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Search of human proteins with 65289632
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
(694 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 1425 0.0
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 1384 0.0
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 1291 0.0
gi|14780904 kelch-like 1 protein [Homo sapiens] 857 0.0
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 838 0.0
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 815 0.0
gi|40807500 kelch-like 20 [Homo sapiens] 478 e-134
gi|38194229 kelch-like 17 [Homo sapiens] 456 e-128
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 414 e-115
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 414 e-115
gi|55925604 kelch-like 18 [Homo sapiens] 413 e-115
gi|166235129 kelch-like 3 [Homo sapiens] 412 e-115
gi|34101268 kelch-like 8 [Homo sapiens] 397 e-110
gi|11056006 kelch-like 12 [Homo sapiens] 395 e-110
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 393 e-109
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 391 e-108
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 352 5e-97
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 352 5e-97
gi|148664209 kelch-like 10 [Homo sapiens] 316 4e-86
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 304 2e-82
gi|223890235 intracisternal A particle-promoted polypeptide isof... 291 1e-78
gi|45643138 kelch-like 13 [Homo sapiens] 282 6e-76
gi|24308181 kelch-like 9 [Homo sapiens] 279 5e-75
gi|40018614 DRE1 protein [Homo sapiens] 277 3e-74
gi|55925608 kelch-like 21 [Homo sapiens] 248 2e-65
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens] 244 2e-64
gi|109150407 kelch-like 6 [Homo sapiens] 242 1e-63
gi|8922854 kelch-like 26 [Homo sapiens] 241 2e-63
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 238 1e-62
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens] 238 1e-62
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 1425 bits (3689), Expect = 0.0
Identities = 694/694 (100%), Positives = 694/694 (100%)
Query: 1 MNVIYFPLHIFVVYSRAYTSLVLVGCTNLCAVLFARCLDDHLVSLRMSGSRKEFDVKQIL 60
MNVIYFPLHIFVVYSRAYTSLVLVGCTNLCAVLFARCLDDHLVSLRMSGSRKEFDVKQIL
Sbjct: 1 MNVIYFPLHIFVVYSRAYTSLVLVGCTNLCAVLFARCLDDHLVSLRMSGSRKEFDVKQIL 60
Query: 61 KIRWRWFGHQASSPNSTVDSQQGEFWNRGQTGANGGRKFLDPCSLQLPLASIGYRRSSQL 120
KIRWRWFGHQASSPNSTVDSQQGEFWNRGQTGANGGRKFLDPCSLQLPLASIGYRRSSQL
Sbjct: 61 KIRWRWFGHQASSPNSTVDSQQGEFWNRGQTGANGGRKFLDPCSLQLPLASIGYRRSSQL 120
Query: 121 DFQNSPSWPMASTSEVPAFEFTAEDCGGAHWLDRPEVDDGTSEEENESDSSSCRLVLSSV 180
DFQNSPSWPMASTSEVPAFEFTAEDCGGAHWLDRPEVDDGTSEEENESDSSSCRLVLSSV
Sbjct: 121 DFQNSPSWPMASTSEVPAFEFTAEDCGGAHWLDRPEVDDGTSEEENESDSSSCRLVLSSV 180
Query: 181 SDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQ 240
SDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQ
Sbjct: 181 SDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQ 240
Query: 241 LSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLL 300
LSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLL
Sbjct: 241 LSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLL 300
Query: 301 PASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD 360
PASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD
Sbjct: 301 PASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD 360
Query: 361 MENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGA 420
MENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGA
Sbjct: 361 MENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGA 420
Query: 421 TSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTW 480
TSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTW
Sbjct: 421 TSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTW 480
Query: 481 SVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTV 540
SVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTV
Sbjct: 481 SVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTV 540
Query: 541 GVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIG 600
GVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIG
Sbjct: 541 GVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIG 600
Query: 601 GHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAY 660
GHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAY
Sbjct: 601 GHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAY 660
Query: 661 LNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL 694
LNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL
Sbjct: 661 LNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL 694
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 1384 bits (3581), Expect = 0.0
Identities = 691/755 (91%), Positives = 693/755 (91%), Gaps = 61/755 (8%)
Query: 1 MNVIYFPLHIFVVYSRAYTSLVLVGCTNLCAVLFARCLDDHLVSLRMSGSRKEFDVKQIL 60
MNVIYFPLHIFVVYSRAYTSLVLVGCTNLCAVLFARCLDDHLVSLRMSGSRKEFDVKQIL
Sbjct: 1 MNVIYFPLHIFVVYSRAYTSLVLVGCTNLCAVLFARCLDDHLVSLRMSGSRKEFDVKQIL 60
Query: 61 KIRWRWFGHQASSPNSTVDSQQGEFWNRGQTGANGGRKFLDPCSLQLPLASIGYRRSSQL 120
KIRWRWFGHQASSPNSTVDSQQGEFWNRGQTGANGGRKFLDPCSLQLPLASIGYRRSSQL
Sbjct: 61 KIRWRWFGHQASSPNSTVDSQQGEFWNRGQTGANGGRKFLDPCSLQLPLASIGYRRSSQL 120
Query: 121 DFQNSPSWPMASTSEVPAFEFTAEDCGGAHWLDRPEVDDGTSEE--ENESDS-------- 170
DFQNSPSWPMASTSEVPAFEFTAEDCGGAHWLDRPEVDDGTSEE E++S S
Sbjct: 121 DFQNSPSWPMASTSEVPAFEFTAEDCGGAHWLDRPEVDDGTSEEENESDSSSCRTSNSSQ 180
Query: 171 --SSC-------------------------------------------------RLVLSS 179
SSC RLVLSS
Sbjct: 181 TLSSCHTMEPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSS 240
Query: 180 VSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLL 239
VSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLL
Sbjct: 241 VSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLL 300
Query: 240 QLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVL 299
QLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVL
Sbjct: 301 QLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVL 360
Query: 300 LPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLA 359
LPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLA
Sbjct: 361 LPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLA 420
Query: 360 DMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKG 419
DMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKG
Sbjct: 421 DMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKG 480
Query: 420 ATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKT 479
ATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKT
Sbjct: 481 ATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKT 540
Query: 480 WSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRST 539
WSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRST
Sbjct: 541 WSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRST 600
Query: 540 VGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAI 599
VGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAI
Sbjct: 601 VGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAI 660
Query: 600 GGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQA 659
GGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQA
Sbjct: 661 GGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQA 720
Query: 660 YLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL 694
YLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL
Sbjct: 721 YLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL 755
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 1291 bits (3340), Expect = 0.0
Identities = 645/709 (90%), Positives = 647/709 (91%), Gaps = 61/709 (8%)
Query: 47 MSGSRKEFDVKQILKIRWRWFGHQASSPNSTVDSQQGEFWNRGQTGANGGRKFLDPCSLQ 106
MSGSRKEFDVKQILKIRWRWFGHQASSPNSTVDSQQGEFWNRGQTGANGGRKFLDPCSLQ
Sbjct: 1 MSGSRKEFDVKQILKIRWRWFGHQASSPNSTVDSQQGEFWNRGQTGANGGRKFLDPCSLQ 60
Query: 107 LPLASIGYRRSSQLDFQNSPSWPMASTSEVPAFEFTAEDCGGAHWLDRPEVDDGTSEE-- 164
LPLASIGYRRSSQLDFQNSPSWPMASTSEVPAFEFTAEDCGGAHWLDRPEVDDGTSEE
Sbjct: 61 LPLASIGYRRSSQLDFQNSPSWPMASTSEVPAFEFTAEDCGGAHWLDRPEVDDGTSEEEN 120
Query: 165 ENESDS----------SSC----------------------------------------- 173
E++S S SSC
Sbjct: 121 ESDSSSCRTSNSSQTLSSCHTMEPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVA 180
Query: 174 --------RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELK 225
RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELK
Sbjct: 181 GDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELK 240
Query: 226 EDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTM 285
EDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTM
Sbjct: 241 EDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTM 300
Query: 286 EHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLL 345
EHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLL
Sbjct: 301 EHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLL 360
Query: 346 AYIRLPLLAPQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTV 405
AYIRLPLLAPQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTV
Sbjct: 361 AYIRLPLLAPQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTV 420
Query: 406 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLK 465
GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLK
Sbjct: 421 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLK 480
Query: 466 TLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQAR 525
TLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQAR
Sbjct: 481 TLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQAR 540
Query: 526 QWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRG 585
QWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRG
Sbjct: 541 QWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRG 600
Query: 586 GVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLL 645
GVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLL
Sbjct: 601 GVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLL 660
Query: 646 GDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL 694
GDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL
Sbjct: 661 GDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL 709
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 857 bits (2213), Expect = 0.0
Identities = 404/520 (77%), Positives = 464/520 (89%)
Query: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
RLVLSSVSDYFAAMFT+DV EA+QEEIKMEG++PN+LW L+Q+AYTG LELKED IE LL
Sbjct: 227 RLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLL 286
Query: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
+ ACLLQL QVVE CC FLMK LHPSNCLGIR+FADAQGC +L KVAH+YTME+ MEVIR
Sbjct: 287 AAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIR 346
Query: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353
NQEF+LLPA E+ KLLASDD+N+P+EETI +AL+ WV++D++ R DLS LLA+IRLPLL
