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Search of human proteins with 65289292
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
(755 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 1551 0.0
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 1458 0.0
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 1384 0.0
gi|14780904 kelch-like 1 protein [Homo sapiens] 942 0.0
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 926 0.0
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 903 0.0
gi|40807500 kelch-like 20 [Homo sapiens] 508 e-144
gi|38194229 kelch-like 17 [Homo sapiens] 474 e-133
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 439 e-123
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 439 e-123
gi|166235129 kelch-like 3 [Homo sapiens] 438 e-122
gi|55925604 kelch-like 18 [Homo sapiens] 435 e-122
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 420 e-117
gi|34101268 kelch-like 8 [Homo sapiens] 416 e-116
gi|11056006 kelch-like 12 [Homo sapiens] 415 e-116
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 393 e-109
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 368 e-101
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 368 e-101
gi|148664209 kelch-like 10 [Homo sapiens] 328 1e-89
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 324 2e-88
gi|223890235 intracisternal A particle-promoted polypeptide isof... 311 1e-84
gi|45643138 kelch-like 13 [Homo sapiens] 300 3e-81
gi|24308181 kelch-like 9 [Homo sapiens] 300 4e-81
gi|40018614 DRE1 protein [Homo sapiens] 295 8e-80
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 267 2e-71
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens] 267 3e-71
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens] 263 3e-70
gi|55925608 kelch-like 21 [Homo sapiens] 260 3e-69
gi|8922854 kelch-like 26 [Homo sapiens] 260 4e-69
gi|109150407 kelch-like 6 [Homo sapiens] 251 1e-66
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 1551 bits (4015), Expect = 0.0
Identities = 755/755 (100%), Positives = 755/755 (100%)
Query: 1 MNVIYFPLHIFVVYSRAYTSLVLVGCTNLCAVLFARCLDDHLVSLRMSGSRKEFDVKQIL 60
MNVIYFPLHIFVVYSRAYTSLVLVGCTNLCAVLFARCLDDHLVSLRMSGSRKEFDVKQIL
Sbjct: 1 MNVIYFPLHIFVVYSRAYTSLVLVGCTNLCAVLFARCLDDHLVSLRMSGSRKEFDVKQIL 60
Query: 61 KIRWRWFGHQASSPNSTVDSQQGEFWNRGQTGANGGRKFLDPCSLQLPLASIGYRRSSQL 120
KIRWRWFGHQASSPNSTVDSQQGEFWNRGQTGANGGRKFLDPCSLQLPLASIGYRRSSQL
Sbjct: 61 KIRWRWFGHQASSPNSTVDSQQGEFWNRGQTGANGGRKFLDPCSLQLPLASIGYRRSSQL 120
Query: 121 DFQNSPSWPMASTSEVPAFEFTAEDCGGAHWLDRPEVDDGTSEEENESDSSSCRTSNSSQ 180
DFQNSPSWPMASTSEVPAFEFTAEDCGGAHWLDRPEVDDGTSEEENESDSSSCRTSNSSQ
Sbjct: 121 DFQNSPSWPMASTSEVPAFEFTAEDCGGAHWLDRPEVDDGTSEEENESDSSSCRTSNSSQ 180
Query: 181 TLSSCHTMEPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSS 240
TLSSCHTMEPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSS
Sbjct: 181 TLSSCHTMEPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSS 240
Query: 241 VSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLL 300
VSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLL
Sbjct: 241 VSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLL 300
Query: 301 QLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVL 360
QLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVL
Sbjct: 301 QLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVL 360
Query: 361 LPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLA 420
LPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLA
Sbjct: 361 LPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLA 420
Query: 421 DMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKG 480
DMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKG
Sbjct: 421 DMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKG 480
Query: 481 ATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKT 540
ATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKT
Sbjct: 481 ATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKT 540
Query: 541 WSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRST 600
WSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRST
Sbjct: 541 WSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRST 600
Query: 601 VGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAI 660
VGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAI
Sbjct: 601 VGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAI 660
Query: 661 GGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQA 720
GGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQA
Sbjct: 661 GGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQA 720
Query: 721 YLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL 755
YLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL
Sbjct: 721 YLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL 755
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 1458 bits (3774), Expect = 0.0
Identities = 709/709 (100%), Positives = 709/709 (100%)
Query: 47 MSGSRKEFDVKQILKIRWRWFGHQASSPNSTVDSQQGEFWNRGQTGANGGRKFLDPCSLQ 106
MSGSRKEFDVKQILKIRWRWFGHQASSPNSTVDSQQGEFWNRGQTGANGGRKFLDPCSLQ
Sbjct: 1 MSGSRKEFDVKQILKIRWRWFGHQASSPNSTVDSQQGEFWNRGQTGANGGRKFLDPCSLQ 60
Query: 107 LPLASIGYRRSSQLDFQNSPSWPMASTSEVPAFEFTAEDCGGAHWLDRPEVDDGTSEEEN 166
LPLASIGYRRSSQLDFQNSPSWPMASTSEVPAFEFTAEDCGGAHWLDRPEVDDGTSEEEN
Sbjct: 61 LPLASIGYRRSSQLDFQNSPSWPMASTSEVPAFEFTAEDCGGAHWLDRPEVDDGTSEEEN 120
Query: 167 ESDSSSCRTSNSSQTLSSCHTMEPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVA 226
ESDSSSCRTSNSSQTLSSCHTMEPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVA
Sbjct: 121 ESDSSSCRTSNSSQTLSSCHTMEPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVA 180
Query: 227 GDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELK 286
GDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELK
Sbjct: 181 GDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELK 240
Query: 287 EDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTM 346
EDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTM
Sbjct: 241 EDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTM 300
Query: 347 EHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLL 406
EHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLL
Sbjct: 301 EHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLL 360
Query: 407 AYIRLPLLAPQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTV 466
AYIRLPLLAPQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTV
Sbjct: 361 AYIRLPLLAPQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTV 420
Query: 467 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLK 526
GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLK
Sbjct: 421 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLK 480
Query: 527 TLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQAR 586
TLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQAR
Sbjct: 481 TLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQAR 540
Query: 587 QWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRG 646
QWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRG
Sbjct: 541 QWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRG 600
Query: 647 GVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLL 706
GVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLL
Sbjct: 601 GVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLL 660
Query: 707 GDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL 755
GDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL
Sbjct: 661 GDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL 709
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 1384 bits (3581), Expect = 0.0
Identities = 691/755 (91%), Positives = 693/755 (91%), Gaps = 61/755 (8%)
Query: 1 MNVIYFPLHIFVVYSRAYTSLVLVGCTNLCAVLFARCLDDHLVSLRMSGSRKEFDVKQIL 60
MNVIYFPLHIFVVYSRAYTSLVLVGCTNLCAVLFARCLDDHLVSLRMSGSRKEFDVKQIL
Sbjct: 1 MNVIYFPLHIFVVYSRAYTSLVLVGCTNLCAVLFARCLDDHLVSLRMSGSRKEFDVKQIL 60
Query: 61 KIRWRWFGHQASSPNSTVDSQQGEFWNRGQTGANGGRKFLDPCSLQLPLASIGYRRSSQL 120
KIRWRWFGHQASSPNSTVDSQQGEFWNRGQTGANGGRKFLDPCSLQLPLASIGYRRSSQL
Sbjct: 61 KIRWRWFGHQASSPNSTVDSQQGEFWNRGQTGANGGRKFLDPCSLQLPLASIGYRRSSQL 120
Query: 121 DFQNSPSWPMASTSEVPAFEFTAEDCGGAHWLDRPEVDDGTSEEENESDSSSCRTSNSSQ 180
DFQNSPSWPMASTSEVPAFEFTAEDCGGAHWLDRPEVDDGTSEE E++S S
Sbjct: 121 DFQNSPSWPMASTSEVPAFEFTAEDCGGAHWLDRPEVDDGTSEE--ENESDS-------- 170
Query: 181 TLSSCHTMEPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSS 240
SSC RLVLSS
Sbjct: 171 --SSC-------------------------------------------------RLVLSS 179
Query: 241 VSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLL 300
VSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLL
Sbjct: 180 VSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLL 239
Query: 301 QLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVL 360
QLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVL
Sbjct: 240 QLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVL 299
Query: 361 LPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLA 420
LPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLA
Sbjct: 300 LPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLA 359
Query: 421 DMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKG 480
DMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKG
Sbjct: 360 DMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKG 419
Query: 481 ATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKT 540
ATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKT
Sbjct: 420 ATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKT 479
Query: 541 WSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRST 600
WSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRST
Sbjct: 480 WSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRST 539
Query: 601 VGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAI 660
VGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAI
Sbjct: 540 VGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAI 599
Query: 661 GGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQA 720
GGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQA
Sbjct: 600 GGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQA 659
Query: 721 YLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL 755
YLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL
Sbjct: 660 YLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL 694
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 942 bits (2434), Expect = 0.0
Identities = 473/748 (63%), Positives = 568/748 (75%), Gaps = 42/748 (5%)
Query: 47 MSGS-RKEFDVKQILKIRWRWFGHQASSPNSTVDS----QQG----EFWNRGQTGA---- 93
MSGS RK+FDVK IL++RW+ F H + S Q G E W Q+
Sbjct: 1 MSGSGRKDFDVKHILRLRWKLFSHPSPSTGGPAGGGCLQQDGSGSFEHWGPSQSRLLKSQ 60
Query: 94 --NGGRKFLDPCSLQLPLASIGYRRSSQLDFQNSPSWPMASTSE---------------- 135
+G F S +S SS + N P+A+ +
Sbjct: 61 ERSGVSTFWKKPSSSSSSSSSPSSSSSSFNPLNGTLLPVATRLQQGAPGQGTQQPARTLF 120
Query: 136 ---------VPAFEFTAEDCGGAHWLDRPEVDDGTSEEENESDSSSCRTSNSSQTLSSCH 186
VP +F G + D +S+ E R S++ +++
Sbjct: 121 YVESLEEEVVPGMDFPGPHEKGLVLQELKVEPDNSSQATGEGCGH--RLSSTGHSMTPQS 178
Query: 187 TMEPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFA 246
++ +S+EF+QA++HAEQTF+KME+YL+ +QLCDVIL+ G+R+IPAHRLVLSSVSDYFA
Sbjct: 179 DLDSSSSEEFYQAVHHAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFA 238
