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Search of human proteins with 7662230
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7662230 ring finger protein 40 [Homo sapiens]
(1001 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7662230 ring finger protein 40 [Homo sapiens] 1941 0.0
gi|34878777 ring finger protein 20 [Homo sapiens] 1072 0.0
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 110 7e-24
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 108 3e-23
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 107 4e-23
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 107 4e-23
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 107 6e-23
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 105 3e-22
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 105 3e-22
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 105 3e-22
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 105 3e-22
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 105 3e-22
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 105 3e-22
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 105 3e-22
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 105 3e-22
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 104 4e-22
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 101 3e-21
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi... 101 3e-21
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 101 4e-21
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 100 7e-21
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 100 1e-20
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 100 1e-20
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 100 1e-20
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 99 2e-20
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 98 3e-20
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 97 1e-19
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 96 1e-19
gi|156104908 myosin heavy chain 6 [Homo sapiens] 96 2e-19
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 94 5e-19
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 94 5e-19
>gi|7662230 ring finger protein 40 [Homo sapiens]
Length = 1001
Score = 1941 bits (5027), Expect = 0.0
Identities = 1001/1001 (100%), Positives = 1001/1001 (100%)
Query: 1 MSGPGNKRAAGDGGSGPPEKKLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNKKLA 60
MSGPGNKRAAGDGGSGPPEKKLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNKKLA
Sbjct: 1 MSGPGNKRAAGDGGSGPPEKKLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNKKLA 60
Query: 61 ERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSS 120
ERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSS
Sbjct: 61 ERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSS 120
Query: 121 APEAPGTQEGPTCDGTPLPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELE 180
APEAPGTQEGPTCDGTPLPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELE
Sbjct: 121 APEAPGTQEGPTCDGTPLPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELE 180
Query: 181 LQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRL 240
LQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRL
Sbjct: 181 LQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRL 240
Query: 241 QDLATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHL 300
QDLATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHL
Sbjct: 241 QDLATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHL 300
Query: 301 AEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAEL 360
AEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAEL
Sbjct: 301 AEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAEL 360
Query: 361 QGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATK 420
QGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATK
Sbjct: 361 QGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATK 420
Query: 421 NSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPIN 480
NSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPIN
Sbjct: 421 NSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPIN 480
Query: 481 REMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGV 540
REMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGV
Sbjct: 481 REMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGV 540
Query: 541 SAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPS 600
SAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPS
Sbjct: 541 SAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPS 600
Query: 601 SRGREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAELK 660
SRGREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAELK
Sbjct: 601 SRGREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAELK 660
Query: 661 KAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKK 720
KAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKK
Sbjct: 661 KAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKK 720
Query: 721 IADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLR 780
IADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLR
Sbjct: 721 IADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLR 780
Query: 781 EKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQG 840
EKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQG
Sbjct: 781 EKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQG 840
Query: 841 SLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREK 900
SLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREK
Sbjct: 841 SLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREK 900
Query: 901 ESFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQEEIKEYKARLTCPCCNTRKKDAVL 960
ESFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQEEIKEYKARLTCPCCNTRKKDAVL
Sbjct: 901 ESFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQEEIKEYKARLTCPCCNTRKKDAVL 960
Query: 961 TKCFHVFCFECVRGRYEARQRKCPKCNAAFGAHDFHRIYIS 1001
TKCFHVFCFECVRGRYEARQRKCPKCNAAFGAHDFHRIYIS
Sbjct: 961 TKCFHVFCFECVRGRYEARQRKCPKCNAAFGAHDFHRIYIS 1001
>gi|34878777 ring finger protein 20 [Homo sapiens]
Length = 975
Score = 1072 bits (2773), Expect = 0.0
Identities = 588/1010 (58%), Positives = 745/1010 (73%), Gaps = 46/1010 (4%)
Query: 1 MSGPGNKRAAGDGGSG-PPEKKLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNKKL 59
MSG GNKRAAG+ G+ PPEKK + E+ TT +E I+LGG+SSTEE+D++ LQ KN+KL
Sbjct: 1 MSGIGNKRAAGEPGTSMPPEKKAAVEDSGTT--VETIKLGGVSSTEELDIRTLQTKNRKL 58
Query: 60 AERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQ---G 116
AE L+QRQA EDELRE IEKLE+RQATDDA+LLIVNRYW+Q DE + +L+ ++ + G
Sbjct: 59 AEMLDQRQAIEDELREHIEKLERRQATDDASLLIVNRYWSQFDENIRIILKRYDLEQGLG 118
Query: 117 ELSSAPEAPGTQEGPTCDGTPLPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEE 176
+L + +A E PEP + ++ + R EPA +F+ L +SSSEE
Sbjct: 119 DLLTERKALVVPE---------PEPDSDSNQERKDDRERGEGQEPAFSFLATLASSSSEE 169
Query: 177 VELELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRE 236
+E +LQ R+E S+ AVS++V D+LQ +VE L +++ S GD+ + EA Q L +E
Sbjct: 170 MESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNS-GDNLIVEEAVQELNSFLAQE 228
Query: 237 NRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKL 296
N RLQ+L LQEKH +S E+S+LQ KV +AE++V +E+ ++DLQWDI+K+RKREQ+L
Sbjct: 229 NMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQRL 288
Query: 297 NKHLAEALEQLNS-GYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEK 355
N+HLAE LE++NS GY V G+ S GG IT++ +KFE +NAELEEN+ELA +R+ ELEK
Sbjct: 289 NRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCELEK 348
Query: 356 LQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGL 415
L+ + + NE+LKV LRS E+VV+ET EYR +Q+QFS+LYNESLQ+K LDEAR L
Sbjct: 349 LRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQLKAHLDEARTL 408
Query: 416 LLATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQ 475
L T+ +H +E +E DE+ L KKLRTEVIQLEDTLAQVRKEYEMLRIEFEQ LAANEQ
Sbjct: 409 LHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQ 468
Query: 476 AGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSA--HSTPNLG 533
AGPINREMRHLISSLQNHNHQLKG+ RYKRKLRE Q+++ K R + SGSA S +
Sbjct: 469 AGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLR-SGSALLQSQSSTE 527
Query: 534 HPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGIT 593
P+D PA K PD+ + + + + + EE+ +
Sbjct: 528 DPKDE----PAELK----------PDSEDLSSQSSASKASQEDANEIKSKRDEEERERER 573
Query: 594 PGAQGPSSRGREPEA---RPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESE 650
+ R RE E R K++L+E E S D+EK K ++ ++KE+E
Sbjct: 574 REKEREREREREKEKEREREKQKLKESE---------KERDSAKDKEKGKHDDGRKKEAE 624
Query: 651 LLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIREL 710
++K L+ ELKKAQESQKEMKLLLDMY+SAPKEQRDKVQLMAAE+K+KAE+++LR R+++L
Sbjct: 625 IIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDL 684
Query: 711 EERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQE 770
E+++++E+KK+ADEDALR+IR EEQIE+LQ+KL KQEEEALLSEMDVTGQAFEDMQE
Sbjct: 685 EDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQE 744
Query: 771 QNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQK 830
QN RL+QQLREKDDANFKLMSERIK+NQIHKLL+EEK+EL +QVL LK+QVDAQL V+K
Sbjct: 745 QNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRK 804
Query: 831 LEEKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPC 890
LEEKE LQ ++G EKEL LR+QALE+NKRKA+EAAQLA+DLK QLE Q +L + Q
Sbjct: 805 LEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDE 864
Query: 891 LAESRAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQEEIKEYKARLTCPC 950
+ E+ +EK+ FN KRAQEDISRLRRKLE +K + DEIL EEIK+YKARLTCPC
Sbjct: 865 IVENSVTKEKDMFNFKRAQEDISRLRRKLETTKKPDNVPKCDEILMEEIKDYKARLTCPC 924
Query: 951 CNTRKKDAVLTKCFHVFCFECVRGRYEARQRKCPKCNAAFGAHDFHRIYI 1000
CN RKKDAVLTKCFHVFCFECV+ RY+ RQRKCPKCNAAFGA+DFHRIYI
Sbjct: 925 CNMRKKDAVLTKCFHVFCFECVKTRYDTRQRKCPKCNAAFGANDFHRIYI 974
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 110 bits (275), Expect = 7e-24
Identities = 156/761 (20%), Positives = 336/761 (44%), Gaps = 94/761 (12%)
Query: 180 ELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRR 239
E++ R+E K ++ E+ +++L + + S+G S +E TR L
Sbjct: 290 EMELRIETQKQTLNARDES-------IKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMH 342
Query: 240 LQDLATQLQEKHHRISLEYSEL----QDKVTSAETKVLEMETTVEDLQWDIEKLRKREQK 295
+ L + L++K S+ E+ ++ SA+TK L+ ++D K+ E+
Sbjct: 343 VHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKD-----SKISSMERG 397
Query: 296 LNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEK 355
L + L E ++ L S +S + Q+ + + + ++E+ +E +S+ A+ E+
Sbjct: 398 L-RDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEE 456
Query: 356 LQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGL 415
L+ + G L+ + + +E+ R+ E LQ + L N+ K ++ +
Sbjct: 457 LKKKAAG-------LQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKES 509
Query: 416 LLATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQ 475
L A E LQ ++ ++LE+ + K+ + ++ E+ Q
Sbjct: 510 LTAK-----------EQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEK---GTQ 555
Query: 476 AGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHP 535
AG I+ +++ ++ + + L+ + + +LR+ + ++ L+ + T N
Sbjct: 556 AGEIH-DLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNT--- 611
Query: 536 EDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPG 595
D+ ++ EE T + KE K+EE+ ++D + +
Sbjct: 612 -DTALTT----LEEALAEKERTIERLKEQRD------RDEREKQEEIDNYKKDLKDL--- 657
Query: 596 AQGPSSRGREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEET-----KRKESE 650
+E + + +L E+E L AS+L+ + +K +T ++K+ E
Sbjct: 658 --------KEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEE 709
Query: 651 LLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIREL 710
LK + ++LKKA E+ E + +M +R+ + KA+AEVD L ++E+
Sbjct: 710 CLK-MESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEV 768
Query: 711 EERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQE 770
E + KKIA+ + R+++ +++ +L+ K K++ +L E + +++ +
Sbjct: 769 ENEKNDKDKKIAELE--RQVKDQNKKVANLKHKEQVEKKKSAQMLEE---ARRREDNLND 823
Query: 771 QNGRLLQQLREKDDANFKL-----MSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQL 825
+ +L LR+KDD +L S +I A + L +EE + QV+ L
Sbjct: 824 SSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAE-----KQVEELL 878
Query: 826 LTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTRLR 885
+ ++K++++ +++ L ++ +L + L +A L E L+++ E + +
Sbjct: 879 MAMEKVKQELESMKAKLSSTQQ--SLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAIS 936
Query: 886 EIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQRKVE 926
E ++ A + S + K+ QE+++ L+R EK R V+
Sbjct: 937 E-----KDANIALLELSSSKKKTQEEVAALKR--EKDRLVQ 970
Score = 70.1 bits (170), Expect = 1e-11
Identities = 101/468 (21%), Positives = 199/468 (42%), Gaps = 41/468 (8%)
Query: 45 EEMDLKVLQFKNKKLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDET 104
+E + VLQ K + L E+L ++ L+ER++ L+ D L + A+ + T
Sbjct: 569 KERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERT 628
Query: 105 VEALLRCHESQGELSSAPEAPGTQEGPTCDGTPLPEPGTSELRDPLLMQLRPPLSEPALA 164
+E L+ + E E ++ +L++ + + L+ LSE +
Sbjct: 629 IER-LKEQRDRDEREKQEEIDNYKK------------DLKDLKEKVSL-LQGDLSEKEAS 674
Query: 165 FV-VALGASSSEEVELELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYSRGDSEPLS 223
+ + ASS L+ R++ + A+ + E +++ ++++ + S +S
Sbjct: 675 LLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMS 734
Query: 224 EAAQAHTRELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQ 283
+ Q L RE R +D +++ Q + R+ E++++ + K+ E+E V+D
Sbjct: 735 DRIQ----HLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQN 790
Query: 284 WDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQ 343
+ L+ +EQ K A+ LE+ SS Q+ S++K + ELEE
Sbjct: 791 KKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSS----QQLQDSLRKKDDRIEELEEAL 846
Query: 344 ELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESL 403
+ AE E + A+ + A RTN +V + E V++ E ++A+ S
Sbjct: 847 RESVQITAEREMVLAQEESA-RTNAEKQVEELLMAMEKVKQ--ELESMKAKLSSTQQSLA 903
Query: 404 QVKTQLDEARGLLLATKNSHLRHIEHMESDEL--GLQKK--------LRTEVIQLEDTLA 453
+ +T L R A + HL + M+ + L + +K L + + ++ +A
Sbjct: 904 EKETHLTNLR----AERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVA 959
Query: 454 QVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISSLQNH-NHQLKGD 500
+++E + L + +Q + N E H SS N NH+ D
Sbjct: 960 ALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPD 1007
Score = 65.9 bits (159), Expect = 2e-10
Identities = 153/801 (19%), Positives = 328/801 (40%), Gaps = 157/801 (19%)
Query: 45 EEMDLKV------LQFKNKKLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVN-RY 97
EEM+L++ L +++ + + LE Q+ + E E+ + +A + + +
Sbjct: 289 EEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLES 348
Query: 98 WAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDGTPLPEPGTSELRDPLLMQLRPP 157
+ E ++LR E +AP++ T+ T E++D + +
Sbjct: 349 LLEQKEKENSMLR-EEMHRRFENAPDSAKTKALQT----------VIEMKDSKISSMERG 397
Query: 158 LS--EPALAFVVALGASSSEEVELELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYS 215
L E + + + GA S+EE E E++ +ME ++ S ++ +VE+L + + S
Sbjct: 398 LRDLEEEIQMLKSNGALSTEEREEEMK-QMEVYRSH-------SKFMKNKVEQLKEELSS 449
Query: 216 R-GDSEPLSEAAQAHTRELGRENRRLQDLATQL---QEKHHRISLEYSELQDKVTSAETK 271
+ E L + A E+G+ + L T+L Q K ++ ++S+ + + +
Sbjct: 450 KEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKES 509
Query: 272 VLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSSSG----------FQ 321
+ E LQ +++ LR R ++ L + +Q+ G+ +G +
Sbjct: 510 LTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVK 569
Query: 322 GGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAE--------------LQGAVRTN 367
++ + +K E L +L + ++ +S ++ LQA+ L RT
Sbjct: 570 ERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTI 629
Query: 368 ERLKVAL----RSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSH 423
ERLK R EE+ + + L+ + SLL + + + L + + + +S
Sbjct: 630 ERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSG 689
Query: 424 LRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREM 483
L+ +++ E+ L++K + E +++E +Q++K +E A +A P EM
Sbjct: 690 LKKDSRLKTLEIALEQK-KEECLKME---SQLKKAHEA---------ALEARASP---EM 733
Query: 484 RHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAP 543
I L+ + RYK + + QAE+ +L N + +D ++
Sbjct: 734 SDRIQHLER-------EITRYKDESSKAQAEVDRLLEILK----EVENEKNDKDKKIAEL 782
Query: 544 APGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRG 603
D K++A ++K +E V ++ Q +
Sbjct: 783 ER----------QVKDQNKKVA----------NLKHKEQVEKKKSAQMLE---------- 812
Query: 604 REPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAELKKAQ 663
EAR R + + + +L + D ++EE R+ ++ E+ AQ
Sbjct: 813 ---EAR-----RREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITA--EREMVLAQ 862
Query: 664 E------SQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRE 717
E ++K+++ +L+ A K K E++ +++++ ++ +
Sbjct: 863 EESARTNAEKQVE-----------------ELLMAMEKVKQELESMKAKLSSTQQSLAEK 905
Query: 718 SKKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQE------Q 771
+ + A RR + EE +E Q L A E++A ++ ++++ + +E +
Sbjct: 906 ETHLTNLRAERR-KHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKRE 964
Query: 772 NGRLLQQLREKDDANFKLMSE 792
RL+QQL+++ KLM++
Sbjct: 965 KDRLVQQLKQQTQNRMKLMAD 985
Score = 59.7 bits (143), Expect = 1e-08
Identities = 89/421 (21%), Positives = 190/421 (45%), Gaps = 46/421 (10%)
Query: 557 TPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRELRE 616
+P+ +KE A + T K++ V EE+ + + + E R +R+L +
Sbjct: 191 SPELKKERALRKDEASKITIWKEQYRVVQEENQH------MQMTIQALQDELRIQRDLNQ 244
Query: 617 ---REGPSLGPPPVASALSRADREKAKVE-ETKRKESELLKGLRAELKKAQESQKE---- 668
++ S P + L+ + ++ E E + KE LL+ E++ E+QK+
Sbjct: 245 LFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNA 304
Query: 669 ----MKLLLDMYKS------APKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRES 718
+K LL+M +S A +E ++ + +A +A+ V L S LE++++ S
Sbjct: 305 RDESIKKLLEMLQSKGLSAKATEEDHERTRRLA---EAEMHVHHLESL---LEQKEKENS 358
Query: 719 KKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFED---MQEQNGRL 775
+ E+ RR A + + + L + +++ +S M+ + E+ M + NG L
Sbjct: 359 --MLREEMHRRFENAPDSAK--TKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGAL 414
Query: 776 LQQLREKDDANFKLMSERIK--ANQIHKLLRE------EKDELGEQVLGLKSQVDAQLLT 827
+ RE++ ++ K N++ +L E + +EL ++ GL++++
Sbjct: 415 STEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQE 474
Query: 828 VQKLEEKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTRLREI 887
+ + + + ALQ L + + + Q +E+ K Q A L+ +++ ++ RL E
Sbjct: 475 LSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEK 534
Query: 888 QPCLAESRAAREKESFNLKRAQEDISRLRRKLE-KQRKVEVYADADEILQEEIKEYKARL 946
+ L + + + +I L+ L+ K+RKV V E LQE++++ + ++
Sbjct: 535 ETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQM 594
Query: 947 T 947
+
Sbjct: 595 S 595
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 108 bits (269), Expect = 3e-23
Identities = 177/926 (19%), Positives = 381/926 (41%), Gaps = 156/926 (16%)
Query: 53 QFKNKKLAERLEQRQA-CE--------DELRERIEKLEKRQATDDATLLIVNRYWAQLDE 103
+ +++KLA+ + + QA C ++ ER E + Q A + + + W +L
Sbjct: 779 EMRDEKLAQLITRTQAMCRGFLARVEYQKMVERRESIFCIQYNVRAFMNVKHWPWMKLYF 838
Query: 104 TVEALLRCHESQGELSSAPEAPGTQEGPTCDGTPLPEPGTSELRDPLLMQLRPPLSEPAL 163
++ LL+ E++ E+++ E + T + E EL + ++ ++
Sbjct: 839 KIKPLLKSAETEKEMANMKE----EFEKTKEELAKTEAKRKELEEKMVTLMQ-------- 886
Query: 164 AFVVALGASSSEEVELELQGRMEFSKAA-----VSRVVEASDRLQRRVEELCQRVYSRGD 218
E+ +L+LQ + E A ++++ +L+ +++E+ +R
Sbjct: 887 -----------EKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTER------ 929
Query: 219 SEPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEMETT 278
+E + EL + R+L+D ++L++ + L ++++ + + E KV +
Sbjct: 930 ----AEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE 985
Query: 279 VEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAE 338
+ L I KL K ++ L + + L+ L AE
Sbjct: 986 MAGLDETIAKLTKEKKALQEAHQQTLDDLQ----------------------------AE 1017
Query: 339 LEENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLL 398
++ L +++ +LE+ +L+G++ +++++ L ++ G+ ++ Q +
Sbjct: 1018 EDKVNTLTKAKI-KLEQQVDDLEGSLEQEKKIRMDLERAKRKL---EGDLKLAQESTMDI 1073
Query: 399 YNESLQVKTQLDEARGLLLATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKE 458
N+ K QLDE L K + ++ DE L +L+ ++ +L+ + ++ +E
Sbjct: 1074 END----KQQLDEK----LKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEE 1125
Query: 459 YEMLRIEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKL 518
E R A +Q ++RE+ + L+ + K++ +AE K+
Sbjct: 1126 IEAERAS---RAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKR----EAEFQKM 1178
Query: 519 RAQASGS---------------AHSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKE 563
R + A S LG D+ ++E + D
Sbjct: 1179 RRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASN 1238
Query: 564 MAPVPGTTTTTTSV------KKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRELRER 617
M V + + E+ EE+ Q + +R + R+L E+
Sbjct: 1239 METVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEK 1298
Query: 618 EGPSLGPPPVASALSRADRE-KAKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMY 676
+ + S LSR + ++EE KR+ E +K A Q S+ + LL + Y
Sbjct: 1299 D-------TLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQY 1351
Query: 677 KSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQ 736
+ +EQ K +L A KA +EV + R++ E + R E + A + +R++ AEE
Sbjct: 1352 E---EEQEAKAELQRAMSKANSEVAQWRTKY-ETDAIQRTEELEEAKKKLAQRLQDAEEH 1407
Query: 737 IEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANF-KLMSE-RI 794
+E + K + ++ ++ L +E++ D++ N +K NF K+++E +
Sbjct: 1408 VEAVNAKCASLEKTKQRLQNEVE---DLMIDVERTNAAC--AALDKKQRNFDKILAEWKQ 1462
Query: 795 KANQIHKLL---REEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTL 851
K + H L ++E L ++ +K+ + L ++ L+ + + LQ + + +++
Sbjct: 1463 KCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQI-- 1520
Query: 852 RSQALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQED 911
E + +L+ + V+ E+Q L E+ A+ E E + R Q +
Sbjct: 1521 ------------AEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLE 1568
Query: 912 ISRLRRKLEKQRKVEVYADADEILQE 937
++++ K E RK+ A+ DE + +
Sbjct: 1569 LNQV--KSEVDRKI---AEKDEEIDQ 1589
Score = 79.7 bits (195), Expect = 1e-14
Identities = 175/978 (17%), Positives = 378/978 (38%), Gaps = 120/978 (12%)
Query: 52 LQFKNKKLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETV------ 105
L K +KL + + + D+L + K+EK + + + + A LDET+
Sbjct: 940 LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKE 999
Query: 106 -EALLRCHESQ-GELSSAPEAPGTQEGPTCDGTPLPEPGTSELRDPLLMQLRPPLSEPAL 163
+AL H+ +L + + T + L +++ ++ L
Sbjct: 1000 KKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKL 1059
Query: 164 AFVVALGASSSEEVELE-----------------LQGRMEFSKAAVSRVVEASDRLQRRV 206
+ L S+ ++E + LQ ++E +A ++ + LQ R+
Sbjct: 1060 EGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARI 1119
Query: 207 EELCQRVYSRGDSEPLSEAAQAH-TRELGRENRRLQDL--ATQLQEKHH----------R 253
EEL + + + S +E ++ +REL + RL++ AT Q + + R
Sbjct: 1120 EELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMR 1179
Query: 254 ISLEYSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEA---LEQLNSG 310
LE + LQ + T+A + ++ E L I+ L++ +QKL K +E ++ L S
Sbjct: 1180 RDLEEATLQHEATAATLRKKHADSVAE-LGEQIDNLQRVKQKLEKEKSEMKMEIDDLASN 1238
Query: 311 YYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAEL---------- 360
+ G + + + EE Q L N A+ +LQ E
Sbjct: 1239 METVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEK 1298
Query: 361 --------QGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQ---FSLL---YNESLQVK 406
+G ++++ R L EE+ ++ LQ+ LL Y E + K
Sbjct: 1299 DTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAK 1358
Query: 407 TQLDEARGLLLAT--------KNSHLRHIEHMESDELGLQKKLR----------TEVIQL 448
+L A + + ++ E +E + L ++L+ + L
Sbjct: 1359 AELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASL 1418
Query: 449 EDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKL 508
E T +++ E E L I+ E+ AA R +++ + + + + +++
Sbjct: 1419 EKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKES 1478
Query: 509 REVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVP 568
R + E+ K++ S L K E D +++A
Sbjct: 1479 RSLSTELFKIKNAYEESLDQLETL--------------KRENKNLQQEISDLTEQIAEGG 1524
Query: 569 GTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVA 628
+KK+ + + + Q A+ R + EL + V
Sbjct: 1525 KRIHELEKIKKQ-VEQEKSELQAALEEAEASLEHEEGKILRIQLELNQ----------VK 1573
Query: 629 SALSRADREK-AKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKV 687
S + R EK ++++ KR +++ +++ L S+ + L + E ++
Sbjct: 1574 SEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEM--EI 1631
Query: 688 QLMAAERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGAT 747
QL A R A + R+ L++ ++ +DALR +EQ+ ++R+
Sbjct: 1632 QLNHANRMAAEALRNYRNTQAILKDT------QLHLDDALRSQEDLKEQLAMVERRANLL 1685
Query: 748 KQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEK 807
+ E E L + ++ T ++ + +++ ++++ N L++ + K ++ E
Sbjct: 1686 QAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEM 1745
Query: 808 DELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRKAVEAA 867
+++ ++ + + + + E+ + Q + +E+ Q ++ + + EA
Sbjct: 1746 EDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAE 1805
Query: 868 QLA-EDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQRK-V 925
QLA + K Q++ ++ R+RE++ + + + L++ + + L + E+ RK +
Sbjct: 1806 QLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNI 1865
Query: 926 EVYADADEILQEEIKEYK 943
D + LQ ++K YK
Sbjct: 1866 LRLQDLVDKLQAKVKSYK 1883
Score = 79.7 bits (195), Expect = 1e-14
Identities = 132/665 (19%), Positives = 269/665 (40%), Gaps = 113/665 (16%)
Query: 175 EEVELELQGRMEFSKAAVSR--------VVEASDRLQRRVEELCQRVYSRGDSEPLSEAA 226
+E + ELQ M + + V++ ++ ++ L+ ++L QR+ D+E EA
Sbjct: 1355 QEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ---DAEEHVEAV 1411
Query: 227 QAHTRELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQWDI 286
A L + +RLQ+ L R + + L K + + + E + E+ ++
Sbjct: 1412 NAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAEL 1471
Query: 287 EKLRKREQKLNKHL-------AEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAEL 339
E +K + L+ L E+L+QL + + + + ++L
Sbjct: 1472 EASQKESRSLSTELFKIKNAYEESLDQLET---------------LKRENKNLQQEISDL 1516
Query: 340 EENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLY 399
E R+ ELEK++ +++ + L+ AL + E G+ +Q + + +
Sbjct: 1517 TEQIAEGGKRIHELEKIKKQVE---QEKSELQAALEEAEASLEHEEGKILRIQLELNQVK 1573
Query: 400 NESLQVKTQLDEARGLLLATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEY 459
+E V ++ E + K +H+R +E M+S L + + R + I+L+ + E
Sbjct: 1574 SE---VDRKIAEKDEEIDQMKRNHIRIVESMQS-TLDAEIRSRNDAIRLKK-----KMEG 1624
Query: 460 EMLRIEFEQNLAANEQAGPINREMR-----------HLISSLQNHNHQLKGDAQRYKRKL 508
++ +E + N AN A R R HL +L++ LK +R+
Sbjct: 1625 DLNEMEIQLN-HANRMAAEALRNYRNTQAILKDTQLHLDDALRS-QEDLKEQLAMVERRA 1682
Query: 509 REVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVP 568
+QAEI +LRA + S + E + R ++
Sbjct: 1683 NLLQAEIEELRATLEQTERSR-KIAEQE------------------LLDASERVQLLHTQ 1723
Query: 569 GTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVA 628
T+ T K E D I + R E + K+ + + +A
Sbjct: 1724 NTSLINTKKK------LETDISQIQGEMEDIIQEARNAEEKAKKAITD-------AAMMA 1770
Query: 629 SALSRADREKAKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQ 688
L + A +E K+ + +K L+ L +A++ + K+Q K++
Sbjct: 1771 EELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ----------LALKGGKKQIQKLE 1820
Query: 689 LMAAERKAKAEVDELRSRIRELEERDRRESKKIAD-----EDALRRIRQAEEQIEHLQRK 743
A R+ + EV+ + R E + R+ +K+ + E+ + I + ++ ++ LQ K
Sbjct: 1821 --ARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAK 1878
Query: 744 LGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDD-ANFKLMSERIKANQIH-K 801
+ + K++ E + +V F +Q + L++ E+ D A ++ R+K+ ++H K
Sbjct: 1879 VKSYKRQAEEAEEQSNVNLSKFRRIQHE----LEEAEERADIAESQVNKLRVKSREVHTK 1934
Query: 802 LLREE 806
++ EE
Sbjct: 1935 IISEE 1939
Score = 63.9 bits (154), Expect = 7e-10
Identities = 128/658 (19%), Positives = 264/658 (40%), Gaps = 106/658 (16%)
Query: 331 KFEMLNAELEENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRM 390
K + L E +E+AN + E EK + EL + + + L E++V E
Sbjct: 839 KIKPLLKSAETEKEMANMK-EEFEKTKEELA-------KTEAKRKELEEKMVTLMQEKND 890
Query: 391 LQAQFSLLYNESLQVKTQLDEARGLLLATK---NSHLRHIEHMESDELGLQKKLRTEVIQ 447
LQ Q + + + D+ L+ TK + ++ + DE + +L + +
Sbjct: 891 LQLQVQAEADSLADAEERCDQ----LIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRK 946
Query: 448 LEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRK 507
LED ++++K+ + L + + + +E + ++N ++ G
Sbjct: 947 LEDECSELKKDIDDLELTLAK----------VEKEKHATENKVKNLTEEMAG-------- 988
Query: 508 LREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPV 567
L E A++ K + + T + E+ V+
Sbjct: 989 LDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVN-------------------------- 1022
Query: 568 PGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPV 627
T T +K E+ V +D +G E E + + +L + G +
Sbjct: 1023 ---TLTKAKIKLEQQV---DDLEG-----------SLEQEKKIRMDLERAKRKLEGDLKL 1065
Query: 628 ASALSR-ADREKAKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDK 686
A + + +K +++E +K+ + GL+++++ Q +++ + ++ +E ++
Sbjct: 1066 AQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEE 1125
Query: 687 VQLMAAERKAKAEVDELRSRI-RELEE-RDRRESKKIADEDALRRIRQAEEQIEHLQRKL 744
++ AER ++A+ ++ RS + RELEE +R E A + ++ E + + ++R L
Sbjct: 1126 IE---AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDL 1182
Query: 745 G-ATKQEEEALLSEMDVTGQAFEDMQEQ--NGRLLQQLREKDDANFKLMSERIKANQ--- 798
AT Q E + + ++ EQ N + ++Q EK+ + K+ + + +N
Sbjct: 1183 EEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETV 1242
Query: 799 ------IHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLR 852
+ K+ R +D+L E +K++ + Q + L + LQ G ++L +
Sbjct: 1243 SKAKGNLEKMCRALEDQLSE----IKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEK 1298
Query: 853 SQALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDI 912
+ R Q E+LK QLE + L SR + + QE
Sbjct: 1299 DTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAK 1358
Query: 913 SRLRRKLEK------QRKVEVYADADEILQEEIKEYKARLTCPCCNTRKK-DAVLTKC 963
+ L+R + K Q + + DA + EE++E K +L + + +AV KC
Sbjct: 1359 AELQRAMSKANSEVAQWRTKYETDAIQ-RTEELEEAKKKLAQRLQDAEEHVEAVNAKC 1415
Score = 43.1 bits (100), Expect = 0.001
Identities = 96/508 (18%), Positives = 209/508 (41%), Gaps = 74/508 (14%)
Query: 41 ISSTEEMDLKVLQFKNKKLAERLEQRQACEDELRER---IEKLEKRQATDDATLLI---- 93
I TEE L+ KKLA+RL+ + + + + +EK ++R + L+I
Sbjct: 1384 IQRTEE-----LEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVER 1438
Query: 94 VNRYWAQLDE--------TVEALLRCHESQGELSSAPEAPGTQEG-----PTCDGTPLPE 140
N A LD+ E +C E+ EL ++ + + L +
Sbjct: 1439 TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQ 1498
Query: 141 PGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELELQGRMEFSKAAVSRVVEASD 200
T + + L Q L+E +A G E+E +++ ++E K+ + +E ++
Sbjct: 1499 LETLKRENKNLQQEISDLTEQ-----IAEGGKRIHELE-KIKKQVEQEKSELQAALEEAE 1552
Query: 201 RLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRISLEYSE 260
E R+ L++ R++ ++ + Q++ H RI
Sbjct: 1553 ASLEHEEGKILRIQLE-----LNQVKSEVDRKIAEKDEEID----QMKRNHIRIVESMQS 1603
Query: 261 LQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSSSGF 320
D + + ++ +E D+ ++ + N+ AEAL + + +
Sbjct: 1604 TLDAEIRSRNDAIRLKKKMEG---DLNEMEIQLNHANRMAAEALRNYRN------TQAIL 1654
Query: 321 QGGQITL--SMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLP 378
+ Q+ L +++ E L +L + AN AE+E+L+A L+ +T K+A
Sbjct: 1655 KDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLE---QTERSRKIA----E 1707
Query: 379 EEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARG----LLLATKNSHLRHIE-----H 429
+E++ + ++L Q + L N +++T + + +G ++ +N+ + +
Sbjct: 1708 QELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAA 1767
Query: 430 MESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPIN------REM 483
M ++EL ++ + +++ L Q K+ + R++ + LA I RE+
Sbjct: 1768 MMAEELKKEQDTSAHLERMKKNLEQTVKDLQH-RLDEAEQLALKGGKKQIQKLEARVREL 1826
Query: 484 RHLISSLQNHNHQLKGDAQRYKRKLREV 511
+ S Q N + ++++RK++E+
Sbjct: 1827 EGEVESEQKRNVEAVKGLRKHERKVKEL 1854
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 107 bits (268), Expect = 4e-23
Identities = 182/821 (22%), Positives = 337/821 (41%), Gaps = 72/821 (8%)
Query: 175 EEVELELQGRMEFSKAAVSRVVEASDRLQRRVEEL-C---QRVYSRGDSEPLS------- 223
+E + G ++ + VS + +A RL+++VE+L C Q R D+E
Sbjct: 1049 QEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDL 1108
Query: 224 EAAQAHTRELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQ 283
+ Q + ++ ++L++ + + ++SL + Q + K+ E++ E+L+
Sbjct: 1109 KLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELE 1168
Query: 284 WDIEKLRKREQKLNKHLAEA---LEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELE 340
++E R ++ K AEA LE+L+ +G +S Q + L ELE
Sbjct: 1169 EELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELE 1228
Query: 341 ENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRM----LQAQFS 396
E + +A L + QAE GA E++ +L+ + +++ +E E RM L A
Sbjct: 1229 EAALRHEATVAALRRKQAE--GAAELGEQVD-SLQRVRQKLEKEKSELRMEVDDLAANVE 1285
Query: 397 LL-------------YNESL-QVKTQLDEARGLL--LATKNSHLRHIEHMESDELG-LQK 439
L Y + L + K +++E + L +T+ L+ ES EL L +
Sbjct: 1286 TLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQ----TESGELSRLLE 1341
Query: 440 KLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKG 499
+ + QL A + E LR + E+ A + +RH L H+ +
Sbjct: 1342 EKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRH-DCDLLREQHEEEA 1400
Query: 500 DAQ-RYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTP 558
+AQ +R L + AE+ + R++ A ++ EEG +
Sbjct: 1401 EAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKC 1460
Query: 559 DNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRELRERE 618
+ ++ T + +++ E + + R E +REL +
Sbjct: 1461 SSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQ 1520
Query: 619 GPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKS 678
S G L E + ET ++E++ L+ ++L + L+ K
Sbjct: 1521 RESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKK 1580
Query: 679 APKEQRDKVQLMAAERKAKAEVDELRSRIRELE------ERDRRESKKIADEDALRRIRQ 732
A + ++ ++Q E + E++E ++ +LE E DR+ ++K DE+ R
Sbjct: 1581 ALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEK--DEECANLRRN 1638
Query: 733 AEEQIEHLQRKLGA-TKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMS 791
+ +E LQ L A T+ EAL + + G D++ Q G +Q E A +LM
Sbjct: 1639 HQRAVESLQASLDAETRARNEALRLKKKMEGD-LNDLELQLGHATRQATEAQAAT-RLMQ 1696
Query: 792 ERIKANQIHKLLREEKD----ELGEQVLGLKSQVDAQLLTVQKLEEKERAL-QGSLGGVE 846
++K Q R+E+ EL EQ L+ + L +LEE AL QG
Sbjct: 1697 AQLKEEQAG---RDEEQRLAAELHEQAQALERRAS---LLAAELEELRAALEQGERSRRL 1750
Query: 847 KELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLK 906
E L LN + L + K++ + Q E++ E R A EK K
Sbjct: 1751 AEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLS-GEVEEAAQERREAEEK----AK 1805
Query: 907 RAQEDISRLRRKLEKQRKVEVYAD-ADEILQEEIKEYKARL 946
+A D + + +L+K++ + + + L++ ++E +ARL
Sbjct: 1806 KAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARL 1846
Score = 95.1 bits (235), Expect = 3e-19
Identities = 170/792 (21%), Positives = 330/792 (41%), Gaps = 114/792 (14%)
Query: 176 EVELELQGRMEFSKAAVSR---VVEASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRE 232
++ L+LQ + A R ++++ +L+ +V+EL +R+ E + +
Sbjct: 935 DLALQLQAEQDNLADAEERCHLLIKSKVQLEGKVKELSERL----------EDEEEVNAD 984
Query: 233 LGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKR 292
L R+L+D T+L++ + L ++ + + + E KV + + L + +L K
Sbjct: 985 LAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKE 1044
Query: 293 EQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAE 352
++ L + +AL L + S ++ L Q+ E L LE+ ++L RM +
Sbjct: 1045 KKALQEAHQQALGDLQAE---EDRVSALTKAKLRLE-QQVEDLECSLEQEKKL---RM-D 1096
Query: 353 LEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEA 412
E+ + +L+G ++ + E V + + L+ + +E Q+ ++++
Sbjct: 1097 TERAKRKLEGDLKLTQ----------ESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDE 1146
Query: 413 R--GLLLATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEML--RIEFEQ 468
+ G + K L+ +EL ++ R V E A+ +E E L R+E
Sbjct: 1147 QLLGAQMQKKIKELQARAEELEEELEAERAARARV---EKQRAEAARELEELSERLEEAG 1203
Query: 469 NLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHS 528
+A ++ G RE + L +L+ A R++ + ++ R QA G+A
Sbjct: 1204 GASAGQREGCRKRE-----AELGRLRRELEEAALRHEATVAALR------RKQAEGAAE- 1251
Query: 529 TPNLGHPEDSGVSAPAPGKEEGGPGPVSTPD---NRKEMAPVPGTTTTTTSVKKEELVPS 585
LG DS ++E + D N + + + +++L +
Sbjct: 1252 ---LGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEA 1308
Query: 586 E---EDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVASALSRADREKAK-V 641
+ E+ Q A R + R L E+E + S LSR A+ +
Sbjct: 1309 KIKVEELQRQLADASTQRGRLQTESGELSRLLEEKEC-------LISQLSRGKALAAQSL 1361
Query: 642 EETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVD 701
EE +R+ E K A Q + + LL + ++ + Q + +L++ KA AEV
Sbjct: 1362 EELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLS---KANAEVA 1418
Query: 702 ELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEM-DV 760
+ RS+ E + R E + A + R+++AEE +E K + ++ + L +E DV
Sbjct: 1419 QWRSKY-EADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDV 1477
Query: 761 T---------GQAFEDMQEQNGRLLQQLREKDDAN------------------FKLMSER 793
T A + Q R L++ R +++ F+L
Sbjct: 1478 TLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGH 1537
Query: 794 IKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRS 853
+A + + L+ E L E++ L QV ++Q+LE+ ++AL+G ++ L
Sbjct: 1538 EEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAE 1597
Query: 854 QALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKR-AQEDI 912
ALEL + K L++QLE Q + E+ LAE +++E NL+R Q +
Sbjct: 1598 GALELEETKT---------LRIQLELSQVK-AEVDRKLAE----KDEECANLRRNHQRAV 1643
Query: 913 SRLRRKLEKQRK 924
L+ L+ + +
Sbjct: 1644 ESLQASLDAETR 1655
Score = 93.2 bits (230), Expect = 1e-18
Identities = 186/846 (21%), Positives = 344/846 (40%), Gaps = 148/846 (17%)
Query: 19 EKKLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNKKLAERLEQRQACEDELRERIE 78
E+ R E T L G E++D LQ +KL + + + D+L +E
Sbjct: 1228 EEAALRHEATVAALRRKQAEGAAELGEQVDS--LQRVRQKLEKEKSELRMEVDDLAANVE 1285
Query: 79 KLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDGTPL 138
L + +A+ + + Y QL E A ++ E Q +L+ A G + + + + L
Sbjct: 1286 TLTRAKASAEK---LCRTYEDQLSE---AKIKVEELQRQLADASTQRGRLQTESGELSRL 1339
Query: 139 PEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELELQGRMEFSKAAVSRVVEA 198
E ++ L+ QL AL A S EE+ +L+ + +K+A++ V+A
Sbjct: 1340 LEE-----KECLISQLSRGK---------ALAAQSLEELRRQLEEESK-AKSALAHAVQA 1384
Query: 199 SD------RLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHH 252
R Q E Q R S+ +E AQ ++ +R ++L +E
Sbjct: 1385 LRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEEL----EEAKK 1440
Query: 253 RISLEYSELQDKVTSAETKV-------LEMETTVEDLQWDIEKLRKREQKLNK---HLAE 302
+++L E ++ V +A K L ++T ED+ ++E+ L+K HL
Sbjct: 1441 KLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLER 1500
Query: 303 ALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQG 362
ALE+ ++ E + ELE Q + EL +L+ +
Sbjct: 1501 ALEERR---------------------RQEEEMQRELEAAQRESRGLGTELFRLRHGHEE 1539
Query: 363 AVRTNERLKVALRSLPEEVVRETGEYRM-------LQAQFSLLYNESLQVKTQLDEARGL 415
A+ E LK ++L EE+ T + + L+ L E +++ L+EA G
Sbjct: 1540 ALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGA 1599
Query: 416 LLATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQ 475
L EL K LR IQLE L+QV+ E + E +E+
Sbjct: 1600 L-----------------ELEETKTLR---IQLE--LSQVKAEVDRKLAE------KDEE 1631
Query: 476 AGPINREMRHLISSLQ---NHNHQLKGDAQRYKRK----LREVQAEIGKLRAQASGSAHS 528
+ R + + SLQ + + + +A R K+K L +++ ++G QA+ + +
Sbjct: 1632 CANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAA 1691
Query: 529 T---------PNLGHPEDSGVSAPAPGKEEGGPGPVS-TPDNRKEMAPVPGTTTTTTSVK 578
T G E+ ++A + + S +E+ + +
Sbjct: 1692 TRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLA 1751
Query: 579 KEELVPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVASALSRADREK 638
++EL+ + E + G ++ ++ EA +L + G + A +E+
Sbjct: 1752 EQELLEATERLNLLHSQNTGLLNQKKKLEA----DLAQLSG----------EVEEAAQER 1797
Query: 639 AKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQ--LMAAERKA 696
+ EE +K + ELKK Q++ ++ + + +E + +++ AA R
Sbjct: 1798 REAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGG 1857
Query: 697 KAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHL-------QRKLGATKQ 749
K +V +L +++RELE E KK A +AL+ +R+ E +++ L ++ L +
Sbjct: 1858 KKQVQKLEAKVRELEAELDAEQKKHA--EALKGVRKHERRVKELAYQAEEDRKNLARMQD 1915
Query: 750 EEEALLSEMDVTGQAFEDMQEQNGRLLQQLR----EKDDANFKLMSERIKANQIHKLLRE 805
+ L S++ + FE+ ++Q L + R E DDA + +AN KL
Sbjct: 1916 LVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHELDDAEERADMAETQAN---KLRAR 1972
Query: 806 EKDELG 811
+D LG
Sbjct: 1973 TRDALG 1978
Score = 57.4 bits (137), Expect = 7e-08
Identities = 102/492 (20%), Positives = 187/492 (38%), Gaps = 49/492 (9%)
Query: 447 QLEDTLAQVRKEYEMLRIEFE---QNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQR 503
+LE+T + +E L ++ + NLA E E HL L QL+G +
Sbjct: 921 ELEETHVSITQEKNDLALQLQAEQDNLADAE-------ERCHL---LIKSKVQLEGKVKE 970
Query: 504 YKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKE 563
+L + + L A+ L D A ++E + +E
Sbjct: 971 LSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEE 1030
Query: 564 MAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPSLG 623
MA + + T KK L + + G + S + + R ++++ + E
Sbjct: 1031 MAALDESVARLTKEKKA-LQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLE----- 1084
Query: 624 PPPVASALSRADREKAKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQ 683
+L + + + E KRK LK + + A + +++++ L S +
Sbjct: 1085 -----CSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQL 1139
Query: 684 RDKV---QLMAAERKAKAEVDELRSRIRELEER--DRRESKKIADEDALRRIRQAEEQIE 738
+V QL+ A+ + K + EL++R ELEE R ++ ++ R+ EE E
Sbjct: 1140 SLRVEDEQLLGAQMQKK--IKELQARAEELEEELEAERAARARVEKQRAEAARELEELSE 1197
Query: 739 HLQRKLGATKQEEEALLSEMDVTGQAFEDMQE---QNGRLLQQLREKDDANFKLMSERIK 795
L+ GA+ + E G+ +++E ++ + LR K + E++
Sbjct: 1198 RLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVD 1257
Query: 796 ANQ-IHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQ 854
+ Q + + L +EK EL +V L + V+ L + EK
Sbjct: 1258 SLQRVRQKLEKEKSELRMEVDDLAANVET--------------LTRAKASAEKLCRTYED 1303
Query: 855 ALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISR 914
L K K E + D Q +QT E+ L E + S A + +
Sbjct: 1304 QLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEE 1363
Query: 915 LRRKLEKQRKVE 926
LRR+LE++ K +
Sbjct: 1364 LRRQLEEESKAK 1375
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 107 bits (268), Expect = 4e-23
Identities = 165/764 (21%), Positives = 330/764 (43%), Gaps = 84/764 (10%)
Query: 177 VELELQGRMEF---SKAAVSRVVEASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTREL 233
VE +LQ R+E + + R+ +++ L++++E++ + R EA Q +L
Sbjct: 666 VEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQ---LEALQQEHLDL 722
Query: 234 GRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQWD-------I 286
++ Q+ ++ + Y ELQ ++ + + E T+ LQ + +
Sbjct: 723 MKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAAL 782
Query: 287 EKLRKREQKLNK---HLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQ 343
+ + +++L++ L E E+ + + GQ+ Q+ L ++++ +
Sbjct: 783 QAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIK 842
Query: 344 E--LANSRMAELEKLQAELQGAV-----RTNERLKVALRSLPEEVVRETGEYRMLQAQFS 396
E L M E + A + + T +RL L+ L +E+++ GE R +A+ S
Sbjct: 843 EQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELS 902
Query: 397 LLYNESLQVKTQLDEARGLLLATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVR 456
L+ E QV+ + + G L + + H++S L K+ V + + L +
Sbjct: 903 RLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQS--LQFDKEQMVAVTEANEAL---K 957
Query: 457 KEYEMLRIEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYK-------RKLR 509
K+ E L+ E + + +Q +MR L S L + ++K + Y+ R+L+
Sbjct: 958 KQIEELQQEARKAITEQKQ------KMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQ 1011
Query: 510 E-------VQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRK 562
E AE+G+LRAQ GS+ S+ L H + A S K
Sbjct: 1012 EALAAKEAADAELGQLRAQ-GGSSDSSLAL-HERIQALEAELQAVSH------SKTLLEK 1063
Query: 563 EMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPSL 622
E+ V T+ +E+++ E++ Q + G + R E + EL +G
Sbjct: 1064 ELQEVIALTSQELEESREKVLELEDELQE-SRGFRKKIKRLEESNKKLALELEHEKGKLT 1122
Query: 623 GPPPVASALSRADREKAKVEET--KRKESELLK---GLRAELKKAQESQKEMKLLLDMYK 677
G +AL RE + ET ++E++L++ ++A L++ +E ++MK L+ +
Sbjct: 1123 GLGQSNAAL----REHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQ 1178
Query: 678 SAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQI 737
++ +++++KV + E+ A A+V+ +RR K + E L +++ +
Sbjct: 1179 ASLEKEKEKVNSL-KEQVAAAKVE---------AGHNRRHFKAASLE--LSEVKKELQAK 1226
Query: 738 EHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKAN 797
EHL +KL A E + L Q Q + QL+ + +S++ N
Sbjct: 1227 EHLVQKLQA---EADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGN 1283
Query: 798 QIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALE 857
Q + L+ E D+ ++ LK Q+D LT Q+ ++ LQ L V+ EL + + L
Sbjct: 1284 QEMENLKWEVDQKEREIQSLKQQLD---LTEQQGRKELEGLQQLLQNVKSELEMAQEDLS 1340
Query: 858 LNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKE 901
+ ++ +LK ++ + + ++++ L A KE
Sbjct: 1341 MTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKTRKE 1384
Score = 85.1 bits (209), Expect = 3e-16
Identities = 159/846 (18%), Positives = 337/846 (39%), Gaps = 111/846 (13%)
Query: 101 LDETVEALLRCHESQGELSSAPEAPGTQEGPTCDGTPLPEPGTSELRDPLLMQLRPPLSE 160
+ + ++A H+ QG+ + ++ C L E +E ++ +L L+ +
Sbjct: 361 IKDVLQAAAAEHQDQGQEVNGEVR--SRRDSICSSVSL-ESSAAETQEEMLQVLKEKMRL 417
Query: 161 PALAFVVALGASSSEEVELELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYSRGDS- 219
++L AS + + + ELQ ++ + VE S Q+R + L V + S
Sbjct: 418 EGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSC 477
Query: 220 -------EPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKV 272
L +A L N LQ +E++ R+ + ++Q + S + V
Sbjct: 478 WDLERAMTDLQNMLEAKNASLASSNNDLQ----VAEEQYQRLMAKVEDMQRSMLSKDNTV 533
Query: 273 LEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKF 332
++ + LQ +++++ L L + +++S S + Q+ L+ +
Sbjct: 534 HDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISS----LQSVRQWYQQQLALAQEAR 589
Query: 333 EMLNAELEENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQ 392
L E+ Q ++ LE L+ E N L L ++E G +
Sbjct: 590 VRLQGEMAHIQVGQMTQAGLLEHLKLE-------NVSLSQQLTETQHRSMKEKGR---IA 639
Query: 393 AQFSLLYNESLQVKTQLDEARGLLLATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTL 452
AQ + + L + + + + R +E E + LQ ++ LE L
Sbjct: 640 AQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQ-RMADSAASLEQQL 698
Query: 453 AQVRKEYEMLRIEFEQNLAANEQAG-PINREMRHLISSLQNHNHQLKGDAQRYKRKLREV 511
QV+ + ++ +Q L A +Q + +++ +LQ+ L Y E+
Sbjct: 699 EQVK----LTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYD----EL 750
Query: 512 QAEIGKLRAQASGSAHSTPNLGHPE---DSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVP 568
QA +G+L+ +A+ + L + + ++ + A GKEE G + +E
Sbjct: 751 QARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEE----- 805
Query: 569 GTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVA 628
T+ T +++E + S G ++ A K+++++ + L
Sbjct: 806 -TSETLEKLREELAIKS------------GQVEHLQQETAALKKQMQKIKEQFL------ 846
Query: 629 SALSRADREKAKVEETKR---KESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRD 685
++K VE +R + +L+ L+A K+ KE++ ++
Sbjct: 847 -------QQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELR-------------QE 886
Query: 686 KVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIAD-EDALRRIRQAEEQIEHLQRKL 744
+Q+ +R A+AE+ L + ++ + +AD E L+ ++ +++E + L
Sbjct: 887 LMQVHGEKRTAEAELSRLHREVAQVRQH-------MADLEGHLQSAQKERDEMETHLQSL 939
Query: 745 GATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREK-DDANFKLMSERIKANQIHKLL 803
K++ A+ + + E++Q++ + + + ++K L S + + HK
Sbjct: 940 QFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAY 999
Query: 804 REEKDELG---EQVLGLKSQVDAQLLTVQK---LEEKERALQGSLGGVEKELTLRSQALE 857
L ++ L K DA+L ++ + AL + +E EL S +
Sbjct: 1000 ENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKT 1059
Query: 858 LNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRR 917
L +++ E L +LE + ++ E++ L ESR R+K +KR +E +L
Sbjct: 1060 LLEKELQEVIALTSQ---ELEESREKVLELEDELQESRGFRKK----IKRLEESNKKLAL 1112
Query: 918 KLEKQR 923
+LE ++
Sbjct: 1113 ELEHEK 1118
Score = 61.6 bits (148), Expect = 4e-09
Identities = 78/347 (22%), Positives = 154/347 (44%), Gaps = 47/347 (13%)
Query: 633 RADREKAKVEETKRKESELLKGLRAE--------LKKAQESQKEMKLLLDMYKSAPKEQR 684
R E A ++ + ++ LL+ L+ E + S KE + + +
Sbjct: 591 RLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADML 650
Query: 685 DKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIAD-----EDALRRIR----QAEE 735
D+ ++AK V+E R E E +R +++AD E L +++ Q ++
Sbjct: 651 DQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQ 710
Query: 736 QIEHLQRK-LGATKQ---EEEALLSE---MDVTGQAFEDMQEQNGRLLQQLREKDDANFK 788
Q+E LQ++ L KQ +EAL S +D ++++Q + G L + ++D
Sbjct: 711 QLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICL 770
Query: 789 LMSERI---KANQIHKLLREEKD-----------ELGEQVLGLKSQVDAQLLTVQKLEEK 834
L +E+I A Q K +EE D E E + L+ ++ + V+ L+++
Sbjct: 771 LQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQE 830
Query: 835 ERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAES 894
AL+ + ++++ + +E +R A QL +LK + + + L+E++ L +
Sbjct: 831 TAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQV 890
Query: 895 RAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQEEIKE 941
+ + A+ ++SRL R++ + R + AD + LQ KE
Sbjct: 891 HGEK-------RTAEAELSRLHREVAQVR--QHMADLEGHLQSAQKE 928
Score = 37.7 bits (86), Expect = 0.054
Identities = 31/166 (18%), Positives = 76/166 (45%), Gaps = 4/166 (2%)
Query: 759 DVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLK 818
DV A + Q+Q + ++R + D+ +S A + +EE ++ ++ + L+
Sbjct: 363 DVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAET----QEEMLQVLKEKMRLE 418
Query: 819 SQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLE 878
Q++A L + +++ LQ L + +L + + ++++ + + LK
Sbjct: 419 GQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCW 478
Query: 879 HVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQRK 924
++ + ++Q L A+ + +L+ A+E RL K+E ++
Sbjct: 479 DLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQR 524
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 107 bits (267), Expect = 6e-23
Identities = 210/979 (21%), Positives = 394/979 (40%), Gaps = 137/979 (13%)
Query: 45 EEMDLKVLQFKNKKLAERLEQRQACEDELR--ERIEKLEKRQATDDATLLIVNRYWAQLD 102
E M K++Q + + A EQR A E++L+ +R ++ R+ + L +QL
Sbjct: 967 ELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQL-----QSQLQ 1021
