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Search of human proteins with 71852584
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|71852584 arylsulfatase D isoform a precursor [Homo sapiens]
(593 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|71852584 arylsulfatase D isoform a precursor [Homo sapiens] 1260 0.0
gi|58743319 arylsulfatase family, member H [Homo sapiens] 781 0.0
gi|157266309 arylsulfatase E precursor [Homo sapiens] 771 0.0
gi|31742482 arylsulfatase F precursor [Homo sapiens] 723 0.0
gi|71852586 arylsulfatase D isoform b precursor [Homo sapiens] 694 0.0
gi|53831991 steryl-sulfatase precursor [Homo sapiens] 587 e-167
gi|4503899 galactosamine (N-acetyl)-6-sulfate sulfatase precurso... 245 7e-65
gi|45430057 Arylsulfatase G [Homo sapiens] 136 6e-32
gi|38569407 arylsulfatase B isoform 2 precursor [Homo sapiens] 129 1e-29
gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens] 129 1e-29
gi|146229331 arylsulfatase A isoform a precursor [Homo sapiens] 124 2e-28
gi|146229329 arylsulfatase A isoform a precursor [Homo sapiens] 124 2e-28
gi|146229324 arylsulfatase A isoform a precursor [Homo sapiens] 124 2e-28
gi|6005990 arylsulfatase A isoform a precursor [Homo sapiens] 124 2e-28
gi|59797060 arylsulfatase family, member I [Homo sapiens] 120 3e-27
gi|146229327 arylsulfatase A isoform b [Homo sapiens] 112 7e-25
gi|109389362 arylsulfatase J [Homo sapiens] 94 3e-19
gi|4557659 iduronate-2-sulfatase isoform a precursor [Homo sapiens] 91 2e-18
gi|5360208 iduronate-2-sulfatase isoform b precursor [Homo sapiens] 86 1e-16
gi|4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo sap... 62 2e-09
gi|39930577 arylsulfatase K [Homo sapiens] 53 9e-07
gi|169217295 PREDICTED: similar to iduronate 2-sulfatase (Hunter... 50 6e-06
gi|189571643 sulfatase 1 [Homo sapiens] 48 3e-05
gi|189571641 sulfatase 1 [Homo sapiens] 48 3e-05
gi|189571638 sulfatase 1 [Homo sapiens] 48 3e-05
gi|189571636 sulfatase 1 [Homo sapiens] 48 3e-05
gi|240255483 sulfatase 2 isoform a precursor [Homo sapiens] 44 5e-04
gi|240255478 sulfatase 2 isoform b precursor [Homo sapiens] 44 5e-04
gi|29789100 sulfatase 2 isoform a precursor [Homo sapiens] 44 5e-04
gi|4504061 glucosamine (N-acetyl)-6-sulfatase precursor [Homo sa... 44 5e-04
>gi|71852584 arylsulfatase D isoform a precursor [Homo sapiens]
Length = 593
Score = 1260 bits (3260), Expect = 0.0
Identities = 593/593 (100%), Positives = 593/593 (100%)
Query: 1 MRSAARRGRAAPAARDSLPVLLFLCLLLKTCEPKTANAFKPNILLIMADDLGTGDLGCYG 60
MRSAARRGRAAPAARDSLPVLLFLCLLLKTCEPKTANAFKPNILLIMADDLGTGDLGCYG
Sbjct: 1 MRSAARRGRAAPAARDSLPVLLFLCLLLKTCEPKTANAFKPNILLIMADDLGTGDLGCYG 60
Query: 61 NNTLRTPNIDQLAEEGVRLTQHLAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWNA 120
NNTLRTPNIDQLAEEGVRLTQHLAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWNA
Sbjct: 61 NNTLRTPNIDQLAEEGVRLTQHLAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWNA 120
Query: 121 GSGGLPENETTFARILQQHGYATGLIGKWHQGVNCASRGDHCHHPLNHGFDYFYGMPFTL 180
GSGGLPENETTFARILQQHGYATGLIGKWHQGVNCASRGDHCHHPLNHGFDYFYGMPFTL
Sbjct: 121 GSGGLPENETTFARILQQHGYATGLIGKWHQGVNCASRGDHCHHPLNHGFDYFYGMPFTL 180
Query: 181 TNDCDPGRPPEVDAALRAQLWGYTQFLALGILTLAAGQTCGFFSVSARAVTGMAGVGCLF 240
TNDCDPGRPPEVDAALRAQLWGYTQFLALGILTLAAGQTCGFFSVSARAVTGMAGVGCLF
Sbjct: 181 TNDCDPGRPPEVDAALRAQLWGYTQFLALGILTLAAGQTCGFFSVSARAVTGMAGVGCLF 240
Query: 241 FISWYSSFGFVRRWNCILMRNHDVTEQPMVLEKTASLMLKEAVSYIERHKHGPFLLFLSL 300
FISWYSSFGFVRRWNCILMRNHDVTEQPMVLEKTASLMLKEAVSYIERHKHGPFLLFLSL
Sbjct: 241 FISWYSSFGFVRRWNCILMRNHDVTEQPMVLEKTASLMLKEAVSYIERHKHGPFLLFLSL 300
Query: 301 LHVHIPLVTTSAFLGKSQHGLYGDNVEEMDWLIGKVLNAIEDNGLKNSTFTYFTSDHGGH 360
LHVHIPLVTTSAFLGKSQHGLYGDNVEEMDWLIGKVLNAIEDNGLKNSTFTYFTSDHGGH
Sbjct: 301 LHVHIPLVTTSAFLGKSQHGLYGDNVEEMDWLIGKVLNAIEDNGLKNSTFTYFTSDHGGH 360
Query: 361 LEARDGHSQLGGWNGIYKGGKGMGGWEGGIRVPGIFHWPGVLPAGRVIGEPTSLMDVFPT 420
LEARDGHSQLGGWNGIYKGGKGMGGWEGGIRVPGIFHWPGVLPAGRVIGEPTSLMDVFPT
Sbjct: 361 LEARDGHSQLGGWNGIYKGGKGMGGWEGGIRVPGIFHWPGVLPAGRVIGEPTSLMDVFPT 420
Query: 421 VVQLVGGEVPQDRVIDGHSLVPLLQGAEARSAHEFLFHYCGQHLHAARWHQKDSGSVWKV 480
VVQLVGGEVPQDRVIDGHSLVPLLQGAEARSAHEFLFHYCGQHLHAARWHQKDSGSVWKV
Sbjct: 421 VVQLVGGEVPQDRVIDGHSLVPLLQGAEARSAHEFLFHYCGQHLHAARWHQKDSGSVWKV 480
Query: 481 HYTTPQFHPEGAGACYGRGVCPCSGEGVTHHRPPLLFDLSRDPSEARPLTPDSEPLYHAV 540
HYTTPQFHPEGAGACYGRGVCPCSGEGVTHHRPPLLFDLSRDPSEARPLTPDSEPLYHAV
Sbjct: 481 HYTTPQFHPEGAGACYGRGVCPCSGEGVTHHRPPLLFDLSRDPSEARPLTPDSEPLYHAV 540
Query: 541 IARVGAAVSEHRQTLSPVPQQFSMSNILWKPWLQPCCGHFPFCSCHEDGDGTP 593
IARVGAAVSEHRQTLSPVPQQFSMSNILWKPWLQPCCGHFPFCSCHEDGDGTP
Sbjct: 541 IARVGAAVSEHRQTLSPVPQQFSMSNILWKPWLQPCCGHFPFCSCHEDGDGTP 593
>gi|58743319 arylsulfatase family, member H [Homo sapiens]
Length = 562
Score = 781 bits (2018), Expect = 0.0
Identities = 363/560 (64%), Positives = 436/560 (77%), Gaps = 3/560 (0%)
Query: 35 TANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGVRLTQHLAAAPLCTPSRA 94
T NA +PNI+L+MADDLG GDL CYGNN++ TPNID+LA EGVRLTQHLAAA +CTPSRA
Sbjct: 2 TRNA-RPNIVLLMADDLGVGDLCCYGNNSVSTPNIDRLASEGVRLTQHLAAASMCTPSRA 60
Query: 95 AFLTGRHSFRSGM-DASNGYRALQWNAGSGGLPENETTFARILQQHGYATGLIGKWHQGV 153
AFLTGR+ RSGM A N RA W GSGGLP NETTFA++LQ GY TGLIGKWH G+
Sbjct: 61 AFLTGRYPIRSGMVSAYNLNRAFTWLGGSGGLPTNETTFAKLLQHRGYRTGLIGKWHLGL 120
Query: 154 NCASRGDHCHHPLNHGFDYFYGMPFTLTNDCDPGRPPEVDAALRAQLWGYTQFLALGILT 213
+CASR DHC+HPLNHGF YFYG+PF L +DC + PE+ LR +LW T LAL
Sbjct: 121 SCASRNDHCYHPLNHGFHYFYGVPFGLLSDCQASKTPELHRWLRIKLWISTVALALVPFL 180
Query: 214 LAAGQTCGFFSVSARAVTGMAGVGCLFFISWYSSFGFVRRWNCILMRNHDVTEQPMVLEK 273
L + +FSV + + A + LFF SWYSS+GF RRWNCILMRNH++ +QPM EK
Sbjct: 181 LLIPKFARWFSVPWKVIFVFALLAFLFFTSWYSSYGFTRRWNCILMRNHEIIQQPMKEEK 240
Query: 274 TASLMLKEAVSYIERHKHGPFLLFLSLLHVHIPLVTTSAFLGKSQHGLYGDNVEEMDWLI 333
ASLMLKEA+++IER+K PFLLF S LHVH PL++ F+G+S++G YGDNVEEMDW++
Sbjct: 241 VASLMLKEALAFIERYKREPFLLFFSFLHVHTPLISKKKFVGRSKYGRYGDNVEEMDWMV 300
Query: 334 GKVLNAIEDNGLKNSTFTYFTSDHGGHLEARDGHSQLGGWNGIYKGGKGMGGWEGGIRVP 393
GK+L+A++ L N T YFTSD+GGHLE DG QLGGWNGIYKGGKGMGGWEGGIRVP
Sbjct: 301 GKILDALDQERLANHTLVYFTSDNGGHLEPLDGAVQLGGWNGIYKGGKGMGGWEGGIRVP 360
Query: 394 GIFHWPGVLPAGRVIGEPTSLMDVFPTVVQLVGGEVPQDRVIDGHSLVPLLQGAEARSAH 453