Sbjct: 347 NQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLL 406
Query: 354 APQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGG 413
PQ LAD+EN+ LF++D+ECQKLI+EAMKYHLLPERR ++QSPRTKPRKSTVGTL+AVGG
Sbjct: 407 PPQILADLENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGG 466
Query: 414 MDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECY 473
MD+ KGAT+IEKYDLRTN+W MNGRRLQFGVAV+DDKL+V+GGRDGLKTLNTVECY
Sbjct: 467 MDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECY 526
Query: 474 NPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATM 533
NPKTKTW+V+PPMSTHRHGLGV VLEGP+YAVGGHDGWSYLNTVERWDPQ++QW FVA+M
Sbjct: 527 NPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASM 586
Query: 534 STPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWN 593
S RSTVGVA L+GKLY+VGGRDGSSCL S+E +DPHTNKW +CA M KRRGGVGV T +
Sbjct: 587 SIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCD 646
Query: 594 GLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVG 653
G LYA+GGHDAPASN SRL D VERYDPKTD WT VA +S+ RDAVGVCLLGD+LYAVG
Sbjct: 647 GFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVG 706
Query: 654 GYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVK 693
GYDGQ YLNT+E+YDPQTNEWTQ+A L +GRAGACVV +K
Sbjct: 707 GYDGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVVIK 746
Score = 76.3 bits (186), Expect = 9e-14
Identities = 41/102 (40%), Positives = 61/102 (59%), Gaps = 6/102 (5%)
Query: 406 GTLFAVGGMDS------TKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVG 459
G L+AVGG D+ ++ +E+YD +T+ WT VA ++ R GV +L D+LY VG
Sbjct: 647 GFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVG 706
Query: 460 GRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGP 501
G DG LNT+E Y+P+T W+ M ++ R G V V++ P
Sbjct: 707 GYDGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVVIKQP 748
Score = 37.4 bits (85), Expect = 0.047
Identities = 17/28 (60%), Positives = 22/28 (78%), Gaps = 1/28 (3%)
Query: 47 MSGS-RKEFDVKQILKIRWRWFGHQASS 73
MSGS RK+FDVK IL++RW+ F H + S
Sbjct: 1 MSGSGRKDFDVKHILRLRWKLFSHPSPS 28
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 838 bits (2165), Expect = 0.0
Identities = 394/521 (75%), Positives = 453/521 (86%)
Query: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
RLVLS+VSDYFAAMFTNDV EA+QEE++MEGV+PN+L SL+QYAYTG L+LKED IE LL
Sbjct: 197 RLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLL 256
Query: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
+ ACLLQL+QV++ C FL+KQLHPSNCLGIRSF DAQGCT+L VAH YTMEHF+EVI+
Sbjct: 257 AAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIK 316
Query: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353
NQEF+LLPA+EI+KLL SDD+N+P+EETI +AL+ WV HD++ R+ +L LL+YIRLPLL
Sbjct: 317 NQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLL 376
Query: 354 APQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGG 413
PQ LAD+E + +F D+ECQKL+MEAMKYHLLPERR M+QSPRTKPRKSTVG L+AVGG
Sbjct: 377 PPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGG 436
Query: 414 MDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECY 473
MD+ KG T+IEKYDLRTN W + MNGRRLQFGVAV+D+KLYVVGGRDGLKTLNTVEC+
Sbjct: 437 MDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECF 496
Query: 474 NPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATM 533
NP K W+VMPPMSTHRHGLGVA LEGPMYAVGGHDGWSYLNTVERWDP+ RQWN+VA+M
Sbjct: 497 NPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASM 556
Query: 534 STPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWN 593
STPRSTVGV L+ KLYA+GGRDGSSCLKS+E FDPHTNKW+LCA MSKRRGGVGV T+N
Sbjct: 557 STPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYN 616
Query: 594 GLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVG 653
G LY +GGHDAPASN SRLSDCVERYDPK D W+ VA +S+ RDAV VC LGDKLY VG
Sbjct: 617 GFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVG 676
Query: 654 GYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL 694
GYDG YLNTVE+YD Q NEW + P+ +GRAGACVV VKL
Sbjct: 677 GYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVVVKL 717
Score = 65.9 bits (159), Expect = 1e-10
Identities = 51/154 (33%), Positives = 75/154 (48%), Gaps = 19/154 (12%)
Query: 363 NNVLF----RDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTV-----GTLFAVGG 413
NN L+ RD C K +M+Y + L +P +K R G L+ VGG
Sbjct: 569 NNKLYAIGGRDGSSCLK----SMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGG 624
Query: 414 MDS------TKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTL 467
D+ ++ + +E+YD + + W+ VA ++ R V L DKLYVVGG DG L
Sbjct: 625 HDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYL 684
Query: 468 NTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGP 501
NTVE Y+ + W P++ R G V V++ P
Sbjct: 685 NTVESYDAQRNEWKEEVPVNIGRAGACVVVVKLP 718
Score = 45.1 bits (105), Expect = 2e-04
Identities = 21/48 (43%), Positives = 26/48 (54%)
Query: 51 RKEFDVKQILKIRWRWFGHQASSPNSTVDSQQGEFWNRGQTGANGGRK 98
+KEFDVKQIL++RWRWF H +T Q E + T G K
Sbjct: 6 KKEFDVKQILRLRWRWFSHPFQGSTNTGSCLQQEGYEHRGTPVQGRLK 53
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 815 bits (2105), Expect = 0.0
Identities = 382/503 (75%), Positives = 439/503 (87%)
Query: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
RLVLS+VSDYFAAMFTNDV EA+QEE++MEGV+PN+L SL+QYAYTG L+LKED IE LL
Sbjct: 197 RLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLL 256
Query: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
+ ACLLQL+QV++ C FL+KQLHPSNCLGIRSF DAQGCT+L VAH YTMEHF+EVI+
Sbjct: 257 AAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIK 316
Query: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353
NQEF+LLPA+EI+KLL SDD+N+P+EETI +AL+ WV HD++ R+ +L LL+YIRLPLL
Sbjct: 317 NQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLL 376
Query: 354 APQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGG 413
PQ LAD+E + +F D+ECQKL+MEAMKYHLLPERR M+QSPRTKPRKSTVG L+AVGG
Sbjct: 377 PPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGG 436
Query: 414 MDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECY 473
MD+ KG T+IEKYDLRTN W + MNGRRLQFGVAV+D+KLYVVGGRDGLKTLNTVEC+
Sbjct: 437 MDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECF 496
Query: 474 NPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATM 533
NP K W+VMPPMSTHRHGLGVA LEGPMYAVGGHDGWSYLNTVERWDP+ RQWN+VA+M
Sbjct: 497 NPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASM 556
Query: 534 STPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWN 593
STPRSTVGV L+ KLYA+GGRDGSSCLKS+E FDPHTNKW+LCA MSKRRGGVGV T+N
Sbjct: 557 STPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYN 616
Query: 594 GLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVG 653
G LY +GGHDAPASN SRLSDCVERYDPK D W+ VA +S+ RDAV VC LGDKLY VG
Sbjct: 617 GFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVG 676
Query: 654 GYDGQAYLNTVEAYDPQTNEWTQ 676
GYDG YLNTVE+YD Q NEW +
Sbjct: 677 GYDGHTYLNTVESYDAQRNEWKE 699
Score = 168 bits (425), Expect = 2e-41
Identities = 87/192 (45%), Positives = 113/192 (58%), Gaps = 6/192 (3%)
Query: 500 GPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSS 559
G +YAVGG D T+E++D + W + TM+ R GVAV+ KLY VGGRDG
Sbjct: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLK 488
Query: 560 CLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVER 619
L +VECF+P WT+ MS R G+GV T G +YA+GGHD + T VER
Sbjct: 489 TLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNT------VER 542
Query: 620 YDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAP 679
+DP+ W VASMS R VGV L +KLYA+GG DG + L ++E +DP TN+W+ AP
Sbjct: 543 WDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAP 602
Query: 680 LCLGRAGACVVT 691
+ R G V T
Sbjct: 603 MSKRRGGVGVAT 614
Score = 102 bits (253), Expect = 2e-21
Identities = 58/160 (36%), Positives = 84/160 (52%), Gaps = 7/160 (4%)
Query: 533 MSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTW 592
M +PR+ + + G LYAVGG D ++E +D TN W M+ RR GV
Sbjct: 416 MQSPRTKPRKSTV-GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVI 474
Query: 593 NGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAV 652
+ LY +GG D + + VE ++P +WT + MS R +GV L +YAV
Sbjct: 475 DNKLYVVGGRDG------LKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAV 528
Query: 653 GGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTV 692
GG+DG +YLNTVE +DP+ +W VA + R+ VV +
Sbjct: 529 GGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVAL 568
Score = 73.6 bits (179), Expect = 6e-13
Identities = 39/100 (39%), Positives = 56/100 (56%), Gaps = 6/100 (6%)
Query: 594 GLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVG 653
G LYA+GG DA T +E+YD +T+ W + +M+ R GV ++ +KLY VG
Sbjct: 429 GALYAVGGMDAMKGTTT------IEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVG 482
Query: 654 GYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVK 693
G DG LNTVE ++P WT + P+ R G V T++
Sbjct: 483 GRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLE 522
Score = 45.1 bits (105), Expect = 2e-04
Identities = 21/48 (43%), Positives = 26/48 (54%)
Query: 51 RKEFDVKQILKIRWRWFGHQASSPNSTVDSQQGEFWNRGQTGANGGRK 98
+KEFDVKQIL++RWRWF H +T Q E + T G K
Sbjct: 6 KKEFDVKQILRLRWRWFSHPFQGSTNTGSCLQQEGYEHRGTPVQGRLK 53
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 478 bits (1229), Expect = e-134
Identities = 240/525 (45%), Positives = 351/525 (66%), Gaps = 10/525 (1%)
Query: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
R++LS+ S YF AMFT ++ E+RQ E+ + ++ ++ LI +AYT ++ ++E N++ LL
Sbjct: 83 RVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLL 142
Query: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
ACLLQL+++ EACC+FL +QL PSNCLGIR+FAD C +L ++A +T +F EV+
Sbjct: 143 PAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVME 202
Query: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353
++EF+LLPA+++ +++SD++N+ +EE + NA++ WV++ +++RR L ++L ++RLPLL
Sbjct: 203 SEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLL 262
Query: 354 APQFL-ADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRK--STVGTLFA 410
+P+FL + ++ L + D EC+ L+ EA Y LLP+ RP++Q PRT+PRK LFA
Sbjct: 263 SPKFLVGTVGSDPLIKSDEECRDLVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFA 322
Query: 411 VGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTV 470
VGG S +S+E+YD +TN W VA+M+ RR GV+VLDD LY VGG DG LN+V
Sbjct: 323 VGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSV 382
Query: 471 ECYNPKTKTWSV-MPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNF 529
E Y+PKT WS + P ST R +GVAVL G +YAVGG DG S LN VER+DP+ +W
Sbjct: 383 ERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTR 442
Query: 530 VATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGV 589
VA+MST R V VAVL G LYAVGG DG+S L +VE ++P N+W A M RR +G
Sbjct: 443 VASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGC 502