Query: 103 ETVEALLRCHESQGELSSAPEAPGTQEGPTCDGTPLPEPGTSELRDPLLMQL--RPPLSE 160
E LL E++ E S A QE +G L E SE + L ++ + LSE
Sbjct: 1022 REQEELLARLEAEKEELSEEIAALQQERD--EGLLLAE---SEKQQALSLKESEKTALSE 1076
Query: 161 PALAFVVALGASS--SEEVELELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYSRGD 218
+ +L S E + + Q R E ++ V+ + L+ + EE
Sbjct: 1077 KLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREE---------- 1126
Query: 219 SEPLSEAAQAHTRELGRENRRLQDLATQLQE---KHHRISLEYSELQDKVTSAETKVLEM 275
AA AH +E+ R + +DL Q + + + L+D ++LE
Sbjct: 1127 ------AAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEA 1180
Query: 276 ETTVEDLQWDIEKLRKREQKLNKHLAEALEQLN----SGYYVSGSSSGFQGGQITLSMQK 331
+ + + Q E R+ +L + L E ++ S + + + +I+L
Sbjct: 1181 QRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISL---- 1236
Query: 332 FEMLNAELEENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRML 391
++ N + E+ L + K EL+ ++ ER ++ R E + L
Sbjct: 1237 -KLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARR----------ELQEL 1285
Query: 392 QAQFSLLYNESLQVKTQLDEARGLLLATKNSHLRHIEHMESDELGLQKKL-----RTEVI 446
+ Q +L +E+ ++ +L E +G L + + + + LGL+++L EV+
Sbjct: 1286 RRQMKMLDSENTRLGRELAELQGRLALGERAE----KESRRETLGLRQRLLKGEASLEVM 1341
Query: 447 QLEDTLAQ--VRKEYEMLRIEFEQNLAANEQA-GPINREMRHL----------------- 486
+ E +AQ ++++ R + L + E+A G +++ H
Sbjct: 1342 RQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAEL 1401
Query: 487 ---ISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQAS-----GSAHSTPNLGHPEDS 538
+S+ + L+ + R + + R +A++G LR+ G A S P
Sbjct: 1402 GLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSP 1461
Query: 539 GVSAPAPGKEEG--GPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGA 596
APA G EG P + + +P P T+ + + E + + +F A
Sbjct: 1462 ARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSA 1521
Query: 597 QGPSSRGREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLR 656
Q R + R+L E E A L +A E EE +R L G++
Sbjct: 1522 QRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAES---EEARRSVDGRLSGVQ 1578
Query: 657 AELKKAQES----QKEMKLLLDMY----------KSAPKEQRDKVQLMAA--------ER 694
AEL +ES ++E + LD +S + ++K+ M A +R
Sbjct: 1579 AELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKR 1638
Query: 695 KAKAEVDELRSRIRELEERDRR-----ESKKIADEDALRRIRQAEEQIEHLQRKLGATKQ 749
+ K +D SR +LE + R + ++ D + + +++++ LQR++ ++
Sbjct: 1639 RLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEV 1698
Query: 750 EEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDA----NFKLMSERIKANQIHKLL-- 803
+ L ++ A ++E G L ++R +A + L S R K + K L
Sbjct: 1699 KAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTA 1758
Query: 804 -REEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGG-----VEKELTLRSQALE 857
++ L E++ + + L E+ + L+G + VE E L+
Sbjct: 1759 CEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREV 1818
Query: 858 LNKRKAVEAAQLAEDLKVQLEH--VQTRLREIQPCLAESRAAREKESFNLKRAQEDISRL 915
L +R+ EAA L K+Q E +Q RL +Q LA+ A + + + R ++D L
Sbjct: 1819 LRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVAL 1878
Query: 916 RRKLEKQRKVEVYADADEI 934
RR L+K + ++ + D +
Sbjct: 1879 RRTLDKVEREKLRSHEDTV 1897
Score = 90.9 bits (224), Expect = 5e-18
Identities = 191/899 (21%), Positives = 355/899 (39%), Gaps = 121/899 (13%)
Query: 49 LKVLQFKNKKLAERLEQRQACEDELRERIEKLEKRQ--ATDDATLL--IVNRYWAQLDE- 103
L+V Q + ++L + E+ QA ++ELR + ++LE+ Q A D + + R QL++
Sbjct: 612 LQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQL 671
Query: 104 ------TVEALLRCHESQGELSSAPEAPGTQEGPTCDGTPLPEPGTSELRDPLL-MQLRP 156
+ L+ E+ + + ++ + E G EL + ++
Sbjct: 672 EGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEE 731
Query: 157 PLSEPALAFVVALGASSS-------------EEVELELQGRMEFSKAAVSRVVEASDRLQ 203
+ +L+ + AL S + EE + LQGR ++ + E +RL+
Sbjct: 732 ASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLE 791
Query: 204 R-RVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRISLEYSELQ 262
R+E+ R G +A +A ++L L QL + ++S EL+
Sbjct: 792 ELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELE 851
Query: 263 DKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSSSGFQG 322
A+ +V +E + E L K L L A + G +S ++
Sbjct: 852 QARREAQRQVEALERAAREK----EALAKEHAGLAVQLVAAERE---GRTLSEEAT---- 900
Query: 323 GQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVV 382
L ++K E L L E Q A E+L+AE Q + E L L L ++++
Sbjct: 901 ---RLRLEK-EALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQII 956
Query: 383 RETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHLRHIEHMESDELGLQKKLR 442
T E L + L+ + +Q + EA+ L + +H ++ ++ ++ ++L
Sbjct: 957 -ATQEKASLDKE--LMAQKLVQAER---EAQASLREQRAAHEEDLQRLQREKEAAWRELE 1010
Query: 443 TEVIQLEDTLAQVRKE----YEMLRIEFEQNLAANEQAGP-----INREMRHLISSLQNH 493
E QL+ L + ++E E + E + +AA +Q E + +S ++
Sbjct: 1011 AERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESE 1070
Query: 494 NHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPAPGKEEGGPG 553
L + L + E+ + + A + + S + +EE
Sbjct: 1071 KTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAA 1130
Query: 554 PVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRE 613
+E A G + + EEL + G R +R+
Sbjct: 1131 HAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGL-------RRELLEAQRK 1183
Query: 614 LREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAELKKAQESQKEMKLLL 673
LRE + A L R+ E AK E R+ +E LR+ +KKA+ + +KL
Sbjct: 1184 LRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNE---ELRSAVKKAESERISLKL-- 1238
Query: 674 DMYKSAPKEQRDKVQLMAAERKAKA-EVDELRSRIRELEERDRRESKKIADEDALRRIRQ 732
A +++ K+ L+ R A E ELR+ ++E+ ER R E+++ L+ +R+
Sbjct: 1239 -----ANEDKEQKLALLEEARTAVGKEAGELRTGLQEV-ERSRLEARR-----ELQELRR 1287
Query: 733 AEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSE 792
+ ++ +LG E + L+ G+ E + L+Q K +A+ ++M +
Sbjct: 1288 QMKMLDSENTRLGRELAELQGRLA----LGERAEKESRRETLGLRQRLLKGEASLEVMRQ 1343
Query: 793 RIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSL---GGVEKEL 849
++ Q + L+E++ E +ER L GSL G EK+
Sbjct: 1344 ELQVAQ--RKLQEQEGE---------------------FRTRERRLLGSLEEARGTEKQQ 1380
Query: 850 TLRSQALELNKRKA-VEAAQL----------AEDLKVQLEHVQTRLREIQPCLAESRAA 897
++ LEL A EAA+L A+ L+ +L V+ + R + L R+A
Sbjct: 1381 LDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSA 1439
Score = 76.6 bits (187), Expect = 1e-13
Identities = 183/830 (22%), Positives = 331/830 (39%), Gaps = 127/830 (15%)
Query: 179 LELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGREN- 237
L LQ + + +SRV + + + +EL + SE L +A + EL +
Sbjct: 77 LSLQEENQLLQQELSRVEDLLAQSRAERDELA--IKYNAVSERLEQALRLEPGELETQEP 134
Query: 238 ----RRLQDLATQLQEKH--HRISLE-YSE-----------LQDKVTSAETKVLEMETTV 279
R+ +L QLQE+ +R L+ Y E LQ K+ + + E+E +
Sbjct: 135 RGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQL 194
Query: 280 EDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAEL 339
+ ++E+ R R+ + ++ L AL +L S S + + + + N L
Sbjct: 195 LERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNA-MLREQLDQAGSANQAL 253
Query: 340 EENQELANSRMAELEKLQAELQGAVRTNE------------------RLKVALRSLPEEV 381
E+ + K + A R E R V R L EV
Sbjct: 254 SEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEV 313
Query: 382 VRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHLRHIEHMESDELGLQKKL 441
T E +LQ L + L + GL LA + +E + L+++L
Sbjct: 314 KMFT-ERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAA-LEKQALLQAQLEEQL 371
Query: 442 RTEVIQLEDTLAQVRKEYEMLRIEF-----EQNLAA------NEQAGPINREMRHLISSL 490
R +V++ +D LAQ + + ++ + + E LA N + +N+++ + +L
Sbjct: 372 RDKVLREKD-LAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEAL 430
Query: 491 QNHNHQLKG-----DAQRYKRKLREVQAEI---GKLRAQASGSAHSTP--NLGHPEDSGV 540
++ Q + D + ++ LR++ + + Q SGS + N SG
Sbjct: 431 ESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQ 490
Query: 541 SAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTT----TSVKKEEL--------VPSEED 588
P+P + PG +P R+ +P ++T +++ K +L + +D
Sbjct: 491 RTPSPPRRSS-PGRGRSP--RRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQD 547
Query: 589 FQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVA--------SALSRADREKAK 640
G S R + LR++ ++ A SA REK+
Sbjct: 548 LLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSN 607
Query: 641 VEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERK----- 695
+ + + + + LR E +K Q +Q+E++ D + +EQ D VQ A R+
Sbjct: 608 LAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLE---EEQEDAVQDGARVRRELERS 664
Query: 696 --------------AKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQ 741
AK V+ + R +RD +++K +AL + ++E
Sbjct: 665 HRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSM 724
Query: 742 RKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHK 801
KL A + + LS++ ++ + RL+ QL E+ A L + +A Q
Sbjct: 725 TKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSA---LQGRQRQAEQEAT 781
Query: 802 LLREEKDELGEQVLGLKSQVDAQLL--TVQKLEEKERALQGSLGGVEKELTLRSQALELN 859
+ REE++ L E L L+ +V Q L +++ E+ + AL+ L + E RSQ E
Sbjct: 782 VAREEQERLEE--LRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHE---RSQLQE-- 834
Query: 860 KRKAVEAAQLAEDLKVQLEHVQTRLREIQPCL-AESRAAREKESFNLKRA 908
+ AQL+ L + + ++ RE Q + A RAAREKE+ + A
Sbjct: 835 -----QLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHA 879
Score = 57.8 bits (138), Expect = 5e-08
Identities = 141/701 (20%), Positives = 256/701 (36%), Gaps = 148/701 (21%)
Query: 324 QITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVRTN--ERLKVALRSLPEEV 381
++ L++++ E N E ++ + ++ LE L+ + Q A+ T E L+ LR L + V
Sbjct: 401 ELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAV 460
Query: 382 VRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHLRHIEHMESDELGLQ-KK 440
+ ++ L + D + G L S G ++
Sbjct: 461 LSDSESGVQLSGS-----------ERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRR 509
Query: 441 LRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGD 500
+ TLA + +++ + E + + +R +S ++ L+
Sbjct: 510 GPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQ 569
Query: 501 AQRYKRKL-------REVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPAPGKEEGGPG 553
QR + K + Q E+ +LR+ + NL H ++E
Sbjct: 570 LQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKL 629
Query: 554 PVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRE 613
+ + R++ ++ L +ED A +R R R R+
Sbjct: 630 QAAQEELRRQ---------------RDRLEEEQED-------AVQDGARVRRELERSHRQ 667
Query: 614 LREREGP----SLGPPPVASALSRADREKAKVEETKRKESELLKGLRAELKKAQESQKEM 669
L + EG + V ALSRA ++ ++ K + +E L KA+ + E+
Sbjct: 668 LEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALT-------KAEAGRVEL 720
Query: 670 KLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADEDALRR 729
+L + ++ +D + ++A ++ A+ D+L D R
Sbjct: 721 ELSMTKLRAEEASLQDSLSKLSALNESLAQ-DKL---------------------DLNRL 758
Query: 730 IRQAEEQIEHLQRKLGATKQEE----------EALLSEMDVTGQAFE------------- 766
+ Q EE+ LQ + +QE E L E +V Q E
Sbjct: 759 VAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEAL 818
Query: 767 ------------DMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQV 814
+QEQ +L +QL ++ + E + + + EK+ L ++
Sbjct: 819 EQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEH 878
Query: 815 LGLKSQVDAQLLTVQKLEE-------KERALQGSLGGVEKELT----------LRSQALE 857
GL Q+ A + L E ++ AL+GSL V+++L QAL
Sbjct: 879 AGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALL 938
Query: 858 LNK----------RKAVEAAQ--LAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNL 905
L K R+ + A Q + D ++ + + RE Q L E RAA E++ L
Sbjct: 939 LAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEED---L 995
Query: 906 KRAQEDISRLRRKLEKQRKVEVYADADEILQEEIKEYKARL 946
+R Q + R+LE +R A LQ E +E ARL
Sbjct: 996 QRLQREKEAAWRELEAER-----AQLQSQLQREQEELLARL 1031
Score = 46.6 bits (109), Expect = 1e-04
Identities = 60/274 (21%), Positives = 123/274 (44%), Gaps = 18/274 (6%)
Query: 659 LKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERD--RR 716
L +AQE + ++ ++ +S+ Q L A + A++ L + IRE+ R+ +
Sbjct: 5 LARAQEVELTLETVIQTLESSVLCQEKG--LGARDLAQDAQITSLPALIREIVTRNLSQP 62
Query: 717 ESKKIADEDALRRIRQAEEQIEHLQRKLGATKQ---EEEALLSEMDVTGQAFEDMQEQNG 773
ES + + + +E+ + LQ++L + + A E+ + A + EQ
Sbjct: 63 ESPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQAL 122
Query: 774 RLLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEE 833
RL E + L+ + + ++ + L+EE+ ++ + Q VQ+L+
Sbjct: 123 RLEPGELETQEPR-GLVRQSV---ELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQG 178
Query: 834 KERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTR---LREIQPC 890
K + +E++L RS LE + + E +Q E ++LE Q R L ++
Sbjct: 179 KILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAM 238
Query: 891 LAE----SRAAREKESFNLKRAQEDISRLRRKLE 920
L E + +A + S ++++ D +R R++LE
Sbjct: 239 LREQLDQAGSANQALSEDIRKVTNDWTRCRKELE 272
Score = 46.6 bits (109), Expect = 1e-04
Identities = 114/530 (21%), Positives = 209/530 (39%), Gaps = 64/530 (12%)
Query: 368 ERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHLRHI 427
E ++ ALR +E+ E L+ Q S L + +++ + D A S R +
Sbjct: 1505 EAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSA--------TSRARQL 1556
Query: 428 EHM--ESDELGLQKKLRTEVIQLEDTLAQ--VRKEYEMLRIEFEQNLAANEQAGPINREM 483
+ ES+E R +Q E L + VR+ R +Q E+
Sbjct: 1557 QKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESEL 1616
Query: 484 R---HLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASG--SAHSTPNLGHPEDS 538
R IS ++ + +L+GD +R K L ++ KL Q LG +
Sbjct: 1617 RASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDRE 1676
Query: 539 GVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQG 598
+ + + V+ + + GT T L EE + GA
Sbjct: 1677 AQAQALQDRVDSLQRQVADSEVKA------GTLQLTVERLNGALAKVEE-----SEGALR 1725
Query: 599 PSSRG-REPEARPKRELREREGPSLGPPPVASALS--------RADREKAKVEETKRKES 649
RG E A+ L +L +A R D + + E +++ S
Sbjct: 1726 DKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSS 1785
Query: 650 EL------LKGLRAELK----KAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAE 699
L L+G A+L+ +A+ ++++ +L + + VQ + ER+ E
Sbjct: 1786 SLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQE 1845
Query: 700 -VDELRSRIRELEERDRRESKKIA-----DEDALRRIRQAEEQIEHLQRKLGATKQEEEA 753
+ L+ + +LE ++RE ++ A D ALRR E+ E L+ + E
Sbjct: 1846 RLGSLQRALAQLEA-EKREVERSALRLEKDRVALRRTLDKVER-EKLRSHEDTVRLSAEK 1903
Query: 754 LLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQ 813
+ +TG E + Q R +QQL +A ++ + Q+ ++++ EL ++
Sbjct: 1904 GRLDRTLTGAELELAEAQ--RQIQQL----EAQVVVLEQSHSPAQLEVDAQQQQLELQQE 1957
Query: 814 VLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRKA 863
V L+S AQ T + LE +ERA + + G+E++++ L+ R++
Sbjct: 1958 VERLRS---AQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELRRS 2004
Score = 40.4 bits (93), Expect = 0.008
Identities = 83/380 (21%), Positives = 155/380 (40%), Gaps = 63/380 (16%)
Query: 612 RELREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAELKK------AQES 665
R L + E P L P ++L E +++ + +LL RAE + A
Sbjct: 57 RNLSQPESPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSE 116
Query: 666 QKEMKLLLDMYKSAPKEQRDKV-QLMAAERKAKAEVDELRSRIRELEERDRRESKKIADE 724
+ E L L+ + +E R V Q + R+ + E R +++ +E +R+++ +
Sbjct: 117 RLEQALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRL 176
Query: 725 DA-----LRRIRQAEEQI-----EHLQRKLGATK--QEEEALLSEMDVTGQAFEDMQEQN 772
+R + E+Q+ E Q++L T+ Q+ E+ L ++ Q + + N
Sbjct: 177 QGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVN 236
Query: 773 GRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDE----------------------- 809
L +QL + AN L + K R+E +
Sbjct: 237 AMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRL 296
Query: 810 --LGEQVLGLKSQV-DAQLLTVQ-------KLEEKERALQGSLGGVEKELTL-RSQALEL 858
L QV+G + V + ++ T + +L RA+Q + G+ L L S+A
Sbjct: 297 LLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAA 356
Query: 859 NKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRK 918
+++A+ AQL E L+ ++ LRE LA+ + + + +L ++ ++
Sbjct: 357 LEKQALLQAQLEEQLRDKV------LREKD--LAQQQMQSDLDKADLSARVTELGLAVKR 408
Query: 919 LEKQ--RKVEVYADADEILQ 936
LEKQ K +V D E L+
Sbjct: 409 LEKQNLEKDQVNKDLTEKLE 428
Score = 32.7 bits (73), Expect = 1.8
Identities = 32/108 (29%), Positives = 53/108 (49%), Gaps = 13/108 (12%)
Query: 411 EARGLLLATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNL 470
E+ LL AT+ + L ++ E ++L L+ E+ ++ED LAQ R E + L I++
Sbjct: 63 ESPVLLPATEMASLLSLQ--EENQL-----LQQELSRVEDLLAQSRAERDELAIKYNAVS 115
Query: 471 AANEQAGPI------NREMRHLISSLQNHNHQLKGDAQRYKRKLREVQ 512
EQA + +E R L+ QL+ + Y+RKL+ Q
Sbjct: 116 ERLEQALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQ 163
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 105 bits (261), Expect = 3e-22
Identities = 207/923 (22%), Positives = 357/923 (38%), Gaps = 152/923 (16%)
Query: 56 NKKLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQ 115
++ + E+L Q QA +E+ EK+E+ Q + + Y QL T +A L
Sbjct: 1241 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL-VTYKAQLE----- 1294
Query: 116 GELSSAPEAPGTQEGPTCDGTPLPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSE 175
++S + P Q G SE + V L SE
Sbjct: 1295 -PVASPAKKPKVQSG----------------------------SESVIQEYVDLRTHYSE 1325
Query: 176 EVELELQGRMEFSKAAVSRVVEASDRL--QRRVEELCQRVYSRGDSEPLSEAAQAHTREL 233
L Q ++F + R+ E +RL Q+R EE + E + A+AH +
Sbjct: 1326 LTTLTSQ-YIKFISETLRRM-EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1383
Query: 234 GRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEM----ETTVEDLQWDIEKL 289
+ R ++L ++QE+ R + Q + S + ++ ++ E ++ E
Sbjct: 1384 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1443
Query: 290 RKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSR 349
+ ++ + + QL + G + G + + L A EE +
Sbjct: 1444 ERSRLRIEEEIRVVRLQLEATERQRGGAEG-----------ELQALRARAEEAEAQKRQA 1492
Query: 350 MAELEKLQAELQGAVRTNERLKVALRSLPE---EVVRETGEYRMLQAQFSLLYNESLQVK 406
E E+L+ ++Q + + +V L S + E RE + R LQA L +
Sbjct: 1493 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE--KQRALQALEEL--------R 1542
Query: 407 TQLDEARGLLLATKNSHLRHIE-----HMESDELGLQKKLRT---EVIQLEDTLAQVRKE 458
Q +EA L + R ++ S E LQ K + + QLE +L +
Sbjct: 1543 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1602
Query: 459 YEMLRIEFEQNLAANEQAGPINREMRHLISSLQ---NHNHQLKGDAQRYKRKLREVQAEI 515
LR E E+ +A E + Q N +L+ A+ ++ QAE
Sbjct: 1603 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1662
Query: 516 GKLRAQASGSAHSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTT 575
K + +A A G E+ V ++E K+ GT
Sbjct: 1663 EKQKEEAEREARRR---GKAEEQAVRQRELAEQE----------LEKQRQLAEGTAQQRL 1709
Query: 576 SVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVASALSRAD 635
+ ++E + E QG +R+L E E L+R
Sbjct: 1710 AAEQELIRLRAETEQG-----------------EQQRQLLEEE------------LARLQ 1740
Query: 636 REKAKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRD----KVQLMA 691
RE A + KR+E L AEL K + EM++LL A +E R Q +
Sbjct: 1741 REAAAATQ-KRQE------LEAELAKVRA---EMEVLLASKARAEEESRSTSEKSKQRLE 1790
Query: 692 AERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGAT---K 748
AE E+ E +R+R L E +R+ +++A+EDA R+ +AE + +G K
Sbjct: 1791 AEAGRFRELAEEAARLRALAEEAKRQ-RQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1849
Query: 749 QEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKD 808
E E L E + + + E ++L E+ + + ER+ Q+ K E +
Sbjct: 1850 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA--QLRKASDSELE 1907
Query: 809 E---LGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTL---RSQALELNKRK 862
L E L + QV+ ++L ++ EK A G E EL L RS A + + K
Sbjct: 1908 RQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELELGRIRSNAEDTLRSK 1962
Query: 863 AVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQ 922
+ A ++ E + R RE + + +S AA E+ + K A E++ RL+ K+E+
Sbjct: 1963 EQAELEAARQRQLAAEE-ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2021
Query: 923 RKVEVYADADEILQEEIKEYKAR 945
R++ A+ + Q ++ + A+
Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQ 2044
Score = 105 bits (261), Expect = 3e-22
Identities = 193/887 (21%), Positives = 363/887 (40%), Gaps = 150/887 (16%)
Query: 177 VELELQGRMEFSKAAV---SRVVEASDRLQRRVEELCQRVY--------SRGDSEPLSEA 225
++ ELQ + S+A + +R EA++R + R+EE + V RG +E +A
Sbjct: 1418 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1477
Query: 226 AQAHTRELGRENRRLQD----LATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTV-- 279
+A E + R+ Q+ L Q+Q++ R EL +V + E + +
Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1537
Query: 280 -EDLQWDIE----KLRKREQKLNKHLAEALE--QLNSGYYVSGSSSGF--QGGQITLSMQ 330
E+L+ E +LR+ E + + + ALE Q ++ + + F + Q+ S+Q
Sbjct: 1538 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1597
Query: 331 KFEMLNAELEENQELANSRMAELEKLQAELQGAV-----RTNERLKVALRSLPEEVVRET 385
+ + A+L E E + AE E+ + E + + + NE L++ L++ EEV ++
Sbjct: 1598 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA--EEVAQQK 1655
Query: 386 GEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHLRHIEHMESDELGLQK------ 439
+ QA+ E+ + + +A + + + +E G +
Sbjct: 1656 S---LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1712
Query: 440 ----KLRTEVIQ-------LEDTLAQVRKEYEML---RIEFEQNLAANEQAGPINREMRH 485
+LR E Q LE+ LA++++E R E E LA + EM
Sbjct: 1713 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK------VRAEMEV 1766
Query: 486 LISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPAP 545
L++S + + +++ K++L +AE G+ R A +A L +
Sbjct: 1767 LLASKARAEEESRSTSEKSKQRL---EAEAGRFRELAEEAAR----LRALAEEAKRQRQL 1819
Query: 546 GKEEGGPGPVSTPDNRKEMAPVPGTTT---TTTSVKKEELVPSEEDFQGITPGAQGPSSR 602
+E+ E G T T + +E E + + R
Sbjct: 1820 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1879
Query: 603 GREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEET---KRKESELLKGLRAEL 659
E A+ K ++ ER L AS S +R+K VE+T +R+ E + L+A
Sbjct: 1880 LEEQAAQHKADIEER----LAQLRKASD-SELERQKGLVEDTLRQRRQVEEEILALKASF 1934
Query: 660 KKAQESQKEMKLLLDMYKSAPKE---QRDKVQLMAAERKAKAEVDELRSRIRELEERDRR 716
+KA + E++L L +S ++ +++ +L AA ++ A +E R R E +R
Sbjct: 1935 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR----EAEERV 1990
Query: 717 ESKKIADEDALRRIRQAEEQIEHLQRKLGATKQ--------------------------E 750
+ A+E+A R+ + A E++E L+ K+ ++ E
Sbjct: 1991 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2050
Query: 751 EEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSE----RIKANQIHKLLREE 806
E+A + Q + +Q +L QLR + +A + E R++A + R +
Sbjct: 2051 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2110
Query: 807 KDEL------GEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNK 860
+E E+ ++Q A ++K E+E A + E+ + QA +
Sbjct: 2111 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ---AEQAALRQKQAADAEM 2167
Query: 861 RKAVEAAQLAEDLKVQLEHVQTRLR---------------EIQPCLAES------RAARE 899
K + A+ K Q+E T LR E+Q AE+ R+ E
Sbjct: 2168 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2227
Query: 900 KESFNLKRAQEDISRLRRKLEKQRKVEVYADAD---EILQEEIKEYK 943
+E F+++ E++S+L+ ++E + + + D D LQEE ++ K
Sbjct: 2228 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2274
Score = 78.6 bits (192), Expect = 3e-14
Identities = 163/822 (19%), Positives = 326/822 (39%), Gaps = 105/822 (12%)
Query: 152 MQLRPPLSEPALAFVVALGASSSEEVELELQ-GRM--------------EFSKAAVSRVV 196
++ R + E LA + +++ + ELEL+ GR+ E A ++
Sbjct: 1917 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1976
Query: 197 EASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGR------ENRRLQDLATQLQEK 250
+R +R EE Q+ S E + +A E+ R E RRL++ A Q +
Sbjct: 1977 AEEERRRREAEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2034
Query: 251 HHRISLE------YSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEAL 304
+++ E +E + + + K E++ T++ Q +++LR + + EA
Sbjct: 2035 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2094
Query: 305 EQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAEL-QGA 363
E + + + Q +++ E L EE + A EKL+ E Q A
Sbjct: 2095 E--------ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2146
Query: 364 VRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSH 423
R + + ALR ++ + M + ++L+ K Q+++ L T
Sbjct: 2147 ARRAQAEQAALRQ------KQAADAEM--EKHKKFAEQTLRQKAQVEQE----LTTLRLQ 2194
Query: 424 LRHIEHMES---DELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPIN 480
L +H ++ +EL ++L+ E + +QV +E +R++ E+ ++ I
Sbjct: 2195 LEETDHQKNLLDEEL---QRLKAEATEAARQRSQVEEELFSVRVQMEE---LSKLKARIE 2248
Query: 481 REMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGV 540
E R LI + K + QR+ ++ E ++ + A+ S +A L + +
Sbjct: 2249 AENRALIL-------RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2301
Query: 541 SAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPG-AQGP 599
+ E+ + + + +E+ +ED + + A+
Sbjct: 2302 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2361
Query: 600 SSRGREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAEL 659
R EA +R+L + A+R K +V E R ++ + +
Sbjct: 2362 QGFQRTLEAERQRQLEMS--------------AEAERLKLRVAEMSRAQARAEEDAQRFR 2407
Query: 660 KKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERK-AKAEVDELRSRIRELEERDRRES 718
K+A+E ++ L + A +E+ VQ + +R+ + + + LR I ELE RE
Sbjct: 2408 KQAEEIGEK----LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE----REK 2459
Query: 719 KKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQ 778
+K+ E L +++ E Q ++ L T+ +++ LSE D Q ++++ +L Q
Sbjct: 2460 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2519
Query: 779 LREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERAL 838
++ E KA Q+ + + ++ ++ ++ L + ++ + EE R
Sbjct: 2520 FQD----------EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2569
Query: 839 QGSLGGVEKELTLRSQALELNKRKAVEAAQLAED----LKVQLEHVQTRLREIQPCLAES 894
Q L +E++ + + L ++ E QL E+ E V L
Sbjct: 2570 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2629
Query: 895 RAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQ 936
R A + + + + LRRK+ QR E + E LQ
Sbjct: 2630 RDALDGPAAEAE-PEHSFDGLRRKVSAQRLQEAGILSAEELQ 2670
Score = 76.3 bits (186), Expect = 1e-13
Identities = 154/802 (19%), Positives = 309/802 (38%), Gaps = 97/802 (12%)
Query: 19 EKKLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNKKLAERLEQRQACEDELRERIE 78
+K L+ EE+ R + E + KV + + +L ER EQ A + +L + E
Sbjct: 1991 QKSLAAEEEAARQ-----RKAALEEVERLKAKVEEAR--RLRERAEQESARQLQLAQ--E 2041
Query: 79 KLEKR-QATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDGTP 137
+KR QA + A V + +L +T+ Q E S + G E
Sbjct: 2042 AAQKRLQAEEKAHAFAVQQKEQELQQTL---------QQEQSVLDQLRGEAEAARRAAEE 2092
Query: 138 LPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELELQGRMEFSKAAVSRVVE 197
E R+ Q R + E L S+ E+ + Q + K E
Sbjct: 2093 AEEARVQAEREAA--QSRRQVEEAE-----RLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2145
Query: 198 ASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRISLE 257
A+ R Q L Q+ + + E + A+ R+ + + L L QL+E H+ +L
Sbjct: 2146 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2205
Query: 258 YSELQDKVTSAETKVLEMETTVEDLQW-------DIEKLRKREQKLNKHLAEALEQLNSG 310
ELQ ++ + T+ + VE+ + ++ KL+ R + N+ L ++ N+
Sbjct: 2206 DEELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI-LRDKDNTQ 2263
Query: 311 YYVSGSSSGF-----QGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVR 365
++ + + +++++ Q+ L EE +LA R A EK+ E AV+
Sbjct: 2264 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE--DLAQQR-ALAEKMLKEKMQAVQ 2320
Query: 366 TNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQL-DEARGLLLATKNSHL 424
RLK L + + + Q Q L + Q+ QL +E +G +
Sbjct: 2321 EATRLKAEAELLQQ-------QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373
Query: 425 RHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMR 484
R +E E +L+ V ++ A+ ++ + R + E+ + +E
Sbjct: 2374 RQLEMSAEAE-----RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2428
Query: 485 HLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPA 544
L+ +L+ Q DA+R + + E++ E KL+ +A + + + +
Sbjct: 2429 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET 2488
Query: 545 PGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGR 604
++ + R+ ++E E+ FQ AQ + R
Sbjct: 2489 QALQQSFLSEKDSLLQRERFI-------------EQEKAKLEQLFQDEVAKAQ----QLR 2531
Query: 605 EPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAELKKAQE 664
E + R ++++ + R A +EE +R++ E +G+R + ++ Q+
Sbjct: 2532 EEQQRQQQQMEQER----------------QRLVASMEEARRRQHEAEEGVRRKQEELQQ 2575
Query: 665 SQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADE 724
+++ + ++ + R+++QL+ + +A E + + + + D
Sbjct: 2576 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDG 2635
Query: 725 DALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDD 784
A + E + L+RK+ A + +E +LS ++ A Q + +L ++D
Sbjct: 2636 PAAE--AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA------QGHTTVDELARRED 2687
Query: 785 ANFKLMSERIKANQIHKLLREE 806
L A + K E+
Sbjct: 2688 VRHYLQGRSSIAGLLLKATNEK 2709
Score = 74.7 bits (182), Expect = 4e-13
Identities = 209/1050 (19%), Positives = 386/1050 (36%), Gaps = 179/1050 (17%)
Query: 19 EKKLSREEKTTTTLIEPIRLGGISSTEEM-DLKVLQFKNKKLAERLEQRQACEDELRERI 77
E + +RE++ +E +RL + + +V + + ++A QR A E EL+ +
Sbjct: 1524 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA-EAELQSKR 1582
Query: 78 EKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDGTP 137
++ A + +L + AQL E E R + Q E A E +
Sbjct: 1583 ASFAEKTAQLERSLQEEHVAVAQLREEAE---RRAQQQAEAERAREEAEREL-------- 1631
Query: 138 LPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELELQGRMEFSKAAVSRVVE 197
E + + L ++L+ + A EE E E + R + + AV +
Sbjct: 1632 --ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1689
Query: 198 ASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRISLE 257
A L++ QR + G ++ A Q E RL+ Q +++ + E
Sbjct: 1690 AEQELEK------QRQLAEGTAQQRLAAEQ--------ELIRLRAETEQGEQQRQLLEEE 1735
Query: 258 YSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSS 317
+ LQ + +A K E+E ++ K+R + L A A E+ S S
Sbjct: 1736 LARLQREAAAATQKRQELEA-------ELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1788
Query: 318 SGFQGGQITLSMQKFEMLNAELEEN-------QELANSRMAELEKLQAELQGAVRTNERL 370
+ G+ ++ L A EE +E A + AE E++ AE A+ RL
Sbjct: 1789 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1848
Query: 371 KVALRSLPEEVVRETGEYRMLQA----QFSLLYNESLQVKTQLDEARGLLLATKNSHLRH 426
K +E E R L Q L ++ Q K ++E L +S L
Sbjct: 1849 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1908
Query: 427 IEHMESDELGLQKKLRTEVIQL-------------------------EDTLA-------- 453
+ + D L ++++ E++ L EDTL
Sbjct: 1909 QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELE 1968
Query: 454 -----QVRKEYEMLRIEFEQ----NLAANEQAGPINREMRHLISSLQ---NHNHQLKGDA 501
Q+ E E R E E+ +LAA E+A + + L+ +L+ A
Sbjct: 1969 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2028
Query: 502 QRYKRKLREVQAEIGKLRAQASGSAHSTP--------NLGHPEDSGVSAPAPGKEEGGPG 553
++ + ++ E + R QA AH+ ++ V G+ E
Sbjct: 2029 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2088
Query: 554 PVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRE 613
+ + A + + E L S E+ AQ + + R+ +
Sbjct: 2089 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2148
Query: 614 LREREGPSLGPPPVASA--------LSRADREKAKVEET--------------KRKESEL 651
+ E +L A A + R+KA+VE+ K E
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2208
Query: 652 LKGLRAELKKA--QESQKEMKLLL---------------------------DMYKSAPKE 682
L+ L+AE +A Q SQ E +L D + +E
Sbjct: 2209 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2268
Query: 683 QRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQR 742
+ +K++ +A E + + +R+R+L E D + + +A E L+ QA ++ L
Sbjct: 2269 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA-EKMLKEKMQAVQEATRL-- 2325
Query: 743 KLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKL 802
K E E L + ++ + +QE ++ QQL E+ + +
Sbjct: 2326 -----KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE--------- 2371
Query: 803 LREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRK 862
R+ + E+ + LK +V + EE + + +E+ + EL ++
Sbjct: 2372 -RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ----AEEIGEKLHRTELATQE 2426
Query: 863 AVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRK--LE 920
V Q E + Q +H RLRE L + ++E+ L+ E++ ++++ L+
Sbjct: 2427 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQ 2486
Query: 921 KQRKVE--VYADADEILQEE--IKEYKARL 946
+ + ++ ++ D +LQ E I++ KA+L
Sbjct: 2487 ETQALQQSFLSEKDSLLQRERFIEQEKAKL 2516
Score = 55.8 bits (133), Expect = 2e-07
Identities = 129/664 (19%), Positives = 256/664 (38%), Gaps = 70/664 (10%)
Query: 16 GPPEKKLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNKKLAERLEQRQACEDELRE 75
G E E+ ++ R S + + + L+ ++ A+ Q QA ++LR+
Sbjct: 2081 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2140
Query: 76 RIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDG 135
E+ R+A + L + + +A + H+ E + +A QE T
Sbjct: 2141 EAEQEAARRAQAEQAAL-------RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2193
Query: 136 TPLPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELE----LQGRMEFSKAA 191
L D L +L+ +E A S V++E L+ R+E A
Sbjct: 2194 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2253
Query: 192 VSRVVEASDRLQRRVEELCQRVYSRGDSEP-LSEAAQ--AHTRELGRENRRLQDLATQLQ 248
+ ++ D QR ++E +++ + LS AAQ A R+L E DLA Q
Sbjct: 2254 L--ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE-----DLAQQRA 2306
Query: 249 EKHHRISLEYSELQDKVT-SAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQL 307
+ + +Q+ AE ++L+ + E Q +L++ ++++ + LAE +
Sbjct: 2307 LAEKMLKEKMQAVQEATRLKAEAELLQQQK--ELAQEQARRLQEDKEQMAQQLAEETQGF 2364
Query: 308 NSGYYVSGSSS---GFQGGQITLSMQKFEMLNAELEEN------------QELANSRMAE 352
+ ++ L + + A EE+ ++L + +A
Sbjct: 2365 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2424
Query: 353 LEK------LQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVK 406
EK L+ + Q + ERL+ A+ L E + E ++LQ + + +++Q +
Sbjct: 2425 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM--QTVQQE 2482
Query: 407 TQLDEARGL---LLATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLR 463
L E + L L+ K+S L+ +E ++ L++ + EV + + + +++ + +
Sbjct: 2483 QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2542
Query: 464 IEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQAS 523
E ++ +A+ E+A E + Q QL+ ++ + L E + + + Q
Sbjct: 2543 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL-REQLQLL 2601
Query: 524 GSAHSTPNLGHPEDSGVSAPA-----PGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVK 578
H L H E+ S A P + GP + + G ++ +
Sbjct: 2602 EEQHRAA-LAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQR 2657
Query: 579 KEEL-VPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVASALSRADRE 637
+E + S E+ Q + G R + R + G +A L +A E
Sbjct: 2658 LQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQ---------GRSSIAGLLLKATNE 2708
Query: 638 KAKV 641
K V
Sbjct: 2709 KLSV 2712
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 105 bits (261), Expect = 3e-22
Identities = 207/923 (22%), Positives = 357/923 (38%), Gaps = 152/923 (16%)
Query: 56 NKKLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQ 115
++ + E+L Q QA +E+ EK+E+ Q + + Y QL T +A L
Sbjct: 1245 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL-VTYKAQLE----- 1298
Query: 116 GELSSAPEAPGTQEGPTCDGTPLPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSE 175
++S + P Q G SE + V L SE
Sbjct: 1299 -PVASPAKKPKVQSG----------------------------SESVIQEYVDLRTHYSE 1329
Query: 176 EVELELQGRMEFSKAAVSRVVEASDRL--QRRVEELCQRVYSRGDSEPLSEAAQAHTREL 233
L Q ++F + R+ E +RL Q+R EE + E + A+AH +
Sbjct: 1330 LTTLTSQ-YIKFISETLRRM-EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1387
Query: 234 GRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEM----ETTVEDLQWDIEKL 289
+ R ++L ++QE+ R + Q + S + ++ ++ E ++ E
Sbjct: 1388 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1447
Query: 290 RKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSR 349
+ ++ + + QL + G + G + + L A EE +
Sbjct: 1448 ERSRLRIEEEIRVVRLQLEATERQRGGAEG-----------ELQALRARAEEAEAQKRQA 1496
Query: 350 MAELEKLQAELQGAVRTNERLKVALRSLPE---EVVRETGEYRMLQAQFSLLYNESLQVK 406
E E+L+ ++Q + + +V L S + E RE + R LQA L +
Sbjct: 1497 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE--KQRALQALEEL--------R 1546
Query: 407 TQLDEARGLLLATKNSHLRHIE-----HMESDELGLQKKLRT---EVIQLEDTLAQVRKE 458
Q +EA L + R ++ S E LQ K + + QLE +L +
Sbjct: 1547 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1606
Query: 459 YEMLRIEFEQNLAANEQAGPINREMRHLISSLQ---NHNHQLKGDAQRYKRKLREVQAEI 515
LR E E+ +A E + Q N +L+ A+ ++ QAE
Sbjct: 1607 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1666
Query: 516 GKLRAQASGSAHSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTT 575
K + +A A G E+ V ++E K+ GT
Sbjct: 1667 EKQKEEAEREARRR---GKAEEQAVRQRELAEQE----------LEKQRQLAEGTAQQRL 1713
Query: 576 SVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVASALSRAD 635
+ ++E + E QG +R+L E E L+R
Sbjct: 1714 AAEQELIRLRAETEQG-----------------EQQRQLLEEE------------LARLQ 1744
Query: 636 REKAKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRD----KVQLMA 691
RE A + KR+E L AEL K + EM++LL A +E R Q +
Sbjct: 1745 REAAAATQ-KRQE------LEAELAKVRA---EMEVLLASKARAEEESRSTSEKSKQRLE 1794
Query: 692 AERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGAT---K 748
AE E+ E +R+R L E +R+ +++A+EDA R+ +AE + +G K
Sbjct: 1795 AEAGRFRELAEEAARLRALAEEAKRQ-RQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1853
Query: 749 QEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKD 808
E E L E + + + E ++L E+ + + ER+ Q+ K E +
Sbjct: 1854 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA--QLRKASDSELE 1911
Query: 809 E---LGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTL---RSQALELNKRK 862
L E L + QV+ ++L ++ EK A G E EL L RS A + + K
Sbjct: 1912 RQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELELGRIRSNAEDTLRSK 1966
Query: 863 AVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQ 922
+ A ++ E + R RE + + +S AA E+ + K A E++ RL+ K+E+
Sbjct: 1967 EQAELEAARQRQLAAEE-ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2025
Query: 923 RKVEVYADADEILQEEIKEYKAR 945
R++ A+ + Q ++ + A+
Sbjct: 2026 RRLRERAEQESARQLQLAQEAAQ 2048
Score = 105 bits (261), Expect = 3e-22
Identities = 193/887 (21%), Positives = 363/887 (40%), Gaps = 150/887 (16%)
Query: 177 VELELQGRMEFSKAAV---SRVVEASDRLQRRVEELCQRVY--------SRGDSEPLSEA 225
++ ELQ + S+A + +R EA++R + R+EE + V RG +E +A
Sbjct: 1422 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1481
Query: 226 AQAHTRELGRENRRLQD----LATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTV-- 279
+A E + R+ Q+ L Q+Q++ R EL +V + E + +
Sbjct: 1482 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1541
Query: 280 -EDLQWDIE----KLRKREQKLNKHLAEALE--QLNSGYYVSGSSSGF--QGGQITLSMQ 330
E+L+ E +LR+ E + + + ALE Q ++ + + F + Q+ S+Q
Sbjct: 1542 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1601
Query: 331 KFEMLNAELEENQELANSRMAELEKLQAELQGAV-----RTNERLKVALRSLPEEVVRET 385
+ + A+L E E + AE E+ + E + + + NE L++ L++ EEV ++
Sbjct: 1602 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA--EEVAQQK 1659
Query: 386 GEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHLRHIEHMESDELGLQK------ 439
+ QA+ E+ + + +A + + + +E G +
Sbjct: 1660 S---LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1716
Query: 440 ----KLRTEVIQ-------LEDTLAQVRKEYEML---RIEFEQNLAANEQAGPINREMRH 485
+LR E Q LE+ LA++++E R E E LA + EM
Sbjct: 1717 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK------VRAEMEV 1770
Query: 486 LISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPAP 545
L++S + + +++ K++L +AE G+ R A +A L +
Sbjct: 1771 LLASKARAEEESRSTSEKSKQRL---EAEAGRFRELAEEAAR----LRALAEEAKRQRQL 1823
Query: 546 GKEEGGPGPVSTPDNRKEMAPVPGTTT---TTTSVKKEELVPSEEDFQGITPGAQGPSSR 602
+E+ E G T T + +E E + + R
Sbjct: 1824 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1883
Query: 603 GREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEET---KRKESELLKGLRAEL 659
E A+ K ++ ER L AS S +R+K VE+T +R+ E + L+A
Sbjct: 1884 LEEQAAQHKADIEER----LAQLRKASD-SELERQKGLVEDTLRQRRQVEEEILALKASF 1938
Query: 660 KKAQESQKEMKLLLDMYKSAPKE---QRDKVQLMAAERKAKAEVDELRSRIRELEERDRR 716
+KA + E++L L +S ++ +++ +L AA ++ A +E R R E +R
Sbjct: 1939 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR----EAEERV 1994
Query: 717 ESKKIADEDALRRIRQAEEQIEHLQRKLGATKQ--------------------------E 750
+ A+E+A R+ + A E++E L+ K+ ++ E
Sbjct: 1995 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2054
Query: 751 EEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSE----RIKANQIHKLLREE 806
E+A + Q + +Q +L QLR + +A + E R++A + R +
Sbjct: 2055 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2114
Query: 807 KDEL------GEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNK 860
+E E+ ++Q A ++K E+E A + E+ + QA +
Sbjct: 2115 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ---AEQAALRQKQAADAEM 2171
Query: 861 RKAVEAAQLAEDLKVQLEHVQTRLR---------------EIQPCLAES------RAARE 899
K + A+ K Q+E T LR E+Q AE+ R+ E
Sbjct: 2172 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2231
Query: 900 KESFNLKRAQEDISRLRRKLEKQRKVEVYADAD---EILQEEIKEYK 943
+E F+++ E++S+L+ ++E + + + D D LQEE ++ K
Sbjct: 2232 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2278
Score = 78.6 bits (192), Expect = 3e-14
Identities = 163/822 (19%), Positives = 326/822 (39%), Gaps = 105/822 (12%)
Query: 152 MQLRPPLSEPALAFVVALGASSSEEVELELQ-GRM--------------EFSKAAVSRVV 196
++ R + E LA + +++ + ELEL+ GR+ E A ++
Sbjct: 1921 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1980
Query: 197 EASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGR------ENRRLQDLATQLQEK 250
+R +R EE Q+ S E + +A E+ R E RRL++ A Q +
Sbjct: 1981 AEEERRRREAEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2038
Query: 251 HHRISLE------YSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEAL 304
+++ E +E + + + K E++ T++ Q +++LR + + EA
Sbjct: 2039 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2098
Query: 305 EQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAEL-QGA 363
E + + + Q +++ E L EE + A EKL+ E Q A
Sbjct: 2099 E--------ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2150
Query: 364 VRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSH 423
R + + ALR ++ + M + ++L+ K Q+++ L T
Sbjct: 2151 ARRAQAEQAALRQ------KQAADAEM--EKHKKFAEQTLRQKAQVEQE----LTTLRLQ 2198
Query: 424 LRHIEHMES---DELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPIN 480
L +H ++ +EL ++L+ E + +QV +E +R++ E+ ++ I
Sbjct: 2199 LEETDHQKNLLDEEL---QRLKAEATEAARQRSQVEEELFSVRVQMEE---LSKLKARIE 2252
Query: 481 REMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGV 540
E R LI + K + QR+ ++ E ++ + A+ S +A L + +
Sbjct: 2253 AENRALIL-------RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2305
Query: 541 SAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPG-AQGP 599
+ E+ + + + +E+ +ED + + A+
Sbjct: 2306 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2365
Query: 600 SSRGREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAEL 659
R EA +R+L + A+R K +V E R ++ + +
Sbjct: 2366 QGFQRTLEAERQRQLEMS--------------AEAERLKLRVAEMSRAQARAEEDAQRFR 2411
Query: 660 KKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERK-AKAEVDELRSRIRELEERDRRES 718
K+A+E ++ L + A +E+ VQ + +R+ + + + LR I ELE RE
Sbjct: 2412 KQAEEIGEK----LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE----REK 2463
Query: 719 KKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQ 778
+K+ E L +++ E Q ++ L T+ +++ LSE D Q ++++ +L Q
Sbjct: 2464 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2523
Query: 779 LREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERAL 838
++ E KA Q+ + + ++ ++ ++ L + ++ + EE R
Sbjct: 2524 FQD----------EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2573
Query: 839 QGSLGGVEKELTLRSQALELNKRKAVEAAQLAED----LKVQLEHVQTRLREIQPCLAES 894
Q L +E++ + + L ++ E QL E+ E V L
Sbjct: 2574 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2633
Query: 895 RAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQ 936
R A + + + + LRRK+ QR E + E LQ
Sbjct: 2634 RDALDGPAAEAE-PEHSFDGLRRKVSAQRLQEAGILSAEELQ 2674
Score = 76.3 bits (186), Expect = 1e-13
Identities = 154/802 (19%), Positives = 309/802 (38%), Gaps = 97/802 (12%)
Query: 19 EKKLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNKKLAERLEQRQACEDELRERIE 78
+K L+ EE+ R + E + KV + + +L ER EQ A + +L + E
Sbjct: 1995 QKSLAAEEEAARQ-----RKAALEEVERLKAKVEEAR--RLRERAEQESARQLQLAQ--E 2045
Query: 79 KLEKR-QATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDGTP 137
+KR QA + A V + +L +T+ Q E S + G E
Sbjct: 2046 AAQKRLQAEEKAHAFAVQQKEQELQQTL---------QQEQSVLDQLRGEAEAARRAAEE 2096
Query: 138 LPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELELQGRMEFSKAAVSRVVE 197
E R+ Q R + E L S+ E+ + Q + K E
Sbjct: 2097 AEEARVQAEREAA--QSRRQVEEAE-----RLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2149
Query: 198 ASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRISLE 257
A+ R Q L Q+ + + E + A+ R+ + + L L QL+E H+ +L
Sbjct: 2150 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2209
Query: 258 YSELQDKVTSAETKVLEMETTVEDLQW-------DIEKLRKREQKLNKHLAEALEQLNSG 310
ELQ ++ + T+ + VE+ + ++ KL+ R + N+ L ++ N+
Sbjct: 2210 DEELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI-LRDKDNTQ 2267
Query: 311 YYVSGSSSGF-----QGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVR 365
++ + + +++++ Q+ L EE +LA R A EK+ E AV+
Sbjct: 2268 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE--DLAQQR-ALAEKMLKEKMQAVQ 2324
Query: 366 TNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQL-DEARGLLLATKNSHL 424
RLK L + + + Q Q L + Q+ QL +E +G +
Sbjct: 2325 EATRLKAEAELLQQ-------QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2377
Query: 425 RHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMR 484
R +E E +L+ V ++ A+ ++ + R + E+ + +E
Sbjct: 2378 RQLEMSAEAE-----RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2432
Query: 485 HLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPA 544
L+ +L+ Q DA+R + + E++ E KL+ +A + + + +
Sbjct: 2433 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET 2492
Query: 545 PGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGR 604
++ + R+ ++E E+ FQ AQ + R
Sbjct: 2493 QALQQSFLSEKDSLLQRERFI-------------EQEKAKLEQLFQDEVAKAQ----QLR 2535
Query: 605 EPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAELKKAQE 664
E + R ++++ + R A +EE +R++ E +G+R + ++ Q+
Sbjct: 2536 EEQQRQQQQMEQER----------------QRLVASMEEARRRQHEAEEGVRRKQEELQQ 2579
Query: 665 SQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADE 724
+++ + ++ + R+++QL+ + +A E + + + + D
Sbjct: 2580 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDG 2639
Query: 725 DALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDD 784
A + E + L+RK+ A + +E +LS ++ A Q + +L ++D
Sbjct: 2640 PAAE--AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA------QGHTTVDELARRED 2691
Query: 785 ANFKLMSERIKANQIHKLLREE 806
L A + K E+
Sbjct: 2692 VRHYLQGRSSIAGLLLKATNEK 2713
Score = 74.7 bits (182), Expect = 4e-13
Identities = 209/1050 (19%), Positives = 386/1050 (36%), Gaps = 179/1050 (17%)
Query: 19 EKKLSREEKTTTTLIEPIRLGGISSTEEM-DLKVLQFKNKKLAERLEQRQACEDELRERI 77
E + +RE++ +E +RL + + +V + + ++A QR A E EL+ +
Sbjct: 1528 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA-EAELQSKR 1586
Query: 78 EKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDGTP 137
++ A + +L + AQL E E R + Q E A E +
Sbjct: 1587 ASFAEKTAQLERSLQEEHVAVAQLREEAE---RRAQQQAEAERAREEAEREL-------- 1635
Query: 138 LPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELELQGRMEFSKAAVSRVVE 197
E + + L ++L+ + A EE E E + R + + AV +
Sbjct: 1636 --ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1693
Query: 198 ASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRISLE 257
A L++ QR + G ++ A Q E RL+ Q +++ + E
Sbjct: 1694 AEQELEK------QRQLAEGTAQQRLAAEQ--------ELIRLRAETEQGEQQRQLLEEE 1739
Query: 258 YSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSS 317
+ LQ + +A K E+E ++ K+R + L A A E+ S S
Sbjct: 1740 LARLQREAAAATQKRQELEA-------ELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1792
Query: 318 SGFQGGQITLSMQKFEMLNAELEEN-------QELANSRMAELEKLQAELQGAVRTNERL 370
+ G+ ++ L A EE +E A + AE E++ AE A+ RL
Sbjct: 1793 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1852
Query: 371 KVALRSLPEEVVRETGEYRMLQA----QFSLLYNESLQVKTQLDEARGLLLATKNSHLRH 426
K +E E R L Q L ++ Q K ++E L +S L
Sbjct: 1853 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1912
Query: 427 IEHMESDELGLQKKLRTEVIQL-------------------------EDTLA-------- 453
+ + D L ++++ E++ L EDTL
Sbjct: 1913 QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELE 1972
Query: 454 -----QVRKEYEMLRIEFEQ----NLAANEQAGPINREMRHLISSLQ---NHNHQLKGDA 501
Q+ E E R E E+ +LAA E+A + + L+ +L+ A
Sbjct: 1973 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2032
Query: 502 QRYKRKLREVQAEIGKLRAQASGSAHSTP--------NLGHPEDSGVSAPAPGKEEGGPG 553
++ + ++ E + R QA AH+ ++ V G+ E
Sbjct: 2033 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2092
Query: 554 PVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRE 613
+ + A + + E L S E+ AQ + + R+ +
Sbjct: 2093 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2152
Query: 614 LREREGPSLGPPPVASA--------LSRADREKAKVEET--------------KRKESEL 651
+ E +L A A + R+KA+VE+ K E
Sbjct: 2153 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2212
Query: 652 LKGLRAELKKA--QESQKEMKLLL---------------------------DMYKSAPKE 682
L+ L+AE +A Q SQ E +L D + +E
Sbjct: 2213 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2272
Query: 683 QRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQR 742
+ +K++ +A E + + +R+R+L E D + + +A E L+ QA ++ L
Sbjct: 2273 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA-EKMLKEKMQAVQEATRL-- 2329
Query: 743 KLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKL 802
K E E L + ++ + +QE ++ QQL E+ + +
Sbjct: 2330 -----KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE--------- 2375
Query: 803 LREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRK 862
R+ + E+ + LK +V + EE + + +E+ + EL ++
Sbjct: 2376 -RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ----AEEIGEKLHRTELATQE 2430
Query: 863 AVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRK--LE 920
V Q E + Q +H RLRE L + ++E+ L+ E++ ++++ L+
Sbjct: 2431 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQ 2490
Query: 921 KQRKVE--VYADADEILQEE--IKEYKARL 946
+ + ++ ++ D +LQ E I++ KA+L
Sbjct: 2491 ETQALQQSFLSEKDSLLQRERFIEQEKAKL 2520
Score = 55.8 bits (133), Expect = 2e-07
Identities = 129/664 (19%), Positives = 256/664 (38%), Gaps = 70/664 (10%)
Query: 16 GPPEKKLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNKKLAERLEQRQACEDELRE 75
G E E+ ++ R S + + + L+ ++ A+ Q QA ++LR+
Sbjct: 2085 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2144
Query: 76 RIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDG 135
E+ R+A + L + + +A + H+ E + +A QE T
Sbjct: 2145 EAEQEAARRAQAEQAAL-------RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2197
Query: 136 TPLPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELE----LQGRMEFSKAA 191