GIF WP VL AGRVI EPTSLMD++PT+ + GG + QDRVIDG +L+PLL+G + S H
Sbjct: 361 GIFRWPSVLEAGRVINEPTSLMDIYPTLSYIGGGILSQDRVIDGQNLMPLLEGRASHSDH 420
Query: 454 EFLFHYCGQHLHAARWHQKDSGSVWKVHYTTPQFHPEGAGACYGRGVCPCSGEGVTHHRP 513
EFLFHYCG +LH RWHQKD +VWK HY TP+F+PEG GACYG G+C CSG+ VT+H P
Sbjct: 421 EFLFHYCGVYLHTVRWHQKDCATVWKAHYVTPKFYPEGTGACYGSGICSCSGD-VTYHDP 479
Query: 514 PLLFDLSRDPSEARPLTPDSEPLYHAVIARVGAAVSEHRQTLSPVPQQFSMSNILWKPWL 573
PLLFD+SRDPSEA PL PD+EPL+ +VI ++ AA+ EHR+TL+PVPQQFS+ N +WKPWL
Sbjct: 480 PLLFDISRDPSEALPLNPDNEPLFDSVIKKMEAAIREHRRTLTPVPQQFSVFNTIWKPWL 539
Query: 574 QPCCGHFPFCSCHEDGDGTP 593
QPCCG FPFC C ++ D P
Sbjct: 540 QPCCGTFPFCGCDKEDDILP 559
>gi|157266309 arylsulfatase E precursor [Homo sapiens]
Length = 589
Score = 771 bits (1990), Expect = 0.0
Identities = 366/576 (63%), Positives = 428/576 (74%)
Query: 15 RDSLPVLLFLCLLLKTCEPKTANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAE 74
R LP +L + L L +A +PNILL+MADDLG GD+GCYGNNT+RTPNID+LAE
Sbjct: 12 RSWLPAMLAVLLSLAPSASSDISASRPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAE 71
Query: 75 EGVRLTQHLAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETTFAR 134
+GV+LTQH++AA LCTPSRAAFLTGR+ RSGM +S GYR LQW SGGLP NETTFA+
Sbjct: 72 DGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAK 131
Query: 135 ILQQHGYATGLIGKWHQGVNCASRGDHCHHPLNHGFDYFYGMPFTLTNDCDPGRPPEVDA 194
IL++ GYATGLIGKWH G+NC S DHCHHPL+HGFD+FYGMPF+L DC E
Sbjct: 132 ILKEKGYATGLIGKWHLGLNCESASDHCHHPLHHGFDHFYGMPFSLMGDCARWELSEKRV 191
Query: 195 ALRAQLWGYTQFLALGILTLAAGQTCGFFSVSARAVTGMAGVGCLFFISWYSSFGFVRRW 254
L +L Q LAL LTL AG+ VS V A L S Y +
Sbjct: 192 NLEQKLNFLFQVLALVALTLVAGKLTHLIPVSWMPVIWSALSAVLLLASSYFVGALIVHA 251
Query: 255 NCILMRNHDVTEQPMVLEKTASLMLKEAVSYIERHKHGPFLLFLSLLHVHIPLVTTSAFL 314
+C LMRNH +TEQPM ++T L+L+E S+++R+KHGPFLLF+S LHVHIPL+T FL
Sbjct: 252 DCFLMRNHTITEQPMCFQRTTPLILQEVASFLKRNKHGPFLLFVSFLHVHIPLITMENFL 311
Query: 315 GKSQHGLYGDNVEEMDWLIGKVLNAIEDNGLKNSTFTYFTSDHGGHLEARDGHSQLGGWN 374
GKS HGLYGDNVEEMDW++G++L+ ++ GL NST YFTSDHGG LE + G++Q GGWN
Sbjct: 312 GKSLHGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWN 371
Query: 375 GIYKGGKGMGGWEGGIRVPGIFHWPGVLPAGRVIGEPTSLMDVFPTVVQLVGGEVPQDRV 434
GIYKGGKGMGGWEGGIRVPGIF WPGVLPAGRVIGEPTSLMDVFPTVV+L GGEVPQDRV
Sbjct: 372 GIYKGGKGMGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRV 431
Query: 435 IDGHSLVPLLQGAEARSAHEFLFHYCGQHLHAARWHQKDSGSVWKVHYTTPQFHPEGAGA 494
IDG L+PLL G S HEFL HYC + LHAARWHQ+D G++WKVH+ TP F PEGAGA
Sbjct: 432 IDGQDLLPLLLGTAQHSDHEFLMHYCERFLHAARWHQRDRGTMWKVHFVTPVFQPEGAGA 491
Query: 495 CYGRGVCPCSGEGVTHHRPPLLFDLSRDPSEARPLTPDSEPLYHAVIARVGAAVSEHRQT 554
CYGR VCPC GE V HH PPLLFDLSRDPSE LTP SEP+++ V+ RV AV EH++T
Sbjct: 492 CYGRKVCPCFGEKVVHHDPPLLFDLSRDPSETHILTPASEPVFYQVMERVQQAVWEHQRT 551
Query: 555 LSPVPQQFSMSNILWKPWLQPCCGHFPFCSCHEDGD 590
LSPVP Q +W+PWLQPCCG FP C C + D
Sbjct: 552 LSPVPLQLDRLGNIWRPWLQPCCGPFPLCWCLREDD 587
>gi|31742482 arylsulfatase F precursor [Homo sapiens]
Length = 590
Score = 723 bits (1867), Expect = 0.0
Identities = 343/575 (59%), Positives = 417/575 (72%), Gaps = 2/575 (0%)
Query: 15 RDSLPVLLFLCLLLKTCEPKTANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAE 74
R L + +C LL TC+ + KPNI+LIM DDLG GDLGCYGN+T+RTP+ID+LA
Sbjct: 4 RRPLVFMSLVCALLNTCQAHRVHDDKPNIVLIMVDDLGIGDLGCYGNDTMRTPHIDRLAR 63
Query: 75 EGVRLTQHLAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETTFAR 134
EGVRLTQH++AA LC+PSR+AFLTGR+ RSGM +S R +Q A GLP NETT A
Sbjct: 64 EGVRLTQHISAASLCSPSRSAFLTGRYPIRSGMVSSGNRRVIQNLAVPAGLPLNETTLAA 123
Query: 135 ILQQHGYATGLIGKWHQGVNCASRGDHCHHPLNHGFDYFYGMPFTLTNDCDPGRPPEVDA 194
+L++ GY+TGLIGKWHQG+NC SR D CHHP N+GFDY+YGMPFTL + C P +
Sbjct: 124 LLKKQGYSTGLIGKWHQGLNCDSRSDQCHHPYNYGFDYYYGMPFTLVDSCWPDPSRNTEL 183
Query: 195 ALRAQLWGYTQFLALGILTLAAGQTCGFFSVSARAVTGMAGVGCLFFISWYSSFGFVRRW 254
A +QLW Q +A+ ILTL G+ G+ SV + M L +W+SS W
Sbjct: 184 AFESQLWLCVQLVAIAILTLTFGKLSGWVSVPWLLIFSMILFIFLLGYAWFSSHTSPLYW 243
Query: 255 NCILMRNHDVTEQPMVLEKTASLMLKEAVSYIERHKHGPFLLFLSLLHVHIPLVTTSAFL 314
+C+LMR H++TEQPM E+ S+M+KEA+S++ERH FLLF S LHVH PL TT F
Sbjct: 244 DCLLMRGHEITEQPMKAERAGSIMVKEAISFLERHSKETFLLFFSFLHVHTPLPTTDDFT 303
Query: 315 GKSQHGLYGDNVEEMDWLIGKVLNAIEDNGLKNSTFTYFTSDHGGHLEARDGHSQLGGWN 374
G S+HGLYGDNVEEMD ++GK+L+AI+D GL+N+T YFTSDHGGHLEAR GH+QLGGWN
Sbjct: 304 GTSKHGLYGDNVEEMDSMVGKILDAIDDFGLRNNTLVYFTSDHGGHLEARRGHAQLGGWN 363
Query: 375 GIYKGGKGMGGWEGGIRVPGIFHWPGVLPAGRVIGEPTSLMDVFPTVVQLVGGEVPQDRV 434
GIYKGGKGMGGWEGGIRVPGI WPG +PAGR+I EPTSLMD+ PTV + GG +PQDRV
Sbjct: 364 GIYKGGKGMGGWEGGIRVPGIVRWPGKVPAGRLIKEPTSLMDILPTVASVSGGSLPQDRV 423
Query: 435 IDGHSLVPLLQGAEARSAHEFLFHYCGQHLHAARWHQK-DSGSVWKVHYTTPQFHPEGAG 493
IDG L+PLLQG S HEFLFHYCG +LHA RW K DSGSVWK HY TP F P +G
Sbjct: 424 IDGRDLMPLLQGNVRHSEHEFLFHYCGSYLHAVRWIPKDDSGSVWKAHYVTPVFQPPASG 483
Query: 494 ACYGRGVCPCSGEGVTHHRPPLLFDLSRDPSEARPLTPDSEPLYHAVIARVGAAVSEHRQ 553
CY +C C GE VT+H PPLLFDLSRDPSE+ PLTP +EPL+ VI +V A+ EH++
Sbjct: 484 GCYVTSLCRCFGEQVTYHNPPLLFDLSRDPSESTPLTPATEPLHDFVIKKVANALKEHQE 543
Query: 554 TLSPVPQQFSMSNILWKPWLQPCCGHFPFCSCHED 588
T+ PV Q S N + WL+PCCG FPFC C ++
Sbjct: 544 TIVPVTYQLSELN-QGRTWLKPCCGVFPFCLCDKE 577
>gi|71852586 arylsulfatase D isoform b precursor [Homo sapiens]
Length = 382
Score = 694 bits (1792), Expect = 0.0
Identities = 333/333 (100%), Positives = 333/333 (100%)
Query: 1 MRSAARRGRAAPAARDSLPVLLFLCLLLKTCEPKTANAFKPNILLIMADDLGTGDLGCYG 60
MRSAARRGRAAPAARDSLPVLLFLCLLLKTCEPKTANAFKPNILLIMADDLGTGDLGCYG
Sbjct: 1 MRSAARRGRAAPAARDSLPVLLFLCLLLKTCEPKTANAFKPNILLIMADDLGTGDLGCYG 60
Query: 61 NNTLRTPNIDQLAEEGVRLTQHLAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWNA 120
NNTLRTPNIDQLAEEGVRLTQHLAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWNA
Sbjct: 61 NNTLRTPNIDQLAEEGVRLTQHLAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWNA 120
Query: 121 GSGGLPENETTFARILQQHGYATGLIGKWHQGVNCASRGDHCHHPLNHGFDYFYGMPFTL 180
GSGGLPENETTFARILQQHGYATGLIGKWHQGVNCASRGDHCHHPLNHGFDYFYGMPFTL
Sbjct: 121 GSGGLPENETTFARILQQHGYATGLIGKWHQGVNCASRGDHCHHPLNHGFDYFYGMPFTL 180
Query: 181 TNDCDPGRPPEVDAALRAQLWGYTQFLALGILTLAAGQTCGFFSVSARAVTGMAGVGCLF 240
TNDCDPGRPPEVDAALRAQLWGYTQFLALGILTLAAGQTCGFFSVSARAVTGMAGVGCLF
Sbjct: 181 TNDCDPGRPPEVDAALRAQLWGYTQFLALGILTLAAGQTCGFFSVSARAVTGMAGVGCLF 240
