSVERYDPRADRWAPVAPLPRGAFAVA 449
+ + Q R+ L +G +YA GG L S+E Y P ++W P PL
Sbjct: 401 HLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKTPLE--VARCC 458
Query: 450 HEATTCHGEIYVSGG----SLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRF 505
H + G + V+GG + + YDP D WQE P S+ V L +Y
Sbjct: 459 HASAVADGRVLVTGGYIANAYSRSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVM 518
Query: 506 DLS--GSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAPLRLPGGPTGLQPFRCAALDGAIY 563
S G RGE ++V Y QWS APL++ G+ +AL G Y
Sbjct: 519 GGSQLGPRGERVDV----LTVECYSPATGQWS-YAAPLQV-----GVSTAGVSALHGRAY 568
Query: 564 CVSRAGTW 571
V G W
Sbjct: 569 LV---GGW 573
Score = 52.4 bits (124), Expect = 1e-06
Identities = 51/185 (27%), Positives = 78/185 (42%), Gaps = 30/185 (16%)
Query: 316 SGDADARGD-AAVYCFHAAAGEWRELTRLPEGAPARGC-GLCVLYNYLFVAGG-VAPAGP 372
+G +A G A++ C+ + +W+ T L AR C V + V GG +A A
Sbjct: 424 AGGRNAEGSLASLECYVPSTNQWQPKTPLEV---ARCCHASAVADGRVLVTGGYIANAY- 479
Query: 373 DGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGECL---------L 423
S V Y+PA+DSW + L R + L +Y +GG L L
Sbjct: 480 ------SRSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGGSQLGPRGERVDVL 533
Query: 424 SVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGG-----SLFYRLLK-YDPRR 477
+VE Y P +W+ APL G + HG Y+ GG + + ++ + P
Sbjct: 534 TVECYSPATGQWSYAAPLQVGVSTAG--VSALHGRAYLVGGWNEGEKKYKKCIQCFSPEL 591
Query: 478 DEWQE 482
+EW E
Sbjct: 592 NEWTE 596
Score = 51.6 bits (122), Expect = 2e-06
Identities = 35/129 (27%), Positives = 68/129 (52%), Gaps = 5/129 (3%)
Query: 141 DLVLEVSGRRLRAHKAVLAARSDYFRARASRD--VLRVQ--GVSLTALRLLLADAYSGRM 196
DLV+ + HK+V+A+ S+YF +D + RV +S L ++A AY+G++
Sbjct: 74 DLVIGTKTKSFDVHKSVMASCSEYFYNILKKDPSIQRVDLNDISPLGLATVIAYAYTGKL 133
Query: 197 AGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRDAAY 256
+ + +++ A LQ+ + +D + ++S+ NC V++ A+ L + AA
Sbjct: 134 T-LSLYTIGSIISAAVYLQIHTLVKMCSDFLIREMSVENCMYVVNIAETYSLKNAKAAAQ 192
Query: 257 CFMSDHYLE 265
F+ D++LE
Sbjct: 193 KFIRDNFLE 201
Score = 50.8 bits (120), Expect = 4e-06
Identities = 39/131 (29%), Positives = 57/131 (43%), Gaps = 11/131 (8%)
Query: 326 AVYCFHAAAGEWRELTRLPEGAPARGCGLCV-LYNYLFVAGGVAPAGPDGRARPSDQVFC 384
+V + A+ W+EL L + RG V L + ++V GG + GP G V C
Sbjct: 482 SVCAYDPASDSWQELPNL---STPRGWHCAVTLSDRVYVMGG-SQLGPRGERVDVLTVEC 537
Query: 385 YNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGG------ECLLSVERYDPRADRWAPV 438
Y+PAT WS PL+ S + AL G Y VGG + ++ + P + W
Sbjct: 538 YSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKKCIQCFSPELNEWTED 597
Query: 439 APLPRGAFAVA 449
LP V+
Sbjct: 598 DELPEATVGVS 608
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 79.0 bits (193), Expect = 1e-14
Identities = 57/184 (30%), Positives = 85/184 (46%), Gaps = 21/184 (11%)
Query: 329 CFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPA 388
C+ GEW+ L +LPE + +C L N + V+GG R D V+ YN
Sbjct: 334 CYDPVTGEWKSLAKLPEFTKSE-YAVCALRNDILVSGG--------RINSRD-VWIYNSQ 383
Query: 389 TDSWSAVRPLRQARSQLRLLALDGHLYAVGG----ECLLSVERYDPRADRWAPVAPLPRG 444
+ W V L + R + ++ L G +Y VGG L SVE YD ++RW VAPL
Sbjct: 384 LNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEA 443