Query: 247 AMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVV 306
AMFT+DV EA+QEEIKMEG++PN+LW L+Q+AYTG LELKED IE LL+ ACLLQL QVV
Sbjct: 239 AMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVV 298
Query: 307 EACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEI 366
E CC FLMK LHPSNCLGIR+FADAQGC +L KVAH+YTME+ MEVIRNQEF+LLPA E+
Sbjct: 299 EVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEEL 358
Query: 367 AKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADMENNV 426
KLLASDD+N+P+EETI +AL+ WV++D++ R DLS LLA+IRLPLL PQ LAD+EN+
Sbjct: 359 HKLLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILADLENHA 418
Query: 427 LFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEK 486
LF++D+ECQKLI+EAMKYHLLPERR ++QSPRTKPRKSTVGTL+AVGGMD+ KGAT+IEK
Sbjct: 419 LFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATTIEK 478
Query: 487 YDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPP 546
YDLRTN+W MNGRRLQFGVAV+DDKL+V+GGRDGLKTLNTVECYNPKTKTW+V+PP
Sbjct: 479 YDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPP 538
Query: 547 MSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVL 606
MSTHRHGLGV VLEGP+YAVGGHDGWSYLNTVERWDPQ++QW FVA+MS RSTVGVA L
Sbjct: 539 MSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAAL 598
Query: 607 SGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAP 666
+GKLY+VGGRDGSSCL S+E +DPHTNKW +CA M KRRGGVGV T +G LYA+GGHDAP
Sbjct: 599 NGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAP 658
Query: 667 ASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVE 726
ASN SRL D VERYDPKTD WT VA +S+ RDAVGVCLLGD+LYAVGGYDGQ YLNT+E
Sbjct: 659 ASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTME 718
Query: 727 AYDPQTNEWTQVAPLCLGRAGACVVTVK 754
+YDPQTNEWTQ+A L +GRAGACVV +K
Sbjct: 719 SYDPQTNEWTQMASLNIGRAGACVVVIK 746
Score = 76.3 bits (186), Expect = 1e-13
Identities = 41/102 (40%), Positives = 61/102 (59%), Gaps = 6/102 (5%)
Query: 467 GTLFAVGGMDS------TKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVG 520
G L+AVGG D+ ++ +E+YD +T+ WT VA ++ R GV +L D+LY VG
Sbjct: 647 GFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVG 706
Query: 521 GRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGP 562
G DG LNT+E Y+P+T W+ M ++ R G V V++ P
Sbjct: 707 GYDGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVVIKQP 748
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 926 bits (2394), Expect = 0.0
Identities = 463/728 (63%), Positives = 554/728 (76%), Gaps = 39/728 (5%)
Query: 51 RKEFDVKQILKIRWRWFGHQ-ASSPNSTVDSQQGEFWNRG----------QTGANGGRKF 99
+KEFDVKQIL++RWRWF H S N+ QQ + +RG NG +K
Sbjct: 6 KKEFDVKQILRLRWRWFSHPFQGSTNTGSCLQQEGYEHRGTPVQGRLKSHSRDRNGLKKS 65
Query: 100 LDPCSLQL----PLASIGYRRSSQ--------LDFQNSPSWPMASTSEVPAFEFTAEDCG 147
P + P + ++R+ Q + FQ + P + VP E C
Sbjct: 66 NSPVHHNILAPVPGPAPAHQRAVQNLQQHNLIVHFQANEDTPKS----VPEKNLFKEAC- 120
Query: 148 GAHWLDRPEVDDGTSEEENESDSSSCRTSNSSQTLSSCHTMEPCTSDEFFQALNHAEQTF 207
++ D ++N DS++ + S+ +++ S+E F +NHAEQT
Sbjct: 121 -----EKRAQDLEMMADDNIEDSTARLDTQHSEDMNATR------SEEQFHVINHAEQTL 169
Query: 208 KKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVE 267
+KMENYL+ KQLCDV+L+AG RIPAHRLVLS+VSDYFAAMFTNDV EA+QEE++MEGV+
Sbjct: 170 RKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVD 229
Query: 268 PNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRS 327
PN+L SL+QYAYTG L+LKED IE LL+ ACLLQL+QV++ C FL+KQLHPSNCLGIRS
Sbjct: 230 PNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRS 289
Query: 328 FADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNAL 387
F DAQGCT+L VAH YTMEHF+EVI+NQEF+LLPA+EI+KLL SDD+N+P+EETI +AL
Sbjct: 290 FGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHAL 349
Query: 388 LTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADMENNVLFRDDIECQKLIMEAMKYHLL 447
+ WV HD++ R+ +L LL+YIRLPLL PQ LAD+E + +F D+ECQKL+MEAMKYHLL
Sbjct: 350 MQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLL 409
Query: 448 PERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQF 507
PERR M+QSPRTKPRKSTVG L+AVGGMD+ KG T+IEKYDLRTN W + MNGRRLQF
Sbjct: 410 PERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQF 469
Query: 508 GVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVG 567
GVAV+D+KLYVVGGRDGLKTLNTVEC+NP K W+VMPPMSTHRHGLGVA LEGPMYAVG
Sbjct: 470 GVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVG 529
Query: 568 GHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVEC 627
GHDGWSYLNTVERWDP+ RQWN+VA+MSTPRSTVGV L+ KLYA+GGRDGSSCLKS+E
Sbjct: 530 GHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEY 589
Query: 628 FDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDM 687
FDPHTNKW+LCA MSKRRGGVGV T+NG LY +GGHDAPASN SRLSDCVERYDPK D
Sbjct: 590 FDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDS 649
Query: 688 WTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAG 747
W+ VA +S+ RDAV VC LGDKLY VGGYDG YLNTVE+YD Q NEW + P+ +GRAG
Sbjct: 650 WSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAG 709
Query: 748 ACVVTVKL 755
ACVV VKL
Sbjct: 710 ACVVVVKL 717
Score = 65.9 bits (159), Expect = 1e-10
Identities = 51/154 (33%), Positives = 75/154 (48%), Gaps = 19/154 (12%)
Query: 424 NNVLF----RDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTV-----GTLFAVGG 474
NN L+ RD C K +M+Y + L +P +K R G L+ VGG
Sbjct: 569 NNKLYAIGGRDGSSCLK----SMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGG 624
Query: 475 MDS------TKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTL 528
D+ ++ + +E+YD + + W+ VA ++ R V L DKLYVVGG DG L
Sbjct: 625 HDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYL 684
Query: 529 NTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGP 562
NTVE Y+ + W P++ R G V V++ P
Sbjct: 685 NTVESYDAQRNEWKEEVPVNIGRAGACVVVVKLP 718
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 903 bits (2334), Expect = 0.0
Identities = 451/710 (63%), Positives = 540/710 (76%), Gaps = 39/710 (5%)
Query: 51 RKEFDVKQILKIRWRWFGHQ-ASSPNSTVDSQQGEFWNRG----------QTGANGGRKF 99
+KEFDVKQIL++RWRWF H S N+ QQ + +RG NG +K
Sbjct: 6 KKEFDVKQILRLRWRWFSHPFQGSTNTGSCLQQEGYEHRGTPVQGRLKSHSRDRNGLKKS 65
Query: 100 LDPCSLQL----PLASIGYRRSSQ--------LDFQNSPSWPMASTSEVPAFEFTAEDCG 147
P + P + ++R+ Q + FQ + P + VP E C
Sbjct: 66 NSPVHHNILAPVPGPAPAHQRAVQNLQQHNLIVHFQANEDTPKS----VPEKNLFKEAC- 120
Query: 148 GAHWLDRPEVDDGTSEEENESDSSSCRTSNSSQTLSSCHTMEPCTSDEFFQALNHAEQTF 207
++ D ++N DS++ + S+ +++ S+E F +NHAEQT
Sbjct: 121 -----EKRAQDLEMMADDNIEDSTARLDTQHSEDMNATR------SEEQFHVINHAEQTL 169
Query: 208 KKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVE 267
+KMENYL+ KQLCDV+L+AG RIPAHRLVLS+VSDYFAAMFTNDV EA+QEE++MEGV+
Sbjct: 170 RKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVD 229
Query: 268 PNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRS 327
PN+L SL+QYAYTG L+LKED IE LL+ ACLLQL+QV++ C FL+KQLHPSNCLGIRS
Sbjct: 230 PNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRS 289
Query: 328 FADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNAL 387
F DAQGCT+L VAH YTMEHF+EVI+NQEF+LLPA+EI+KLL SDD+N+P+EETI +AL
Sbjct: 290 FGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHAL 349
Query: 388 LTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADMENNVLFRDDIECQKLIMEAMKYHLL 447
+ WV HD++ R+ +L LL+YIRLPLL PQ LAD+E + +F D+ECQKL+MEAMKYHLL
Sbjct: 350 MQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLL 409
Query: 448 PERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQF 507
PERR M+QSPRTKPRKSTVG L+AVGGMD+ KG T+IEKYDLRTN W + MNGRRLQF
Sbjct: 410 PERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQF 469
Query: 508 GVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVG 567
GVAV+D+KLYVVGGRDGLKTLNTVEC+NP K W+VMPPMSTHRHGLGVA LEGPMYAVG
Sbjct: 470 GVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVG 529
Query: 568 GHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVEC 627
GHDGWSYLNTVERWDP+ RQWN+VA+MSTPRSTVGV L+ KLYA+GGRDGSSCLKS+E
Sbjct: 530 GHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEY 589
Query: 628 FDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDM 687
FDPHTNKW+LCA MSKRRGGVGV T+NG LY +GGHDAPASN SRLSDCVERYDPK D
Sbjct: 590 FDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDS 649
Query: 688 WTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQ 737
W+ VA +S+ RDAV VC LGDKLY VGGYDG YLNTVE+YD Q NEW +
Sbjct: 650 WSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKE 699
Score = 168 bits (425), Expect = 2e-41
Identities = 87/192 (45%), Positives = 113/192 (58%), Gaps = 6/192 (3%)
Query: 561 GPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSS 620
G +YAVGG D T+E++D + W + TM+ R GVAV+ KLY VGGRDG
Sbjct: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLK 488
Query: 621 CLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVER 680
L +VECF+P WT+ MS R G+GV T G +YA+GGHD + T VER
Sbjct: 489 TLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNT------VER 542
Query: 681 YDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAP 740
+DP+ W VASMS R VGV L +KLYA+GG DG + L ++E +DP TN+W+ AP
Sbjct: 543 WDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAP 602
Query: 741 LCLGRAGACVVT 752
+ R G V T
Sbjct: 603 MSKRRGGVGVAT 614
Score = 102 bits (253), Expect = 2e-21
Identities = 58/160 (36%), Positives = 84/160 (52%), Gaps = 7/160 (4%)
Query: 594 MSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTW 653
M +PR+ + + G LYAVGG D ++E +D TN W M+ RR GV
Sbjct: 416 MQSPRTKPRKSTV-GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVI 474
Query: 654 NGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAV 713
+ LY +GG D + + VE ++P +WT + MS R +GV L +YAV
Sbjct: 475 DNKLYVVGGRDG------LKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAV 528
Query: 714 GGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTV 753
GG+DG +YLNTVE +DP+ +W VA + R+ VV +
Sbjct: 529 GGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVAL 568
Score = 73.6 bits (179), Expect = 7e-13
Identities = 39/100 (39%), Positives = 56/100 (56%), Gaps = 6/100 (6%)
Query: 655 GLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVG 714
G LYA+GG DA T +E+YD +T+ W + +M+ R GV ++ +KLY VG
Sbjct: 429 GALYAVGGMDAMKGTTT------IEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVG 482
Query: 715 GYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVK 754
G DG LNTVE ++P WT + P+ R G V T++
Sbjct: 483 GRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLE 522
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 508 bits (1309), Expect = e-144
Identities = 254/558 (45%), Positives = 373/558 (66%), Gaps = 10/558 (1%)
Query: 202 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEI 261
H QT + + +H++LCDV+LV G ++I AHR++LS+ S YF AMFT ++ E+RQ E+
Sbjct: 50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEV 109
Query: 262 KMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSN 321
+ ++ ++ LI +AYT ++ ++E N++ LL ACLLQL+++ EACC+FL +QL PSN
Sbjct: 110 VIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSN 169
Query: 322 CLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEE 381
CLGIR+FAD C +L ++A +T +F EV+ ++EF+LLPA+++ +++SD++N+ +EE
Sbjct: 170 CLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEE 229
Query: 382 TILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFL-ADMENNVLFRDDIECQKLIME 440