Query: 241 FISWYSSFGFVRRWNCILMRNHDVTEQPMVLEKTASLMLKEAVSYIERHKHGPFLLFLSL 300
FISWYSSFGFVRRWNCILMRNHDVTEQPMVLEKTASLMLKEAVSYIERHKHGPFLLFLSL
Sbjct: 241 FISWYSSFGFVRRWNCILMRNHDVTEQPMVLEKTASLMLKEAVSYIERHKHGPFLLFLSL 300
Query: 301 LHVHIPLVTTSAFLGKSQHGLYGDNVEEMDWLI 333
LHVHIPLVTTSAFLGKSQHGLYGDNVEEMDWLI
Sbjct: 301 LHVHIPLVTTSAFLGKSQHGLYGDNVEEMDWLI 333
>gi|53831991 steryl-sulfatase precursor [Homo sapiens]
Length = 583
Score = 587 bits (1512), Expect = e-167
Identities = 282/567 (49%), Positives = 367/567 (64%), Gaps = 6/567 (1%)
Query: 12 PAARDSLPVLLFLCLLLKTCEPKTANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQ 71
P + +P LL L E ++ A +PNI+L+MADDLG GD GCYGN T+RTPNID+
Sbjct: 2 PLRKMKIPFLLLFFLW----EAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDR 57
Query: 72 LAEEGVRLTQHLAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETT 131
LA GV+LTQHLAA+PLCTPSRAAF+TGR+ RSGM + + + A SGGLP +E T
Sbjct: 58 LASGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEIT 117
Query: 132 FARILQQHGYATGLIGKWHQGVNCASRGDHCHHPLNHGFDYFYGMPFTLTNDCDPGRPPE 191
FA++L+ GY+T LIGKWH G++C S+ D CHHPL+HGF+YFYG+ T DC PG
Sbjct: 118 FAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSV 177
Query: 192 VDAALRAQLWGYTQFLALGILTLAAGQTCGFFSVSARAVTGMAGVGCLFFISWYSSFGFV 251
+ ++ Q + + +LTLAA G V + + L + +
Sbjct: 178 FTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYF 237
Query: 252 RRWNCILMRNHDVTEQPMVLEKTASLMLKEAVSYIERHKHGPFLLFLSLLHVHIPLVTTS 311
R NC +MRN+++ +QPM + + EA +I+R+ PFLL LS LHVH L ++
Sbjct: 238 RPLNCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSK 297
Query: 312 AFLGKSQHGLYGDNVEEMDWLIGKVLNAIEDNGLKNSTFTYFTSDHGGHLEARDGHSQL- 370
F GKSQHG+YGD VEEMDW +G++LN +++ L N T YFTSD G H+E ++
Sbjct: 298 DFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIH 357
Query: 371 GGWNGIYKGGKGMGGWEGGIRVPGIFHWPGVLPAGRVIGEPTSLMDVFPTVVQLVGGEVP 430
GG NGIYKGGK WEGGIRVPGI WP V+ AG+ I EPTS MD+FPTV +L G +P
Sbjct: 358 GGSNGIYKGGKA-NNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLP 416
Query: 431 QDRVIDGHSLVPLLQGAEARSAHEFLFHYCGQHLHAARWHQKDSGSVWKVHYTTPQFHPE 490
+DR+IDG L+PLL+G RS HEFLFHYC +L+A RWH ++S S+WK + TP F+P
Sbjct: 417 EDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPV 476
Query: 491 GAGACYGRGVCPCSGEGVTHHRPPLLFDLSRDPSEARPLTPDSEPLYHAVIARVGAAVSE 550
G+ C+ VC C G VTHH PPLLFD+S+DP E PLTP SEP ++ ++ + A
Sbjct: 477 GSNGCFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADR 536
Query: 551 HRQTLSPVPQQFSMSNILWKPWLQPCC 577
H QTL VP QFS +N LWKPWLQ CC
Sbjct: 537 HTQTLPEVPDQFSWNNFLWKPWLQLCC 563
>gi|4503899 galactosamine (N-acetyl)-6-sulfate sulfatase precursor
[Homo sapiens]
Length = 522
Score = 245 bits (626), Expect = 7e-65
Identities = 174/547 (31%), Positives = 261/547 (47%), Gaps = 74/547 (13%)
Query: 41 PNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGVRLTQHLAAAPLCTPSRAAFLTGR 100
PNILL++ DD+G GDLG YG + TPN+D++A EG+ +A PLC+PSRAA LTGR
Sbjct: 31 PNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLTGR 90
Query: 101 HSFRSGMDASNGYRALQWNAGS--GGLPENETTFARILQQHGYATGLIGKWHQGVNCASR 158
R+G +N + + GG+P++E +L++ GY + ++GKWH G
Sbjct: 91 LPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRPQ-- 148
Query: 159 GDHCHHPLNHGFDYFYGMPFTLTNDCDPGRPPEVDAALRAQLWGYTQFLALGILTLAAGQ 218
HPL HGFD ++G P +C G D R + Y + +G
Sbjct: 149 ----FHPLKHGFDEWFGSP-----NCHFG---PYDNKARPNIPVYRDWEMVG-------- 188
Query: 219 TCGFFSVSARAVTGMAGVGCLFFISWYSSFGFVRRWNCILMRNHDVTEQPMVLEKTASLM 278
+Y F I ++ + + L++ +
Sbjct: 189 ------------------------RYYEEFP-------INLKTGEANLTQIYLQEALDFI 217
Query: 279 LKEAVSYIERHKHGPFLLFLSLLHVHIPLVTTSAFLGKSQHGLYGDNVEEMDWLIGKVLN 338
++A +H PF L+ ++ H P+ + FLG SQ G YGD V E+D IGK+L
Sbjct: 218 KRQA-------RHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDDSIGKILE 270
Query: 339 AIEDNGLKNSTFTYFTSDHGGHLEARDGHSQLGGWNGIYKGGKGMGGWEGGIRVPGIFHW 398
++D + ++TF +FTSD+G L + + GG NG + GK +EGG+R P + W
Sbjct: 271 LLQDLHVADNTFVFFTSDNGAALISA---PEQGGSNGPFLCGK-QTTFEGGMREPALAWW 326
Query: 399 PGVLPAGRVIGEPTSLMDVFPTVVQLVGGEVPQDRVIDGHSLVP-LLQGAEARSAHEFLF 457
PG + AG+V + S+MD+F T + L G P DR IDG +L+P LLQG R +F
Sbjct: 327 PGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQG---RLMDRPIF 383
Query: 458 HYCGQHLHAARWHQKDSGSVWKVHYTTPQFHPEGAGACYGRGVCPCSGEGVTHH-RPPLL 516
+Y G L AA Q W + F +G C G+ V + + H + PL+
Sbjct: 384 YYRGDTLMAATLGQ-HKAHFWTWTNSWENFR-QGIDFCPGQNVSGVTTHNLEDHTKLPLI 441
Query: 517 FDLSRDPSEARPLTPDSEPLYHAVIARVGAAVSEHRQTLSPVPQQFSMSNILWKPWLQPC 576
F L RDP E PL+ S Y ++R+ + V +H++ L P Q ++ N W P
Sbjct: 442 FHLGRDPGERFPLSFASAE-YQEALSRITSVVQQHQEALVPAQPQLNVCNWAVMNWAPPG 500
Query: 577 CGHFPFC 583
C C
Sbjct: 501 CEKLGKC 507
>gi|45430057 Arylsulfatase G [Homo sapiens]
Length = 525
Score = 136 bits (342), Expect = 6e-32
Identities = 101/336 (30%), Positives = 157/336 (46%), Gaps = 24/336 (7%)
Query: 258 LMRNHDVTEQPMVLEKTASLMLKEAVSYIERHKHG--PFLLFLSLLHVHIPLVTTSAFLG 315
L N ++ EQP+ L A ++A +I+R PFLL+++L H+H+PL T
Sbjct: 203 LYENLNIVEQPVNLSSLAQKYAEKATQFIQRASTSGRPFLLYVALAHMHVPLPVTQLPAA 262
Query: 316 KSQHGLYGDNVEEMDWLIGKVLNAIEDNGLKNSTFTYFTSDHGGHLEARDGHSQLGGWNG 375
LYG + EMD L+G++ + + D+ +K +TF +FT D+G + + +G + G
Sbjct: 263 PRGRSLYGAGLWEMDSLVGQIKDKV-DHTVKENTFLWFTGDNGPWAQKCELAGSVGPFTG 321
Query: 376 IYKGGKG-----MGGWEGGIRVPGIFHWPGVLPAGRVIGEPTSLMDVFPTVVQLVGGEVP 430
++ +G WEGG RVP + +WPG +P S++D+FPTVV L +P
Sbjct: 322 FWQTRQGGSPAKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAQASLP 381
Query: 431 QDRVIDGHSLVPLLQGAEARSAHEFLFHYCGQHLHAARWHQKDSGSVWKVHYTTPQFHPE 490
Q R DG + +L G ++ H LFH Q +K Y T
Sbjct: 382 QGRRFDGVDVSEVLFG-RSQPGHRVLFHPNSGAAGEFGALQTVRLERYKAFYIT-----G 435
Query: 491 GAGACYGRGVCPCSGEGVTHHRPPLLFDLSRDPSEARPLTPDSEPLYHAVIARVGAAVSE 550
GA AC G S H+ PL+F+L D +EA PL Y AV+ V +++
Sbjct: 436 GARACDG------STGPELQHKFPLIFNLEDDTAEAVPLERGGAE-YQAVLPEVRKVLAD 488
Query: 551 HRQTLSPVPQQFSMSNILWKPWLQPCCGHFPF-CSC 585
Q ++ S ++ P + PCC + C C
Sbjct: 489 VLQDIA--NDNISSADYTQDPSVTPCCNPYQIACRC 522
Score = 129 bits (325), Expect = 6e-30
Identities = 69/162 (42%), Positives = 95/162 (58%), Gaps = 12/162 (7%)
Query: 23 FLCLLLKTCEPKTANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGVRLTQH 82
FL L+ C KPN ++I+ADD+G GDLG T T N+D++A EG+R
Sbjct: 18 FLYPLVDFCISGKTRGQKPNFVIILADDMGWGDLGANWAETKDTANLDKMASEGMRFVDF 77