Query: 445 AFAVAHEATTCHGEIYVSGG-----SLFYRLLKYDPRRDEWQECPCSSSRERSADMVALD 499
+ A T+C G+++V GG + ++ YDP + W +R V+L+
Sbjct: 444 VSSPA--VTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLN 501
Query: 500 GFIY 503
IY
Sbjct: 502 NLIY 505
Score = 57.0 bits (136), Expect = 5e-08
Identities = 42/142 (29%), Positives = 67/142 (47%), Gaps = 14/142 (9%)
Query: 325 AAVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFC 384
++V C+ + + W E+ L E + CV LFV GG GPD SD+V
Sbjct: 422 SSVECYDSFSNRWTEVAPLKEAVSSPAVTSCV--GKLFVIGG----GPDDNT-CSDKVQS 474
Query: 385 YNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGECLLSVERYDPRADRWAPVAPLPRG 444
Y+P T+SW + A+ + ++L+ +Y GG ++ YDP D W V +
Sbjct: 475 YDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGG-LTKAIYCYDPVEDYWMHV----QN 529
Query: 445 AFAVAHEA--TTCHGEIYVSGG 464
F+ + C+G+IY+ GG
Sbjct: 530 TFSRQENCGMSVCNGKIYILGG 551
Score = 52.4 bits (124), Expect = 1e-06
Identities = 86/380 (22%), Positives = 137/380 (36%), Gaps = 48/380 (12%)
Query: 141 DLVLEVSGRRLRAHKAVLAARSDYFRA------RASRDVL-RVQGVSLTALRLLLADAYS 193
D+++ V G+ H+AVL+A S YFRA R SR++L + G+ A+ L Y+
Sbjct: 67 DVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAMECFLQYVYT 126
Query: 194 GRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRD 253
G++ + +NV + + Q+ + QL NC + A L L
Sbjct: 127 GKVK-ITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFT 185
Query: 254 AAYCFMSDHYLEVLREPAVFGRLSGAERDLLLRRRLRAGRAHLLAAALGPAGERAGS--R 311
F + +V + D + L G+ ++ A+ RA R
Sbjct: 186 KCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRR 245
Query: 312 P--------------------QSPSGDADARGDAAVYCFHAAAGEWREL---TRLPEGAP 348
P Q+ D + Y A + L P P
Sbjct: 246 PLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHILGNEMMSPRTRP 305
Query: 349 ARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQ-ARSQLRL 407
R G + V GG G G P + CY+P T W ++ L + +S+ +
Sbjct: 306 RRSTGYS---EVIVVVGGCERVG--GFNLPYTE--CYDPVTGEWKSLAKLPEFTKSEYAV 358
Query: 408 LALDGHLYAVGGEC-LLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGGSL 466
AL + GG V Y+ + + W VA L +G + H+ G++YV GG
Sbjct: 359 CALRNDILVSGGRINSRDVWIYNSQLNIWIRVASLNKGRW--RHKMAVLLGKVYVVGGYD 416
Query: 467 FYRLLK----YDPRRDEWQE 482
L YD + W E
Sbjct: 417 GQNRLSSVECYDSFSNRWTE 436
Score = 33.1 bits (74), Expect = 0.78
Identities = 38/148 (25%), Positives = 62/148 (41%), Gaps = 16/148 (10%)
Query: 399 RQARSQLRLLALDGHLYAVGGECLLSVERYDPRADRWAPVAPLP---RGAFAVAHEATTC 455
R++ ++ + G VGG L E YDP W +A LP + +AV
Sbjct: 306 RRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVC----AL 361
Query: 456 HGEIYVSGGSLFYR-LLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSGSRGEA 514
+I VSGG + R + Y+ + + W + M L G +Y + G G+
Sbjct: 362 RNDILVSGGRINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVY--VVGGYDGQN 419
Query: 515 QAAGPSGVSVSRYHCLAKQWSPCVAPLR 542
+ + SV Y + +W+ VAPL+
Sbjct: 420 RLS-----SVECYDSFSNRWTE-VAPLK 441
Score = 31.2 bits (69), Expect = 3.0
Identities = 16/64 (25%), Positives = 27/64 (42%), Gaps = 7/64 (10%)
Query: 326 AVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCY 385
A+YC+ W + + CG+ V +++ GG G +D + CY