Query: 590 TTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKL 649
+ ++YA+GG D T+ LS ERY+P+T+ W+ V +M+ R VG+ ++ +L
Sbjct: 503 AVYQDMIYAVGGRDD-----TTELSS-AERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQL 556
Query: 650 YAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL 694
AVGG+DG YL T+E +DP N W + R G V +K+
Sbjct: 557 MAVGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRRLGGGVGVIKM 601
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 456 bits (1172), Expect = e-128
Identities = 237/524 (45%), Positives = 332/524 (63%), Gaps = 9/524 (1%)
Query: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
++VL+S S YF AMFTN++ E+RQ + + ++P +L L+Q+AYT + + E N++ LL
Sbjct: 107 KVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLL 166
Query: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
A LLQL+ V +ACCKFL+ QL PSNCLGIR FADA C+DL K AH Y ++HF++V +
Sbjct: 167 PAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAK 226
Query: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353
+EF+LLP ++ +L++SD +N+P+EE + A+L+WV+HD++ RR+ + +L+ +RLPLL
Sbjct: 227 TEEFMLLPLKQVLELVSSDSLNVPSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLL 286
Query: 354 APQF-LADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRK--STVGTLFA 410
+ F L ++ L R +C+ L++EA+K+HLLPE+R +L + RT+PR+ LFA
Sbjct: 287 SRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFA 346
Query: 411 VGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTV 470
VGG E YD RT+ W VA+M+ RR + GVA + ++LY VGG DG L TV
Sbjct: 347 VGGGSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATV 406
Query: 471 ECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFV 530
E Y+P T TW M T R LGVA L G +Y+ GG+DG S LN+ ER+DP W V
Sbjct: 407 ESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSV 466
Query: 531 ATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVT 590
A MST R V VA L G LYAVGG D SS L +VE ++P N W+ A M RR GV
Sbjct: 467 AAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVA 526
Query: 591 TWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLY 650
G LY GG+D TS L+ VERY PK W +VA M+I R + + LY
Sbjct: 527 VLEGALYVAGGNDG-----TSCLNS-VERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLY 580
Query: 651 AVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL 694
AVGG DG + LN++E Y+P+TN+W + + R+ V ++L
Sbjct: 581 AVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVLEL 624
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 414 bits (1064), Expect = e-115
Identities = 219/532 (41%), Positives = 330/532 (62%), Gaps = 12/532 (2%)
Query: 167 ESDSSSCRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKE 226
+ + S+ R+VL++ S YF AMFT ++ E+R + ++++ V+ +L LI Y YT +++ E
Sbjct: 68 DMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTE 127
Query: 227 DNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTME 286
+N++ LL A LLQL V + CC+FL QLHP NCLGIR+FAD CTDL A+ Y +
Sbjct: 128 ENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQ 187
Query: 287 HFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLA 346
HF +V+ ++EF+ L ++ L++SD + I +EE + A++ WV HD + R++ +++L+
Sbjct: 188 HFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLME 247
Query: 347 YIRLPLLAPQFLAD-MENNVLFRDDIECQKLIMEAMKYHLLP-ERRPMLQSPRTKPR-KS 403
++RLPLL ++L +E L ++ C+ ++EAMKYHLLP E+R +++S RT+ R
Sbjct: 248 HVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPM 307
Query: 404 TVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDG 463
+ L V G + K S+E YD + W VA + RR + G+ + ++ VGG +G
Sbjct: 308 NLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNG 367
Query: 464 LKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQ 523
+ TV+ Y+P W+ + M R LG AVL G +YAVGG DG + L++VE ++ +
Sbjct: 368 SLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIK 427
Query: 524 ARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSS--CLKSVECFDPHTNKWTLCAQMS 581
+ +W VA M+T RS+VGV V+ G LYAVGG DG+S CL +VEC++ TN+WT A+MS
Sbjct: 428 SNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMS 487
Query: 582 KRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVG 641
RR G GV N LLYA+GGHD P + VE YDP T+ W VA M++ R G
Sbjct: 488 TRRSGAGVGVLNNLLYAVGGHDGPL------VRKSVEVYDPTTNAWRQVADMNMCRRNAG 541
Query: 642 VCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAP-LCLGRAGACVVTV 692
VC + LY VGG DG L +VE Y+P T++WT V+ + GR+ A V +
Sbjct: 542 VCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVI 593
Score = 35.8 bits (81), Expect = 0.14
Identities = 20/51 (39%), Positives = 29/51 (56%), Gaps = 1/51 (1%)
Query: 406 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVAN-MNGRRLQFGVAVLDDKL 455
G L+ VGG D + S+E Y+ T+ WT V++ M+ R GV V+D L
Sbjct: 547 GLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL 597
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 414 bits (1064), Expect = e-115
Identities = 219/532 (41%), Positives = 330/532 (62%), Gaps = 12/532 (2%)
Query: 167 ESDSSSCRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKE 226
+ + S+ R+VL++ S YF AMFT ++ E+R + ++++ V+ +L LI Y YT +++ E
Sbjct: 64 DMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTE 123
Query: 227 DNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTME 286
+N++ LL A LLQL V + CC+FL QLHP NCLGIR+FAD CTDL A+ Y +
Sbjct: 124 ENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQ 183
Query: 287 HFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLA 346
HF +V+ ++EF+ L ++ L++SD + I +EE + A++ WV HD + R++ +++L+
Sbjct: 184 HFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLME 243
Query: 347 YIRLPLLAPQFLAD-MENNVLFRDDIECQKLIMEAMKYHLLP-ERRPMLQSPRTKPR-KS 403
++RLPLL ++L +E L ++ C+ ++EAMKYHLLP E+R +++S RT+ R
Sbjct: 244 HVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPM 303
Query: 404 TVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDG 463
+ L V G + K S+E YD + W VA + RR + G+ + ++ VGG +G
Sbjct: 304 NLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNG 363
Query: 464 LKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQ 523
+ TV+ Y+P W+ + M R LG AVL G +YAVGG DG + L++VE ++ +
Sbjct: 364 SLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIK 423
Query: 524 ARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSS--CLKSVECFDPHTNKWTLCAQMS 581
+ +W VA M+T RS+VGV V+ G LYAVGG DG+S CL +VEC++ TN+WT A+MS
Sbjct: 424 SNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMS 483
Query: 582 KRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVG 641
RR G GV N LLYA+GGHD P + VE YDP T+ W VA M++ R G
Sbjct: 484 TRRSGAGVGVLNNLLYAVGGHDGPL------VRKSVEVYDPTTNAWRQVADMNMCRRNAG 537
Query: 642 VCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAP-LCLGRAGACVVTV 692
VC + LY VGG DG L +VE Y+P T++WT V+ + GR+ A V +
Sbjct: 538 VCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVI 589
Score = 35.8 bits (81), Expect = 0.14
Identities = 20/51 (39%), Positives = 29/51 (56%), Gaps = 1/51 (1%)
Query: 406 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVAN-MNGRRLQFGVAVLDDKL 455
G L+ VGG D + S+E Y+ T+ WT V++ M+ R GV V+D L
Sbjct: 543 GLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL 593
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 413 bits (1061), Expect = e-115
Identities = 214/528 (40%), Positives = 319/528 (60%), Gaps = 10/528 (1%)
Query: 171 SSCRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIE 230
S+ R+VL++ YF AMFTND+ E +Q+EI M+G++P++L +LI +AY G L + + N++
Sbjct: 50 SAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQ 109
Query: 231 CLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFME 290
LL A LQL + +ACC FL ++LHP NCLG+R FA+ C L+ A+++ +HF+E
Sbjct: 110 SLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVE 169
Query: 291 VIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRL 350
V ++EF+ LP ++ +L++ D++N+ +EE + A L WVR+D EQR L +LL+ IRL
Sbjct: 170 VSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRGPYLPELLSNIRL 229
Query: 351 PLLAPQFLAD-MENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPR--KSTVGT 407
PL PQFL+D ++ + L R +C+ L+ EA YHL+PERRP L + RT+PR S G
Sbjct: 230 PLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMPERRPHLPAFRTRPRCCTSIAGL 289
Query: 408 LFAVGGMDSTKGATS-IEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKT 466
++AVGG++S + + +E +D N W M R + GVAV++ LY +GG DG
Sbjct: 290 IYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDGQLR 349
Query: 467 LNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQ 526
L+TVE YNP+T TW+ + M++ R +G VL+G +Y GG+DG S L++VE + P+ +
Sbjct: 350 LSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDK 409
Query: 527 WNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGG 586
W V +MS+ RS GV V G++Y GG DG SVE ++ HT W A M +R
Sbjct: 410 WTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCR 469
Query: 587 VGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLG 646
G + ++ GG+D S E Y D W + M R V +
Sbjct: 470 HGAASLGSKMFVCGGYDG------SGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASC 523
Query: 647 DKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL 694
+LYAVGGYDGQ+ L++VE YDP+T+ WT +AP+ G V + L
Sbjct: 524 GRLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPMACHEGGVGVGCIPL 571
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 412 bits (1058), Expect = e-115
Identities = 219/526 (41%), Positives = 323/526 (61%), Gaps = 14/526 (2%)
Query: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
R+VL++ S YF AMFT D+ E++ ++I+++ V+ +L LI Y YT +E+ E+N++ LL
Sbjct: 65 RVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLL 124
Query: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
A LLQL V + CC FL QLHP+NCLGIR+FAD CTDL + A+ Y +HF EV+
Sbjct: 125 PAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVML 184
Query: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353
+EF+ L ++ L++SD + + +EE + A+++W+ ++ E R + ++KL+ ++RLPLL
Sbjct: 185 GEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWINYEKETRLEHMAKLMEHVRLPLL 244
Query: 354 APQFLAD-MENNVLFRDDIECQKLIMEAMKYHLLP-ERRPMLQSPRTKPRK--STVGTLF 409
+L +E L +++ C+ ++EAMKYHLLP ++R ++++PRTKPR S +
Sbjct: 245 PRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMI 304
Query: 410 AVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNT 469
VGG + K S+E YD + W +A + RR + GV + +Y VGG +G + T
Sbjct: 305 VVGG-QAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRT 363
Query: 470 VECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNF 529
V+ Y+ W+ + M R LG AVL +YAVGG DG + L +VE + + +W F
Sbjct: 364 VDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFF 423
Query: 530 VATMSTPRSTVGVAVLSGKLYAVGGRDGSS--CLKSVECFDPHTNKWTLCAQMSKRRGGV 587
VA M+T RS+VGV V+ GKLYAVGG DG+S CL +VE ++P TN+W A MS RR G
Sbjct: 424 VAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGA 483