Query: 83 LAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETTFARILQQHGYA 142
AAA C+PSRA+ LTGR R+G+ + ++ GGLP NETT A +LQQ GY
Sbjct: 78 HAAASTCSPSRASLLTGRLGLRNGVTRNFAVTSV------GGLPLNETTLAEVLQQAGYV 131
Query: 143 TGLIGKWHQGVNCASRGDHCHHPLNHGFDYFYGMPFTLTNDC 184
TG+IGKWH G + + +HP GFDY++G+P++ C
Sbjct: 132 TGIIGKWHLGHHGS------YHPNFRGFDYYFGIPYSHDMGC 167
>gi|38569407 arylsulfatase B isoform 2 precursor [Homo sapiens]
Length = 413
Score = 129 bits (323), Expect = 1e-29
Identities = 128/448 (28%), Positives = 190/448 (42%), Gaps = 90/448 (20%)
Query: 2 RSAARRGRAAPAARDSLPVLLFLCLLLKTCEPKT-ANAFKP-NILLIMADDLGTGDLGCY 59
R AA R R LPV+L L LLL P + A A +P +++ ++ADDLG D+G +
Sbjct: 4 RGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFH 63
Query: 60 GNNTLRTPNIDQLAEEGVRLTQHLAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWN 119
G+ +RTP++D LA GV L + PLCTPSR+ LTGR+ R+G+ + W
Sbjct: 64 GSR-IRTPHLDALAAGGVLLDNYYTQ-PLCTPSRSQLLTGRYQIRTGLQ-----HQIIWP 116
Query: 120 AGSGGLPENETTFARILQQHGYATGLIGKWHQGV---NCASRGDHCHHPLNHGFDYFYGM 176
+P +E ++L++ GY T ++GKWH G+ C P GFD ++G
Sbjct: 117 CQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECL--------PTRRGFDTYFGY 168
Query: 177 PFTLTNDCDPGRPPEVDAALRAQLWGYTQFLALGILTLAAGQTCGFFSVSARAVTGMAGV 236
+ R +D AL + A F TG
Sbjct: 169 LLGSEDYYSHERCTLID--------------ALNVTRCALD-----FRDGEEVATG---- 205
Query: 237 GCLFFISWYSSFGFVRRWNCILMRNHDVTEQPMVLEKTASLMLKEAVSYIERHKHGPFLL 296
+ + YS+ F +R L+ NH E+P+ L
Sbjct: 206 ----YKNMYSTNIFTKR-AIALITNHP-PEKPL-------------------------FL 234
Query: 297 FLSLLHVHIPLVTTSAFL-------GKSQHGLYGDNVEEMDWLIGKVLNAIEDNGLKNST 349
+L+L VH PL +L K++H Y V MD +G V A++ +GL N+T
Sbjct: 235 YLALQSVHEPLQVPEEYLKPYDFIQDKNRHH-YAGMVSLMDEAVGNVTAALKSSGLWNNT 293
Query: 350 FTYFTSDHGGHLEARDGHSQLGGWNGIYKGGKGMGGWEGGIRVPGIFHWPGVLPAGRVIG 409
F++D+GG L G N G+ WEGG+R G P + G
Sbjct: 294 VFIFSTDNGG--------QTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNR 345
Query: 410 EPTSLMDVFPTVVQLVGGEVPQDRVIDG 437
E + D PT+V+L G + +DG
Sbjct: 346 ELIHISDWLPTLVKLARGHTNGTKPLDG 373
>gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens]
Length = 533
Score = 129 bits (323), Expect = 1e-29
Identities = 128/448 (28%), Positives = 190/448 (42%), Gaps = 90/448 (20%)
Query: 2 RSAARRGRAAPAARDSLPVLLFLCLLLKTCEPKT-ANAFKP-NILLIMADDLGTGDLGCY 59
R AA R R LPV+L L LLL P + A A +P +++ ++ADDLG D+G +
Sbjct: 4 RGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFH 63
Query: 60 GNNTLRTPNIDQLAEEGVRLTQHLAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWN 119
G+ +RTP++D LA GV L + PLCTPSR+ LTGR+ R+G+ + W
Sbjct: 64 GSR-IRTPHLDALAAGGVLLDNYYTQ-PLCTPSRSQLLTGRYQIRTGLQ-----HQIIWP 116
Query: 120 AGSGGLPENETTFARILQQHGYATGLIGKWHQGV---NCASRGDHCHHPLNHGFDYFYGM 176
+P +E ++L++ GY T ++GKWH G+ C P GFD ++G
Sbjct: 117 CQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECL--------PTRRGFDTYFGY 168
Query: 177 PFTLTNDCDPGRPPEVDAALRAQLWGYTQFLALGILTLAAGQTCGFFSVSARAVTGMAGV 236
+ R +D AL + A F TG
Sbjct: 169 LLGSEDYYSHERCTLID--------------ALNVTRCALD-----FRDGEEVATG---- 205
Query: 237 GCLFFISWYSSFGFVRRWNCILMRNHDVTEQPMVLEKTASLMLKEAVSYIERHKHGPFLL 296
+ + YS+ F +R L+ NH E+P+ L
Sbjct: 206 ----YKNMYSTNIFTKR-AIALITNHP-PEKPL-------------------------FL 234
Query: 297 FLSLLHVHIPLVTTSAFL-------GKSQHGLYGDNVEEMDWLIGKVLNAIEDNGLKNST 349
+L+L VH PL +L K++H Y V MD +G V A++ +GL N+T
Sbjct: 235 YLALQSVHEPLQVPEEYLKPYDFIQDKNRHH-YAGMVSLMDEAVGNVTAALKSSGLWNNT 293
Query: 350 FTYFTSDHGGHLEARDGHSQLGGWNGIYKGGKGMGGWEGGIRVPGIFHWPGVLPAGRVIG 409
F++D+GG L G N G+ WEGG+R G P + G
Sbjct: 294 VFIFSTDNGG--------QTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNR 345
Query: 410 EPTSLMDVFPTVVQLVGGEVPQDRVIDG 437
E + D PT+V+L G + +DG
Sbjct: 346 ELIHISDWLPTLVKLARGHTNGTKPLDG 373
>gi|146229331 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 124 bits (312), Expect = 2e-28
Identities = 69/144 (47%), Positives = 83/144 (57%), Gaps = 9/144 (6%)
Query: 36 ANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGVRLTQHLAAAPLCTPSRAA 95
A A PNI+LI ADDLG GDLGCYG+ + TPN+DQLA G+R T LCTPSRAA
Sbjct: 16 AVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAA 75
Query: 96 FLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETTFARILQQHGYATGLIGKWHQGVNC 155
LTGR R GM Y + + GGLP E T A +L GY TG+ GKWH GV
Sbjct: 76 LLTGRLPVRMGM-----YPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVG- 129
Query: 156 ASRGDHCHHPLNHGFDYFYGMPFT 179
+ P + GF F G+P++
Sbjct: 130 ---PEGAFLPPHQGFHRFLGIPYS 150
Score = 112 bits (281), Expect = 7e-25
Identities = 76/235 (32%), Positives = 113/235 (48%), Gaps = 17/235 (7%)
Query: 293 PFLLFLSLLHVHIPLVTTSAFLGKSQHGLYGDNVEEMDWLIGKVLNAIEDNGLKNSTFTY 352
PF L+ + H H P + +F +S G +GD++ E+D +G ++ AI D GL T
Sbjct: 218 PFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVI 277
Query: 353 FTSDHGGHLEARDGHSQLGGWNGIYKGGKGMGGWEGGIRVPGIFHWPGVLPAGRVIGEPT 412
FT+D+G GG +G+ + GKG +EGG+R P + WPG + G V E
Sbjct: 278 FTADNG----PETMRMSRGGCSGLLRCGKGT-TYEGGVREPALAFWPGHIAPG-VTHELA 331
Query: 413 SLMDVFPTVVQLVGGEVPQDRVIDGHSLVPLLQGAEARSAHEFLFHYCGQHLHAARWHQK 472
S +D+ PT+ L G +P + +DG L PLL G +S + LF Y
Sbjct: 332 SSLDLLPTLAALAGAPLP-NVTLDGFDLSPLLLGT-GKSPRQSLFFYPSYPDEVRGVFAV 389
Query: 473 DSGSVWKVHYTTPQFHPEGAG--ACYGRGVCPCSGEGVTHHRPPLLFDLSRDPSE 525
+G +T H + AC+ + +T H PPLL+DLS+DP E
Sbjct: 390 RTGKYKAHFFTQGSAHSDTTADPACH-------ASSSLTAHEPPLLYDLSKDPGE 437
>gi|146229329 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 124 bits (312), Expect = 2e-28
Identities = 69/144 (47%), Positives = 83/144 (57%), Gaps = 9/144 (6%)
Query: 36 ANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGVRLTQHLAAAPLCTPSRAA 95
A A PNI+LI ADDLG GDLGCYG+ + TPN+DQLA G+R T LCTPSRAA
Sbjct: 16 AVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAA 75
Query: 96 FLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETTFARILQQHGYATGLIGKWHQGVNC 155
LTGR R GM Y + + GGLP E T A +L GY TG+ GKWH GV
Sbjct: 76 LLTGRLPVRMGM-----YPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVG- 129
Query: 156 ASRGDHCHHPLNHGFDYFYGMPFT 179
+ P + GF F G+P++
Sbjct: 130 ---PEGAFLPPHQGFHRFLGIPYS 150
Score = 112 bits (281), Expect = 7e-25
Identities = 76/235 (32%), Positives = 113/235 (48%), Gaps = 17/235 (7%)