+ NA++ WV++ +++RR L ++L ++RLPLL+P+FL + ++ L + D EC+ L+ E
Sbjct: 230 QVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDE 289
Query: 441 AMKYHLLPERRPMLQSPRTKPRK--STVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVA 498
A Y LLP+ RP++Q PRT+PRK LFAVGG S +S+E+YD +TN W VA
Sbjct: 290 AKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVA 349
Query: 499 NMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSV-MPPMSTHRHGLGVA 557
+M+ RR GV+VLDD LY VGG DG LN+VE Y+PKT WS + P ST R +GVA
Sbjct: 350 SMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVA 409
Query: 558 VLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRD 617
VL G +YAVGG DG S LN VER+DP+ +W VA+MST R V VAVL G LYAVGG D
Sbjct: 410 VLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSD 469
Query: 618 GSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDC 677
G+S L +VE ++P N+W A M RR +G + ++YA+GG D T+ LS
Sbjct: 470 GTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDD-----TTELSS- 523
Query: 678 VERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQ 737
ERY+P+T+ W+ V +M+ R VG+ ++ +L AVGG+DG YL T+E +DP N W
Sbjct: 524 AERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRL 583
Query: 738 VAPLCLGRAGACVVTVKL 755
+ R G V +K+
Sbjct: 584 YGGMNYRRLGGGVGVIKM 601
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 474 bits (1220), Expect = e-133
Identities = 247/557 (44%), Positives = 346/557 (62%), Gaps = 9/557 (1%)
Query: 202 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEI 261
H F M + LCD++L + I AH++VL+S S YF AMFTN++ E+RQ +
Sbjct: 74 HYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHV 133
Query: 262 KMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSN 321
+ ++P +L L+Q+AYT + + E N++ LL A LLQL+ V +ACCKFL+ QL PSN
Sbjct: 134 TLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSN 193
Query: 322 CLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEE 381
CLGIR FADA C+DL K AH Y ++HF++V + +EF+LLP ++ +L++SD +N+P+EE
Sbjct: 194 CLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEE 253
Query: 382 TILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQF-LADMENNVLFRDDIECQKLIME 440
+ A+L+WV+HD++ RR+ + +L+ +RLPLL+ F L ++ L R +C+ L++E
Sbjct: 254 EVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIE 313
Query: 441 AMKYHLLPERRPMLQSPRTKPRK--STVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVA 498
A+K+HLLPE+R +L + RT+PR+ LFAVGG E YD RT+ W VA
Sbjct: 314 ALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVVA 373
Query: 499 NMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAV 558
+M+ RR + GVA + ++LY VGG DG L TVE Y+P T TW M T R LGVA
Sbjct: 374 SMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAA 433
Query: 559 LEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDG 618
L G +Y+ GG+DG S LN+ ER+DP W VA MST R V VA L G LYAVGG D
Sbjct: 434 LHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDS 493
Query: 619 SSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCV 678
SS L +VE ++P N W+ A M RR GV G LY GG+D TS L+ V
Sbjct: 494 SSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDG-----TSCLNS-V 547
Query: 679 ERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQV 738
ERY PK W +VA M+I R + + LYAVGG DG + LN++E Y+P+TN+W
Sbjct: 548 ERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAA 607
Query: 739 APLCLGRAGACVVTVKL 755
+ + R+ V ++L
Sbjct: 608 SCMFTRRSSVGVAVLEL 624
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 439 bits (1128), Expect = e-123
Identities = 232/558 (41%), Positives = 343/558 (61%), Gaps = 12/558 (2%)
Query: 202 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEI 261
H ++ FK M LCDV +VA D I AHR+VL++ S YF AMFT ++ E+R + +
Sbjct: 42 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 101
Query: 262 KMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSN 321
+++ V+ +L LI Y YT +++ E+N++ LL A LLQL V + CC+FL QLHP N
Sbjct: 102 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 161
Query: 322 CLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEE 381
CLGIR+FAD CTDL A+ Y +HF +V+ ++EF+ L ++ L++SD + I +EE
Sbjct: 162 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 221
Query: 382 TILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIECQKLIME 440
+ A++ WV HD + R++ +++L+ ++RLPLL ++L +E L ++ C+ ++E
Sbjct: 222 KVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIE 281
Query: 441 AMKYHLLP-ERRPMLQSPRTKPR-KSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVA 498
AMKYHLLP E+R +++S RT+ R + L V G + K S+E YD + W VA
Sbjct: 282 AMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVA 341
Query: 499 NMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAV 558
+ RR + G+ + ++ VGG +G + TV+ Y+P W+ + M R LG AV
Sbjct: 342 ELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAV 401
Query: 559 LEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDG 618
L G +YAVGG DG + L++VE ++ ++ +W VA M+T RS+VGV V+ G LYAVGG DG
Sbjct: 402 LNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDG 461
Query: 619 SS--CLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSD 676
+S CL +VEC++ TN+WT A+MS RR G GV N LLYA+GGHD P +
Sbjct: 462 ASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL------VRK 515
Query: 677 CVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWT 736
VE YDP T+ W VA M++ R GVC + LY VGG DG L +VE Y+P T++WT
Sbjct: 516 SVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWT 575
Query: 737 QVAP-LCLGRAGACVVTV 753
V+ + GR+ A V +
Sbjct: 576 VVSSCMSTGRSYAGVTVI 593
Score = 35.8 bits (81), Expect = 0.15
Identities = 20/51 (39%), Positives = 29/51 (56%), Gaps = 1/51 (1%)
Query: 467 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVAN-MNGRRLQFGVAVLDDKL 516
G L+ VGG D + S+E Y+ T+ WT V++ M+ R GV V+D L
Sbjct: 547 GLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL 597
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 439 bits (1128), Expect = e-123
Identities = 232/558 (41%), Positives = 343/558 (61%), Gaps = 12/558 (2%)
Query: 202 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEI 261
H ++ FK M LCDV +VA D I AHR+VL++ S YF AMFT ++ E+R + +
Sbjct: 38 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 97
Query: 262 KMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSN 321
+++ V+ +L LI Y YT +++ E+N++ LL A LLQL V + CC+FL QLHP N
Sbjct: 98 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 157
Query: 322 CLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEE 381
CLGIR+FAD CTDL A+ Y +HF +V+ ++EF+ L ++ L++SD + I +EE
Sbjct: 158 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 217
Query: 382 TILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIECQKLIME 440
+ A++ WV HD + R++ +++L+ ++RLPLL ++L +E L ++ C+ ++E
Sbjct: 218 KVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIE 277
Query: 441 AMKYHLLP-ERRPMLQSPRTKPR-KSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVA 498
AMKYHLLP E+R +++S RT+ R + L V G + K S+E YD + W VA
Sbjct: 278 AMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVA 337
Query: 499 NMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAV 558
+ RR + G+ + ++ VGG +G + TV+ Y+P W+ + M R LG AV
Sbjct: 338 ELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAV 397
Query: 559 LEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDG 618
L G +YAVGG DG + L++VE ++ ++ +W VA M+T RS+VGV V+ G LYAVGG DG
Sbjct: 398 LNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDG 457
Query: 619 SS--CLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSD 676
+S CL +VEC++ TN+WT A+MS RR G GV N LLYA+GGHD P +
Sbjct: 458 ASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL------VRK 511
Query: 677 CVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWT 736
VE YDP T+ W VA M++ R GVC + LY VGG DG L +VE Y+P T++WT
Sbjct: 512 SVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWT 571
Query: 737 QVAP-LCLGRAGACVVTV 753
V+ + GR+ A V +
Sbjct: 572 VVSSCMSTGRSYAGVTVI 589
Score = 35.8 bits (81), Expect = 0.15
Identities = 20/51 (39%), Positives = 29/51 (56%), Gaps = 1/51 (1%)
Query: 467 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVAN-MNGRRLQFGVAVLDDKL 516
G L+ VGG D + S+E Y+ T+ WT V++ M+ R GV V+D L
Sbjct: 543 GLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL 593
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 438 bits (1126), Expect = e-122
Identities = 238/560 (42%), Positives = 345/560 (61%), Gaps = 16/560 (2%)
Query: 202 HAEQTFKKMENYLRHKQL-CDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEE 260
H + FK M N LR KQL CDV++VA D I AHR+VL++ S YF AMFT D+ E++ ++
Sbjct: 32 HMGKAFKVM-NELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKK 90
Query: 261 IKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPS 320
I+++ V+ +L LI Y YT +E+ E+N++ LL A LLQL V + CC FL QLHP+
Sbjct: 91 IEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPT 150
Query: 321 NCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNE 380
NCLGIR+FAD CTDL + A+ Y +HF EV+ +EF+ L ++ L++SD + + +E
Sbjct: 151 NCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSE 210
Query: 381 ETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIECQKLIM 439
E + A+++W+ ++ E R + ++KL+ ++RLPLL +L +E L +++ C+ ++
Sbjct: 211 EKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLI 270
Query: 440 EAMKYHLLP-ERRPMLQSPRTKPRK--STVGTLFAVGGMDSTKGATSIEKYDLRTNMWTP 496
EAMKYHLLP ++R ++++PRTKPR S + VGG + K S+E YD + W
Sbjct: 271 EAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGG-QAPKAIRSVECYDFEEDRWDQ 329
Query: 497 VANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGV 556
+A + RR + GV + +Y VGG +G + TV+ Y+ W+ + M R LG
Sbjct: 330 IAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGA 389
Query: 557 AVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGR 616
AVL +YAVGG DG + L +VE + + +W FVA M+T RS+VGV V+ GKLYAVGG
Sbjct: 390 AVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGY 449
Query: 617 DGSS--CLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRL 674
DG+S CL +VE ++P TN+W A MS RR G GV +G LYA GGHD P +
Sbjct: 450 DGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPL------V 503
Query: 675 SDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNE 734
VE YDP T+ W VA M++ R GVC + LY VGG DG L +VE Y+P T++
Sbjct: 504 RKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDK 563
Query: 735 WTQV-APLCLGRAGACVVTV 753
WT + + GR+ A V +
Sbjct: 564 WTLLPTNMSTGRSYAGVAVI 583
Score = 102 bits (254), Expect = 1e-21
Identities = 59/161 (36%), Positives = 83/161 (51%), Gaps = 6/161 (3%)
Query: 594 MSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTW 653
+ PR+ V K+ V G ++SVEC+D ++W A++ RR GV
Sbjct: 286 IKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFM 345
Query: 654 NGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAV 713
G +YA+GG + T V+ YD D WT++ASM R +G +L D LYAV
Sbjct: 346 AGHVYAVGGFNGSLRVRT------VDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAV 399
Query: 714 GGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVK 754
GG+DG L +VEAY +TNEW VAP+ R+ V V+
Sbjct: 400 GGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVE 440
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 435 bits (1118), Expect = e-122
Identities = 225/550 (40%), Positives = 331/550 (60%), Gaps = 10/550 (1%)
Query: 210 MENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPN 269