Sbjct: 513 AIYCYDPVEDYWMHVQNT--FSRQENCGMSVCNGKIYILGGRRENG-----EATDTILCY 565
Query: 386 NPAT 389
+PAT
Sbjct: 566 DPAT 569
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 78.2 bits (191), Expect = 2e-14
Identities = 95/434 (21%), Positives = 168/434 (38%), Gaps = 63/434 (14%)
Query: 155 KAVLAARSDYFRARASRDV-------LRVQGVSLTALRLLLADAYSGRMAGVRPDNVAEV 207
+ VL++ SDYF A + DV ++++GV +L L+ AY+GR+ ++ DN+ +
Sbjct: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLE-LKEDNIECL 232
Query: 208 VAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRDAAYCFMSDHYLEVL 267
++ A LQL + + QL +NC + S A Q +L A+ + +H++EV+
Sbjct: 233 LSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVI 292
Query: 268 R--------------------------EPAVFGRLSGAERDLLLRRR-LRAGRAHLLAAA 300
R E + L+ DL RR+ L A++
Sbjct: 293 RNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPL 352
Query: 301 LGPAGERAGSRPQSPSGDADARGDAAVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNY 360
L P D + + + E R + + P P +
Sbjct: 353 LAPQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKS-----TVGT 407
Query: 361 LFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGG- 419
LF GG+ + + + Y+ T+ W+ V + R Q + LD LY VGG
Sbjct: 408 LFAVGGM------DSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGR 461
Query: 420 ---ECLLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGG----SLFYRLLK 472
+ L +VE Y+P+ W+ + P+ + G +Y GG S + +
Sbjct: 462 DGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLG--VAVLEGPMYAVGGHDGWSYLNTVER 519
Query: 473 YDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAAGPSGVSVSRYHCLAK 532
+DP+ +W S+ + + L G +Y + G G + SV +
Sbjct: 520 WDPQARQWNFVATMSTPRSTVGVAVLSGKLYA--VGGRDGSSCLK-----SVECFDPHTN 572
Query: 533 QWSPCVAPLRLPGG 546
+W+ C + GG
Sbjct: 573 KWTLCAQMSKRRGG 586
Score = 77.0 bits (188), Expect = 5e-14
Identities = 55/161 (34%), Positives = 79/161 (49%), Gaps = 20/161 (12%)
Query: 353 GLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDG 412
G+ VL + L+V GG DG + + V CYNP T +WS + P+ R L + L+G
Sbjct: 447 GVAVLDDKLYVVGG-----RDG-LKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEG 500
Query: 413 HLYAVGG----ECLLSVERYDPRADRWAPVAPL--PRGAFAVAHEATTCHGEIYVSGGSL 466
+YAVGG L +VER+DP+A +W VA + PR VA G++Y GG
Sbjct: 501 PMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVA----VLSGKLYAVGGRD 556
Query: 467 FYRLLK----YDPRRDEWQECPCSSSRERSADMVALDGFIY 503
LK +DP ++W C S R + +G +Y
Sbjct: 557 GSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLY 597
Score = 60.5 bits (145), Expect = 5e-09
Identities = 40/123 (32%), Positives = 58/123 (47%), Gaps = 6/123 (4%)
Query: 326 AVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCY 385
+V CF +W ++ + G G+ L+ GG + +R SD V Y
Sbjct: 563 SVECFDPHTNKWTLCAQMSKRRG--GVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERY 620
Query: 386 NPATDSWSAVRPLRQARSQLRLLALDGHLYAVGG----ECLLSVERYDPRADRWAPVAPL 441
+P TD W+AV + +R + + L LYAVGG L +VE YDP+ + W VAPL
Sbjct: 621 DPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPL 680
Query: 442 PRG 444
G
Sbjct: 681 CLG 683
Score = 30.4 bits (67), Expect = 5.1
Identities = 18/51 (35%), Positives = 28/51 (54%), Gaps = 6/51 (11%)