Query: 293 PFLLFLSLLHVHIPLVTTSAFLGKSQHGLYGDNVEEMDWLIGKVLNAIEDNGLKNSTFTY 352
PF L+ + H H P + +F +S G +GD++ E+D +G ++ AI D GL T
Sbjct: 218 PFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVI 277
Query: 353 FTSDHGGHLEARDGHSQLGGWNGIYKGGKGMGGWEGGIRVPGIFHWPGVLPAGRVIGEPT 412
FT+D+G GG +G+ + GKG +EGG+R P + WPG + G V E
Sbjct: 278 FTADNG----PETMRMSRGGCSGLLRCGKGT-TYEGGVREPALAFWPGHIAPG-VTHELA 331
Query: 413 SLMDVFPTVVQLVGGEVPQDRVIDGHSLVPLLQGAEARSAHEFLFHYCGQHLHAARWHQK 472
S +D+ PT+ L G +P + +DG L PLL G +S + LF Y
Sbjct: 332 SSLDLLPTLAALAGAPLP-NVTLDGFDLSPLLLGT-GKSPRQSLFFYPSYPDEVRGVFAV 389
Query: 473 DSGSVWKVHYTTPQFHPEGAG--ACYGRGVCPCSGEGVTHHRPPLLFDLSRDPSE 525
+G +T H + AC+ + +T H PPLL+DLS+DP E
Sbjct: 390 RTGKYKAHFFTQGSAHSDTTADPACH-------ASSSLTAHEPPLLYDLSKDPGE 437
>gi|146229324 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 124 bits (312), Expect = 2e-28
Identities = 69/144 (47%), Positives = 83/144 (57%), Gaps = 9/144 (6%)
Query: 36 ANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGVRLTQHLAAAPLCTPSRAA 95
A A PNI+LI ADDLG GDLGCYG+ + TPN+DQLA G+R T LCTPSRAA
Sbjct: 16 AVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAA 75
Query: 96 FLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETTFARILQQHGYATGLIGKWHQGVNC 155
LTGR R GM Y + + GGLP E T A +L GY TG+ GKWH GV
Sbjct: 76 LLTGRLPVRMGM-----YPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVG- 129
Query: 156 ASRGDHCHHPLNHGFDYFYGMPFT 179
+ P + GF F G+P++
Sbjct: 130 ---PEGAFLPPHQGFHRFLGIPYS 150
Score = 112 bits (281), Expect = 7e-25
Identities = 76/235 (32%), Positives = 113/235 (48%), Gaps = 17/235 (7%)
Query: 293 PFLLFLSLLHVHIPLVTTSAFLGKSQHGLYGDNVEEMDWLIGKVLNAIEDNGLKNSTFTY 352
PF L+ + H H P + +F +S G +GD++ E+D +G ++ AI D GL T
Sbjct: 218 PFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVI 277
Query: 353 FTSDHGGHLEARDGHSQLGGWNGIYKGGKGMGGWEGGIRVPGIFHWPGVLPAGRVIGEPT 412
FT+D+G GG +G+ + GKG +EGG+R P + WPG + G V E
Sbjct: 278 FTADNG----PETMRMSRGGCSGLLRCGKGT-TYEGGVREPALAFWPGHIAPG-VTHELA 331
Query: 413 SLMDVFPTVVQLVGGEVPQDRVIDGHSLVPLLQGAEARSAHEFLFHYCGQHLHAARWHQK 472
S +D+ PT+ L G +P + +DG L PLL G +S + LF Y
Sbjct: 332 SSLDLLPTLAALAGAPLP-NVTLDGFDLSPLLLGT-GKSPRQSLFFYPSYPDEVRGVFAV 389
Query: 473 DSGSVWKVHYTTPQFHPEGAG--ACYGRGVCPCSGEGVTHHRPPLLFDLSRDPSE 525
+G +T H + AC+ + +T H PPLL+DLS+DP E
Sbjct: 390 RTGKYKAHFFTQGSAHSDTTADPACH-------ASSSLTAHEPPLLYDLSKDPGE 437
>gi|6005990 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 124 bits (312), Expect = 2e-28
Identities = 69/144 (47%), Positives = 83/144 (57%), Gaps = 9/144 (6%)
Query: 36 ANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGVRLTQHLAAAPLCTPSRAA 95
A A PNI+LI ADDLG GDLGCYG+ + TPN+DQLA G+R T LCTPSRAA
Sbjct: 16 AVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAA 75
Query: 96 FLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETTFARILQQHGYATGLIGKWHQGVNC 155
LTGR R GM Y + + GGLP E T A +L GY TG+ GKWH GV
Sbjct: 76 LLTGRLPVRMGM-----YPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVG- 129
Query: 156 ASRGDHCHHPLNHGFDYFYGMPFT 179
+ P + GF F G+P++
Sbjct: 130 ---PEGAFLPPHQGFHRFLGIPYS 150
Score = 112 bits (281), Expect = 7e-25
Identities = 76/235 (32%), Positives = 113/235 (48%), Gaps = 17/235 (7%)
Query: 293 PFLLFLSLLHVHIPLVTTSAFLGKSQHGLYGDNVEEMDWLIGKVLNAIEDNGLKNSTFTY 352
PF L+ + H H P + +F +S G +GD++ E+D +G ++ AI D GL T
Sbjct: 218 PFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVI 277
Query: 353 FTSDHGGHLEARDGHSQLGGWNGIYKGGKGMGGWEGGIRVPGIFHWPGVLPAGRVIGEPT 412
FT+D+G GG +G+ + GKG +EGG+R P + WPG + G V E
Sbjct: 278 FTADNG----PETMRMSRGGCSGLLRCGKGT-TYEGGVREPALAFWPGHIAPG-VTHELA 331
Query: 413 SLMDVFPTVVQLVGGEVPQDRVIDGHSLVPLLQGAEARSAHEFLFHYCGQHLHAARWHQK 472
S +D+ PT+ L G +P + +DG L PLL G +S + LF Y
Sbjct: 332 SSLDLLPTLAALAGAPLP-NVTLDGFDLSPLLLGT-GKSPRQSLFFYPSYPDEVRGVFAV 389
Query: 473 DSGSVWKVHYTTPQFHPEGAG--ACYGRGVCPCSGEGVTHHRPPLLFDLSRDPSE 525
+G +T H + AC+ + +T H PPLL+DLS+DP E
Sbjct: 390 RTGKYKAHFFTQGSAHSDTTADPACH-------ASSSLTAHEPPLLYDLSKDPGE 437
>gi|59797060 arylsulfatase family, member I [Homo sapiens]
Length = 569
Score = 120 bits (302), Expect = 3e-27
Identities = 120/457 (26%), Positives = 188/457 (41%), Gaps = 93/457 (20%)
Query: 32 EPKTANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGVRLTQHLAAAPLCTP 91
+P A P+I+ I+ DD G D+G +G++ + TP +D+LA +GV+L + P+CTP
Sbjct: 38 QPSAAPPQPPHIIFILTDDQGYHDVGYHGSD-IETPTLDRLAAKGVKLENYYIQ-PICTP 95
Query: 92 SRAAFLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETTFARILQQHGYATGLIGKWHQ 151
SR+ LTGR+ +G+ S R Q N LP ++ T + LQ+ GY+T ++GKWH
Sbjct: 96 SRSQLLTGRYQIHTGLQHSI-IRPQQPNC----LPLDQVTLPQKLQEAGYSTHMVGKWHL 150
Query: 152 GV---NCASRGDHCHHPLNHGFDYFYGMPFTLTNDCDPGRPPEVDAALRAQLWGYTQFLA 208
G C P GFD F G +LT + D + Y
Sbjct: 151 GFYRKECL--------PTRRGFDTFLG---SLTGNVD--------------YYTYDNCDG 185
Query: 209 LGILTLAAGQTCGF-FSVSARAVTGMAGVGCLFFISWYSSFGFVRRWNCILMRNHDVTEQ 267
G+ CGF G++G YS+ + +R + IL + ++
Sbjct: 186 PGV--------CGFDLHEGENVAWGLSG--------QYSTMLYAQRASHILASHS--PQR 227
Query: 268 PMVLEKTASLMLKEAVSYIERHKHGPFLLFLSLLHVHIPLVTTSAFL------GKSQHGL 321
P+ L+++ VH PL + +L G
Sbjct: 228 PL-------------------------FLYVAFQAVHTPLQSPREYLYRYRTMGNVARRK 262
Query: 322 YGDNVEEMDWLIGKVLNAIEDNGLKNSTFTYFTSDHGGHLEARDGHSQLGGWNGIYKGGK 381
Y V MD + + A++ G N++ F+SD+GG + GG N +G K
Sbjct: 263 YAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQTFS-------GGSNWPLRGRK 315
Query: 382 GMGGWEGGIRVPGIFHWPGVLPAGRVIGEPTSLMDVFPTVVQLVGGEVPQDRVIDGHSLV 441
G WEGG+R G H P + R + D +PT+V L GG +DG+ +
Sbjct: 316 GT-YWEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAGGTTSAADGLDGYDVW 374
Query: 442 PLLQGAEARSAHEFLFHYCGQHLHAARWHQKDSGSVW 478
P + A E L + + HA + +W
Sbjct: 375 PAISEGRASPRTEILHNIDPLYNHAQHGSLEGGFGIW 411
>gi|146229327 arylsulfatase A isoform b [Homo sapiens]
Length = 423
Score = 112 bits (281), Expect = 7e-25
Identities = 76/235 (32%), Positives = 113/235 (48%), Gaps = 17/235 (7%)
Query: 293 PFLLFLSLLHVHIPLVTTSAFLGKSQHGLYGDNVEEMDWLIGKVLNAIEDNGLKNSTFTY 352
PF L+ + H H P + +F +S G +GD++ E+D +G ++ AI D GL T
Sbjct: 134 PFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVI 193
Query: 353 FTSDHGGHLEARDGHSQLGGWNGIYKGGKGMGGWEGGIRVPGIFHWPGVLPAGRVIGEPT 412