L D L +L+ +E A S V++E L+ R+E A
Sbjct: 2198 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2257
Query: 192 VSRVVEASDRLQRRVEELCQRVYSRGDSEP-LSEAAQ--AHTRELGRENRRLQDLATQLQ 248
+ ++ D QR ++E +++ + LS AAQ A R+L E DLA Q
Sbjct: 2258 L--ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE-----DLAQQRA 2310
Query: 249 EKHHRISLEYSELQDKVT-SAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQL 307
+ + +Q+ AE ++L+ + E Q +L++ ++++ + LAE +
Sbjct: 2311 LAEKMLKEKMQAVQEATRLKAEAELLQQQK--ELAQEQARRLQEDKEQMAQQLAEETQGF 2368
Query: 308 NSGYYVSGSSS---GFQGGQITLSMQKFEMLNAELEEN------------QELANSRMAE 352
+ ++ L + + A EE+ ++L + +A
Sbjct: 2369 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2428
Query: 353 LEK------LQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVK 406
EK L+ + Q + ERL+ A+ L E + E ++LQ + + +++Q +
Sbjct: 2429 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM--QTVQQE 2486
Query: 407 TQLDEARGL---LLATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLR 463
L E + L L+ K+S L+ +E ++ L++ + EV + + + +++ + +
Sbjct: 2487 QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2546
Query: 464 IEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQAS 523
E ++ +A+ E+A E + Q QL+ ++ + L E + + + Q
Sbjct: 2547 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL-REQLQLL 2605
Query: 524 GSAHSTPNLGHPEDSGVSAPA-----PGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVK 578
H L H E+ S A P + GP + + G ++ +
Sbjct: 2606 EEQHRAA-LAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQR 2661
Query: 579 KEEL-VPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVASALSRADRE 637
+E + S E+ Q + G R + R + G +A L +A E
Sbjct: 2662 LQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQ---------GRSSIAGLLLKATNE 2712
Query: 638 KAKV 641
K V
Sbjct: 2713 KLSV 2716
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 105 bits (261), Expect = 3e-22
Identities = 207/923 (22%), Positives = 357/923 (38%), Gaps = 152/923 (16%)
Query: 56 NKKLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQ 115
++ + E+L Q QA +E+ EK+E+ Q + + Y QL T +A L
Sbjct: 1241 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL-VTYKAQLE----- 1294
Query: 116 GELSSAPEAPGTQEGPTCDGTPLPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSE 175
++S + P Q G SE + V L SE
Sbjct: 1295 -PVASPAKKPKVQSG----------------------------SESVIQEYVDLRTHYSE 1325
Query: 176 EVELELQGRMEFSKAAVSRVVEASDRL--QRRVEELCQRVYSRGDSEPLSEAAQAHTREL 233
L Q ++F + R+ E +RL Q+R EE + E + A+AH +
Sbjct: 1326 LTTLTSQ-YIKFISETLRRM-EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1383
Query: 234 GRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEM----ETTVEDLQWDIEKL 289
+ R ++L ++QE+ R + Q + S + ++ ++ E ++ E
Sbjct: 1384 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1443
Query: 290 RKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSR 349
+ ++ + + QL + G + G + + L A EE +
Sbjct: 1444 ERSRLRIEEEIRVVRLQLEATERQRGGAEG-----------ELQALRARAEEAEAQKRQA 1492
Query: 350 MAELEKLQAELQGAVRTNERLKVALRSLPE---EVVRETGEYRMLQAQFSLLYNESLQVK 406
E E+L+ ++Q + + +V L S + E RE + R LQA L +
Sbjct: 1493 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE--KQRALQALEEL--------R 1542
Query: 407 TQLDEARGLLLATKNSHLRHIE-----HMESDELGLQKKLRT---EVIQLEDTLAQVRKE 458
Q +EA L + R ++ S E LQ K + + QLE +L +
Sbjct: 1543 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1602
Query: 459 YEMLRIEFEQNLAANEQAGPINREMRHLISSLQ---NHNHQLKGDAQRYKRKLREVQAEI 515
LR E E+ +A E + Q N +L+ A+ ++ QAE
Sbjct: 1603 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1662
Query: 516 GKLRAQASGSAHSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTT 575
K + +A A G E+ V ++E K+ GT
Sbjct: 1663 EKQKEEAEREARRR---GKAEEQAVRQRELAEQE----------LEKQRQLAEGTAQQRL 1709
Query: 576 SVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVASALSRAD 635
+ ++E + E QG +R+L E E L+R
Sbjct: 1710 AAEQELIRLRAETEQG-----------------EQQRQLLEEE------------LARLQ 1740
Query: 636 REKAKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRD----KVQLMA 691
RE A + KR+E L AEL K + EM++LL A +E R Q +
Sbjct: 1741 REAAAATQ-KRQE------LEAELAKVRA---EMEVLLASKARAEEESRSTSEKSKQRLE 1790
Query: 692 AERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGAT---K 748
AE E+ E +R+R L E +R+ +++A+EDA R+ +AE + +G K
Sbjct: 1791 AEAGRFRELAEEAARLRALAEEAKRQ-RQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1849
Query: 749 QEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKD 808
E E L E + + + E ++L E+ + + ER+ Q+ K E +
Sbjct: 1850 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA--QLRKASDSELE 1907
Query: 809 E---LGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTL---RSQALELNKRK 862
L E L + QV+ ++L ++ EK A G E EL L RS A + + K
Sbjct: 1908 RQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELELGRIRSNAEDTLRSK 1962
Query: 863 AVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQ 922
+ A ++ E + R RE + + +S AA E+ + K A E++ RL+ K+E+
Sbjct: 1963 EQAELEAARQRQLAAEE-ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2021
Query: 923 RKVEVYADADEILQEEIKEYKAR 945
R++ A+ + Q ++ + A+
Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQ 2044
Score = 105 bits (261), Expect = 3e-22
Identities = 193/887 (21%), Positives = 363/887 (40%), Gaps = 150/887 (16%)
Query: 177 VELELQGRMEFSKAAV---SRVVEASDRLQRRVEELCQRVY--------SRGDSEPLSEA 225
++ ELQ + S+A + +R EA++R + R+EE + V RG +E +A
Sbjct: 1418 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1477
Query: 226 AQAHTRELGRENRRLQD----LATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTV-- 279
+A E + R+ Q+ L Q+Q++ R EL +V + E + +
Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1537
Query: 280 -EDLQWDIE----KLRKREQKLNKHLAEALE--QLNSGYYVSGSSSGF--QGGQITLSMQ 330
E+L+ E +LR+ E + + + ALE Q ++ + + F + Q+ S+Q
Sbjct: 1538 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1597
Query: 331 KFEMLNAELEENQELANSRMAELEKLQAELQGAV-----RTNERLKVALRSLPEEVVRET 385
+ + A+L E E + AE E+ + E + + + NE L++ L++ EEV ++
Sbjct: 1598 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA--EEVAQQK 1655
Query: 386 GEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHLRHIEHMESDELGLQK------ 439
+ QA+ E+ + + +A + + + +E G +
Sbjct: 1656 S---LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1712
Query: 440 ----KLRTEVIQ-------LEDTLAQVRKEYEML---RIEFEQNLAANEQAGPINREMRH 485
+LR E Q LE+ LA++++E R E E LA + EM
Sbjct: 1713 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK------VRAEMEV 1766
Query: 486 LISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPAP 545
L++S + + +++ K++L +AE G+ R A +A L +
Sbjct: 1767 LLASKARAEEESRSTSEKSKQRL---EAEAGRFRELAEEAAR----LRALAEEAKRQRQL 1819
Query: 546 GKEEGGPGPVSTPDNRKEMAPVPGTTT---TTTSVKKEELVPSEEDFQGITPGAQGPSSR 602
+E+ E G T T + +E E + + R
Sbjct: 1820 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1879
Query: 603 GREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEET---KRKESELLKGLRAEL 659
E A+ K ++ ER L AS S +R+K VE+T +R+ E + L+A
Sbjct: 1880 LEEQAAQHKADIEER----LAQLRKASD-SELERQKGLVEDTLRQRRQVEEEILALKASF 1934
Query: 660 KKAQESQKEMKLLLDMYKSAPKE---QRDKVQLMAAERKAKAEVDELRSRIRELEERDRR 716
+KA + E++L L +S ++ +++ +L AA ++ A +E R R E +R
Sbjct: 1935 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR----EAEERV 1990
Query: 717 ESKKIADEDALRRIRQAEEQIEHLQRKLGATKQ--------------------------E 750
+ A+E+A R+ + A E++E L+ K+ ++ E
Sbjct: 1991 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2050
Query: 751 EEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSE----RIKANQIHKLLREE 806
E+A + Q + +Q +L QLR + +A + E R++A + R +
Sbjct: 2051 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2110
Query: 807 KDEL------GEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNK 860
+E E+ ++Q A ++K E+E A + E+ + QA +
Sbjct: 2111 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ---AEQAALRQKQAADAEM 2167
Query: 861 RKAVEAAQLAEDLKVQLEHVQTRLR---------------EIQPCLAES------RAARE 899
K + A+ K Q+E T LR E+Q AE+ R+ E
Sbjct: 2168 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2227
Query: 900 KESFNLKRAQEDISRLRRKLEKQRKVEVYADAD---EILQEEIKEYK 943
+E F+++ E++S+L+ ++E + + + D D LQEE ++ K
Sbjct: 2228 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2274
Score = 78.6 bits (192), Expect = 3e-14
Identities = 163/822 (19%), Positives = 326/822 (39%), Gaps = 105/822 (12%)
Query: 152 MQLRPPLSEPALAFVVALGASSSEEVELELQ-GRM--------------EFSKAAVSRVV 196
++ R + E LA + +++ + ELEL+ GR+ E A ++
Sbjct: 1917 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1976
Query: 197 EASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGR------ENRRLQDLATQLQEK 250
+R +R EE Q+ S E + +A E+ R E RRL++ A Q +
Sbjct: 1977 AEEERRRREAEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2034
Query: 251 HHRISLE------YSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEAL 304
+++ E +E + + + K E++ T++ Q +++LR + + EA
Sbjct: 2035 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2094
Query: 305 EQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAEL-QGA 363
E + + + Q +++ E L EE + A EKL+ E Q A
Sbjct: 2095 E--------ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2146
Query: 364 VRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSH 423
R + + ALR ++ + M + ++L+ K Q+++ L T
Sbjct: 2147 ARRAQAEQAALRQ------KQAADAEM--EKHKKFAEQTLRQKAQVEQE----LTTLRLQ 2194
Query: 424 LRHIEHMES---DELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPIN 480
L +H ++ +EL ++L+ E + +QV +E +R++ E+ ++ I
Sbjct: 2195 LEETDHQKNLLDEEL---QRLKAEATEAARQRSQVEEELFSVRVQMEE---LSKLKARIE 2248
Query: 481 REMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGV 540
E R LI + K + QR+ ++ E ++ + A+ S +A L + +
Sbjct: 2249 AENRALIL-------RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2301
Query: 541 SAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPG-AQGP 599
+ E+ + + + +E+ +ED + + A+
Sbjct: 2302 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2361
Query: 600 SSRGREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAEL 659
R EA +R+L + A+R K +V E R ++ + +
Sbjct: 2362 QGFQRTLEAERQRQLEMS--------------AEAERLKLRVAEMSRAQARAEEDAQRFR 2407
Query: 660 KKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERK-AKAEVDELRSRIRELEERDRRES 718
K+A+E ++ L + A +E+ VQ + +R+ + + + LR I ELE RE
Sbjct: 2408 KQAEEIGEK----LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE----REK 2459
Query: 719 KKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQ 778
+K+ E L +++ E Q ++ L T+ +++ LSE D Q ++++ +L Q
Sbjct: 2460 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2519
Query: 779 LREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERAL 838
++ E KA Q+ + + ++ ++ ++ L + ++ + EE R
Sbjct: 2520 FQD----------EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2569
Query: 839 QGSLGGVEKELTLRSQALELNKRKAVEAAQLAED----LKVQLEHVQTRLREIQPCLAES 894
Q L +E++ + + L ++ E QL E+ E V L
Sbjct: 2570 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2629
Query: 895 RAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQ 936
R A + + + + LRRK+ QR E + E LQ
Sbjct: 2630 RDALDGPAAEAE-PEHSFDGLRRKVSAQRLQEAGILSAEELQ 2670
Score = 76.3 bits (186), Expect = 1e-13
Identities = 154/802 (19%), Positives = 309/802 (38%), Gaps = 97/802 (12%)
Query: 19 EKKLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNKKLAERLEQRQACEDELRERIE 78
+K L+ EE+ R + E + KV + + +L ER EQ A + +L + E
Sbjct: 1991 QKSLAAEEEAARQ-----RKAALEEVERLKAKVEEAR--RLRERAEQESARQLQLAQ--E 2041
Query: 79 KLEKR-QATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDGTP 137
+KR QA + A V + +L +T+ Q E S + G E
Sbjct: 2042 AAQKRLQAEEKAHAFAVQQKEQELQQTL---------QQEQSVLDQLRGEAEAARRAAEE 2092
Query: 138 LPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELELQGRMEFSKAAVSRVVE 197
E R+ Q R + E L S+ E+ + Q + K E
Sbjct: 2093 AEEARVQAEREAA--QSRRQVEEAE-----RLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2145
Query: 198 ASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRISLE 257
A+ R Q L Q+ + + E + A+ R+ + + L L QL+E H+ +L
Sbjct: 2146 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2205
Query: 258 YSELQDKVTSAETKVLEMETTVEDLQW-------DIEKLRKREQKLNKHLAEALEQLNSG 310
ELQ ++ + T+ + VE+ + ++ KL+ R + N+ L ++ N+
Sbjct: 2206 DEELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI-LRDKDNTQ 2263
Query: 311 YYVSGSSSGF-----QGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVR 365
++ + + +++++ Q+ L EE +LA R A EK+ E AV+
Sbjct: 2264 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE--DLAQQR-ALAEKMLKEKMQAVQ 2320
Query: 366 TNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQL-DEARGLLLATKNSHL 424
RLK L + + + Q Q L + Q+ QL +E +G +
Sbjct: 2321 EATRLKAEAELLQQ-------QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373
Query: 425 RHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMR 484
R +E E +L+ V ++ A+ ++ + R + E+ + +E
Sbjct: 2374 RQLEMSAEAE-----RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2428
Query: 485 HLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPA 544
L+ +L+ Q DA+R + + E++ E KL+ +A + + + +
Sbjct: 2429 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET 2488
Query: 545 PGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGR 604
++ + R+ ++E E+ FQ AQ + R
Sbjct: 2489 QALQQSFLSEKDSLLQRERFI-------------EQEKAKLEQLFQDEVAKAQ----QLR 2531
Query: 605 EPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAELKKAQE 664
E + R ++++ + R A +EE +R++ E +G+R + ++ Q+
Sbjct: 2532 EEQQRQQQQMEQER----------------QRLVASMEEARRRQHEAEEGVRRKQEELQQ 2575
Query: 665 SQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADE 724
+++ + ++ + R+++QL+ + +A E + + + + D
Sbjct: 2576 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDG 2635
Query: 725 DALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDD 784
A + E + L+RK+ A + +E +LS ++ A Q + +L ++D
Sbjct: 2636 PAAE--AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA------QGHTTVDELARRED 2687
Query: 785 ANFKLMSERIKANQIHKLLREE 806
L A + K E+
Sbjct: 2688 VRHYLQGRSSIAGLLLKATNEK 2709
Score = 74.7 bits (182), Expect = 4e-13
Identities = 209/1050 (19%), Positives = 386/1050 (36%), Gaps = 179/1050 (17%)
Query: 19 EKKLSREEKTTTTLIEPIRLGGISSTEEM-DLKVLQFKNKKLAERLEQRQACEDELRERI 77
E + +RE++ +E +RL + + +V + + ++A QR A E EL+ +
Sbjct: 1524 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA-EAELQSKR 1582
Query: 78 EKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDGTP 137
++ A + +L + AQL E E R + Q E A E +
Sbjct: 1583 ASFAEKTAQLERSLQEEHVAVAQLREEAE---RRAQQQAEAERAREEAEREL-------- 1631
Query: 138 LPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELELQGRMEFSKAAVSRVVE 197
E + + L ++L+ + A EE E E + R + + AV +
Sbjct: 1632 --ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1689
Query: 198 ASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRISLE 257
A L++ QR + G ++ A Q E RL+ Q +++ + E
Sbjct: 1690 AEQELEK------QRQLAEGTAQQRLAAEQ--------ELIRLRAETEQGEQQRQLLEEE 1735
Query: 258 YSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSS 317
+ LQ + +A K E+E ++ K+R + L A A E+ S S
Sbjct: 1736 LARLQREAAAATQKRQELEA-------ELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1788
Query: 318 SGFQGGQITLSMQKFEMLNAELEEN-------QELANSRMAELEKLQAELQGAVRTNERL 370
+ G+ ++ L A EE +E A + AE E++ AE A+ RL
Sbjct: 1789 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1848
Query: 371 KVALRSLPEEVVRETGEYRMLQA----QFSLLYNESLQVKTQLDEARGLLLATKNSHLRH 426
K +E E R L Q L ++ Q K ++E L +S L
Sbjct: 1849 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1908
Query: 427 IEHMESDELGLQKKLRTEVIQL-------------------------EDTLA-------- 453
+ + D L ++++ E++ L EDTL
Sbjct: 1909 QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELE 1968
Query: 454 -----QVRKEYEMLRIEFEQ----NLAANEQAGPINREMRHLISSLQ---NHNHQLKGDA 501
Q+ E E R E E+ +LAA E+A + + L+ +L+ A
Sbjct: 1969 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2028
Query: 502 QRYKRKLREVQAEIGKLRAQASGSAHSTP--------NLGHPEDSGVSAPAPGKEEGGPG 553
++ + ++ E + R QA AH+ ++ V G+ E
Sbjct: 2029 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2088
Query: 554 PVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRE 613
+ + A + + E L S E+ AQ + + R+ +
Sbjct: 2089 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2148
Query: 614 LREREGPSLGPPPVASA--------LSRADREKAKVEET--------------KRKESEL 651
+ E +L A A + R+KA+VE+ K E
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2208
Query: 652 LKGLRAELKKA--QESQKEMKLLL---------------------------DMYKSAPKE 682
L+ L+AE +A Q SQ E +L D + +E
Sbjct: 2209 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2268
Query: 683 QRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQR 742
+ +K++ +A E + + +R+R+L E D + + +A E L+ QA ++ L
Sbjct: 2269 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA-EKMLKEKMQAVQEATRL-- 2325
Query: 743 KLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKL 802
K E E L + ++ + +QE ++ QQL E+ + +
Sbjct: 2326 -----KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE--------- 2371
Query: 803 LREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRK 862
R+ + E+ + LK +V + EE + + +E+ + EL ++
Sbjct: 2372 -RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ----AEEIGEKLHRTELATQE 2426
Query: 863 AVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRK--LE 920
V Q E + Q +H RLRE L + ++E+ L+ E++ ++++ L+
Sbjct: 2427 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQ 2486
Query: 921 KQRKVE--VYADADEILQEE--IKEYKARL 946
+ + ++ ++ D +LQ E I++ KA+L
Sbjct: 2487 ETQALQQSFLSEKDSLLQRERFIEQEKAKL 2516
Score = 55.8 bits (133), Expect = 2e-07
Identities = 129/664 (19%), Positives = 256/664 (38%), Gaps = 70/664 (10%)
Query: 16 GPPEKKLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNKKLAERLEQRQACEDELRE 75
G E E+ ++ R S + + + L+ ++ A+ Q QA ++LR+
Sbjct: 2081 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2140
Query: 76 RIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDG 135
E+ R+A + L + + +A + H+ E + +A QE T
Sbjct: 2141 EAEQEAARRAQAEQAAL-------RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2193
Query: 136 TPLPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELE----LQGRMEFSKAA 191
L D L +L+ +E A S V++E L+ R+E A
Sbjct: 2194 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2253
Query: 192 VSRVVEASDRLQRRVEELCQRVYSRGDSEP-LSEAAQ--AHTRELGRENRRLQDLATQLQ 248
+ ++ D QR ++E +++ + LS AAQ A R+L E DLA Q
Sbjct: 2254 L--ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE-----DLAQQRA 2306
Query: 249 EKHHRISLEYSELQDKVT-SAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQL 307
+ + +Q+ AE ++L+ + E Q +L++ ++++ + LAE +
Sbjct: 2307 LAEKMLKEKMQAVQEATRLKAEAELLQQQK--ELAQEQARRLQEDKEQMAQQLAEETQGF 2364
Query: 308 NSGYYVSGSSS---GFQGGQITLSMQKFEMLNAELEEN------------QELANSRMAE 352
+ ++ L + + A EE+ ++L + +A
Sbjct: 2365 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2424
Query: 353 LEK------LQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVK 406
EK L+ + Q + ERL+ A+ L E + E ++LQ + + +++Q +
Sbjct: 2425 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM--QTVQQE 2482
Query: 407 TQLDEARGL---LLATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLR 463
L E + L L+ K+S L+ +E ++ L++ + EV + + + +++ + +
Sbjct: 2483 QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2542
Query: 464 IEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQAS 523
E ++ +A+ E+A E + Q QL+ ++ + L E + + + Q
Sbjct: 2543 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL-REQLQLL 2601
Query: 524 GSAHSTPNLGHPEDSGVSAPA-----PGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVK 578
H L H E+ S A P + GP + + G ++ +
Sbjct: 2602 EEQHRAA-LAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQR 2657
Query: 579 KEEL-VPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVASALSRADRE 637
+E + S E+ Q + G R + R + G +A L +A E
Sbjct: 2658 LQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQ---------GRSSIAGLLLKATNE 2708
Query: 638 KAKV 641
K V
Sbjct: 2709 KLSV 2712
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 105 bits (261), Expect = 3e-22
Identities = 207/923 (22%), Positives = 357/923 (38%), Gaps = 152/923 (16%)
Query: 56 NKKLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQ 115
++ + E+L Q QA +E+ EK+E+ Q + + Y QL T +A L
Sbjct: 1209 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL-VTYKAQLE----- 1262
Query: 116 GELSSAPEAPGTQEGPTCDGTPLPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSE 175
++S + P Q G SE + V L SE
Sbjct: 1263 -PVASPAKKPKVQSG----------------------------SESVIQEYVDLRTHYSE 1293
Query: 176 EVELELQGRMEFSKAAVSRVVEASDRL--QRRVEELCQRVYSRGDSEPLSEAAQAHTREL 233
L Q ++F + R+ E +RL Q+R EE + E + A+AH +
Sbjct: 1294 LTTLTSQ-YIKFISETLRRM-EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1351
Query: 234 GRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEM----ETTVEDLQWDIEKL 289
+ R ++L ++QE+ R + Q + S + ++ ++ E ++ E
Sbjct: 1352 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1411
Query: 290 RKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSR 349
+ ++ + + QL + G + G + + L A EE +
Sbjct: 1412 ERSRLRIEEEIRVVRLQLEATERQRGGAEG-----------ELQALRARAEEAEAQKRQA 1460
Query: 350 MAELEKLQAELQGAVRTNERLKVALRSLPE---EVVRETGEYRMLQAQFSLLYNESLQVK 406
E E+L+ ++Q + + +V L S + E RE + R LQA L +
Sbjct: 1461 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE--KQRALQALEEL--------R 1510
Query: 407 TQLDEARGLLLATKNSHLRHIE-----HMESDELGLQKKLRT---EVIQLEDTLAQVRKE 458
Q +EA L + R ++ S E LQ K + + QLE +L +
Sbjct: 1511 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1570
Query: 459 YEMLRIEFEQNLAANEQAGPINREMRHLISSLQ---NHNHQLKGDAQRYKRKLREVQAEI 515
LR E E+ +A E + Q N +L+ A+ ++ QAE
Sbjct: 1571 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1630
Query: 516 GKLRAQASGSAHSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTT 575
K + +A A G E+ V ++E K+ GT
Sbjct: 1631 EKQKEEAEREARRR---GKAEEQAVRQRELAEQE----------LEKQRQLAEGTAQQRL 1677
Query: 576 SVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVASALSRAD 635
+ ++E + E QG +R+L E E L+R
Sbjct: 1678 AAEQELIRLRAETEQG-----------------EQQRQLLEEE------------LARLQ 1708
Query: 636 REKAKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRD----KVQLMA 691
RE A + KR+E L AEL K + EM++LL A +E R Q +
Sbjct: 1709 REAAAATQ-KRQE------LEAELAKVRA---EMEVLLASKARAEEESRSTSEKSKQRLE 1758
Query: 692 AERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGAT---K 748
AE E+ E +R+R L E +R+ +++A+EDA R+ +AE + +G K
Sbjct: 1759 AEAGRFRELAEEAARLRALAEEAKRQ-RQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1817
Query: 749 QEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKD 808
E E L E + + + E ++L E+ + + ER+ Q+ K E +
Sbjct: 1818 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA--QLRKASDSELE 1875
Query: 809 E---LGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTL---RSQALELNKRK 862
L E L + QV+ ++L ++ EK A G E EL L RS A + + K
Sbjct: 1876 RQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELELGRIRSNAEDTLRSK 1930
Query: 863 AVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQ 922
+ A ++ E + R RE + + +S AA E+ + K A E++ RL+ K+E+
Sbjct: 1931 EQAELEAARQRQLAAEE-ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 1989
Query: 923 RKVEVYADADEILQEEIKEYKAR 945
R++ A+ + Q ++ + A+
Sbjct: 1990 RRLRERAEQESARQLQLAQEAAQ 2012
Score = 105 bits (261), Expect = 3e-22
Identities = 193/887 (21%), Positives = 363/887 (40%), Gaps = 150/887 (16%)
Query: 177 VELELQGRMEFSKAAV---SRVVEASDRLQRRVEELCQRVY--------SRGDSEPLSEA 225
++ ELQ + S+A + +R EA++R + R+EE + V RG +E +A
Sbjct: 1386 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1445
Query: 226 AQAHTRELGRENRRLQD----LATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTV-- 279
+A E + R+ Q+ L Q+Q++ R EL +V + E + +
Sbjct: 1446 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1505
Query: 280 -EDLQWDIE----KLRKREQKLNKHLAEALE--QLNSGYYVSGSSSGF--QGGQITLSMQ 330
E+L+ E +LR+ E + + + ALE Q ++ + + F + Q+ S+Q
Sbjct: 1506 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1565
Query: 331 KFEMLNAELEENQELANSRMAELEKLQAELQGAV-----RTNERLKVALRSLPEEVVRET 385
+ + A+L E E + AE E+ + E + + + NE L++ L++ EEV ++
Sbjct: 1566 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA--EEVAQQK 1623
Query: 386 GEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHLRHIEHMESDELGLQK------ 439
+ QA+ E+ + + +A + + + +E G +
Sbjct: 1624 S---LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1680
Query: 440 ----KLRTEVIQ-------LEDTLAQVRKEYEML---RIEFEQNLAANEQAGPINREMRH 485
+LR E Q LE+ LA++++E R E E LA + EM
Sbjct: 1681 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK------VRAEMEV 1734
Query: 486 LISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPAP 545
L++S + + +++ K++L +AE G+ R A +A L +
Sbjct: 1735 LLASKARAEEESRSTSEKSKQRL---EAEAGRFRELAEEAAR----LRALAEEAKRQRQL 1787
Query: 546 GKEEGGPGPVSTPDNRKEMAPVPGTTT---TTTSVKKEELVPSEEDFQGITPGAQGPSSR 602
+E+ E G T T + +E E + + R
Sbjct: 1788 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1847
Query: 603 GREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEET---KRKESELLKGLRAEL 659
E A+ K ++ ER L AS S +R+K VE+T +R+ E + L+A
Sbjct: 1848 LEEQAAQHKADIEER----LAQLRKASD-SELERQKGLVEDTLRQRRQVEEEILALKASF 1902
Query: 660 KKAQESQKEMKLLLDMYKSAPKE---QRDKVQLMAAERKAKAEVDELRSRIRELEERDRR 716
+KA + E++L L +S ++ +++ +L AA ++ A +E R R E +R
Sbjct: 1903 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR----EAEERV 1958
Query: 717 ESKKIADEDALRRIRQAEEQIEHLQRKLGATKQ--------------------------E 750
+ A+E+A R+ + A E++E L+ K+ ++ E
Sbjct: 1959 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2018
Query: 751 EEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSE----RIKANQIHKLLREE 806
E+A + Q + +Q +L QLR + +A + E R++A + R +
Sbjct: 2019 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2078
Query: 807 KDEL------GEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNK 860
+E E+ ++Q A ++K E+E A + E+ + QA +
Sbjct: 2079 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ---AEQAALRQKQAADAEM 2135
Query: 861 RKAVEAAQLAEDLKVQLEHVQTRLR---------------EIQPCLAES------RAARE 899
K + A+ K Q+E T LR E+Q AE+ R+ E
Sbjct: 2136 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2195
Query: 900 KESFNLKRAQEDISRLRRKLEKQRKVEVYADAD---EILQEEIKEYK 943
+E F+++ E++S+L+ ++E + + + D D LQEE ++ K
Sbjct: 2196 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2242
Score = 78.6 bits (192), Expect = 3e-14
Identities = 163/822 (19%), Positives = 326/822 (39%), Gaps = 105/822 (12%)
Query: 152 MQLRPPLSEPALAFVVALGASSSEEVELELQ-GRM--------------EFSKAAVSRVV 196
++ R + E LA + +++ + ELEL+ GR+ E A ++
Sbjct: 1885 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1944
Query: 197 EASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGR------ENRRLQDLATQLQEK 250
+R +R EE Q+ S E + +A E+ R E RRL++ A Q +
Sbjct: 1945 AEEERRRREAEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2002
Query: 251 HHRISLE------YSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEAL 304
+++ E +E + + + K E++ T++ Q +++LR + + EA
Sbjct: 2003 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2062
Query: 305 EQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAEL-QGA 363
E + + + Q +++ E L EE + A EKL+ E Q A
Sbjct: 2063 E--------ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2114
Query: 364 VRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSH 423
R + + ALR ++ + M + ++L+ K Q+++ L T
Sbjct: 2115 ARRAQAEQAALRQ------KQAADAEM--EKHKKFAEQTLRQKAQVEQE----LTTLRLQ 2162
Query: 424 LRHIEHMES---DELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPIN 480
L +H ++ +EL ++L+ E + +QV +E +R++ E+ ++ I
Sbjct: 2163 LEETDHQKNLLDEEL---QRLKAEATEAARQRSQVEEELFSVRVQMEE---LSKLKARIE 2216
Query: 481 REMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGV 540
E R LI + K + QR+ ++ E ++ + A+ S +A L + +
Sbjct: 2217 AENRALIL-------RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2269
Query: 541 SAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPG-AQGP 599
+ E+ + + + +E+ +ED + + A+
Sbjct: 2270 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2329
Query: 600 SSRGREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAEL 659
R EA +R+L + A+R K +V E R ++ + +
Sbjct: 2330 QGFQRTLEAERQRQLEMS--------------AEAERLKLRVAEMSRAQARAEEDAQRFR 2375
Query: 660 KKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERK-AKAEVDELRSRIRELEERDRRES 718
K+A+E ++ L + A +E+ VQ + +R+ + + + LR I ELE RE
Sbjct: 2376 KQAEEIGEK----LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE----REK 2427
Query: 719 KKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQ 778
+K+ E L +++ E Q ++ L T+ +++ LSE D Q ++++ +L Q
Sbjct: 2428 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2487
Query: 779 LREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERAL 838
++ E KA Q+ + + ++ ++ ++ L + ++ + EE R
Sbjct: 2488 FQD----------EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2537
Query: 839 QGSLGGVEKELTLRSQALELNKRKAVEAAQLAED----LKVQLEHVQTRLREIQPCLAES 894
Q L +E++ + + L ++ E QL E+ E V L
Sbjct: 2538 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2597
Query: 895 RAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQ 936
R A + + + + LRRK+ QR E + E LQ
Sbjct: 2598 RDALDGPAAEAE-PEHSFDGLRRKVSAQRLQEAGILSAEELQ 2638
Score = 76.3 bits (186), Expect = 1e-13
Identities = 154/802 (19%), Positives = 309/802 (38%), Gaps = 97/802 (12%)
Query: 19 EKKLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNKKLAERLEQRQACEDELRERIE 78
+K L+ EE+ R + E + KV + + +L ER EQ A + +L + E
Sbjct: 1959 QKSLAAEEEAARQ-----RKAALEEVERLKAKVEEAR--RLRERAEQESARQLQLAQ--E 2009
Query: 79 KLEKR-QATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDGTP 137
+KR QA + A V + +L +T+ Q E S + G E
Sbjct: 2010 AAQKRLQAEEKAHAFAVQQKEQELQQTL---------QQEQSVLDQLRGEAEAARRAAEE 2060
Query: 138 LPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELELQGRMEFSKAAVSRVVE 197
E R+ Q R + E L S+ E+ + Q + K E
Sbjct: 2061 AEEARVQAEREAA--QSRRQVEEAE-----RLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2113
Query: 198 ASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRISLE 257
A+ R Q L Q+ + + E + A+ R+ + + L L QL+E H+ +L
Sbjct: 2114 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2173
Query: 258 YSELQDKVTSAETKVLEMETTVEDLQW-------DIEKLRKREQKLNKHLAEALEQLNSG 310
ELQ ++ + T+ + VE+ + ++ KL+ R + N+ L ++ N+
Sbjct: 2174 DEELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI-LRDKDNTQ 2231
Query: 311 YYVSGSSSGF-----QGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVR 365
++ + + +++++ Q+ L EE +LA R A EK+ E AV+
Sbjct: 2232 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE--DLAQQR-ALAEKMLKEKMQAVQ 2288
Query: 366 TNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQL-DEARGLLLATKNSHL 424
RLK L + + + Q Q L + Q+ QL +E +G +
Sbjct: 2289 EATRLKAEAELLQQ-------QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2341
Query: 425 RHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMR 484
R +E E +L+ V ++ A+ ++ + R + E+ + +E
Sbjct: 2342 RQLEMSAEAE-----RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2396
Query: 485 HLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPA 544
L+ +L+ Q DA+R + + E++ E KL+ +A + + + +
Sbjct: 2397 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET 2456
Query: 545 PGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGR 604
++ + R+ ++E E+ FQ AQ + R
Sbjct: 2457 QALQQSFLSEKDSLLQRERFI-------------EQEKAKLEQLFQDEVAKAQ----QLR 2499
Query: 605 EPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAELKKAQE 664
E + R ++++ + R A +EE +R++ E +G+R + ++ Q+
Sbjct: 2500 EEQQRQQQQMEQER----------------QRLVASMEEARRRQHEAEEGVRRKQEELQQ 2543
Query: 665 SQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADE 724
+++ + ++ + R+++QL+ + +A E + + + + D
Sbjct: 2544 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDG 2603
Query: 725 DALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDD 784
A + E + L+RK+ A + +E +LS ++ A Q + +L ++D
Sbjct: 2604 PAAE--AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA------QGHTTVDELARRED 2655
Query: 785 ANFKLMSERIKANQIHKLLREE 806
L A + K E+
Sbjct: 2656 VRHYLQGRSSIAGLLLKATNEK 2677
Score = 74.7 bits (182), Expect = 4e-13
Identities = 209/1050 (19%), Positives = 386/1050 (36%), Gaps = 179/1050 (17%)
Query: 19 EKKLSREEKTTTTLIEPIRLGGISSTEEM-DLKVLQFKNKKLAERLEQRQACEDELRERI 77
E + +RE++ +E +RL + + +V + + ++A QR A E EL+ +
Sbjct: 1492 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA-EAELQSKR 1550
Query: 78 EKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDGTP 137
++ A + +L + AQL E E R + Q E A E +
Sbjct: 1551 ASFAEKTAQLERSLQEEHVAVAQLREEAE---RRAQQQAEAERAREEAEREL-------- 1599
Query: 138 LPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELELQGRMEFSKAAVSRVVE 197
E + + L ++L+ + A EE E E + R + + AV +
Sbjct: 1600 --ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1657
Query: 198 ASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRISLE 257
A L++ QR + G ++ A Q E RL+ Q +++ + E
Sbjct: 1658 AEQELEK------QRQLAEGTAQQRLAAEQ--------ELIRLRAETEQGEQQRQLLEEE 1703
Query: 258 YSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSS 317
+ LQ + +A K E+E ++ K+R + L A A E+ S S
Sbjct: 1704 LARLQREAAAATQKRQELEA-------ELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1756
Query: 318 SGFQGGQITLSMQKFEMLNAELEEN-------QELANSRMAELEKLQAELQGAVRTNERL 370
+ G+ ++ L A EE +E A + AE E++ AE A+ RL
Sbjct: 1757 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1816
Query: 371 KVALRSLPEEVVRETGEYRMLQA----QFSLLYNESLQVKTQLDEARGLLLATKNSHLRH 426
K +E E R L Q L ++ Q K ++E L +S L
Sbjct: 1817 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1876
Query: 427 IEHMESDELGLQKKLRTEVIQL-------------------------EDTLA-------- 453
+ + D L ++++ E++ L EDTL
Sbjct: 1877 QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELE 1936
Query: 454 -----QVRKEYEMLRIEFEQ----NLAANEQAGPINREMRHLISSLQ---NHNHQLKGDA 501
Q+ E E R E E+ +LAA E+A + + L+ +L+ A
Sbjct: 1937 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 1996
Query: 502 QRYKRKLREVQAEIGKLRAQASGSAHSTP--------NLGHPEDSGVSAPAPGKEEGGPG 553
++ + ++ E + R QA AH+ ++ V G+ E
Sbjct: 1997 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2056
Query: 554 PVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRE 613
+ + A + + E L S E+ AQ + + R+ +
Sbjct: 2057 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2116
Query: 614 LREREGPSLGPPPVASA--------LSRADREKAKVEET--------------KRKESEL 651
+ E +L A A + R+KA+VE+ K E
Sbjct: 2117 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2176
Query: 652 LKGLRAELKKA--QESQKEMKLLL---------------------------DMYKSAPKE 682
L+ L+AE +A Q SQ E +L D + +E
Sbjct: 2177 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2236
Query: 683 QRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQR 742
+ +K++ +A E + + +R+R+L E D + + +A E L+ QA ++ L
Sbjct: 2237 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA-EKMLKEKMQAVQEATRL-- 2293
Query: 743 KLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKL 802
K E E L + ++ + +QE ++ QQL E+ + +
Sbjct: 2294 -----KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE--------- 2339
Query: 803 LREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRK 862
R+ + E+ + LK +V + EE + + +E+ + EL ++
Sbjct: 2340 -RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ----AEEIGEKLHRTELATQE 2394
Query: 863 AVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRK--LE 920
V Q E + Q +H RLRE L + ++E+ L+ E++ ++++ L+
Sbjct: 2395 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQ 2454
Query: 921 KQRKVE--VYADADEILQEE--IKEYKARL 946
+ + ++ ++ D +LQ E I++ KA+L
Sbjct: 2455 ETQALQQSFLSEKDSLLQRERFIEQEKAKL 2484
Score = 55.8 bits (133), Expect = 2e-07
Identities = 129/664 (19%), Positives = 256/664 (38%), Gaps = 70/664 (10%)
Query: 16 GPPEKKLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNKKLAERLEQRQACEDELRE 75
G E E+ ++ R S + + + L+ ++ A+ Q QA ++LR+
Sbjct: 2049 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2108
Query: 76 RIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDG 135
E+ R+A + L + + +A + H+ E + +A QE T
Sbjct: 2109 EAEQEAARRAQAEQAAL-------RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2161
Query: 136 TPLPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELE----LQGRMEFSKAA 191
L D L +L+ +E A S V++E L+ R+E A
Sbjct: 2162 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2221
Query: 192 VSRVVEASDRLQRRVEELCQRVYSRGDSEP-LSEAAQ--AHTRELGRENRRLQDLATQLQ 248
+ ++ D QR ++E +++ + LS AAQ A R+L E DLA Q
Sbjct: 2222 L--ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE-----DLAQQRA 2274
Query: 249 EKHHRISLEYSELQDKVT-SAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQL 307
+ + +Q+ AE ++L+ + E Q +L++ ++++ + LAE +
Sbjct: 2275 LAEKMLKEKMQAVQEATRLKAEAELLQQQK--ELAQEQARRLQEDKEQMAQQLAEETQGF 2332
Query: 308 NSGYYVSGSSS---GFQGGQITLSMQKFEMLNAELEEN------------QELANSRMAE 352
+ ++ L + + A EE+ ++L + +A
Sbjct: 2333 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2392
Query: 353 LEK------LQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVK 406
EK L+ + Q + ERL+ A+ L E + E ++LQ + + +++Q +
Sbjct: 2393 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM--QTVQQE 2450
Query: 407 TQLDEARGL---LLATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLR 463
L E + L L+ K+S L+ +E ++ L++ + EV + + + +++ + +
Sbjct: 2451 QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2510
Query: 464 IEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQAS 523
E ++ +A+ E+A E + Q QL+ ++ + L E + + + Q
Sbjct: 2511 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL-REQLQLL 2569
Query: 524 GSAHSTPNLGHPEDSGVSAPA-----PGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVK 578
H L H E+ S A P + GP + + G ++ +
Sbjct: 2570 EEQHRAA-LAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQR 2625
Query: 579 KEEL-VPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVASALSRADRE 637
+E + S E+ Q + G R + R + G +A L +A E
Sbjct: 2626 LQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQ---------GRSSIAGLLLKATNE 2676
Query: 638 KAKV 641
K V
Sbjct: 2677 KLSV 2680
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 105 bits (261), Expect = 3e-22
Identities = 207/923 (22%), Positives = 357/923 (38%), Gaps = 152/923 (16%)
Query: 56 NKKLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQ 115
++ + E+L Q QA +E+ EK+E+ Q + + Y QL T +A L
Sbjct: 1378 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL-VTYKAQLE----- 1431
Query: 116 GELSSAPEAPGTQEGPTCDGTPLPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSE 175
++S + P Q G SE + V L SE
Sbjct: 1432 -PVASPAKKPKVQSG----------------------------SESVIQEYVDLRTHYSE 1462
Query: 176 EVELELQGRMEFSKAAVSRVVEASDRL--QRRVEELCQRVYSRGDSEPLSEAAQAHTREL 233
L Q ++F + R+ E +RL Q+R EE + E + A+AH +
Sbjct: 1463 LTTLTSQ-YIKFISETLRRM-EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1520
Query: 234 GRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEM----ETTVEDLQWDIEKL 289
+ R ++L ++QE+ R + Q + S + ++ ++ E ++ E
Sbjct: 1521 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1580
Query: 290 RKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSR 349
+ ++ + + QL + G + G + + L A EE +
Sbjct: 1581 ERSRLRIEEEIRVVRLQLEATERQRGGAEG-----------ELQALRARAEEAEAQKRQA 1629
Query: 350 MAELEKLQAELQGAVRTNERLKVALRSLPE---EVVRETGEYRMLQAQFSLLYNESLQVK 406
E E+L+ ++Q + + +V L S + E RE + R LQA L +
Sbjct: 1630 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE--KQRALQALEEL--------R 1679
Query: 407 TQLDEARGLLLATKNSHLRHIE-----HMESDELGLQKKLRT---EVIQLEDTLAQVRKE 458
Q +EA L + R ++ S E LQ K + + QLE +L +
Sbjct: 1680 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1739
Query: 459 YEMLRIEFEQNLAANEQAGPINREMRHLISSLQ---NHNHQLKGDAQRYKRKLREVQAEI 515
LR E E+ +A E + Q N +L+ A+ ++ QAE
Sbjct: 1740 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1799
Query: 516 GKLRAQASGSAHSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTT 575
K + +A A G E+ V ++E K+ GT
Sbjct: 1800 EKQKEEAEREARRR---GKAEEQAVRQRELAEQE----------LEKQRQLAEGTAQQRL 1846
Query: 576 SVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVASALSRAD 635
+ ++E + E QG +R+L E E L+R
Sbjct: 1847 AAEQELIRLRAETEQG-----------------EQQRQLLEEE------------LARLQ 1877
Query: 636 REKAKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRD----KVQLMA 691
RE A + KR+E L AEL K + EM++LL A +E R Q +
Sbjct: 1878 REAAAATQ-KRQE------LEAELAKVRA---EMEVLLASKARAEEESRSTSEKSKQRLE 1927
Query: 692 AERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGAT---K 748
AE E+ E +R+R L E +R+ +++A+EDA R+ +AE + +G K
Sbjct: 1928 AEAGRFRELAEEAARLRALAEEAKRQ-RQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1986
Query: 749 QEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKD 808
E E L E + + + E ++L E+ + + ER+ Q+ K E +
Sbjct: 1987 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA--QLRKASDSELE 2044
Query: 809 E---LGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTL---RSQALELNKRK 862
L E L + QV+ ++L ++ EK A G E EL L RS A + + K
Sbjct: 2045 RQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELELGRIRSNAEDTLRSK 2099
Query: 863 AVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQ 922
+ A ++ E + R RE + + +S AA E+ + K A E++ RL+ K+E+
Sbjct: 2100 EQAELEAARQRQLAAEE-ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2158
Query: 923 RKVEVYADADEILQEEIKEYKAR 945
R++ A+ + Q ++ + A+
Sbjct: 2159 RRLRERAEQESARQLQLAQEAAQ 2181
Score = 105 bits (261), Expect = 3e-22
Identities = 193/887 (21%), Positives = 363/887 (40%), Gaps = 150/887 (16%)
Query: 177 VELELQGRMEFSKAAV---SRVVEASDRLQRRVEELCQRVY--------SRGDSEPLSEA 225
++ ELQ + S+A + +R EA++R + R+EE + V RG +E +A
Sbjct: 1555 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1614
Query: 226 AQAHTRELGRENRRLQD----LATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTV-- 279
+A E + R+ Q+ L Q+Q++ R EL +V + E + +
Sbjct: 1615 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1674
Query: 280 -EDLQWDIE----KLRKREQKLNKHLAEALE--QLNSGYYVSGSSSGF--QGGQITLSMQ 330
E+L+ E +LR+ E + + + ALE Q ++ + + F + Q+ S+Q
Sbjct: 1675 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1734
Query: 331 KFEMLNAELEENQELANSRMAELEKLQAELQGAV-----RTNERLKVALRSLPEEVVRET 385
+ + A+L E E + AE E+ + E + + + NE L++ L++ EEV ++
Sbjct: 1735 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA--EEVAQQK 1792
Query: 386 GEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHLRHIEHMESDELGLQK------ 439
+ QA+ E+ + + +A + + + +E G +
Sbjct: 1793 S---LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1849
Query: 440 ----KLRTEVIQ-------LEDTLAQVRKEYEML---RIEFEQNLAANEQAGPINREMRH 485
+LR E Q LE+ LA++++E R E E LA + EM
Sbjct: 1850 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK------VRAEMEV 1903
Query: 486 LISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPAP 545
L++S + + +++ K++L +AE G+ R A +A L +
Sbjct: 1904 LLASKARAEEESRSTSEKSKQRL---EAEAGRFRELAEEAAR----LRALAEEAKRQRQL 1956
Query: 546 GKEEGGPGPVSTPDNRKEMAPVPGTTT---TTTSVKKEELVPSEEDFQGITPGAQGPSSR 602
+E+ E G T T + +E E + + R
Sbjct: 1957 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 2016
Query: 603 GREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEET---KRKESELLKGLRAEL 659
E A+ K ++ ER L AS S +R+K VE+T +R+ E + L+A
Sbjct: 2017 LEEQAAQHKADIEER----LAQLRKASD-SELERQKGLVEDTLRQRRQVEEEILALKASF 2071
Query: 660 KKAQESQKEMKLLLDMYKSAPKE---QRDKVQLMAAERKAKAEVDELRSRIRELEERDRR 716
+KA + E++L L +S ++ +++ +L AA ++ A +E R R E +R
Sbjct: 2072 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR----EAEERV 2127
Query: 717 ESKKIADEDALRRIRQAEEQIEHLQRKLGATKQ--------------------------E 750
+ A+E+A R+ + A E++E L+ K+ ++ E
Sbjct: 2128 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2187
Query: 751 EEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSE----RIKANQIHKLLREE 806
E+A + Q + +Q +L QLR + +A + E R++A + R +
Sbjct: 2188 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2247
Query: 807 KDEL------GEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNK 860
+E E+ ++Q A ++K E+E A + E+ + QA +
Sbjct: 2248 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ---AEQAALRQKQAADAEM 2304
Query: 861 RKAVEAAQLAEDLKVQLEHVQTRLR---------------EIQPCLAES------RAARE 899
K + A+ K Q+E T LR E+Q AE+ R+ E
Sbjct: 2305 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2364
Query: 900 KESFNLKRAQEDISRLRRKLEKQRKVEVYADAD---EILQEEIKEYK 943
+E F+++ E++S+L+ ++E + + + D D LQEE ++ K
Sbjct: 2365 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2411
Score = 78.6 bits (192), Expect = 3e-14
Identities = 163/822 (19%), Positives = 326/822 (39%), Gaps = 105/822 (12%)
Query: 152 MQLRPPLSEPALAFVVALGASSSEEVELELQ-GRM--------------EFSKAAVSRVV 196
++ R + E LA + +++ + ELEL+ GR+ E A ++
Sbjct: 2054 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 2113
Query: 197 EASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGR------ENRRLQDLATQLQEK 250
+R +R EE Q+ S E + +A E+ R E RRL++ A Q +
Sbjct: 2114 AEEERRRREAEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2171
Query: 251 HHRISLE------YSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEAL 304
+++ E +E + + + K E++ T++ Q +++LR + + EA
Sbjct: 2172 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2231
Query: 305 EQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAEL-QGA 363
E + + + Q +++ E L EE + A EKL+ E Q A
Sbjct: 2232 E--------ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2283
Query: 364 VRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSH 423
R + + ALR ++ + M + ++L+ K Q+++ L T
Sbjct: 2284 ARRAQAEQAALRQ------KQAADAEM--EKHKKFAEQTLRQKAQVEQE----LTTLRLQ 2331
Query: 424 LRHIEHMES---DELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPIN 480
L +H ++ +EL ++L+ E + +QV +E +R++ E+ ++ I
Sbjct: 2332 LEETDHQKNLLDEEL---QRLKAEATEAARQRSQVEEELFSVRVQMEE---LSKLKARIE 2385
Query: 481 REMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGV 540
E R LI + K + QR+ ++ E ++ + A+ S +A L + +
Sbjct: 2386 AENRALIL-------RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2438
Query: 541 SAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPG-AQGP 599
+ E+ + + + +E+ +ED + + A+
Sbjct: 2439 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2498
Query: 600 SSRGREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAEL 659
R EA +R+L + A+R K +V E R ++ + +
Sbjct: 2499 QGFQRTLEAERQRQLEMS--------------AEAERLKLRVAEMSRAQARAEEDAQRFR 2544
Query: 660 KKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERK-AKAEVDELRSRIRELEERDRRES 718
K+A+E ++ L + A +E+ VQ + +R+ + + + LR I ELE RE
Sbjct: 2545 KQAEEIGEK----LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE----REK 2596
Query: 719 KKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQ 778
+K+ E L +++ E Q ++ L T+ +++ LSE D Q ++++ +L Q
Sbjct: 2597 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2656
Query: 779 LREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERAL 838
++ E KA Q+ + + ++ ++ ++ L + ++ + EE R
Sbjct: 2657 FQD----------EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2706
Query: 839 QGSLGGVEKELTLRSQALELNKRKAVEAAQLAED----LKVQLEHVQTRLREIQPCLAES 894
Q L +E++ + + L ++ E QL E+ E V L
Sbjct: 2707 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2766
Query: 895 RAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQ 936
R A + + + + LRRK+ QR E + E LQ
Sbjct: 2767 RDALDGPAAEAE-PEHSFDGLRRKVSAQRLQEAGILSAEELQ 2807
Score = 76.3 bits (186), Expect = 1e-13
Identities = 154/802 (19%), Positives = 309/802 (38%), Gaps = 97/802 (12%)
Query: 19 EKKLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNKKLAERLEQRQACEDELRERIE 78
+K L+ EE+ R + E + KV + + +L ER EQ A + +L + E
Sbjct: 2128 QKSLAAEEEAARQ-----RKAALEEVERLKAKVEEAR--RLRERAEQESARQLQLAQ--E 2178
Query: 79 KLEKR-QATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDGTP 137
+KR QA + A V + +L +T+ Q E S + G E
Sbjct: 2179 AAQKRLQAEEKAHAFAVQQKEQELQQTL---------QQEQSVLDQLRGEAEAARRAAEE 2229
Query: 138 LPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELELQGRMEFSKAAVSRVVE 197
E R+ Q R + E L S+ E+ + Q + K E
Sbjct: 2230 AEEARVQAEREAA--QSRRQVEEAE-----RLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2282
Query: 198 ASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRISLE 257
A+ R Q L Q+ + + E + A+ R+ + + L L QL+E H+ +L
Sbjct: 2283 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2342
Query: 258 YSELQDKVTSAETKVLEMETTVEDLQW-------DIEKLRKREQKLNKHLAEALEQLNSG 310
ELQ ++ + T+ + VE+ + ++ KL+ R + N+ L ++ N+
Sbjct: 2343 DEELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI-LRDKDNTQ 2400
Query: 311 YYVSGSSSGF-----QGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVR 365
++ + + +++++ Q+ L EE +LA R A EK+ E AV+
Sbjct: 2401 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE--DLAQQR-ALAEKMLKEKMQAVQ 2457
Query: 366 TNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQL-DEARGLLLATKNSHL 424
RLK L + + + Q Q L + Q+ QL +E +G +
Sbjct: 2458 EATRLKAEAELLQQ-------QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2510
Query: 425 RHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMR 484
R +E E +L+ V ++ A+ ++ + R + E+ + +E
Sbjct: 2511 RQLEMSAEAE-----RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2565
Query: 485 HLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPA 544
L+ +L+ Q DA+R + + E++ E KL+ +A + + + +
Sbjct: 2566 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET 2625
Query: 545 PGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGR 604
++ + R+ ++E E+ FQ AQ + R
Sbjct: 2626 QALQQSFLSEKDSLLQRERFI-------------EQEKAKLEQLFQDEVAKAQ----QLR 2668
Query: 605 EPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAELKKAQE 664
E + R ++++ + R A +EE +R++ E +G+R + ++ Q+
Sbjct: 2669 EEQQRQQQQMEQER----------------QRLVASMEEARRRQHEAEEGVRRKQEELQQ 2712
Query: 665 SQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADE 724
+++ + ++ + R+++QL+ + +A E + + + + D
Sbjct: 2713 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDG 2772
Query: 725 DALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDD 784
A + E + L+RK+ A + +E +LS ++ A Q + +L ++D
Sbjct: 2773 PAAE--AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA------QGHTTVDELARRED 2824
Query: 785 ANFKLMSERIKANQIHKLLREE 806
L A + K E+
Sbjct: 2825 VRHYLQGRSSIAGLLLKATNEK 2846
Score = 74.7 bits (182), Expect = 4e-13
Identities = 209/1050 (19%), Positives = 386/1050 (36%), Gaps = 179/1050 (17%)
Query: 19 EKKLSREEKTTTTLIEPIRLGGISSTEEM-DLKVLQFKNKKLAERLEQRQACEDELRERI 77
E + +RE++ +E +RL + + +V + + ++A QR A E EL+ +
Sbjct: 1661 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA-EAELQSKR 1719
Query: 78 EKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDGTP 137
++ A + +L + AQL E E R + Q E A E +
Sbjct: 1720 ASFAEKTAQLERSLQEEHVAVAQLREEAE---RRAQQQAEAERAREEAEREL-------- 1768
Query: 138 LPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELELQGRMEFSKAAVSRVVE 197
E + + L ++L+ + A EE E E + R + + AV +
Sbjct: 1769 --ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1826
Query: 198 ASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRISLE 257