Query: 353 GLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARS 403
G+C+L + L+ GG DG+A + V Y+P T+ W+ V PL R+
Sbjct: 641 GVCLLGDKLYAVGGY-----DGQAY-LNTVEAYDPQTNEWTQVAPLCLGRA 685
>gi|128485503 kelch-like 30 [Homo sapiens]
Length = 560
Score = 78.2 bits (191), Expect = 2e-14
Identities = 110/464 (23%), Positives = 170/464 (36%), Gaps = 60/464 (12%)
Query: 141 DLVLEVSGRRLRAHKAVLAARSDYFRARASRDV-------LRVQGVSLTALRLLLADAYS 193
D+ L V GR L H+ +LA S YF A + D + ++ V + L+ Y+
Sbjct: 16 DVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRDVEPAVVGQLVDFVYT 75
Query: 194 GRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRD 253
GR+ + NV + A RL P + + QL ANC + ++Q L +
Sbjct: 76 GRLT-ITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGICEFGEQQGLLGVAA 134
Query: 254 AAYCFMSDHYLEVLREPAVF-----GRLSGAERDLLLRRRLRAGRAHLLAAALGPAGERA 308
A+ F+ +++ V RE ++ DLL + ++ L+ RA
Sbjct: 135 KAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRLEALMRWVRHDPQARA 194
Query: 309 GSRPQSPS---GDADARGDAAVYCFHAAAGEWRELTRLPEGAPARGCGLCV---LYNYLF 362
P+ S DA R + E R G L + L L
Sbjct: 195 AHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALSQGHDGAPLALQQKLEEVLV 254
Query: 363 VAGGVAPAGPDGRARPS---DQVFCYNPATDSWSAVRPLRQARS-QLRLLALDGHLYAVG 418
V GG A + P+ YN W A+ L AL+ ++Y G
Sbjct: 255 VVGGQALEEEEAGEEPTPGLGNFAFYNSKAKRWMALPDFPDYHKWGFSLAALNNNIYVTG 314
Query: 419 GECLLSVERYDP--------RADRWAPVAPL--PRGAFAVAHEATTCHGEIYVSGGSLF- 467
G + + + W PVAP+ PR H + +GEIYV GG+
Sbjct: 315 GSRGTKTDTWSTTQAWCFPLKEASWKPVAPMLKPR----TNHASAALNGEIYVIGGTTLD 370
Query: 468 -YRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAAGPS-----G 521
+ YDP D W P S + + ++ F +G RG G S
Sbjct: 371 VVEVESYDPYTDSW--TPVSPALK----------YVSNFSAAGCRGRLYLVGSSACKYNA 418
Query: 522 VSVSRYHCLAKQWSPCVAPLRLPGGPTGLQPFRCAALDGAIYCV 565
+++ Y+ + WS +P P L RCAAL G +Y +
Sbjct: 419 LALQCYNPVTDAWSVIASPFL----PKYLSSPRCAALHGELYLI 458
Score = 44.3 bits (103), Expect = 3e-04
Identities = 36/110 (32%), Positives = 46/110 (41%), Gaps = 20/110 (18%)
Query: 384 CYNPATDSWSAVRP--LRQARSQLRLLALDGHLYAVGGECLLSVERYDPRADRWAPVAPL 441
CYNP TD+WS + L + S R AL G LY + G+ V YDP A+ W V
Sbjct: 423 CYNPVTDAWSVIASPFLPKYLSSPRCAALHGELYLI-GDNTKKVYVYDPGANLWQKVQSQ 481
Query: 442 ----PRGAFAVAHEATTCHGEIYVSG-------GSLFYRLLKYDPRRDEW 480
GA +A +YV+G G + YD RD W
Sbjct: 482 HSLHENGALVPLGDA------LYVTGGRWQGMEGDYHVEMEAYDTVRDTW 525
Score = 33.5 bits (75), Expect = 0.60
Identities = 28/127 (22%), Positives = 47/127 (37%), Gaps = 22/127 (17%)
Query: 326 AVYCFHAAAGEWRELTR--LPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVF 383
A+ C++ W + LP+ + C L+ L++ G + +V+
Sbjct: 420 ALQCYNPVTDAWSVIASPFLPKYLSSPRCA--ALHGELYLIGD-----------NTKKVY 466
Query: 384 CYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGG-------ECLLSVERYDPRADRWA 436
Y+P + W V+ L+ L LY GG + + +E YD D W
Sbjct: 467 VYDPGANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHVEMEAYDTVRDTWT 526
Query: 437 PVAPLPR 443
LPR
Sbjct: 527 RHGALPR 533
>gi|55741643 kelch-like 14 [Homo sapiens]
Length = 628
Score = 77.4 bits (189), Expect = 4e-14
Identities = 70/241 (29%), Positives = 105/241 (43%), Gaps = 29/241 (12%)