Query: 588 GVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGD 647
GV +G LYA GGHD P + VE YDP T+ W VA M++ R GVC +
Sbjct: 484 GVGVLSGQLYATGGHDGPL------VRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNG 537
Query: 648 KLYAVGGYDGQAYLNTVEAYDPQTNEWTQV-APLCLGRAGACVVTV 692
LY VGG DG L +VE Y+P T++WT + + GR+ A V +
Sbjct: 538 LLYVVGGDDGSCNLASVEYYNPVTDKWTLLPTNMSTGRSYAGVAVI 583
Score = 102 bits (254), Expect = 1e-21
Identities = 59/161 (36%), Positives = 83/161 (51%), Gaps = 6/161 (3%)
Query: 533 MSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTW 592
+ PR+ V K+ V G ++SVEC+D ++W A++ RR GV
Sbjct: 286 IKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFM 345
Query: 593 NGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAV 652
G +YA+GG + T V+ YD D WT++ASM R +G +L D LYAV
Sbjct: 346 AGHVYAVGGFNGSLRVRT------VDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAV 399
Query: 653 GGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVK 693
GG+DG L +VEAY +TNEW VAP+ R+ V V+
Sbjct: 400 GGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVE 440
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 397 bits (1021), Expect = e-110
Identities = 214/526 (40%), Positives = 314/526 (59%), Gaps = 16/526 (3%)
Query: 172 SC-RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIE 230
SC +LVL+ V YF AMF +++ EA+Q I++ + +++ L+++ Y+ RL L DN++
Sbjct: 79 SCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQ 138
Query: 231 CLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFME 290
LL AC+LQ+ V ACC+++ HPSNCL +R+FA++ DL +A Y +HF E
Sbjct: 139 PLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTE 198
Query: 291 VIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRL 350
V+ ++FV + + KLL+S D+NI NE+ + NA + W+ + + K L + LA +RL
Sbjct: 199 VVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHSKWLDETLAQVRL 258
Query: 351 PLLAPQFLADM-ENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQ---SPRTKPRKSTVG 406
PLL FL + + + +++C+ L+ EA YHL R + S RT PRK T G
Sbjct: 259 PLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSRAVPDFEYSIRTTPRKHTAG 318
Query: 407 TLFAVGGMDSTKGA-TSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLK 465
LF VGG + SIE Y + N W MN RR GV ++ K+Y VGG DG +
Sbjct: 319 VLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNE 378
Query: 466 TLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQAR 525
L ++E ++P T W + M+T R G+ +A L GP+YA+GG D + N VER+D ++
Sbjct: 379 HLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESD 438
Query: 526 QWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRG 585
QW+ VA M+TPR VG L +YAVGG DG + L SVE +DPH +KW +M +RR
Sbjct: 439 QWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRA 498
Query: 586 GVGVTTWNGLLYAIGGHD--APASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVC 643
G GV+ +G LY +GG D +P S+ VERYDP+++ W VA+++ R VG+
Sbjct: 499 GNGVSKLHGCLYVVGGFDDNSPLSS--------VERYDPRSNKWDYVAALTTPRGGVGIA 550
Query: 644 LLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACV 689
+ K++AVGG++G AYLNTVEA+DP N W V + RAGA V
Sbjct: 551 TVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGV 596
Score = 119 bits (297), Expect = 1e-26
Identities = 60/142 (42%), Positives = 87/142 (61%)
Query: 405 VGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGL 464
V ++AVGG D +S+E+YD + W V M RR GV+ L LYVVGG D
Sbjct: 459 VNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDN 518
Query: 465 KTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQA 524
L++VE Y+P++ W + ++T R G+G+A + G ++AVGGH+G +YLNTVE +DP
Sbjct: 519 SPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVL 578
Query: 525 RQWNFVATMSTPRSTVGVAVLS 546
+W V ++S R+ GVAV S
Sbjct: 579 NRWELVGSVSHCRAGAGVAVCS 600
Score = 32.3 bits (72), Expect = 1.5
Identities = 21/59 (35%), Positives = 31/59 (52%), Gaps = 1/59 (1%)
Query: 393 LQSPRTKPRKSTV-GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAV 450
L +PR +TV G +FAVGG + ++E +D N W V +++ R GVAV
Sbjct: 540 LTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAV 598
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 395 bits (1015), Expect = e-110
Identities = 203/534 (38%), Positives = 311/534 (58%), Gaps = 13/534 (2%)
Query: 167 ESDSSSCRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKE 226
+ D + R+VL++ SDYF AMFT+++ E + + ++G+ +++ L+ + YT + +
Sbjct: 41 QKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYVDIQGLTASTMEILLDFVYTETVHVTV 100
Query: 227 DNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTME 286
+N++ LL ACLLQL V +ACC+FL QL PSNCLGIR FA+ C DL + A ++ +
Sbjct: 101 ENVQELLPAACLLQLKGVKQACCEFLESQLDPSNCLGIRDFAETHNCVDLMQAAEVFSQK 160
Query: 287 HFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLA 346
HF EV++++EF+LL E+ KL+ D++ + +EE + A++ WV+H ++R + L LL
Sbjct: 161 HFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEEPVFEAVINWVKHAKKEREESLPNLLQ 220
Query: 347 YIRLPLLAPQFLAD-MENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTV 405
Y+R+PLL P+++ D ++ R ++C+ L+ EA K+HL PE R +Q PRT+ R
Sbjct: 221 YVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDEAKKFHLRPELRSQMQGPRTRARLGAN 280
Query: 406 GTLFAVGGMDSTKGATS-IEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGL 464
L VGG S + +EKYD +T W+ + ++ +R L D++YV+GG DG
Sbjct: 281 EVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGR 340
Query: 465 KTLNTVECYN---PKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWD 521
L++VEC + + W + PM+ R G L +Y GG DG ++ER+D
Sbjct: 341 SRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYD 400
Query: 522 PQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMS 581
P QW+ + M T R G+ V SG +Y +GG DG + L SVE +DPHT WT M+
Sbjct: 401 PNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMA 460
Query: 582 KRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVG 641
+R G GV N +Y +GG D T+ LS VE Y+ +TD WT V SM+ R VG
Sbjct: 461 TKRSGAGVALLNDHIYVVGGFDG-----TAHLSS-VEAYNIRTDSWTTVTSMTTPRCYVG 514
Query: 642 VCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGR--AGACVVTVK 693
+L +LYA+ GYDG + L+++E YDP + W V + R AG CV+ K
Sbjct: 515 ATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQRCDAGVCVLREK 568
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 393 bits (1010), Expect = e-109
Identities = 208/505 (41%), Positives = 311/505 (61%), Gaps = 12/505 (2%)
Query: 194 EARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLM 253
E+R + ++++ V+ +L LI Y YT +++ E+N++ LL A LLQL V + CC+FL
Sbjct: 3 ESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLE 62
Query: 254 KQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDD 313
QLHP NCLGIR+FAD CTDL A+ Y +HF +V+ ++EF+ L ++ L++SD
Sbjct: 63 SQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDK 122
Query: 314 MNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIE 372
+ I +EE + A++ WV HD + R++ +++L+ ++RLPLL ++L +E L ++
Sbjct: 123 LTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSA 182
Query: 373 CQKLIMEAMKYHLLP-ERRPMLQSPRTKPR-KSTVGTLFAVGGMDSTKGATSIEKYDLRT 430
C+ ++EAMKYHLLP E+R +++S RT+ R + L V G + K S+E YD +
Sbjct: 183 CKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKE 242
Query: 431 NMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHR 490
W VA + RR + G+ + ++ VGG +G + TV+ Y+P W+ + M R
Sbjct: 243 ERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRR 302
Query: 491 HGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLY 550
LG AVL G +YAVGG DG + L++VE ++ ++ +W VA M+T RS+VGV V+ G LY
Sbjct: 303 STLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLY 362
Query: 551 AVGGRDGSS--CLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASN 608
AVGG DG+S CL +VEC++ TN+WT A+MS RR G GV N LLYA+GGHD P
Sbjct: 363 AVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL-- 420
Query: 609 LTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYD 668
+ VE YDP T+ W VA M++ R GVC + LY VGG DG L +VE Y+
Sbjct: 421 ----VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYN 476
Query: 669 PQTNEWTQVAP-LCLGRAGACVVTV 692
P T++WT V+ + GR+ A V +
Sbjct: 477 PTTDKWTVVSSCMSTGRSYAGVTVI 501
Score = 35.8 bits (81), Expect = 0.14
Identities = 20/51 (39%), Positives = 29/51 (56%), Gaps = 1/51 (1%)
Query: 406 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVAN-MNGRRLQFGVAVLDDKL 455
G L+ VGG D + S+E Y+ T+ WT V++ M+ R GV V+D L
Sbjct: 455 GLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL 505
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 391 bits (1004), Expect = e-108
Identities = 208/520 (40%), Positives = 318/520 (61%), Gaps = 27/520 (5%)
Query: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
++VL+SVS YF AMFT ++ E E++ + ++ +L ++++YAYTG + + +D +E LL
Sbjct: 50 KVVLASVSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTGTVFISQDTVESLL 109
Query: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
A LLQ+ V++ CC FL QL P NC+GI FA+ GC DL+ A Y ++F V +
Sbjct: 110 PAANLLQIKLVLKECCAFLESQLDPGNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQ 169
Query: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353
+EF L +++ +++++D +N+ EET+ AL +W+++D+++R+K L++LL +RLPLL
Sbjct: 170 TEEFFELTHADLDEIVSNDCLNVATEETVFYALESWIKYDVQERQKYLAQLLNSVRLPLL 229
Query: 354 APQFLADM-ENNVLFRDDIECQKLIMEAMKYHLLPERR-----PMLQSPRTKPRKSTVGT 407
+ +FL + E N L RDD C+ L+ EA+KYH +PE R ++ PR P+
Sbjct: 230 SVKFLTRLYEANHLIRDDRTCKHLLNEALKYHFMPEHRLSHQTVLMTRPRCAPK-----V 284
Query: 408 LFAVGGMDSTKGA-TSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGG-----R 461
L AVGG S+E Y + + W +A +N R +FG+ VLD K+YV+GG R
Sbjct: 285 LCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVR 344
Query: 462 DGL---KTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVE 518
G+ K N+VEC+NP T TW+ + M+ R LGV VL G +YA+GG+DG SYL +VE
Sbjct: 345 PGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVE 404
Query: 519 RWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCA 578
++ P+ R+W VA M+T RS AVL G +YA+GG G + + SVE +DP + W + A
Sbjct: 405 KYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVA 463
Query: 579 QMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRD 638
M+ +R GV G ++ +GGH+ S+L+S +ERYDP + WT M R
Sbjct: 464 SMADKRIHFGVGVMLGFIFVVGGHNG-VSHLSS-----IERYDPHQNQWTVCRPMKEPRT 517
Query: 639 AVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVA 678
VG ++ + LY VGG+ G +YLNTV+ YDP ++ W A
Sbjct: 518 GVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSA 557
Score = 142 bits (357), Expect = 1e-33
Identities = 75/185 (40%), Positives = 105/185 (56%), Gaps = 1/185 (0%)
Query: 406 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLK 465
G L+A+GG D S+EKY + W PVA M R F AVLD +Y +GG G
Sbjct: 386 GELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGY-GPA 444
Query: 466 TLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQAR 525
+N+VE Y+P +W ++ M+ R GV V+ G ++ VGGH+G S+L+++ER+DP