A L++ QR + G ++ A Q E RL+ Q +++ + E
Sbjct: 1827 AEQELEK------QRQLAEGTAQQRLAAEQ--------ELIRLRAETEQGEQQRQLLEEE 1872
Query: 258 YSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSS 317
+ LQ + +A K E+E ++ K+R + L A A E+ S S
Sbjct: 1873 LARLQREAAAATQKRQELEA-------ELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1925
Query: 318 SGFQGGQITLSMQKFEMLNAELEEN-------QELANSRMAELEKLQAELQGAVRTNERL 370
+ G+ ++ L A EE +E A + AE E++ AE A+ RL
Sbjct: 1926 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1985
Query: 371 KVALRSLPEEVVRETGEYRMLQA----QFSLLYNESLQVKTQLDEARGLLLATKNSHLRH 426
K +E E R L Q L ++ Q K ++E L +S L
Sbjct: 1986 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 2045
Query: 427 IEHMESDELGLQKKLRTEVIQL-------------------------EDTLA-------- 453
+ + D L ++++ E++ L EDTL
Sbjct: 2046 QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELE 2105
Query: 454 -----QVRKEYEMLRIEFEQ----NLAANEQAGPINREMRHLISSLQ---NHNHQLKGDA 501
Q+ E E R E E+ +LAA E+A + + L+ +L+ A
Sbjct: 2106 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2165
Query: 502 QRYKRKLREVQAEIGKLRAQASGSAHSTP--------NLGHPEDSGVSAPAPGKEEGGPG 553
++ + ++ E + R QA AH+ ++ V G+ E
Sbjct: 2166 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2225
Query: 554 PVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRE 613
+ + A + + E L S E+ AQ + + R+ +
Sbjct: 2226 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2285
Query: 614 LREREGPSLGPPPVASA--------LSRADREKAKVEET--------------KRKESEL 651
+ E +L A A + R+KA+VE+ K E
Sbjct: 2286 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2345
Query: 652 LKGLRAELKKA--QESQKEMKLLL---------------------------DMYKSAPKE 682
L+ L+AE +A Q SQ E +L D + +E
Sbjct: 2346 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2405
Query: 683 QRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQR 742
+ +K++ +A E + + +R+R+L E D + + +A E L+ QA ++ L
Sbjct: 2406 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA-EKMLKEKMQAVQEATRL-- 2462
Query: 743 KLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKL 802
K E E L + ++ + +QE ++ QQL E+ + +
Sbjct: 2463 -----KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE--------- 2508
Query: 803 LREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRK 862
R+ + E+ + LK +V + EE + + +E+ + EL ++
Sbjct: 2509 -RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ----AEEIGEKLHRTELATQE 2563
Query: 863 AVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRK--LE 920
V Q E + Q +H RLRE L + ++E+ L+ E++ ++++ L+
Sbjct: 2564 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQ 2623
Query: 921 KQRKVE--VYADADEILQEE--IKEYKARL 946
+ + ++ ++ D +LQ E I++ KA+L
Sbjct: 2624 ETQALQQSFLSEKDSLLQRERFIEQEKAKL 2653
Score = 55.8 bits (133), Expect = 2e-07
Identities = 129/664 (19%), Positives = 256/664 (38%), Gaps = 70/664 (10%)
Query: 16 GPPEKKLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNKKLAERLEQRQACEDELRE 75
G E E+ ++ R S + + + L+ ++ A+ Q QA ++LR+
Sbjct: 2218 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2277
Query: 76 RIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDG 135
E+ R+A + L + + +A + H+ E + +A QE T
Sbjct: 2278 EAEQEAARRAQAEQAAL-------RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2330
Query: 136 TPLPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELE----LQGRMEFSKAA 191
L D L +L+ +E A S V++E L+ R+E A
Sbjct: 2331 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2390
Query: 192 VSRVVEASDRLQRRVEELCQRVYSRGDSEP-LSEAAQ--AHTRELGRENRRLQDLATQLQ 248
+ ++ D QR ++E +++ + LS AAQ A R+L E DLA Q
Sbjct: 2391 L--ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE-----DLAQQRA 2443
Query: 249 EKHHRISLEYSELQDKVT-SAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQL 307
+ + +Q+ AE ++L+ + E Q +L++ ++++ + LAE +
Sbjct: 2444 LAEKMLKEKMQAVQEATRLKAEAELLQQQK--ELAQEQARRLQEDKEQMAQQLAEETQGF 2501
Query: 308 NSGYYVSGSSS---GFQGGQITLSMQKFEMLNAELEEN------------QELANSRMAE 352
+ ++ L + + A EE+ ++L + +A
Sbjct: 2502 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2561
Query: 353 LEK------LQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVK 406
EK L+ + Q + ERL+ A+ L E + E ++LQ + + +++Q +
Sbjct: 2562 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM--QTVQQE 2619
Query: 407 TQLDEARGL---LLATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLR 463
L E + L L+ K+S L+ +E ++ L++ + EV + + + +++ + +
Sbjct: 2620 QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2679
Query: 464 IEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQAS 523
E ++ +A+ E+A E + Q QL+ ++ + L E + + + Q
Sbjct: 2680 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL-REQLQLL 2738
Query: 524 GSAHSTPNLGHPEDSGVSAPA-----PGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVK 578
H L H E+ S A P + GP + + G ++ +
Sbjct: 2739 EEQHRAA-LAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQR 2794
Query: 579 KEEL-VPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVASALSRADRE 637
+E + S E+ Q + G R + R + G +A L +A E
Sbjct: 2795 LQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQ---------GRSSIAGLLLKATNE 2845
Query: 638 KAKV 641
K V
Sbjct: 2846 KLSV 2849
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 105 bits (261), Expect = 3e-22
Identities = 207/923 (22%), Positives = 357/923 (38%), Gaps = 152/923 (16%)
Query: 56 NKKLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQ 115
++ + E+L Q QA +E+ EK+E+ Q + + Y QL T +A L
Sbjct: 1219 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL-VTYKAQLE----- 1272
Query: 116 GELSSAPEAPGTQEGPTCDGTPLPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSE 175
++S + P Q G SE + V L SE
Sbjct: 1273 -PVASPAKKPKVQSG----------------------------SESVIQEYVDLRTHYSE 1303
Query: 176 EVELELQGRMEFSKAAVSRVVEASDRL--QRRVEELCQRVYSRGDSEPLSEAAQAHTREL 233
L Q ++F + R+ E +RL Q+R EE + E + A+AH +
Sbjct: 1304 LTTLTSQ-YIKFISETLRRM-EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1361
Query: 234 GRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEM----ETTVEDLQWDIEKL 289
+ R ++L ++QE+ R + Q + S + ++ ++ E ++ E
Sbjct: 1362 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1421
Query: 290 RKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSR 349
+ ++ + + QL + G + G + + L A EE +
Sbjct: 1422 ERSRLRIEEEIRVVRLQLEATERQRGGAEG-----------ELQALRARAEEAEAQKRQA 1470
Query: 350 MAELEKLQAELQGAVRTNERLKVALRSLPE---EVVRETGEYRMLQAQFSLLYNESLQVK 406
E E+L+ ++Q + + +V L S + E RE + R LQA L +
Sbjct: 1471 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE--KQRALQALEEL--------R 1520
Query: 407 TQLDEARGLLLATKNSHLRHIE-----HMESDELGLQKKLRT---EVIQLEDTLAQVRKE 458
Q +EA L + R ++ S E LQ K + + QLE +L +
Sbjct: 1521 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1580
Query: 459 YEMLRIEFEQNLAANEQAGPINREMRHLISSLQ---NHNHQLKGDAQRYKRKLREVQAEI 515
LR E E+ +A E + Q N +L+ A+ ++ QAE
Sbjct: 1581 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1640
Query: 516 GKLRAQASGSAHSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTT 575
K + +A A G E+ V ++E K+ GT
Sbjct: 1641 EKQKEEAEREARRR---GKAEEQAVRQRELAEQE----------LEKQRQLAEGTAQQRL 1687
Query: 576 SVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVASALSRAD 635
+ ++E + E QG +R+L E E L+R
Sbjct: 1688 AAEQELIRLRAETEQG-----------------EQQRQLLEEE------------LARLQ 1718
Query: 636 REKAKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRD----KVQLMA 691
RE A + KR+E L AEL K + EM++LL A +E R Q +
Sbjct: 1719 REAAAATQ-KRQE------LEAELAKVRA---EMEVLLASKARAEEESRSTSEKSKQRLE 1768
Query: 692 AERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGAT---K 748
AE E+ E +R+R L E +R+ +++A+EDA R+ +AE + +G K
Sbjct: 1769 AEAGRFRELAEEAARLRALAEEAKRQ-RQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1827
Query: 749 QEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKD 808
E E L E + + + E ++L E+ + + ER+ Q+ K E +
Sbjct: 1828 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA--QLRKASDSELE 1885
Query: 809 E---LGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTL---RSQALELNKRK 862
L E L + QV+ ++L ++ EK A G E EL L RS A + + K
Sbjct: 1886 RQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELELGRIRSNAEDTLRSK 1940
Query: 863 AVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQ 922
+ A ++ E + R RE + + +S AA E+ + K A E++ RL+ K+E+
Sbjct: 1941 EQAELEAARQRQLAAEE-ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 1999
Query: 923 RKVEVYADADEILQEEIKEYKAR 945
R++ A+ + Q ++ + A+
Sbjct: 2000 RRLRERAEQESARQLQLAQEAAQ 2022
Score = 105 bits (261), Expect = 3e-22
Identities = 193/887 (21%), Positives = 363/887 (40%), Gaps = 150/887 (16%)
Query: 177 VELELQGRMEFSKAAV---SRVVEASDRLQRRVEELCQRVY--------SRGDSEPLSEA 225
++ ELQ + S+A + +R EA++R + R+EE + V RG +E +A
Sbjct: 1396 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1455
Query: 226 AQAHTRELGRENRRLQD----LATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTV-- 279
+A E + R+ Q+ L Q+Q++ R EL +V + E + +
Sbjct: 1456 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1515
Query: 280 -EDLQWDIE----KLRKREQKLNKHLAEALE--QLNSGYYVSGSSSGF--QGGQITLSMQ 330
E+L+ E +LR+ E + + + ALE Q ++ + + F + Q+ S+Q
Sbjct: 1516 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1575
Query: 331 KFEMLNAELEENQELANSRMAELEKLQAELQGAV-----RTNERLKVALRSLPEEVVRET 385
+ + A+L E E + AE E+ + E + + + NE L++ L++ EEV ++
Sbjct: 1576 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA--EEVAQQK 1633
Query: 386 GEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHLRHIEHMESDELGLQK------ 439
+ QA+ E+ + + +A + + + +E G +
Sbjct: 1634 S---LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1690
Query: 440 ----KLRTEVIQ-------LEDTLAQVRKEYEML---RIEFEQNLAANEQAGPINREMRH 485
+LR E Q LE+ LA++++E R E E LA + EM
Sbjct: 1691 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK------VRAEMEV 1744
Query: 486 LISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPAP 545
L++S + + +++ K++L +AE G+ R A +A L +
Sbjct: 1745 LLASKARAEEESRSTSEKSKQRL---EAEAGRFRELAEEAAR----LRALAEEAKRQRQL 1797
Query: 546 GKEEGGPGPVSTPDNRKEMAPVPGTTT---TTTSVKKEELVPSEEDFQGITPGAQGPSSR 602
+E+ E G T T + +E E + + R
Sbjct: 1798 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1857
Query: 603 GREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEET---KRKESELLKGLRAEL 659
E A+ K ++ ER L AS S +R+K VE+T +R+ E + L+A
Sbjct: 1858 LEEQAAQHKADIEER----LAQLRKASD-SELERQKGLVEDTLRQRRQVEEEILALKASF 1912
Query: 660 KKAQESQKEMKLLLDMYKSAPKE---QRDKVQLMAAERKAKAEVDELRSRIRELEERDRR 716
+KA + E++L L +S ++ +++ +L AA ++ A +E R R E +R
Sbjct: 1913 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR----EAEERV 1968
Query: 717 ESKKIADEDALRRIRQAEEQIEHLQRKLGATKQ--------------------------E 750
+ A+E+A R+ + A E++E L+ K+ ++ E
Sbjct: 1969 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2028
Query: 751 EEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSE----RIKANQIHKLLREE 806
E+A + Q + +Q +L QLR + +A + E R++A + R +
Sbjct: 2029 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2088
Query: 807 KDEL------GEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNK 860
+E E+ ++Q A ++K E+E A + E+ + QA +
Sbjct: 2089 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ---AEQAALRQKQAADAEM 2145
Query: 861 RKAVEAAQLAEDLKVQLEHVQTRLR---------------EIQPCLAES------RAARE 899
K + A+ K Q+E T LR E+Q AE+ R+ E
Sbjct: 2146 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2205
Query: 900 KESFNLKRAQEDISRLRRKLEKQRKVEVYADAD---EILQEEIKEYK 943
+E F+++ E++S+L+ ++E + + + D D LQEE ++ K
Sbjct: 2206 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2252
Score = 78.6 bits (192), Expect = 3e-14
Identities = 163/822 (19%), Positives = 326/822 (39%), Gaps = 105/822 (12%)
Query: 152 MQLRPPLSEPALAFVVALGASSSEEVELELQ-GRM--------------EFSKAAVSRVV 196
++ R + E LA + +++ + ELEL+ GR+ E A ++
Sbjct: 1895 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1954
Query: 197 EASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGR------ENRRLQDLATQLQEK 250
+R +R EE Q+ S E + +A E+ R E RRL++ A Q +
Sbjct: 1955 AEEERRRREAEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2012
Query: 251 HHRISLE------YSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEAL 304
+++ E +E + + + K E++ T++ Q +++LR + + EA
Sbjct: 2013 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2072
Query: 305 EQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAEL-QGA 363
E + + + Q +++ E L EE + A EKL+ E Q A
Sbjct: 2073 E--------ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2124
Query: 364 VRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSH 423
R + + ALR ++ + M + ++L+ K Q+++ L T
Sbjct: 2125 ARRAQAEQAALRQ------KQAADAEM--EKHKKFAEQTLRQKAQVEQE----LTTLRLQ 2172
Query: 424 LRHIEHMES---DELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPIN 480
L +H ++ +EL ++L+ E + +QV +E +R++ E+ ++ I
Sbjct: 2173 LEETDHQKNLLDEEL---QRLKAEATEAARQRSQVEEELFSVRVQMEE---LSKLKARIE 2226
Query: 481 REMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGV 540
E R LI + K + QR+ ++ E ++ + A+ S +A L + +
Sbjct: 2227 AENRALIL-------RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2279
Query: 541 SAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPG-AQGP 599
+ E+ + + + +E+ +ED + + A+
Sbjct: 2280 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2339
Query: 600 SSRGREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAEL 659
R EA +R+L + A+R K +V E R ++ + +
Sbjct: 2340 QGFQRTLEAERQRQLEMS--------------AEAERLKLRVAEMSRAQARAEEDAQRFR 2385
Query: 660 KKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERK-AKAEVDELRSRIRELEERDRRES 718
K+A+E ++ L + A +E+ VQ + +R+ + + + LR I ELE RE
Sbjct: 2386 KQAEEIGEK----LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE----REK 2437
Query: 719 KKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQ 778
+K+ E L +++ E Q ++ L T+ +++ LSE D Q ++++ +L Q
Sbjct: 2438 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2497
Query: 779 LREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERAL 838
++ E KA Q+ + + ++ ++ ++ L + ++ + EE R
Sbjct: 2498 FQD----------EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2547
Query: 839 QGSLGGVEKELTLRSQALELNKRKAVEAAQLAED----LKVQLEHVQTRLREIQPCLAES 894
Q L +E++ + + L ++ E QL E+ E V L
Sbjct: 2548 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2607
Query: 895 RAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQ 936
R A + + + + LRRK+ QR E + E LQ
Sbjct: 2608 RDALDGPAAEAE-PEHSFDGLRRKVSAQRLQEAGILSAEELQ 2648
Score = 76.3 bits (186), Expect = 1e-13
Identities = 154/802 (19%), Positives = 309/802 (38%), Gaps = 97/802 (12%)
Query: 19 EKKLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNKKLAERLEQRQACEDELRERIE 78
+K L+ EE+ R + E + KV + + +L ER EQ A + +L + E
Sbjct: 1969 QKSLAAEEEAARQ-----RKAALEEVERLKAKVEEAR--RLRERAEQESARQLQLAQ--E 2019
Query: 79 KLEKR-QATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDGTP 137
+KR QA + A V + +L +T+ Q E S + G E
Sbjct: 2020 AAQKRLQAEEKAHAFAVQQKEQELQQTL---------QQEQSVLDQLRGEAEAARRAAEE 2070
Query: 138 LPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELELQGRMEFSKAAVSRVVE 197
E R+ Q R + E L S+ E+ + Q + K E
Sbjct: 2071 AEEARVQAEREAA--QSRRQVEEAE-----RLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2123
Query: 198 ASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRISLE 257
A+ R Q L Q+ + + E + A+ R+ + + L L QL+E H+ +L
Sbjct: 2124 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2183
Query: 258 YSELQDKVTSAETKVLEMETTVEDLQW-------DIEKLRKREQKLNKHLAEALEQLNSG 310
ELQ ++ + T+ + VE+ + ++ KL+ R + N+ L ++ N+
Sbjct: 2184 DEELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI-LRDKDNTQ 2241
Query: 311 YYVSGSSSGF-----QGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVR 365
++ + + +++++ Q+ L EE +LA R A EK+ E AV+
Sbjct: 2242 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE--DLAQQR-ALAEKMLKEKMQAVQ 2298
Query: 366 TNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQL-DEARGLLLATKNSHL 424
RLK L + + + Q Q L + Q+ QL +E +G +
Sbjct: 2299 EATRLKAEAELLQQ-------QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2351
Query: 425 RHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMR 484
R +E E +L+ V ++ A+ ++ + R + E+ + +E
Sbjct: 2352 RQLEMSAEAE-----RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2406
Query: 485 HLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPA 544
L+ +L+ Q DA+R + + E++ E KL+ +A + + + +
Sbjct: 2407 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET 2466
Query: 545 PGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGR 604
++ + R+ ++E E+ FQ AQ + R
Sbjct: 2467 QALQQSFLSEKDSLLQRERFI-------------EQEKAKLEQLFQDEVAKAQ----QLR 2509
Query: 605 EPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAELKKAQE 664
E + R ++++ + R A +EE +R++ E +G+R + ++ Q+
Sbjct: 2510 EEQQRQQQQMEQER----------------QRLVASMEEARRRQHEAEEGVRRKQEELQQ 2553
Query: 665 SQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADE 724
+++ + ++ + R+++QL+ + +A E + + + + D
Sbjct: 2554 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDG 2613
Query: 725 DALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDD 784
A + E + L+RK+ A + +E +LS ++ A Q + +L ++D
Sbjct: 2614 PAAE--AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA------QGHTTVDELARRED 2665
Query: 785 ANFKLMSERIKANQIHKLLREE 806
L A + K E+
Sbjct: 2666 VRHYLQGRSSIAGLLLKATNEK 2687
Score = 74.7 bits (182), Expect = 4e-13
Identities = 209/1050 (19%), Positives = 386/1050 (36%), Gaps = 179/1050 (17%)
Query: 19 EKKLSREEKTTTTLIEPIRLGGISSTEEM-DLKVLQFKNKKLAERLEQRQACEDELRERI 77
E + +RE++ +E +RL + + +V + + ++A QR A E EL+ +
Sbjct: 1502 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA-EAELQSKR 1560
Query: 78 EKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDGTP 137
++ A + +L + AQL E E R + Q E A E +
Sbjct: 1561 ASFAEKTAQLERSLQEEHVAVAQLREEAE---RRAQQQAEAERAREEAEREL-------- 1609
Query: 138 LPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELELQGRMEFSKAAVSRVVE 197
E + + L ++L+ + A EE E E + R + + AV +
Sbjct: 1610 --ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1667
Query: 198 ASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRISLE 257
A L++ QR + G ++ A Q E RL+ Q +++ + E
Sbjct: 1668 AEQELEK------QRQLAEGTAQQRLAAEQ--------ELIRLRAETEQGEQQRQLLEEE 1713
Query: 258 YSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSS 317
+ LQ + +A K E+E ++ K+R + L A A E+ S S
Sbjct: 1714 LARLQREAAAATQKRQELEA-------ELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1766
Query: 318 SGFQGGQITLSMQKFEMLNAELEEN-------QELANSRMAELEKLQAELQGAVRTNERL 370
+ G+ ++ L A EE +E A + AE E++ AE A+ RL
Sbjct: 1767 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1826
Query: 371 KVALRSLPEEVVRETGEYRMLQA----QFSLLYNESLQVKTQLDEARGLLLATKNSHLRH 426
K +E E R L Q L ++ Q K ++E L +S L
Sbjct: 1827 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1886
Query: 427 IEHMESDELGLQKKLRTEVIQL-------------------------EDTLA-------- 453
+ + D L ++++ E++ L EDTL
Sbjct: 1887 QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELE 1946
Query: 454 -----QVRKEYEMLRIEFEQ----NLAANEQAGPINREMRHLISSLQ---NHNHQLKGDA 501
Q+ E E R E E+ +LAA E+A + + L+ +L+ A
Sbjct: 1947 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2006
Query: 502 QRYKRKLREVQAEIGKLRAQASGSAHSTP--------NLGHPEDSGVSAPAPGKEEGGPG 553
++ + ++ E + R QA AH+ ++ V G+ E
Sbjct: 2007 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2066
Query: 554 PVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRE 613
+ + A + + E L S E+ AQ + + R+ +
Sbjct: 2067 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2126
Query: 614 LREREGPSLGPPPVASA--------LSRADREKAKVEET--------------KRKESEL 651
+ E +L A A + R+KA+VE+ K E
Sbjct: 2127 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2186
Query: 652 LKGLRAELKKA--QESQKEMKLLL---------------------------DMYKSAPKE 682
L+ L+AE +A Q SQ E +L D + +E
Sbjct: 2187 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2246
Query: 683 QRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQR 742
+ +K++ +A E + + +R+R+L E D + + +A E L+ QA ++ L
Sbjct: 2247 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA-EKMLKEKMQAVQEATRL-- 2303
Query: 743 KLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKL 802
K E E L + ++ + +QE ++ QQL E+ + +
Sbjct: 2304 -----KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE--------- 2349
Query: 803 LREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRK 862
R+ + E+ + LK +V + EE + + +E+ + EL ++
Sbjct: 2350 -RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ----AEEIGEKLHRTELATQE 2404
Query: 863 AVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRK--LE 920
V Q E + Q +H RLRE L + ++E+ L+ E++ ++++ L+
Sbjct: 2405 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQ 2464
Query: 921 KQRKVE--VYADADEILQEE--IKEYKARL 946
+ + ++ ++ D +LQ E I++ KA+L
Sbjct: 2465 ETQALQQSFLSEKDSLLQRERFIEQEKAKL 2494
Score = 55.8 bits (133), Expect = 2e-07
Identities = 129/664 (19%), Positives = 256/664 (38%), Gaps = 70/664 (10%)
Query: 16 GPPEKKLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNKKLAERLEQRQACEDELRE 75
G E E+ ++ R S + + + L+ ++ A+ Q QA ++LR+
Sbjct: 2059 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2118
Query: 76 RIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDG 135
E+ R+A + L + + +A + H+ E + +A QE T
Sbjct: 2119 EAEQEAARRAQAEQAAL-------RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2171
Query: 136 TPLPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELE----LQGRMEFSKAA 191
L D L +L+ +E A S V++E L+ R+E A
Sbjct: 2172 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2231
Query: 192 VSRVVEASDRLQRRVEELCQRVYSRGDSEP-LSEAAQ--AHTRELGRENRRLQDLATQLQ 248
+ ++ D QR ++E +++ + LS AAQ A R+L E DLA Q
Sbjct: 2232 L--ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE-----DLAQQRA 2284
Query: 249 EKHHRISLEYSELQDKVT-SAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQL 307
+ + +Q+ AE ++L+ + E Q +L++ ++++ + LAE +
Sbjct: 2285 LAEKMLKEKMQAVQEATRLKAEAELLQQQK--ELAQEQARRLQEDKEQMAQQLAEETQGF 2342
Query: 308 NSGYYVSGSSS---GFQGGQITLSMQKFEMLNAELEEN------------QELANSRMAE 352
+ ++ L + + A EE+ ++L + +A
Sbjct: 2343 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2402
Query: 353 LEK------LQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVK 406
EK L+ + Q + ERL+ A+ L E + E ++LQ + + +++Q +
Sbjct: 2403 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM--QTVQQE 2460
Query: 407 TQLDEARGL---LLATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLR 463
L E + L L+ K+S L+ +E ++ L++ + EV + + + +++ + +
Sbjct: 2461 QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2520
Query: 464 IEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQAS 523
E ++ +A+ E+A E + Q QL+ ++ + L E + + + Q
Sbjct: 2521 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL-REQLQLL 2579
Query: 524 GSAHSTPNLGHPEDSGVSAPA-----PGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVK 578
H L H E+ S A P + GP + + G ++ +
Sbjct: 2580 EEQHRAA-LAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQR 2635
Query: 579 KEEL-VPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVASALSRADRE 637
+E + S E+ Q + G R + R + G +A L +A E
Sbjct: 2636 LQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQ---------GRSSIAGLLLKATNE 2686
Query: 638 KAKV 641
K V
Sbjct: 2687 KLSV 2690
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 105 bits (261), Expect = 3e-22
Identities = 207/923 (22%), Positives = 357/923 (38%), Gaps = 152/923 (16%)
Query: 56 NKKLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQ 115
++ + E+L Q QA +E+ EK+E+ Q + + Y QL T +A L
Sbjct: 1227 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL-VTYKAQLE----- 1280
Query: 116 GELSSAPEAPGTQEGPTCDGTPLPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSE 175
++S + P Q G SE + V L SE
Sbjct: 1281 -PVASPAKKPKVQSG----------------------------SESVIQEYVDLRTHYSE 1311
Query: 176 EVELELQGRMEFSKAAVSRVVEASDRL--QRRVEELCQRVYSRGDSEPLSEAAQAHTREL 233
L Q ++F + R+ E +RL Q+R EE + E + A+AH +
Sbjct: 1312 LTTLTSQ-YIKFISETLRRM-EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1369
Query: 234 GRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEM----ETTVEDLQWDIEKL 289
+ R ++L ++QE+ R + Q + S + ++ ++ E ++ E
Sbjct: 1370 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1429
Query: 290 RKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSR 349
+ ++ + + QL + G + G + + L A EE +
Sbjct: 1430 ERSRLRIEEEIRVVRLQLEATERQRGGAEG-----------ELQALRARAEEAEAQKRQA 1478
Query: 350 MAELEKLQAELQGAVRTNERLKVALRSLPE---EVVRETGEYRMLQAQFSLLYNESLQVK 406
E E+L+ ++Q + + +V L S + E RE + R LQA L +
Sbjct: 1479 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE--KQRALQALEEL--------R 1528
Query: 407 TQLDEARGLLLATKNSHLRHIE-----HMESDELGLQKKLRT---EVIQLEDTLAQVRKE 458
Q +EA L + R ++ S E LQ K + + QLE +L +
Sbjct: 1529 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1588
Query: 459 YEMLRIEFEQNLAANEQAGPINREMRHLISSLQ---NHNHQLKGDAQRYKRKLREVQAEI 515
LR E E+ +A E + Q N +L+ A+ ++ QAE
Sbjct: 1589 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1648
Query: 516 GKLRAQASGSAHSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTT 575
K + +A A G E+ V ++E K+ GT
Sbjct: 1649 EKQKEEAEREARRR---GKAEEQAVRQRELAEQE----------LEKQRQLAEGTAQQRL 1695
Query: 576 SVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVASALSRAD 635
+ ++E + E QG +R+L E E L+R
Sbjct: 1696 AAEQELIRLRAETEQG-----------------EQQRQLLEEE------------LARLQ 1726
Query: 636 REKAKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRD----KVQLMA 691
RE A + KR+E L AEL K + EM++LL A +E R Q +
Sbjct: 1727 REAAAATQ-KRQE------LEAELAKVRA---EMEVLLASKARAEEESRSTSEKSKQRLE 1776
Query: 692 AERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGAT---K 748
AE E+ E +R+R L E +R+ +++A+EDA R+ +AE + +G K
Sbjct: 1777 AEAGRFRELAEEAARLRALAEEAKRQ-RQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1835
Query: 749 QEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKD 808
E E L E + + + E ++L E+ + + ER+ Q+ K E +
Sbjct: 1836 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA--QLRKASDSELE 1893
Query: 809 E---LGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTL---RSQALELNKRK 862
L E L + QV+ ++L ++ EK A G E EL L RS A + + K
Sbjct: 1894 RQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELELGRIRSNAEDTLRSK 1948
Query: 863 AVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQ 922
+ A ++ E + R RE + + +S AA E+ + K A E++ RL+ K+E+
Sbjct: 1949 EQAELEAARQRQLAAEE-ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2007
Query: 923 RKVEVYADADEILQEEIKEYKAR 945
R++ A+ + Q ++ + A+
Sbjct: 2008 RRLRERAEQESARQLQLAQEAAQ 2030
Score = 105 bits (261), Expect = 3e-22
Identities = 193/887 (21%), Positives = 363/887 (40%), Gaps = 150/887 (16%)
Query: 177 VELELQGRMEFSKAAV---SRVVEASDRLQRRVEELCQRVY--------SRGDSEPLSEA 225
++ ELQ + S+A + +R EA++R + R+EE + V RG +E +A
Sbjct: 1404 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1463
Query: 226 AQAHTRELGRENRRLQD----LATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTV-- 279
+A E + R+ Q+ L Q+Q++ R EL +V + E + +
Sbjct: 1464 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1523
Query: 280 -EDLQWDIE----KLRKREQKLNKHLAEALE--QLNSGYYVSGSSSGF--QGGQITLSMQ 330
E+L+ E +LR+ E + + + ALE Q ++ + + F + Q+ S+Q
Sbjct: 1524 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1583
Query: 331 KFEMLNAELEENQELANSRMAELEKLQAELQGAV-----RTNERLKVALRSLPEEVVRET 385
+ + A+L E E + AE E+ + E + + + NE L++ L++ EEV ++
Sbjct: 1584 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA--EEVAQQK 1641
Query: 386 GEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHLRHIEHMESDELGLQK------ 439
+ QA+ E+ + + +A + + + +E G +
Sbjct: 1642 S---LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1698
Query: 440 ----KLRTEVIQ-------LEDTLAQVRKEYEML---RIEFEQNLAANEQAGPINREMRH 485
+LR E Q LE+ LA++++E R E E LA + EM
Sbjct: 1699 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK------VRAEMEV 1752
Query: 486 LISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPAP 545
L++S + + +++ K++L +AE G+ R A +A L +
Sbjct: 1753 LLASKARAEEESRSTSEKSKQRL---EAEAGRFRELAEEAAR----LRALAEEAKRQRQL 1805
Query: 546 GKEEGGPGPVSTPDNRKEMAPVPGTTT---TTTSVKKEELVPSEEDFQGITPGAQGPSSR 602
+E+ E G T T + +E E + + R
Sbjct: 1806 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1865
Query: 603 GREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEET---KRKESELLKGLRAEL 659
E A+ K ++ ER L AS S +R+K VE+T +R+ E + L+A
Sbjct: 1866 LEEQAAQHKADIEER----LAQLRKASD-SELERQKGLVEDTLRQRRQVEEEILALKASF 1920
Query: 660 KKAQESQKEMKLLLDMYKSAPKE---QRDKVQLMAAERKAKAEVDELRSRIRELEERDRR 716
+KA + E++L L +S ++ +++ +L AA ++ A +E R R E +R
Sbjct: 1921 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR----EAEERV 1976
Query: 717 ESKKIADEDALRRIRQAEEQIEHLQRKLGATKQ--------------------------E 750
+ A+E+A R+ + A E++E L+ K+ ++ E
Sbjct: 1977 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2036
Query: 751 EEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSE----RIKANQIHKLLREE 806
E+A + Q + +Q +L QLR + +A + E R++A + R +
Sbjct: 2037 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2096
Query: 807 KDEL------GEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNK 860
+E E+ ++Q A ++K E+E A + E+ + QA +
Sbjct: 2097 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ---AEQAALRQKQAADAEM 2153
Query: 861 RKAVEAAQLAEDLKVQLEHVQTRLR---------------EIQPCLAES------RAARE 899
K + A+ K Q+E T LR E+Q AE+ R+ E
Sbjct: 2154 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2213
Query: 900 KESFNLKRAQEDISRLRRKLEKQRKVEVYADAD---EILQEEIKEYK 943
+E F+++ E++S+L+ ++E + + + D D LQEE ++ K
Sbjct: 2214 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2260
Score = 78.6 bits (192), Expect = 3e-14
Identities = 163/822 (19%), Positives = 326/822 (39%), Gaps = 105/822 (12%)
Query: 152 MQLRPPLSEPALAFVVALGASSSEEVELELQ-GRM--------------EFSKAAVSRVV 196
++ R + E LA + +++ + ELEL+ GR+ E A ++
Sbjct: 1903 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1962
Query: 197 EASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGR------ENRRLQDLATQLQEK 250
+R +R EE Q+ S E + +A E+ R E RRL++ A Q +
Sbjct: 1963 AEEERRRREAEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2020
Query: 251 HHRISLE------YSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEAL 304
+++ E +E + + + K E++ T++ Q +++LR + + EA
Sbjct: 2021 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2080
Query: 305 EQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAEL-QGA 363
E + + + Q +++ E L EE + A EKL+ E Q A
Sbjct: 2081 E--------ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2132
Query: 364 VRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSH 423
R + + ALR ++ + M + ++L+ K Q+++ L T
Sbjct: 2133 ARRAQAEQAALRQ------KQAADAEM--EKHKKFAEQTLRQKAQVEQE----LTTLRLQ 2180
Query: 424 LRHIEHMES---DELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPIN 480
L +H ++ +EL ++L+ E + +QV +E +R++ E+ ++ I
Sbjct: 2181 LEETDHQKNLLDEEL---QRLKAEATEAARQRSQVEEELFSVRVQMEE---LSKLKARIE 2234
Query: 481 REMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGV 540
E R LI + K + QR+ ++ E ++ + A+ S +A L + +
Sbjct: 2235 AENRALIL-------RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2287
Query: 541 SAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPG-AQGP 599
+ E+ + + + +E+ +ED + + A+
Sbjct: 2288 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2347
Query: 600 SSRGREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAEL 659
R EA +R+L + A+R K +V E R ++ + +
Sbjct: 2348 QGFQRTLEAERQRQLEMS--------------AEAERLKLRVAEMSRAQARAEEDAQRFR 2393
Query: 660 KKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERK-AKAEVDELRSRIRELEERDRRES 718
K+A+E ++ L + A +E+ VQ + +R+ + + + LR I ELE RE
Sbjct: 2394 KQAEEIGEK----LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE----REK 2445
Query: 719 KKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQ 778
+K+ E L +++ E Q ++ L T+ +++ LSE D Q ++++ +L Q
Sbjct: 2446 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2505
Query: 779 LREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERAL 838
++ E KA Q+ + + ++ ++ ++ L + ++ + EE R
Sbjct: 2506 FQD----------EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2555
Query: 839 QGSLGGVEKELTLRSQALELNKRKAVEAAQLAED----LKVQLEHVQTRLREIQPCLAES 894
Q L +E++ + + L ++ E QL E+ E V L
Sbjct: 2556 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2615
Query: 895 RAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQ 936
R A + + + + LRRK+ QR E + E LQ
Sbjct: 2616 RDALDGPAAEAE-PEHSFDGLRRKVSAQRLQEAGILSAEELQ 2656
Score = 76.3 bits (186), Expect = 1e-13
Identities = 154/802 (19%), Positives = 309/802 (38%), Gaps = 97/802 (12%)
Query: 19 EKKLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNKKLAERLEQRQACEDELRERIE 78
+K L+ EE+ R + E + KV + + +L ER EQ A + +L + E
Sbjct: 1977 QKSLAAEEEAARQ-----RKAALEEVERLKAKVEEAR--RLRERAEQESARQLQLAQ--E 2027
Query: 79 KLEKR-QATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDGTP 137
+KR QA + A V + +L +T+ Q E S + G E
Sbjct: 2028 AAQKRLQAEEKAHAFAVQQKEQELQQTL---------QQEQSVLDQLRGEAEAARRAAEE 2078
Query: 138 LPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELELQGRMEFSKAAVSRVVE 197
E R+ Q R + E L S+ E+ + Q + K E
Sbjct: 2079 AEEARVQAEREAA--QSRRQVEEAE-----RLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2131
Query: 198 ASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRISLE 257
A+ R Q L Q+ + + E + A+ R+ + + L L QL+E H+ +L
Sbjct: 2132 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2191
Query: 258 YSELQDKVTSAETKVLEMETTVEDLQW-------DIEKLRKREQKLNKHLAEALEQLNSG 310
ELQ ++ + T+ + VE+ + ++ KL+ R + N+ L ++ N+
Sbjct: 2192 DEELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI-LRDKDNTQ 2249
Query: 311 YYVSGSSSGF-----QGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVR 365
++ + + +++++ Q+ L EE +LA R A EK+ E AV+
Sbjct: 2250 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE--DLAQQR-ALAEKMLKEKMQAVQ 2306
Query: 366 TNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQL-DEARGLLLATKNSHL 424
RLK L + + + Q Q L + Q+ QL +E +G +
Sbjct: 2307 EATRLKAEAELLQQ-------QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2359
Query: 425 RHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMR 484
R +E E +L+ V ++ A+ ++ + R + E+ + +E
Sbjct: 2360 RQLEMSAEAE-----RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2414
Query: 485 HLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPA 544
L+ +L+ Q DA+R + + E++ E KL+ +A + + + +
Sbjct: 2415 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET 2474
Query: 545 PGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGR 604
++ + R+ ++E E+ FQ AQ + R
Sbjct: 2475 QALQQSFLSEKDSLLQRERFI-------------EQEKAKLEQLFQDEVAKAQ----QLR 2517
Query: 605 EPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAELKKAQE 664
E + R ++++ + R A +EE +R++ E +G+R + ++ Q+
Sbjct: 2518 EEQQRQQQQMEQER----------------QRLVASMEEARRRQHEAEEGVRRKQEELQQ 2561
Query: 665 SQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADE 724
+++ + ++ + R+++QL+ + +A E + + + + D
Sbjct: 2562 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDG 2621
Query: 725 DALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDD 784
A + E + L+RK+ A + +E +LS ++ A Q + +L ++D
Sbjct: 2622 PAAE--AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA------QGHTTVDELARRED 2673
Query: 785 ANFKLMSERIKANQIHKLLREE 806
L A + K E+
Sbjct: 2674 VRHYLQGRSSIAGLLLKATNEK 2695
Score = 74.7 bits (182), Expect = 4e-13
Identities = 209/1050 (19%), Positives = 386/1050 (36%), Gaps = 179/1050 (17%)
Query: 19 EKKLSREEKTTTTLIEPIRLGGISSTEEM-DLKVLQFKNKKLAERLEQRQACEDELRERI 77
E + +RE++ +E +RL + + +V + + ++A QR A E EL+ +
Sbjct: 1510 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA-EAELQSKR 1568
Query: 78 EKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDGTP 137
++ A + +L + AQL E E R + Q E A E +
Sbjct: 1569 ASFAEKTAQLERSLQEEHVAVAQLREEAE---RRAQQQAEAERAREEAEREL-------- 1617
Query: 138 LPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELELQGRMEFSKAAVSRVVE 197
E + + L ++L+ + A EE E E + R + + AV +
Sbjct: 1618 --ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1675
Query: 198 ASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRISLE 257
A L++ QR + G ++ A Q E RL+ Q +++ + E
Sbjct: 1676 AEQELEK------QRQLAEGTAQQRLAAEQ--------ELIRLRAETEQGEQQRQLLEEE 1721
Query: 258 YSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSS 317
+ LQ + +A K E+E ++ K+R + L A A E+ S S
Sbjct: 1722 LARLQREAAAATQKRQELEA-------ELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1774
Query: 318 SGFQGGQITLSMQKFEMLNAELEEN-------QELANSRMAELEKLQAELQGAVRTNERL 370
+ G+ ++ L A EE +E A + AE E++ AE A+ RL
Sbjct: 1775 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1834
Query: 371 KVALRSLPEEVVRETGEYRMLQA----QFSLLYNESLQVKTQLDEARGLLLATKNSHLRH 426
K +E E R L Q L ++ Q K ++E L +S L
Sbjct: 1835 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1894
Query: 427 IEHMESDELGLQKKLRTEVIQL-------------------------EDTLA-------- 453
+ + D L ++++ E++ L EDTL
Sbjct: 1895 QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELE 1954
Query: 454 -----QVRKEYEMLRIEFEQ----NLAANEQAGPINREMRHLISSLQ---NHNHQLKGDA 501
Q+ E E R E E+ +LAA E+A + + L+ +L+ A
Sbjct: 1955 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2014
Query: 502 QRYKRKLREVQAEIGKLRAQASGSAHSTP--------NLGHPEDSGVSAPAPGKEEGGPG 553
++ + ++ E + R QA AH+ ++ V G+ E
Sbjct: 2015 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2074
Query: 554 PVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRE 613
+ + A + + E L S E+ AQ + + R+ +
Sbjct: 2075 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2134
Query: 614 LREREGPSLGPPPVASA--------LSRADREKAKVEET--------------KRKESEL 651
+ E +L A A + R+KA+VE+ K E
Sbjct: 2135 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2194
Query: 652 LKGLRAELKKA--QESQKEMKLLL---------------------------DMYKSAPKE 682
L+ L+AE +A Q SQ E +L D + +E
Sbjct: 2195 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2254
Query: 683 QRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQR 742
+ +K++ +A E + + +R+R+L E D + + +A E L+ QA ++ L
Sbjct: 2255 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA-EKMLKEKMQAVQEATRL-- 2311
Query: 743 KLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKL 802
K E E L + ++ + +QE ++ QQL E+ + +
Sbjct: 2312 -----KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE--------- 2357
Query: 803 LREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRK 862
R+ + E+ + LK +V + EE + + +E+ + EL ++
Sbjct: 2358 -RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ----AEEIGEKLHRTELATQE 2412
Query: 863 AVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRK--LE 920
V Q E + Q +H RLRE L + ++E+ L+ E++ ++++ L+
Sbjct: 2413 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQ 2472
Query: 921 KQRKVE--VYADADEILQEE--IKEYKARL 946
+ + ++ ++ D +LQ E I++ KA+L
Sbjct: 2473 ETQALQQSFLSEKDSLLQRERFIEQEKAKL 2502
Score = 55.8 bits (133), Expect = 2e-07
Identities = 129/664 (19%), Positives = 256/664 (38%), Gaps = 70/664 (10%)
Query: 16 GPPEKKLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNKKLAERLEQRQACEDELRE 75
G E E+ ++ R S + + + L+ ++ A+ Q QA ++LR+
Sbjct: 2067 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2126
Query: 76 RIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDG 135
E+ R+A + L + + +A + H+ E + +A QE T
Sbjct: 2127 EAEQEAARRAQAEQAAL-------RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2179
Query: 136 TPLPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELE----LQGRMEFSKAA 191
L D L +L+ +E A S V++E L+ R+E A
Sbjct: 2180 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2239
Query: 192 VSRVVEASDRLQRRVEELCQRVYSRGDSEP-LSEAAQ--AHTRELGRENRRLQDLATQLQ 248
+ ++ D QR ++E +++ + LS AAQ A R+L E DLA Q
Sbjct: 2240 L--ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE-----DLAQQRA 2292
Query: 249 EKHHRISLEYSELQDKVT-SAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQL 307
+ + +Q+ AE ++L+ + E Q +L++ ++++ + LAE +
Sbjct: 2293 LAEKMLKEKMQAVQEATRLKAEAELLQQQK--ELAQEQARRLQEDKEQMAQQLAEETQGF 2350
Query: 308 NSGYYVSGSSS---GFQGGQITLSMQKFEMLNAELEEN------------QELANSRMAE 352
+ ++ L + + A EE+ ++L + +A
Sbjct: 2351 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2410
Query: 353 LEK------LQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVK 406
EK L+ + Q + ERL+ A+ L E + E ++LQ + + +++Q +
Sbjct: 2411 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM--QTVQQE 2468
Query: 407 TQLDEARGL---LLATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLR 463
L E + L L+ K+S L+ +E ++ L++ + EV + + + +++ + +
Sbjct: 2469 QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2528
Query: 464 IEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQAS 523
E ++ +A+ E+A E + Q QL+ ++ + L E + + + Q
Sbjct: 2529 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL-REQLQLL 2587
Query: 524 GSAHSTPNLGHPEDSGVSAPA-----PGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVK 578
H L H E+ S A P + GP + + G ++ +
Sbjct: 2588 EEQHRAA-LAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQR 2643
Query: 579 KEEL-VPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVASALSRADRE 637
+E + S E+ Q + G R + R + G +A L +A E
Sbjct: 2644 LQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQ---------GRSSIAGLLLKATNE 2694
Query: 638 KAKV 641
K V
Sbjct: 2695 KLSV 2698
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 105 bits (261), Expect = 3e-22
Identities = 207/923 (22%), Positives = 357/923 (38%), Gaps = 152/923 (16%)
Query: 56 NKKLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQ 115
++ + E+L Q QA +E+ EK+E+ Q + + Y QL T +A L
Sbjct: 1268 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL-VTYKAQLE----- 1321
Query: 116 GELSSAPEAPGTQEGPTCDGTPLPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSE 175
++S + P Q G SE + V L SE
Sbjct: 1322 -PVASPAKKPKVQSG----------------------------SESVIQEYVDLRTHYSE 1352
Query: 176 EVELELQGRMEFSKAAVSRVVEASDRL--QRRVEELCQRVYSRGDSEPLSEAAQAHTREL 233
L Q ++F + R+ E +RL Q+R EE + E + A+AH +
Sbjct: 1353 LTTLTSQ-YIKFISETLRRM-EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1410
Query: 234 GRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEM----ETTVEDLQWDIEKL 289
+ R ++L ++QE+ R + Q + S + ++ ++ E ++ E
Sbjct: 1411 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1470
Query: 290 RKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSR 349
+ ++ + + QL + G + G + + L A EE +
Sbjct: 1471 ERSRLRIEEEIRVVRLQLEATERQRGGAEG-----------ELQALRARAEEAEAQKRQA 1519
Query: 350 MAELEKLQAELQGAVRTNERLKVALRSLPE---EVVRETGEYRMLQAQFSLLYNESLQVK 406
E E+L+ ++Q + + +V L S + E RE + R LQA L +
Sbjct: 1520 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE--KQRALQALEEL--------R 1569
Query: 407 TQLDEARGLLLATKNSHLRHIE-----HMESDELGLQKKLRT---EVIQLEDTLAQVRKE 458
Q +EA L + R ++ S E LQ K + + QLE +L +
Sbjct: 1570 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1629
Query: 459 YEMLRIEFEQNLAANEQAGPINREMRHLISSLQ---NHNHQLKGDAQRYKRKLREVQAEI 515
LR E E+ +A E + Q N +L+ A+ ++ QAE
Sbjct: 1630 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1689
Query: 516 GKLRAQASGSAHSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTT 575
K + +A A G E+ V ++E K+ GT
Sbjct: 1690 EKQKEEAEREARRR---GKAEEQAVRQRELAEQE----------LEKQRQLAEGTAQQRL 1736
Query: 576 SVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVASALSRAD 635
+ ++E + E QG +R+L E E L+R
Sbjct: 1737 AAEQELIRLRAETEQG-----------------EQQRQLLEEE------------LARLQ 1767
Query: 636 REKAKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRD----KVQLMA 691
RE A + KR+E L AEL K + EM++LL A +E R Q +
Sbjct: 1768 REAAAATQ-KRQE------LEAELAKVRA---EMEVLLASKARAEEESRSTSEKSKQRLE 1817
Query: 692 AERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGAT---K 748
AE E+ E +R+R L E +R+ +++A+EDA R+ +AE + +G K
Sbjct: 1818 AEAGRFRELAEEAARLRALAEEAKRQ-RQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1876
Query: 749 QEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKD 808
E E L E + + + E ++L E+ + + ER+ Q+ K E +
Sbjct: 1877 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA--QLRKASDSELE 1934
Query: 809 E---LGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTL---RSQALELNKRK 862
L E L + QV+ ++L ++ EK A G E EL L RS A + + K
Sbjct: 1935 RQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELELGRIRSNAEDTLRSK 1989
Query: 863 AVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQ 922
+ A ++ E + R RE + + +S AA E+ + K A E++ RL+ K+E+
Sbjct: 1990 EQAELEAARQRQLAAEE-ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2048
Query: 923 RKVEVYADADEILQEEIKEYKAR 945
R++ A+ + Q ++ + A+
Sbjct: 2049 RRLRERAEQESARQLQLAQEAAQ 2071
Score = 105 bits (261), Expect = 3e-22
Identities = 193/887 (21%), Positives = 363/887 (40%), Gaps = 150/887 (16%)
Query: 177 VELELQGRMEFSKAAV---SRVVEASDRLQRRVEELCQRVY--------SRGDSEPLSEA 225
++ ELQ + S+A + +R EA++R + R+EE + V RG +E +A
Sbjct: 1445 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1504
Query: 226 AQAHTRELGRENRRLQD----LATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTV-- 279
+A E + R+ Q+ L Q+Q++ R EL +V + E + +
Sbjct: 1505 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1564
Query: 280 -EDLQWDIE----KLRKREQKLNKHLAEALE--QLNSGYYVSGSSSGF--QGGQITLSMQ 330
E+L+ E +LR+ E + + + ALE Q ++ + + F + Q+ S+Q
Sbjct: 1565 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1624
Query: 331 KFEMLNAELEENQELANSRMAELEKLQAELQGAV-----RTNERLKVALRSLPEEVVRET 385
+ + A+L E E + AE E+ + E + + + NE L++ L++ EEV ++
Sbjct: 1625 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA--EEVAQQK 1682
Query: 386 GEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHLRHIEHMESDELGLQK------ 439
+ QA+ E+ + + +A + + + +E G +
Sbjct: 1683 S---LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1739
Query: 440 ----KLRTEVIQ-------LEDTLAQVRKEYEML---RIEFEQNLAANEQAGPINREMRH 485
+LR E Q LE+ LA++++E R E E LA + EM
Sbjct: 1740 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK------VRAEMEV 1793
Query: 486 LISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPAP 545
L++S + + +++ K++L +AE G+ R A +A L +
Sbjct: 1794 LLASKARAEEESRSTSEKSKQRL---EAEAGRFRELAEEAAR----LRALAEEAKRQRQL 1846
Query: 546 GKEEGGPGPVSTPDNRKEMAPVPGTTT---TTTSVKKEELVPSEEDFQGITPGAQGPSSR 602
+E+ E G T T + +E E + + R
Sbjct: 1847 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1906
Query: 603 GREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEET---KRKESELLKGLRAEL 659
E A+ K ++ ER L AS S +R+K VE+T +R+ E + L+A
Sbjct: 1907 LEEQAAQHKADIEER----LAQLRKASD-SELERQKGLVEDTLRQRRQVEEEILALKASF 1961
Query: 660 KKAQESQKEMKLLLDMYKSAPKE---QRDKVQLMAAERKAKAEVDELRSRIRELEERDRR 716
+KA + E++L L +S ++ +++ +L AA ++ A +E R R E +R
Sbjct: 1962 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR----EAEERV 2017
Query: 717 ESKKIADEDALRRIRQAEEQIEHLQRKLGATKQ--------------------------E 750
+ A+E+A R+ + A E++E L+ K+ ++ E
Sbjct: 2018 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2077
Query: 751 EEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSE----RIKANQIHKLLREE 806
E+A + Q + +Q +L QLR + +A + E R++A + R +
Sbjct: 2078 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2137
Query: 807 KDEL------GEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNK 860
+E E+ ++Q A ++K E+E A + E+ + QA +
Sbjct: 2138 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ---AEQAALRQKQAADAEM 2194
Query: 861 RKAVEAAQLAEDLKVQLEHVQTRLR---------------EIQPCLAES------RAARE 899
K + A+ K Q+E T LR E+Q AE+ R+ E
Sbjct: 2195 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2254
Query: 900 KESFNLKRAQEDISRLRRKLEKQRKVEVYADAD---EILQEEIKEYK 943
+E F+++ E++S+L+ ++E + + + D D LQEE ++ K
Sbjct: 2255 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2301
Score = 78.6 bits (192), Expect = 3e-14
Identities = 163/822 (19%), Positives = 326/822 (39%), Gaps = 105/822 (12%)
Query: 152 MQLRPPLSEPALAFVVALGASSSEEVELELQ-GRM--------------EFSKAAVSRVV 196
++ R + E LA + +++ + ELEL+ GR+ E A ++
Sbjct: 1944 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 2003
Query: 197 EASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGR------ENRRLQDLATQLQEK 250
+R +R EE Q+ S E + +A E+ R E RRL++ A Q +
Sbjct: 2004 AEEERRRREAEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2061
Query: 251 HHRISLE------YSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEAL 304
+++ E +E + + + K E++ T++ Q +++LR + + EA
Sbjct: 2062 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2121
Query: 305 EQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAEL-QGA 363
E + + + Q +++ E L EE + A EKL+ E Q A
Sbjct: 2122 E--------ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2173
Query: 364 VRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSH 423
R + + ALR ++ + M + ++L+ K Q+++ L T
Sbjct: 2174 ARRAQAEQAALRQ------KQAADAEM--EKHKKFAEQTLRQKAQVEQE----LTTLRLQ 2221
Query: 424 LRHIEHMES---DELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPIN 480
L +H ++ +EL ++L+ E + +QV +E +R++ E+ ++ I
Sbjct: 2222 LEETDHQKNLLDEEL---QRLKAEATEAARQRSQVEEELFSVRVQMEE---LSKLKARIE 2275
Query: 481 REMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGV 540
E R LI + K + QR+ ++ E ++ + A+ S +A L + +
Sbjct: 2276 AENRALIL-------RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2328
Query: 541 SAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPG-AQGP 599
+ E+ + + + +E+ +ED + + A+
Sbjct: 2329 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2388
Query: 600 SSRGREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAEL 659
R EA +R+L + A+R K +V E R ++ + +
Sbjct: 2389 QGFQRTLEAERQRQLEMS--------------AEAERLKLRVAEMSRAQARAEEDAQRFR 2434
Query: 660 KKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERK-AKAEVDELRSRIRELEERDRRES 718
K+A+E ++ L + A +E+ VQ + +R+ + + + LR I ELE RE
Sbjct: 2435 KQAEEIGEK----LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE----REK 2486
Query: 719 KKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQ 778
+K+ E L +++ E Q ++ L T+ +++ LSE D Q ++++ +L Q
Sbjct: 2487 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2546
Query: 779 LREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERAL 838
++ E KA Q+ + + ++ ++ ++ L + ++ + EE R
Sbjct: 2547 FQD----------EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2596
Query: 839 QGSLGGVEKELTLRSQALELNKRKAVEAAQLAED----LKVQLEHVQTRLREIQPCLAES 894
Q L +E++ + + L ++ E QL E+ E V L
Sbjct: 2597 QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2656
Query: 895 RAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQ 936
R A + + + + LRRK+ QR E + E LQ
Sbjct: 2657 RDALDGPAAEAE-PEHSFDGLRRKVSAQRLQEAGILSAEELQ 2697
Score = 76.3 bits (186), Expect = 1e-13
Identities = 154/802 (19%), Positives = 309/802 (38%), Gaps = 97/802 (12%)
Query: 19 EKKLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNKKLAERLEQRQACEDELRERIE 78
+K L+ EE+ R + E + KV + + +L ER EQ A + +L + E
Sbjct: 2018 QKSLAAEEEAARQ-----RKAALEEVERLKAKVEEAR--RLRERAEQESARQLQLAQ--E 2068
