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Search of human proteins with 63998898
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo
sapiens]
(510 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo sa... 1032 0.0
gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo sa... 623 e-178
gi|42794767 mitogen-activated protein kinase kinase kinase 3 iso... 238 1e-62
gi|42794765 mitogen-activated protein kinase kinase kinase 3 iso... 238 1e-62
gi|85838511 mitogen-activated protein kinase kinase kinase 2 [Ho... 234 1e-61
gi|121583542 mitogen-activated protein kinase kinase kinase 15 [... 200 3e-51
gi|5174547 mitogen-activated protein kinase kinase kinase 5 [Hom... 193 4e-49
gi|45827809 mitogen-activated protein kinase kinase kinase 6 [Ho... 186 4e-47
gi|153945765 mitogen-activated protein kinase kinase kinase 1 [H... 184 1e-46
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 175 1e-43
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 175 1e-43
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 174 2e-43
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 171 1e-42
gi|55956904 mitogen-activated protein kinase kinase kinase 4 iso... 171 1e-42
gi|55956902 mitogen-activated protein kinase kinase kinase 4 iso... 171 1e-42
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 168 1e-41
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 166 4e-41
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 165 8e-41
gi|14589909 mitogen-activated protein kinase kinase kinase kinas... 165 8e-41
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 164 2e-40
gi|4759208 TAO kinase 2 isoform 1 [Homo sapiens] 160 3e-39
gi|45505130 TAO kinase 2 isoform 2 [Homo sapiens] 160 3e-39
gi|32483399 p21-activated kinase 2 [Homo sapiens] 159 6e-39
gi|45439370 TAO kinase 1 [Homo sapiens] 159 6e-39
gi|148746218 TAO kinase 3 [Homo sapiens] 159 6e-39
gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens] 158 1e-38
gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens] 158 1e-38
gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens] 158 1e-38
gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens] 158 1e-38
gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens] 158 1e-38
>gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo
sapiens]
Length = 510
Score = 1032 bits (2669), Expect = 0.0
Identities = 510/510 (100%), Positives = 510/510 (100%)
Query: 1 MSSMPKPERHAESLLDICHDTNSSPTDLMTVTKNQNIILQSISRSEEFDQDGDCSHSTLV 60
MSSMPKPERHAESLLDICHDTNSSPTDLMTVTKNQNIILQSISRSEEFDQDGDCSHSTLV
Sbjct: 1 MSSMPKPERHAESLLDICHDTNSSPTDLMTVTKNQNIILQSISRSEEFDQDGDCSHSTLV 60
Query: 61 NEEEDPSGGRQDWQPRTEGVEITVTFPRDVSPPQEMSQEDLKEKNLINSSLQEWAQAHAV 120
NEEEDPSGGRQDWQPRTEGVEITVTFPRDVSPPQEMSQEDLKEKNLINSSLQEWAQAHAV
Sbjct: 61 NEEEDPSGGRQDWQPRTEGVEITVTFPRDVSPPQEMSQEDLKEKNLINSSLQEWAQAHAV 120
Query: 121 SHPNEIETVELRKKKLTMRPLVLQKEESSRELCNVNLGFLLPRSCLELNISKSVTREDAP 180
SHPNEIETVELRKKKLTMRPLVLQKEESSRELCNVNLGFLLPRSCLELNISKSVTREDAP
Sbjct: 121 SHPNEIETVELRKKKLTMRPLVLQKEESSRELCNVNLGFLLPRSCLELNISKSVTREDAP 180
Query: 181 HFLKEQQRKSEEFSTSHMKYSGRSIKRHSSGLRIYDREEKFLISNEKKIFSENSLKSEEP 240
HFLKEQQRKSEEFSTSHMKYSGRSIKRHSSGLRIYDREEKFLISNEKKIFSENSLKSEEP
Sbjct: 181 HFLKEQQRKSEEFSTSHMKYSGRSIKRHSSGLRIYDREEKFLISNEKKIFSENSLKSEEP 240
Query: 241 ILWTKGEILGKGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKAL 300
ILWTKGEILGKGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKAL
Sbjct: 241 ILWTKGEILGKGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKAL 300
Query: 301 KHVNIVAYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLH 360
KHVNIVAYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLH
Sbjct: 301 KHVNIVAYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLH 360
Query: 361 ENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEV 420
ENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEV
Sbjct: 361 ENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEV 420
Query: 421 INESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSENAA 480
INESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSENAA
Sbjct: 421 INESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSENAA 480
Query: 481 DFVRMCLTRDQHERPSALQLLKHSFLERSH 510
DFVRMCLTRDQHERPSALQLLKHSFLERSH
Sbjct: 481 DFVRMCLTRDQHERPSALQLLKHSFLERSH 510
>gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo
sapiens]
Length = 1328
Score = 623 bits (1607), Expect = e-178
Identities = 330/424 (77%), Positives = 348/424 (82%), Gaps = 21/424 (4%)