Query: 337 WRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVR 396
W+ LT +P + A C + + N+LFV GG P+G+ ++ V Y+P +SW +
Sbjct: 352 WKILTIMPYNS-AHHC-VVEVENFLFVLGGEDQWNPNGK-HSTNFVSRYDPRFNSWIQLP 408
Query: 397 PLRQARSQLRLLALDGHLYAVGGE----CLLSVERYDPRADRWAPVAPLPRGAFAVAHEA 452
P+++ R+ LD HLY +GG L SVE Y+ + W V+ LP+ AH
Sbjct: 409 PMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQP--LAAHAG 466
Query: 453 TTCHGEIYVSG----GSLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLS 508
+G+IY+SG G L YDP D W +++ + ++ +Y
Sbjct: 467 AVHNGKIYISGGVHNGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAI--- 523
Query: 509 GSRGEAQAAGPSGVSVSRYHCL---AKQWSPCVAP-LRLPGGPTGLQPFRCAALDGAIYC 564
G G S + V C QW+ P L GP CA LD +IY
Sbjct: 524 ---GGNHLKGFSHLDVMLVECYDPKGDQWNILQTPILEGRSGP------GCAVLDDSIYL 574
Query: 565 V 565
V
Sbjct: 575 V 575
Score = 57.8 bits (138), Expect = 3e-08
Identities = 45/171 (26%), Positives = 77/171 (45%), Gaps = 21/171 (12%)
Query: 325 AAVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFC 384
++V C++ EWR ++ LP+ P V ++++GGV +G P ++C
Sbjct: 439 SSVECYNLETNEWRYVSSLPQ--PLAAHAGAVHNGKIYISGGV----HNGEYVP--WLYC 490
Query: 385 YNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGECL--------LSVERYDPRADRWA 436
Y+P D W+ + + R+ L ++ LYA+GG L + VE YDP+ D+W
Sbjct: 491 YDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLVECYDPKGDQWN 550
Query: 437 PV-APLPRG----AFAVAHEATTCHGEIYVSGGSLFYRLLKYDPRRDEWQE 482
+ P+ G AV ++ G S G+ + Y P + W E
Sbjct: 551 ILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTWTE 601
Score = 30.8 bits (68), Expect = 3.9
Identities = 13/27 (48%), Positives = 18/27 (66%)
Query: 141 DLVLEVSGRRLRAHKAVLAARSDYFRA 167
D+ L G++ HKAVLA+ S YFR+
Sbjct: 34 DVTLTAQGQQFHCHKAVLASCSQYFRS 60
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 75.5 bits (184), Expect = 1e-13
Identities = 63/212 (29%), Positives = 94/212 (44%), Gaps = 26/212 (12%)
Query: 353 GLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDG 412
G+ V+ N L+V GG DG + + V C+NP W+ + P+ R L + L+G
Sbjct: 470 GVAVIDNKLYVVGG-----RDG-LKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEG 523
Query: 413 HLYAVGG----ECLLSVERYDPRADRWAPVAPL--PRGAFAVAHEATTCHGEIYVSGG-- 464
+YAVGG L +VER+DP +W VA + PR V + ++Y GG
Sbjct: 524 PMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGV----VALNNKLYAIGGRD 579
Query: 465 --SLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAAGPSGV 522
S + +DP ++W C S R + +GF+Y + G + S +
Sbjct: 580 GSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLY---VVGGHDAPASNHCSRL 636
Query: 523 S--VSRYHCLAKQWSPCVAPLRLPGGPTGLQP 552
S V RY WS VAPL +P + P
Sbjct: 637 SDCVERYDPKGDSWS-TVAPLSVPRDAVAVCP 667
Score = 67.8 bits (164), Expect = 3e-11
Identities = 105/468 (22%), Positives = 180/468 (38%), Gaps = 71/468 (15%)
Query: 141 DLVLEVSGRRLRAHKAVLAARSDYFRARASRDVL-------RVQGVSLTALRLLLADAYS 193
D++L R+ AH+ VL+A SDYF A + DVL R++GV AL L+ AY+
Sbjct: 183 DVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYT 242
Query: 194 GRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLAN------------CYEVLS 241
G + ++ D + ++A A LQL ++ + QL +N C E+L+