Query: 79 KLEKR-QATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDGTP 137
+KR QA + A V + +L +T+ Q E S + G E
Sbjct: 2069 AAQKRLQAEEKAHAFAVQQKEQELQQTL---------QQEQSVLDQLRGEAEAARRAAEE 2119
Query: 138 LPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELELQGRMEFSKAAVSRVVE 197
E R+ Q R + E L S+ E+ + Q + K E
Sbjct: 2120 AEEARVQAEREAA--QSRRQVEEAE-----RLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2172
Query: 198 ASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRISLE 257
A+ R Q L Q+ + + E + A+ R+ + + L L QL+E H+ +L
Sbjct: 2173 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2232
Query: 258 YSELQDKVTSAETKVLEMETTVEDLQW-------DIEKLRKREQKLNKHLAEALEQLNSG 310
ELQ ++ + T+ + VE+ + ++ KL+ R + N+ L ++ N+
Sbjct: 2233 DEELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI-LRDKDNTQ 2290
Query: 311 YYVSGSSSGF-----QGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVR 365
++ + + +++++ Q+ L EE +LA R A EK+ E AV+
Sbjct: 2291 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE--DLAQQR-ALAEKMLKEKMQAVQ 2347
Query: 366 TNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQL-DEARGLLLATKNSHL 424
RLK L + + + Q Q L + Q+ QL +E +G +
Sbjct: 2348 EATRLKAEAELLQQ-------QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2400
Query: 425 RHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMR 484
R +E E +L+ V ++ A+ ++ + R + E+ + +E
Sbjct: 2401 RQLEMSAEAE-----RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2455
Query: 485 HLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPA 544
L+ +L+ Q DA+R + + E++ E KL+ +A + + + +
Sbjct: 2456 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET 2515
Query: 545 PGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGR 604
++ + R+ ++E E+ FQ AQ + R
Sbjct: 2516 QALQQSFLSEKDSLLQRERFI-------------EQEKAKLEQLFQDEVAKAQ----QLR 2558
Query: 605 EPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAELKKAQE 664
E + R ++++ + R A +EE +R++ E +G+R + ++ Q+
Sbjct: 2559 EEQQRQQQQMEQER----------------QRLVASMEEARRRQHEAEEGVRRKQEELQQ 2602
Query: 665 SQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADE 724
+++ + ++ + R+++QL+ + +A E + + + + D
Sbjct: 2603 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDG 2662
Query: 725 DALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDD 784
A + E + L+RK+ A + +E +LS ++ A Q + +L ++D
Sbjct: 2663 PAAE--AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA------QGHTTVDELARRED 2714
Query: 785 ANFKLMSERIKANQIHKLLREE 806
L A + K E+
Sbjct: 2715 VRHYLQGRSSIAGLLLKATNEK 2736
Score = 74.7 bits (182), Expect = 4e-13
Identities = 209/1050 (19%), Positives = 386/1050 (36%), Gaps = 179/1050 (17%)
Query: 19 EKKLSREEKTTTTLIEPIRLGGISSTEEM-DLKVLQFKNKKLAERLEQRQACEDELRERI 77
E + +RE++ +E +RL + + +V + + ++A QR A E EL+ +
Sbjct: 1551 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA-EAELQSKR 1609
Query: 78 EKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDGTP 137
++ A + +L + AQL E E R + Q E A E +
Sbjct: 1610 ASFAEKTAQLERSLQEEHVAVAQLREEAE---RRAQQQAEAERAREEAEREL-------- 1658
Query: 138 LPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELELQGRMEFSKAAVSRVVE 197
E + + L ++L+ + A EE E E + R + + AV +
Sbjct: 1659 --ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1716
Query: 198 ASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRISLE 257
A L++ QR + G ++ A Q E RL+ Q +++ + E
Sbjct: 1717 AEQELEK------QRQLAEGTAQQRLAAEQ--------ELIRLRAETEQGEQQRQLLEEE 1762
Query: 258 YSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSS 317
+ LQ + +A K E+E ++ K+R + L A A E+ S S
Sbjct: 1763 LARLQREAAAATQKRQELEA-------ELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1815
Query: 318 SGFQGGQITLSMQKFEMLNAELEEN-------QELANSRMAELEKLQAELQGAVRTNERL 370
+ G+ ++ L A EE +E A + AE E++ AE A+ RL
Sbjct: 1816 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1875
Query: 371 KVALRSLPEEVVRETGEYRMLQA----QFSLLYNESLQVKTQLDEARGLLLATKNSHLRH 426
K +E E R L Q L ++ Q K ++E L +S L
Sbjct: 1876 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1935
Query: 427 IEHMESDELGLQKKLRTEVIQL-------------------------EDTLA-------- 453
+ + D L ++++ E++ L EDTL
Sbjct: 1936 QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELE 1995
Query: 454 -----QVRKEYEMLRIEFEQ----NLAANEQAGPINREMRHLISSLQ---NHNHQLKGDA 501
Q+ E E R E E+ +LAA E+A + + L+ +L+ A
Sbjct: 1996 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2055
Query: 502 QRYKRKLREVQAEIGKLRAQASGSAHSTP--------NLGHPEDSGVSAPAPGKEEGGPG 553
++ + ++ E + R QA AH+ ++ V G+ E
Sbjct: 2056 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2115
Query: 554 PVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRE 613
+ + A + + E L S E+ AQ + + R+ +
Sbjct: 2116 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2175
Query: 614 LREREGPSLGPPPVASA--------LSRADREKAKVEET--------------KRKESEL 651
+ E +L A A + R+KA+VE+ K E
Sbjct: 2176 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2235
Query: 652 LKGLRAELKKA--QESQKEMKLLL---------------------------DMYKSAPKE 682
L+ L+AE +A Q SQ E +L D + +E
Sbjct: 2236 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2295
Query: 683 QRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQR 742
+ +K++ +A E + + +R+R+L E D + + +A E L+ QA ++ L
Sbjct: 2296 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA-EKMLKEKMQAVQEATRL-- 2352
Query: 743 KLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKL 802
K E E L + ++ + +QE ++ QQL E+ + +
Sbjct: 2353 -----KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE--------- 2398
Query: 803 LREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRK 862
R+ + E+ + LK +V + EE + + +E+ + EL ++
Sbjct: 2399 -RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ----AEEIGEKLHRTELATQE 2453
Query: 863 AVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRK--LE 920
V Q E + Q +H RLRE L + ++E+ L+ E++ ++++ L+
Sbjct: 2454 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQ 2513
Query: 921 KQRKVE--VYADADEILQEE--IKEYKARL 946
+ + ++ ++ D +LQ E I++ KA+L
Sbjct: 2514 ETQALQQSFLSEKDSLLQRERFIEQEKAKL 2543
Score = 55.8 bits (133), Expect = 2e-07
Identities = 129/664 (19%), Positives = 256/664 (38%), Gaps = 70/664 (10%)
Query: 16 GPPEKKLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNKKLAERLEQRQACEDELRE 75
G E E+ ++ R S + + + L+ ++ A+ Q QA ++LR+
Sbjct: 2108 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2167
Query: 76 RIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDG 135
E+ R+A + L + + +A + H+ E + +A QE T
Sbjct: 2168 EAEQEAARRAQAEQAAL-------RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2220
Query: 136 TPLPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELE----LQGRMEFSKAA 191
L D L +L+ +E A S V++E L+ R+E A
Sbjct: 2221 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2280
Query: 192 VSRVVEASDRLQRRVEELCQRVYSRGDSEP-LSEAAQ--AHTRELGRENRRLQDLATQLQ 248
+ ++ D QR ++E +++ + LS AAQ A R+L E DLA Q
Sbjct: 2281 L--ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE-----DLAQQRA 2333
Query: 249 EKHHRISLEYSELQDKVT-SAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQL 307
+ + +Q+ AE ++L+ + E Q +L++ ++++ + LAE +
Sbjct: 2334 LAEKMLKEKMQAVQEATRLKAEAELLQQQK--ELAQEQARRLQEDKEQMAQQLAEETQGF 2391
Query: 308 NSGYYVSGSSS---GFQGGQITLSMQKFEMLNAELEEN------------QELANSRMAE 352
+ ++ L + + A EE+ ++L + +A
Sbjct: 2392 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2451
Query: 353 LEK------LQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVK 406
EK L+ + Q + ERL+ A+ L E + E ++LQ + + +++Q +
Sbjct: 2452 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM--QTVQQE 2509
Query: 407 TQLDEARGL---LLATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLR 463
L E + L L+ K+S L+ +E ++ L++ + EV + + + +++ + +
Sbjct: 2510 QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2569
Query: 464 IEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQAS 523
E ++ +A+ E+A E + Q QL+ ++ + L E + + + Q
Sbjct: 2570 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL-REQLQLL 2628
Query: 524 GSAHSTPNLGHPEDSGVSAPA-----PGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVK 578
H L H E+ S A P + GP + + G ++ +
Sbjct: 2629 EEQHRAA-LAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQR 2684
Query: 579 KEEL-VPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVASALSRADRE 637
+E + S E+ Q + G R + R + G +A L +A E
Sbjct: 2685 LQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQ---------GRSSIAGLLLKATNE 2735
Query: 638 KAKV 641
K V
Sbjct: 2736 KLSV 2739
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 104 bits (260), Expect = 4e-22
Identities = 211/1050 (20%), Positives = 401/1050 (38%), Gaps = 193/1050 (18%)
Query: 46 EMDLKVLQFKN------KKLAERLEQRQACEDELRERIEKL--EKRQATDDATLLIVNRY 97
E++ K+L + KKL E L R+A + +E+ L E +Q DD NR
Sbjct: 1161 ELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDD-----YNRL 1215
Query: 98 WAQLDE------TVEALLRCHESQGELSSAPEAPGTQEGPTCDGTP-LPEP--------G 142
Q DE + LR + Q S + P T + +C TP L EP
Sbjct: 1216 QEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHH 1275
Query: 143 TSELRDPLLMQLRPPLSEPALAFV---------VALGASSSEEVELELQGRMEFSKAA-- 191
T + + L P SE A A L +E+VELEL+ S+
Sbjct: 1276 TQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKK 1335
Query: 192 ---VSRVVEASDRLQRRVEEL----------CQRVYSRGDSEPLSEAAQAHTRELGRENR 238
V ++ E ++ +E L + + + +S L A H REL +
Sbjct: 1336 SEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLD 1395
Query: 239 RLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQWDIE----------- 287
LQ L ++ +E +S + SE + +T +T+++E E ++ L +E
Sbjct: 1396 ELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIK 1455
Query: 288 ----------------------------KL------RKREQKLNKHLAEAL-------EQ 306
KL RK K NK L E L E+
Sbjct: 1456 QLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIER 1515
Query: 307 LNSGYYVSGSSSGFQG-------GQITLSMQKFEMLNAELE----ENQELANSRMAELEK 355
L S Q G++ L ++ + L E++ ENQ L++S E
Sbjct: 1516 LTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSS----CES 1571
Query: 356 LQAELQGAVRTNERLKVALRSLPEEVVRETGEY----RMLQAQFSLLYNESLQVKTQLDE 411
L+ L+G E+L + SL + E+ E+ + LQ ++ +L V + +
Sbjct: 1572 LKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAER 1631
Query: 412 ARGLLLATKNSHLR---HIEHMESDELGLQKKLRTEVIQLEDTLAQVRK-----EYEMLR 463
+ ++ A + + E+++ +K+L+ ++E+ ++RK + ++L
Sbjct: 1632 IQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILE 1691
Query: 464 IEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQAS 523
+E E+N + P + + +L + N +K + +R K + + + L ++
Sbjct: 1692 LE-EENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKD 1750
Query: 524 GSAHSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELV 583
+ +L H + VS ++ DN+ T + + + +
Sbjct: 1751 SLSEEVQDLKHQIEGNVS------KQANLEATEKHDNQ-----------TNVTEEGTQSI 1793
Query: 584 PSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVASALSRADREKAKV-- 641
P E + Q + P+ P A+ ++ S + + L + D+ K ++
Sbjct: 1794 PGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSS--HDEINNYLQQIDQLKERIAG 1851
Query: 642 -EETKRKESELLKGLRAE----LKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKA 696
EE K+K E + L E L + E+K+L +E+ K+ L+
Sbjct: 1852 LEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKML--------QEEVTKMNLL------ 1897
Query: 697 KAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLS 756
++ E SR+ +L+E E K +E + ++ + I + + + + + E L S
Sbjct: 1898 NQQIQEELSRVTKLKET-AEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLES 1956
Query: 757 EMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLG 816
EM + +++E+ +L+++ + + K E+I+ Q + EL E +
Sbjct: 1957 EMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKE 2016
Query: 817 LKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQ 876
+ +V + +EK AL+ ++ +E T + LE+ K +A + + + +
Sbjct: 2017 KQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAE 2076
Query: 877 LEHVQTRLREIQPCLA-----------ESRAAREKESFNLKRAQEDISR---------LR 916
L + L + Q A E ++ +E +K+ ED+ R L+
Sbjct: 2077 LASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLK 2136
Query: 917 RKLEKQRKVEVYADADEILQEEIKEYKARL 946
K Q K++ L+E I E + L
Sbjct: 2137 EKKNMQEKLDALRREKVHLEETIGEIQVTL 2166
Score = 87.8 bits (216), Expect = 5e-17
Identities = 193/1028 (18%), Positives = 434/1028 (42%), Gaps = 144/1028 (14%)
Query: 19 EKKLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNKKLA-----------ERLEQRQ 67
EK+L E+ + E +R + +++ + L+ +N +L E +E
Sbjct: 1661 EKQLQEAEQEMEEMKEKMRK--FAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLL 1718
Query: 68 ACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSS-----AP 122
+ ++E +E+++ T + L E V+ L H+ +G +S A
Sbjct: 1719 SSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLK--HQIEGNVSKQANLEAT 1776
Query: 123 EAPGTQEGPTCDGTPLPEPGTSELRDPLLMQLRPPLSEPALAF-----VVALGASSSEEV 177
E Q T +GT PG +E +D L M RP SE + V+ SS +E+
Sbjct: 1777 EKHDNQTNVTEEGTQ-SIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEI 1835
Query: 178 EL------ELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYSR-GDSEPLSEAA---- 226
+L+ R+ + + E S L+ L ++ ++ G+ + L E
Sbjct: 1836 NNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMN 1895
Query: 227 ---QAHTRELGRENRRLQDLATQLQEKHHRISLEYSELQ-------DKVTSAETKVLEME 276
Q EL R + + + + R+ + +EL VT A+ K +E
Sbjct: 1896 LLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLE 1955
Query: 277 TTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLN 336
+ +++L+ + +L + +Q+L K + ++ Y + + G + + + E+L
Sbjct: 1956 SEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLK 2015
Query: 337 AELEENQELANSRMAELEKLQAELQGAVR--------TNERLKVALRSLPEEVVR----- 383
+ +E ++L + EK+ A L+ V+ + + L++ +L + V
Sbjct: 2016 EKQQEVKQLQKDCIRYQEKISA-LERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQ 2074
Query: 384 -ETGEYRML----QAQFSLLYNESLQVKTQLD---EARGLLLATKNSHL-RHIEHMESDE 434
E +++L Q++ + + ++L++K +L E+ + K+ L R +E E
Sbjct: 2075 AELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKH 2134
Query: 435 L----GLQKK---LRTEVIQLEDTLAQV-----RKEYEMLRIEFEQNLAAN-EQAGPINR 481
L +Q+K LR E + LE+T+ ++ +K+ E+ ++ ++NL + Q +
Sbjct: 2135 LKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQL--QENLDSTVTQLAAFTK 2192
Query: 482 EMRHLISSLQNHNHQLKGDAQRYKRKLRE-VQAEIGKLRAQASGSAHSTPNLG----HPE 536
M SSLQ+ ++ +A++++RK + +Q++ ++R + + L H E
Sbjct: 2193 SM----SSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHME 2248
Query: 537 DSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTT--------TTSVKKEELVPSEED 588
+ ++ +S ++ K++ T T + +EL+ E+
Sbjct: 2249 ELKIN-------------ISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEE 2295
Query: 589 FQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKE 648
+ + +Q ++ K +L + ++++L + +K +E R++
Sbjct: 2296 TRHLYHSSQNELAKLESELKSLKDQLTD----------LSNSLEKCKEQKGNLEGIIRQQ 2345
Query: 649 SELLKGLRAELKKAQ-ESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKA-KAEVDELRSR 706
++ + ++ + + Q +L +++ +++ + L++ + +A + + ELR +
Sbjct: 2346 EADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQ 2405
Query: 707 ----IRELEE-RDRRESKKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVT 761
I+ELE + E + I E+ ++A ++ L L K+E +++D
Sbjct: 2406 HDKEIKELENLLSQEEEENIVLEE---ENKKAVDKTNQLMETLKTIKKENIQQKAQLDSF 2462
Query: 762 GQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQV 821
++ +Q R++ ++ ++ + ++ E+ +Q+ + E ++L E++ GL+S +
Sbjct: 2463 VKSMSSLQNDRDRIVGDYQQLEERHLSIILEK---DQLIQEAAAENNKLKEEIRGLRSHM 2519
Query: 822 DAQLLTVQKLEEKERALQGSLGGV-----EKELTLRSQALELNKRKAVEAAQLAEDLKVQ 876
D KL+ + + L V ++ L L+ NK + A+L E LK +
Sbjct: 2520 DDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLK-E 2578
Query: 877 LEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQ 936
E LR L E + KE +LK + ++R L+++ + +Y ++ +
Sbjct: 2579 SEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKE 2638
Query: 937 EEIKEYKA 944
EE+ A
Sbjct: 2639 EEVHRLSA 2646
Score = 80.9 bits (198), Expect = 6e-15
Identities = 178/895 (19%), Positives = 353/895 (39%), Gaps = 143/895 (15%)
Query: 144 SELRDPLLMQLRPPLSEPALAFVVALGASSSEE----VELELQGRMEFSKAAV------- 192
SE RD LL Q++ L+ V L A + E E Q R+++
Sbjct: 743 SEERDQLLSQVKE------LSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTE 796
Query: 193 ---SRVVEASDR------LQRRVEELCQRVYSRGDS--EPLSEAAQAHTRELGRENRRLQ 241
S +EA + LQ ++++ Q +S + L Q E+ R++
Sbjct: 797 QIHSLSIEAKSKDVKIEVLQNELDDV-QLQFSEQSTLIRSLQSQLQNKESEVLEGAERVR 855
Query: 242 DLATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLA 301
++++++E +S S+ + ++T + +LE + VE LQ IE+ ++ +++ +
Sbjct: 856 HISSKVEE----LSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMT 911
Query: 302 EALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELAN-----------SRM 350
E + QLN + G Q+ L + E ++EE+ E+++ +
Sbjct: 912 EKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQ 971
Query: 351 AELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLD 410
E+LQ E + NE+ K L++ L+ + + L +ES + +
Sbjct: 972 ISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSE 1031
Query: 411 EARGLLLATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNL 470
RG + K E+ E E + K + I L+ T+++ E + +R + E+ L
Sbjct: 1032 TERGEVEEDK-------ENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKL 1084
Query: 471 AANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTP 530
AA EQ + ++M +LQ+ +Q+ + ++ E QA I KL + ++
Sbjct: 1085 AAEEQFQALVKQMN---QTLQDKTNQI----DLLQAEISENQAIIQKLITSNTDASDGDS 1137
Query: 531 NLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQ 590
E +S P G E P +KE+L ++ Q
Sbjct: 1138 VALVKETVVISPPCTGSSE-------------HWKPELEEKILALEKEKEQL---QKKLQ 1181
Query: 591 GITPGAQGPSSRGREPEARPKRELRE----------------REGPSLGPPPVASALSRA 634
+ + +E E + EL++ +E ++G +
Sbjct: 1182 EALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVR 1241
Query: 635 DREKAKVEETKRKES-ELLKGLRAELKKAQESQKEMKLL--------------------- 672
+ K+ T ++ES GL L KA E +L
Sbjct: 1242 ESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGG 1301
Query: 673 --LDMYKSAPKE-QRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADEDALRR 729
+ K+ KE + +KV+L E K + EL + E+ + + +K+ + ++L+
Sbjct: 1302 TSVAQIKAQLKEIEAEKVEL---ELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKT 1358
Query: 730 I-RQAEEQIEHLQRKLGATK------QEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREK 782
+ +AE E LQ+KL +++ + L ++D + +E L QL EK
Sbjct: 1359 VSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEK 1418
Query: 783 DDANFKLMSERIKANQ----IHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERAL 838
+ A K+ +E I+ +H L + E E++ L+ ++ +++ E+ RA
Sbjct: 1419 EAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAK 1478
Query: 839 QGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKV---QLEHVQTRLREIQPCLAESR 895
Q ++ L R +AL+ NK L E+L + +E + L +++ ++
Sbjct: 1479 QQIQRKLQAALISRKEALKENK-------SLQEELSLARGTIERLTKSLADVESQVSAQN 1531
Query: 896 AAREKESFNLKRAQED----ISRLRRKLEKQRKVEVYADADEILQEEIKEYKARL 946
++ L QE+ I+ + R L + + + ++ ++ E + E K +L
Sbjct: 1532 KEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKL 1586
Score = 80.5 bits (197), Expect = 7e-15
Identities = 179/938 (19%), Positives = 368/938 (39%), Gaps = 120/938 (12%)
Query: 19 EKKLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNKKLAERLEQRQACEDELRERIE 78
E+K EE+ L E L G D+ Q KN+ L ++ + C EL E +
Sbjct: 1917 EEKDDLEERLMNQLAE---LNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQ 1973
Query: 79 KLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDGTPL 138
+L K + ++ + E +E + + G S A E QE L
Sbjct: 1974 QLVKEKTKVESEIR---------KEYLEKIQGAQKEPGNKSHAKEL---QE--------L 2013
Query: 139 PEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELELQGRMEFSKAAVSRVVEA 198
+ E++ +R AL V + E V+ E Q +E +K +++ VE
Sbjct: 2014 LKEKQQEVKQLQKDCIRYQEKISALERTV----KALEFVQTESQKDLEITKENLAQAVEH 2069
Query: 199 SDRLQRRVEEL--------CQRVYSRGDSEPLSEAAQAHTRELGRENRRL-QDLATQLQE 249
+ Q + + D+ L + Q++ + + ++ +DL +L++
Sbjct: 2070 RKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQ 2129
Query: 250 KHHRISLEYSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNS 309
+ E +Q+K+ + + + +E T+ ++Q + K K Q+L ++L + QL +
Sbjct: 2130 AEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQL-A 2188
Query: 310 GYYVSGSSSGFQGGQITLSMQKFE-MLNAELEENQELANSRMAELEKLQAELQGAVRTNE 368
+ S SS ++ +K+E + ++ +E + L+ +L+ E
Sbjct: 2189 AFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHME 2248
Query: 369 RLKVALRSLPEE----VVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKN--- 421
LK+ + L + + E ++ Q L E+ ++ +QL+E R L +++N
Sbjct: 2249 ELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELA 2308
Query: 422 ---SHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGP 478
S L+ ++ +D +K + + LE + Q + + + +EQ L + QA
Sbjct: 2309 KLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQ-LETDLQAS- 2366
Query: 479 INREMRHLISSLQNH-NHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPED 537
R L S L N + + K +Q I +LR Q NL E+
Sbjct: 2367 -----RELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEE 2421
Query: 538 SGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQ 597
V +N+K + T ++KKE + + + +
Sbjct: 2422 E-------------ENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVK--SM 2466
Query: 598 GPSSRGREPEARPKRELREREGPSLGPPPVASALSRADR--EKAKVEETKRKESELLKGL 655
R+ ++L ER S + D+ ++A E K KE ++GL
Sbjct: 2467 SSLQNDRDRIVGDYQQLEERH---------LSIILEKDQLIQEAAAENNKLKEE--IRGL 2515
Query: 656 RAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDR 715
R+ + ++ L Y+ ++ + + +++K EV +L++
Sbjct: 2516 RSHMDDLNSENAKLDAELIQYR---EDLNQVITIKDSQQKQLLEV--------QLQQNKE 2564
Query: 716 RESKKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRL 775
E+K E+ +++++EE E L+R A ++E++ L E++ + + Q
Sbjct: 2565 LENKYAKLEE---KLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQ---- 2617
Query: 776 LQQLREKDDANFKLMSERIKANQIHKL------LREEKDELGEQVLGLKSQVDAQLLTVQ 829
+ L+E+ ++K ++H+L ++ EL E+++ ++ + +
Sbjct: 2618 VTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKE------AAK 2671
Query: 830 KLEEKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQP 889
K+ E E L+ L + + + E + + A+LA DL + + +E +
Sbjct: 2672 KVGEIEDKLKKELKHLHHDAGIMRNETETAEER---VAELARDLVEMEQKLLMVTKENKG 2728
Query: 890 CLAESRA-AREKESFNLKR--AQEDISRLRRKLEKQRK 924
A+ ++ R S R A E++ L+RK + K
Sbjct: 2729 LTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLK 2766
Score = 74.7 bits (182), Expect = 4e-13
Identities = 197/970 (20%), Positives = 383/970 (39%), Gaps = 151/970 (15%)
Query: 41 ISSTEEMDLKVLQFKNKKLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQ 100
++ E++ +++ +K + ++ +A ++E + K++K + A L +N+Y +
Sbjct: 54 LAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEE 113
Query: 101 LDETVEALLRCHESQGELSSAPEAPGTQEGPTCDGTPLPEPGTSELRDPLLMQLRPPLSE 160
+ +L E S + T+E + EL L QL +E
Sbjct: 114 MKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAE 173
Query: 161 PALAFVVALGASSSEEVE------LELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVY 214
A SS E+E +LQ + EF +++ Q + E+ Q+V
Sbjct: 174 QP--------AQSSTEMEEFVMMKQQLQEKEEFISTLQAQL------SQTQAEQAAQQVV 219
Query: 215 SRGDSEPLSEAAQAHTRELGRENRRLQ-----DLATQLQEKHHRISLEYSELQDKVTSAE 269
D A+ T+ E+ LQ D+ T++Q+K LQ K+ E
Sbjct: 220 REKD-------ARFETQVRLHEDELLQLVTQADVETEMQQK-------LRVLQRKLEEHE 265
Query: 270 TKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSM 329
++ V+ LQ ++ +R N+ L++ L+Q+ + + ++ + + + +
Sbjct: 266 ESLVGRAQVVDLLQQELTAAEQR----NQILSQQLQQMEAEHNTLRNTVETEREESKILL 321
Query: 330 QKFEMLNAELEENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYR 389
+K E+ E+ E + ++ E+ L + + A + L+ +L ++ E E
Sbjct: 322 EKMEL---EVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEE-- 376
Query: 390 MLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHLRHIEHMESDELGLQKKLRTEVIQLE 449
+ SLQ Q ++ L +NS L + +E +Q + QLE
Sbjct: 377 ------KTSHILSLQKTGQELQSACDALKDQNSKLL----QDKNEQAVQS--AQTIQQLE 424
Query: 450 DTLAQVRKEYEML--RIEFEQNLAANEQAGP------INREMRHLISSLQNHNHQL---K 498
D L Q KE R+ +Q+ A++ + P I+SLQ +L K
Sbjct: 425 DQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEK 484
Query: 499 GDAQRYKRKLREVQAEIGKLRAQAS-GSAHSTPNLGHPEDSGVS------APAPGKEEGG 551
G +L E++AE KL +Q + A + E S +S + EE G
Sbjct: 485 GALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESG 544
Query: 552 PGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPK 611
+ ++K SV E+ ++E+ + QG + + E +
Sbjct: 545 QDVLENTFSQKH---------KELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQ 595
Query: 612 RELREREGPSLGP-----------------PPVASALSRADREKAKVEETKRKESEL-LK 653
+E+++ EG + P P S+L ++E+A E R E+ L
Sbjct: 596 KEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLN 655
Query: 654 GLRAELKKA-QESQKEMKLLLDMYKSAPKE-QRDKVQLMAAERKAKAEVDELRSRIRELE 711
ELK Q+ K + + D+ + E +R K Q++ E++ + +E+
Sbjct: 656 DAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQIL--------ELELNFHKAQEIY 707
Query: 712 ERDRRE-SKKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQE 770
E++ E +K+I++ + L I + ++ ++ A +E + LLS++ E ++
Sbjct: 708 EKNLDEKAKEISNLNQL--IEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTE-LRA 764
Query: 771 QNGRLLQQLREKD-----DANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQL 825
Q +L L E + D + + + QIH L E K + ++ L++++D
Sbjct: 765 QVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSK-DVKIEVLQNELDDVQ 823
Query: 826 LTVQKLEEKERALQGSLGGVEKEL-------------------TLRSQALELNK--RKAV 864
L + R+LQ L E E+ L + LE+ K + +
Sbjct: 824 LQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLL 883
Query: 865 EAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNL----KRAQEDISRLRRKLE 920
E + E L+ +E ++ EI + E +E F+L K +E ++ L R E
Sbjct: 884 EKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSR-AE 942
Query: 921 KQRKVEVYAD 930
+ +K +V D
Sbjct: 943 EAKKEQVEED 952
Score = 72.8 bits (177), Expect = 2e-12
Identities = 192/970 (19%), Positives = 372/970 (38%), Gaps = 153/970 (15%)
Query: 52 LQFKNKKLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRC 111
LQ +NK+L +LE+ + + + KLE + QL + +L +C
Sbjct: 2282 LQGENKELLSQLEETRHLYHSSQNELAKLESE----------LKSLKDQLTDLSNSLEKC 2331
Query: 112 HESQGEL--------SSAPEAPGTQEGPTCDGTPLPEPGTSELRDPLLMQLRPPLS---- 159
E +G L + + + E D E TS L + + M+ + +S
Sbjct: 2332 KEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASREL-TSRLHEEINMKEQKIISLLSG 2390
Query: 160 -EPALAFVVALGASSSEEVELELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYSRGD 218
E A+ +A ++ EL+ + + + E + + + +L + + +
Sbjct: 2391 KEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTI-K 2449
Query: 219 SEPLSEAAQAHT-----RELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVL 273
E + + AQ + L + R+ QL+E+H I LE +L + + K+
Sbjct: 2450 KENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLK 2509
Query: 274 EMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFE 333
E + L+ ++ L KL+ L + E LN + S Q+ +
Sbjct: 2510 E---EIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDS-------------QQKQ 2553
Query: 334 MLNAELEENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEE------------- 380
+L +L++N+EL N + KL+ +L+ + NE L+ + +L EE
Sbjct: 2554 LLEVQLQQNKELEN----KYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKV 2609
Query: 381 -VVRETGEYRMLQAQFSL-LYNESLQVKTQLDEARGLLLATKNSHLRHIEHMESDELGLQ 438
+ + T + LQ + +L LY+ L+VK +E L A +S + I +E + + +Q
Sbjct: 2610 SISQLTRQVTALQEEGTLGLYHAQLKVK---EEEVHRLSALFSSSQKRIAELEEELVCVQ 2666
Query: 439 KKLRTEVIQLEDTLAQVRKEYE----MLRIEFEQNLAANEQAGPINREMRHL-------- 486
K+ +V ++ED L + K ++R E E A E+ + R++ +
Sbjct: 2667 KEAAKKVGEIEDKLKKELKHLHHDAGIMRNETE---TAEERVAELARDLVEMEQKLLMVT 2723
Query: 487 ----------------ISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTP 530
+SSLQN + KRK E+ +L+ Q
Sbjct: 2724 KENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGL------- 2776
Query: 531 NLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQ 590
L D+ +S A +S + + S + E+ + F
Sbjct: 2777 -LNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFS 2835
Query: 591 GITPGAQGPSSR--GREPEARPKRELREREG--PSLGPPPVAS---ALSRADREKAK-VE 642
Q + R E ++R PS P V S A+S ++ + ++
Sbjct: 2836 KAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLK 2895
Query: 643 ETKRKESELLK---------GLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAE 693
E K + + L+ L+A+L++ Q+ K +++ + + + ++ + E
Sbjct: 2896 ELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRME 2955
Query: 694 RKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEA 753
K+ E+ E R + + L ++ + ++ +R +R + Q + L K+ +Q
Sbjct: 2956 -KSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPL--KVQYQRQASPE 3012
Query: 754 LLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQ 813
+ D + + + +L L+E ++ + N L EEK+ L Q
Sbjct: 3013 TSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQ----QLNSNFSQLLEEKNTLSIQ 3068
Query: 814 VLGLKSQVDAQLLTVQKLEEKERALQGSLG--GVEKELTLRSQALELNKRKAVEAAQLAE 871
+ T Q L E ++ L V ++ QA LN A A Q E
Sbjct: 3069 LCD----------TSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQ--E 3116
Query: 872 DLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYAD- 930
V + LRE Q +E++ L +++++ LR+ LE++R V A+
Sbjct: 3117 KNGVHRKSDPEELREPQQSFSEAQQ-------QLCNTRQEVNELRKLLEEERDQRVAAEN 3169
Query: 931 ADEILQEEIK 940
A + +E+I+
Sbjct: 3170 ALSVAEEQIR 3179
Score = 72.0 bits (175), Expect = 3e-12
Identities = 178/881 (20%), Positives = 356/881 (40%), Gaps = 142/881 (16%)
Query: 178 ELELQGRMEFSKA-----------AVSRVVEASDRLQRRVEELCQRVYSRGDSEPLSEAA 226
EL + MEF+ A VVE D ++++ +L Q+ E L E
Sbjct: 33 ELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQK------DEALQEER 86
Query: 227 QAHTRELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQWDI 286
+A ++ + + T L + + + + +E ++ + + + + + +I
Sbjct: 87 KAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEI 146
Query: 287 EKLRKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELA 346
EK++ + Q+ + ++ QL + Q Q + M++F M+ +L+E +E
Sbjct: 147 EKIKHKLQEKEELISTLQAQLTQ-------AQAEQPAQSSTEMEEFVMMKQQLQEKEEFI 199
Query: 347 NSRMAELEKLQAE--LQGAVRTNE-RLKVALRSLPEEVVR-------ET---GEYRMLQA 393
++ A+L + QAE Q VR + R + +R +E+++ ET + R+LQ
Sbjct: 200 STLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQR 259
Query: 394 QFSLLYNESLQVKTQLDE--ARGLLLATKNSHL--RHIEHMESDELGLQKKLRTE----- 444
+ + ESL + Q+ + + L A + + + + ++ ME++ L+ + TE
Sbjct: 260 KLE-EHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESK 318
Query: 445 --VIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISSL-QNHNHQLKGDA 501
+ ++E +A+ + + L+ E L EQAG E+ S+L Q H +++
Sbjct: 319 ILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKT 378
Query: 502 QR---YKRKLREVQAEIGKLRAQAS--------GSAHSTPNLGHPED---------SGVS 541
++ +E+Q+ L+ Q S + S + ED S
Sbjct: 379 SHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFL 438
Query: 542 APAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTT-------------TSVKKEELVPSEED 588
P ++ S PD E GT T +K L+ S +
Sbjct: 439 NRLPLQQHETASQTSFPDVYNE-----GTQAVTEENIASLQKRVVELENEKGALLLSSIE 493
Query: 589 FQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVASALSRADREKAK--VEETKR 646
+ + + SS+ EA+ + +RE + +A+ S + E + +E T
Sbjct: 494 LEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFS 553
Query: 647 KESELLKGLRAELKKAQESQKEMKLLLD--MYKSAPKEQRDKVQLMAAERKAKAEVDELR 704
++ + L L E+K+AQE +KL L + A E D+ ++ E + A + +
Sbjct: 554 QKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPI---K 610
Query: 705 SRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQR------------KLGATKQEEE 752
++ LE+ + +E +L + + + EH R +L +TKQ+ +
Sbjct: 611 MKV-FLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGD 669
Query: 753 ALLSEMDVTGQAFEDMQEQ----------NGRLLQQLRE-------KDDANFKLMSERIK 795
LS + GQ +D E+ N Q++ E K+ +N + E K
Sbjct: 670 KSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFK 729
Query: 796 AN-----QIHKLLREEKDELGEQ------VLGLKSQVDAQLLTVQKLEEKERALQGSLGG 844
N L EE+D+L Q V L++QV + + + E + R S
Sbjct: 730 KNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTA 789
Query: 845 VEKELTLRSQALELN-KRKAVEAAQL---AEDLKVQLEHVQTRLREIQPCLAESRAAREK 900
+ LT + +L + K K V+ L +D+++Q T +R +Q L + +
Sbjct: 790 HDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLE 849
Query: 901 ESFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQEEIKE 941
+ ++ + L + L Q+++E+ D++L E+ ++
Sbjct: 850 GAERVRHISSKVEELSQAL-SQKELEI-TKMDQLLLEKKRD 888
Score = 50.4 bits (119), Expect = 8e-06
Identities = 67/301 (22%), Positives = 132/301 (43%), Gaps = 22/301 (7%)
Query: 660 KKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESK 719
K Q QK+ L + + K ++ K+ A ++E++++ + + + +
Sbjct: 71 KDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEE 130
Query: 720 KIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVT---GQAFEDMQ-----EQ 771
+++ D + + E +IE ++ KL QE+E L+S + QA + Q E+
Sbjct: 131 QLSKHD--KSSTEEEMEIEKIKHKL----QEKEELISTLQAQLTQAQAEQPAQSSTEMEE 184
Query: 772 NGRLLQQLREKDDANFKLMSE--RIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQ 829
+ QQL+EK++ L ++ + +A Q + + EKD E + L QL+T
Sbjct: 185 FVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQA 244
Query: 830 KLE----EKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTRLR 885
+E +K R LQ L E+ L R+Q ++L +++ A Q + L QL+ ++
Sbjct: 245 DVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHN 304
Query: 886 EIQPCLAESRAARE--KESFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQEEIKEYK 943
++ + R + E L+ A+ +S + E +E + A + E Y
Sbjct: 305 TLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYS 364
Query: 944 A 944
A
Sbjct: 365 A 365
Score = 40.8 bits (94), Expect = 0.006
Identities = 61/248 (24%), Positives = 99/248 (39%), Gaps = 40/248 (16%)
Query: 203 QRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRISLEYSELQ 262
+RR++E Q + + D + Q REL + + Q L Q Q + S E S
Sbjct: 2963 ERRMKE--QYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQ---ASPETSASP 3017
Query: 263 DKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSSSGFQG 322
D + + + T + D +I + R Q+LN + ++ LE+ N
Sbjct: 3018 DGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKN-------------- 3063
Query: 323 GQITLSMQKFEMLNAELEENQELAN---SRMAELEKLQAELQGAV--------RTNERLK 371
TLS+Q + + L ENQ+ + A LEK ELQ E+
Sbjct: 3064 ---TLSIQLCD-TSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNG 3119
Query: 372 VALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNS------HLR 425
V +S PEE+ + Q Q E +++ L+E R +A +N+ +R
Sbjct: 3120 VHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIR 3179
Query: 426 HIEHMESD 433
+EH E D
Sbjct: 3180 RLEHSEWD 3187
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 101 bits (252), Expect = 3e-21
Identities = 191/958 (19%), Positives = 376/958 (39%), Gaps = 110/958 (11%)
Query: 41 ISSTEEMDLKVLQFKNKKLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQ 100
+ EEM+ + L K +KL + + + D+L + K+EK + + + + A
Sbjct: 926 LEDEEEMNAE-LTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAG 984
Query: 101 LDETVEALLRCHESQGELSSAPEAPGTQEGPTCDGTPLPEPGTSELRDPLLMQLRPPLSE 160
LDE + L + E QE + D L + E
Sbjct: 985 LDEIIAKLTK------------EKKALQEAH------------QQALDDLQAE------E 1014
Query: 161 PALAFVVALGASSSEEVELELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYS-RGDS 219
+ + ++V+ +L+G +E K + A +L+ ++ + + D
Sbjct: 1015 DKVNTLTKAKVKLEQQVD-DLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDK 1073
Query: 220 EPLSEAAQAHTRELGRENRRLQD---LATQLQEKHHRISLEYSELQDKVTSAETKVLEME 276
+ L E + EL N R++D L +QLQ+K + EL++++ + T ++E
Sbjct: 1074 QQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVE 1133
Query: 277 TTVEDLQWDIEKL------------------RKRE---QKLNKHLAEALEQ-------LN 308
DL ++E++ +KRE QK+ + L EA Q L
Sbjct: 1134 KLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALR 1193
Query: 309 SGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVRTNE 368
+ S + G Q + QK E +E + + S M ++ K +A L+ RT E
Sbjct: 1194 KKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLE 1253
Query: 369 RLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHLRHIE 428
RS EE R + L +Q + L E+ ++ QLDE L+ L + +
Sbjct: 1254 DQMNEHRSKAEETQRSVND---LTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQ 1310
Query: 429 HMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPI----NREMR 484
+E + L+++++ + L L R + ++LR ++E+ A + + N E+
Sbjct: 1311 QLEDLKRQLEEEVKAK-NALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVA 1369
Query: 485 HLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPA 544
+ + Q + + K+KL + E + + S H + +
Sbjct: 1370 QWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLM 1429
Query: 545 PGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGIT------PGAQG 598
E + ++ + + EL S+++ + ++ A
Sbjct: 1430 VDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYE 1489
Query: 599 PSSRGREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGL-RA 657
S E R + L+E E L +S + + EK + ++ + ++ EL L A
Sbjct: 1490 ESLEHLETFKRENKNLQE-EISDLTEQLGSSGKTIHELEKVR-KQLEAEKMELQSALEEA 1547
Query: 658 ELKKAQESQKEMKLLLDMYKSAPKEQRDKV----QLMAAERKAKAEVDELRSRIRELEER 713
E E K ++ L+ + + +R ++ A+R VD L++ + + E R
Sbjct: 1548 EASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSL-DAETR 1606
Query: 714 DRRES---KKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQE 770
R E+ KK + D + + E Q+ H R +++ ++L S + T +D
Sbjct: 1607 SRNEALRVKKKMEGD----LNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVR 1662
Query: 771 QNGRLLQQLREKDDANFKLMSERIKANQI-------HKLLREEKDELGEQVLGLKSQVDA 823
N L + + + N L +E + + KL +E E E+V L SQ +
Sbjct: 1663 ANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTS 1722
Query: 824 QLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLE---HV 880
+ +K++ LQ VE+ + A E K+ +AA +AE+LK + + H+
Sbjct: 1723 LINQKKKMDADLSQLQTE---VEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1779
Query: 881 QTRLREIQPCLAE-SRAAREKESFNLKRAQEDISRLR---RKLEKQRKVEVYADADEI 934
+ + ++ + + E E LK ++ + +L R+LE + + E +A+ +
Sbjct: 1780 ERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESV 1837
Score = 80.9 bits (198), Expect = 6e-15
Identities = 198/995 (19%), Positives = 407/995 (40%), Gaps = 144/995 (14%)
Query: 52 LQFKNKKLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRC 111
+Q +++ + R+E ++ L ER + L Q A + + N W +L ++ LL+
Sbjct: 788 IQAQSRGVLARMEYKK-----LLERRDSLLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKS 842
Query: 112 HESQGELSSAPEA----PGTQEGPTCDGTPLPEPGTSELRDPLLMQLRPPLSEPALAFV- 166
E + E++S E E L E S L++ +QL+ + LA
Sbjct: 843 AEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAE 902
Query: 167 ----------VALGASSSEEVE-LELQGRMEFSKAAVSRVVEAS-DRLQRRVEELCQRVY 214
+ L A E E LE + M A R +E L+R +++L +
Sbjct: 903 ERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDL-ELTL 961
Query: 215 SRGDSEPLSEAAQAHTRELGRENRRLQDLATQL-------QEKHHRISLEYSELQDKVTS 267
++ + E A + + L E L ++ +L QE H + + +DKV +
Sbjct: 962 AKVEKE--KHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNT 1019
Query: 268 AETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSS-----SGFQG 322
+++E V+DL+ +E +E+K+ L A +L ++ S + Q
Sbjct: 1020 LTKAKVKLEQQVDDLEGSLE----QEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQ 1075
Query: 323 GQITLSMQKFEM--LNAELEENQELANSRMAELEKLQA---ELQGAVRTNERLKVALRSL 377
L + FE+ LNA +E+ Q L + +L++LQA EL+ + + + L
Sbjct: 1076 LDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKL 1135
Query: 378 PEEVVRETGEY--RMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHLRHIEHMESDEL 435
++ RE E R+ +A + + K + E + + + + L+H E+
Sbjct: 1136 RSDLSRELEEISERLEEAGGATSVQIEMNKKREA-EFQKMRRDLEEATLQH----EATAA 1190
Query: 436 GLQKKLRTEVIQLE---DTLAQVRKEYEMLRIEFEQNL----AANEQAGPINREMRHLIS 488
L+KK V +L D L +V+++ E + EF+ L + EQ + +
Sbjct: 1191 ALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCR 1250
Query: 489 SLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPAPGKE 548
+L++ ++ + A+ +R + ++ ++ KL+ + + +++ +S GK
Sbjct: 1251 TLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDE----KEALISQLTRGKL 1306
Query: 549 EGGPGPVSTPDNRKEMAPVPGTTTTTTSVKK----------EELVPSEEDFQGITPGAQG 598
+E + EE ++ + Q + A
Sbjct: 1307 TYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANS 1366
Query: 599 PSSRGR---EPEARPKRELREREGPSLGP--PPVASALSRADREKAKVEETKRKESELLK 653
++ R E +A + E E L A+ + + + +E+TK + ++
Sbjct: 1367 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIE 1426
Query: 654 GLRAELKKA-------QESQKEMKLLLDMYKSAPKEQRDKVQLMAAE-RKAKAEVDELRS 705
L +++++ + Q+ +L +K +E + +++ E R E+ +L++
Sbjct: 1427 DLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKN 1486
Query: 706 RIRE-LE--ERDRRESKKIADE-----DALRRIRQAEEQIEHLQRKLGATKQEEEALLSE 757
E LE E +RE+K + +E + L + ++E ++++L A K E ++ L E
Sbjct: 1487 AYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEE 1546
Query: 758 MDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQ---- 813
+ + ++ + G++L+ +L +IKA KL EKDE EQ
Sbjct: 1547 AEAS------LEHEEGKILRA---------QLEFNQIKAEIERKL--AEKDEEMEQAKRN 1589
Query: 814 ----VLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELT-LRSQALELNKR------- 861
V L++ +DA+ + + ++ ++G L +E +L+ A E K+
Sbjct: 1590 HLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSL 1649
Query: 862 ------KAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRL 915
+ +A + +DLK + V+ R +Q L E RA E+ + K A++++
Sbjct: 1650 LKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIET 1709
Query: 916 RRKLEK---------QRKVEVYADADEILQEEIKE 941
+++ +K ++ AD + LQ E++E
Sbjct: 1710 SERVQLLHSQNTSLINQKKKMDADLSQ-LQTEVEE 1743
Score = 68.6 bits (166), Expect = 3e-11
Identities = 94/424 (22%), Positives = 193/424 (45%), Gaps = 70/424 (16%)
Query: 578 KKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVASALSRADRE 637
+++E+ +E+F + + +R +E E + L+E+ L L+ A+
Sbjct: 845 REKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEER 904
Query: 638 -----------KAKVEETKRK---ESELLKGLRAELKKAQESQKEMKLLLD-MYKSAPKE 682
+AKV+E + E E+ L A+ +K ++ E+K +D + + K
Sbjct: 905 CDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKV 964
Query: 683 QRDKVQLMAAERKAK------AEVDELRSRI----RELEERDRRESKKI-ADEDALRRIR 731
+++K A E K K A +DE+ +++ + L+E ++ + A+ED + +
Sbjct: 965 EKEK---HATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLT 1021
Query: 732 QA----EEQIEHLQRKLGATKQ-------EEEALLSEMDVTGQAFEDMQEQNGRLLQQLR 780
+A E+Q++ L+ L K+ + L ++ +T ++ D++ +L ++L+
Sbjct: 1022 KAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLK 1081
Query: 781 EKD----DANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKER 836
+KD N ++ E+ +Q+ K L+E + + E L+ +++A+ K+E+
Sbjct: 1082 KKDFELNALNARIEDEQALGSQLQKKLKELQARIEE----LEEELEAERTARAKVEKLRS 1137
Query: 837 ALQGSLGGVEKELT----LRSQALELNKRKAVEAAQLAEDL-KVQLEHVQTRLREIQPCL 891
L L + + L S +E+NK++ E ++ DL + L+H T
Sbjct: 1138 DLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEAT--------- 1188
Query: 892 AESRAAREKESFNLKRAQEDISRLRR---KLEKQRKVEVYADADEIL--QEEIKEYKARL 946
+ A R+K + ++ E I L+R KLEK+ K E + D++ E+I + KA L
Sbjct: 1189 --AAALRKKHADSVAELGEQIDNLQRVKQKLEKE-KSEFKLELDDVTSNMEQIIKAKANL 1245
Query: 947 TCPC 950
C
Sbjct: 1246 EKMC 1249
Score = 47.8 bits (112), Expect = 5e-05
Identities = 69/304 (22%), Positives = 133/304 (43%), Gaps = 43/304 (14%)
Query: 659 LKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSR-IRELEERDRRE 717
L K+ E +KEM + + + +L A K++A EL + + L+E++ +
Sbjct: 839 LLKSAEREKEMASMKEEF----------TRLKEALEKSEARRKELEEKMVSLLQEKNDLQ 888
Query: 718 SKKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQ 777
+ A++D L AEE+ + L + K + EA + EM+ + ED +E N L
Sbjct: 889 LQVQAEQDNLA---DAEERCDQLIKN----KIQLEAKVKEMN---ERLEDEEEMNAELTA 938
Query: 778 QLREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERA 837
+ R+ +D +L + + +EK +V L ++ + KL ++++A
Sbjct: 939 KKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKA 998
Query: 838 LQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAA 897
LQ + +L + + V+ Q +DL+ LE + +++ RA
Sbjct: 999 LQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLE------RAK 1052
Query: 898 REKESFNLKRAQEDI-------SRLRRKLEKQ--------RKVEVYADADEILQEEIKEY 942
R+ E +LK QE I +L +L+K+ ++E LQ+++KE
Sbjct: 1053 RKLEG-DLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKEL 1111
Query: 943 KARL 946
+AR+
Sbjct: 1112 QARI 1115
Score = 36.6 bits (83), Expect = 0.12
Identities = 40/184 (21%), Positives = 80/184 (43%), Gaps = 17/184 (9%)
Query: 201 RLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRISLEYSE 260
+LQ VEE Q + +E ++ A + E ++ QD + L+ + +
Sbjct: 1736 QLQTEVEEAVQECRN---AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKD 1792
Query: 261 LQDKVTSAETKVLE--------METTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYY 312
LQ ++ AE L+ +E V +L+ ++E +KR + K + ++ ++ Y
Sbjct: 1793 LQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTY 1852
Query: 313 VSGSSSG--FQGGQITLSMQ-KFEMLNAELEENQELANSRMAELEKLQAELQGAVRTNER 369
+ + + +Q K + + EE +E AN+ +++ K+Q EL A ER
Sbjct: 1853 QTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEA---EER 1909
Query: 370 LKVA 373
+A
Sbjct: 1910 ADIA 1913
Score = 36.2 bits (82), Expect = 0.16
Identities = 59/322 (18%), Positives = 128/322 (39%), Gaps = 36/322 (11%)
Query: 41 ISSTEEMDLKVLQFKNKKLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQ 100
+++ + +K LQ K +L+ D+L+E I +E+R A L A
Sbjct: 1635 MAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAEL---EELRAV 1691
Query: 101 LDETVEALLRCHESQGELSSAPEAPGTQEGPTCDGTPLPEPGTSELR---DPLLMQLRPP 157
+++T + + E S + +Q + + S+L+ + + + R
Sbjct: 1692 VEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNA 1751
Query: 158 LSEPALAFVVALGASSSEEVELELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYSRG 217
+ A A + + E + +E K + + ++ LQ R++E +++ +G
Sbjct: 1752 EEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKD---LQHRLDE-AEQIALKG 1807
Query: 218 DSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEMET 277
+ L + +A REL E Q + + + EL + +L ++
Sbjct: 1808 GKKQLQKL-EARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQD 1866
Query: 278 TVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNA 337
V+ LQ ++ +++ + EA EQ N+ ++ KF +
Sbjct: 1867 LVDKLQLKVKAYKRQAE-------EAEEQANT------------------NLSKFRKVQH 1901
Query: 338 ELEENQELANSRMAELEKLQAE 359
EL+E +E A+ +++ KL+A+
Sbjct: 1902 ELDEAEERADIAESQVNKLRAK 1923
>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapiens]
Length = 1478
Score = 101 bits (252), Expect = 3e-21
Identities = 213/1054 (20%), Positives = 417/1054 (39%), Gaps = 123/1054 (11%)
Query: 23 SREEKTTTTLIEPIRLGGISSTEEMDLKV--LQFKNKKLAERLEQRQACEDELRERIEKL 80
++E + L P+ + +EM L++ L+ + K+L ER++Q ELR + +
Sbjct: 211 TQEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQ 270
Query: 81 EKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTC-DGTPLP 139
++ T+ R A+ + + L+ + Q E++ A + +E TC G L
Sbjct: 271 GEQLQTERER----GRTAAEDNVRLTCLVAELQKQWEVTQATQNT-VKELQTCLQGLELG 325
Query: 140 EPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVEL-ELQGRMEFSKAAVSRVVEA 198
E L +L L A + + L G + ++ +
Sbjct: 326 AAEKEEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDT 385
Query: 199 SDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGR-ENRRLQDLATQLQEKH------ 251
R + + Q + G+ E + E+ R ++ +L+ L +LQ K
Sbjct: 386 KGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASL 445
Query: 252 HRISLEYSELQDKVTSAETKVLEMETTVEDL-----QWDIEKLR-KREQKLNKHLAEALE 305
R+ E + LQ++++ + ++ +++L W+ E +RE+K + E LE
Sbjct: 446 ERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLE 505
Query: 306 QLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQA----ELQ 361
Q Q Q++ + E +L ++++ + ++ LE+L EL
Sbjct: 506 QEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELP 565
Query: 362 GAVRTNERLKVALRSLPEEVVRETGEYRMLQ--------AQFSLLYNESLQVKTQLDEAR 413
A NE L SL E + E R LQ Q E Q +L++
Sbjct: 566 VAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKEL 625
Query: 414 GLLLATKNSHLRHIEHMESDELGLQKK---LRTEVIQLEDTLAQVRKEYEMLRIEFEQNL 470
++ ++ +++D LQ++ ++ + LE A +R + +
Sbjct: 626 QNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVR 685
Query: 471 AANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTP 530
A E E ++ S + QL+ + ++ ++ E+ L +Q
Sbjct: 686 KAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQC-------- 737
Query: 531 NLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEE---LVPSEE 587
+ + K + G GP T + +E+A + V + E L
Sbjct: 738 ---QQQTQLIEVLTAEKGQQGVGP-PTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVV 793
Query: 588 DFQGITPGAQGPSSRGREPEARPKRELRE---------REGPSLGPPPVASALSRADREK 638
D Q A + + + + LRE + +L V L ++RE
Sbjct: 794 DLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREG 853
Query: 639 A----KVEETKRKESELLKGLRAELKKAQESQKEMKL-LLDMYKSAPKEQRDKVQL---M 690
A + +E +++E E L+ L+ EL +A+ S +E +L ++ + + D +L +
Sbjct: 854 ALQEERADEAQQREEE-LRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQV 912
Query: 691 AAERKAKAEVDE-LRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGATKQ 749
A K V+E L ++EL+ D +E+ E R++ +++ E LQ KL A K
Sbjct: 913 CALTVEKERVEEALACAVQELQ--DAKEAASREREGLERQVAGLQQEKESLQEKLKAAKA 970
Query: 750 EEEALLSEMDVTGQAFEDMQEQNGRLLQQL--REKDDANFKLMSERIKANQIHKLLREEK 807
+L QA EQ + LQ+ +E + F+L +E + +
Sbjct: 971 AAGSLPGLQAQLAQA-----EQRAQSLQEAAHQELNTLKFQLSAEIMD-------YQSRL 1018
Query: 808 DELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRS------QALELNKR 861
GE+ L+ Q++ Q +Q EE L+ + + ++L+ S QA L K
Sbjct: 1019 KNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKD 1078
Query: 862 KAVEAAQLAEDL---KVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRK 918
K E A L EDL + +LE T+++E L + RE+ + +D++R ++
Sbjct: 1079 K--EGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKY 1136
Query: 919 LEKQRKVEVYADADEILQE-EIKEYKARLTCP-----------CCNTRKKDAVLTK---- 962
LE +R +E+ D D + Q+ + E++ +L+ C + +++ + + +
Sbjct: 1137 LE-ERLIELLRDKDALWQKSDALEFQQKLSAEERWLGDTEANHCLDCKREFSWMVRRHHC 1195
Query: 963 --CFHVFCFEC----VRGRYEARQRKCPKCNAAF 990
C +FC+ C V ++ ++ +C C A F
Sbjct: 1196 RICGRIFCYYCCNNYVLSKHGGKKERC--CRACF 1227
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 101 bits (251), Expect = 4e-21
Identities = 214/1042 (20%), Positives = 429/1042 (41%), Gaps = 145/1042 (13%)
Query: 21 KLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNKKLAERLE----QRQACEDELRER 76
+L+ E T+I+ ++ + D+ VL+ + ++ ++ +R+ ++L++
Sbjct: 195 RLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDE 254
Query: 77 IEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTC--- 133
+KL+ + A+ +AT+ + A+ + V ++ E Q SS E TQ+ T
Sbjct: 255 CKKLQSQYASSEATISQLRSELAKGPQEVAVYVQ--ELQKLKSSVNEL--TQKNQTLTEN 310
Query: 134 ------DGTPLPEPGTSELRDPLLMQL---RPPLSEPALAFVVALGASSSEEVELELQGR 184
D T L E E +Q + L L ++ +S + +EL +
Sbjct: 311 LLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEK 370
Query: 185 MEFSKAAVSRVVEASDRLQRRVEELCQRVYSRGDSEP-----LSEAAQAHT------REL 233
E ++ + E + Q E Q R + E SE Q H+ R+L
Sbjct: 371 GEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQL 430
Query: 234 GRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKRE 293
G + RL++ EK + ++LQ K++ E ++ E T +LQ ++K +++