Sbjct: 445 HMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPHQN 504
Query: 526 QWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRG 585
QW M PR+ VG AV+ LY VGG GSS L +V+ +DP ++ W A M R
Sbjct: 505 QWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGMIYCRC 564
Query: 586 GVGVT 590
G+T
Sbjct: 565 NFGLT 569
Score = 110 bits (274), Expect = 6e-24
Identities = 55/140 (39%), Positives = 83/140 (59%), Gaps = 1/140 (0%)
Query: 406 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLK 465
G ++A+GG S+E+YD + W VA+M +R+ FGV V+ ++VVGG +G+
Sbjct: 433 GMIYAIGGYGPAH-MNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVS 491
Query: 466 TLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQAR 525
L+++E Y+P W+V PM R G+G AV++ +Y VGGH G SYLNTV+++DP +
Sbjct: 492 HLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISD 551
Query: 526 QWNFVATMSTPRSTVGVAVL 545
W A M R G+ L
Sbjct: 552 TWLDSAGMIYCRCNFGLTAL 571
Score = 95.9 bits (237), Expect = 1e-19
Identities = 60/170 (35%), Positives = 93/170 (54%), Gaps = 15/170 (8%)
Query: 522 PQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGS-SCLKSVECFDPHTNKWTLCAQM 580
P+ R + M+ PR V L AVGG+ G +CL SVE + P + W A +
Sbjct: 264 PEHRLSHQTVLMTRPRCAPKV------LCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPL 317
Query: 581 SKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLS-----DCVERYDPKTDMWTAVASMSI 635
+ R G+ + +Y IGG A+N+ ++ + VE ++P T+ WT++ M+
Sbjct: 318 NIPRYEFGICVLDQKVYVIGGI---ATNVRPGVTIRKHENSVECWNPDTNTWTSLERMNE 374
Query: 636 SRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRA 685
SR +GV +L +LYA+GGYDGQ+YL +VE Y P+ +W VAP+ R+
Sbjct: 375 SRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRS 424
Score = 70.1 bits (170), Expect = 7e-12
Identities = 38/94 (40%), Positives = 49/94 (52%)
Query: 405 VGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGL 464
+G +F VGG + +SIE+YD N WT M R G AV+D+ LYVVGG G
Sbjct: 478 LGFIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGS 537
Query: 465 KTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVL 498
LNTV+ Y+P + TW M R G+ L
Sbjct: 538 SYLNTVQKYDPISDTWLDSAGMIYCRCNFGLTAL 571
Score = 55.5 bits (132), Expect = 2e-07
Identities = 33/106 (31%), Positives = 52/106 (49%), Gaps = 13/106 (12%)
Query: 595 LLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGG 654
+L A+GG + L D VE Y P+ D W +A ++I R G+C+L K+Y +GG
Sbjct: 284 VLCAVGGKSGLFACL-----DSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGG 338
Query: 655 YDGQA--------YLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTV 692
+ N+VE ++P TN WT + + R+ VV +
Sbjct: 339 IATNVRPGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVL 384
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 352 bits (904), Expect = 5e-97
Identities = 194/521 (37%), Positives = 294/521 (56%), Gaps = 16/521 (3%)
Query: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
++VL+S S F AMFTN +RE E + +EG+ P + LI++AYT + + E + ++
Sbjct: 97 KVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVM 156
Query: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
+ A + Q+ VV AC FL++QL PSN +GI +FA+ GC +LH+ A Y HF EV +
Sbjct: 157 NGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAK 216
Query: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353
+EF L ++ L++ DD+N+ E + +A + WV++D EQRR + LL +R L
Sbjct: 217 QEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSL 276
Query: 354 APQFL-ADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVG 412
P FL ++ + + D C+ +++ + L +P P P+ VG L
Sbjct: 277 TPNFLQMQLQKCEILQSDSRCKDYLVKI--FEELTLHKPTQVMPCRAPK---VGRLIYTA 331
Query: 413 GMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGR----DGLKTLN 468
G + + +E Y+ W +A++ R V+ LY VGGR DG +
Sbjct: 332 GGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSS 391
Query: 469 TVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWN 528
++CYNP T WS PMS R+ +GV V++G +YAVGG G + N+VER++P+ +W+
Sbjct: 392 ALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWH 451
Query: 529 FVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVG 588
VA M T R VGVAVL+ LYAVGG DG++ L S EC+ P N+W + M+ R G G
Sbjct: 452 LVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAG 511
Query: 589 VTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDK 648
V + +YA GG+D L S VERYD +T+ WT VA M R A+G+ + +
Sbjct: 512 VCVLHNCIYAAGGYDG-QDQLNS-----VERYDVETETWTFVAPMKHRRSALGITVHQGR 565
Query: 649 LYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACV 689
+Y +GGYDG +L++VE YDP T+ W++V + GR+G V
Sbjct: 566 IYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGV 606
Score = 94.4 bits (233), Expect = 3e-19
Identities = 52/145 (35%), Positives = 78/145 (53%), Gaps = 5/145 (3%)
Query: 549 LYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGG-HDAPAS 607
+Y GG S L +E ++P W A + R G+ GLLYA+GG +++P
Sbjct: 328 IYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
Query: 608 NLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAY 667
N S DC Y+P T+ W+ A MS+ R+ +GV ++ +YAVGG G + N+VE Y
Sbjct: 387 NTDSSALDC---YNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERY 443
Query: 668 DPQTNEWTQVAPLCLGRAGACVVTV 692
+P+ +EW VAP+ R G V +
Sbjct: 444 EPERDEWHLVAPMLTRRIGVGVAVL 468
Score = 87.8 bits (216), Expect = 3e-17
Identities = 42/94 (44%), Positives = 58/94 (61%)
Query: 408 LFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTL 467
++A GG D S+E+YD+ T WT VA M RR G+ V ++YV+GG DG L
Sbjct: 519 IYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFL 578
Query: 468 NTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGP 501
++VECY+P T TWS + M++ R G+GVAV P
Sbjct: 579 DSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEP 612
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 352 bits (904), Expect = 5e-97
Identities = 194/521 (37%), Positives = 294/521 (56%), Gaps = 16/521 (3%)
Query: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
++VL+S S F AMFTN +RE E + +EG+ P + LI++AYT + + E + ++
Sbjct: 97 KVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVM 156
Query: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
+ A + Q+ VV AC FL++QL PSN +GI +FA+ GC +LH+ A Y HF EV +
Sbjct: 157 NGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAK 216
Query: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353
+EF L ++ L++ DD+N+ E + +A + WV++D EQRR + LL +R L
Sbjct: 217 QEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSL 276
Query: 354 APQFL-ADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVG 412
P FL ++ + + D C+ +++ + L +P P P+ VG L
Sbjct: 277 TPNFLQMQLQKCEILQSDSRCKDYLVKI--FEELTLHKPTQVMPCRAPK---VGRLIYTA 331
Query: 413 GMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGR----DGLKTLN 468
G + + +E Y+ W +A++ R V+ LY VGGR DG +
Sbjct: 332 GGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSS 391
Query: 469 TVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWN 528
++CYNP T WS PMS R+ +GV V++G +YAVGG G + N+VER++P+ +W+
Sbjct: 392 ALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWH 451
Query: 529 FVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVG 588
VA M T R VGVAVL+ LYAVGG DG++ L S EC+ P N+W + M+ R G G
Sbjct: 452 LVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAG 511
Query: 589 VTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDK 648
V + +YA GG+D L S VERYD +T+ WT VA M R A+G+ + +
Sbjct: 512 VCVLHNCIYAAGGYDG-QDQLNS-----VERYDVETETWTFVAPMKHRRSALGITVHQGR 565
Query: 649 LYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACV 689
+Y +GGYDG +L++VE YDP T+ W++V + GR+G V
Sbjct: 566 IYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGV 606
Score = 94.4 bits (233), Expect = 3e-19
Identities = 52/145 (35%), Positives = 78/145 (53%), Gaps = 5/145 (3%)
Query: 549 LYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGG-HDAPAS 607
+Y GG S L +E ++P W A + R G+ GLLYA+GG +++P
Sbjct: 328 IYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
Query: 608 NLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAY 667
N S DC Y+P T+ W+ A MS+ R+ +GV ++ +YAVGG G + N+VE Y
Sbjct: 387 NTDSSALDC---YNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERY 443
Query: 668 DPQTNEWTQVAPLCLGRAGACVVTV 692
+P+ +EW VAP+ R G V +
Sbjct: 444 EPERDEWHLVAPMLTRRIGVGVAVL 468
Score = 87.8 bits (216), Expect = 3e-17
Identities = 42/94 (44%), Positives = 58/94 (61%)
Query: 408 LFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTL 467
++A GG D S+E+YD+ T WT VA M RR G+ V ++YV+GG DG L
Sbjct: 519 IYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFL 578
Query: 468 NTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGP 501
++VECY+P T TWS + M++ R G+GVAV P
Sbjct: 579 DSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEP 612
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 316 bits (810), Expect = 4e-86
Identities = 174/534 (32%), Positives = 287/534 (53%), Gaps = 16/534 (2%)
Query: 166 NESDSSSCRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELK 225
N + S+ + +L S S YF A+FT+ ++ + G+ P+ + +I+YAYT + +
Sbjct: 46 NGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPIT 105
Query: 226 EDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTM 285
DN+E LL+ A + +V CC+FL +L NC+GI F D C +L + A+ + +
Sbjct: 106 PDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPELRQKAYMFIL 165
Query: 286 EHFMEVIR-NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKL 344
+F E+++ + EF+ L +E+ ++ D++N+ E+ + A+L W+ HD + R++ +S L
Sbjct: 166 HNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRKQHISIL 225
Query: 345 LAYIRLPLL-APQFLADMENNVLFRDDIECQKLIMEAMK----YHLLPERRPMLQSPRTK 399
L +RL L+ A F+ +++ N +D EC+ +I+ A+K ++ +P T+
Sbjct: 226 LPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMYDLNMNGPSNSDFTNPLTR 285
Query: 400 PRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVA-NMNGRRLQFGVAVLDDKLYVV 458
PR LFA+GG +IE YD R + W V R G A L +Y++
Sbjct: 286 PRLP-YAILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYII 344
Query: 459 GGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVE 518
GG D + N+V+ ++P KTW + PM + R + V VL +YA+GG DG+ LNT E
Sbjct: 345 GGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAE 404
Query: 519 RWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCA 578
R++P+ QW +A M RS L GK+Y GG +G+ CL + E ++ +N+WT+ A
Sbjct: 405 RYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIA 464
Query: 579 QMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRD 638
M RR G+GV + +YA+GG D A+ L S E Y P + W + +M R
Sbjct: 465 PMRSRRSGIGVIAYGEHVYAVGGFDG-ANRLRS-----AEAYSPVANTWRTIPTMFNPRS 518
Query: 639 AVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRA--GACVV 690
G+ ++ D L+ VGG++G VE YD +T+EW + + R+ CVV
Sbjct: 519 NFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVV 572
Score = 131 bits (330), Expect = 2e-30