ME R +LCDV L GD + AHR+VL++ YF AMFTND+ E +Q+EI M+G++P+
Sbjct: 28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPS 87
Query: 270 SLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFA 329
+L +LI +AY G L + + N++ LL A LQL + +ACC FL ++LHP NCLG+R FA
Sbjct: 88 ALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFA 147
Query: 330 DAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLT 389
+ C L+ A+++ +HF+EV ++EF+ LP ++ +L++ D++N+ +EE + A L
Sbjct: 148 ETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALA 207
Query: 390 WVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIECQKLIMEAMKYHLLP 448
WVR+D EQR L +LL+ IRLPL PQFL+D ++ + L R +C+ L+ EA YHL+P
Sbjct: 208 WVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMP 267
Query: 449 ERRPMLQSPRTKPR--KSTVGTLFAVGGMDSTKGATS-IEKYDLRTNMWTPVANMNGRRL 505
ERRP L + RT+PR S G ++AVGG++S + + +E +D N W M R
Sbjct: 268 ERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARS 327
Query: 506 QFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYA 565
+ GVAV++ LY +GG DG L+TVE YNP+T TW+ + M++ R +G VL+G +Y
Sbjct: 328 RVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYV 387
Query: 566 VGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSV 625
GG+DG S L++VE + P+ +W V +MS+ RS GV V G++Y GG DG SV
Sbjct: 388 CGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSV 447
Query: 626 ECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKT 685
E ++ HT W A M +R G + ++ GG+D S E Y
Sbjct: 448 EHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDG------SGFLSIAEMYSSVA 501
Query: 686 DMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGR 745
D W + M R V + +LYAVGGYDGQ+ L++VE YDP+T+ WT +AP+
Sbjct: 502 DQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPMACHE 561
Query: 746 AGACVVTVKL 755
G V + L
Sbjct: 562 GGVGVGCIPL 571
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 420 bits (1079), Expect = e-117
Identities = 222/553 (40%), Positives = 339/553 (61%), Gaps = 27/553 (4%)
Query: 202 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEI 261
H+EQ + + +H +LCD+IL GD +I AH++VL+SVS YF AMFT ++ E E+
Sbjct: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEV 76
Query: 262 KMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSN 321
+ + ++ +L ++++YAYTG + + +D +E LL A LLQ+ V++ CC FL QL P N
Sbjct: 77 EFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGN 136
Query: 322 CLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEE 381
C+GI FA+ GC DL+ A Y ++F V + +EF L +++ +++++D +N+ EE
Sbjct: 137 CIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEE 196
Query: 382 TILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADM-ENNVLFRDDIECQKLIME 440
T+ AL +W+++D+++R+K L++LL +RLPLL+ +FL + E N L RDD C+ L+ E
Sbjct: 197 TVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNE 256
Query: 441 AMKYHLLPERR-----PMLQSPRTKPRKSTVGTLFAVGGMDSTKGA-TSIEKYDLRTNMW 494
A+KYH +PE R ++ PR P+ L AVGG S+E Y + + W
Sbjct: 257 ALKYHFMPEHRLSHQTVLMTRPRCAPK-----VLCAVGGKSGLFACLDSVEMYFPQNDSW 311
Query: 495 TPVANMNGRRLQFGVAVLDDKLYVVGG-----RDGL---KTLNTVECYNPKTKTWSVMPP 546
+A +N R +FG+ VLD K+YV+GG R G+ K N+VEC+NP T TW+ +
Sbjct: 312 IGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLER 371
Query: 547 MSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVL 606
M+ R LGV VL G +YA+GG+DG SYL +VE++ P+ R+W VA M+T RS AVL
Sbjct: 372 MNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVL 431
Query: 607 SGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAP 666
G +YA+GG G + + SVE +DP + W + A M+ +R GV G ++ +GGH+
Sbjct: 432 DGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNG- 489
Query: 667 ASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVE 726
S+L+S +ERYDP + WT M R VG ++ + LY VGG+ G +YLNTV+
Sbjct: 490 VSHLSS-----IERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQ 544
Query: 727 AYDPQTNEWTQVA 739
YDP ++ W A
Sbjct: 545 KYDPISDTWLDSA 557
Score = 142 bits (357), Expect = 1e-33
Identities = 75/185 (40%), Positives = 105/185 (56%), Gaps = 1/185 (0%)
Query: 467 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLK 526
G L+A+GG D S+EKY + W PVA M R F AVLD +Y +GG G
Sbjct: 386 GELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGY-GPA 444
Query: 527 TLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQAR 586
+N+VE Y+P +W ++ M+ R GV V+ G ++ VGGH+G S+L+++ER+DP
Sbjct: 445 HMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPHQN 504
Query: 587 QWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRG 646
QW M PR+ VG AV+ LY VGG GSS L +V+ +DP ++ W A M R
Sbjct: 505 QWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGMIYCRC 564
Query: 647 GVGVT 651
G+T
Sbjct: 565 NFGLT 569
Score = 110 bits (274), Expect = 6e-24
Identities = 55/140 (39%), Positives = 83/140 (59%), Gaps = 1/140 (0%)
Query: 467 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLK 526
G ++A+GG S+E+YD + W VA+M +R+ FGV V+ ++VVGG +G+
Sbjct: 433 GMIYAIGGYGPAH-MNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVS 491
Query: 527 TLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQAR 586
L+++E Y+P W+V PM R G+G AV++ +Y VGGH G SYLNTV+++DP +
Sbjct: 492 HLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISD 551
Query: 587 QWNFVATMSTPRSTVGVAVL 606
W A M R G+ L
Sbjct: 552 TWLDSAGMIYCRCNFGLTAL 571
Score = 95.9 bits (237), Expect = 1e-19
Identities = 60/170 (35%), Positives = 93/170 (54%), Gaps = 15/170 (8%)
Query: 583 PQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGS-SCLKSVECFDPHTNKWTLCAQM 641
P+ R + M+ PR V L AVGG+ G +CL SVE + P + W A +
Sbjct: 264 PEHRLSHQTVLMTRPRCAPKV------LCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPL 317
Query: 642 SKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLS-----DCVERYDPKTDMWTAVASMSI 696
+ R G+ + +Y IGG A+N+ ++ + VE ++P T+ WT++ M+
Sbjct: 318 NIPRYEFGICVLDQKVYVIGGI---ATNVRPGVTIRKHENSVECWNPDTNTWTSLERMNE 374
Query: 697 SRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRA 746
SR +GV +L +LYA+GGYDGQ+YL +VE Y P+ +W VAP+ R+
Sbjct: 375 SRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRS 424
Score = 70.1 bits (170), Expect = 7e-12
Identities = 38/94 (40%), Positives = 49/94 (52%)
Query: 466 VGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGL 525
+G +F VGG + +SIE+YD N WT M R G AV+D+ LYVVGG G
Sbjct: 478 LGFIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGS 537
Query: 526 KTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVL 559
LNTV+ Y+P + TW M R G+ L
Sbjct: 538 SYLNTVQKYDPISDTWLDSAGMIYCRCNFGLTAL 571
Score = 55.5 bits (132), Expect = 2e-07
Identities = 33/106 (31%), Positives = 52/106 (49%), Gaps = 13/106 (12%)
Query: 656 LLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGG 715
+L A+GG + L D VE Y P+ D W +A ++I R G+C+L K+Y +GG
Sbjct: 284 VLCAVGGKSGLFACL-----DSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGG 338
Query: 716 YDGQA--------YLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTV 753
+ N+VE ++P TN WT + + R+ VV +
Sbjct: 339 IATNVRPGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVL 384
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 416 bits (1070), Expect = e-116
Identities = 226/565 (40%), Positives = 331/565 (58%), Gaps = 16/565 (2%)
Query: 194 DEFFQALNHAEQTFK-KMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTND 252
D F N A + F + + + +LCDV L G + I H+LVL+ V YF AMF ++
Sbjct: 40 DSFIFEANEAWKDFHGSLLRFYENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSE 99
Query: 253 VREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKF 312
+ EA+Q I++ + +++ L+++ Y+ RL L DN++ LL AC+LQ+ V ACC++
Sbjct: 100 MAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEY 159
Query: 313 LMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLAS 372
+ HPSNCL +R+FA++ DL +A Y +HF EV+ ++FV + + KLL+S
Sbjct: 160 MKLHFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSS 219
Query: 373 DDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDD 431
D+NI NE+ + NA + W+ + + K L + LA +RLPLL FL + + + +
Sbjct: 220 SDLNIENEKQVYNAAIKWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQN 279
Query: 432 IECQKLIMEAMKYHLLPERRPMLQ---SPRTKPRKSTVGTLFAVGGM-DSTKGATSIEKY 487
++C+ L+ EA YHL R + S RT PRK T G LF VGG S SIE Y
Sbjct: 280 LKCRDLLDEARNYHLHLSSRAVPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECY 339
Query: 488 DLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPM 547
+ N W MN RR GV ++ K+Y VGG DG + L ++E ++P T W + M
Sbjct: 340 SINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASM 399
Query: 548 STHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLS 607
+T R G+ +A L GP+YA+GG D + N VER+D ++ QW+ VA M+TPR VG L
Sbjct: 400 NTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALV 459
Query: 608 GKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHD--A 665
+YAVGG DG + L SVE +DPH +KW +M +RR G GV+ +G LY +GG D +
Sbjct: 460 NHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNS 519
Query: 666 PASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTV 725
P S+ VERYDP+++ W VA+++ R VG+ + K++AVGG++G AYLNTV
Sbjct: 520 PLSS--------VERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTV 571
Query: 726 EAYDPQTNEWTQVAPLCLGRAGACV 750
EA+DP N W V + RAGA V
Sbjct: 572 EAFDPVLNRWELVGSVSHCRAGAGV 596
Score = 119 bits (297), Expect = 1e-26
Identities = 60/142 (42%), Positives = 87/142 (61%)
Query: 466 VGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGL 525
V ++AVGG D +S+E+YD + W V M RR GV+ L LYVVGG D
Sbjct: 459 VNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDN 518
Query: 526 KTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQA 585
L++VE Y+P++ W + ++T R G+G+A + G ++AVGGH+G +YLNTVE +DP
Sbjct: 519 SPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVL 578
Query: 586 RQWNFVATMSTPRSTVGVAVLS 607
+W V ++S R+ GVAV S
Sbjct: 579 NRWELVGSVSHCRAGAGVAVCS 600
Score = 32.3 bits (72), Expect = 1.7
Identities = 21/59 (35%), Positives = 31/59 (52%), Gaps = 1/59 (1%)
Query: 454 LQSPRTKPRKSTV-GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAV 511
L +PR +TV G +FAVGG + ++E +D N W V +++ R GVAV
Sbjct: 540 LTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAV 598
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 415 bits (1067), Expect = e-116
Identities = 213/560 (38%), Positives = 323/560 (57%), Gaps = 13/560 (2%)
Query: 202 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEI 261
HA+ M + + LCDV L + PAHR+VL++ SDYF AMFT+++ E + +
Sbjct: 15 HAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYV 74
Query: 262 KMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSN 321
++G+ +++ L+ + YT + + +N++ LL ACLLQL V +ACC+FL QL PSN
Sbjct: 75 DIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSN 134
Query: 322 CLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEE 381
CLGIR FA+ C DL + A ++ +HF EV++++EF+LL E+ KL+ D++ + +EE
Sbjct: 135 CLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEE 194
Query: 382 TILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIECQKLIME 440
+ A++ WV+H ++R + L LL Y+R+PLL P+++ D ++ R ++C+ L+ E
Sbjct: 195 PVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDE 254
Query: 441 AMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATS-IEKYDLRTNMWTPVAN 499
A K+HL PE R +Q PRT+ R L VGG S + +EKYD +T W+ + +
Sbjct: 255 AKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPS 314