Sbjct: 431 GEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQH 490
Query: 294 QKLNKHLAEALEQLNSGYYVSGSSSGFQG-GQITLSMQKFEMLNAELEENQELANSRMAE 352
Q+ +AL+Q + + Q QI QK + L A L++++E + E
Sbjct: 491 QE-----QQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKE 545
Query: 353 LEKLQAELQGA----------VRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNES 402
E L A++Q N L+ + L E++ ++ ++ Q L+++
Sbjct: 546 REDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQEN---LHDQV 602
Query: 403 LQVKTQLDEARGLLLATK------NSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVR 456
+ K L A+ +L+ + NS L + S +L +Q K +TE++ + +
Sbjct: 603 QEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVS-QLDIQIKAKTELLLSAEAAKTAQ 661
Query: 457 KEYEMLRIEFEQNLAANEQ--AGPINREMRHLISSLQN---HNHQLKGDAQRYK------ 505
+ ++ QN ++Q I ++ + + LQ+ H QL+ + YK
Sbjct: 662 RADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSL 721
Query: 506 -RKLREVQAEIGKLRAQA----SGSAHSTPNLGHPEDSGVSAPAPGKE-----EGGPGPV 555
+K E++ +I KL A + + + +L E E V
Sbjct: 722 EQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIV 781
Query: 556 STP--DNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRE 613
S+ D +K+ + T ++E+ + ++DF+ + +Q + E R +
Sbjct: 782 SSTRLDLQKKSEALESIKQKLTKQEEEKQI-LKQDFETL---SQETKIQHEELNNRIQTT 837
Query: 614 LREREGPSLGPPPVASALSRADREKAKVEETKRK-----ESELLKG-------------- 654
+ E + + + + LS + +KV ++ + E E KG
Sbjct: 838 VTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKEL 897
Query: 655 ---LRAELKKAQESQKEMKLLLDMYKSAPKE--------QRDKVQLMAAERKAKAEVDEL 703
L+ +++ + QKE+K L+ K A + Q +Q ++ + E +L
Sbjct: 898 KHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQL 957
Query: 704 RSRIRELEERDRRESKKI-ADEDALR-RIRQAEEQIEHLQRKLGATKQEEEALLSEMDVT 761
+ I EL++ ++ K+I A + L+ + Q E LQ++L QE A ++ V
Sbjct: 958 QGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVL 1017
Query: 762 GQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQV 821
+E QE +L ++ SE + Q K + E+ E ++ ++Q+
Sbjct: 1018 QNNYEKSQETFKQLQSDFYGRE-------SELLATRQDLKSVEEKLSLAQEDLISNRNQI 1070
Query: 822 DAQLLTVQKLEEKERALQGSLGGVEKELTLRSQAL-ELNKRKAVEAAQLA---------E 871
Q +Q+L+ + L+ E++L R +AL ++ K K+++ +L E
Sbjct: 1071 GNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIE 1130
Query: 872 DLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQRK------- 924
++K + E T+L E L + KE NLK A++ + +++KLE Q K
Sbjct: 1131 EIKCRQEKEITKLNEE---LKSHKLESIKEITNLKDAKQLL--IQQKLELQGKADSLKAA 1185
Query: 925 VEVYADADEILQEEIKEYKARL 946
VE +IL++++K+ + L
Sbjct: 1186 VEQEKRNQQILKDQVKKEEEEL 1207
Score = 90.1 bits (222), Expect = 9e-18
Identities = 156/791 (19%), Positives = 326/791 (41%), Gaps = 95/791 (12%)
Query: 186 EFSKAAVSRVVEASDRLQRRVEELCQRVYSRGDSEPLS----EAAQAHTR------ELGR 235
E ++ V+R+ E ++ +++L + R E ++ E Q T E R
Sbjct: 187 EAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERER 246
Query: 236 ENRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQK 295
E+ +L+D +LQ ++ S+L+ ++ +V ++ L+ + +L ++ Q
Sbjct: 247 ESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQT 306
Query: 296 LNKHLAE------ALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSR 349
L ++L + LE+ ++ VS + Q L Q+ + + E + +
Sbjct: 307 LTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVE 366
Query: 350 MAE----LEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQV 405
++E +KL+ EL + LK + L ++ + LQ++ + L+++ L+
Sbjct: 367 LSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLET 426
Query: 406 KTQLDEARGLLLATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIE 465
+ QL EA G L + + E LQ KL QL++ +
Sbjct: 427 ERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTN----------- 475
Query: 466 FEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGS 525
+ E++H + + + + + Q KLRE Q ++ ++ Q
Sbjct: 476 --------------STELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDK 521
Query: 526 AHSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPS 585
NL + KE D ++ G T ++++
Sbjct: 522 DQKIQNL-------EALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQ 574
Query: 586 EEDFQGITPGAQGPSSRGREPEARPKRELREREGP-SLGPPPVASALSRADREKAKVEET 644
E+ Q +T + S ++ + +++E++ V S + + +++ E+
Sbjct: 575 EQVTQ-LTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNES 633
Query: 645 KRKESELLKGLRA--ELKKAQESQKEMKL--LLDMYKSAPKEQRDKVQLMAAERKAKAEV 700
K K S+L ++A EL + E+ K + L + +A +DK Q + K ++
Sbjct: 634 KEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQEL---NKITTQL 690
Query: 701 DELRSRIRELEER-DRRESKKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMD 759
D++ +++++ +E + ES ++ + Q E++E +KL A E +A
Sbjct: 691 DQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKE--- 747
Query: 760 VTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKS 819
QA +D+Q+Q +QL ++A ++ K L EK+ + L L+
Sbjct: 748 ---QALQDLQQQ-----RQLN---------TDLELRATELSKQLEMEKEIVSSTRLDLQK 790
Query: 820 QVDAQLLTVQKL---EEKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQL------A 870
+ +A QKL EE+++ L+ + +E ++ + ELN R +L
Sbjct: 791 KSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHE--ELNNRIQTTVTELQKVKMEK 848
Query: 871 EDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYAD 930
E L +L V+ +L ++ L S++ EKE+ K A D+ + ++L+ Q +V++
Sbjct: 849 EALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENT 908
Query: 931 ADEILQEEIKE 941
E Q+E+K+
Sbjct: 909 LKE--QKELKK 917
Score = 82.8 bits (203), Expect = 1e-15
Identities = 138/720 (19%), Positives = 285/720 (39%), Gaps = 94/720 (13%)
Query: 247 LQEKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQW-DIEKLRKREQKLNKHLAEALE 305
LQ R+ + S+L T T + E++ E K +L KH +
Sbjct: 6 LQRTPGRVGSQGSDLDSSATPINTVDVNNESSSEGFICPQCMKSLGSADELFKHYEAVHD 65
Query: 306 QLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVR 365
N + S+ + +TL Q+ + L A L+E + + ELEK Q Q +
Sbjct: 66 AGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAK 125
Query: 366 TNERLKVALRSLPEEVVRE-TGEYRMLQAQFSLLYNESLQVKTQLD--EARGLLLATKNS 422
P+ +V + + E + L+ Q E+ +K D E + LAT+ +
Sbjct: 126 ------------PDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIA 173
Query: 423 HL--RHIEHMESDELGLQKKLR-TEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPI 479
+ ++ E E QK R TE + E T+ Q K + R E ++ +
Sbjct: 174 DIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQV 233
Query: 480 NREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSG 539
M ++ + + +LK + ++ + + +A I +LR++
Sbjct: 234 QTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSEL----------------- 276
Query: 540 VSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGP 599
A G +E V + +K + V T E L+ E+D+ +
Sbjct: 277 ----AKGPQEVA---VYVQELQKLKSSV-NELTQKNQTLTENLLKKEQDYTKL------- 321
Query: 600 SSRGREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAEL 659
+ E K L + S LS ++ ++ ++ E + L+ EL
Sbjct: 322 EEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEEL 381
Query: 660 KKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRE---------- 709
+ + + +K +K +++ +K Q + ++E+++L S++ E
Sbjct: 382 SEVETKYQHLKA---EFKQLQQQREEKEQ---HGLQLQSEINQLHSKLLETERQLGEAHG 435
Query: 710 -LEERDRRESKKIADE-----DALRRIRQAEEQIE-------HLQRKLGATKQEEEALLS 756
L+E+ + S+K+ D+ D ++ + EEQ++ LQ +L TKQ+ + +
Sbjct: 436 RLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQA 495
Query: 757 EMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLG 816
T + Q ++L+Q+ +KD L + K+ + LL +E+++L ++
Sbjct: 496 LQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKI-- 553
Query: 817 LKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQ 876
+ + + +L+EK LQ + +Q E K ++ Q E+L Q
Sbjct: 554 --QAGEGETAVLNQLQEKNHTLQEQV----------TQLTEKLKNQSESHKQAQENLHDQ 601
Query: 877 LEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQ 936
++ + LR Q + + + + L ++E +S+L +++ + ++ + A+A + Q
Sbjct: 602 VQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQ 661
Score = 82.0 bits (201), Expect = 3e-15
Identities = 153/801 (19%), Positives = 326/801 (40%), Gaps = 72/801 (8%)
Query: 202 LQRRVEELCQRVYSRGDSEPLSEAAQAHT---RELGRENRRLQDLATQLQEKHHRISLEY 258
LQ+ E + R D +A + T +L +N LQ+ TQL EK S +
Sbjct: 532 LQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESH 591
Query: 259 SELQDKV-----------TSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQL 307
+ Q+ + +A+ +VL +ET+V +L + + +++ +L+ + E L
Sbjct: 592 KQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELL 651
Query: 308 NSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVRTN 367
S + + Q + L++ Q+ N +L+++ A+LQ
Sbjct: 652 LS-------AEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHC 704
Query: 368 ERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHLRHI 427
+L+ L+ E+ + + L+ Q L +SL+VK ++A L + L
Sbjct: 705 SQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQA--LQDLQQQRQLNTD 762
Query: 428 EHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLI 487
+ + EL Q ++ E++ T ++K+ E L ++ E+ + ++ L
Sbjct: 763 LELRATELSKQLEMEKEIVS--STRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLS 820
Query: 488 SSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPAPGK 547
+ + +L Q +L++V+ E L + S + + S
Sbjct: 821 QETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKEN 880
Query: 548 EEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGREPE 607
++G + KE+ T +++EL S E + + + + +E
Sbjct: 881 QKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQL 940
Query: 608 ARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAELKK------ 661
+ + L++ E + L ++ +K K E + E ++ + EL+
Sbjct: 941 IQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQL 1000
Query: 662 ---AQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRES 718
AQE E + + + + K Q QL + ++E+ R ++ +EE+
Sbjct: 1001 TQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEK----- 1055
Query: 719 KKIADEDALRRIRQAEEQ---IEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRL 775
+A ED + Q Q I+ L+ +Q+ ++ +A +D+Q++
Sbjct: 1056 LSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKE---- 1111
Query: 776 LQQLREKDDANFKLMSERIKANQIHKL-LREEKD--ELGEQVLGLKSQ--------VDA- 823
+ L+EK+ L++E+ K +I ++ R+EK+ +L E++ K + DA
Sbjct: 1112 -KSLKEKE-----LVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAK 1165
Query: 824 QLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTR 883
QLL QKLE + +A SL ++ Q L+ +K E +L ++ + + +
Sbjct: 1166 QLLIQQKLELQGKA--DSLKAAVEQEKRNQQILKDQVKK--EEEELKKEFIEKEAKLHSE 1221
Query: 884 LREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLE-KQRKVEVYADADEILQEEIKEY 942
++E + + + K + + E++ ++++ + QR+V + L+ EI
Sbjct: 1222 IKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVL 1281
Query: 943 KARLTCPCCNTRKKDAVLTKC 963
+A + N ++ A+L +C
Sbjct: 1282 EATVQ---NNQDERRALLERC 1299
Score = 45.1 bits (105), Expect = 3e-04
Identities = 66/273 (24%), Positives = 110/273 (40%), Gaps = 54/273 (19%)
Query: 717 ESKKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGR-- 774
ES D + +RQ +++ LQ L K E L E++ ++ +Q+Q +
Sbjct: 75 ESNLALKRDDVTLLRQ---EVQDLQASLKEEKWYSEELKKELE----KYQGLQQQEAKPD 127
Query: 775 ------------LLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVD 822
L QQL E NF + Q+ L ++ +L ++ +KS+ D
Sbjct: 128 GLVTDSSAELQSLEQQLEEAQTENFNI-------KQMKDLFEQKAAQLATEIADIKSKYD 180
Query: 823 AQLLTVQKLEEKERALQGSLGGVEKELT-LRSQALELNKRKAVEAAQLAEDLKVQLEHVQ 881
+ + E+K L L KE T ++ EL +R +E + LK +L VQ
Sbjct: 181 EERSLREAAEQKVTRLTEEL---NKEATVIQDLKTELLQRPGIEDVAV---LKKELVQVQ 234
Query: 882 TRLREIQPCLAESRAAREKESFNLK-----------RAQEDISRLRRKLEK-QRKVEVYA 929
T + + RE+ES LK ++ IS+LR +L K ++V VY
Sbjct: 235 TLMDNM-------TLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYV 287
Query: 930 DADEILQEEIKEYKARLTCPCCNTRKKDAVLTK 962
+ L+ + E + N KK+ TK
Sbjct: 288 QELQKLKSSVNELTQKNQTLTENLLKKEQDYTK 320
Score = 37.7 bits (86), Expect = 0.054
Identities = 59/290 (20%), Positives = 119/290 (41%), Gaps = 33/290 (11%)
Query: 189 KAAVSRVVEASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTR----ELGRENRRLQDLA 244
K A + + + S + +++++E C+ + + L E + + E+ R +
Sbjct: 1081 KTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEI 1140
Query: 245 TQLQE--KHHRISL--EYSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHL 300
T+L E K H++ E + L+D + LE++ + L+ +E+ ++ +Q L +
Sbjct: 1141 TKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQV 1200
Query: 301 AEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAEL 360
+ E+L + + + + + M+K E A+L N + ++K
Sbjct: 1201 KKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSS 1260
Query: 361 QGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATK 420
Q V E+ LR GE +L+A V+ DE R LL
Sbjct: 1261 QRRVSELEKQTDDLR----------GEIAVLEA----------TVQNNQDERRALLERCL 1300
Query: 421 NSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNL 470
IE +++ L LQ+KL ++ ++ +E + L+I+ Q L
Sbjct: 1301 KGE-GEIEKLQTKVLELQRKLDNTTAAVQ----ELGRENQSLQIKHTQAL 1345
Score = 31.6 bits (70), Expect = 3.9
Identities = 41/190 (21%), Positives = 82/190 (43%), Gaps = 24/190 (12%)
Query: 178 ELELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHT----REL 233
+LELQG+ + KAA VE R Q+ +++ ++ E + + A+ H+ +E+
Sbjct: 1172 KLELQGKADSLKAA----VEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEV 1227
Query: 234 GRENR-----RLQDLATQLQEKHHRISLEY-------SELQDKVTSAETKVLEMETTVED 281
G + +L T L E + E+ SEL+ + ++ +E TV++
Sbjct: 1228 GMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQN 1287
Query: 282 LQWD----IEKLRKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNA 337
Q + +E+ K E ++ K + LE + + +L ++ + LN
Sbjct: 1288 NQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNR 1347
Query: 338 ELEENQELAN 347
+ E+ E+ N
Sbjct: 1348 KWAEDNEVQN 1357
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 100 bits (249), Expect = 7e-21
Identities = 194/858 (22%), Positives = 361/858 (42%), Gaps = 136/858 (15%)
Query: 180 ELQGRME-FSKAAVSRVVEASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENR 238
+LQ E F++A R A+ + + +EE+ + SR + E E Q E +
Sbjct: 895 QLQAETELFAEAEEMRARLAAKK--QELEEILHDLESRVEEE--EERNQILQNEKKKMQA 950
Query: 239 RLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNK 298
+QDL QL E+ +LQ + +AE K+ +ME + L+ K K ++ +
Sbjct: 951 HIQDLEEQLDEEEGA----RQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMED 1006
Query: 299 HLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSR--------- 349
+AE QL + + + + Q + E L E + QEL ++
Sbjct: 1007 RIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTD 1066
Query: 350 ----MAELE-----------KLQAELQGA--------VRTNERLKVA------LRSLPEE 380
+AEL+ K + ELQGA + N LKV + L E+
Sbjct: 1067 LQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQED 1126
Query: 381 VVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHLRHIEHMESDELGLQKK 440
E + Q L E +KT+L++ A + + + + + L+++
Sbjct: 1127 FESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEE 1186
Query: 441 LRTEVIQLED-------TLAQVRKEYEMLRIEFEQNLAANEQA-GPINREMRHLISSLQN 492
+ Q++D L ++ ++ E + F+ NL N+Q N+E+ + LQ
Sbjct: 1187 TKNHEAQIQDMRQRHATALEELSEQLEQAK-RFKANLEKNKQGLETDNKELACEVKVLQ- 1244
Query: 493 HNHQLKGDAQRYKRKL----REVQAEIG---KLRAQASGSAHSTPNLGHPEDSGVSAPAP 545
Q+K +++ ++KL +E+ A++ +LR + + A N E VS
Sbjct: 1245 ---QVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQN----ELDNVSTLLE 1297
Query: 546 GKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSS-RGR 604
E+ G K+ A + T + +EE I + +S + +
Sbjct: 1298 EAEKKG------IKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQ 1351
Query: 605 EPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAELKKAQE 664
+ E R+ E++ +L +A + D + +E + + +LLK A ++ +E
Sbjct: 1352 QEEEEEARKNLEKQVLAL-QSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEE 1410
Query: 665 S--------------QKEM-KLLLDM------YKSAPKEQRDKVQLMAAERKAKAEVDEL 703
Q+E+ L +D+ + K+Q+ QL+A E+ A E
Sbjct: 1411 KALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEE 1470
Query: 704 RSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQ 763
R R E E R+ +E+K ++ AL +A+E+ E ++L A + E L+S D G+
Sbjct: 1471 RDR-AEAEARE-KETKALSLARALEEALEAKEEFERQNKQLRA---DMEDLMSSKDDVGK 1525
Query: 764 AFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDA 823
++ E++ R L+Q E+ + + + ++A + KL L + +K+Q +
Sbjct: 1526 NVHEL-EKSKRALEQQVEEMRTQLEELEDELQATEDAKL------RLEVNMQAMKAQFER 1578
Query: 824 QLLT-VQKLEEKERALQGSLGGVEKEL--TLRSQALELNKRK-----------AVEAAQL 869
L T ++ EEK+R L + +E EL + +AL + +K +EAA
Sbjct: 1579 DLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANK 1638
Query: 870 AEDLKV-QLEHVQTRLREIQPCLAESRAARE------KES-FNLKRAQEDISRLRRKLEK 921
A D + QL +Q ++++ Q L E+RA+R+ KES LK + +I +L+ +L
Sbjct: 1639 ARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELAS 1698
Query: 922 QRKVEVYA--DADEILQE 937
+ +A + DE+ E
Sbjct: 1699 SERARRHAEQERDELADE 1716
Score = 94.0 bits (232), Expect = 6e-19
Identities = 143/718 (19%), Positives = 296/718 (41%), Gaps = 92/718 (12%)
Query: 272 VLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQK 331
+L++ E+LQ E+L K ++K K E LE++ + Q+ +
Sbjct: 844 LLQVTRQEEELQAKDEELLKVKEKQTKVEGE-LEEMERKHQQLLEEKNILAEQLQAETEL 902
Query: 332 FEMLNAELEENQELANSRMAELEKLQAELQGAVRTNE-----------RLKVALRSLPEE 380
F AE EE + ++ ELE++ +L+ V E +++ ++ L E+
Sbjct: 903 F----AEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQ 958
Query: 381 VVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHLRHIEHMESDELGLQKK 440
+ E G + LQ L + + K + E LLL +NS + + D +
Sbjct: 959 LDEEEGARQKLQ-----LEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSS 1013
Query: 441 LRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGD 500
E + LA++R + E++ + E+ L E+ L+ +L G+
Sbjct: 1014 QLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTR----------QELEKAKRKLDGE 1063
Query: 501 AQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPDN 560
+ ++ E+QA+I +L+ Q L E+ A A G +E +
Sbjct: 1064 TTDLQDQIAELQAQIDELKLQ----------LAKKEEELQGALARGDDETLHKNNALKVV 1113
Query: 561 RKEMAPVP-------GTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRE 613
R+ A + + +K++ SEE T + + E R KRE
Sbjct: 1114 RELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKRE 1173
Query: 614 LREREGPSLGPPPVASALSRADRE-KAKVEETKRKESELLKGLRAELKKAQESQKEMKLL 672
E + AL + +A++++ +++ + L+ L +L++A+ + ++
Sbjct: 1174 QEVAE--------LKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKN 1225
Query: 673 LDMYKSAPKE--------QRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADE 724
++ KE Q+ K + +K A+V EL +++ E +R R E + A +
Sbjct: 1226 KQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSE-GDRLRVELAEKASK 1284
Query: 725 DALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDD 784
+ +E ++K ++ +L S++ T + ++ Q L ++R+ ++
Sbjct: 1285 -LQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEE 1343
Query: 785 ANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGG 844
L ++ + + K L ++ L Q+ K +VD L T++ LEE ++ L
Sbjct: 1344 EKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEA 1403
Query: 845 VEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEH-------VQTRLREIQPCLAESRA- 896
+ + L ++ A + ++ Q +DL V L+H ++ + ++ LAE ++
Sbjct: 1404 LSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSI 1463
Query: 897 --------------AREKE--SFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQEE 938
AREKE + +L RA E+ + + E+Q K ++ AD ++++ +
Sbjct: 1464 SARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNK-QLRADMEDLMSSK 1520
Score = 94.0 bits (232), Expect = 6e-19
Identities = 175/959 (18%), Positives = 400/959 (41%), Gaps = 101/959 (10%)
Query: 19 EKKLSREEKTTTTLIEPIR-LGGISSTEEMDLKVLQFKNKKLAERLEQRQACEDELRERI 77
E++L +EEKT L + R L G ++ + + LQ + +L +L ++ E+EL+ +
Sbjct: 1040 EERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKK---EEELQGAL 1096
Query: 78 EKLEKRQATDDATLLIVNRYWAQLDETVE-------ALLRCHESQGELSSAPEAPGTQEG 130
+ + + L +V AQ+ E E + + + + +LS EA T+
Sbjct: 1097 ARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELE 1156
Query: 131 PTCDGTPLPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELELQGRMEFSKA 190
T D T + ++ R+ + +L+ L E ++ E ++Q +
Sbjct: 1157 DTLDTTAAQQELRTK-REQEVAELKKALEE------------ETKNHEAQIQDMRQRHAT 1203
Query: 191 AVSRVVEASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEK 250
A+ + E ++ +R + + E + + +EL E + LQ + + + K
Sbjct: 1204 ALEELSEQLEQAKR----------FKANLEKNKQGLETDNKELACEVKVLQQVKAESEHK 1253
Query: 251 HHRISLEYSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSG 310
++ + EL KV+ + +E+ LQ +++ + L E E+
Sbjct: 1254 RKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVST--------LLEEAEKKGIK 1305
Query: 311 YYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVRTNERL 370
+ +S L ++L++ QEL + E + + L +R E
Sbjct: 1306 FAKDAAS-----------------LESQLQDTQEL----LQEETRQKLNLSSRIRQLEEE 1344
Query: 371 KVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHLRHIEHM 430
K +L+ EE E + L+ Q L ++ K ++D+ G + + + + + ++
Sbjct: 1345 KNSLQEQQEE---EEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDA 1401
Query: 431 ESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISSL 490
E+ L++K +LE T ++++E + L ++ + ++ L++
Sbjct: 1402 EALSQRLEEKALA-YDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEE 1460
Query: 491 QNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPAP----G 546
++ + + + R + + RE + + L A+A A ++ + A
Sbjct: 1461 KSISARYAEERDRAEAEAREKETKALSL-ARALEEALEAKEEFERQNKQLRADMEDLMSS 1519
Query: 547 KEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSR-GRE 605
K++ G +++ + T ++EL +E+ + Q ++ R+
Sbjct: 1520 KDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERD 1579
Query: 606 PEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAELKKAQES 665
+ R ++ ++ + + L +++A +K+K LK L A+++ A ++
Sbjct: 1580 LQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKA 1639
Query: 666 QKEMKLLLDMYKSAPKE-QRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADE 724
+ E+ L ++ K+ QR+ + A+ + A+ E +++ LE + +++A
Sbjct: 1640 RDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASS 1699
Query: 725 DALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVT----GQAFEDMQEQ-------NG 773
+ RR AE++ + L ++ + + ALL E Q E+++E+ N
Sbjct: 1700 ERARR--HAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLND 1757
Query: 774 RLLQQLREKDDANFKLMSERI---KANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQK 830
R + + D N +L +ER K++ + L + EL ++ L+ V + K
Sbjct: 1758 RFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKS------K 1811
Query: 831 LEEKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPC 890
+ AL+ +G +E++L ++ + + +++ +Q+E + + +
Sbjct: 1812 FKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQ 1871
Query: 891 LAESRAAREKESFNLKRAQEDISRL---RRKLEKQRKVEVYADADEILQEEIKEYKARL 946
+ ++ A ++ L+ A+E+ +R RRKL QR+++ +A+E L E+ K RL
Sbjct: 1872 MEKANARMKQLKRQLEEAEEEATRANASRRKL--QRELDDATEANEGLSREVSTLKNRL 1928
Score = 72.8 bits (177), Expect = 2e-12
Identities = 96/382 (25%), Positives = 165/382 (43%), Gaps = 79/382 (20%)
Query: 631 LSRADREKAKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLM 690
L D E KV+E + K ++G E+++ + E K +L A E + + M
Sbjct: 854 LQAKDEELLKVKEKQTK----VEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEM 909
Query: 691 AAERKAKAE-----VDELRSRIRELEERD---RRESKKIADEDALRRIRQAEEQI---EH 739
A AK + + +L SR+ E EER+ + E KK+ I+ EEQ+ E
Sbjct: 910 RARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQ-----AHIQDLEEQLDEEEG 964
Query: 740 LQRKLGATKQEEEALLSEMDVTGQAFEDM------------------------QEQNGRL 775
++KL K EA + +M+ ED +E+ +
Sbjct: 965 ARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKN 1024
Query: 776 LQQLREKDDANFKLMSERIK-----ANQIHKLLRE---EKDELGEQVLGLKSQVDAQLLT 827
L ++R K + + ER+K ++ K R+ E +L +Q+ L++Q+D L
Sbjct: 1025 LAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKL- 1083
Query: 828 VQKLEEKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAE---------------- 871
+L +KE LQG+L + E ++ AL++ + + A+L E
Sbjct: 1084 --QLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQK 1141
Query: 872 -DLKVQLEHVQTRLREIQPCLA---ESRAAREKESFNLKRAQEDISRLRRKLEKQRKVEV 927
DL +LE ++T L + A E R RE+E LK+A E+ ++ + + Q +
Sbjct: 1142 RDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETK-NHEAQIQDMRQR 1200
Query: 928 YADADEILQEEI---KEYKARL 946
+A A E L E++ K +KA L
Sbjct: 1201 HATALEELSEQLEQAKRFKANL 1222
Score = 63.2 bits (152), Expect = 1e-09
Identities = 52/246 (21%), Positives = 119/246 (48%), Gaps = 10/246 (4%)
Query: 705 SRIRELEERDRRESKKIADEDALRRIRQ----AEEQIEHLQRKLGATKQEEEALLSEMDV 760
++++ L + R+E + A ++ L ++++ E ++E ++RK +E+ L ++
Sbjct: 839 TKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQA 898
Query: 761 TGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQ 820
+ F + +E RL + +E ++ L S + + +++L+ EK ++ + L+ Q
Sbjct: 899 ETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQ 958
Query: 821 VDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHV 880
+D + QKL+ ++ + + +E+E+ L LE K ++ +L ED +
Sbjct: 959 LDEEEGARQKLQLEKVTAEAKIKKMEEEILL----LEDQNSKFIKEKKLMEDRIAECSSQ 1014
Query: 881 QTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQEEIK 940
E LA+ R +E +L+ + + R++LEK ++ D LQ++I
Sbjct: 1015 LAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTD--LQDQIA 1072
Query: 941 EYKARL 946
E +A++
Sbjct: 1073 ELQAQI 1078
Score = 43.1 bits (100), Expect = 0.001
Identities = 49/226 (21%), Positives = 92/226 (40%), Gaps = 17/226 (7%)
Query: 174 SEEVELELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYS-RGDSEPLSEAAQAHTRE 232
+E+ EL + S + S +++ RL+ R+ +L + + + + E L++ + T +
Sbjct: 1706 AEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQ 1765
Query: 233 LGRENRRL----------QDLATQLQEKHHRISLEYSELQDKVTSA-ETKVLEMETTVED 281
+ N L + QL+ ++ + + EL+ V S + + +E +
Sbjct: 1766 VDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQ 1825
Query: 282 LQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQK----FEMLNA 337
L+ +E+ K NK L E+ ++ Q M+K + L
Sbjct: 1826 LEEQLEQEAKERAAANK-LVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKR 1884
Query: 338 ELEENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVVR 383
+LEE +E A A KLQ EL A NE L + +L + R
Sbjct: 1885 QLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRR 1930
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 99.8 bits (247), Expect = 1e-20
Identities = 192/883 (21%), Positives = 346/883 (39%), Gaps = 159/883 (18%)
Query: 195 VVEASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRE--LGRENRRLQDLATQLQEKHH 252
V++A + ++V+EL Q+ +R E AQ L + R +L + +E
Sbjct: 878 VLQARAQELQKVQEL-QQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRG 936
Query: 253 RISLEYSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYY 312
R++ EL+ V+ E +V E E +Q + ++L++ Q+L HL EA E
Sbjct: 937 RLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHL-EAEEGARQKLQ 995
Query: 313 VSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVRTNERLKV 372
+ ++ + + + E N++L + ++L R+AE AE + V++ +L++
Sbjct: 996 LEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRL 1055
Query: 373 AL---------RSLPEEVVRETGE--YRMLQAQFSLLYNESLQVKTQLDEARGLLLATKN 421
R EE R+ E R L + S L + ++ + + +E R L K
Sbjct: 1056 KYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRA-QLGRKE 1114
Query: 422 SHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVR---------------------KEYE 460
L+ DE G + +L + + + LA+ + +E E
Sbjct: 1115 EELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELE 1174
Query: 461 MLRIEFEQNL----AANEQAGPINREMRHLISSLQN----HNHQLKGDAQRYKRKLRE-- 510
LR E E L A E +E+ L +L+ H ++ QR+ + L E
Sbjct: 1175 ALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELA 1234
Query: 511 -------------------VQAEIGKLRAQASGSAHSTPNLGHPEDSGV--------SAP 543
++AE+ +LRA+ S S + G +
Sbjct: 1235 EQLEQARRGKGAWEKTRLALEAEVSELRAELS-SLQTARQEGEQRRRRLELQLQEVQGRA 1293
Query: 544 APGKEEGGPGPVSTPDNRKEMAPVPG----TTTTTTSVKKE------ELVPSEEDFQGIT 593
G+ + E+ V G + T + KE +L ++E Q T
Sbjct: 1294 GDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEET 1353
Query: 594 PGAQGPSSRGR--EPEARPKRELREREGPSLGPPPVASALSRADRE----KAKVEETKRK 647
SR R E EA RE E E A+A RA RE +A++ E +R+
Sbjct: 1354 RAKLALGSRVRAMEAEAAGLREQLEEE---------AAARERAGRELQTAQAQLSEWRRR 1404
Query: 648 ESE----LLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDEL 703
+ E L G A + A+E++ + L + ++ + +R + +L A ++++
Sbjct: 1405 QEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQ 1464
Query: 704 RSRIRELEERDRRESKKIADEDA--------------------------LRRIRQAEEQI 737
R + LE++ R+ + +A+E A R + + +E
Sbjct: 1465 RQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAR 1524
Query: 738 EHLQRKLGATKQEEEALLSEMDVTG--------------QAFEDMQEQNGRLLQQLREKD 783
E L+R+ A + E EALLS D G QA D++ Q L +L +
Sbjct: 1525 EELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAE 1584
Query: 784 DANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLG 843
DA +L H+ + +DE GE+ + Q+ QL + ++ER +
Sbjct: 1585 DAKLRLEVTVQALKTQHERDLQGRDEAGEE---RRRQLAKQLRDAEVERDEERKQRTLAV 1641
Query: 844 GVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAARE---- 899
K+L LE K + A Q E+ QL +Q +++E+ + E+R +RE
Sbjct: 1642 AARKKL---EGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFS 1698
Query: 900 ---KESFNLKRAQEDISRLRRKL--EKQRKVEVYADADEILQE 937
+ LK + ++ RL+ +L + + + D DE+ E
Sbjct: 1699 QNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADE 1741
Score = 93.2 bits (230), Expect = 1e-18
Identities = 199/978 (20%), Positives = 385/978 (39%), Gaps = 97/978 (9%)
Query: 21 KLSREEKTTTTLIEPIRLGGISSTEEM-DLKVLQFKNKKLAERLEQRQACEDELRERIEK 79
KLS+E K + E++ L L+ K + +E R E++ R+ +EK
Sbjct: 1021 KLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEK 1080
Query: 80 LEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDGTPLP 139
L++R + + L ++ VE R E + +L E D
Sbjct: 1081 LKRRLDGESSELQ---------EQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGAR 1131
Query: 140 EPGTSELRDP--LLMQLRPPLSEPALAFVVALGASSSEEVELE-LQGRMEFSKAAVSRVV 196
LR+ L + + L +A A ELE L+G +E + + +
Sbjct: 1132 AQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQ 1191
Query: 197 EASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHH---- 252
E + ++ V EL + + + + EAA R+ R + L +LA QL++
Sbjct: 1192 ELRSKREQEVTELKKTLE---EETRIHEAAVQELRQ--RHGQALGELAEQLEQARRGKGA 1246
Query: 253 ----RISLE--YSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQ 306
R++LE SEL+ +++S +T E E L+ +++++ R + AEA E+
Sbjct: 1247 WEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEK 1306
Query: 307 LNSGYY----VSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQG 362
L VSG+ + + I LS ++ A+L + QEL + E + + L
Sbjct: 1307 LQRAQAELENVSGALNEAESKTIRLS-KELSSTEAQLHDAQEL----LQEETRAKLALGS 1361
Query: 363 AVRTNERLKVALRSLPEEVV----RETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLA 418
VR E LR EE R E + QAQ S + + + +E G L A
Sbjct: 1362 RVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLS-------EWRRRQEEEAGALEA 1414
Query: 419 TKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGP 478
+ + R E+ L +K T V +LE ++++E + ++ EQ
Sbjct: 1415 GEEARRRAAREAEALTQRLAEKTET-VDRLERGRRRLQQELDDATMDLEQQRQLVSTLEK 1473
Query: 479 INREMRHLISS-----LQNHNHQLKGDAQRYKRKLR----------------EVQAEIGK 517
R+ L++ L+ + + +A+ +R+ R E++ +
Sbjct: 1474 KQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRA 1533
Query: 518 LRAQASGSAHSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSV 577
LRA+ S ++G A ++ + E+
Sbjct: 1534 LRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVT 1593
Query: 578 KKEELVPSEEDFQGITPGAQGP----SSRGREPEARPKRELREREGPSLGPPPVASALSR 633
+ E D QG + + + R+ E E ++R + L
Sbjct: 1594 VQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEE 1653
Query: 634 ADREKAKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAE 693
+ A + K + + L+ ++A++K+ +E + + S +E +++ + AE
Sbjct: 1654 LKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAE 1713
Query: 694 RKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAE--EQIEHLQRKLGATKQEE 751
E R R ++DR E +ADE A + +A E+ L+ +LG ++E
Sbjct: 1714 VLRLQEELAASDRARRQAQQDRDE---MADEVANGNLSKAAILEEKRQLEGRLGQLEEEL 1770
Query: 752 EALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDELG 811
E S ++ + + Q L +L + + K S R Q+ + ++E + LG
Sbjct: 1771 EEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGR---QQLERQIQELRGRLG 1827
Query: 812 EQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAE 871
E+ G +++ +T+ LE K L E++L ++ L+ + A + +
Sbjct: 1828 EEDAGARAR---HKMTIAALESK-------LAQAEEQLEQETRERILSGKLVRRAEKRLK 1877
Query: 872 DLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRL---RRKLEKQRKVEVY 928
++ +Q+E + +++ L + ++ L+ A+E+ SR RR+L QR++E
Sbjct: 1878 EVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRL--QRELEDV 1935
Query: 929 ADADEILQEEIKEYKARL 946
++ E + E+ + RL
Sbjct: 1936 TESAESMNREVTTLRNRL 1953
Score = 89.7 bits (221), Expect = 1e-17
Identities = 148/678 (21%), Positives = 271/678 (39%), Gaps = 93/678 (13%)
Query: 324 QITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPE---E 380
Q+T + + EL++ QEL E+ +LQ + RL LR+ E E
Sbjct: 871 QVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAE 930
Query: 381 VVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHL-RHIE----HMESDEL 435
G + + L+ +E L+ + +E + T+ L +HI+ H+E++E
Sbjct: 931 AEETRGRLAARKQELELVVSE-LEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEG 989
Query: 436 GLQ-------------KKLRTEVIQLEDTLAQVRKEYEMLR---IEFEQNLAANEQ---- 475
Q KK +++ LED +++ KE ++L EF A E+
Sbjct: 990 ARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKS 1049
Query: 476 AGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLR----AQASGSAHSTPN 531
+ + I+ +++ + + Q ++ R + E +L+ Q +
Sbjct: 1050 LNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQ 1109
Query: 532 LGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQG 591
LG E+ +A A ++EGG R+ A + ++ E + ++ + Q
Sbjct: 1110 LGRKEEELQAALARAEDEGGARAQLLKSLREAQAAL---AEAQEDLESERVARTKAEKQR 1166
Query: 592 ITPGAQGPSSRGR----------EPEARPKR-----------------------ELRERE 618
G + + RG + E R KR ELR+R
Sbjct: 1167 RDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRH 1226
Query: 619 GPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAELKKAQESQKEMK-------- 670
G +LG +A L +A R K E+T+ + LRAEL Q +++E +
Sbjct: 1227 GQALG--ELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLEL 1284
Query: 671 LLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRI 730
L ++ A +R + + ++A+AE++ + + E E + R SK+++ +A ++
Sbjct: 1285 QLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEA--QL 1342
Query: 731 RQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLM 790
A+E ++ R A A+ E + G E ++E+ + RE A +L
Sbjct: 1343 HDAQELLQEETRAKLALGSRVRAM--EAEAAGLR-EQLEEEAAARERAGRELQTAQAQLS 1399
Query: 791 SERIKANQIHKLL---REEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEK 847
R + + L E + + L ++ + TV +LE R LQ L
Sbjct: 1400 EWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATM 1459
Query: 848 ELTLRSQALELNKRKAVEAAQ-LAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLK 906
+L + Q + ++K + Q LAE+ L V+ R R AE R RE + +L
Sbjct: 1460 DLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERER----AEAEGR-EREARALSLT 1514
Query: 907 RAQEDISRLRRKLEKQRK 924
RA E+ R +LE+Q +
Sbjct: 1515 RALEEEQEAREELERQNR 1532
Score = 62.4 bits (150), Expect = 2e-09
Identities = 177/860 (20%), Positives = 316/860 (36%), Gaps = 175/860 (20%)
Query: 58 KLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGE 117
+L + L + QA E +E +E + + + L +E L +Q E
Sbjct: 1133 QLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQE 1192
Query: 118 LSSAPEAPGTQEGPTCDG-TPLPEPGTSELRD---PLLMQLRPPLSEPALAFVVALGASS 173
L S E T+ T + T + E ELR L +L L + G +
Sbjct: 1193 LRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQ------ARRGKGA 1246
Query: 174 SEEVELELQGRMEFSKAAVSRVVEA---SDRLQRRVEELCQRVYSR-GDSEPLSEAAQAH 229
E+ L L+ + +A +S + A ++ +RR+E Q V R GD E A
Sbjct: 1247 WEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEK 1306
Query: 230 TRELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAE--------------TKVLEM 275
+ E + + + K R+S E S + ++ A+ ++V M
Sbjct: 1307 LQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAM 1366
Query: 276 ETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSSSG-FQGGQITL--SMQKF 332
E L+ +E+ ++ + L A QL+ +G + G+ + ++
Sbjct: 1367 EAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREA 1426
Query: 333 EMLNAELEENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEE------------ 380
E L L E E + +LQ EL A E+ + + +L ++
Sbjct: 1427 EALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEK 1486
Query: 381 --VVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLL--LATKNSHLR-HIEHMES--D 433
V+R E +A+ +L + L+E + L +N LR +E + S D
Sbjct: 1487 AAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKD 1546
Query: 434 ELGLQ---------------KKLRTEVIQLEDTL-----AQVRKEY--EMLRIEFEQNLA 471
++G LR +V +LED L A++R E + L+ + E++L
Sbjct: 1547 DVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQ 1606
Query: 472 ANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKL-----REVQAEIGKLRAQASGSA 526
++AG R R L L++ +++ D +R +R L ++++ E+ +L+AQ + +
Sbjct: 1607 GRDEAGEERR--RQLAKQLRDA--EVERDEERKQRTLAVAARKKLEGELEELKAQMASAG 1662
Query: 527 HSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSE 586
GKEE KE+ T T+ +EE+
Sbjct: 1663 Q------------------GKEEAVKQLRKMQAQMKELWREVEETRTS----REEIFSQN 1700
Query: 587 EDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKR 646
+ + G + R +E A R R+ + +A ++ + KA + E KR
Sbjct: 1701 RESEKRLKGLEAEVLRLQEELAASDRARRQAQQDR---DEMADEVANGNLSKAAILEEKR 1757
Query: 647 KESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERK--AKAE----- 699
+ L L EL +E Q +LL D Y+ + ++AER AKAE
Sbjct: 1758 QLEGRLGQLEEEL---EEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQ 1814
Query: 700 ----VDELRSRIRE--------------------------LEERDRR------------- 716
+ ELR R+ E LE+ R
Sbjct: 1815 LERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEK 1874
Query: 717 ----------ESKKIADE--DALR----RIRQAEEQIEHLQRKLGATKQEEEALLSEMDV 760
E +++AD+ D L R++Q + Q+E + + + L E++
Sbjct: 1875 RLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELED 1934
Query: 761 TGQAFEDMQEQNGRLLQQLR 780
++ E M + L +LR
Sbjct: 1935 VTESAESMNREVTTLRNRLR 1954
Score = 61.2 bits (147), Expect = 5e-09
Identities = 114/546 (20%), Positives = 208/546 (38%), Gaps = 123/546 (22%)
Query: 172 SSSEEVELELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTR 231
S+ E+ + + + KAAV R VE +R + E R S + L E +A
Sbjct: 1469 STLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSL--TRALEEEQEAR-E 1525
Query: 232 ELGRENRRLQ-DLATQLQEKH--------------------HRISLEYSELQDKVTSAET 270
EL R+NR L+ +L L K + + + +EL+D++T+AE
Sbjct: 1526 ELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAED 1585
Query: 271 KVLEMETTVE--------DLQWDIEKLRKREQKLNKHLAEA------------------- 303
L +E TV+ DLQ E +R ++L K L +A
Sbjct: 1586 AKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARK 1645
Query: 304 -----LEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEE--------------NQE 344
LE+L + +G Q+ + + L E+EE +++
Sbjct: 1646 KLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEK 1705
Query: 345 LANSRMAELEKLQAELQGAVRTNER----------------------------LKVALRS 376
AE+ +LQ EL + R + L+ L
Sbjct: 1706 RLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQ 1765
Query: 377 LPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHL---RHIEHMES- 432
L EE+ E +L ++ L + + T+L R ++ R I+ +
Sbjct: 1766 LEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGR 1825
Query: 433 ---DELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISS 489
++ G + + + + LE LAQ ++ E E + + + + + ++ ++
Sbjct: 1826 LGEEDAGARARHKMTIAALESKLAQAEEQLEQ---ETRERILSGKLVRRAEKRLKEVVLQ 1882
Query: 490 LQNHNH---QLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHP-EDSGVSAPAP 545
++ QL+ ++ ++++++ ++ + +AS + L ED SA +
Sbjct: 1883 VEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESM 1942
Query: 546 GKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSV-KKEELVPSEEDFQGITPGAQGPSSRGR 604
+E V+T NR P+ TT T V + EE V S+E+ + PG+ GPS
Sbjct: 1943 NRE------VTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQPGS-GPSP--- 1992
Query: 605 EPEARP 610
EPE P
Sbjct: 1993 EPEGSP 1998
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 99.8 bits (247), Expect = 1e-20
Identities = 192/883 (21%), Positives = 346/883 (39%), Gaps = 159/883 (18%)
Query: 195 VVEASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRE--LGRENRRLQDLATQLQEKHH 252
V++A + ++V+EL Q+ +R E AQ L + R +L + +E
Sbjct: 870 VLQARAQELQKVQEL-QQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRG 928
Query: 253 RISLEYSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYY 312
R++ EL+ V+ E +V E E +Q + ++L++ Q+L HL EA E
Sbjct: 929 RLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHL-EAEEGARQKLQ 987
Query: 313 VSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVRTNERLKV 372
+ ++ + + + E N++L + ++L R+AE AE + V++ +L++
Sbjct: 988 LEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRL 1047
Query: 373 AL---------RSLPEEVVRETGE--YRMLQAQFSLLYNESLQVKTQLDEARGLLLATKN 421
R EE R+ E R L + S L + ++ + + +E R L K
Sbjct: 1048 KYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRA-QLGRKE 1106
Query: 422 SHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVR---------------------KEYE 460
L+ DE G + +L + + + LA+ + +E E
Sbjct: 1107 EELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELE 1166
Query: 461 MLRIEFEQNL----AANEQAGPINREMRHLISSLQN----HNHQLKGDAQRYKRKLRE-- 510
LR E E L A E +E+ L +L+ H ++ QR+ + L E
Sbjct: 1167 ALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELA 1226
Query: 511 -------------------VQAEIGKLRAQASGSAHSTPNLGHPEDSGV--------SAP 543
++AE+ +LRA+ S S + G +
Sbjct: 1227 EQLEQARRGKGAWEKTRLALEAEVSELRAELS-SLQTARQEGEQRRRRLELQLQEVQGRA 1285
Query: 544 APGKEEGGPGPVSTPDNRKEMAPVPG----TTTTTTSVKKE------ELVPSEEDFQGIT 593
G+ + E+ V G + T + KE +L ++E Q T
Sbjct: 1286 GDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEET 1345
Query: 594 PGAQGPSSRGR--EPEARPKRELREREGPSLGPPPVASALSRADRE----KAKVEETKRK 647
SR R E EA RE E E A+A RA RE +A++ E +R+
Sbjct: 1346 RAKLALGSRVRAMEAEAAGLREQLEEE---------AAARERAGRELQTAQAQLSEWRRR 1396
Query: 648 ESE----LLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDEL 703
+ E L G A + A+E++ + L + ++ + +R + +L A ++++
Sbjct: 1397 QEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQ 1456
Query: 704 RSRIRELEERDRRESKKIADEDA--------------------------LRRIRQAEEQI 737
R + LE++ R+ + +A+E A R + + +E
Sbjct: 1457 RQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAR 1516
Query: 738 EHLQRKLGATKQEEEALLSEMDVTG--------------QAFEDMQEQNGRLLQQLREKD 783
E L+R+ A + E EALLS D G QA D++ Q L +L +
Sbjct: 1517 EELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAE 1576
Query: 784 DANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLG 843
DA +L H+ + +DE GE+ + Q+ QL + ++ER +
Sbjct: 1577 DAKLRLEVTVQALKTQHERDLQGRDEAGEE---RRRQLAKQLRDAEVERDEERKQRTLAV 1633
Query: 844 GVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAARE---- 899
K+L LE K + A Q E+ QL +Q +++E+ + E+R +RE
Sbjct: 1634 AARKKL---EGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFS 1690
Query: 900 ---KESFNLKRAQEDISRLRRKL--EKQRKVEVYADADEILQE 937
+ LK + ++ RL+ +L + + + D DE+ E
Sbjct: 1691 QNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADE 1733
Score = 93.2 bits (230), Expect = 1e-18
Identities = 199/978 (20%), Positives = 385/978 (39%), Gaps = 97/978 (9%)
Query: 21 KLSREEKTTTTLIEPIRLGGISSTEEM-DLKVLQFKNKKLAERLEQRQACEDELRERIEK 79
KLS+E K + E++ L L+ K + +E R E++ R+ +EK
Sbjct: 1013 KLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEK 1072
Query: 80 LEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDGTPLP 139
L++R + + L ++ VE R E + +L E D
Sbjct: 1073 LKRRLDGESSELQ---------EQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGAR 1123
Query: 140 EPGTSELRDP--LLMQLRPPLSEPALAFVVALGASSSEEVELE-LQGRMEFSKAAVSRVV 196
LR+ L + + L +A A ELE L+G +E + + +
Sbjct: 1124 AQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQ 1183
Query: 197 EASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHH---- 252
E + ++ V EL + + + + EAA R+ R + L +LA QL++
Sbjct: 1184 ELRSKREQEVTELKKTLE---EETRIHEAAVQELRQ--RHGQALGELAEQLEQARRGKGA 1238
Query: 253 ----RISLE--YSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQ 306
R++LE SEL+ +++S +T E E L+ +++++ R + AEA E+
Sbjct: 1239 WEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEK 1298
Query: 307 LNSGYY----VSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQG 362
L VSG+ + + I LS ++ A+L + QEL + E + + L
Sbjct: 1299 LQRAQAELENVSGALNEAESKTIRLS-KELSSTEAQLHDAQEL----LQEETRAKLALGS 1353
Query: 363 AVRTNERLKVALRSLPEEVV----RETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLA 418
VR E LR EE R E + QAQ S + + + +E G L A
Sbjct: 1354 RVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLS-------EWRRRQEEEAGALEA 1406
Query: 419 TKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGP 478
+ + R E+ L +K T V +LE ++++E + ++ EQ
Sbjct: 1407 GEEARRRAAREAEALTQRLAEKTET-VDRLERGRRRLQQELDDATMDLEQQRQLVSTLEK 1465
Query: 479 INREMRHLISS-----LQNHNHQLKGDAQRYKRKLR----------------EVQAEIGK 517
R+ L++ L+ + + +A+ +R+ R E++ +
Sbjct: 1466 KQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRA 1525
Query: 518 LRAQASGSAHSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSV 577
LRA+ S ++G A ++ + E+
Sbjct: 1526 LRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVT 1585
Query: 578 KKEELVPSEEDFQGITPGAQGP----SSRGREPEARPKRELREREGPSLGPPPVASALSR 633
+ E D QG + + + R+ E E ++R + L
Sbjct: 1586 VQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEE 1645
Query: 634 ADREKAKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAE 693
+ A + K + + L+ ++A++K+ +E + + S +E +++ + AE
Sbjct: 1646 LKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAE 1705
Query: 694 RKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAE--EQIEHLQRKLGATKQEE 751
E R R ++DR E +ADE A + +A E+ L+ +LG ++E
Sbjct: 1706 VLRLQEELAASDRARRQAQQDRDE---MADEVANGNLSKAAILEEKRQLEGRLGQLEEEL 1762
Query: 752 EALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDELG 811
E S ++ + + Q L +L + + K S R Q+ + ++E + LG
Sbjct: 1763 EEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGR---QQLERQIQELRGRLG 1819
Query: 812 EQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAE 871
E+ G +++ +T+ LE K L E++L ++ L+ + A + +
Sbjct: 1820 EEDAGARAR---HKMTIAALESK-------LAQAEEQLEQETRERILSGKLVRRAEKRLK 1869
Query: 872 DLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRL---RRKLEKQRKVEVY 928
++ +Q+E + +++ L + ++ L+ A+E+ SR RR+L QR++E
Sbjct: 1870 EVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRL--QRELEDV 1927
Query: 929 ADADEILQEEIKEYKARL 946
++ E + E+ + RL
Sbjct: 1928 TESAESMNREVTTLRNRL 1945
Score = 89.7 bits (221), Expect = 1e-17
Identities = 148/678 (21%), Positives = 271/678 (39%), Gaps = 93/678 (13%)
Query: 324 QITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPE---E 380
Q+T + + EL++ QEL E+ +LQ + RL LR+ E E
Sbjct: 863 QVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAE 922
Query: 381 VVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHL-RHIE----HMESDEL 435
G + + L+ +E L+ + +E + T+ L +HI+ H+E++E
Sbjct: 923 AEETRGRLAARKQELELVVSE-LEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEG 981
Query: 436 GLQ-------------KKLRTEVIQLEDTLAQVRKEYEMLR---IEFEQNLAANEQ---- 475
Q KK +++ LED +++ KE ++L EF A E+
Sbjct: 982 ARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKS 1041
Query: 476 AGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLR----AQASGSAHSTPN 531
+ + I+ +++ + + Q ++ R + E +L+ Q +
Sbjct: 1042 LNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQ 1101
Query: 532 LGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQG 591
LG E+ +A A ++EGG R+ A + ++ E + ++ + Q
Sbjct: 1102 LGRKEEELQAALARAEDEGGARAQLLKSLREAQAAL---AEAQEDLESERVARTKAEKQR 1158
Query: 592 ITPGAQGPSSRGR----------EPEARPKR-----------------------ELRERE 618
G + + RG + E R KR ELR+R
Sbjct: 1159 RDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRH 1218
Query: 619 GPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAELKKAQESQKEMK-------- 670
G +LG +A L +A R K E+T+ + LRAEL Q +++E +
Sbjct: 1219 GQALG--ELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLEL 1276
Query: 671 LLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRI 730
L ++ A +R + + ++A+AE++ + + E E + R SK+++ +A ++
Sbjct: 1277 QLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEA--QL 1334
Query: 731 RQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLM 790
A+E ++ R A A+ E + G E ++E+ + RE A +L
Sbjct: 1335 HDAQELLQEETRAKLALGSRVRAM--EAEAAGLR-EQLEEEAAARERAGRELQTAQAQLS 1391
Query: 791 SERIKANQIHKLL---REEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEK 847
R + + L E + + L ++ + TV +LE R LQ L
Sbjct: 1392 EWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATM 1451
Query: 848 ELTLRSQALELNKRKAVEAAQ-LAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLK 906
+L + Q + ++K + Q LAE+ L V+ R R AE R RE + +L
Sbjct: 1452 DLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERER----AEAEGR-EREARALSLT 1506
Query: 907 RAQEDISRLRRKLEKQRK 924
RA E+ R +LE+Q +
Sbjct: 1507 RALEEEQEAREELERQNR 1524
Score = 62.4 bits (150), Expect = 2e-09
Identities = 177/860 (20%), Positives = 316/860 (36%), Gaps = 175/860 (20%)
Query: 58 KLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGE 117
+L + L + QA E +E +E + + + L +E L +Q E
Sbjct: 1125 QLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQE 1184
Query: 118 LSSAPEAPGTQEGPTCDG-TPLPEPGTSELRD---PLLMQLRPPLSEPALAFVVALGASS 173
L S E T+ T + T + E ELR L +L L + G +
Sbjct: 1185 LRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQ------ARRGKGA 1238
Query: 174 SEEVELELQGRMEFSKAAVSRVVEA---SDRLQRRVEELCQRVYSR-GDSEPLSEAAQAH 229
E+ L L+ + +A +S + A ++ +RR+E Q V R GD E A
Sbjct: 1239 WEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEK 1298
Query: 230 TRELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAE--------------TKVLEM 275
+ E + + + K R+S E S + ++ A+ ++V M
Sbjct: 1299 LQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAM 1358
Query: 276 ETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSSSG-FQGGQITL--SMQKF 332
E L+ +E+ ++ + L A QL+ +G + G+ + ++
Sbjct: 1359 EAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREA 1418
Query: 333 EMLNAELEENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEE------------ 380
E L L E E + +LQ EL A E+ + + +L ++
Sbjct: 1419 EALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEK 1478
Query: 381 --VVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLL--LATKNSHLR-HIEHMES--D 433
V+R E +A+ +L + L+E + L +N LR +E + S D
Sbjct: 1479 AAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKD 1538
Query: 434 ELGLQ---------------KKLRTEVIQLEDTL-----AQVRKEY--EMLRIEFEQNLA 471
++G LR +V +LED L A++R E + L+ + E++L
Sbjct: 1539 DVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQ 1598
Query: 472 ANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKL-----REVQAEIGKLRAQASGSA 526
++AG R R L L++ +++ D +R +R L ++++ E+ +L+AQ + +
Sbjct: 1599 GRDEAGEERR--RQLAKQLRDA--EVERDEERKQRTLAVAARKKLEGELEELKAQMASAG 1654