FT+D+G GG +G+ + GKG +EGG+R P + WPG + G V E
Sbjct: 194 FTADNG----PETMRMSRGGCSGLLRCGKGT-TYEGGVREPALAFWPGHIAPG-VTHELA 247
Query: 413 SLMDVFPTVVQLVGGEVPQDRVIDGHSLVPLLQGAEARSAHEFLFHYCGQHLHAARWHQK 472
S +D+ PT+ L G +P + +DG L PLL G +S + LF Y
Sbjct: 248 SSLDLLPTLAALAGAPLP-NVTLDGFDLSPLLLGT-GKSPRQSLFFYPSYPDEVRGVFAV 305
Query: 473 DSGSVWKVHYTTPQFHPEGAG--ACYGRGVCPCSGEGVTHHRPPLLFDLSRDPSE 525
+G +T H + AC+ + +T H PPLL+DLS+DP E
Sbjct: 306 RTGKYKAHFFTQGSAHSDTTADPACH-------ASSSLTAHEPPLLYDLSKDPGE 353
Score = 49.3 bits (116), Expect = 1e-05
Identities = 24/57 (42%), Positives = 31/57 (54%), Gaps = 4/57 (7%)
Query: 123 GGLPENETTFARILQQHGYATGLIGKWHQGVNCASRGDHCHHPLNHGFDYFYGMPFT 179
GGLP E T A +L GY TG+ GKWH GV + P + GF F G+P++
Sbjct: 14 GGLPLEEVTVAEVLAARGYLTGMAGKWHLGVG----PEGAFLPPHQGFHRFLGIPYS 66
>gi|109389362 arylsulfatase J [Homo sapiens]
Length = 599
Score = 94.4 bits (233), Expect = 3e-19
Identities = 54/144 (37%), Positives = 84/144 (58%), Gaps = 12/144 (8%)
Query: 32 EPKTANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGVRLTQHLAAAPLCTP 91
EP T + +P+++ I+ADD G D+G +G+ ++TP +D+LA EGV+L + P+CTP
Sbjct: 67 EPSTTSTSQPHLIFILADDQGFRDVGYHGSE-IKTPTLDKLAAEGVKLENYYVQ-PICTP 124
Query: 92 SRAAFLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETTFARILQQHGYATGLIGKWHQ 151
SR+ F+TG++ +G+ S R Q N LP + T + L++ GY+T ++GKWH
Sbjct: 125 SRSQFITGKYQIHTGLQHSI-IRPTQPNC----LPLDNATLPQKLKEVGYSTHMVGKWHL 179
Query: 152 GVNCASRGDHCHHPLNHGFDYFYG 175
G C P GFD F+G
Sbjct: 180 GF----YRKEC-MPTRRGFDTFFG 198
Score = 65.9 bits (159), Expect = 1e-10
Identities = 74/316 (23%), Positives = 125/316 (39%), Gaps = 55/316 (17%)
Query: 293 PFLLFLSLLHVHIPLVTTSAFLGKSQHGL------YGDNVEEMDWLIGKVLNAIEDNGLK 346
P L+++ VH PL + + + Y + +D I V A++ G
Sbjct: 258 PIFLYIAYQAVHSPLQAPGRYFEHYRSIININRRRYAAMLSCLDEAINNVTLALKTYGFY 317
Query: 347 NSTFTYFTSDHGGHLEARDGHSQLGGWNGIYKGGKGMGGWEGGIRVPGIFHWPGVLPAGR 406
N++ ++SD+GG A GG N +G KG WEGGIR G H P + G
Sbjct: 318 NNSIIIYSSDNGGQPTA-------GGSNWPLRGSKGTY-WEGGIRAVGFVHSPLLKNKGT 369
Query: 407 VIGEPTSLMDVFPTVVQLVGGEVPQDRVIDGHSLVPLLQGAEARSAHEFLFHYCGQHLHA 466
V E + D +PT++ L G++ +D +DG+ + + RS + H
Sbjct: 370 VCKELVHITDWYPTLISLAEGQIDEDIQLDGYDIWETISEG-LRSPRVDILHNIDPIYTK 428
Query: 467 AR----------WHQKDSGSV----WKV--------HYTTPQ-FHPEGAGACYGRGVCPC 503
A+ W+ ++ WK+ + PQ F G + +
Sbjct: 429 AKNGSWAAGYGIWNTAIQSAIRVQHWKLLTGNPGYSDWVPPQSFSNLGPNRWHNERITLS 488
Query: 504 SGEGVTHHRPPLLFDLSRDPSEARPLTPDSEPLYHAVIARVGAAVSEHRQTLSPV--PQQ 561
+G+ V LF+++ DP E D Y ++ ++ +S+ +T PV P +
Sbjct: 489 TGKSV------WLFNITADPYE----RVDLSNRYPGIVKKLLRRLSQFNKTAVPVRYPPK 538
Query: 562 FSMSNI-----LWKPW 572
SN +W PW
Sbjct: 539 DPRSNPRLNGGVWGPW 554
>gi|4557659 iduronate-2-sulfatase isoform a precursor [Homo sapiens]
Length = 550
Score = 91.3 bits (225), Expect = 2e-18
Identities = 108/444 (24%), Positives = 178/444 (40%), Gaps = 73/444 (16%)
Query: 20 VLLFLCLLLKTCEPKTANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGVRL 79
VL +C+ L + + N+LLI+ DDL LGCYG+ +R+PNIDQLA +
Sbjct: 16 VLSSVCVALGSETQANSTTDALNVLLIIVDDLRPS-LGCYGDKLVRSPNIDQLASHSLLF 74
Query: 80 TQHLAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETTFARILQQH 139
A +C PSR +FLTGR + + N Y W +G N +T + +++
Sbjct: 75 QNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSY----WRVHAG----NFSTIPQYFKEN 126
Query: 140 GYATGLIGK-WHQGVNCASRGDHCHHPLNHGFDYFY--GMPFTLTNDCDPGRPPEVDAAL 196
GY T +GK +H G++ D P + F ++ + T C R P D L
Sbjct: 127 GYVTMSVGKVFHPGISSNHTDD---SPYSWSFPPYHPSSEKYENTKTC---RGP--DGEL 178
Query: 197 RAQLWGYTQFLALGILTLAAGQTCGFFSVSARAVTGMAGVGCLFFISW-----YSSFGFV 251
A L L + TL Q+ + + + M FF++ + F +
Sbjct: 179 HANLLCPVDVLDVPEGTLPDKQST---EQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYP 235
Query: 252 RRWNCIL-MRNHDVTEQPMVLEKTASLMLKEAVSYIERHKHGPFLLFLSLLHVHIPLVTT 310
+ + + + N + P V + + + +R + L++ +P
Sbjct: 236 KEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQRED-------VQALNISVPYGPI 288
Query: 311 SAFLGKSQHGLYGDNVEEMDWLIGKVLNAIEDNGLKNSTFTYFTSDHGGHLEARDGHSQL 370
+ Y +V +D +G++L+A++D L NST FTSDHG L +
Sbjct: 289 PVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWAL------GEH 342
Query: 371 GGWNGIYKGGKGMGGWEGGIRVPGIFHWPG------------------------VLPAGR 406
G W ++ VP IF+ PG ++ GR
Sbjct: 343 GEW-------AKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGR 395
Query: 407 VIGEPTSLMDVFPTVVQLVGGEVP 430
+ L+ +FPT+ L G +VP
Sbjct: 396 QSMDLVELVSLFPTLAGLAGLQVP 419
>gi|5360208 iduronate-2-sulfatase isoform b precursor [Homo sapiens]
Length = 343
Score = 85.9 bits (211), Expect = 1e-16
Identities = 89/348 (25%), Positives = 148/348 (42%), Gaps = 36/348 (10%)
Query: 20 VLLFLCLLLKTCEPKTANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGVRL 79
VL +C+ L + + N+LLI+ DDL LGCYG+ +R+PNIDQLA +
Sbjct: 16 VLSSVCVALGSETQANSTTDALNVLLIIVDDLRPS-LGCYGDKLVRSPNIDQLASHSLLF 74
Query: 80 TQHLAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETTFARILQQH 139
A +C PSR +FLTGR + + N Y W +G N +T + +++
Sbjct: 75 QNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSY----WRVHAG----NFSTIPQYFKEN 126
Query: 140 GYATGLIGK-WHQGVNCASRGDHCHHPLNHGFDYFY--GMPFTLTNDCDPGRPPEVDAAL 196
GY T +GK +H G++ D P + F ++ + T C R P D L
Sbjct: 127 GYVTMSVGKVFHPGISSNHTDD---SPYSWSFPPYHPSSEKYENTKTC---RGP--DGEL 178
Query: 197 RAQLWGYTQFLALGILTLAAGQTCGFFSVSARAVTGMAGVGCLFFISW-----YSSFGFV 251
A L L + TL Q+ + + + M FF++ + F +
Sbjct: 179 HANLLCPVDVLDVPEGTLPDKQST---EQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYP 235
Query: 252 RRWNCIL-MRNHDVTEQPMVLEKTASLMLKEAVSYIERHKHGPFLLFLSLLHVHIPLVTT 310
+ + + + N + P V + + + +R + L++ +P
Sbjct: 236 KEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQRED-------VQALNISVPYGPI 288
Query: 311 SAFLGKSQHGLYGDNVEEMDWLIGKVLNAIEDNGLKNSTFTYFTSDHG 358
+ Y +V +D +G++L+A++D L NST FTSDHG
Sbjct: 289 PVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHG 336
>gi|4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo
sapiens]
Length = 502
Score = 61.6 bits (148), Expect = 2e-09
Identities = 42/135 (31%), Positives = 63/135 (46%), Gaps = 12/135 (8%)
Query: 18 LPVLLFLCLLLKTCEPKTANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGV 77
+P L L+L C + NA LL++ADD G + G Y N+ + TP++D LA +
Sbjct: 5 VPACCALLLVLGLCRARPRNA-----LLLLADD-GGFESGAYNNSAIATPHLDALARRSL 58