Query: 500 MNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYN---PKTKTWSVMPPMSTHRHGLGV 556
+ +R L D++YV+GG DG L++VEC + + W + PM+ R G
Sbjct: 315 ITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGA 374
Query: 557 AVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGR 616
L +Y GG DG ++ER+DP QW+ + M T R G+ V SG +Y +GG
Sbjct: 375 TTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGY 434
Query: 617 DGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSD 676
DG + L SVE +DPHT WT M+ +R G GV N +Y +GG D T+ LS
Sbjct: 435 DGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDG-----TAHLSS 489
Query: 677 CVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWT 736
VE Y+ +TD WT V SM+ R VG +L +LYA+ GYDG + L+++E YDP + W
Sbjct: 490 -VEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWE 548
Query: 737 QVAPLCLGR--AGACVVTVK 754
V + R AG CV+ K
Sbjct: 549 VVTSMGTQRCDAGVCVLREK 568
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 393 bits (1010), Expect = e-109
Identities = 208/505 (41%), Positives = 311/505 (61%), Gaps = 12/505 (2%)
Query: 255 EARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLM 314
E+R + ++++ V+ +L LI Y YT +++ E+N++ LL A LLQL V + CC+FL
Sbjct: 3 ESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLE 62
Query: 315 KQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDD 374
QLHP NCLGIR+FAD CTDL A+ Y +HF +V+ ++EF+ L ++ L++SD
Sbjct: 63 SQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDK 122
Query: 375 MNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIE 433
+ I +EE + A++ WV HD + R++ +++L+ ++RLPLL ++L +E L ++
Sbjct: 123 LTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSA 182
Query: 434 CQKLIMEAMKYHLLP-ERRPMLQSPRTKPR-KSTVGTLFAVGGMDSTKGATSIEKYDLRT 491
C+ ++EAMKYHLLP E+R +++S RT+ R + L V G + K S+E YD +
Sbjct: 183 CKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKE 242
Query: 492 NMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHR 551
W VA + RR + G+ + ++ VGG +G + TV+ Y+P W+ + M R
Sbjct: 243 ERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRR 302
Query: 552 HGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLY 611
LG AVL G +YAVGG DG + L++VE ++ ++ +W VA M+T RS+VGV V+ G LY
Sbjct: 303 STLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLY 362
Query: 612 AVGGRDGSS--CLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASN 669
AVGG DG+S CL +VEC++ TN+WT A+MS RR G GV N LLYA+GGHD P
Sbjct: 363 AVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL-- 420
Query: 670 LTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYD 729
+ VE YDP T+ W VA M++ R GVC + LY VGG DG L +VE Y+
Sbjct: 421 ----VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYN 476
Query: 730 PQTNEWTQVAP-LCLGRAGACVVTV 753
P T++WT V+ + GR+ A V +
Sbjct: 477 PTTDKWTVVSSCMSTGRSYAGVTVI 501
Score = 35.8 bits (81), Expect = 0.15
Identities = 20/51 (39%), Positives = 29/51 (56%), Gaps = 1/51 (1%)
Query: 467 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVAN-MNGRRLQFGVAVLDDKL 516
G L+ VGG D + S+E Y+ T+ WT V++ M+ R GV V+D L
Sbjct: 455 GLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL 505
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 368 bits (945), Expect = e-101
Identities = 207/560 (36%), Positives = 311/560 (55%), Gaps = 21/560 (3%)
Query: 201 NHAEQTFKKMENYLRHKQLCDVILVAGDRRIPA-----HRLVLSSVSDYFAAMFTNDVRE 255
+H +Q F M +QLCDV L + PA H++VL+S S F AMFTN +RE
Sbjct: 58 DHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLRE 117
Query: 256 ARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMK 315
E + +EG+ P + LI++AYT + + E + +++ A + Q+ VV AC FL++
Sbjct: 118 QGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQ 177
Query: 316 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDM 375
QL PSN +GI +FA+ GC +LH+ A Y HF EV + +EF L ++ L++ DD+
Sbjct: 178 QLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDL 237
Query: 376 NIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFL-ADMENNVLFRDDIEC 434
N+ E + +A + WV++D EQRR + LL +R L P FL ++ + + D C
Sbjct: 238 NVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRC 297
Query: 435 QKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMW 494
+ +++ + L +P P P+ VG L G + + +E Y+ W
Sbjct: 298 KDYLVKI--FEELTLHKPTQVMPCRAPK---VGRLIYTAGGYFRQSLSYLEAYNPSDGTW 352
Query: 495 TPVANMNGRRLQFGVAVLDDKLYVVGGR----DGLKTLNTVECYNPKTKTWSVMPPMSTH 550
+A++ R V+ LY VGGR DG + ++CYNP T WS PMS
Sbjct: 353 LRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVP 412
Query: 551 RHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKL 610
R+ +GV V++G +YAVGG G + N+VER++P+ +W+ VA M T R VGVAVL+ L
Sbjct: 413 RNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLL 472
Query: 611 YAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNL 670
YAVGG DG++ L S EC+ P N+W + M+ R G GV + +YA GG+D L
Sbjct: 473 YAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDG-QDQL 531
Query: 671 TSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDP 730
S VERYD +T+ WT VA M R A+G+ + ++Y +GGYDG +L++VE YDP
Sbjct: 532 NS-----VERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDP 586
Query: 731 QTNEWTQVAPLCLGRAGACV 750
T+ W++V + GR+G V
Sbjct: 587 DTDTWSEVTRMTSGRSGVGV 606
Score = 94.4 bits (233), Expect = 4e-19
Identities = 52/145 (35%), Positives = 78/145 (53%), Gaps = 5/145 (3%)
Query: 610 LYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGG-HDAPAS 668
+Y GG S L +E ++P W A + R G+ GLLYA+GG +++P
Sbjct: 328 IYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
Query: 669 NLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAY 728
N S DC Y+P T+ W+ A MS+ R+ +GV ++ +YAVGG G + N+VE Y
Sbjct: 387 NTDSSALDC---YNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERY 443
Query: 729 DPQTNEWTQVAPLCLGRAGACVVTV 753
+P+ +EW VAP+ R G V +
Sbjct: 444 EPERDEWHLVAPMLTRRIGVGVAVL 468
Score = 87.8 bits (216), Expect = 3e-17
Identities = 42/94 (44%), Positives = 58/94 (61%)
Query: 469 LFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTL 528
++A GG D S+E+YD+ T WT VA M RR G+ V ++YV+GG DG L
Sbjct: 519 IYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFL 578
Query: 529 NTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGP 562
++VECY+P T TWS + M++ R G+GVAV P
Sbjct: 579 DSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEP 612
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 368 bits (945), Expect = e-101
Identities = 207/560 (36%), Positives = 311/560 (55%), Gaps = 21/560 (3%)
Query: 201 NHAEQTFKKMENYLRHKQLCDVILVAGDRRIPA-----HRLVLSSVSDYFAAMFTNDVRE 255
+H +Q F M +QLCDV L + PA H++VL+S S F AMFTN +RE
Sbjct: 58 DHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLRE 117
Query: 256 ARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMK 315
E + +EG+ P + LI++AYT + + E + +++ A + Q+ VV AC FL++
Sbjct: 118 QGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQ 177
Query: 316 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDM 375
QL PSN +GI +FA+ GC +LH+ A Y HF EV + +EF L ++ L++ DD+
Sbjct: 178 QLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDL 237
Query: 376 NIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFL-ADMENNVLFRDDIEC 434
N+ E + +A + WV++D EQRR + LL +R L P FL ++ + + D C
Sbjct: 238 NVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRC 297
Query: 435 QKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMW 494
+ +++ + L +P P P+ VG L G + + +E Y+ W
Sbjct: 298 KDYLVKI--FEELTLHKPTQVMPCRAPK---VGRLIYTAGGYFRQSLSYLEAYNPSDGTW 352
Query: 495 TPVANMNGRRLQFGVAVLDDKLYVVGGR----DGLKTLNTVECYNPKTKTWSVMPPMSTH 550
+A++ R V+ LY VGGR DG + ++CYNP T WS PMS
Sbjct: 353 LRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVP 412
Query: 551 RHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKL 610
R+ +GV V++G +YAVGG G + N+VER++P+ +W+ VA M T R VGVAVL+ L
Sbjct: 413 RNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLL 472
Query: 611 YAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNL 670
YAVGG DG++ L S EC+ P N+W + M+ R G GV + +YA GG+D L
Sbjct: 473 YAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDG-QDQL 531
Query: 671 TSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDP 730
S VERYD +T+ WT VA M R A+G+ + ++Y +GGYDG +L++VE YDP
Sbjct: 532 NS-----VERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDP 586
Query: 731 QTNEWTQVAPLCLGRAGACV 750
T+ W++V + GR+G V
Sbjct: 587 DTDTWSEVTRMTSGRSGVGV 606
Score = 94.4 bits (233), Expect = 4e-19
Identities = 52/145 (35%), Positives = 78/145 (53%), Gaps = 5/145 (3%)
Query: 610 LYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGG-HDAPAS 668
+Y GG S L +E ++P W A + R G+ GLLYA+GG +++P
Sbjct: 328 IYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
Query: 669 NLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAY 728
N S DC Y+P T+ W+ A MS+ R+ +GV ++ +YAVGG G + N+VE Y
Sbjct: 387 NTDSSALDC---YNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERY 443
Query: 729 DPQTNEWTQVAPLCLGRAGACVVTV 753
+P+ +EW VAP+ R G V +
Sbjct: 444 EPERDEWHLVAPMLTRRIGVGVAVL 468
Score = 87.8 bits (216), Expect = 3e-17
Identities = 42/94 (44%), Positives = 58/94 (61%)
Query: 469 LFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTL 528
++A GG D S+E+YD+ T WT VA M RR G+ V ++YV+GG DG L
Sbjct: 519 IYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFL 578
Query: 529 NTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGP 562
++VECY+P T TWS + M++ R G+GVAV P
Sbjct: 579 DSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEP 612
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 328 bits (840), Expect = 1e-89
Identities = 178/543 (32%), Positives = 292/543 (53%), Gaps = 16/543 (2%)
Query: 218 QLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQY 277
+LCDV++ AH+ +L S S YF A+FT+ ++ + G+ P+ + +I+Y
Sbjct: 37 KLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEY 96
Query: 278 AYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDL 337
AYT + + DN+E LL+ A + +V CC+FL +L NC+GI F D C +L
Sbjct: 97 AYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPEL 156
Query: 338 HKVAHNYTMEHFMEVIR-NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLE 396
+ A+ + + +F E+++ + EF+ L +E+ ++ D++N+ E+ + A+L W+ HD +
Sbjct: 157 RQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQ 216
Query: 397 QRRKDLSKLLAYIRLPLL-APQFLADMENNVLFRDDIECQKLIMEAMK----YHLLPERR 451
R++ +S LL +RL L+ A F+ +++ N +D EC+ +I+ A+K ++
Sbjct: 217 NRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMYDLNMNGPSN 276
Query: 452 PMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVA-NMNGRRLQFGVA 510
+P T+PR LFA+GG +IE YD R + W V R G A
Sbjct: 277 SDFTNPLTRPRLP-YAILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAA 335
Query: 511 VLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHD 570
L +Y++GG D + N+V+ ++P KTW + PM + R + V VL +YA+GG D
Sbjct: 336 YLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFD 395
Query: 571 GWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDP 630
G+ LNT ER++P+ QW +A M RS L GK+Y GG +G+ CL + E ++
Sbjct: 396 GYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNT 455
Query: 631 HTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTA 690
+N+WT+ A M RR G+GV + +YA+GG D A+ L S E Y P + W
Sbjct: 456 ESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDG-ANRLRS-----AEAYSPVANTWRT 509
Query: 691 VASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRA--GA 748