Sbjct: 243 GVLQ-LKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELLN 301
Query: 242 AAKRQRLNEL--------------RDAAYCFMSDHYLEVLREPAVFGRL-SGAERDLLLR 286
A + + + + SD + V E +F L D+ R
Sbjct: 302 VAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDD-INVPDEETIFHALMQWVGHDVQNR 360
Query: 287 RRLRAGRAHLLAAALGPAGERAGSRPQSP-SGDADARGDAAVYCFHAAAGEWRELTRLPE 345
+ + L P A S +GD + + + E R + + P
Sbjct: 361 QGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPR 420
Query: 346 GAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQL 405
P + L+ GG+ + + + Y+ T+SW + + R Q
Sbjct: 421 TKPRKST-----VGALYAVGGM------DAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQF 469
Query: 406 RLLALDGHLYAVGG----ECLLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYV 461
+ +D LY VGG + L +VE ++P W + P+ + T G +Y
Sbjct: 470 GVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLG--VATLEGPMYA 527
Query: 462 SGG----SLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAA 517
GG S + ++DP +W S+ + +VAL+ +Y + G G +
Sbjct: 528 VGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYA--IGGRDGSSCLK 585
Query: 518 GPSGVSVSRYHCLAKQWSPCVAPLRLPGGPTGLQPFRCAALDGAIYCV 565
S+ + +WS C AP+ G G+ A +G +Y V
Sbjct: 586 -----SMEYFDPHTNKWSLC-APMSKRRGGVGV-----ATYNGFLYVV 622
Score = 64.7 bits (156), Expect = 2e-10
Identities = 49/151 (32%), Positives = 70/151 (46%), Gaps = 26/151 (17%)
Query: 348 PARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRL 407
P G+ L N L+ GG DG + + ++P T+ WS P+ + R + +
Sbjct: 559 PRSTVGVVALNNKLYAIGG-----RDGSSCLKSMEY-FDPHTNKWSLCAPMSKRRGGVGV 612
Query: 408 LALDGHLYAVGGECLLS----------VERYDPRADRWAPVAPL--PRGAFAVAHEATTC 455
+G LY VGG + VERYDP+ D W+ VAPL PR A AV
Sbjct: 613 ATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVC----PL 668
Query: 456 HGEIYVSGGSLFYRLLK----YDPRRDEWQE 482
++YV GG + L YD +R+EW+E
Sbjct: 669 GDKLYVVGGYDGHTYLNTVESYDAQRNEWKE 699
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 75.5 bits (184), Expect = 1e-13
Identities = 63/212 (29%), Positives = 94/212 (44%), Gaps = 26/212 (12%)
Query: 353 GLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDG 412
G+ V+ N L+V GG DG + + V C+NP W+ + P+ R L + L+G
Sbjct: 470 GVAVIDNKLYVVGG-----RDG-LKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEG 523
Query: 413 HLYAVGG----ECLLSVERYDPRADRWAPVAPL--PRGAFAVAHEATTCHGEIYVSGG-- 464
+YAVGG L +VER+DP +W VA + PR V + ++Y GG
Sbjct: 524 PMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGV----VALNNKLYAIGGRD 579
Query: 465 --SLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAAGPSGV 522
S + +DP ++W C S R + +GF+Y + G + S +
Sbjct: 580 GSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLY---VVGGHDAPASNHCSRL 636
Query: 523 S--VSRYHCLAKQWSPCVAPLRLPGGPTGLQP 552
S V RY WS VAPL +P + P
Sbjct: 637 SDCVERYDPKGDSWS-TVAPLSVPRDAVAVCP 667
Score = 67.8 bits (164), Expect = 3e-11
Identities = 105/468 (22%), Positives = 180/468 (38%), Gaps = 71/468 (15%)
Query: 141 DLVLEVSGRRLRAHKAVLAARSDYFRARASRDVL-------RVQGVSLTALRLLLADAYS 193
D++L R+ AH+ VL+A SDYF A + DVL R++GV AL L+ AY+
Sbjct: 183 DVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYT 242