Query: 78 RLTQHLAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETTFARILQ 137
+ C+PSRA+ LTG ++GM L + + + +L
Sbjct: 59 LFRNAFTSVSSCSPSRASLLTGLPQHQNGM------YGLHQDVHHFNSFDKVRSLPLLLS 112
Query: 138 QHGYATGLIGKWHQG 152
Q G TG+IGK H G
Sbjct: 113 QAGVRTGIIGKKHVG 127
Score = 35.0 bits (79), Expect = 0.19
Identities = 58/265 (21%), Positives = 89/265 (33%), Gaps = 61/265 (23%)
Query: 301 LHVHIPLVTTSAFLGKSQHGLYGDNVEEMDWLIGKVLNAIEDNGLKNSTFTYFTSDHGGH 360
L V +P + ++ V MD +G VL + D G+ N T FTSD+G
Sbjct: 218 LDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLVLQELRDAGVLNDTLVIFTSDNG-- 275
Query: 361 LEARDGHSQLGGWNGIYKGGKGMGGWEGGIRVPGIFHWPGVLPA------------GRVI 408
+ G + L +WPG G+V
Sbjct: 276 IPFPSGRTNL--------------------------YWPGTAEPLLVSSPEHPKRWGQVS 309
Query: 409 GEPTSLMDVFPTVVQLVGGEVPQDRV-------IDGHSLVPLLQGAE-------ARSAHE 454
SL+D+ PT++ P + + G SL+P L+ ++S HE
Sbjct: 310 EAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPALEAEPLWATVFGSQSHHE 369
Query: 455 FLFHY---CGQHLHAARWHQKDSGSVWKVH---YTTPQFHPEGAGACYGRGVCPCSGEGV 508
Y QH H H + + + Y +P F G+
Sbjct: 370 VTMSYPMRSVQHRHFRLVHNLNFKMPFPIDQDFYVSPTFQDLLNRTTAGQPTGWYKDLRH 429
Query: 509 THHRPPL-LFDLSRDPSEARPLTPD 532
++R L+D SRDP E + L D
Sbjct: 430 YYYRARWELYDRSRDPHETQNLATD 454
>gi|39930577 arylsulfatase K [Homo sapiens]
Length = 536
Score = 52.8 bits (125), Expect = 9e-07
Identities = 38/128 (29%), Positives = 62/128 (48%), Gaps = 16/128 (12%)
Query: 316 KSQHGLYGDNVEEMDWLIGKVLNAIEDNGLKNSTFTYFTSDHGGHLEARDGHSQLGGWNG 375
K+ Y E D ++G+++ A+ L T ++SDHG E H Q
Sbjct: 273 KNIRAFYYAMCAETDAMLGEIILALHQLDLLQKTIVIYSSDHG---ELAMEHRQF----- 324
Query: 376 IYKGGKGMGGWEGGIRVPGIFHWPGVLPAGRVIGEPTSLMDVFPTVVQLVGGEVPQDRVI 435
YK M +E VP + PG+ AG + SL+D++PT++ + G +PQ+ +
Sbjct: 325 -YK----MSMYEASAHVPLLMMGPGI-KAGLQVSNVVSLVDIYPTMLDIAGIPLPQN--L 376
Query: 436 DGHSLVPL 443
G+SL+PL
Sbjct: 377 SGYSLLPL 384
Score = 47.4 bits (111), Expect = 4e-05
Identities = 31/117 (26%), Positives = 52/117 (44%), Gaps = 11/117 (9%)
Query: 32 EPKTANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGVRLTQHLAAAPLCTP 91
E + A PN++L+++D G+ ++ P I+ + G +P+C P
Sbjct: 23 EQRRRAAKAPNVVLVVSDSFDGRLTFHPGSQVVKLPFINFMKTRGTSFLNAYTNSPICCP 82
Query: 92 SRAAFLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETTFARILQQHGYATGLIGK 148
SRAA +G + + WN GL N TT+ ++++HGY T GK
Sbjct: 83 SRAAMWSGLFT----------HLTESWN-NFKGLDPNYTTWMDVMERHGYRTQKFGK 128
>gi|169217295 PREDICTED: similar to iduronate 2-sulfatase (Hunter
syndrome) [Homo sapiens]
Length = 142
Score = 50.1 bits (118), Expect = 6e-06
Identities = 30/90 (33%), Positives = 45/90 (50%), Gaps = 9/90 (10%)
Query: 64 LRTPNIDQLAEEGVRLTQHLAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWNAGSG 123
++ PNIDQLA + A +C PSR +FLTGR + + N Y W +G
Sbjct: 22 VKAPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSY----WRVHAG 77
Query: 124 GLPENETTFARILQQHGYATGLIGK-WHQG 152
N +T + +++GY T +GK +H G
Sbjct: 78 ----NFSTIPQYFKENGYVTMSVGKVFHPG 103
>gi|189571643 sulfatase 1 [Homo sapiens]
Length = 871
Score = 47.8 bits (112), Expect = 3e-05
Identities = 34/116 (29%), Positives = 60/116 (51%), Gaps = 15/116 (12%)
Query: 329 MDWLIGKVLNAIEDNGLKNSTFTYFTSDHGGHLEARDGHSQLGGWNGIYKGGKGMGGWEG 388
+D + ++ N + + G +T+ +T+DHG H+ G G+ K GK M ++
Sbjct: 289 VDDSVERLYNMLVETGELENTYIIYTADHGYHI----------GQFGLVK-GKSM-PYDF 336
Query: 389 GIRVPGIFHWPGVLPAGRVIGEPTSLMDVFPTVVQLVGGEVPQDRVIDGHSLVPLL 444
IRVP P V P G ++ + +D+ PT++ + G + P D +DG S++ LL
Sbjct: 337 DIRVPFFIRGPSVEP-GSIVPQIVLNIDLAPTILDIAGLDTPPD--VDGKSVLKLL 389
Score = 41.2 bits (95), Expect = 0.003
Identities = 32/113 (28%), Positives = 49/113 (43%), Gaps = 14/113 (12%)
Query: 40 KPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEE--GVRLTQHLAAAPLCTPSRAAFL 97
+PNI+L++ DD +LG +L+ N + E G P+C PSR++ L
Sbjct: 42 RPNIILVLTDDQDV-ELG-----SLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSML 95
Query: 98 TGRHSFRSGMDASN-GYRALQWNAGSGGLPENETTFARILQQHGYATGLIGKW 149
TG++ + +N + W A TFA L GY T GK+
Sbjct: 96 TGKYVHNHNVYTNNENCSSPSWQA-----MHEPRTFAVYLNNTGYRTAFFGKY 143
>gi|189571641 sulfatase 1 [Homo sapiens]
Length = 871
Score = 47.8 bits (112), Expect = 3e-05
Identities = 34/116 (29%), Positives = 60/116 (51%), Gaps = 15/116 (12%)
Query: 329 MDWLIGKVLNAIEDNGLKNSTFTYFTSDHGGHLEARDGHSQLGGWNGIYKGGKGMGGWEG 388
+D + ++ N + + G +T+ +T+DHG H+ G G+ K GK M ++
Sbjct: 289 VDDSVERLYNMLVETGELENTYIIYTADHGYHI----------GQFGLVK-GKSM-PYDF 336
Query: 389 GIRVPGIFHWPGVLPAGRVIGEPTSLMDVFPTVVQLVGGEVPQDRVIDGHSLVPLL 444
IRVP P V P G ++ + +D+ PT++ + G + P D +DG S++ LL
Sbjct: 337 DIRVPFFIRGPSVEP-GSIVPQIVLNIDLAPTILDIAGLDTPPD--VDGKSVLKLL 389
Score = 41.2 bits (95), Expect = 0.003
Identities = 32/113 (28%), Positives = 49/113 (43%), Gaps = 14/113 (12%)
Query: 40 KPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEE--GVRLTQHLAAAPLCTPSRAAFL 97
+PNI+L++ DD +LG +L+ N + E G P+C PSR++ L
Sbjct: 42 RPNIILVLTDDQDV-ELG-----SLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSML 95
Query: 98 TGRHSFRSGMDASN-GYRALQWNAGSGGLPENETTFARILQQHGYATGLIGKW 149
TG++ + +N + W A TFA L GY T GK+
Sbjct: 96 TGKYVHNHNVYTNNENCSSPSWQA-----MHEPRTFAVYLNNTGYRTAFFGKY 143
>gi|189571638 sulfatase 1 [Homo sapiens]
Length = 871
Score = 47.8 bits (112), Expect = 3e-05
Identities = 34/116 (29%), Positives = 60/116 (51%), Gaps = 15/116 (12%)
Query: 329 MDWLIGKVLNAIEDNGLKNSTFTYFTSDHGGHLEARDGHSQLGGWNGIYKGGKGMGGWEG 388
+D + ++ N + + G +T+ +T+DHG H+ G G+ K GK M ++
Sbjct: 289 VDDSVERLYNMLVETGELENTYIIYTADHGYHI----------GQFGLVK-GKSM-PYDF 336
Query: 389 GIRVPGIFHWPGVLPAGRVIGEPTSLMDVFPTVVQLVGGEVPQDRVIDGHSLVPLL 444
IRVP P V P G ++ + +D+ PT++ + G + P D +DG S++ LL
Sbjct: 337 DIRVPFFIRGPSVEP-GSIVPQIVLNIDLAPTILDIAGLDTPPD--VDGKSVLKLL 389
Score = 41.2 bits (95), Expect = 0.003
Identities = 32/113 (28%), Positives = 49/113 (43%), Gaps = 14/113 (12%)
Query: 40 KPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEE--GVRLTQHLAAAPLCTPSRAAFL 97
+PNI+L++ DD +LG +L+ N + E G P+C PSR++ L
Sbjct: 42 RPNIILVLTDDQDV-ELG-----SLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSML 95
Query: 98 TGRHSFRSGMDASN-GYRALQWNAGSGGLPENETTFARILQQHGYATGLIGKW 149
TG++ + +N + W A TFA L GY T GK+