+ +M R G+ ++ D L+ VGG++G VE YD +T+EW + + R+
Sbjct: 510 IPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSC 569
Query: 749 CVV 751
CVV
Sbjct: 570 CVV 572
Score = 131 bits (330), Expect = 2e-30
Identities = 67/188 (35%), Positives = 101/188 (53%)
Query: 469 LFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTL 528
++A+GG D + E+Y+ TN WT +A M+ +R L K+Y+ GG +G + L
Sbjct: 388 IYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECL 447
Query: 529 NTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQW 588
T E YN ++ W+V+ PM + R G+GV +YAVGG DG + L + E + P A W
Sbjct: 448 FTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTW 507
Query: 589 NFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGV 648
+ TM PRS G+ V+ L+ VGG +G + +VEC+D T++W MS R +
Sbjct: 508 RTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSAL 567
Query: 649 GVTTWNGL 656
GL
Sbjct: 568 SCCVVPGL 575
Score = 94.7 bits (234), Expect = 3e-19
Identities = 51/145 (35%), Positives = 77/145 (53%), Gaps = 7/145 (4%)
Query: 610 LYAVGGRDGSSCLKSVECFDPHTNKWT-LCAQMSKRRGGVGVTTWNGLLYAIGGHDAPAS 668
L+A+GG G S ++E +D ++W + + R G G +Y IGG D+
Sbjct: 293 LFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVD- 351
Query: 669 NLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAY 728
+ V+R+DP W VA M R V V +LG+ +YA+GG+DG LNT E Y
Sbjct: 352 -----YFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERY 406
Query: 729 DPQTNEWTQVAPLCLGRAGACVVTV 753
+P+TN+WT +AP+ R+ A T+
Sbjct: 407 EPETNQWTLIAPMHEQRSDASATTL 431
Score = 92.4 bits (228), Expect = 1e-18
Identities = 47/157 (29%), Positives = 75/157 (47%)
Query: 452 PMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAV 511
PM + + G ++ GG + + + E Y+ +N WT +A M RR GV
Sbjct: 418 PMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIA 477
Query: 512 LDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDG 571
+ +Y VGG DG L + E Y+P TW +P M R G+ V++ ++ VGG +G
Sbjct: 478 YGEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNG 537
Query: 572 WSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSG 608
++ VE +D + +W MS RS + V+ G
Sbjct: 538 FTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVVPG 574
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 324 bits (831), Expect = 2e-88
Identities = 186/575 (32%), Positives = 298/575 (51%), Gaps = 24/575 (4%)
Query: 190 PCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMF 249
P +D F + HA+ ++ + CDV L G AHRLVL++ S YFAA+F
Sbjct: 7 PKAADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALF 66
Query: 250 TNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEAC 309
T ++E+ ++ + + G+E L+ + YTG + + +N++ L+ A +LQL++VV C
Sbjct: 67 TGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLC 126
Query: 310 CKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKL 369
C+FL Q+ P NC+GI F++ C DL + + NY HF+EV +EF+ L ++ K+
Sbjct: 127 CEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKI 186
Query: 370 LASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQ-FLADMENNVLF 428
L S++++I +E + A + W+ DL +RRK + ++L IR PLL PQ L +E F
Sbjct: 187 LRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDF 246
Query: 429 RDDIECQKLIMEAMKYHLLPERR---PMLQSPRTKPRKSTVGTLFAVGGMDSTKGA---- 481
+ Q L+ E + P+ LQ+ + +PRK L+AVGG +G
Sbjct: 247 NLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSD 306
Query: 482 ----TSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPK 537
+ +E++D + WT V++++ R GV VL +Y +GG + ECY+P
Sbjct: 307 SRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPV 366
Query: 538 TKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTP 597
TK W+ + M+ R GLGV V G +YA+GG G NT+ER+DP +W V M+
Sbjct: 367 TKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVS 426
Query: 598 RSTVGVAVLSGKLYAVGGRDGSSC-LKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGL 656
R G + G +Y +GG L+S E +DP + +W+ M RR +GV N
Sbjct: 427 RYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDC 486
Query: 657 LYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGG- 715
+Y++GG N T VE+Y + + W VASM + R + V + LY GG
Sbjct: 487 IYSVGGW-----NETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGR 541
Query: 716 -----YDGQAYLNTVEAYDPQTNEWTQVAPLCLGR 745
+ L++VE Y+P ++ WT++ + R
Sbjct: 542 SSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSR 576
Score = 73.9 bits (180), Expect = 5e-13
Identities = 44/123 (35%), Positives = 60/123 (48%), Gaps = 5/123 (4%)
Query: 627 CFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNL--TSRLSDCVERYDPK 684
C P NK+ Q SK R + LYA+GG+ SR CVER+D
Sbjct: 263 CKSPKENKFCSFLQTSKVRPRKKARKY---LYAVGGYTRLQGGRWSDSRALSCVERFDTF 319
Query: 685 TDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLG 744
+ WT V+S+ +R +GV +LG +YA+GG + E YDP T +WT VA +
Sbjct: 320 SQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHP 379
Query: 745 RAG 747
R G
Sbjct: 380 RCG 382
>gi|223890235 intracisternal A particle-promoted polypeptide isoform
2 [Homo sapiens]
Length = 582
Score = 311 bits (797), Expect = 1e-84
Identities = 178/539 (33%), Positives = 281/539 (52%), Gaps = 18/539 (3%)
Query: 190 PCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMF 249
P +D F + HA+ ++ + CDV L G AHRLVL++ S YFAA+F
Sbjct: 7 PKAADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALF 66
Query: 250 TNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEAC 309
T ++E+ ++ + + G+E L+ + YTG + + +N++ L+ A +LQL++VV C
Sbjct: 67 TGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLC 126
Query: 310 CKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKL 369
C+FL Q+ P NC+GI F++ C DL + + NY HF+EV +EF+ L ++ K+
Sbjct: 127 CEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKI 186
Query: 370 LASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQ-FLADMENNVLF 428
L S++++I +E + A + W+ DL +RRK + ++L IR PLL PQ L +E F
Sbjct: 187 LRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDF 246
Query: 429 RDDIECQKLIMEAMKYHLLPERR---PMLQSPRTKPRKSTVGTLFAVGGMDSTKGA---- 481
+ Q L+ E + P+ LQ+ + +PRK L+AVGG +G
Sbjct: 247 NLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSD 306
Query: 482 ----TSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPK 537
+ +E++D + WT V++++ R GV VL +Y +GG + ECY+P
Sbjct: 307 SRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPV 366
Query: 538 TKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTP 597
TK W+ + M+ R GLGV V G +YA+GG G NT+ER+DP +W V M+
Sbjct: 367 TKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVS 426
Query: 598 RSTVGVAVLSGKLYAVGGRDGSSC-LKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGL 656
R G + G +Y +GG L+S E +DP + +W+ M RR +GV N
Sbjct: 427 RYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDC 486
Query: 657 LYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGG 715
+Y++GG N T VE+Y + + W VASM + R + V + LY GG
Sbjct: 487 IYSVGGW-----NETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG 540
Score = 124 bits (311), Expect = 3e-28
Identities = 67/193 (34%), Positives = 104/193 (53%), Gaps = 15/193 (7%)
Query: 563 MYAVGGHDG-----WS---YLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVG 614
+YAVGG+ WS L+ VER+D ++ W V+++ RS +GV VL G +YA+G
Sbjct: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
Query: 615 GRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRL 674
G S EC+DP T +WT A M+ R G+GV G +YA+GG + + +
Sbjct: 350 GEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGW------VGAEI 403
Query: 675 SDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAY-LNTVEAYDPQTN 733
+ +ER+DP + W V +M++SR G C + +Y +GG + L + E YDP +
Sbjct: 404 GNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSK 463
Query: 734 EWTQVAPLCLGRA 746
W+ + P+ RA
Sbjct: 464 RWSPLPPMGTRRA 476
Score = 106 bits (265), Expect = 7e-23
Identities = 59/156 (37%), Positives = 90/156 (57%), Gaps = 4/156 (2%)
Query: 467 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGG--RDG 524
G ++A+GG + +IE++D N W V NM R FG + +YV+GG +G
Sbjct: 390 GAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEG 449
Query: 525 LKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGG-HDGWSYLNTVERWDP 583
++ L + E Y+P +K WS +PPM T R LGVA L +Y+VGG ++ L+TVE++
Sbjct: 450 IE-LRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSF 508
Query: 584 QARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGS 619
+ +W VA+M PR+ + V ++G LY GGR S
Sbjct: 509 EEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSS 544
Score = 73.9 bits (180), Expect = 5e-13
Identities = 44/123 (35%), Positives = 60/123 (48%), Gaps = 5/123 (4%)
Query: 627 CFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNL--TSRLSDCVERYDPK 684
C P NK+ Q SK R + LYA+GG+ SR CVER+D
Sbjct: 263 CKSPKENKFCSFLQTSKVRPRKKARKY---LYAVGGYTRLQGGRWSDSRALSCVERFDTF 319
Query: 685 TDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLG 744
+ WT V+S+ +R +GV +LG +YA+GG + E YDP T +WT VA +
Sbjct: 320 SQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHP 379
Query: 745 RAG 747
R G
Sbjct: 380 RCG 382
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 300 bits (768), Expect = 3e-81
Identities = 194/604 (32%), Positives = 302/604 (50%), Gaps = 19/604 (3%)
Query: 165 ENESDSSSCRTSNSSQTLSSCHTMEPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVIL 224
E E S LSS F + H+ + + LCDV L
Sbjct: 37 EEEDQHMKLSLGGSEMGLSSHLQSSKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTL 96
Query: 225 VAGDR--RIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGR 282
+ GD P HR++++S SDYF AMFT ++E IK+ GV L +I + YT +
Sbjct: 97 MPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAK 156
Query: 283 LELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAH 342
L L DN++ L A LQ+ V++ C FL+ + NC+ + A+ T++ K +
Sbjct: 157 LSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVN 216
Query: 343 NYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDL 402
++ +++F ++ EF+ LP +A +L+S+ + E + A W+R LE+ R D
Sbjct: 217 SFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLR--LEEPRMDF 274
Query: 403 -SKLLAYIRLPLLAPQFLADMENNVLF-RDDIECQKLIMEAMKYHLLPERRPMLQSPRTK 460
+KL+ IR PL+ PQ L + V F R D C L++EA Y ++P +P++QS RT
Sbjct: 275 AAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTA 334
Query: 461 PRKSTVGTLFAVGGMDSTKGATS--IEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYV 518
R T L +GG+ + S + YD + + W +A M+ R Q G+AV+ + LYV
Sbjct: 335 IRSDTT-HLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYV 393
Query: 519 VGGRD-----GLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWS 573
VGG+ G ++TV ++P+ W + ++ R ++ L+G +YAVGG +
Sbjct: 394 VGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAG 453
Query: 574 YLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTN 633
L TVE ++P+ +W +VA MS P V G +Y GG + K + CFDP T+
Sbjct: 454 ELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTD 513
Query: 634 KWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVAS 693
KW A M+ RG + T LY IGG+ ++ + C E Y P D WT +A+
Sbjct: 514 KWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSC-EYYSPILDQWTPIAA 572
Query: 694 MSISRDAVGVCLLGDKLYAVGGY--DGQAYLNTVEAYDPQTNEWTQV--APLCLGRAGAC 749
M + VGV + +K+Y VGGY + + + V+ YDP +EW +V P LG AC
Sbjct: 573 MLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRAC 632
Query: 750 VVTV 753
+TV
Sbjct: 633 TLTV 636