Identities = 67/188 (35%), Positives = 101/188 (53%)
Query: 408 LFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTL 467
++A+GG D + E+Y+ TN WT +A M+ +R L K+Y+ GG +G + L
Sbjct: 388 IYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECL 447
Query: 468 NTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQW 527
T E YN ++ W+V+ PM + R G+GV +YAVGG DG + L + E + P A W
Sbjct: 448 FTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTW 507
Query: 528 NFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGV 587
+ TM PRS G+ V+ L+ VGG +G + +VEC+D T++W MS R +
Sbjct: 508 RTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSAL 567
Query: 588 GVTTWNGL 595
GL
Sbjct: 568 SCCVVPGL 575
Score = 94.7 bits (234), Expect = 2e-19
Identities = 51/145 (35%), Positives = 77/145 (53%), Gaps = 7/145 (4%)
Query: 549 LYAVGGRDGSSCLKSVECFDPHTNKWT-LCAQMSKRRGGVGVTTWNGLLYAIGGHDAPAS 607
L+A+GG G S ++E +D ++W + + R G G +Y IGG D+
Sbjct: 293 LFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVD- 351
Query: 608 NLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAY 667
+ V+R+DP W VA M R V V +LG+ +YA+GG+DG LNT E Y
Sbjct: 352 -----YFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERY 406
Query: 668 DPQTNEWTQVAPLCLGRAGACVVTV 692
+P+TN+WT +AP+ R+ A T+
Sbjct: 407 EPETNQWTLIAPMHEQRSDASATTL 431
Score = 92.4 bits (228), Expect = 1e-18
Identities = 47/157 (29%), Positives = 75/157 (47%)
Query: 391 PMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAV 450
PM + + G ++ GG + + + E Y+ +N WT +A M RR GV
Sbjct: 418 PMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIA 477
Query: 451 LDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDG 510
+ +Y VGG DG L + E Y+P TW +P M R G+ V++ ++ VGG +G
Sbjct: 478 YGEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNG 537
Query: 511 WSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSG 547
++ VE +D + +W MS RS + V+ G
Sbjct: 538 FTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVVPG 574
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 304 bits (779), Expect = 2e-82
Identities = 174/530 (32%), Positives = 280/530 (52%), Gaps = 24/530 (4%)
Query: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
RLVL++ S YFAA+FT ++E+ ++ + + G+E L+ + YTG + + +N++ L+
Sbjct: 52 RLVLAASSPYFAALFTGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELI 111
Query: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
A +LQL++VV CC+FL Q+ P NC+GI F++ C DL + + NY HF+EV
Sbjct: 112 IAADMLQLTEVVHLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHS 171
Query: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353
+EF+ L ++ K+L S++++I +E + A + W+ DL +RRK + ++L IR PLL
Sbjct: 172 GEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLL 231
Query: 354 APQ-FLADMENNVLFRDDIECQKLIMEAMKYHLLPERR---PMLQSPRTKPRKSTVGTLF 409
PQ L +E F + Q L+ E + P+ LQ+ + +PRK L+
Sbjct: 232 PPQRLLKYIEGVSDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLY 291
Query: 410 AVGGMDSTKGA--------TSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGR 461
AVGG +G + +E++D + WT V++++ R GV VL +Y +GG
Sbjct: 292 AVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGE 351
Query: 462 DGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWD 521
+ ECY+P TK W+ + M+ R GLGV V G +YA+GG G NT+ER+D
Sbjct: 352 KDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFD 411
Query: 522 PQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSC-LKSVECFDPHTNKWTLCAQM 580
P +W V M+ R G + G +Y +GG L+S E +DP + +W+ M
Sbjct: 412 PDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPM 471
Query: 581 SKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAV 640
RR +GV N +Y++GG N T VE+Y + + W VASM + R +
Sbjct: 472 GTRRAYLGVAALNDCIYSVGGW-----NETQDALHTVEKYSFEEEKWVEVASMKVPRAGM 526
Query: 641 GVCLLGDKLYAVGG------YDGQAYLNTVEAYDPQTNEWTQVAPLCLGR 684
V + LY GG + L++VE Y+P ++ WT++ + R
Sbjct: 527 CVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSR 576
Score = 73.9 bits (180), Expect = 5e-13
Identities = 44/123 (35%), Positives = 60/123 (48%), Gaps = 5/123 (4%)
Query: 566 CFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNL--TSRLSDCVERYDPK 623
C P NK+ Q SK R + LYA+GG+ SR CVER+D
Sbjct: 263 CKSPKENKFCSFLQTSKVRPRKKARKY---LYAVGGYTRLQGGRWSDSRALSCVERFDTF 319
Query: 624 TDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLG 683
+ WT V+S+ +R +GV +LG +YA+GG + E YDP T +WT VA +
Sbjct: 320 SQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHP 379
Query: 684 RAG 686
R G
Sbjct: 380 RCG 382
>gi|223890235 intracisternal A particle-promoted polypeptide isoform
2 [Homo sapiens]
Length = 582
Score = 291 bits (745), Expect = 1e-78
Identities = 166/494 (33%), Positives = 263/494 (53%), Gaps = 18/494 (3%)
Query: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
RLVL++ S YFAA+FT ++E+ ++ + + G+E L+ + YTG + + +N++ L+
Sbjct: 52 RLVLAASSPYFAALFTGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELI 111
Query: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
A +LQL++VV CC+FL Q+ P NC+GI F++ C DL + + NY HF+EV
Sbjct: 112 IAADMLQLTEVVHLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHS 171
Query: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353
+EF+ L ++ K+L S++++I +E + A + W+ DL +RRK + ++L IR PLL
Sbjct: 172 GEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLL 231
Query: 354 APQ-FLADMENNVLFRDDIECQKLIMEAMKYHLLPERR---PMLQSPRTKPRKSTVGTLF 409
PQ L +E F + Q L+ E + P+ LQ+ + +PRK L+
Sbjct: 232 PPQRLLKYIEGVSDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLY 291
Query: 410 AVGGMDSTKGA--------TSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGR 461
AVGG +G + +E++D + WT V++++ R GV VL +Y +GG
Sbjct: 292 AVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGE 351
Query: 462 DGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWD 521
+ ECY+P TK W+ + M+ R GLGV V G +YA+GG G NT+ER+D
Sbjct: 352 KDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFD 411
Query: 522 PQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSC-LKSVECFDPHTNKWTLCAQM 580
P +W V M+ R G + G +Y +GG L+S E +DP + +W+ M
Sbjct: 412 PDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPM 471
Query: 581 SKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAV 640
RR +GV N +Y++GG N T VE+Y + + W VASM + R +
Sbjct: 472 GTRRAYLGVAALNDCIYSVGGW-----NETQDALHTVEKYSFEEEKWVEVASMKVPRAGM 526
Query: 641 GVCLLGDKLYAVGG 654
V + LY GG
Sbjct: 527 CVVAVNGLLYVSGG 540
Score = 124 bits (311), Expect = 3e-28
Identities = 67/193 (34%), Positives = 104/193 (53%), Gaps = 15/193 (7%)
Query: 502 MYAVGGHDG-----WS---YLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVG 553
+YAVGG+ WS L+ VER+D ++ W V+++ RS +GV VL G +YA+G
Sbjct: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
Query: 554 GRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRL 613
G S EC+DP T +WT A M+ R G+GV G +YA+GG + + +
Sbjct: 350 GEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGW------VGAEI 403
Query: 614 SDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAY-LNTVEAYDPQTN 672
+ +ER+DP + W V +M++SR G C + +Y +GG + L + E YDP +
Sbjct: 404 GNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSK 463
Query: 673 EWTQVAPLCLGRA 685
W+ + P+ RA
Sbjct: 464 RWSPLPPMGTRRA 476
Score = 106 bits (265), Expect = 6e-23
Identities = 59/156 (37%), Positives = 90/156 (57%), Gaps = 4/156 (2%)
Query: 406 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGG--RDG 463
G ++A+GG + +IE++D N W V NM R FG + +YV+GG +G
Sbjct: 390 GAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEG 449
Query: 464 LKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGG-HDGWSYLNTVERWDP 522
++ L + E Y+P +K WS +PPM T R LGVA L +Y+VGG ++ L+TVE++
Sbjct: 450 IE-LRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSF 508
Query: 523 QARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGS 558
+ +W VA+M PR+ + V ++G LY GGR S
Sbjct: 509 EEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSS 544
Score = 73.9 bits (180), Expect = 5e-13
Identities = 44/123 (35%), Positives = 60/123 (48%), Gaps = 5/123 (4%)
Query: 566 CFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNL--TSRLSDCVERYDPK 623
C P NK+ Q SK R + LYA+GG+ SR CVER+D
Sbjct: 263 CKSPKENKFCSFLQTSKVRPRKKARKY---LYAVGGYTRLQGGRWSDSRALSCVERFDTF 319
Query: 624 TDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLG 683
+ WT V+S+ +R +GV +LG +YA+GG + E YDP T +WT VA +
Sbjct: 320 SQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHP 379
Query: 684 RAG 686
R G
Sbjct: 380 RCG 382
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 282 bits (722), Expect = 6e-76
Identities = 177/532 (33%), Positives = 280/532 (52%), Gaps = 17/532 (3%)
Query: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
R++++S SDYF AMFT ++E IK+ GV L +I + YT +L L DN++ L
Sbjct: 109 RVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTL 168
Query: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
A LQ+ V++ C FL+ + NC+ + A+ T++ K +++ +++F ++
Sbjct: 169 EAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLS 228
Query: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDL-SKLLAYIRLPL 352
EF+ LP +A +L+S+ + E + A W+R LE+ R D +KL+ IR PL
Sbjct: 229 TGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLR--LEEPRMDFAAKLMKNIRFPL 286
Query: 353 LAPQFLADMENNVLF-RDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAV 411
+ PQ L + V F R D C L++EA Y ++P +P++QS RT R T L +
Sbjct: 287 MTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTT-HLVTL 345
Query: 412 GGMDSTKGATS--IEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRD-----GL 464
GG+ + S + YD + + W +A M+ R Q G+AV+ + LYVVGG+ G
Sbjct: 346 GGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGK 405
Query: 465 KTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQA 524
++TV ++P+ W + ++ R ++ L+G +YAVGG + L TVE ++P+
Sbjct: 406 TAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRT 465
Query: 525 RQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRR 584
+W +VA MS P V G +Y GG + K + CFDP T+KW A M+ R
Sbjct: 466 NEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVR 525
Query: 585 GGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCL 644
G + T LY IGG+ ++ + C E Y P D WT +A+M + VGV +
Sbjct: 526 GLHCMCTVGERLYVIGGNHFRGTSDYDDVLSC-EYYSPILDQWTPIAAMLRGQSDVGVAV 584
Query: 645 LGDKLYAVGGY--DGQAYLNTVEAYDPQTNEWTQV--APLCLGRAGACVVTV 692
+K+Y VGGY + + + V+ YDP +EW +V P LG AC +TV
Sbjct: 585 FENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTV 636
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 279 bits (714), Expect = 5e-75
Identities = 176/532 (33%), Positives = 276/532 (51%), Gaps = 17/532 (3%)
Query: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
R +++S SDYF AMFT ++E IK+ GV L +I + YT +L L DN++ L
Sbjct: 67 RAMMASASDYFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTL 126