Query: 527 HSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSE 586
GKEE KE+ T T+ +EE+
Sbjct: 1655 Q------------------GKEEAVKQLRKMQAQMKELWREVEETRTS----REEIFSQN 1692
Query: 587 EDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKR 646
+ + G + R +E A R R+ + +A ++ + KA + E KR
Sbjct: 1693 RESEKRLKGLEAEVLRLQEELAASDRARRQAQQDR---DEMADEVANGNLSKAAILEEKR 1749
Query: 647 KESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERK--AKAE----- 699
+ L L EL +E Q +LL D Y+ + ++AER AKAE
Sbjct: 1750 QLEGRLGQLEEEL---EEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQ 1806
Query: 700 ----VDELRSRIRE--------------------------LEERDRR------------- 716
+ ELR R+ E LE+ R
Sbjct: 1807 LERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEK 1866
Query: 717 ----------ESKKIADE--DALR----RIRQAEEQIEHLQRKLGATKQEEEALLSEMDV 760
E +++AD+ D L R++Q + Q+E + + + L E++
Sbjct: 1867 RLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELED 1926
Query: 761 TGQAFEDMQEQNGRLLQQLR 780
++ E M + L +LR
Sbjct: 1927 VTESAESMNREVTTLRNRLR 1946
Score = 61.2 bits (147), Expect = 5e-09
Identities = 114/546 (20%), Positives = 208/546 (38%), Gaps = 123/546 (22%)
Query: 172 SSSEEVELELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTR 231
S+ E+ + + + KAAV R VE +R + E R S + L E +A
Sbjct: 1461 STLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSL--TRALEEEQEAR-E 1517
Query: 232 ELGRENRRLQ-DLATQLQEKH--------------------HRISLEYSELQDKVTSAET 270
EL R+NR L+ +L L K + + + +EL+D++T+AE
Sbjct: 1518 ELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAED 1577
Query: 271 KVLEMETTVE--------DLQWDIEKLRKREQKLNKHLAEA------------------- 303
L +E TV+ DLQ E +R ++L K L +A
Sbjct: 1578 AKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARK 1637
Query: 304 -----LEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEE--------------NQE 344
LE+L + +G Q+ + + L E+EE +++
Sbjct: 1638 KLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEK 1697
Query: 345 LANSRMAELEKLQAELQGAVRTNER----------------------------LKVALRS 376
AE+ +LQ EL + R + L+ L
Sbjct: 1698 RLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQ 1757
Query: 377 LPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHL---RHIEHMES- 432
L EE+ E +L ++ L + + T+L R ++ R I+ +
Sbjct: 1758 LEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGR 1817
Query: 433 ---DELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISS 489
++ G + + + + LE LAQ ++ E E + + + + + ++ ++
Sbjct: 1818 LGEEDAGARARHKMTIAALESKLAQAEEQLEQ---ETRERILSGKLVRRAEKRLKEVVLQ 1874
Query: 490 LQNHNH---QLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHP-EDSGVSAPAP 545
++ QL+ ++ ++++++ ++ + +AS + L ED SA +
Sbjct: 1875 VEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESM 1934
Query: 546 GKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSV-KKEELVPSEEDFQGITPGAQGPSSRGR 604
+E V+T NR P+ TT T V + EE V S+E+ + PG+ GPS
Sbjct: 1935 NRE------VTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQPGS-GPSP--- 1984
Query: 605 EPEARP 610
EPE P
Sbjct: 1985 EPEGSP 1990
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 99.8 bits (247), Expect = 1e-20
Identities = 192/883 (21%), Positives = 346/883 (39%), Gaps = 159/883 (18%)
Query: 195 VVEASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRE--LGRENRRLQDLATQLQEKHH 252
V++A + ++V+EL Q+ +R E AQ L + R +L + +E
Sbjct: 911 VLQARAQELQKVQEL-QQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRG 969
Query: 253 RISLEYSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYY 312
R++ EL+ V+ E +V E E +Q + ++L++ Q+L HL EA E
Sbjct: 970 RLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHL-EAEEGARQKLQ 1028
Query: 313 VSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVRTNERLKV 372
+ ++ + + + E N++L + ++L R+AE AE + V++ +L++
Sbjct: 1029 LEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRL 1088
Query: 373 AL---------RSLPEEVVRETGE--YRMLQAQFSLLYNESLQVKTQLDEARGLLLATKN 421
R EE R+ E R L + S L + ++ + + +E R L K
Sbjct: 1089 KYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRA-QLGRKE 1147
Query: 422 SHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVR---------------------KEYE 460
L+ DE G + +L + + + LA+ + +E E
Sbjct: 1148 EELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELE 1207
Query: 461 MLRIEFEQNL----AANEQAGPINREMRHLISSLQN----HNHQLKGDAQRYKRKLRE-- 510
LR E E L A E +E+ L +L+ H ++ QR+ + L E
Sbjct: 1208 ALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELA 1267
Query: 511 -------------------VQAEIGKLRAQASGSAHSTPNLGHPEDSGV--------SAP 543
++AE+ +LRA+ S S + G +
Sbjct: 1268 EQLEQARRGKGAWEKTRLALEAEVSELRAELS-SLQTARQEGEQRRRRLELQLQEVQGRA 1326
Query: 544 APGKEEGGPGPVSTPDNRKEMAPVPG----TTTTTTSVKKE------ELVPSEEDFQGIT 593
G+ + E+ V G + T + KE +L ++E Q T
Sbjct: 1327 GDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEET 1386
Query: 594 PGAQGPSSRGR--EPEARPKRELREREGPSLGPPPVASALSRADRE----KAKVEETKRK 647
SR R E EA RE E E A+A RA RE +A++ E +R+
Sbjct: 1387 RAKLALGSRVRAMEAEAAGLREQLEEE---------AAARERAGRELQTAQAQLSEWRRR 1437
Query: 648 ESE----LLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDEL 703
+ E L G A + A+E++ + L + ++ + +R + +L A ++++
Sbjct: 1438 QEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQ 1497
Query: 704 RSRIRELEERDRRESKKIADEDA--------------------------LRRIRQAEEQI 737
R + LE++ R+ + +A+E A R + + +E
Sbjct: 1498 RQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAR 1557
Query: 738 EHLQRKLGATKQEEEALLSEMDVTG--------------QAFEDMQEQNGRLLQQLREKD 783
E L+R+ A + E EALLS D G QA D++ Q L +L +
Sbjct: 1558 EELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAE 1617
Query: 784 DANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLG 843
DA +L H+ + +DE GE+ + Q+ QL + ++ER +
Sbjct: 1618 DAKLRLEVTVQALKTQHERDLQGRDEAGEE---RRRQLAKQLRDAEVERDEERKQRTLAV 1674
Query: 844 GVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAARE---- 899
K+L LE K + A Q E+ QL +Q +++E+ + E+R +RE
Sbjct: 1675 AARKKL---EGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFS 1731
Query: 900 ---KESFNLKRAQEDISRLRRKL--EKQRKVEVYADADEILQE 937
+ LK + ++ RL+ +L + + + D DE+ E
Sbjct: 1732 QNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADE 1774
Score = 93.2 bits (230), Expect = 1e-18
Identities = 199/978 (20%), Positives = 385/978 (39%), Gaps = 97/978 (9%)
Query: 21 KLSREEKTTTTLIEPIRLGGISSTEEM-DLKVLQFKNKKLAERLEQRQACEDELRERIEK 79
KLS+E K + E++ L L+ K + +E R E++ R+ +EK
Sbjct: 1054 KLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEK 1113
Query: 80 LEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDGTPLP 139
L++R + + L ++ VE R E + +L E D
Sbjct: 1114 LKRRLDGESSELQ---------EQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGAR 1164
Query: 140 EPGTSELRDP--LLMQLRPPLSEPALAFVVALGASSSEEVELE-LQGRMEFSKAAVSRVV 196
LR+ L + + L +A A ELE L+G +E + + +
Sbjct: 1165 AQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQ 1224
Query: 197 EASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHH---- 252
E + ++ V EL + + + + EAA R+ R + L +LA QL++
Sbjct: 1225 ELRSKREQEVTELKKTLE---EETRIHEAAVQELRQ--RHGQALGELAEQLEQARRGKGA 1279
Query: 253 ----RISLE--YSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQ 306
R++LE SEL+ +++S +T E E L+ +++++ R + AEA E+
Sbjct: 1280 WEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEK 1339
Query: 307 LNSGYY----VSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQG 362
L VSG+ + + I LS ++ A+L + QEL + E + + L
Sbjct: 1340 LQRAQAELENVSGALNEAESKTIRLS-KELSSTEAQLHDAQEL----LQEETRAKLALGS 1394
Query: 363 AVRTNERLKVALRSLPEEVV----RETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLA 418
VR E LR EE R E + QAQ S + + + +E G L A
Sbjct: 1395 RVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLS-------EWRRRQEEEAGALEA 1447
Query: 419 TKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGP 478
+ + R E+ L +K T V +LE ++++E + ++ EQ
Sbjct: 1448 GEEARRRAAREAEALTQRLAEKTET-VDRLERGRRRLQQELDDATMDLEQQRQLVSTLEK 1506
Query: 479 INREMRHLISS-----LQNHNHQLKGDAQRYKRKLR----------------EVQAEIGK 517
R+ L++ L+ + + +A+ +R+ R E++ +
Sbjct: 1507 KQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRA 1566
Query: 518 LRAQASGSAHSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSV 577
LRA+ S ++G A ++ + E+
Sbjct: 1567 LRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVT 1626
Query: 578 KKEELVPSEEDFQGITPGAQGP----SSRGREPEARPKRELREREGPSLGPPPVASALSR 633
+ E D QG + + + R+ E E ++R + L
Sbjct: 1627 VQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEE 1686
Query: 634 ADREKAKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAE 693
+ A + K + + L+ ++A++K+ +E + + S +E +++ + AE
Sbjct: 1687 LKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAE 1746
Query: 694 RKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAE--EQIEHLQRKLGATKQEE 751
E R R ++DR E +ADE A + +A E+ L+ +LG ++E
Sbjct: 1747 VLRLQEELAASDRARRQAQQDRDE---MADEVANGNLSKAAILEEKRQLEGRLGQLEEEL 1803
Query: 752 EALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDELG 811
E S ++ + + Q L +L + + K S R Q+ + ++E + LG
Sbjct: 1804 EEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGR---QQLERQIQELRGRLG 1860
Query: 812 EQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAE 871
E+ G +++ +T+ LE K L E++L ++ L+ + A + +
Sbjct: 1861 EEDAGARAR---HKMTIAALESK-------LAQAEEQLEQETRERILSGKLVRRAEKRLK 1910
Query: 872 DLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRL---RRKLEKQRKVEVY 928
++ +Q+E + +++ L + ++ L+ A+E+ SR RR+L QR++E
Sbjct: 1911 EVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRL--QRELEDV 1968
Query: 929 ADADEILQEEIKEYKARL 946
++ E + E+ + RL
Sbjct: 1969 TESAESMNREVTTLRNRL 1986
Score = 89.7 bits (221), Expect = 1e-17
Identities = 148/678 (21%), Positives = 271/678 (39%), Gaps = 93/678 (13%)
Query: 324 QITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPE---E 380
Q+T + + EL++ QEL E+ +LQ + RL LR+ E E
Sbjct: 904 QVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAE 963
Query: 381 VVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHL-RHIE----HMESDEL 435
G + + L+ +E L+ + +E + T+ L +HI+ H+E++E
Sbjct: 964 AEETRGRLAARKQELELVVSE-LEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEG 1022
Query: 436 GLQ-------------KKLRTEVIQLEDTLAQVRKEYEMLR---IEFEQNLAANEQ---- 475
Q KK +++ LED +++ KE ++L EF A E+
Sbjct: 1023 ARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKS 1082
Query: 476 AGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLR----AQASGSAHSTPN 531
+ + I+ +++ + + Q ++ R + E +L+ Q +
Sbjct: 1083 LNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQ 1142
Query: 532 LGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQG 591
LG E+ +A A ++EGG R+ A + ++ E + ++ + Q
Sbjct: 1143 LGRKEEELQAALARAEDEGGARAQLLKSLREAQAAL---AEAQEDLESERVARTKAEKQR 1199
Query: 592 ITPGAQGPSSRGR----------EPEARPKR-----------------------ELRERE 618
G + + RG + E R KR ELR+R
Sbjct: 1200 RDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRH 1259
Query: 619 GPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAELKKAQESQKEMK-------- 670
G +LG +A L +A R K E+T+ + LRAEL Q +++E +
Sbjct: 1260 GQALG--ELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLEL 1317
Query: 671 LLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRI 730
L ++ A +R + + ++A+AE++ + + E E + R SK+++ +A ++
Sbjct: 1318 QLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEA--QL 1375
Query: 731 RQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLM 790
A+E ++ R A A+ E + G E ++E+ + RE A +L
Sbjct: 1376 HDAQELLQEETRAKLALGSRVRAM--EAEAAGLR-EQLEEEAAARERAGRELQTAQAQLS 1432
Query: 791 SERIKANQIHKLL---REEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEK 847
R + + L E + + L ++ + TV +LE R LQ L
Sbjct: 1433 EWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATM 1492
Query: 848 ELTLRSQALELNKRKAVEAAQ-LAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLK 906
+L + Q + ++K + Q LAE+ L V+ R R AE R RE + +L
Sbjct: 1493 DLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERER----AEAEGR-EREARALSLT 1547
Query: 907 RAQEDISRLRRKLEKQRK 924
RA E+ R +LE+Q +
Sbjct: 1548 RALEEEQEAREELERQNR 1565
Score = 62.4 bits (150), Expect = 2e-09
Identities = 177/860 (20%), Positives = 316/860 (36%), Gaps = 175/860 (20%)
Query: 58 KLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGE 117
+L + L + QA E +E +E + + + L +E L +Q E
Sbjct: 1166 QLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQE 1225
Query: 118 LSSAPEAPGTQEGPTCDG-TPLPEPGTSELRD---PLLMQLRPPLSEPALAFVVALGASS 173
L S E T+ T + T + E ELR L +L L + G +
Sbjct: 1226 LRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQ------ARRGKGA 1279
Query: 174 SEEVELELQGRMEFSKAAVSRVVEA---SDRLQRRVEELCQRVYSR-GDSEPLSEAAQAH 229
E+ L L+ + +A +S + A ++ +RR+E Q V R GD E A
Sbjct: 1280 WEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEK 1339
Query: 230 TRELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAE--------------TKVLEM 275
+ E + + + K R+S E S + ++ A+ ++V M
Sbjct: 1340 LQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAM 1399
Query: 276 ETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSSSG-FQGGQITL--SMQKF 332
E L+ +E+ ++ + L A QL+ +G + G+ + ++
Sbjct: 1400 EAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREA 1459
Query: 333 EMLNAELEENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEE------------ 380
E L L E E + +LQ EL A E+ + + +L ++
Sbjct: 1460 EALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEK 1519
Query: 381 --VVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLL--LATKNSHLR-HIEHMES--D 433
V+R E +A+ +L + L+E + L +N LR +E + S D
Sbjct: 1520 AAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKD 1579
Query: 434 ELGLQ---------------KKLRTEVIQLEDTL-----AQVRKEY--EMLRIEFEQNLA 471
++G LR +V +LED L A++R E + L+ + E++L
Sbjct: 1580 DVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQ 1639
Query: 472 ANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKL-----REVQAEIGKLRAQASGSA 526
++AG R R L L++ +++ D +R +R L ++++ E+ +L+AQ + +
Sbjct: 1640 GRDEAGEERR--RQLAKQLRDA--EVERDEERKQRTLAVAARKKLEGELEELKAQMASAG 1695
Query: 527 HSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSE 586
GKEE KE+ T T+ +EE+
Sbjct: 1696 Q------------------GKEEAVKQLRKMQAQMKELWREVEETRTS----REEIFSQN 1733
Query: 587 EDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKR 646
+ + G + R +E A R R+ + +A ++ + KA + E KR
Sbjct: 1734 RESEKRLKGLEAEVLRLQEELAASDRARRQAQQDR---DEMADEVANGNLSKAAILEEKR 1790
Query: 647 KESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERK--AKAE----- 699
+ L L EL +E Q +LL D Y+ + ++AER AKAE
Sbjct: 1791 QLEGRLGQLEEEL---EEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQ 1847
Query: 700 ----VDELRSRIRE--------------------------LEERDRR------------- 716
+ ELR R+ E LE+ R
Sbjct: 1848 LERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEK 1907
Query: 717 ----------ESKKIADE--DALR----RIRQAEEQIEHLQRKLGATKQEEEALLSEMDV 760
E +++AD+ D L R++Q + Q+E + + + L E++
Sbjct: 1908 RLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELED 1967
Query: 761 TGQAFEDMQEQNGRLLQQLR 780
++ E M + L +LR
Sbjct: 1968 VTESAESMNREVTTLRNRLR 1987
Score = 61.2 bits (147), Expect = 5e-09
Identities = 114/546 (20%), Positives = 208/546 (38%), Gaps = 123/546 (22%)
Query: 172 SSSEEVELELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTR 231
S+ E+ + + + KAAV R VE +R + E R S + L E +A
Sbjct: 1502 STLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSL--TRALEEEQEAR-E 1558
Query: 232 ELGRENRRLQ-DLATQLQEKH--------------------HRISLEYSELQDKVTSAET 270
EL R+NR L+ +L L K + + + +EL+D++T+AE
Sbjct: 1559 ELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAED 1618
Query: 271 KVLEMETTVE--------DLQWDIEKLRKREQKLNKHLAEA------------------- 303
L +E TV+ DLQ E +R ++L K L +A
Sbjct: 1619 AKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARK 1678
Query: 304 -----LEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEE--------------NQE 344
LE+L + +G Q+ + + L E+EE +++
Sbjct: 1679 KLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEK 1738
Query: 345 LANSRMAELEKLQAELQGAVRTNER----------------------------LKVALRS 376
AE+ +LQ EL + R + L+ L
Sbjct: 1739 RLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQ 1798
Query: 377 LPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHL---RHIEHMES- 432
L EE+ E +L ++ L + + T+L R ++ R I+ +
Sbjct: 1799 LEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGR 1858
Query: 433 ---DELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISS 489
++ G + + + + LE LAQ ++ E E + + + + + ++ ++
Sbjct: 1859 LGEEDAGARARHKMTIAALESKLAQAEEQLEQ---ETRERILSGKLVRRAEKRLKEVVLQ 1915
Query: 490 LQNHNH---QLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHP-EDSGVSAPAP 545
++ QL+ ++ ++++++ ++ + +AS + L ED SA +
Sbjct: 1916 VEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESM 1975
Query: 546 GKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSV-KKEELVPSEEDFQGITPGAQGPSSRGR 604
+E V+T NR P+ TT T V + EE V S+E+ + PG+ GPS
Sbjct: 1976 NRE------VTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQPGS-GPSP--- 2025
Query: 605 EPEARP 610
EPE P
Sbjct: 2026 EPEGSP 2031
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 99.0 bits (245), Expect = 2e-20
Identities = 183/826 (22%), Positives = 317/826 (38%), Gaps = 113/826 (13%)
Query: 175 EEVELELQGRMEFSKAAVSRVVEASDRLQRRVEELC----QRVYSRGDSEPLSEAAQAHT 230
+E + ++ + V+ + + +L+++VE+L Q R D E +
Sbjct: 1001 QEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDL 1060
Query: 231 RELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAET-------KVLEMETTVEDLQ 283
+ L++ QL E+ + EY +LQ KV +T K+ E++ +E+L+
Sbjct: 1061 KLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELE 1120
Query: 284 WDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQ 343
+IE R K K ++ +L + G QI
Sbjct: 1121 EEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQI------------------ 1162
Query: 344 ELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGE-YRMLQAQFSLLYNES 402
EL R AE KL+ +L+ A +E + ALR + V E GE LQ L E
Sbjct: 1163 ELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEK 1222
Query: 403 LQVKTQLDEARGLLLATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEML 462
+ K ++D+ +E + + L+K RT LED L++ R + E +
Sbjct: 1223 SEFKLEIDDLSS-----------SMESVSKSKANLEKICRT----LEDQLSEARGKNEEI 1267
Query: 463 RIEFE----QNLAANEQAGPINREMRH---LISSLQNHNHQLKGDAQRYKRKLREVQAEI 515
+ Q +AG ++R++ ++S L + KR+L E
Sbjct: 1268 QRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAK 1327
Query: 516 GKLRAQASGSAHSTPNL--GHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTT 573
L S H L + E+ A V+ + E + T
Sbjct: 1328 NALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEEL 1387
Query: 574 TTSVKK--EELVPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVASAL 631
+ KK + L SEE + + + + + R + E+ + +A+AL
Sbjct: 1388 EEAKKKLAQRLQDSEEQVEAV----NAKCASLEKTKQRLQGEVEDLMVDVERANSLAAAL 1443
Query: 632 SRADREKAKV-EETKRKESELLKGLRAELKKAQESQKEMKLLLDMY-------------- 676
+ R KV E K K E L A LK+++ E+ L + Y
Sbjct: 1444 DKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKREN 1503
Query: 677 KSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQ 736
K+ +E D + +A K E+++ R +I ELE+ D ++A E+A + E +
Sbjct: 1504 KNLEQEIADLTEQIAENGKTIHELEKSRKQI-ELEKAD----IQLALEEAEAALEHEEAK 1558
Query: 737 IEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIK- 795
I +Q +L K E + ++E D + E ++ R ++ ++ DA + +E I+
Sbjct: 1559 ILRIQLELTQVKSEIDRKIAEKD---EEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRL 1615
Query: 796 -------ANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQ-KLEEKERA---LQGSLGG 844
N+I L + E + L+S V QL Q L++ R L+ L
Sbjct: 1616 KKKMEGDLNEIEIQLSHANRQAAETLKHLRS-VQGQLKDTQLHLDDALRGQEDLKEQLAI 1674
Query: 845 VEKELTLRSQALE---------LNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESR 895
VE+ L +E RK E L + +VQL H Q L ++
Sbjct: 1675 VERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQ------NTSLIHTK 1728
Query: 896 AAREKESFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQEEIKE 941
E + L+ ED SR R E++ K + DA ++ EE+K+
Sbjct: 1729 KKLETDLMQLQSEVEDASRDARNAEEKAK-KAITDA-AMMAEELKK 1772
Score = 96.3 bits (238), Expect = 1e-19
Identities = 173/803 (21%), Positives = 331/803 (41%), Gaps = 89/803 (11%)
Query: 174 SEEVELELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTREL 233
S E E E+ E + + ++ + + E+L V + D + +A + +
Sbjct: 843 SAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDA 902
Query: 234 GRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAET-KVLEMETTVEDLQWDIE----- 287
+L QL+ K ++ E +E ++++ + T K ++E +L+ DI+
Sbjct: 903 EERCDQLIKAKFQLEAKIKEVT-ERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELT 961
Query: 288 --KLRKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQEL 345
K+ K + + E+L+ + + Q + L AE E+
Sbjct: 962 LAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAE-EDKVNS 1020
Query: 346 ANSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQV 405
N ++LE+ +L+ ++ ++L+V L ++ G+ ++ Q L N+
Sbjct: 1021 LNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKL---EGDLKLAQESILDLEND---- 1073
Query: 406 KTQLDEARGLLLATKNSHLRHIEHMESDE--LGLQ-----KKLRTEVIQLED-------T 451
K QLDE L K+ ++ DE LGLQ K+L+ + +LE+ T
Sbjct: 1074 KQQLDER----LKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERAT 1129
Query: 452 LAQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREV 511
A+ K+ E E+ E+AG + L N + + + + +R L E
Sbjct: 1130 RAKTEKQRSDYARELEELSERLEEAGGVTSTQIEL-------NKKREAEFLKLRRDLEEA 1182
Query: 512 ----QAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPV 567
+A + LR + A S LG D+ ++E + D M V
Sbjct: 1183 TLQHEAMVAALRKK---HADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESV 1239
Query: 568 PGTTTT------TTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPS 621
+ T + E E+ Q SR + R+L E+E
Sbjct: 1240 SKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKES-- 1297
Query: 622 LGPPPVASALSRADRE-KAKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAP 680
+ S LSR+ + + EE KR+ E K A Q S+ + LL + Y+
Sbjct: 1298 -----IVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYE--- 1349
Query: 681 KEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHL 740
+EQ K +L A KA +EV + R++ E + R E + A + +R++ +EEQ+E +
Sbjct: 1350 EEQEGKAELQRALSKANSEVAQWRTKY-ETDAIQRTEELEEAKKKLAQRLQDSEEQVEAV 1408
Query: 741 QRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANF-KLMSE-RIKANQ 798
K + ++ ++ L E++ D++ N L +K NF K+++E + K +
Sbjct: 1409 NAKCASLEKTKQRLQGEVE---DLMVDVERANS--LAAALDKKQRNFDKVLAEWKTKCEE 1463
Query: 799 IHKLLR---EEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQA 855
L +E L ++ LK+ + L ++ ++ + + L+ + + +++ +
Sbjct: 1464 SQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKT 1523
Query: 856 L-ELNK-RKAVEA----AQLA-EDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRA 908
+ EL K RK +E QLA E+ + LEH + ++ IQ L + ++ +++ +
Sbjct: 1524 IHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRK---IAEK 1580
Query: 909 QEDISRLRRKLEKQRKVEVYADA 931
E+I +L+R QR VE A
Sbjct: 1581 DEEIEQLKRNY--QRTVETMQSA 1601
Score = 84.7 bits (208), Expect = 4e-16
Identities = 164/809 (20%), Positives = 325/809 (40%), Gaps = 91/809 (11%)
Query: 180 ELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYSRGDSEP----LSEAAQAHTRELGR 235
EL+ +E +A ++ + R +EEL +R+ G L++ +A +L R
Sbjct: 1118 ELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRR 1177
Query: 236 --ENRRLQD--LATQLQEKHHRISLEYSELQDKVTSAETKV----LEMETTVEDLQWDIE 287
E LQ + L++KH E E D + + K+ E + ++DL +E
Sbjct: 1178 DLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSME 1237
Query: 288 KLRKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEM------LNAELEE 341
+ K + L K +QL+ G + Q L+ QK + L+ +LEE
Sbjct: 1238 SVSKSKANLEKICRTLEDQLSEA---RGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEE 1294
Query: 342 NQ----ELANSRMA---ELEKLQAELQGAVRTNERLKVALRS-------LPEEVVRETGE 387
+ +L+ S+ A + E+L+ +L+ + L AL+S L E+ E
Sbjct: 1295 KESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEG 1354
Query: 388 YRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHLRHIEHMESDELGLQKKLRTEVIQ 447
LQ S +E Q +T+ + ++ E +E + L ++L+ Q
Sbjct: 1355 KAELQRALSKANSEVAQWRTKYE----------TDAIQRTEELEEAKKKLAQRLQDSEEQ 1404
Query: 448 ----------LEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISSLQNHNHQL 497
LE T +++ E E L ++ E+ AN A ++++ R+ L
Sbjct: 1405 VEAVNAKCASLEKTKQRLQGEVEDLMVDVER---ANSLAAALDKKQRNFDKVLAE----- 1456
Query: 498 KGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPAPGKEEGGPGPVST 557
+K K E QAE+ ++ + L + + + K E
Sbjct: 1457 ------WKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEI 1510
Query: 558 PDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRELRER 617
D +++A G T ++++ + D Q A+ R + EL +
Sbjct: 1511 ADLTEQIAE-NGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQ- 1568
Query: 618 EGPSLGPPPVASALSRADREK-AKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMY 676
V S + R EK ++E+ KR ++ +++ L S+ E L
Sbjct: 1569 ---------VKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKM 1619
Query: 677 KSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQ 736
+ E ++QL A R+A + LRS +L++ ++ +DALR +EQ
Sbjct: 1620 EGDLNEI--EIQLSHANRQAAETLKHLRSVQGQLKDT------QLHLDDALRGQEDLKEQ 1671
Query: 737 IEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKA 796
+ ++R+ + E E L + ++ T +A + +++ ++++ N L+ + K
Sbjct: 1672 LAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKL 1731
Query: 797 NQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQAL 856
L+ E ++ + + + + E+ + Q + +E+ Q +
Sbjct: 1732 ETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTV 1791
Query: 857 ELNKRKAVEAAQLA-EDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRL 915
+ + + EA QLA + K Q++ ++TR+RE++ L + + L++ + + L
Sbjct: 1792 KDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKEL 1851
Query: 916 RRKLEKQRK-VEVYADADEILQEEIKEYK 943
+ E+ RK V D + LQ ++K YK
Sbjct: 1852 TYQSEEDRKNVLRLQDLVDKLQVKVKSYK 1880
Score = 81.3 bits (199), Expect = 4e-15
Identities = 153/822 (18%), Positives = 323/822 (39%), Gaps = 101/822 (12%)
Query: 171 ASSSEEVELELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHT 230
A EE+ EL + + S + + D L+ + ++ + + T
Sbjct: 927 AEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKV------EKEKHATENKVKNLT 980
Query: 231 RELGRENRRLQDLATQ---LQEKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQWDIE 287
EL + + L + LQE H + + +DKV S ++E VEDL+ +E
Sbjct: 981 EELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLE 1040
Query: 288 K-------LRKREQKLNKHLAEALEQL----NSGYYVSG--SSSGFQGGQITLSMQKFEM 334
+ L + ++KL L A E + N + F+ Q+ ++ +
Sbjct: 1041 QEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQT 1100
Query: 335 LNAELEENQELANSRMAEL-EKLQAELQGAVRTNERLKVALRSLPE--EVVRETGEYRML 391
L + ++ + +R+ EL E+++AE +T ++ R L E E + E G
Sbjct: 1101 LGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTST 1160
Query: 392 QAQFSLLYN-ESLQVKTQLDEA----RGLLLATKNSHLRHIEHMESDELGLQKKLRTEVI 446
Q + + E L+++ L+EA ++ A + H + ELG Q +
Sbjct: 1161 QIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVA-----ELGEQ------ID 1209
Query: 447 QLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKR 506
L+ ++ KE ++E + ++ E + + +L++ + +G + +R
Sbjct: 1210 NLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQR 1269
Query: 507 KLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAP 566
L E+ + +L+ +A + ++S VS + K+
Sbjct: 1270 SLSELTTQKSRLQTEAGELSRQL----EEKESIVSQLSRSKQ------------------ 1307
Query: 567 VPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPP 626
T T +K++ EE+ + A S + + ++ E+EG +
Sbjct: 1308 --AFTQQTEELKRQ----LEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRA 1361
Query: 627 VASALSRADREKAKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDK 686
++ A S + + K E + +E L+ A+ K AQ Q + + + ++ K
Sbjct: 1362 LSKANSEVAQWRTKYETDAIQRTEELE--EAKKKLAQRLQDSEEQVEAVNAKCASLEKTK 1419
Query: 687 VQLMAAERKAKAEVDELRSRIRELEERDRRESKKIAD-----EDALRRIRQAEEQIEHLQ 741
+L +V+ S L+++ R K +A+ E++ + + ++ L
Sbjct: 1420 QRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLS 1479
Query: 742 RKLGATKQEEEALLSEMDVT-------GQAFEDMQEQ---NGRLLQQLR------EKDDA 785
+L K E L +++ Q D+ EQ NG+ + +L E + A
Sbjct: 1480 TELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKA 1539
Query: 786 NFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGV 845
+ +L E +A H+ + + +L ++ +KS++D +K+ EK+ ++
Sbjct: 1540 DIQLALEEAEAALEHEEAKILRIQL--ELTQVKSEID------RKIAEKDEEIEQLKRNY 1591
Query: 846 EKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNL 905
++ + AL+ R EA +L + ++ L ++ +L AE+ L
Sbjct: 1592 QRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQL 1651
Query: 906 KRAQEDI-SRLRRKLEKQRKVEVYADADEILQEEIKEYKARL 946
K Q + LR + + + ++ + +LQ E++E +A L
Sbjct: 1652 KDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATL 1693
Score = 62.4 bits (150), Expect = 2e-09
Identities = 72/321 (22%), Positives = 142/321 (44%), Gaps = 42/321 (13%)
Query: 639 AKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKA 698
AKVE+ K +K L EL E+ K R+K L A ++A
Sbjct: 963 AKVEKEKHATENKVKNLTEELSGLDET-------------IAKLTREKKALQEAHQQALD 1009
Query: 699 EVDELRSRIRELEERDRRESKKIAD-EDALRRIRQAEEQIEHLQRKL-GATKQEEEALLS 756
++ ++ L + + +++ D E +L + ++ +E +RKL G K +E++L
Sbjct: 1010 DLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESIL- 1068
Query: 757 EMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLG 816
D++ +L ++L++KD +L S+ + +++ EL ++
Sbjct: 1069 ----------DLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEE 1118
Query: 817 LKSQVDAQLLTVQKLEEKE----RALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAED 872
L+ +++A+ T K E++ R L+ +E+ + S +ELNK++ E +L D
Sbjct: 1119 LEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRD 1178
Query: 873 L-KVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYADA 931
L + L+H + +A R L +++ R+++KLEK+ K E +
Sbjct: 1179 LEEATLQH--------EAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKE-KSEFKLEI 1229
Query: 932 DEI--LQEEIKEYKARLTCPC 950
D++ E + + KA L C
Sbjct: 1230 DDLSSSMESVSKSKANLEKIC 1250
Score = 60.1 bits (144), Expect = 1e-08
Identities = 73/320 (22%), Positives = 144/320 (45%), Gaps = 36/320 (11%)
Query: 631 LSRADREKAKV---EETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKV 687
L A+ EK EE ++ + EL K +E K+ + +K + L+ + + Q +
Sbjct: 841 LKSAETEKEMATMKEEFQKTKDELAK---SEAKRKELEEKLVTLVQEKNDLQLQVQAESE 897
Query: 688 QLMAAERKAKAEVD---ELRSRIRELEERDRRESKKIADEDALRRIRQAE-----EQIEH 739
L+ AE + + +L ++I+E+ ER E + A+ A +R + E + I+
Sbjct: 898 NLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD 957
Query: 740 LQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFK----LMSERIK 795
L+ L ++E+ A +++ + + E +L ++ + +A+ + L +E K
Sbjct: 958 LELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDK 1017
Query: 796 ANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLG-GVEKELTLRSQ 854
N ++K K +L +QV L+S ++ + LE +R L+G L E L L +
Sbjct: 1018 VNSLNKT----KSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLEND 1073
Query: 855 ALELN---KRKAVEAAQL---AED-------LKVQLEHVQTRLREIQPCLAESRAAREKE 901
+L+ K+K E QL ED + +++ +Q R+ E++ + RA R K
Sbjct: 1074 KQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKT 1133
Query: 902 SFNLKRAQEDISRLRRKLEK 921
++ L +LE+
Sbjct: 1134 EKQRSDYARELEELSERLEE 1153
Score = 37.4 bits (85), Expect = 0.071
Identities = 37/195 (18%), Positives = 78/195 (40%)
Query: 175 EEVELELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELG 234
EE+ L+ K A ++++++R+Q + ++++ E Q+ +
Sbjct: 1687 EELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDAS 1746
Query: 235 RENRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQ 294
R+ R ++ A + ++ E + QD E +E TV+DLQ +++ +
Sbjct: 1747 RDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLAL 1806
Query: 295 KLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELE 354
K K + LE + + ++K+E EL E + L+
Sbjct: 1807 KGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQ 1866
Query: 355 KLQAELQGAVRTNER 369
L +LQ V++ +R
Sbjct: 1867 DLVDKLQVKVKSYKR 1881
Score = 36.2 bits (82), Expect = 0.16
Identities = 39/184 (21%), Positives = 80/184 (43%), Gaps = 17/184 (9%)
Query: 201 RLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRISLEYSE 260
+LQ VE+ + ++E ++ A + E ++ QD + L+ + +
Sbjct: 1737 QLQSEVEDASR---DARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKD 1793
Query: 261 LQDKVTSAETKVLE--------METTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYY 312
LQ ++ AE L+ +ET + +L++++E +K+ + K L + ++ Y
Sbjct: 1794 LQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTY 1853
Query: 313 VSGSS--SGFQGGQITLSMQ-KFEMLNAELEENQELANSRMAELEKLQAELQGAVRTNER 369
S + + + +Q K + + EE E AN+ + + K Q EL+ A ER
Sbjct: 1854 QSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEA---EER 1910
Query: 370 LKVA 373
+A
Sbjct: 1911 ADIA 1914
Score = 34.7 bits (78), Expect = 0.46
Identities = 36/160 (22%), Positives = 72/160 (45%), Gaps = 16/160 (10%)
Query: 200 DRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRISLEYS 259
+R+++ +E+ + + R D +A L +++Q L T+++E + E
Sbjct: 1781 ERMKKNLEQTVKDLQHRLD--------EAEQLALKGGKKQIQKLETRIRE----LEFELE 1828
Query: 260 ELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSSSG 319
Q K T + + + E V++L + E+ RK +L + L + L+ Y +
Sbjct: 1829 GEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRL-QDLVDKLQVKVKSYKRQAEEAD 1887
Query: 320 FQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAE 359
Q + KF ELEE +E A+ +++ KL+A+
Sbjct: 1888 EQANA---HLTKFRKAQHELEEAEERADIAESQVNKLRAK 1924
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 98.2 bits (243), Expect = 3e-20
Identities = 156/759 (20%), Positives = 316/759 (41%), Gaps = 86/759 (11%)
Query: 201 RLQRRVEELCQRVYSRGDSEP-LSEAAQAHTRELGRENRR-----------LQDLATQLQ 248
R+QR + +L Q+ S EP ++E + + + L E+ R L+++ +++
Sbjct: 237 RIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIE 296
Query: 249 EKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLN 308
+ ++ ++ + ++K L + T ED + R E +++ H E+L +
Sbjct: 297 TQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHE---RTRRLAEAEMHVHHLESLLEQK 353
Query: 309 SGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQ-----GA 363
+ + K + L +E +S L L+ E+Q GA
Sbjct: 354 EKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGA 413
Query: 364 VRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSH 423
+ T ER EE +++ YR + + N+ QVK +L LLA +
Sbjct: 414 LSTEER---------EEEMKQMEVYR---SHSKFMKNKIGQVKQELSRKDTELLALQTK- 460
Query: 424 LRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREM 483
L + + SD + L+ + E A ++ E + LR+ E+ + ++M
Sbjct: 461 LETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDM 520
Query: 484 RHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGH------PED 537
+ H LK +RK+ +Q +I L+ Q +L +
Sbjct: 521 AEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADT 580
Query: 538 SGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQ 597
+ EE T + KE K+EE+ ++D + +
Sbjct: 581 TNTDTALTTLEEALAEKERTIERLKEQRD------RDEREKQEEIDNYKKDLKDL----- 629
Query: 598 GPSSRGREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEET-----KRKESELL 652
+E + + +L E+E L AS+L+ + +K +T ++K+ E L
Sbjct: 630 ------KEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECL 683
Query: 653 KGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEE 712
K + ++LKKA E+ E + +M +R+ + KA+AEVD L ++E+E
Sbjct: 684 K-MESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVEN 742
Query: 713 RDRRESKKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQN 772
+ KKIA+ + R+++ +++ +L+ K K++ +L E + +++ + +
Sbjct: 743 EKNDKDKKIAELE--RQVKDQNKKVANLKHKEQVEKKKSAQMLEE---ARRREDNLNDSS 797
Query: 773 GRLLQQLREKDDANFKL-----MSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLT 827
+L LR+KDD +L S +I A + L +EE + QV+ L+
Sbjct: 798 QQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAE-----KQVEELLMA 852
Query: 828 VQKLEEKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTRLREI 887
++K++++ +++ L ++ +L + L +A L E L+++ E + + E
Sbjct: 853 MEKVKQELESMKAKLSSTQQ--SLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISE- 909
Query: 888 QPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQRKVE 926
++ A + S + K+ QE+++ L+R EK R V+
Sbjct: 910 ----KDANIALLELSSSKKKTQEEVAALKR--EKDRLVQ 942
Score = 70.1 bits (170), Expect = 1e-11
Identities = 101/468 (21%), Positives = 199/468 (42%), Gaps = 41/468 (8%)
Query: 45 EEMDLKVLQFKNKKLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDET 104
+E + VLQ K + L E+L ++ L+ER++ L+ D L + A+ + T
Sbjct: 541 KERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERT 600
Query: 105 VEALLRCHESQGELSSAPEAPGTQEGPTCDGTPLPEPGTSELRDPLLMQLRPPLSEPALA 164
+E L+ + E E ++ +L++ + + L+ LSE +
Sbjct: 601 IER-LKEQRDRDEREKQEEIDNYKK------------DLKDLKEKVSL-LQGDLSEKEAS 646
Query: 165 FV-VALGASSSEEVELELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYSRGDSEPLS 223
+ + ASS L+ R++ + A+ + E +++ ++++ + S +S
Sbjct: 647 LLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMS 706
Query: 224 EAAQAHTRELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQ 283
+ Q L RE R +D +++ Q + R+ E++++ + K+ E+E V+D
Sbjct: 707 DRIQ----HLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQN 762
Query: 284 WDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQ 343
+ L+ +EQ K A+ LE+ SS Q+ S++K + ELEE
Sbjct: 763 KKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSS----QQLQDSLRKKDDRIEELEEAL 818
Query: 344 ELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESL 403
+ AE E + A+ + A RTN +V + E V++ E ++A+ S
Sbjct: 819 RESVQITAEREMVLAQEESA-RTNAEKQVEELLMAMEKVKQ--ELESMKAKLSSTQQSLA 875
Query: 404 QVKTQLDEARGLLLATKNSHLRHIEHMESDEL--GLQKK--------LRTEVIQLEDTLA 453
+ +T L R A + HL + M+ + L + +K L + + ++ +A
Sbjct: 876 EKETHLTNLR----AERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVA 931
Query: 454 QVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISSLQNH-NHQLKGD 500
+++E + L + +Q + N E H SS N NH+ D
Sbjct: 932 ALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPD 979
Score = 62.4 bits (150), Expect = 2e-09
Identities = 161/813 (19%), Positives = 321/813 (39%), Gaps = 169/813 (20%)
Query: 42 SSTEEMDLKVLQFKNKKLAERLEQRQACE-DELRERIEKLEKRQATDDATLLIVNRYWAQ 100
S T E + L +N + +RQA E LR+ +E++E R T TL
Sbjct: 252 SRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTL-------NA 304
Query: 101 LDETVEALLRCHESQGELSSAPEAPGTQEGPTCDGT----------PLPEPGTSELRDPL 150
DE+++ LL +S+G + A E + + E S LR+ +
Sbjct: 305 RDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEM 364
Query: 151 LMQLR---PPLSEPALAFVVALGASSSEEVE-----LELQGRMEFSKAAVSRVVEASDRL 202
+ AL V+ + S +E LE + +M S A+S
Sbjct: 365 HRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALST-------- 416
Query: 203 QRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRIS---LEYS 259
+ R EE+ Q R S+ + +EL R++ L L T+L+ ++ S
Sbjct: 417 EEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIE 476
Query: 260 ELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSSSG 319
L++ +T+ E + ++T V+ L+ +E+ K K + + E+ G+ +G
Sbjct: 477 VLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEE-------KGTQAG 529
Query: 320 ----------FQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAE---------- 359
+ ++ + +K E L +L + ++ +S ++ LQA+
Sbjct: 530 EIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTT 589
Query: 360 ----LQGAVRTNERLKVAL----RSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDE 411
L RT ERLK R EE+ + + L+ + SLL + + + L +
Sbjct: 590 LEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLD 649
Query: 412 ARGLLLATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLA 471
+ + +S L+ +++ E+ L++K + E +++E +Q++K +E A
Sbjct: 650 LKEHASSLASSGLKKDSRLKTLEIALEQK-KEECLKME---SQLKKAHEA---------A 696
Query: 472 ANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPN 531
+A P EM I L+ + RYK + + QAE+ +L N
Sbjct: 697 LEARASP---EMSDRIQHLER-------EITRYKDESSKAQAEVDRLLEILK----EVEN 742
Query: 532 LGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQG 591
+ +D ++ D K++A ++K +E V ++ Q
Sbjct: 743 EKNDKDKKIAELER----------QVKDQNKKVA----------NLKHKEQVEKKKSAQM 782
Query: 592 ITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESEL 651
+ EAR R + + + +L + D ++EE R+ ++
Sbjct: 783 LE-------------EAR-----RREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQI 824
Query: 652 LKGLRAELKKAQE------SQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRS 705
E+ AQE ++K+++ +L+ A K K E++ +++
Sbjct: 825 TA--EREMVLAQEESARTNAEKQVE-----------------ELLMAMEKVKQELESMKA 865
Query: 706 RIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAF 765
++ ++ + + + A RR + EE +E Q L A E++A ++ ++++
Sbjct: 866 KLSSTQQSLAEKETHLTNLRAERR-KHLEEVLEMKQEALLAAISEKDANIALLELSSSKK 924
Query: 766 EDMQE------QNGRLLQQLREKDDANFKLMSE 792
+ +E + RL+QQL+++ KLM++
Sbjct: 925 KTQEEVAALKREKDRLVQQLKQQTQNRMKLMAD 957
Score = 53.1 bits (126), Expect = 1e-06
Identities = 88/414 (21%), Positives = 189/414 (45%), Gaps = 60/414 (14%)
Query: 557 TPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRELRE 616
+P+ +KE A + T K++ V EE+ + + + E R +R+L +
Sbjct: 191 SPELKKERALRKDEASKITIWKEQYRVVQEENQH------MQMTIQALQDELRIQRDLNQ 244
Query: 617 ---REGPSLGPPPVASALSRADREKAKVE-ETKRKESELLKGLRAELKKAQESQKE---- 668
++ S P + L+ + ++ E E + KE LL+ E++ E+QK+
Sbjct: 245 LFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNA 304
Query: 669 ----MKLLLDMYKS------APKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRES 718
+K LL+M +S A +E ++ + +A +A+ V L S LE++++ S
Sbjct: 305 RDESIKKLLEMLQSKGLSAKATEEDHERTRRLA---EAEMHVHHLESL---LEQKEKENS 358
Query: 719 KKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQ 778
+ E+ RR A + + + L + +++ +S M+ + D++E+ +Q
Sbjct: 359 --MLREEMHRRFENAPDSAK--TKALQTVIEMKDSKISSME---RGLRDLEEE----IQM 407
Query: 779 LREKDDANFKLMSERIKANQIHKLLRE-EKDELGEQVLGLKSQVDAQLLTVQKLEEKERA 837
L+ + + E +K ++++ + K+++G QV S+ D +LL +Q K
Sbjct: 408 LKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIG-QVKQELSRKDTELLALQT---KLET 463
Query: 838 LQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTRL----REIQPCLAE 893
L ++ + + ++L +++A + L+++LE +T L ++IQ +AE
Sbjct: 464 LTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQD-MAE 522
Query: 894 SRAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQEEIKEYKARLT 947
+ + E +LK + K+RKV V E LQE++++ + +++
Sbjct: 523 EKGTQAGEIHDLKDMLD---------VKERKVNVLQKKIENLQEQLRDKEKQMS 567
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 96.7 bits (239), Expect = 1e-19
Identities = 178/988 (18%), Positives = 394/988 (39%), Gaps = 117/988 (11%)
Query: 19 EKKLSREEKTTTTL-IEPIRLGGISSTEEMDLKVLQFKNKKLAERLEQRQACEDELRERI 77
E++L EE L +E + E + +L+ +N KLA+ +++ ED + E
Sbjct: 949 EEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAK---EKKLLEDRIAEFT 1005
Query: 78 EKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDGTP 137
L + + + + N++ A + + E L R + + EL T+ D T
Sbjct: 1006 TNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEK------TRRKLEGDSTD 1059
Query: 138 LPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELELQGRMEFSKAAVSRVVE 197
L + + +L+ ++E + A EE++ L R+E A + ++
Sbjct: 1060 LSDQ---------IAELQAQIAELKMQL-----AKKEEELQAAL-ARVEEEAAQKNMALK 1104
Query: 198 ASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRISL- 256
L+ ++ EL + + S S A+ R+LG E L+ L T+L++ +
Sbjct: 1105 KIRELESQISELQEDLESERASR---NKAEKQKRDLGEE---LEALKTELEDTLDSTAAQ 1158
Query: 257 -EYSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSG 315
E +++ + K LE E + Q I+++R++ + + LAE LEQ
Sbjct: 1159 QELRSKREQEVNILKKTLEEEAKTHEAQ--IQEMRQKHSQAVEELAEQLEQTKR------ 1210
Query: 316 SSSGFQGGQITLSMQKFEMLNAE---LEENQELANSRM---AELEKLQAELQGAVRTNER 369
+ + + TL ++ E+ N L+ + + R A+L++LQ + R
Sbjct: 1211 VKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTE 1270
Query: 370 LKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHLR---H 426
L + L E+ TG ++ S L + +++QL + + LL L
Sbjct: 1271 LADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTK 1330
Query: 427 IEHMESDELGLQKKLRTEVI---QLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREM 483
++ +E ++ +++L E LE +A + + ++ + E ++ E A + R++
Sbjct: 1331 LKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKL 1390
Query: 484 RHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAP 543
+ + L + + + ++ +Q E+ L S NL +
Sbjct: 1391 QKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLL 1450
Query: 544 APGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRG 603
A K D + A T + + EE + + + + +
Sbjct: 1451 AEEKTISAKY-AEERDRAEAEAREKETKALSLARALEEAMEQKAELERLN---------- 1499
Query: 604 REPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAELKKAQ 663
K+ E E V ++ ++ K +E+ + L+ L EL+ +
Sbjct: 1500 -------KQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATE 1552
Query: 664 ESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIAD 723
+++ +++ L K A E+ + + +E K K V ++R ELE+ ++ S +A
Sbjct: 1553 DAKLRLEVNLQAMK-AQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAA 1611
Query: 724 EDALR--------RIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRL 775
L I A + + ++L + + + + E+D T + E++ Q
Sbjct: 1612 RKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKEN 1671
Query: 776 LQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQV----------LGLKSQVDAQL 825
++L+ + +L E A + + ++E+DEL +++ L K +++A++
Sbjct: 1672 EKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARI 1731
Query: 826 LTV-QKLEEKE----------RALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLK 874
+ ++LEE++ + + + +L L + N+ + + ++LK
Sbjct: 1732 AQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELK 1791
Query: 875 VQLEHVQTRLRE--------IQPCLAESRAAREKESFNLKRAQEDISRLRRKL------- 919
V+L+ ++ ++ ++ +A+ + E+ + A + + R +KL
Sbjct: 1792 VKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQV 1851
Query: 920 -EKQRKVEVYADADEILQEEIKEYKARL 946
+++R E Y D + +K+ K +L
Sbjct: 1852 DDERRNAEQYKDQADKASTRLKQLKRQL 1879
Score = 88.6 bits (218), Expect = 3e-17
Identities = 144/727 (19%), Positives = 291/727 (40%), Gaps = 138/727 (18%)
Query: 257 EYSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQ-KLNKHLAEALEQLNSGYYVSG 315
E ++++K +AE ++ EMET L EKL+ +EQ + L E+L +
Sbjct: 853 ELVKVREKQLAAENRLTEMETLQSQLM--AEKLQLQEQLQAETELCAEAEELRA------ 904
Query: 316 SSSGFQGGQITLSMQKFEM----LNAELEENQELANSRMAELEKLQAELQGAVRTNERLK 371
++T Q+ E L A +EE +E AE +K+Q +Q
Sbjct: 905 --------RLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQ---------- 946
Query: 372 VALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHLRHIEHME 431
L E++ E + LQ L + + K + E ++L +N L + +
Sbjct: 947 ----ELEEQLEEEESARQKLQ-----LEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLL 997
Query: 432 SDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISSLQ 491
D + TE + +LA+++ ++E + + E+ L E+ L+
Sbjct: 998 EDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQR----------QELE 1047
Query: 492 NHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPAPGKEEGG 551
+L+GD+ ++ E+QA+I +L+ Q L E+ +A A +EE
Sbjct: 1048 KTRRKLEGDSTDLSDQIAELQAQIAELKMQ----------LAKKEEELQAALARVEEEAA 1097
Query: 552 PGPVSTPDNRKEMAPVP-------GTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGR 604
++ R+ + + + +K++ EE T S
Sbjct: 1098 QKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAA 1157
Query: 605 EPEARPKRELREREGPSLGPPPVASALSRADREKAK-----VEETKRKESELLKGLRAEL 659
+ E R KRE + L + E+AK ++E ++K S+ ++ L +L
Sbjct: 1158 QQELRSKREQE------------VNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQL 1205
Query: 660 KKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAA--------ERKAKAEVDELRSRIRELE 711
++ + + ++ ++ E ++V+++ +K +A++ EL+ + E E
Sbjct: 1206 EQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGE 1265
Query: 712 ERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQ 771
R ++AD ++ + + +++++ L + + L + +D QE
Sbjct: 1266 ----RVRTELAD-----KVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQEL 1316
Query: 772 NGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDE----------LGEQVLGLKSQV 821
L ++ R+K + KL + N + L EE++ L QV +K ++
Sbjct: 1317 ---LQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKM 1373
Query: 822 DAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEH-- 879
+ + ++ EE +R LQ L G+ + + A + ++ Q +DL V L+H
Sbjct: 1374 EDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQR 1433
Query: 880 -----VQTRLREIQPCLAESRA---------------AREKE--SFNLKRAQEDISRLRR 917
++ + ++ LAE + AREKE + +L RA E+ +
Sbjct: 1434 QSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKA 1493
Query: 918 KLEKQRK 924
+LE+ K
Sbjct: 1494 ELERLNK 1500
Score = 77.0 bits (188), Expect = 8e-14
Identities = 160/819 (19%), Positives = 317/819 (38%), Gaps = 122/819 (14%)
Query: 201 RLQRRVEELCQRVYSRGDSEPLS---EAAQAHTRELGRENRRLQDLAT----------QL 247
RL +V+ L Q SR + E ++ E + ++L ENR L ++ T QL
Sbjct: 829 RLFTKVKPLLQ--VSRQEEEMMAKEEELVKVREKQLAAENR-LTEMETLQSQLMAEKLQL 885
Query: 248 QEK---HHRISLEYSELQDKVTSAETKVLEMETTVEDLQWDIEK-------LRKREQKLN 297
QE+ + E EL+ ++T+ K E+E DL+ +E+ L+ ++K+
Sbjct: 886 QEQLQAETELCAEAEELRARLTA---KKQELEEICHDLEARVEEEEERCQHLQAEKKKMQ 942
Query: 298 KHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQK---------FEMLNAELEENQELANS 348
+++ E EQL + Q ++T + E N +L + ++L
Sbjct: 943 QNIQELEEQLEE---EESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLED 999
Query: 349 RMAE----LEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQ 404
R+AE L + + + + + + + + L E + RE + + L+ L +S
Sbjct: 1000 RIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTD 1059
Query: 405 VKTQLDEARGLLLATKNSHLRHIEHMES-----DELGLQKKLRTEVI-QLEDTLAQVRKE 458
+ Q+ E + + K + E +++ +E QK + + I +LE +++++++
Sbjct: 1060 LSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQED 1119
Query: 459 YEMLRIEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKL 518
E R + A +Q + E+ L + L++ AQ+ R RE + I K
Sbjct: 1120 LESERASRNK---AEKQKRDLGEELEALKTELEDTLDSTA--AQQELRSKREQEVNILKK 1174
Query: 519 RAQASGSAHST--PNLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTS 576
+ H + V A E+ + ++ + G
Sbjct: 1175 TLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVK 1234
Query: 577 VKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVASALSRADR 636
V + SE + + Q + E E R + EL ++ V D
Sbjct: 1235 VLLQGKGDSEHKRKKVEAQLQELQVKFNEGE-RVRTELADK---------VTKLQVELDN 1284
Query: 637 EKAKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKA 696
+ ++ K S+L K A + Q++Q+ ++ +E R K+ L ++
Sbjct: 1285 VTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQ----------EENRQKLSLSTKLKQV 1334
Query: 697 KAEVDELRSRIRELEERDRRESKKIAD------------EDALRRIRQAEEQIEHLQRKL 744
+ E + R ++ E EE K+IA ED++ + AEE LQ+ L
Sbjct: 1335 EDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDL 1394
Query: 745 GATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLR 804
Q E ++ A++ +++ RL Q+L DD L +R A + K +
Sbjct: 1395 EGLSQRHEEKVA-------AYDKLEKTKTRLQQEL---DDLLVDLDHQRQSACNLEKKQK 1444
Query: 805 EEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRKAV 864
+ L E+ + + + EKE +E+ + +++ LNK+