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 300 bits (767), Expect = 4e-81
Identities = 191/583 (32%), Positives = 298/583 (51%), Gaps = 21/583 (3%)
Query: 188 MEPCTSD--EFFQALNHAEQTFKKMENYLRHKQLCDVILVAGD--RRIPAHRLVLSSVSD 243
++PC + FF + H+ + + LCDV LV GD P HR +++S SD
Sbjct: 16 LQPCKAGTTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASD 75
Query: 244 YFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLS 303
YF AMFT ++E IK+ GV L +I + YT +L L DN++ L A LQ+
Sbjct: 76 YFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQIL 135
Query: 304 QVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPA 363
V++ C FL+ + NC+ + A+ ++ K +N+ +++F ++ EF+ LP
Sbjct: 136 PVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPF 195
Query: 364 SEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKD-LSKLLAYIRLPLLAPQFLADM 422
+A +L+S+ + E + A W+R LE R D +KL+ IR PL+ PQ L +
Sbjct: 196 ERLAFVLSSNSLKHCTELELFKAACRWLR--LEDPRMDYAAKLMKNIRFPLMTPQDLINY 253
Query: 423 ENNVLF-RDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGA 481
V F R D C L++EA Y ++P +P++QS RT R + L +GG+ +
Sbjct: 254 VQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDST-HLVTLGGVLRQQLV 312
Query: 482 TS--IEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRD-----GLKTLNTVECY 534
S + YD R W +A M+ R Q G+AV+ + LYVVGG+ G ++TV +
Sbjct: 313 VSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRF 372
Query: 535 NPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATM 594
+P+ W + ++ R ++ L+G +YAVGG L TVE ++P+ +W++VA M
Sbjct: 373 DPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKM 432
Query: 595 STPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWN 654
S P V G +Y GG + + CFDP T+KW A M+ RG + T
Sbjct: 433 SEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVG 492
Query: 655 GLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVG 714
LY IGG+ ++ + C E Y P D WT +A+M + VGV + +K+Y VG
Sbjct: 493 DKLYVIGGNHFRGTSDYDDVLSC-EYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVG 551
Query: 715 GY--DGQAYLNTVEAYDPQTNEWTQV--APLCLGRAGACVVTV 753
GY + + + V+ YDP+ +EW +V P LG AC +TV
Sbjct: 552 GYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTV 594
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 295 bits (756), Expect = 8e-80
Identities = 187/579 (32%), Positives = 301/579 (51%), Gaps = 32/579 (5%)
Query: 177 NSSQTLSSCHTMEP--CTSDEFFQ---ALNHAEQTFKKMENYLRHKQLCDVILVAGDRRI 231
+S T M+P T EFF +HAE + + + DVI+ +
Sbjct: 18 DSPATKRKVFEMDPKSLTGHEFFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEF 77
Query: 232 PAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIE 291
P HR VLS+ S YF AMF ND RE+R+ +++ G+ ++ +QY YTG++++ +N++
Sbjct: 78 PCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQ 137
Query: 292 CLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFME 351
L T+ L Q+S + +AC KFL +QL P NCLGI+ FAD L N+ ++ F +
Sbjct: 138 YLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFED 197
Query: 352 VIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRL 411
V +++EF+ L E+ + SD++ I EE + A++ WV ++ RR L +LL ++RL
Sbjct: 198 VSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRL 257
Query: 412 PLLAPQ-FLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKST--VGT 468
PLL P F+ +E + L ++ EC +L+ EA +YH+L + SPRT+PR+ST
Sbjct: 258 PLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHILGNE---MMSPRTRPRRSTGYSEV 314
Query: 469 LFAVGGMDSTKG--ATSIEKYDLRTNMWTPVANM-NGRRLQFGVAVLDDKLYVVGGRDGL 525
+ VGG + G E YD T W +A + + ++ V L + + V GGR
Sbjct: 315 IVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINS 374
Query: 526 KTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQA 585
+ V YN + W + ++ R +AVL G +Y VGG+DG + L++VE +D +
Sbjct: 375 R---DVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFS 431
Query: 586 RQWNFVATMSTPRSTVGVAVLSGKLYAV-GGRDGSSCLKSVECFDPHTNKWTLCAQMSKR 644
+W VA + S+ V GKL+ + GG D ++C V+ +DP TN W L A +
Sbjct: 432 NRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIA 491
Query: 645 RGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVC 704
+ + + N L+Y GG L+ + YDP D W V + ++ G+
Sbjct: 492 KRCITAVSLNNLIYVAGG-----------LTKAIYCYDPVEDYWMHVQNTFSRQENCGMS 540
Query: 705 LLGDKLYAVGG--YDGQAYLNTVEAYDPQTNEWTQVAPL 741
+ K+Y +GG +G+A +T+ YDP T+ T VA +
Sbjct: 541 VCNGKIYILGGRRENGEA-TDTILCYDPATSIITGVAAM 578
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 267 bits (683), Expect = 2e-71
Identities = 162/551 (29%), Positives = 276/551 (50%), Gaps = 18/551 (3%)
Query: 210 MENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPN 269
M N + K LCDVIL+ +R+IPAHR+VL++ S +F MFT ++ E++ E++++ EP+
Sbjct: 34 MNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPD 93
Query: 270 SLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFA 329
+ L+++AYT R+ + +N++ LL A Q+ V + C FL +Q+ SNCLGI A
Sbjct: 94 IIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLA 153
Query: 330 DAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLT 389
+ C +L A ++ +HF EV + EF+ L + LL D + + E+ + +A +
Sbjct: 154 ECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVR 213
Query: 390 WVRHDLEQRRKDLSKLLAYIRLPLLAPQFLA-DMENNVLFRDDIECQKLIMEAMKYHLL- 447
W+++D R+ + +LA +R PL++ FL+ ++ L +D+ EC K+++ M+YHLL
Sbjct: 214 WLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLS 273
Query: 448 PERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQF 507
PE R L T+PR+ A+ G + S ++ + WT + +R
Sbjct: 274 PEDREELVD-GTRPRRKKHDYRIALFGGSQPQ---SCRYFNPKDYSWTDIRCPFEKRRDA 329
Query: 508 GVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVG 567
D+ +Y++GG L + ++CYN +W T R L EG +Y G
Sbjct: 330 ACVFWDNVVYILGGSQ-LFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSG 388
Query: 568 GHD-GWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSS----CL 622
G + G S L E +D + W+ +M T R + G+ +G +Y GG G++ L
Sbjct: 389 GSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVL 448
Query: 623 KSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYD 682
S E +DP T WT M + R G+ ++A+GG + D VE YD
Sbjct: 449 NSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGG------LDNVEYYD 502
Query: 683 PKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLC 742
K + W V+ M V +G +Y + G+ G L + Y+ +T++W + +
Sbjct: 503 IKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVR 562
Query: 743 LGRAGACVVTV 753
+C++ V
Sbjct: 563 AFPVTSCLICV 573
Score = 57.8 bits (138), Expect = 4e-08
Identities = 46/188 (24%), Positives = 73/188 (38%), Gaps = 10/188 (5%)
Query: 571 GWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDP 630
G S + ++P+ W + R +Y +GG +K ++C++
Sbjct: 299 GGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFP-IKRMDCYNV 357
Query: 631 HTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTA 690
+ W R + G +Y GG + S L L +C YD +T+ W
Sbjct: 358 VKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALY--LFEC---YDTRTESWHT 412
Query: 691 VASMSISRDAVGVCLLGDKLYAVGGYDGQ----AYLNTVEAYDPQTNEWTQVAPLCLGRA 746
SM R + G+ +Y GG G LN+ E YDP T WT++ P+ R
Sbjct: 413 KPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARK 472
Query: 747 GACVVTVK 754
+V VK
Sbjct: 473 NHGLVFVK 480
>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
Length = 589
Score = 267 bits (682), Expect = 3e-71
Identities = 172/553 (31%), Positives = 270/553 (48%), Gaps = 24/553 (4%)
Query: 197 FQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREA 256
F +H + + +H DV L AGDR P HR VL++ S YF AMF++ +RE+
Sbjct: 23 FHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRES 82
Query: 257 RQEEIKME-GVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMK 315
R + + + + P L L+ +AY+ R+ + E+N E LL +LQ V +A +FL K
Sbjct: 83 RDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEK 142
Query: 316 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDM 375
L PSNCLG+ +DA C L++ + + HF V ++++F L + L++SD++
Sbjct: 143 NLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDEL 202
Query: 376 NIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADMENNVLFRDDIECQ 435
+E + A+L WV+HDLE R+ L +LL +RL LL L + ++ E
Sbjct: 203 ETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMADERT 262
Query: 436 KLIM-EAMKYHL-LPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNM 493
KLIM EA++ + + ++ SP +PRK+ TL +GG T I + D +
Sbjct: 263 KLIMDEALRCKTRILQNDGVVTSPCARPRKAG-HTLLILGG--QTFMCDKIYQVDHKAKE 319
Query: 494 WTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLN-TVECYNPKTKTWSVMPPMSTHRH 552
P A++ R +F + + K+YV GGR ++ V Y+ + WS PM R
Sbjct: 320 IIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARF 379
Query: 553 GLGVAVLEGPMYAVGGHDGWS---------YLNTVERWDPQARQWNFVATMSTPRSTVGV 603
G G A LE +Y VGGH + L VE++DP A +W VA + S V
Sbjct: 380 GHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAV 439
Query: 604 AVLSGKLYAVGGRD-GSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGG 662
KL+ GG + V+C+DP N+WT+ A+ + ++ +GG
Sbjct: 440 VSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGG 499
Query: 663 HDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYL 722
T + R+D +T+ WT + M+ R + G+KLY VGGY G
Sbjct: 500 D-------TEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRC 552
Query: 723 NTVEAYDPQTNEW 735
T++ YDP ++ W
Sbjct: 553 KTLDCYDPTSDTW 565
Score = 65.9 bits (159), Expect = 1e-10
Identities = 48/162 (29%), Positives = 71/162 (43%), Gaps = 9/162 (5%)
Query: 582 DPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCL-KSVECFDPHTNKWTLCAQ 640
D +A++ A + +PR + + K+Y GGR + + K V +D +W+ A
Sbjct: 314 DHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAP 373
Query: 641 MSKRRGGVGVTTWNGLLYAIGGHDA-----PASNLTSRLSDCVERYDPKTDMWTAVASMS 695
M R G G LY +GGH + PAS S VE+YDP + W VA +
Sbjct: 374 MLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQ--VEKYDPGANKWMMVAPLR 431
Query: 696 ISRDAVGVCLLGDKLYAVGGYD-GQAYLNTVEAYDPQTNEWT 736
V KL+ GG + ++ V+ YDP N WT
Sbjct: 432 DGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWT 473
Score = 59.7 bits (143), Expect = 1e-08
Identities = 27/74 (36%), Positives = 43/74 (58%), Gaps = 1/74 (1%)
Query: 469 LFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTL 528
+F +GG D+ A S ++D TN WT + +M +R+ +KLYVVGG G +
Sbjct: 494 IFIMGG-DTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRC 552
Query: 529 NTVECYNPKTKTWS 542
T++CY+P + TW+
Sbjct: 553 KTLDCYDPTSDTWN 566
Score = 51.6 bits (122), Expect = 3e-06
Identities = 33/84 (39%), Positives = 41/84 (48%), Gaps = 9/84 (10%)
Query: 681 YDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQA---------YLNTVEAYDPQ 731
YD + W+ A M I+R G L + LY VGG+ A L VE YDP
Sbjct: 361 YDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPG 420
Query: 732 TNEWTQVAPLCLGRAGACVVTVKL 755
N+W VAPL G + A VV+ KL
Sbjct: 421 ANKWMMVAPLRDGVSNAAVVSAKL 444
Score = 51.6 bits (122), Expect = 3e-06
Identities = 37/140 (26%), Positives = 62/140 (44%), Gaps = 4/140 (2%)
Query: 469 LFAVGGMDSTKGATS-IEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKT 527
LF GG + S ++ YD N WT A AVL +++++GG D T
Sbjct: 446 LFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGG-DTEFT 504
Query: 528 LNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQ 587
+ ++ +T W+ + M+ R +Y VGG+ G T++ +DP +
Sbjct: 505 AASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDT 564
Query: 588 WNFVATMSTPRSTVGVAVLS 607
WN + T+ P S + A +S
Sbjct: 565 WNCITTV--PYSLIPTAFVS 582
Score = 31.2 bits (69), Expect = 3.7