Query: 194 GRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLAN------------CYEVLS 241
G + ++ D + ++A A LQL ++ + QL +N C E+L+
Sbjct: 243 GVLQ-LKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELLN 301
Query: 242 AAKRQRLNEL--------------RDAAYCFMSDHYLEVLREPAVFGRL-SGAERDLLLR 286
A + + + + SD + V E +F L D+ R
Sbjct: 302 VAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDD-INVPDEETIFHALMQWVGHDVQNR 360
Query: 287 RRLRAGRAHLLAAALGPAGERAGSRPQSP-SGDADARGDAAVYCFHAAAGEWRELTRLPE 345
+ + L P A S +GD + + + E R + + P
Sbjct: 361 QGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPR 420
Query: 346 GAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQL 405
P + L+ GG+ + + + Y+ T+SW + + R Q
Sbjct: 421 TKPRKST-----VGALYAVGGM------DAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQF 469
Query: 406 RLLALDGHLYAVGG----ECLLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYV 461
+ +D LY VGG + L +VE ++P W + P+ + T G +Y
Sbjct: 470 GVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLG--VATLEGPMYA 527
Query: 462 SGG----SLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAA 517
GG S + ++DP +W S+ + +VAL+ +Y + G G +
Sbjct: 528 VGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYA--IGGRDGSSCLK 585
Query: 518 GPSGVSVSRYHCLAKQWSPCVAPLRLPGGPTGLQPFRCAALDGAIYCV 565
S+ + +WS C AP+ G G+ A +G +Y V
Sbjct: 586 -----SMEYFDPHTNKWSLC-APMSKRRGGVGV-----ATYNGFLYVV 622
Score = 64.7 bits (156), Expect = 2e-10
Identities = 49/151 (32%), Positives = 70/151 (46%), Gaps = 26/151 (17%)
Query: 348 PARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRL 407
P G+ L N L+ GG DG + + ++P T+ WS P+ + R + +
Sbjct: 559 PRSTVGVVALNNKLYAIGG-----RDGSSCLKSMEY-FDPHTNKWSLCAPMSKRRGGVGV 612
Query: 408 LALDGHLYAVGGECLLS----------VERYDPRADRWAPVAPL--PRGAFAVAHEATTC 455
+G LY VGG + VERYDP+ D W+ VAPL PR A AV
Sbjct: 613 ATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVC----PL 668
Query: 456 HGEIYVSGGSLFYRLLK----YDPRRDEWQE 482
++YV GG + L YD +R+EW+E
Sbjct: 669 GDKLYVVGGYDGHTYLNTVESYDAQRNEWKE 699
Score = 54.7 bits (130), Expect = 3e-07
Identities = 34/98 (34%), Positives = 46/98 (46%), Gaps = 4/98 (4%)
Query: 351 GCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLAL 410
G G+ +L+V GG + +R SD V Y+P DSWS V PL R + + L
Sbjct: 609 GVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPL 668
Query: 411 DGHLYAVGG----ECLLSVERYDPRADRWAPVAPLPRG 444
LY VGG L +VE YD + + W P+ G
Sbjct: 669 GDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPVNIG 706
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,549,608
Number of Sequences: 37866
Number of extensions: 1721854
Number of successful extensions: 14372
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 212
Number of HSP's successfully gapped in prelim test: 875
Number of HSP's that attempted gapping in prelim test: 9959
Number of HSP's gapped (non-prelim): 4186
length of query: 623
length of database: 18,247,518
effective HSP length: 108
effective length of query: 515
effective length of database: 14,157,990
effective search space: 7291364850
effective search space used: 7291364850
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.