Sbjct: 1445 KFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRT 1504
Query: 865 EAAQLAED-----------------LKVQLEHVQTRLREIQPCLAESRAAREKESFNLKR 907
E L L+ Q+E ++T+L E++ L + A+ + NL+
Sbjct: 1505 EMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQA 1564
Query: 908 AQEDISRLRRKLEKQRKVEVYADADEILQEEIKEYKARL 946
+ R + Q + E + + L +++E +A L
Sbjct: 1565 MKAQFER-----DLQGRDEQSEEKKKQLVRQVREMEAEL 1598
Score = 73.2 bits (178), Expect = 1e-12
Identities = 92/369 (24%), Positives = 169/369 (45%), Gaps = 56/369 (15%)
Query: 637 EKAKVEETKRKESELLK-GLRAELKKAQESQ-----------KEMKLLLDMYK----SAP 680
E+ + EE+ R++ +L K A+LKK +E Q KE KLL D +
Sbjct: 950 EQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLT 1009
Query: 681 KEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADE------DALRRIRQAE 734
+E+ L + K +A + +L R+R EE+ R+E +K + D +I + +
Sbjct: 1010 EEEEKSKSLAKLKNKHEAMITDLEERLRR-EEKQRQELEKTRRKLEGDSTDLSDQIAELQ 1068
Query: 735 EQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLM---- 790
QI L+ +L ++E +A L+ + E+ Q L+++RE + +L
Sbjct: 1069 AQIAELKMQLAKKEEELQAALARV-------EEEAAQKNMALKKIRELESQISELQEDLE 1121
Query: 791 SERIKANQIHKLLREEKDELGEQVLGLKSQVD-------AQLLTVQKLEEKERALQGSLG 843
SER N+ K +K +LGE++ LK++++ AQ K E++ L+ +L
Sbjct: 1122 SERASRNKAEK----QKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTL- 1176
Query: 844 GVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESF 903
E+ T +Q E+ ++ + +LAE L+ Q + V+ L + + L R E
Sbjct: 1177 -EEEAKTHEAQIQEMRQKHSQAVEELAEQLE-QTKRVKANLEKAKQTLENERGELANEVK 1234
Query: 904 NLKRAQEDISRLRRKLEKQ-RKVEVYADADEILQEEIKEYKARLTCPCCN-------TRK 955
L + + D R+K+E Q ++++V + E ++ E+ + +L N +
Sbjct: 1235 VLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDS 1294
Query: 956 KDAVLTKCF 964
K + LTK F
Sbjct: 1295 KSSKLTKDF 1303
Score = 68.9 bits (167), Expect = 2e-11
Identities = 154/827 (18%), Positives = 324/827 (39%), Gaps = 126/827 (15%)
Query: 60 AERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQ-LDETVEALLRCHESQGEL 118
A + E R E E+ + LE+ T +A + + + +Q ++E E L + + L
Sbjct: 1156 AAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANL 1215
Query: 119 SSAPEAPGTQEGPTCDGTP--LPEPGTSELR----DPLLMQLRPPLSEPALAFVVALGAS 172
A + + G + L G SE + + L +L+ +E
Sbjct: 1216 EKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKV 1275
Query: 173 SSEEVELE-LQGRMEFSKAAVSRVVEASDRLQRRV--------EELCQRVYSRGDSEPLS 223
+ +VEL+ + G + S + S++ + L+ ++ EE Q++ + +
Sbjct: 1276 TKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVE 1335
Query: 224 EAAQAHTRELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQ 283
+ + +L E +L Q+ H +++ +++D V ET E LQ
Sbjct: 1336 DEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETA----EEVKRKLQ 1391
Query: 284 WDIEKLRKREQ-------KLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLN 336
D+E L +R + KL K ++L+ V + +KF+ L
Sbjct: 1392 KDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDD-LLVDLDHQRQSACNLEKKQKKFDQLL 1450
Query: 337 AELEENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFS 396
AE ++ +++ AE E+ +AE + + + L +A R+L EE + + E L QF
Sbjct: 1451 AE----EKTISAKYAE-ERDRAEAEAREKETKALSLA-RAL-EEAMEQKAELERLNKQFR 1503
Query: 397 L-------------------------LYNESLQVKTQLDEARGLLLATKNSHLRHIEHME 431
L + ++KTQL+E L AT+++ LR +++
Sbjct: 1504 TEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQ 1563
Query: 432 SDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISSLQ 491
+ + ++ L+ Q E+ Q+ ++ + E E A +++ + L+
Sbjct: 1564 AMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLE 1623
Query: 492 NHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPAPGKEEGG 551
H + ++LR++QA++ + + S + A KE
Sbjct: 1624 AHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEI----------LAQAKE--- 1670
Query: 552 PGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPK 611
N K++ + + E++ +E+ + R + + +
Sbjct: 1671 --------NEKKLKSM-----------EAEMIQLQEELAA--------AERAKRQAQQER 1703
Query: 612 RELREREGPSLGPPPVA-SALSRADREKAKVEETKRKESELLKGLRAELKKAQESQKEMK 670
EL + S G +A R + A++EE +E + + LKKA ++
Sbjct: 1704 DELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQIN 1763
Query: 671 LLLDMYKSAP--------------KEQRDKVQLM--AAERKAKAEVDELRSRIRELEERD 714
L++ +S KE + K+Q M + K KA + L ++I +LEE+
Sbjct: 1764 TDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQL 1823
Query: 715 RRESKKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGR 774
E+K+ + A +++R+ E++++ + ++ ++ E + D + +
Sbjct: 1824 DNETKE--RQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLK-------Q 1874
Query: 775 LLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQV 821
L +QL E ++ + + R K + + E D + +V LK+++
Sbjct: 1875 LKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKL 1921
Score = 56.2 bits (134), Expect = 1e-07
Identities = 123/618 (19%), Positives = 245/618 (39%), Gaps = 97/618 (15%)
Query: 38 LGGISSTEEMDLKVLQFKNKKLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRY 97
+G + + EE+ K LQ + L++R E++ A D+L + +L+ Q DD L+V+
Sbjct: 1377 VGCLETAEEVKRK-LQKDLEGLSQRHEEKVAAYDKLEKTKTRLQ--QELDD---LLVD-- 1428
Query: 98 WAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDGTPLPEPGTSELRDPLLMQLRPP 157
LD ++ + Q + T +E RD + R
Sbjct: 1429 ---LDHQRQSACNLEKKQKKFDQLLAEEKTISAKY-----------AEERDRAEAEAREK 1474
Query: 158 LSEPALAFVVALGASSSEEVELELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYSRG 217
++ AL+ AL + ++ ELE + + + ++ + D + + V EL + S+
Sbjct: 1475 ETK-ALSLARALEEAMEQKAELERLNKQ--FRTEMEDLMSSKDDVGKSVHELEK---SKR 1528
Query: 218 DSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRISLEYS-ELQDKVTSAETK----- 271
E E + EL E + +D +L+ + ++ +LQ + +E K
Sbjct: 1529 ALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLV 1588
Query: 272 --VLEMETTVED--------------LQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSG 315
V EME +ED L+ D++ L NK+ EA++QL +
Sbjct: 1589 RQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRK---LQA 1645
Query: 316 SSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVRTNERLKVALR 375
+ E+L A+ +EN++ S AE+ +LQ EL A R + +
Sbjct: 1646 QMKDCMRELDDTRASREEIL-AQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERD 1704
Query: 376 SLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLL------------------- 416
L +E+ +G+ + + L Q++ +L+E +G
Sbjct: 1705 ELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINT 1764
Query: 417 -LATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTL------------AQVRKEYEMLR 463
L + SH + E+ K+L+ ++ ++E T+ A++ + E L
Sbjct: 1765 DLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLD 1824
Query: 464 IEFEQNLAANEQAGPINREMRHLISSLQNHN---HQLKGDAQRYKRKLREVQAEIGKLRA 520
E ++ AA +Q ++++ ++ + + Q K A + +L++++ ++ +
Sbjct: 1825 NETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEE 1884
Query: 521 QASGSAHSTPNLGHP-EDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKK 579
+A + S L ED+ +A A +E VS+ N+ +P +K
Sbjct: 1885 EAQRANASRRKLQRELEDATETADAMNRE------VSSLKNKLRRGDLP-FVVPRRMARK 1937
Query: 580 EELVPSEEDFQGITPGAQ 597
S+E+ G GA+
Sbjct: 1938 GAGDGSDEEVDGKADGAE 1955
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 96.3 bits (238), Expect = 1e-19
Identities = 158/840 (18%), Positives = 338/840 (40%), Gaps = 106/840 (12%)
Query: 173 SSEEVELELQGRMEFSKAAVSRVVEASDRLQRRVEELC----QRVYSRGDSEPLSEAAQA 228
S +E + ++ + V+ +++ + +L+++ ++L Q R D E +
Sbjct: 1002 SLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEG 1061
Query: 229 HTRELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAET-------KVLEMETTVED 281
+ L++ Q++EK + E S+LQ K+ + K+ E++ +E+
Sbjct: 1062 DLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEE 1121
Query: 282 LQWDIE---KLRKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAE 338
L+ +IE LR + +K LA LE+++ ++ E +
Sbjct: 1122 LEEEIEAEHTLRAKIEKQRSDLARELEEIS---------------------ERLEEASGA 1160
Query: 339 LEENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGE-YRMLQAQFSL 397
E+ R AE +K++ +L+ A +E LR + V E GE LQ
Sbjct: 1161 TSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQK 1220
Query: 398 LYNESLQVKTQLDEARGLLLATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRK 457
L E ++K ++D+ +IE + + +++ RT Q + A+ +
Sbjct: 1221 LEKEKSELKMEIDDMAS-----------NIEALSKSKSNIERTCRTVEDQFSEIKAKDEQ 1269
Query: 458 EYEMLRIEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGK 517
+ +++ Q Q N E+ H + ++ QL Q ++L E++ ++ +
Sbjct: 1270 QTQLIHDLNMQKARLQTQ----NGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEE 1325
Query: 518 LRAQASGSAHSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSV 577
+ AH+ + H D +E + E+A T
Sbjct: 1326 ETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQ 1385
Query: 578 KKEELVPSE----EDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVASALSR 633
+ EEL ++ + Q + +S+ E +R E E +A +
Sbjct: 1386 RTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACAT 1445
Query: 634 ADREKAKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAE 693
D+++ ++ + + L +AEL+ AQ+ + + L ++A +E D+++ + E
Sbjct: 1446 LDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRE 1505
Query: 694 RK-AKAEVDELRSRIRELEE--RDRRESKKIADE---DALRRIRQAEEQIEHLQRKLGAT 747
K + E+ +L +I E + ++ ++KK+ ++ D + + E +EH + K+
Sbjct: 1506 NKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRV 1565
Query: 748 KQEEEALLSEMD----VTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIK-ANQIHKL 802
+ E + SE+D + E ++ + R + L+ DA + ++ ++ ++
Sbjct: 1566 QLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGD 1625
Query: 803 LREEKDELGE-----------------QVLGLKSQVDAQLLTVQKLEEKERALQGSLGGV 845
L E + +LG Q+ + +D L + + L+E+ ++ G +
Sbjct: 1626 LNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLL 1685
Query: 846 EKELTLRSQALELNK--RKAVEAAQLAEDLKVQLEHVQTR----------------LREI 887
+EL ALE + R+ E L +VQL H Q E+
Sbjct: 1686 LEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEV 1745
Query: 888 QPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYAD-ADEILQEEIKEYKARL 946
+ + ESR A EK K+A D + + +L+K++ + + + L++ +K+ + RL
Sbjct: 1746 ENSIQESRNAEEK----AKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRL 1801
Score = 88.2 bits (217), Expect = 4e-17
Identities = 161/782 (20%), Positives = 315/782 (40%), Gaps = 89/782 (11%)
Query: 180 ELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYSR-GDSEPLSEAAQAHTRELGRENR 238
E + M K R E R + R +EL +++ S + L Q+ T L
Sbjct: 848 EAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEE 907
Query: 239 RLQDLA-------TQLQEKHHRISLEY---SELQDKVTSAETKVLEMETTVEDLQWDIEK 288
R + L +++E R+ E SEL K + E K ++ ++DL+ + K
Sbjct: 908 RCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTK 967
Query: 289 LRKREQKLN---KHLAEALEQL--NSGYYVSGSSSGFQGGQITLSMQKFE--------ML 335
+ K + K+L+E + L N S + Q TL + E +
Sbjct: 968 VEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKI 1027
Query: 336 NAELEENQELANSRMAELEKLQAELQGAVRTNE-RLKVALRSLPE-EVVRETGEYRMLQA 393
NA+LE+ + + + +KL+A+L+ A R E LK++ S+ + E ++ E ++ +
Sbjct: 1028 NAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKK 1087
Query: 394 QFSLLYNESLQVKTQLDEARGLLLATKNSHLR-HIEHMESDELGLQKKLRTEVIQLEDTL 452
+F L LQ K ++ L K L+ IE +E E I+ E TL
Sbjct: 1088 EFEL---SQLQAKIDDEQVHSLQFQKKIKELQARIEELE------------EEIEAEHTL 1132
Query: 453 -AQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREV 511
A++ K+ L E E+ E+A S+ N + + + Q+ +R L E
Sbjct: 1133 RAKIEKQRSDLARELEEISERLEEASGAT-------SAQIEMNKKREAEFQKMRRDLEEA 1185
Query: 512 ----QAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPV 567
+A LR + A S LG D+ ++E + D + +
Sbjct: 1186 TLQHEATAATLRKK---QADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEAL 1242
Query: 568 PGT------TTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPS 621
+ T T + E+ +E + +R + + E+E
Sbjct: 1243 SKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKES-- 1300
Query: 622 LGPPPVASALSRADRE-KAKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAP 680
+ S L+++ + ++EE KR+ E K A Q S+ + LL + Y+
Sbjct: 1301 -----LISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYE--- 1352
Query: 681 KEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHL 740
+EQ K +L A KA +EV + R++ E + R E + A + +R+++AEE E
Sbjct: 1353 EEQEAKAELQRALSKANSEVAQWRTKY-ETDAIQRTEELEEAKKKLAQRLQEAEENTETA 1411
Query: 741 QRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIH 800
K + ++ ++ L E++ + E L ++ R D + + ++
Sbjct: 1412 NSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAEL 1471
Query: 801 KLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNK 860
+ ++E L ++ +++ + + ++ L + + LQ + + +++ + L+ +
Sbjct: 1472 EAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAE 1531
Query: 861 RKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLE 920
+ Q DL+V LE V+ L E E + R Q ++S+++ +L+
Sbjct: 1532 KTKKLVEQEKSDLQVALEEVEGSL--------------EHEESKILRVQLELSQVKSELD 1577
Query: 921 KQ 922
++
Sbjct: 1578 RK 1579
Score = 80.5 bits (197), Expect = 7e-15
Identities = 164/783 (20%), Positives = 312/783 (39%), Gaps = 162/783 (20%)
Query: 180 ELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRR 239
EL R+E ++ +S++ ++ L +++EEL +++ + E ++ A AH + R +
Sbjct: 1290 ELSHRVEEKESLISQLTKSKQALTQQLEELKRQM----EEETKAKNAMAHALQSSRHDCD 1345
Query: 240 LQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTVE-DLQWDIEKLRKREQKLNK 298
L L+E++ +ELQ ++ A ++V + T E D E+L + ++KL +
Sbjct: 1346 L------LREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1399
Query: 299 HLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQA 358
L EA EEN E ANS+ A LEK +
Sbjct: 1400 RLQEA------------------------------------EENTETANSKCASLEKTKQ 1423
Query: 359 ELQGAV----RTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARG 414
LQG V R ER A +L ++ Q F + E K +LDE++
Sbjct: 1424 RLQGEVEDLMRDLERSHTACATLDKK-----------QRNFDKVLAE---WKQKLDESQA 1469
Query: 415 LLLATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANE 474
L A + + L TE+ ++ + +V + E LR +N E
Sbjct: 1470 ELEAAQKE---------------SRSLSTELFKMRNAYEEVVDQLETLR---RENKNLQE 1511
Query: 475 QAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGH 534
+ + ++ +LQ +A++ K+ + + ++++ + GS L H
Sbjct: 1512 EISDLTEQIAETGKNLQ--------EAEKTKKLVEQEKSDLQVALEEVEGS------LEH 1557
Query: 535 PEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITP 594
E + + E++ V K EE+ + + Q
Sbjct: 1558 EESKILRV------------------QLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAE 1599
Query: 595 GAQG---PSSRGREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESEL 651
Q R R R K+++ EG + L ++R+ A+ ++ R
Sbjct: 1600 ALQSVLDAEIRSRNDALRLKKKM---EGDL---NEMEIQLGHSNRQMAETQKHLRTVQGQ 1653
Query: 652 LKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELE 711
LK + L A S +++K L A E+R+ + L E++E++ + + E
Sbjct: 1654 LKDSQLHLDDALRSNEDLKEQL-----AIVERRNGLLL--------EELEEMKVALEQTE 1700
Query: 712 ERDRRESKKIAD-EDALRRIRQAEEQIEHLQRKLGA----TKQEEEALLSEMDVTGQAFE 766
R +++ D D ++ + + + ++KL A + E E + E + +
Sbjct: 1701 RTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAK 1760
Query: 767 DMQEQNGRLLQQLREKDDANFKLMSERIKAN--QIHKLLREEKDELGEQVL-GLKSQVDA 823
+ ++L+++ D + L ER+K N Q K L+ DE + L G K Q
Sbjct: 1761 KAITDAAMMAEELKKEQDTSAHL--ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQ--- 1815
Query: 824 QLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTR 883
+QKLE + R L+ L +K + +RK E AE+ + +Q
Sbjct: 1816 ----IQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDL 1871
Query: 884 LREIQPCL-AESRAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQEEIKEY 942
+ ++Q + + R A E E ++A +SR RR Q ++E A+ +I + ++ +
Sbjct: 1872 VDKLQAKVKSYKRQAEEAE----EQANTQLSRCRR---VQHELEEAAERADIAESQVNKL 1924
Query: 943 KAR 945
+A+
Sbjct: 1925 RAK 1927
Score = 58.2 bits (139), Expect = 4e-08
Identities = 68/330 (20%), Positives = 146/330 (44%), Gaps = 51/330 (15%)
Query: 631 LSRADREKAKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQ-L 689
L++ ++EK E + SE + L + K + +K ++ + + DKV L
Sbjct: 965 LTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGL 1024
Query: 690 MAAERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQRKL-GATK 748
+ K + + D+L E +L + ++ +E +RKL G K
Sbjct: 1025 IKINAKLEQQTDDL--------------------EGSLEQEKKLRADLERAKRKLEGDLK 1064
Query: 749 QEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEK- 807
+E+++ D++ ++ ++L++K+ +L + +I Q+H L ++K
Sbjct: 1065 MSQESIM-----------DLENDKQQIEEKLKKKEFELSQLQA-KIDDEQVHSLQFQKKI 1112
Query: 808 DELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQA----LELNKRKA 863
EL ++ L+ +++A+ K+E++ L L + + L S A +E+NK++
Sbjct: 1113 KELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKRE 1172
Query: 864 VEAAQLAEDL-KVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQ 922
E ++ DL + L+H T A R + L +++ R+++KLEK+
Sbjct: 1173 AEFQKMRRDLEEATLQHEAT--------AATLRKKQADSVAELGEQIDNLQRVKQKLEKE 1224
Query: 923 RKVEVYADADEILQ--EEIKEYKARLTCPC 950
K E+ + D++ E + + K+ + C
Sbjct: 1225 -KSELKMEIDDMASNIEALSKSKSNIERTC 1253
Score = 51.2 bits (121), Expect = 5e-06
Identities = 55/256 (21%), Positives = 125/256 (48%), Gaps = 12/256 (4%)
Query: 702 ELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVT 761
+++ ++ E + K E + ++E + + L+ K+ + QE+ L ++
Sbjct: 839 KIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSE 898
Query: 762 GQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQ-IHKLLREEKDELGEQVLGLKSQ 820
+ D +E+ L++ + +A K ++ER++ + ++ L +K L ++ LK
Sbjct: 899 TENLMDAEERCEGLIKS-KILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRD 957
Query: 821 VDAQLLTVQKLEEKERALQGSLGGVEKELT-LRSQALELNK-RKAVEAA--QLAEDLKVQ 876
+D LT+ K+E+++ A + + + +E+T L +L K +K+++ A Q +DL+V+
Sbjct: 958 IDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVE 1017
Query: 877 LEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYADAD---- 932
+ V L +I L + E K+ + D+ R +RKLE K+ + D
Sbjct: 1018 EDKV-NGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLEND 1076
Query: 933 -EILQEEIKEYKARLT 947
+ ++E++K+ + L+
Sbjct: 1077 KQQIEEKLKKKEFELS 1092
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 95.5 bits (236), Expect = 2e-19
Identities = 176/850 (20%), Positives = 349/850 (41%), Gaps = 127/850 (14%)
Query: 180 ELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYSRGDSEPLS-EAAQAHTRELGRENR 238
EL+ +E + A ++V + L R +EE+ +R+ G + + E + E + R
Sbjct: 1119 ELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRR 1178
Query: 239 RLQDLATQ-------LQEKHHRISLEYSELQDKVTSAETKV----LEMETTVEDLQWDIE 287
L++ Q L++KH E E D + + K+ E + ++D+ ++E
Sbjct: 1179 DLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNME 1238
Query: 288 KLRKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAEL----EENQ 343
++ K + L K ++ LE + Y V + T K + N EL EE +
Sbjct: 1239 QIIKAKANLEK-VSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKE 1297
Query: 344 ELAN-------SRMAELEKLQAELQGAVRTNERLKVALRS-------LPEEVVRETGEYR 389
L + S ++E L+ +L+ + L AL+S L E+ ET
Sbjct: 1298 ALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKA 1357
Query: 390 MLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHLRHIEHMESDELGLQKKLRT--EVIQ 447
LQ S +E Q +T+ + ++ E +E + L ++L+ E ++
Sbjct: 1358 ELQRVLSKANSEVAQWRTKYE----------TDAIQRTEELEEAKKKLAQRLQDAEEAVE 1407
Query: 448 --------LEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKG 499
LE T +++ E E L ++ E++ AA R +++ + + +
Sbjct: 1408 AVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQS 1467
Query: 500 DAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDS---GVSAPAPGKEEGGPGPVS 556
+ + +++ R + E+ KL+ S + +S EGG
Sbjct: 1468 ELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHE 1527
Query: 557 TPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGR----EPEARPKR 612
RK++ V+K EL + E+ + +G R + + +A +R
Sbjct: 1528 LEKVRKQL-----------EVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIER 1576
Query: 613 ELRERE--------GPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAEL----K 660
+L E++ + ++L R + +V K+K L + +L +
Sbjct: 1577 KLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANR 1636
Query: 661 KAQESQKEMKLLLDMYKSAPKEQRDKVQ--------LMAAERK---AKAEVDELRSRIRE 709
A E+QK++K L + K + D V+ + ER+ +AE++ELR+ + +
Sbjct: 1637 MAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQ 1696
Query: 710 LEERDRRESKKIADEDALR---RIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFE 766
E S+K+A+++ + R++ Q L + + + L SE++ Q
Sbjct: 1697 TER-----SRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECR 1751
Query: 767 DMQEQNGRLL-------QQLREKDDANFKLMSERIKAN--QIHKLLREEKDELGEQVL-G 816
+ +E+ + + ++L+++ D + L ER+K N Q K L+ DE + L G
Sbjct: 1752 NAEEKAKKAITDAAMMAEELKKEQDTSAHL--ERMKKNMEQTIKDLQHRLDEAEQIALKG 1809
Query: 817 LKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQ 876
K Q+ QKLE + R L+G L +K + + ++R+ E E+ K
Sbjct: 1810 GKKQL-------QKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKN 1862
Query: 877 LEHVQTRLREIQ-PCLAESRAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYADADEIL 935
L +Q + ++Q A R A E E ++A ++S+ R+ + + E AD I
Sbjct: 1863 LLRLQDLVDKLQLKVKAYKRQAEEAE----EQANTNLSKFRKVQHELDEAEERAD---IA 1915
Query: 936 QEEIKEYKAR 945
+ ++ + +A+
Sbjct: 1916 ESQVNKLRAK 1925
Score = 91.7 bits (226), Expect = 3e-18
Identities = 180/921 (19%), Positives = 376/921 (40%), Gaps = 160/921 (17%)
Query: 65 QRQACEDELRERIEKLEKRQATDDATLLIV----------NRYWAQLDETVEALLRCHES 114
Q QA +R +K+ +R+ DA L+I N W +L ++ LL+ E+
Sbjct: 791 QAQARGQLMRIEFKKIVERR---DALLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAET 847
Query: 115 QGELSSAPEAPGTQEGPTCDGTPLPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSS 174
+ E+++ E + G + E EL + ++ L+
Sbjct: 848 EKEMATMKE----EFGRIKETLEKSEARRKELEEKMVSLLQ-----------------EK 886
Query: 175 EEVELELQGRMEFSKAAVSR---VVEASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTR 231
+++L++Q + A R +++ +L+ +V+E+ +R+ E +
Sbjct: 887 NDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERL----------EDEEEMNA 936
Query: 232 ELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQWDIEKLRK 291
EL + R+L+D ++L++ + L ++++ + + E KV + + L I KL K
Sbjct: 937 ELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTK 996
Query: 292 REQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMA 351
++ L + +AL+ L E ++ L+ S++
Sbjct: 997 EKKALQEAHQQALDDLQ----------------------------VEEDKVNSLSKSKV- 1027
Query: 352 ELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDE 411
+LE+ +L+G++ +++++ L ++ G+ ++ Q L N+ LQ++ +L +
Sbjct: 1028 KLEQQVDDLEGSLEQEKKVRMDLERAKRKL---EGDLKLTQESIMDLENDKLQLEEKLKK 1084
Query: 412 ARGLLLATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQV------RKEYEMLRIE 465
+ N IE + L LQKKL+ ++E+ ++ R + E LR +
Sbjct: 1085 KEFDI----NQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSD 1140
Query: 466 FEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREV----QAEIGKLRAQ 521
+ L E+ E S N + + + Q+ +R L E +A LR +
Sbjct: 1141 LSREL---EEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKK 1197
Query: 522 ASGSAHSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPD-------------NRKEMAPVP 568
A S LG D+ ++E + D N ++++
Sbjct: 1198 ---HADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTL 1254
Query: 569 GTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVA 628
VK EE S DF T A+ + G R+L E+E +
Sbjct: 1255 EDQANEYRVKLEEAQRSLNDFT--TQRAKLQTENGELA-----RQLEEKEA-------LI 1300
Query: 629 SALSRADREKAK-VEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKV 687
S L+R + +E+ KR+ E K A Q ++ + LL + Y+ +E K
Sbjct: 1301 SQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYE---EETEAKA 1357
Query: 688 QLMAAERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGAT 747
+L KA +EV + R++ E + R E + A + +R++ AEE +E + K +
Sbjct: 1358 ELQRVLSKANSEVAQWRTKY-ETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSL 1416
Query: 748 KQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANF-KLMSE-RIKANQIHKLLRE 805
++ + L +E++ D++ N +K NF K+++E + K + L
Sbjct: 1417 EKTKHRLQNEIE---DLMVDVERSNAAAAAL--DKKQRNFDKILAEWKQKYEESQSELES 1471
Query: 806 EKDE---LGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRK 862
+ E L ++ LK+ + L ++ + + + LQ + + ++L
Sbjct: 1472 SQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLG------------ 1519
Query: 863 AVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQ 922
E + +L+ + ++ E+Q L E+ A+ E E + RAQ + ++++ ++E++
Sbjct: 1520 --EGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERK 1577
Query: 923 RKVEVYADADEILQEEIKEYK 943
A+ DE +++ + ++
Sbjct: 1578 -----LAEKDEEMEQAKRNHQ 1593
Score = 70.5 bits (171), Expect = 8e-12
Identities = 125/666 (18%), Positives = 270/666 (40%), Gaps = 92/666 (13%)
Query: 178 ELELQGRMEFSKA-AVSRVVEASDRLQRRVEELC------QRVYSRGDSEPLSEAAQAHT 230
+LE +G+ + + A A+ D L+ + EE QRV S+ +SE + T
Sbjct: 1320 QLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYET 1379
Query: 231 RELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQWDIEK-- 288
+ R L++ +L ++ + K +S E ++ +EDL D+E+
Sbjct: 1380 DAIQR-TEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSN 1438
Query: 289 -----LRKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQ 343
L K+++ +K LAE QK+E +ELE +Q
Sbjct: 1439 AAAAALDKKQRNFDKILAEW-------------------------KQKYEESQSELESSQ 1473
Query: 344 ELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEEV---VRETGE----YRMLQAQFS 396
+ A S EL KL+ + ++ E K ++L EE+ + GE L+
Sbjct: 1474 KEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRK 1533
Query: 397 LLYNESLQVKTQLDEARGLLLATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVR 456
L E L++++ L+EA L + LR + +++KL + ++E +
Sbjct: 1534 QLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQ 1593
Query: 457 KEYEMLRIEFEQNLAANEQAGPINREMRHLISSLQ---NHNHQLKGDAQRYKRKLREVQA 513
+ + L+ + + + + ++M ++ ++ +H +++ +AQ ++++ +Q+
Sbjct: 1594 RVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQ---KQVKSLQS 1650
Query: 514 EIGKLRAQASGSAHSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTT 573
+ + Q + + +L E+ + + +E+ V T
Sbjct: 1651 LLKDTQIQLDDAVRANDDL--KENIAIVERRNNLLQA---------ELEELRAVVEQTER 1699
Query: 574 TTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVASALSR 633
+ + ++EL+ + E Q + ++ + +++ + S +
Sbjct: 1700 SRKLAEQELIETSERVQLL--------------HSQNTSLINQKKKMESDLTQLQSEVEE 1745
Query: 634 ADREKAKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQ--LMA 691
A +E EE +K + ELKK Q++ ++ + + K+ + ++
Sbjct: 1746 AVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQI 1805
Query: 692 AERKAKAEVDELRSRIRELEERDRRESKKIAD-----EDALRRIRQAEEQIEHLQRKLGA 746
A + K ++ +L +R+RELE E K+ A+ + RRI++ Q E ++ L
Sbjct: 1806 ALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLR 1865
Query: 747 TKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLR----EKDDANFKLMSERIKANQIHKL 802
+ + L ++ + E+ +EQ L + R E D+A + I +Q++KL
Sbjct: 1866 LQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEER---ADIAESQVNKL 1922
Query: 803 LREEKD 808
+ +D
Sbjct: 1923 RAKSRD 1928
Score = 66.6 bits (161), Expect = 1e-10
Identities = 94/420 (22%), Positives = 193/420 (45%), Gaps = 72/420 (17%)
Query: 579 KEELVPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVASALSRADRE- 637
++E+ +E+F I + +R +E E + L+E+ L L+ A+
Sbjct: 848 EKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERC 907
Query: 638 ----------KAKVEETKRK---ESELLKGLRAELKKAQESQKEMKLLLD-MYKSAPKEQ 683
+AKV+E + E E+ L A+ +K ++ E+K +D + + K +
Sbjct: 908 DQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVE 967
Query: 684 RDKVQLMAAERKAK------AEVDELRSRIRELEERDRRESKKIA------DEDALRRIR 731
++K A E K K A +DE+ +++ + E++ +E+ + A +ED + +
Sbjct: 968 KEK---HATENKVKNLTEEMAGLDEIIAKLTK-EKKALQEAHQQALDDLQVEEDKVNSLS 1023
Query: 732 QA----EEQIEHLQRKLGATKQ-------EEEALLSEMDVTGQAFEDMQEQNGRLLQQLR 780
++ E+Q++ L+ L K+ + L ++ +T ++ D++ +L ++L+
Sbjct: 1024 KSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLK 1083
Query: 781 EKD----DANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKER 836
+K+ N K+ E++ A Q+ K L+E + + E L+ +++A+ K+E+
Sbjct: 1084 KKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEE----LEEELEAERTARAKVEKLRS 1139
Query: 837 ALQGSLGGVEKELT----LRSQALELNKRKAVEAAQLAEDL-KVQLEHVQTRLREIQPCL 891
L L + + L S +E+NK++ E ++ DL + L+H T
Sbjct: 1140 DLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEAT--------- 1190
Query: 892 AESRAAREKESFNLKRAQEDISRLRR---KLEKQRKVEVYADADEIL--QEEIKEYKARL 946
+ A R+K + ++ E I L+R KLEK+ K E + D++ E+I + KA L
Sbjct: 1191 --AAALRKKHADSVAELGEQIDNLQRVKQKLEKE-KSEFKLELDDVTSNMEQIIKAKANL 1247
Score = 49.7 bits (117), Expect = 1e-05
Identities = 72/303 (23%), Positives = 136/303 (44%), Gaps = 41/303 (13%)
Query: 659 LKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRES 718
L K+ E++KEM + + + R K L +E + K E++E + L+E++ +
Sbjct: 841 LLKSAETEKEMATMKEEFG------RIKETLEKSEARRK-ELEE--KMVSLLQEKNDLQL 891
Query: 719 KKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQ 778
+ A++D L AEE+ + L + K + EA + EM+ + ED +E N L +
Sbjct: 892 QVQAEQDNLN---DAEERCDQLIKN----KIQLEAKVKEMN---ERLEDEEEMNAELTAK 941
Query: 779 LREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERAL 838
R+ +D +L + + +EK +V L ++ + KL ++++AL
Sbjct: 942 KRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKAL 1001
Query: 839 QGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAR 898
Q + +L + + + V+ Q +DL+ LE + +++ RA R
Sbjct: 1002 QEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLE------RAKR 1055
Query: 899 EKESFNLKRAQEDIS-------RLRRKLEKQR--------KVEVYADADEILQEEIKEYK 943
+ E +LK QE I +L KL+K+ K+E LQ+++KE +
Sbjct: 1056 KLEG-DLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQ 1114
Query: 944 ARL 946
AR+
Sbjct: 1115 ARI 1117
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 94.4 bits (233), Expect = 5e-19
Identities = 203/1012 (20%), Positives = 394/1012 (38%), Gaps = 165/1012 (16%)
Query: 21 KLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNK--KLAERLEQRQACEDELRERIE 78
KLS+E K I + ++ EE + + KNK + LE R E++ R+ +E
Sbjct: 996 KLSKERKLLEERISDLTTN-LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1054
Query: 79 KLEKRQATD-----------DATLLIVNRYWAQLDETVEALL---------------RCH 112
KL+++ D A + + A+ +E ++A L +
Sbjct: 1055 KLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR 1114
Query: 113 ESQGELSSAPEAPGTQEGPTCDGTPLPEPGTSELRDPLLMQLRPPLSEPALAFVVALGAS 172
E +G +S E ++ EL + L +L L A L A
Sbjct: 1115 ELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL-EALKTELEDTLDSTATQ--QELRAK 1171
Query: 173 SSEEVELELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVY----SRGDSEPLSEAAQA 228
+EV + + E +++ ++V E + + VEEL +++ ++ + + + +
Sbjct: 1172 REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK 1231
Query: 229 HTRELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQWDIEK 288
+L E R L +++ K ++ + ELQ K + E E+ V LQ ++E
Sbjct: 1232 ENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVES 1291
Query: 289 L-------RKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFE-------- 333
+ + KL K +A QL + + Q ++ +++ E
Sbjct: 1292 VTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR-QKLNVSTKLRQLEEERNSLQD 1350
Query: 334 MLNAELEENQELA---NSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRM 390
L+ E+E Q L ++ +L + +LQ T E L+ + +E+ T +Y
Sbjct: 1351 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE 1410
Query: 391 LQAQFSLLYNESLQVKTQLDEA------RGLLLATKNSHLRHIEHMESDELGLQKKLRTE 444
A + L +++ +LD+ + L++ R + + ++E + K E
Sbjct: 1411 KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADE 1470
Query: 445 VIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINR----EMRHLISS----------L 490
+ E + + L E+ L A E+ N+ EM L+SS L
Sbjct: 1471 RDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1530
Query: 491 QNHNHQLKGDAQRYKRKLREVQAEI-----GKLRAQASGSA---HSTPNLGHPEDSGVSA 542
+ L+ + K +L E++ E+ KLR + + A +L ++
Sbjct: 1531 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1590
Query: 543 PAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSS- 601
+ + D RK+ A + K++L +D + Q S+
Sbjct: 1591 RRQLQRQLHEYETELEDERKQRA--------LAAAAKKKLEGDLKDLE-----LQADSAI 1637
Query: 602 RGREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAELKK 661
+GRE + R+L+ + L A + ++ T ++ + K L A+L +
Sbjct: 1638 KGREEAIKQLRKLQAQM------KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1691
Query: 662 AQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDE----LRSRIRELEERDRRE 717
QE ++ K A E+ + + +A+ + + + L +RI +LEE E
Sbjct: 1692 LQE---DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1748
Query: 718 SKKIADEDALRRIRQAEEQIEHLQRKLG---ATKQEEEALLSEMDVTGQAFEDMQEQNGR 774
+ E R+R+A +Q E L +L +T Q+ E+ A + ++ QN
Sbjct: 1749 QGNM--EAMSDRVRKATQQAEQLSNELATERSTAQKNES----------ARQQLERQNKE 1796
Query: 775 LLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEK 834
L +L E + A I A L + +L EQV + + + + L++K
Sbjct: 1797 LRSKLHEMEGAVKSKFKSTIAA------LEAKIAQLEEQV---EQEAREKQAATKSLKQK 1847
Query: 835 ERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAES 894
++ L+ L VE E ++AE K Q E R+++++ L E+
Sbjct: 1848 DKKLKEILLQVEDE------------------RKMAEQYKEQAEKGNARVKQLKRQLEEA 1889
Query: 895 RAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQEEIKEYKARL 946
E+ES + I+ RRKL QR+++ +++E + E+ K++L
Sbjct: 1890 ----EEES-------QRINANRRKL--QRELDEATESNEAMGREVNALKSKL 1928
Score = 80.9 bits (198), Expect = 6e-15
Identities = 149/809 (18%), Positives = 317/809 (39%), Gaps = 112/809 (13%)
Query: 201 RLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRISLEYSE 260
++ R+ EE+ + ++ + A+ +EL +++ +L + LQE+ + Y+E
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 261 LQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQ-------------------------- 294
++ K E+E + +++ +E+ R Q
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965
Query: 295 ----KLNKHLAEA-LEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQE----- 344
+L K AEA +++L V + + L ++ L L E +E
Sbjct: 966 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL 1025
Query: 345 --LANSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNES 402
L N + + +L+ L+ ++ + L+ R L + + LQAQ + L +
Sbjct: 1026 TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQL 1085
Query: 403 LQVKTQLDEARGLL---LATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVR--- 456
+ + +L A L +A KN+ L+ I +E LQ+ L +E Q R
Sbjct: 1086 AKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1145
Query: 457 KEYEMLRIEFEQNL--AANEQAGPINREM------RHLISSLQNHNHQLKGDAQRYKRKL 508
+E E L+ E E L A +Q RE + L ++H Q++ Q++ + +
Sbjct: 1146 EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV 1205
Query: 509 REVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVP 568
E+ ++ + + +A + E++ ++ V
Sbjct: 1206 EELTEQLEQFK-RAKANLDKNKQTLEKENADLAGE---------------------LRVL 1243
Query: 569 GTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRE-------LREREGPS 621
G KK++L ++ Q + + + + + E L E EG +
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1303
Query: 622 LGPPPVASALSR--ADREKAKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSA 679
+ ++LS D ++ EET++K + +L++ +E + ++ LD A
Sbjct: 1304 IKLAKDVASLSSQLQDTQELLQEETRQK-----LNVSTKLRQLEEERNSLQDQLDEEMEA 1358
Query: 680 PKEQRDKVQLMAAE-RKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIE 738
+ + + + +K ++ + S + LEE +R K+I E+ ++ + +
Sbjct: 1359 KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI--ENLTQQYEEKAAAYD 1416
Query: 739 HLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQ 798
L++ +QE + L+ ++D Q +++++ + Q L E+ + + K ER +A
Sbjct: 1417 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA-- 1474
Query: 799 IHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGG-VEKELTLRSQALE 857
E E + L L ++ L ++LE + L+ + V + + E
Sbjct: 1475 -----EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1529
Query: 858 LNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRR 917
L K K L+ Q+E ++T+L E++ L + A+ + N++ + R
Sbjct: 1530 LEKSKRA--------LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER--- 1578
Query: 918 KLEKQRKVEVYADADEILQEEIKEYKARL 946
+ Q + E + LQ ++ EY+ L
Sbjct: 1579 --DLQARDEQNEEKRRQLQRQLHEYETEL 1605
Score = 80.9 bits (198), Expect = 6e-15
Identities = 158/809 (19%), Positives = 315/809 (38%), Gaps = 92/809 (11%)
Query: 19 EKKLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNKK----------------LAER 62
+K L E ++ ++ +R + EE+ ++ QFK K LA
Sbjct: 1180 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1239
Query: 63 LEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAP 122
L + E+ + +KLE + + R A+L++ V H+ Q E+ S
Sbjct: 1240 LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKV------HKLQNEVESVT 1293
Query: 123 EAPGTQEGPTCDGTPLPEPGTSELRDPL-LMQLRPPLSEPALAFVVALGASSSEEVELEL 181
EG +S+L+D L+Q E V+ EE L
Sbjct: 1294 GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ-----EETRQKLNVSTKLRQLEEERNSL 1348
Query: 182 QGRMEFSKAAVSRVVEASDRLQRRVEEL-CQRVYSRGDSEPLSEAAQAHTRELGRENRRL 240
Q +++ +EA L+R + L Q S+ + + +A R + +
Sbjct: 1349 QDQLD-------EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI 1401
Query: 241 QDLATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHL 300
++L Q +EK + Y +L+ + ++ ++ +++ + + L K+++K ++ L
Sbjct: 1402 ENLTQQYEEK----AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1457
Query: 301 AEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAEL 360
AE + ++S Y + + AE E + A S LE+
Sbjct: 1458 AEE-KNISSKY-----------------ADERDRAEAEAREKETKALSLARALEEALEAK 1499
Query: 361 QGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATK 420
+ RTN+ LK + L L+ L + ++KTQL+E L AT+
Sbjct: 1500 EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE 1559
Query: 421 NSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPIN 480
++ LR +M++ + ++ L+ Q E+ Q++++ E E A
Sbjct: 1560 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAK 1619
Query: 481 REMRHLISSLQ-NHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSG 539
+++ + L+ + +KG + K+ LR++QA++ + + + S
Sbjct: 1620 KKLEGDLKDLELQADSAIKGREEAIKQ-LRKLQAQMKDFQRELEDARASRDE-------- 1670
Query: 540 VSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGP 599
+ A A E+ + +E ++KEEL E+ G
Sbjct: 1671 IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA---EELASSLSGRNAL 1727
Query: 600 SSRGREPEARP---KRELREREGPSLGPPP-VASALSRAD---------REKAKVEETKR 646
R EAR + EL E +G V A +A+ R A+ E+ R
Sbjct: 1728 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR 1787
Query: 647 KESELL-KGLRAELKKAQESQK-EMKLLLDMYKSAPKEQRDKVQLMAAERKAKAE-VDEL 703
++ E K LR++L + + + K + K + ++ + ++V+ A E++A + + +
Sbjct: 1788 QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1847
Query: 704 RSRIREL-----EERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEM 758
+++E+ +ER E K E R++Q + Q+E + + L E+
Sbjct: 1848 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1907
Query: 759 DVTGQAFEDMQEQNGRLLQQLREKDDANF 787
D ++ E M + L +LR ++ +F
Sbjct: 1908 DEATESNEAMGREVNALKSKLRRGNETSF 1936
Score = 63.5 bits (153), Expect = 9e-10
Identities = 78/301 (25%), Positives = 146/301 (48%), Gaps = 40/301 (13%)
Query: 668 EMKLLLDMYKSAPKEQRDKVQLMAA-ERKAKAEVDELRSRIRELEERDRRESKKIADEDA 726
++K LL + + + Q + +L ER+ KAE EL+E +++ S+ +++
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAE--------NELKELEQKHSQLTEEKNL 891
Query: 727 LRRIRQAEEQI----EHLQRKLGATKQEEEALLSEMDVTGQAFED-----------MQEQ 771
L+ QAE ++ E ++ +L A KQE E +L EM+ + ED M +Q
Sbjct: 892 LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 951
Query: 772 NGRLLQQLREKDDANFKLMSERIKANQIHKLLREE---KDELGEQVLGLKSQVDAQL--L 826
L +QL E++ A KL E++ A K L +E D+ ++ + ++ ++ L
Sbjct: 952 MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1011
Query: 827 TVQKLEEKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLE----HVQT 882
T EE+E+A +L ++ + LE+ +K ++ Q E LK +LE
Sbjct: 1012 TTNLAEEEEKA--KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1069
Query: 883 RLREIQPCLAESR---AAREKE-SFNLKRAQEDISRLRRKLEKQRKVEVY-ADADEILQE 937
++ ++Q +AE + A +E+E L R ++I++ L+K R++E + +D E L
Sbjct: 1070 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1129
Query: 938 E 938
E
Sbjct: 1130 E 1130
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 94.4 bits (233), Expect = 5e-19
Identities = 203/1012 (20%), Positives = 394/1012 (38%), Gaps = 165/1012 (16%)
Query: 21 KLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNK--KLAERLEQRQACEDELRERIE 78
KLS+E K I + ++ EE + + KNK + LE R E++ R+ +E
Sbjct: 1003 KLSKERKLLEERISDLTTN-LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1061
Query: 79 KLEKRQATD-----------DATLLIVNRYWAQLDETVEALL---------------RCH 112
KL+++ D A + + A+ +E ++A L +
Sbjct: 1062 KLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR 1121
Query: 113 ESQGELSSAPEAPGTQEGPTCDGTPLPEPGTSELRDPLLMQLRPPLSEPALAFVVALGAS 172
E +G +S E ++ EL + L +L L A L A
Sbjct: 1122 ELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL-EALKTELEDTLDSTATQ--QELRAK 1178
Query: 173 SSEEVELELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVY----SRGDSEPLSEAAQA 228
+EV + + E +++ ++V E + + VEEL +++ ++ + + + +
Sbjct: 1179 REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK 1238
Query: 229 HTRELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQWDIEK 288
+L E R L +++ K ++ + ELQ K + E E+ V LQ ++E
Sbjct: 1239 ENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVES 1298
Query: 289 L-------RKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFE-------- 333
+ + KL K +A QL + + Q ++ +++ E
Sbjct: 1299 VTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR-QKLNVSTKLRQLEEERNSLQD 1357
Query: 334 MLNAELEENQELA---NSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRM 390
L+ E+E Q L ++ +L + +LQ T E L+ + +E+ T +Y
Sbjct: 1358 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE 1417
Query: 391 LQAQFSLLYNESLQVKTQLDEA------RGLLLATKNSHLRHIEHMESDELGLQKKLRTE 444
A + L +++ +LD+ + L++ R + + ++E + K E
Sbjct: 1418 KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADE 1477
Query: 445 VIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINR----EMRHLISS----------L 490
+ E + + L E+ L A E+ N+ EM L+SS L
Sbjct: 1478 RDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1537
Query: 491 QNHNHQLKGDAQRYKRKLREVQAEI-----GKLRAQASGSA---HSTPNLGHPEDSGVSA 542
+ L+ + K +L E++ E+ KLR + + A +L ++
Sbjct: 1538 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1597
Query: 543 PAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSS- 601
+ + D RK+ A + K++L +D + Q S+
Sbjct: 1598 RRQLQRQLHEYETELEDERKQRA--------LAAAAKKKLEGDLKDLE-----LQADSAI 1644
Query: 602 RGREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAELKK 661
+GRE + R+L+ + L A + ++ T ++ + K L A+L +
Sbjct: 1645 KGREEAIKQLRKLQAQM------KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1698
Query: 662 AQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDE----LRSRIRELEERDRRE 717
QE ++ K A E+ + + +A+ + + + L +RI +LEE E
Sbjct: 1699 LQE---DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1755
Query: 718 SKKIADEDALRRIRQAEEQIEHLQRKLG---ATKQEEEALLSEMDVTGQAFEDMQEQNGR 774
+ E R+R+A +Q E L +L +T Q+ E+ A + ++ QN
Sbjct: 1756 QGNM--EAMSDRVRKATQQAEQLSNELATERSTAQKNES----------ARQQLERQNKE 1803
Query: 775 LLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEK 834
L +L E + A I A L + +L EQV + + + + L++K
Sbjct: 1804 LRSKLHEMEGAVKSKFKSTIAA------LEAKIAQLEEQV---EQEAREKQAATKSLKQK 1854
Query: 835 ERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAES 894
++ L+ L VE E ++AE K Q E R+++++ L E+
Sbjct: 1855 DKKLKEILLQVEDE------------------RKMAEQYKEQAEKGNARVKQLKRQLEEA 1896
Query: 895 RAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQEEIKEYKARL 946
E+ES + I+ RRKL QR+++ +++E + E+ K++L
Sbjct: 1897 ----EEES-------QRINANRRKL--QRELDEATESNEAMGREVNALKSKL 1935
Score = 80.9 bits (198), Expect = 6e-15
Identities = 149/809 (18%), Positives = 317/809 (39%), Gaps = 112/809 (13%)
Query: 201 RLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRISLEYSE 260
++ R+ EE+ + ++ + A+ +EL +++ +L + LQE+ + Y+E
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 261 LQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQ-------------------------- 294
++ K E+E + +++ +E+ R Q
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972
Query: 295 ----KLNKHLAEA-LEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQE----- 344
+L K AEA +++L V + + L ++ L L E +E
Sbjct: 973 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL 1032
Query: 345 --LANSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNES 402
L N + + +L+ L+ ++ + L+ R L + + LQAQ + L +
Sbjct: 1033 TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQL 1092
Query: 403 LQVKTQLDEARGLL---LATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVR--- 456
+ + +L A L +A KN+ L+ I +E LQ+ L +E Q R
Sbjct: 1093 AKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1152
Query: 457 KEYEMLRIEFEQNL--AANEQAGPINREM------RHLISSLQNHNHQLKGDAQRYKRKL 508
+E E L+ E E L A +Q RE + L ++H Q++ Q++ + +
Sbjct: 1153 EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV 1212
Query: 509 REVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVP 568
E+ ++ + + +A + E++ ++ V
Sbjct: 1213 EELTEQLEQFK-RAKANLDKNKQTLEKENADLAGE---------------------LRVL 1250
Query: 569 GTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRE-------LREREGPS 621
G KK++L ++ Q + + + + + E L E EG +
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1310
Query: 622 LGPPPVASALSR--ADREKAKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSA 679
+ ++LS D ++ EET++K + +L++ +E + ++ LD A
Sbjct: 1311 IKLAKDVASLSSQLQDTQELLQEETRQK-----LNVSTKLRQLEEERNSLQDQLDEEMEA 1365
Query: 680 PKEQRDKVQLMAAE-RKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIE 738
+ + + + +K ++ + S + LEE +R K+I E+ ++ + +
Sbjct: 1366 KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI--ENLTQQYEEKAAAYD 1423
Query: 739 HLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQ 798
L++ +QE + L+ ++D Q +++++ + Q L E+ + + K ER +A
Sbjct: 1424 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA-- 1481
Query: 799 IHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGG-VEKELTLRSQALE 857
E E + L L ++ L ++LE + L+ + V + + E
Sbjct: 1482 -----EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1536
Query: 858 LNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRR 917
L K K L+ Q+E ++T+L E++ L + A+ + N++ + R
Sbjct: 1537 LEKSKRA--------LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER--- 1585
Query: 918 KLEKQRKVEVYADADEILQEEIKEYKARL 946
+ Q + E + LQ ++ EY+ L
Sbjct: 1586 --DLQARDEQNEEKRRQLQRQLHEYETEL 1612
Score = 80.9 bits (198), Expect = 6e-15
Identities = 158/809 (19%), Positives = 315/809 (38%), Gaps = 92/809 (11%)
Query: 19 EKKLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNKK----------------LAER 62
+K L E ++ ++ +R + EE+ ++ QFK K LA
Sbjct: 1187 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1246
Query: 63 LEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAP 122
L + E+ + +KLE + + R A+L++ V H+ Q E+ S
Sbjct: 1247 LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKV------HKLQNEVESVT 1300
Query: 123 EAPGTQEGPTCDGTPLPEPGTSELRDPL-LMQLRPPLSEPALAFVVALGASSSEEVELEL 181
EG +S+L+D L+Q E V+ EE L
Sbjct: 1301 GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ-----EETRQKLNVSTKLRQLEEERNSL 1355
Query: 182 QGRMEFSKAAVSRVVEASDRLQRRVEEL-CQRVYSRGDSEPLSEAAQAHTRELGRENRRL 240
Q +++ +EA L+R + L Q S+ + + +A R + +
Sbjct: 1356 QDQLD-------EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI 1408
Query: 241 QDLATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHL 300
++L Q +EK + Y +L+ + ++ ++ +++ + + L K+++K ++ L
Sbjct: 1409 ENLTQQYEEK----AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464
Query: 301 AEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAEL 360
AE + ++S Y + + AE E + A S LE+
Sbjct: 1465 AEE-KNISSKY-----------------ADERDRAEAEAREKETKALSLARALEEALEAK 1506
Query: 361 QGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATK 420
+ RTN+ LK + L L+ L + ++KTQL+E L AT+
Sbjct: 1507 EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE 1566
Query: 421 NSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPIN 480
++ LR +M++ + ++ L+ Q E+ Q++++ E E A
Sbjct: 1567 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAK 1626
Query: 481 REMRHLISSLQ-NHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSG 539
+++ + L+ + +KG + K+ LR++QA++ + + + S
Sbjct: 1627 KKLEGDLKDLELQADSAIKGREEAIKQ-LRKLQAQMKDFQRELEDARASRDE-------- 1677
Query: 540 VSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGP 599
+ A A E+ + +E ++KEEL E+ G
Sbjct: 1678 IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA---EELASSLSGRNAL 1734
Query: 600 SSRGREPEARP---KRELREREGPSLGPPP-VASALSRAD---------REKAKVEETKR 646
R EAR + EL E +G V A +A+ R A+ E+ R
Sbjct: 1735 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR 1794
Query: 647 KESELL-KGLRAELKKAQESQK-EMKLLLDMYKSAPKEQRDKVQLMAAERKAKAE-VDEL 703
++ E K LR++L + + + K + K + ++ + ++V+ A E++A + + +
Sbjct: 1795 QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1854
Query: 704 RSRIREL-----EERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEM 758
+++E+ +ER E K E R++Q + Q+E + + L E+
Sbjct: 1855 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1914
Query: 759 DVTGQAFEDMQEQNGRLLQQLREKDDANF 787
D ++ E M + L +LR ++ +F
Sbjct: 1915 DEATESNEAMGREVNALKSKLRRGNETSF 1943
Score = 63.5 bits (153), Expect = 9e-10
Identities = 78/301 (25%), Positives = 146/301 (48%), Gaps = 40/301 (13%)
Query: 668 EMKLLLDMYKSAPKEQRDKVQLMAA-ERKAKAEVDELRSRIRELEERDRRESKKIADEDA 726
++K LL + + + Q + +L ER+ KAE EL+E +++ S+ +++
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAE--------NELKELEQKHSQLTEEKNL 898
Query: 727 LRRIRQAEEQI----EHLQRKLGATKQEEEALLSEMDVTGQAFED-----------MQEQ 771
L+ QAE ++ E ++ +L A KQE E +L EM+ + ED M +Q
Sbjct: 899 LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 958
Query: 772 NGRLLQQLREKDDANFKLMSERIKANQIHKLLREE---KDELGEQVLGLKSQVDAQL--L 826
L +QL E++ A KL E++ A K L +E D+ ++ + ++ ++ L
Sbjct: 959 MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1018
Query: 827 TVQKLEEKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLE----HVQT 882
T EE+E+A +L ++ + LE+ +K ++ Q E LK +LE
Sbjct: 1019 TTNLAEEEEKA--KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1076
Query: 883 RLREIQPCLAESR---AAREKE-SFNLKRAQEDISRLRRKLEKQRKVEVY-ADADEILQE 937
++ ++Q +AE + A +E+E L R ++I++ L+K R++E + +D E L
Sbjct: 1077 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1136
Query: 938 E 938
E
Sbjct: 1137 E 1137
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.128 0.344
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,899,536
Number of Sequences: 37866
Number of extensions: 1948705
Number of successful extensions: 23871
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 410
Number of HSP's successfully gapped in prelim test: 1468
Number of HSP's that attempted gapping in prelim test: 11495
Number of HSP's gapped (non-prelim): 8033
length of query: 1001
length of database: 18,247,518
effective HSP length: 112
effective length of query: 889
effective length of database: 14,006,526
effective search space: 12451801614
effective search space used: 12451801614
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.