Sbjct: 96 TGKYVHNHNVYTNNENCSSPSWQA-----MHEPRTFAVYLNNTGYRTAFFGKY 143
>gi|189571636 sulfatase 1 [Homo sapiens]
Length = 871
Score = 47.8 bits (112), Expect = 3e-05
Identities = 34/116 (29%), Positives = 60/116 (51%), Gaps = 15/116 (12%)
Query: 329 MDWLIGKVLNAIEDNGLKNSTFTYFTSDHGGHLEARDGHSQLGGWNGIYKGGKGMGGWEG 388
+D + ++ N + + G +T+ +T+DHG H+ G G+ K GK M ++
Sbjct: 289 VDDSVERLYNMLVETGELENTYIIYTADHGYHI----------GQFGLVK-GKSM-PYDF 336
Query: 389 GIRVPGIFHWPGVLPAGRVIGEPTSLMDVFPTVVQLVGGEVPQDRVIDGHSLVPLL 444
IRVP P V P G ++ + +D+ PT++ + G + P D +DG S++ LL
Sbjct: 337 DIRVPFFIRGPSVEP-GSIVPQIVLNIDLAPTILDIAGLDTPPD--VDGKSVLKLL 389
Score = 41.2 bits (95), Expect = 0.003
Identities = 32/113 (28%), Positives = 49/113 (43%), Gaps = 14/113 (12%)
Query: 40 KPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEE--GVRLTQHLAAAPLCTPSRAAFL 97
+PNI+L++ DD +LG +L+ N + E G P+C PSR++ L
Sbjct: 42 RPNIILVLTDDQDV-ELG-----SLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSML 95
Query: 98 TGRHSFRSGMDASN-GYRALQWNAGSGGLPENETTFARILQQHGYATGLIGKW 149
TG++ + +N + W A TFA L GY T GK+
Sbjct: 96 TGKYVHNHNVYTNNENCSSPSWQA-----MHEPRTFAVYLNNTGYRTAFFGKY 143
>gi|240255483 sulfatase 2 isoform a precursor [Homo sapiens]
Length = 870
Score = 43.5 bits (101), Expect = 5e-04
Identities = 34/109 (31%), Positives = 56/109 (51%), Gaps = 15/109 (13%)
Query: 336 VLNAIEDNGLKNSTFTYFTSDHGGHLEARDGHSQLGGWNGIYKGGKGMGGWEGGIRVPGI 395
+ N + + G ++T+ +T+DHG H+ G G+ K GK M +E IRVP
Sbjct: 297 IYNMLVETGELDNTYIVYTADHGYHI----------GQFGLVK-GKSM-PYEFDIRVPFY 344
Query: 396 FHWPGVLPAGRVIGEPTSLMDVFPTVVQLVGGEVPQDRVIDGHSLVPLL 444
P V AG + +D+ PT++ + G ++P D +DG S++ LL
Sbjct: 345 VRGPNV-EAGCLNPHIVLNIDLAPTILDIAGLDIPAD--MDGKSILKLL 390
Score = 42.7 bits (99), Expect = 0.001
Identities = 32/113 (28%), Positives = 47/113 (41%), Gaps = 14/113 (12%)
Query: 40 KPNILLIMADDLGTGDLGCYG--NNTLRTPNIDQLAEEGVRLTQHLAAAPLCTPSRAAFL 97
+PNI+L++ DD +LG N T R + + G P+C PSR++ L
Sbjct: 43 RPNIILVLTDDQDV-ELGSMQVMNKTRRI-----MEQGGAHFINAFVTTPMCCPSRSSIL 96
Query: 98 TGRHSFRSGMDASN-GYRALQWNAGSGGLPENETTFARILQQHGYATGLIGKW 149
TG++ +N + W A TFA L GY T GK+
Sbjct: 97 TGKYVHNHNTYTNNENCSSPSWQA-----QHESRTFAVYLNSTGYRTAFFGKY 144
>gi|240255478 sulfatase 2 isoform b precursor [Homo sapiens]
Length = 867
Score = 43.5 bits (101), Expect = 5e-04
Identities = 34/109 (31%), Positives = 56/109 (51%), Gaps = 15/109 (13%)
Query: 336 VLNAIEDNGLKNSTFTYFTSDHGGHLEARDGHSQLGGWNGIYKGGKGMGGWEGGIRVPGI 395
+ N + + G ++T+ +T+DHG H+ G G+ K GK M +E IRVP
Sbjct: 297 IYNMLVETGELDNTYIVYTADHGYHI----------GQFGLVK-GKSM-PYEFDIRVPFY 344
Query: 396 FHWPGVLPAGRVIGEPTSLMDVFPTVVQLVGGEVPQDRVIDGHSLVPLL 444
P V AG + +D+ PT++ + G ++P D +DG S++ LL
Sbjct: 345 VRGPNV-EAGCLNPHIVLNIDLAPTILDIAGLDIPAD--MDGKSILKLL 390
Score = 42.7 bits (99), Expect = 0.001
Identities = 32/113 (28%), Positives = 47/113 (41%), Gaps = 14/113 (12%)
Query: 40 KPNILLIMADDLGTGDLGCYG--NNTLRTPNIDQLAEEGVRLTQHLAAAPLCTPSRAAFL 97
+PNI+L++ DD +LG N T R + + G P+C PSR++ L
Sbjct: 43 RPNIILVLTDDQDV-ELGSMQVMNKTRRI-----MEQGGAHFINAFVTTPMCCPSRSSIL 96
Query: 98 TGRHSFRSGMDASN-GYRALQWNAGSGGLPENETTFARILQQHGYATGLIGKW 149
TG++ +N + W A TFA L GY T GK+
Sbjct: 97 TGKYVHNHNTYTNNENCSSPSWQA-----QHESRTFAVYLNSTGYRTAFFGKY 144
>gi|29789100 sulfatase 2 isoform a precursor [Homo sapiens]
Length = 870
Score = 43.5 bits (101), Expect = 5e-04
Identities = 34/109 (31%), Positives = 56/109 (51%), Gaps = 15/109 (13%)
Query: 336 VLNAIEDNGLKNSTFTYFTSDHGGHLEARDGHSQLGGWNGIYKGGKGMGGWEGGIRVPGI 395
+ N + + G ++T+ +T+DHG H+ G G+ K GK M +E IRVP
Sbjct: 297 IYNMLVETGELDNTYIVYTADHGYHI----------GQFGLVK-GKSM-PYEFDIRVPFY 344
Query: 396 FHWPGVLPAGRVIGEPTSLMDVFPTVVQLVGGEVPQDRVIDGHSLVPLL 444
P V AG + +D+ PT++ + G ++P D +DG S++ LL
Sbjct: 345 VRGPNV-EAGCLNPHIVLNIDLAPTILDIAGLDIPAD--MDGKSILKLL 390
Score = 42.7 bits (99), Expect = 0.001
Identities = 32/113 (28%), Positives = 47/113 (41%), Gaps = 14/113 (12%)
Query: 40 KPNILLIMADDLGTGDLGCYG--NNTLRTPNIDQLAEEGVRLTQHLAAAPLCTPSRAAFL 97
+PNI+L++ DD +LG N T R + + G P+C PSR++ L
Sbjct: 43 RPNIILVLTDDQDV-ELGSMQVMNKTRRI-----MEQGGAHFINAFVTTPMCCPSRSSIL 96
Query: 98 TGRHSFRSGMDASN-GYRALQWNAGSGGLPENETTFARILQQHGYATGLIGKW 149
TG++ +N + W A TFA L GY T GK+
Sbjct: 97 TGKYVHNHNTYTNNENCSSPSWQA-----QHESRTFAVYLNSTGYRTAFFGKY 144
>gi|4504061 glucosamine (N-acetyl)-6-sulfatase precursor [Homo
sapiens]
Length = 552
Score = 43.5 bits (101), Expect = 5e-04
Identities = 32/119 (26%), Positives = 64/119 (53%), Gaps = 14/119 (11%)
Query: 329 MDWLIGKVLNAIEDNGLKNSTFTYFTSDHGGHLEARDGHSQLGGWNGIYKGGKGMGGWEG 388
+D L+ K++ +E G N+T+ ++TSD+G H G + + + +E
Sbjct: 299 VDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHT----------GQFSLPIDKRQL--YEF 346
Query: 389 GIRVPGIFHWPGVLPAGRVIGEPTSLMDVFPTVVQLVGGEVPQDRVIDGHSLVPLLQGA 447
I+VP + PG+ P + + +D+ PT++ + G ++ + ++ DG SL+P+L+GA
Sbjct: 347 DIKVPLLVRGPGIKP-NQTSKMLVANIDLGPTILDIAGYDLNKTQM-DGMSLLPILRGA 403
Score = 41.2 bits (95), Expect = 0.003
Identities = 38/144 (26%), Positives = 59/144 (40%), Gaps = 13/144 (9%)
Query: 36 ANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGVRLTQHLAAAPLCTPSRAA 95
A +PN++L++ DD G T + E G+ + + LC PSRA+
Sbjct: 42 AGTRRPNVVLLLTDDQDE----VLGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRAS 97
Query: 96 FLTGRHSFRSGMDASNGYRALQWNAGSGGLP--ENETTFARILQQH-GYATGLIGKWHQG 152
LTG++ + + L+ N S + TF IL+ GY T GK+
Sbjct: 98 ILTGKYPHNHHVVNN----TLEGNCSSKSWQKIQEPNTFPAILRSMCGYQTFFAGKYLNE 153
Query: 153 VNCASRGDHCHHPLNHGFDYFYGM 176
G H PL G+ Y+Y +
Sbjct: 154 YGAPDAGGLEHVPL--GWSYWYAL 175
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.139 0.460
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,796,164
Number of Sequences: 37866
Number of extensions: 1301407
Number of successful extensions: 2817
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 22
Number of HSP's successfully gapped in prelim test: 25
Number of HSP's that attempted gapping in prelim test: 2680
Number of HSP's gapped (non-prelim): 81
length of query: 593
length of database: 18,247,518
effective HSP length: 108
effective length of query: 485
effective length of database: 14,157,990
effective search space: 6866625150
effective search space used: 6866625150
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.