Query: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
A LQ+ V++ C FL+ + NC+ + A+ ++ K +N+ +++F ++
Sbjct: 127 EAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLS 186
Query: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKD-LSKLLAYIRLPL 352
EF+ LP +A +L+S+ + E + A W+R LE R D +KL+ IR PL
Sbjct: 187 TGEFLKLPFERLAFVLSSNSLKHCTELELFKAACRWLR--LEDPRMDYAAKLMKNIRFPL 244
Query: 353 LAPQFLADMENNVLF-RDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAV 411
+ PQ L + V F R D C L++EA Y ++P +P++QS RT R + L +
Sbjct: 245 MTPQDLINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDST-HLVTL 303
Query: 412 GGMDSTKGATS--IEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRD-----GL 464
GG+ + S + YD R W +A M+ R Q G+AV+ + LYVVGG+ G
Sbjct: 304 GGVLRQQLVVSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGK 363
Query: 465 KTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQA 524
++TV ++P+ W + ++ R ++ L+G +YAVGG L TVE ++P+
Sbjct: 364 TAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRM 423
Query: 525 RQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRR 584
+W++VA MS P V G +Y GG + + CFDP T+KW A M+ R
Sbjct: 424 NEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVR 483
Query: 585 GGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCL 644
G + T LY IGG+ ++ + C E Y P D WT +A+M + VGV +
Sbjct: 484 GLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSC-EYYSPTLDQWTPIAAMLRGQSDVGVAV 542
Query: 645 LGDKLYAVGGY--DGQAYLNTVEAYDPQTNEWTQV--APLCLGRAGACVVTV 692
+K+Y VGGY + + + V+ YDP+ +EW +V P LG AC +TV
Sbjct: 543 FENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTV 594
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 277 bits (708), Expect = 3e-74
Identities = 171/516 (33%), Positives = 277/516 (53%), Gaps = 27/516 (5%)
Query: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
R VLS+ S YF AMF ND RE+R+ +++ G+ ++ +QY YTG++++ +N++ L
Sbjct: 81 RAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLF 140
Query: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
T+ L Q+S + +AC KFL +QL P NCLGI+ FAD L N+ ++ F +V +
Sbjct: 141 ETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQ 200
Query: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353
++EF+ L E+ + SD++ I EE + A++ WV ++ RR L +LL ++RLPLL
Sbjct: 201 HEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLL 260
Query: 354 APQ-FLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKST--VGTLFA 410
P F+ +E + L ++ EC +L+ EA +YH+L + SPRT+PR+ST +
Sbjct: 261 HPNYFVQTVEVDQLIQNSPECYQLLHEARRYHILGNE---MMSPRTRPRRSTGYSEVIVV 317
Query: 411 VGGMDSTKG--ATSIEKYDLRTNMWTPVANM-NGRRLQFGVAVLDDKLYVVGGRDGLKTL 467
VGG + G E YD T W +A + + ++ V L + + V GGR +
Sbjct: 318 VGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINSR-- 375
Query: 468 NTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQW 527
V YN + W + ++ R +AVL G +Y VGG+DG + L++VE +D + +W
Sbjct: 376 -DVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRW 434
Query: 528 NFVATMSTPRSTVGVAVLSGKLYAV-GGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGG 586
VA + S+ V GKL+ + GG D ++C V+ +DP TN W L A + +
Sbjct: 435 TEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRC 494
Query: 587 VGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLG 646
+ + N L+Y GG L+ + YDP D W V + ++ G+ +
Sbjct: 495 ITAVSLNNLIYVAGG-----------LTKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCN 543
Query: 647 DKLYAVGG--YDGQAYLNTVEAYDPQTNEWTQVAPL 680
K+Y +GG +G+A +T+ YDP T+ T VA +
Sbjct: 544 GKIYILGGRRENGEA-TDTILCYDPATSIITGVAAM 578
>gi|55925608 kelch-like 21 [Homo sapiens]
Length = 597
Score = 248 bits (632), Expect = 2e-65
Identities = 168/534 (31%), Positives = 254/534 (47%), Gaps = 35/534 (6%)
Query: 159 DGTSEEENESDSSSCRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAY 218
D T E D + R VL++ S YF AMF +RE+R E +++ GV P+ L L+ ++Y
Sbjct: 36 DVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSY 95
Query: 219 TGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHK 278
TGR+ + DN E LL A LLQ V EAC FL +QL +NCL ++ FA+A C+ L
Sbjct: 96 TGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDMQDFAEAFSCSGLAS 155
Query: 279 VAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRR 338
A + + H E + ++ LP + + + L D + +P EE L WVR D +R
Sbjct: 156 AAQRFILRHVGE-LGAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRA 214
Query: 339 KDLSKLLAYIRLPLLAPQF-LADMENNVLFRDDIECQKLIMEAMKYHLLP-ERRPMLQSP 396
+LL +RLP + + LA +E L C +L+ EA + +R P
Sbjct: 215 AHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARDFQAARYDRHDRGPCP 274
Query: 397 RTKPRKST--VGTLFAVGGMD-STKGATSIEKYDLRTNMWTPVA----NMNGRRLQFGVA 449
R +PR ST L VGG D +++ Y+ +T W +A ++ G + +
Sbjct: 275 RMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGG---GYSIV 331
Query: 450 VLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHD 509
L + +YV GG DG + + V YN W+ + PM R +VL+G +Y V
Sbjct: 332 ALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAREYHSSSVLDGLLYVVAA-- 389
Query: 510 GWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDP 569
++ ER+D W + M+ P G+LYA+G G + ++C+DP
Sbjct: 390 -----DSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETM-VMQCYDP 443
Query: 570 HTNKWTL--CAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMW 627
T+ W+L C Q+ T NGL+Y + A V+ Y+P + W
Sbjct: 444 DTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVRDDSAE-----------VDVYNPTRNEW 492
Query: 628 TAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYL-NTVEAYDPQTNEWTQVAPL 680
+ SM+ + +LG KLY GGYD L + VEAYDP+T W+ V L
Sbjct: 493 DKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRL 546
Score = 56.2 bits (134), Expect = 1e-07
Identities = 42/134 (31%), Positives = 64/134 (47%), Gaps = 9/134 (6%)
Query: 406 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFG--VAVLDDKLYVVGGRDG 463
G L+A+G + + K ++ YD T++W+ V F A L+ +Y V RD
Sbjct: 422 GRLYAIGSL-AGKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFV--RDD 478
Query: 464 LKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLN-TVERWDP 522
V+ YNP W +P M+ G +AVL G +Y GG+D L+ VE +DP
Sbjct: 479 SAE---VDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDP 535
Query: 523 QARQWNFVATMSTP 536
+ R W+ V + P
Sbjct: 536 ETRAWSVVGRLPEP 549
Score = 48.9 bits (115), Expect = 2e-05
Identities = 29/94 (30%), Positives = 44/94 (46%), Gaps = 12/94 (12%)
Query: 595 LLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVG----VCLLGDKLY 650
+L +GG D L + V+ Y+P+T W +A D +G + LG+ +Y
Sbjct: 287 ILVLVGGCDQDCDELVT-----VDCYNPQTGQWRYLAEFP---DHLGGGYSIVALGNDIY 338
Query: 651 AVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGR 684
GG DG + V Y+ NEW +VAP+ R
Sbjct: 339 VTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAR 372
>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
Length = 589
Score = 244 bits (623), Expect = 2e-64
Identities = 160/515 (31%), Positives = 254/515 (49%), Gaps = 24/515 (4%)
Query: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKME-GVEPNSLWSLIQYAYTGRLELKEDNIECL 232
R VL++ S YF AMF++ +RE+R + + + + P L L+ +AY+ R+ + E+N E L
Sbjct: 61 RAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESL 120
Query: 233 LSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVI 292
L +LQ V +A +FL K L PSNCLG+ +DA C L++ + + HF V
Sbjct: 121 LEAGDMLQFHDVRDAAAEFLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVR 180
Query: 293 RNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPL 352
++++F L + L++SD++ +E + A+L WV+HDLE R+ L +LL +RL L
Sbjct: 181 QSEDFNSLSKDTLLDLISSDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLAL 240
Query: 353 LAPQFLADMENNVLFRDDIECQKLIM-EAMKYHL-LPERRPMLQSPRTKPRKSTVGTLFA 410
L L + ++ E KLIM EA++ + + ++ SP +PRK+ TL
Sbjct: 241 LPSDCLQEAVSSEALLMADERTKLIMDEALRCKTRILQNDGVVTSPCARPRKAG-HTLLI 299
Query: 411 VGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLN-T 469
+GG T I + D + P A++ R +F + + K+YV GGR ++
Sbjct: 300 LGG--QTFMCDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKD 357
Query: 470 VECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWS---------YLNTVERW 520
V Y+ + WS PM R G G A LE +Y VGGH + L VE++
Sbjct: 358 VWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKY 417
Query: 521 DPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRD-GSSCLKSVECFDPHTNKWTLCAQ 579
DP A +W VA + S V KL+ GG + V+C+DP N+WT+ A+
Sbjct: 418 DPGANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAE 477
Query: 580 MSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDA 639
+ ++ +GG T + R+D +T+ WT + M+ R +
Sbjct: 478 CPQPWRYTAAAVLGSQIFIMGGD-------TEFTAASAYRFDCETNQWTRIGDMTAKRMS 530
Query: 640 VGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEW 674
G+KLY VGGY G T++ YDP ++ W
Sbjct: 531 CHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTW 565
Score = 65.9 bits (159), Expect = 1e-10
Identities = 48/162 (29%), Positives = 71/162 (43%), Gaps = 9/162 (5%)
Query: 521 DPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCL-KSVECFDPHTNKWTLCAQ 579
D +A++ A + +PR + + K+Y GGR + + K V +D +W+ A
Sbjct: 314 DHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAP 373
Query: 580 MSKRRGGVGVTTWNGLLYAIGGHDA-----PASNLTSRLSDCVERYDPKTDMWTAVASMS 634
M R G G LY +GGH + PAS S VE+YDP + W VA +
Sbjct: 374 MLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQ--VEKYDPGANKWMMVAPLR 431
Query: 635 ISRDAVGVCLLGDKLYAVGGYD-GQAYLNTVEAYDPQTNEWT 675
V KL+ GG + ++ V+ YDP N WT
Sbjct: 432 DGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWT 473
Score = 59.7 bits (143), Expect = 9e-09
Identities = 27/74 (36%), Positives = 43/74 (58%), Gaps = 1/74 (1%)
Query: 408 LFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTL 467
+F +GG D+ A S ++D TN WT + +M +R+ +KLYVVGG G +
Sbjct: 494 IFIMGG-DTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRC 552
Query: 468 NTVECYNPKTKTWS 481
T++CY+P + TW+
Sbjct: 553 KTLDCYDPTSDTWN 566
Score = 51.6 bits (122), Expect = 2e-06
Identities = 33/84 (39%), Positives = 41/84 (48%), Gaps = 9/84 (10%)
Query: 620 YDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQA---------YLNTVEAYDPQ 670
YD + W+ A M I+R G L + LY VGG+ A L VE YDP
Sbjct: 361 YDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPG 420
Query: 671 TNEWTQVAPLCLGRAGACVVTVKL 694
N+W VAPL G + A VV+ KL
Sbjct: 421 ANKWMMVAPLRDGVSNAAVVSAKL 444
Score = 51.6 bits (122), Expect = 2e-06
Identities = 37/140 (26%), Positives = 62/140 (44%), Gaps = 4/140 (2%)
Query: 408 LFAVGGMDSTKGATS-IEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKT 466
LF GG + S ++ YD N WT A AVL +++++GG D T
Sbjct: 446 LFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGG-DTEFT 504
Query: 467 LNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQ 526
+ ++ +T W+ + M+ R +Y VGG+ G T++ +DP +
Sbjct: 505 AASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDT 564