Identities = 19/75 (25%), Positives = 32/75 (42%), Gaps = 1/75 (1%)
Query: 674 LSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNT-VEAYDPQT 732
+ D + + D K A + R +G K+Y GG + ++ V YD
Sbjct: 306 MCDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVH 365
Query: 733 NEWTQVAPLCLGRAG 747
EW++ AP+ + R G
Sbjct: 366 EEWSKAAPMLIARFG 380
>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
Length = 564
Score = 263 bits (673), Expect = 3e-70
Identities = 160/544 (29%), Positives = 273/544 (50%), Gaps = 18/544 (3%)
Query: 217 KQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQ 276
K LCDVIL+ +R+IPAHR+VL++ S +F MFT ++ E++ E++++ EP+ + L++
Sbjct: 19 KTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVE 78
Query: 277 YAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTD 336
+AYT R+ + +N++ LL A Q+ V + C FL +Q+ SNCLGI A+ C +
Sbjct: 79 FAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPE 138
Query: 337 LHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLE 396
L A ++ +HF EV + EF+ L + LL D + + E+ + +A + W+++D
Sbjct: 139 LKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEP 198
Query: 397 QRRKDLSKLLAYIRLPLLAPQFLA-DMENNVLFRDDIECQKLIMEAMKYHLL-PERRPML 454
R+ + +LA +R PL++ FL+ ++ L +D+ EC K+++ M+YHLL PE R L
Sbjct: 199 NRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREEL 258
Query: 455 QSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDD 514
T+PR+ A+ G + S ++ + WT + +R D+
Sbjct: 259 VD-GTRPRRKKHDYRIALFGGSQPQ---SCRYFNPKDYSWTDIRCPFEKRRDAACVFWDN 314
Query: 515 KLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHD-GWS 573
+Y++GG L + ++CYN +W T R L EG +Y GG + G S
Sbjct: 315 VVYILGGSQ-LFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNS 373
Query: 574 YLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSS----CLKSVECFD 629
L E +D + W+ +M T R + G+ +G +Y GG G++ L S E +D
Sbjct: 374 ALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYD 433
Query: 630 PHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWT 689
P T WT M + R G+ ++A+GG + D VE YD K + W
Sbjct: 434 PATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGG------LDNVEYYDIKLNEWK 487
Query: 690 AVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGAC 749
V+ M V +G +Y + G+ G L + Y+ +T++W + + +C
Sbjct: 488 MVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVRAFPVTSC 547
Query: 750 VVTV 753
++ V
Sbjct: 548 LICV 551
Score = 57.8 bits (138), Expect = 4e-08
Identities = 46/188 (24%), Positives = 73/188 (38%), Gaps = 10/188 (5%)
Query: 571 GWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDP 630
G S + ++P+ W + R +Y +GG +K ++C++
Sbjct: 277 GGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFP-IKRMDCYNV 335
Query: 631 HTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTA 690
+ W R + G +Y GG + S L L +C YD +T+ W
Sbjct: 336 VKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALY--LFEC---YDTRTESWHT 390
Query: 691 VASMSISRDAVGVCLLGDKLYAVGGYDGQ----AYLNTVEAYDPQTNEWTQVAPLCLGRA 746
SM R + G+ +Y GG G LN+ E YDP T WT++ P+ R
Sbjct: 391 KPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARK 450
Query: 747 GACVVTVK 754
+V VK
Sbjct: 451 NHGLVFVK 458
>gi|55925608 kelch-like 21 [Homo sapiens]
Length = 597
Score = 260 bits (665), Expect = 3e-69
Identities = 175/553 (31%), Positives = 264/553 (47%), Gaps = 36/553 (6%)
Query: 202 HAEQTFKKMENYLRHKQLCDVIL-VAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEE 260
HA + + ++ DV L AG R PAHR VL++ S YF AMF +RE+R E
Sbjct: 17 HALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAER 76
Query: 261 IKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPS 320
+++ GV P+ L L+ ++YTGR+ + DN E LL A LLQ V EAC FL +QL +
Sbjct: 77 VRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLA 136
Query: 321 NCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNE 380
NCL ++ FA+A C+ L A + + H E + ++ LP + + + L D + +P E
Sbjct: 137 NCLDMQDFAEAFSCSGLASAAQRFILRHVGE-LGAEQLERLPLARLLRYLRDDGLCVPKE 195
Query: 381 ETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQF-LADMENNVLFRDDIECQKLIM 439
E L WVR D +R +LL +RLP + + LA +E L C +L+
Sbjct: 196 EAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLR 255
Query: 440 EAMKYHLLP-ERRPMLQSPRTKPRKST--VGTLFAVGGMD-STKGATSIEKYDLRTNMWT 495
EA + +R PR +PR ST L VGG D +++ Y+ +T W
Sbjct: 256 EARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWR 315
Query: 496 PVA----NMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHR 551
+A ++ G + + L + +YV GG DG + + V YN W+ + PM R
Sbjct: 316 YLAEFPDHLGG---GYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAR 372
Query: 552 HGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLY 611
+VL+G +Y V ++ ER+D W + M+ P G+LY
Sbjct: 373 EYHSSSVLDGLLYVVAA-------DSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLY 425
Query: 612 AVGGRDGSSCLKSVECFDPHTNKWTL--CAQMSKRRGGVGVTTWNGLLYAIGGHDAPASN 669
A+G G + ++C+DP T+ W+L C Q+ T NGL+Y + A
Sbjct: 426 AIGSLAGKETM-VMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVRDDSAE--- 481
Query: 670 LTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYL-NTVEAY 728
V+ Y+P + W + SM+ + +LG KLY GGYD L + VEAY
Sbjct: 482 --------VDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAY 533
Query: 729 DPQTNEWTQVAPL 741
DP+T W+ V L
Sbjct: 534 DPETRAWSVVGRL 546
Score = 56.2 bits (134), Expect = 1e-07
Identities = 42/134 (31%), Positives = 64/134 (47%), Gaps = 9/134 (6%)
Query: 467 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFG--VAVLDDKLYVVGGRDG 524
G L+A+G + + K ++ YD T++W+ V F A L+ +Y V RD
Sbjct: 422 GRLYAIGSL-AGKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFV--RDD 478
Query: 525 LKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLN-TVERWDP 583
V+ YNP W +P M+ G +AVL G +Y GG+D L+ VE +DP
Sbjct: 479 SAE---VDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDP 535
Query: 584 QARQWNFVATMSTP 597
+ R W+ V + P
Sbjct: 536 ETRAWSVVGRLPEP 549
Score = 48.9 bits (115), Expect = 2e-05
Identities = 29/94 (30%), Positives = 44/94 (46%), Gaps = 12/94 (12%)
Query: 656 LLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVG----VCLLGDKLY 711
+L +GG D L + V+ Y+P+T W +A D +G + LG+ +Y
Sbjct: 287 ILVLVGGCDQDCDELVT-----VDCYNPQTGQWRYLAEFP---DHLGGGYSIVALGNDIY 338
Query: 712 AVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGR 745
GG DG + V Y+ NEW +VAP+ R
Sbjct: 339 VTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAR 372
>gi|8922854 kelch-like 26 [Homo sapiens]
Length = 615
Score = 260 bits (664), Expect = 4e-69
Identities = 178/577 (30%), Positives = 274/577 (47%), Gaps = 30/577 (5%)
Query: 197 FQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREA 256
F A +H+ + + QL DV+L PAH++VL++ SDYF AMFT +REA
Sbjct: 40 FSAPSHSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREA 99
Query: 257 RQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQ 316
Q+ I+++GV L +I +AY+ + L D ++ +L A LQ+ VVE C +FL
Sbjct: 100 SQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAA 159
Query: 317 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMN 376
+ CL I A L + +T HF+++ ++F+ LP + L S+ +
Sbjct: 160 MSVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQ 219
Query: 377 IPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADMENNV-LFRDDIECQ 435
E + A + W++HD RR S +L +IR PL+ L D + + +D+ C+
Sbjct: 220 SCAEIDLFRAAVRWLQHD-PARRPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLCR 278
Query: 436 KLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEK--YDL---R 490
+ ++EA Y +LP R+ +QSPRT R S V +L GG T S+ Y L
Sbjct: 279 QYLLEAFNYQVLPFRQHEMQSPRTAVR-SDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPG 337
Query: 491 TNMWTPVANMNGRRLQFGVAVLDDKLYVVGG-----RDGLKTLNTVECYNPKTKTWSVMP 545
+ + M VAVLD+ +YV GG R G ++ Y+P W +
Sbjct: 338 ARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQ 397
Query: 546 PMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAV 605
M R + VL G +YA GG + L +VER+ P+ +W + ++ A
Sbjct: 398 AMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAGAA 457
Query: 606 LSGKLYAVGGRDGS-SCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHD 664
G+LY GG S K++ C+DP ++W A MS+ R + G +YA+GG
Sbjct: 458 SGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGRM 517
Query: 665 APASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQA--YL 722
L+ VE Y P+TD WT+V+ M + G CLL K+Y VGGY+ +
Sbjct: 518 DHVDRCFDVLA--VEYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNWRLNNVT 575
Query: 723 NTVEAYDPQTNEWTQ------------VAPLCLGRAG 747
V+ Y+ T+EW + AP+ L RAG
Sbjct: 576 GIVQVYNTDTDEWERDLHFPESFAGIACAPVLLPRAG 612
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 251 bits (642), Expect = 1e-66
Identities = 162/566 (28%), Positives = 270/566 (47%), Gaps = 43/566 (7%)
Query: 210 MENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPN 269
+E L DVIL + HR+VL++ S+YF AMF ND++E ++ I ++GV+
Sbjct: 62 LETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAE 121
Query: 270 SLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFA 329
++ +L+ Y YT + + + N++ +L A L Q ++V+AC FL + L+P NC+GI A
Sbjct: 122 TMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLA 181
Query: 330 DAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLT 389
D L K +Y +++F++++ ++EF+ LP + +L SDD+ + E + +++
Sbjct: 182 DTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMS 241
Query: 390 WVRHDLEQRRKDLSKLLAYIRLPLLAP-QFLADMENNVLFRDDIECQKLIMEAMKYHLLP 448
WVRH +R L +L +RLPLL P F+ +E + L R E L+ EA YHL
Sbjct: 242 WVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLSG 301
Query: 449 ERRPMLQSPRTKPRKSTV-GTLFAVGGMDSTKGATSIEKYDLRTNMWTP----------- 496
+ S RTKPR +F + G G T E++ P
Sbjct: 302 NE---IISERTKPRMHEFQSEVFMIIG-----GCTKDERFVAEVTCLDPLRRSRLEVAKL 353
Query: 497 ------VANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTH 550
+ + N + ++F L +++Y+ GG++ T + V YN W + ++
Sbjct: 354 PLTEHELESENKKWVEFACVTLKNEVYISGGKE---TQHDVWKYNSSINKWIQIEYLNIG 410
Query: 551 RHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKL 610
R + VL G +Y +GG DG +N VE +DP W+ A + S+ KL
Sbjct: 411 RWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKL 470
Query: 611 YAV-GGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASN 669
Y + GG +G +C+DP TNKW+L A M + ++ +Y +GG
Sbjct: 471 YVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGG------- 523
Query: 670 LTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQ-AYLNTVEAY 728
+ Y P D W V +S R + G+ ++LY GG D + + TV +
Sbjct: 524 ----AMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCW 579
Query: 729 DPQTNEWTQVAPLCLGRAGACVVTVK 754
DP+ + T+ L G + VT++
Sbjct: 580 DPEAQKLTEECVLPRGVSHHGSVTIR 605
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.133 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,979,674
Number of Sequences: 37866
Number of extensions: 1274678
Number of successful extensions: 5074
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 173
Number of HSP's successfully gapped in prelim test: 32
Number of HSP's that attempted gapping in prelim test: 3425
Number of HSP's gapped (non-prelim): 461
length of query: 755
length of database: 18,247,518
effective HSP length: 110
effective length of query: 645
effective length of database: 14,082,258
effective search space: 9083056410
effective search space used: 9083056410
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.