Query: 527 WNFVATMSTPRSTVGVAVLS 546
WN + T+ P S + A +S
Sbjct: 565 WNCITTV--PYSLIPTAFVS 582
Score = 31.2 bits (69), Expect = 3.4
Identities = 19/75 (25%), Positives = 32/75 (42%), Gaps = 1/75 (1%)
Query: 613 LSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNT-VEAYDPQT 671
+ D + + D K A + R +G K+Y GG + ++ V YD
Sbjct: 306 MCDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVH 365
Query: 672 NEWTQVAPLCLGRAG 686
EW++ AP+ + R G
Sbjct: 366 EEWSKAAPMLIARFG 380
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 242 bits (617), Expect = 1e-63
Identities = 157/544 (28%), Positives = 263/544 (48%), Gaps = 44/544 (8%)
Query: 172 SC-RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIE 230
SC R+VL++ S+YF AMF ND++E ++ I ++GV+ ++ +L+ Y YT + + + N++
Sbjct: 84 SCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAETMHTLLDYTYTSKALITKQNVQ 143
Query: 231 CLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFME 290
+L A L Q ++V+AC FL + L+P NC+GI AD L K +Y +++F++
Sbjct: 144 RVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLADTHSLDSLKKQVQSYIIQNFVQ 203
Query: 291 VIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRL 350
++ ++EF+ LP + +L SDD+ + E + +++WVRH +R L +L +RL
Sbjct: 204 ILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMSWVRHKPSERLCLLPYVLENVRL 263
Query: 351 PLLAP-QFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTV-GTL 408
PLL P F+ +E + L R E L+ EA YHL + S RTKPR +
Sbjct: 264 PLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLSGNE---IISERTKPRMHEFQSEV 320
Query: 409 FAVGGMDSTKGATSIEKYDLRTNMWTP-----------------VANMNGRRLQFGVAVL 451
F + G G T E++ P + + N + ++F L
Sbjct: 321 FMIIG-----GCTKDERFVAEVTCLDPLRRSRLEVAKLPLTEHELESENKKWVEFACVTL 375
Query: 452 DDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGW 511
+++Y+ GG++ T + V YN W + ++ R + VL G +Y +GG DG
Sbjct: 376 KNEVYISGGKE---TQHDVWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVYVIGGFDGL 432
Query: 512 SYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAV-GGRDGSSCLKSVECFDPH 570
+N VE +DP W+ A + S+ KLY + GG +G +C+DP
Sbjct: 433 QRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGKLATDKTQCYDPS 492
Query: 571 TNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAV 630
TNKW+L A M + ++ +Y +GG + Y P D W V
Sbjct: 493 TNKWSLKAAMPVEAKCINAVSFRDRIYVVGG-----------AMRALYAYSPLEDSWCLV 541
Query: 631 ASMSISRDAVGVCLLGDKLYAVGGYDGQ-AYLNTVEAYDPQTNEWTQVAPLCLGRAGACV 689
+S R + G+ ++LY GG D + + TV +DP+ + T+ L G +
Sbjct: 542 TQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPEAQKLTEECVLPRGVSHHGS 601
Query: 690 VTVK 693
VT++
Sbjct: 602 VTIR 605
>gi|8922854 kelch-like 26 [Homo sapiens]
Length = 615
Score = 241 bits (615), Expect = 2e-63
Identities = 167/539 (30%), Positives = 258/539 (47%), Gaps = 30/539 (5%)
Query: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
++VL++ SDYF AMFT +REA Q+ I+++GV L +I +AY+ + L D ++ +L
Sbjct: 78 KVVLAACSDYFRAMFTGGMREASQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVL 137
Query: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
A LQ+ VVE C +FL + CL I A L + +T HF+++
Sbjct: 138 GAAVFLQMLPVVELCEEFLKAAMSVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAE 197
Query: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353
++F+ LP + L S+ + E + A + W++HD RR S +L +IR PL+
Sbjct: 198 EEDFLRLPLERLVFFLQSNRLQSCAEIDLFRAAVRWLQHD-PARRPRASHVLCHIRFPLM 256
Query: 354 APQFLADMENNV-LFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVG 412
L D + + +D+ C++ ++EA Y +LP R+ +QSPRT R S V +L G
Sbjct: 257 QSSELVDSVQTLDIMVEDVLCRQYLLEAFNYQVLPFRQHEMQSPRTAVR-SDVPSLVTFG 315
Query: 413 GMDSTKGATSIEK--YDL---RTNMWTPVANMNGRRLQFGVAVLDDKLYVVGG-----RD 462
G T S+ Y L + + M VAVLD+ +YV GG R
Sbjct: 316 GTPYTDSDRSVSSKVYQLPEPGARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRS 375
Query: 463 GLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDP 522
G ++ Y+P W + M R + VL G +YA GG + L +VER+ P
Sbjct: 376 GEGAVDACYRYDPHLNRWLRLQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCP 435
Query: 523 QARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGS-SCLKSVECFDPHTNKWTLCAQMS 581
+ +W + ++ A G+LY GG S K++ C+DP ++W A MS
Sbjct: 436 RRNEWGYACSLKRRTWGHAGAASGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMS 495
Query: 582 KRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVG 641
+ R + G +YA+GG L+ VE Y P+TD WT+V+ M + G
Sbjct: 496 EPRVLHAMVGAGGRIYALGGRMDHVDRCFDVLA--VEYYVPETDQWTSVSPMRAGQSEAG 553
Query: 642 VCLLGDKLYAVGGYDGQA--YLNTVEAYDPQTNEWTQ------------VAPLCLGRAG 686
CLL K+Y VGGY+ + V+ Y+ T+EW + AP+ L RAG
Sbjct: 554 CCLLERKIYIVGGYNWRLNNVTGIVQVYNTDTDEWERDLHFPESFAGIACAPVLLPRAG 612
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 238 bits (607), Expect = 1e-62
Identities = 148/526 (28%), Positives = 258/526 (49%), Gaps = 18/526 (3%)
Query: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
R+VL++ S +F MFT ++ E++ E++++ EP+ + L+++AYT R+ + +N++ LL
Sbjct: 59 RVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLL 118
Query: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
A Q+ V + C FL +Q+ SNCLGI A+ C +L A ++ +HF EV +
Sbjct: 119 DAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYK 178
Query: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353
EF+ L + LL D + + E+ + +A + W+++D R+ + +LA +R PL+
Sbjct: 179 TDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLI 238
Query: 354 APQFLA-DMENNVLFRDDIECQKLIMEAMKYHLL-PERRPMLQSPRTKPRKSTVGTLFAV 411
+ FL+ ++ L +D+ EC K+++ M+YHLL PE R L T+PR+ A+
Sbjct: 239 SKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREELVD-GTRPRRKKHDYRIAL 297
Query: 412 GGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVE 471
G + S ++ + WT + +R D+ +Y++GG L + ++
Sbjct: 298 FGGSQPQ---SCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQ-LFPIKRMD 353
Query: 472 CYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHD-GWSYLNTVERWDPQARQWNFV 530
CYN +W T R L EG +Y GG + G S L E +D + W+
Sbjct: 354 CYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTK 413
Query: 531 ATMSTPRSTVGVAVLSGKLYAVGGRDGSS----CLKSVECFDPHTNKWTLCAQMSKRRGG 586
+M T R + G+ +G +Y GG G++ L S E +DP T WT M + R
Sbjct: 414 PSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKN 473
Query: 587 VGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLG 646
G+ ++A+GG + D VE YD K + W V+ M V +G
Sbjct: 474 HGLVFVKDKIFAVGGQNGLGG------LDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVG 527
Query: 647 DKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTV 692
+Y + G+ G L + Y+ +T++W + + +C++ V
Sbjct: 528 SIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVRAFPVTSCLICV 573
Score = 57.8 bits (138), Expect = 3e-08
Identities = 46/188 (24%), Positives = 73/188 (38%), Gaps = 10/188 (5%)
Query: 510 GWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDP 569
G S + ++P+ W + R +Y +GG +K ++C++
Sbjct: 299 GGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFP-IKRMDCYNV 357
Query: 570 HTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTA 629
+ W R + G +Y GG + S L L +C YD +T+ W
Sbjct: 358 VKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALY--LFEC---YDTRTESWHT 412
Query: 630 VASMSISRDAVGVCLLGDKLYAVGGYDGQ----AYLNTVEAYDPQTNEWTQVAPLCLGRA 685
SM R + G+ +Y GG G LN+ E YDP T WT++ P+ R
Sbjct: 413 KPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARK 472
Query: 686 GACVVTVK 693
+V VK
Sbjct: 473 NHGLVFVK 480
>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
Length = 564
Score = 238 bits (607), Expect = 1e-62
Identities = 148/526 (28%), Positives = 258/526 (49%), Gaps = 18/526 (3%)
Query: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
R+VL++ S +F MFT ++ E++ E++++ EP+ + L+++AYT R+ + +N++ LL
Sbjct: 37 RVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLL 96
Query: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
A Q+ V + C FL +Q+ SNCLGI A+ C +L A ++ +HF EV +
Sbjct: 97 DAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYK 156
Query: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353
EF+ L + LL D + + E+ + +A + W+++D R+ + +LA +R PL+
Sbjct: 157 TDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLI 216
Query: 354 APQFLA-DMENNVLFRDDIECQKLIMEAMKYHLL-PERRPMLQSPRTKPRKSTVGTLFAV 411
+ FL+ ++ L +D+ EC K+++ M+YHLL PE R L T+PR+ A+
Sbjct: 217 SKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREELVD-GTRPRRKKHDYRIAL 275
Query: 412 GGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVE 471
G + S ++ + WT + +R D+ +Y++GG L + ++
Sbjct: 276 FGGSQPQ---SCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQ-LFPIKRMD 331
Query: 472 CYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHD-GWSYLNTVERWDPQARQWNFV 530
CYN +W T R L EG +Y GG + G S L E +D + W+
Sbjct: 332 CYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTK 391
Query: 531 ATMSTPRSTVGVAVLSGKLYAVGGRDGSS----CLKSVECFDPHTNKWTLCAQMSKRRGG 586
+M T R + G+ +G +Y GG G++ L S E +DP T WT M + R
Sbjct: 392 PSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKN 451
Query: 587 VGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLG 646
G+ ++A+GG + D VE YD K + W V+ M V +G
Sbjct: 452 HGLVFVKDKIFAVGGQNGLGG------LDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVG 505
Query: 647 DKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTV 692
+Y + G+ G L + Y+ +T++W + + +C++ V
Sbjct: 506 SIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVRAFPVTSCLICV 551
Score = 57.8 bits (138), Expect = 3e-08
Identities = 46/188 (24%), Positives = 73/188 (38%), Gaps = 10/188 (5%)
Query: 510 GWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDP 569
G S + ++P+ W + R +Y +GG +K ++C++
Sbjct: 277 GGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFP-IKRMDCYNV 335
Query: 570 HTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTA 629
+ W R + G +Y GG + S L L +C YD +T+ W
Sbjct: 336 VKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALY--LFEC---YDTRTESWHT 390
Query: 630 VASMSISRDAVGVCLLGDKLYAVGGYDGQ----AYLNTVEAYDPQTNEWTQVAPLCLGRA 685
SM R + G+ +Y GG G LN+ E YDP T WT++ P+ R
Sbjct: 391 KPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARK 450
Query: 686 GACVVTVK 693
+V VK
Sbjct: 451 NHGLVFVK 458
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,765,784
Number of Sequences: 37866
Number of extensions: 1177158
Number of successful extensions: 4214
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 136
Number of HSP's successfully gapped in prelim test: 35
Number of HSP's that attempted gapping in prelim test: 2690
Number of HSP's gapped (non-prelim): 412
length of query: 694
length of database: 18,247,518
effective HSP length: 109
effective length of query: 585
effective length of database: 14,120,124
effective search space: 8260272540
effective search space used: 8260272540
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.