Query: 102 KEKNLINSSLQEWAQAHAVSHP---NEIETVELRKKKLTMRPLVLQK-------EESSRE 151
K+++ + + Q W H + H N+ T ++ K L+ + Q+ EE + E
Sbjct: 911 KQESASSQTYQYWV--HYLDHDSLANKSITYQMFGKTLSGTNSISQEIMDSVNNEELTDE 968
Query: 152 LCNVNLGFLLPRSCLELNISKSVTREDAPHFLKEQQRKSEEFSTSHMKYSGRS-----IK 206
L LL + N + + E P L R + S K GR I+
Sbjct: 969 LLGCLAAELLALDEKDNNSCQKMANETDPENLNLVLR----WRGSTPKEMGRETTKVKIQ 1024
Query: 207 RHSSGLRIYDREEKFLISNEKKIFSENSLKSEEPILWTKGEILGKGAYGTVYCGLTSQGQ 266
RHSSGLRIYDREEKFLISNEKKIFSENSLKSEEPILWTKGEILGKGAYGTVYCGLTSQGQ
Sbjct: 1025 RHSSGLRIYDREEKFLISNEKKIFSENSLKSEEPILWTKGEILGKGAYGTVYCGLTSQGQ 1084
Query: 267 LIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVP 326
LIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVP
Sbjct: 1085 LIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVP 1144
Query: 327 GGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLID 386
GGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLID
Sbjct: 1145 GGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLID 1204
Query: 387 FGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGK 446
FGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGK
Sbjct: 1205 FGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGK 1264
Query: 447 PPLASMDRMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFL 506
PPLASMDRMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFL
Sbjct: 1265 PPLASMDRMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFL 1324
Query: 507 ERSH 510
ERSH
Sbjct: 1325 ERSH 1328
Score = 416 bits (1068), Expect = e-116
Identities = 206/206 (100%), Positives = 206/206 (100%)
Query: 1 MSSMPKPERHAESLLDICHDTNSSPTDLMTVTKNQNIILQSISRSEEFDQDGDCSHSTLV 60
MSSMPKPERHAESLLDICHDTNSSPTDLMTVTKNQNIILQSISRSEEFDQDGDCSHSTLV
Sbjct: 1 MSSMPKPERHAESLLDICHDTNSSPTDLMTVTKNQNIILQSISRSEEFDQDGDCSHSTLV 60
Query: 61 NEEEDPSGGRQDWQPRTEGVEITVTFPRDVSPPQEMSQEDLKEKNLINSSLQEWAQAHAV 120
NEEEDPSGGRQDWQPRTEGVEITVTFPRDVSPPQEMSQEDLKEKNLINSSLQEWAQAHAV
Sbjct: 61 NEEEDPSGGRQDWQPRTEGVEITVTFPRDVSPPQEMSQEDLKEKNLINSSLQEWAQAHAV 120
Query: 121 SHPNEIETVELRKKKLTMRPLVLQKEESSRELCNVNLGFLLPRSCLELNISKSVTREDAP 180
SHPNEIETVELRKKKLTMRPLVLQKEESSRELCNVNLGFLLPRSCLELNISKSVTREDAP
Sbjct: 121 SHPNEIETVELRKKKLTMRPLVLQKEESSRELCNVNLGFLLPRSCLELNISKSVTREDAP 180
Query: 181 HFLKEQQRKSEEFSTSHMKYSGRSIK 206
HFLKEQQRKSEEFSTSHMKYSGRSIK
Sbjct: 181 HFLKEQQRKSEEFSTSHMKYSGRSIK 206
>gi|42794767 mitogen-activated protein kinase kinase kinase 3
isoform 1 [Homo sapiens]
Length = 657
Score = 238 bits (606), Expect = 1e-62
Identities = 134/291 (46%), Positives = 184/291 (63%), Gaps = 21/291 (7%)
Query: 231 SENSLKSEE----------PILWTKGEILGKGAYGTVY-CGLTSQGQLIAVKQVALDTSN 279
SEN+L +E PI W +G++LG+GA+G VY C G+ +A KQV D +
Sbjct: 371 SENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDS 430
Query: 280 KLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQ---ENTVSIFMEFVPGGSISSIINR 336
KE L+ E+ LLK L+H IV Y G CL+ E T++IFME++PGGS+ +
Sbjct: 431 P-ETSKEVSALECEIQLLKNLQHERIVQYYG-CLRDRAEKTLTIFMEYMPGGSVKDQLKA 488
Query: 337 FGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWA 396
+G L E V KYT+QIL+G++YLH N +VHRDIKG N++ G +KL DFG ++RL
Sbjct: 489 YGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTI 548
Query: 397 GLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMA 456
++GT ++S+ GTPYWM+PEVI+ GYGRK+D+WS+GCTV EM T KPP A + MA
Sbjct: 549 CMSGTG---MRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMA 605
Query: 457 AMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFLE 507
A+F I A + P LP H SE+ DF+R + +RPSA +LL H F +
Sbjct: 606 AIFKI-ATQPTNPQLPSHISEHGRDFLRRIFV-EARQRPSAEELLTHHFAQ 654
>gi|42794765 mitogen-activated protein kinase kinase kinase 3
isoform 2 [Homo sapiens]
Length = 626
Score = 238 bits (606), Expect = 1e-62
Identities = 134/291 (46%), Positives = 184/291 (63%), Gaps = 21/291 (7%)
Query: 231 SENSLKSEE----------PILWTKGEILGKGAYGTVY-CGLTSQGQLIAVKQVALDTSN 279
SEN+L +E PI W +G++LG+GA+G VY C G+ +A KQV D +
Sbjct: 340 SENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDS 399
Query: 280 KLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQ---ENTVSIFMEFVPGGSISSIINR 336
KE L+ E+ LLK L+H IV Y G CL+ E T++IFME++PGGS+ +
Sbjct: 400 P-ETSKEVSALECEIQLLKNLQHERIVQYYG-CLRDRAEKTLTIFMEYMPGGSVKDQLKA 457
Query: 337 FGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWA 396
+G L E V KYT+QIL+G++YLH N +VHRDIKG N++ G +KL DFG ++RL
Sbjct: 458 YGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTI 517
Query: 397 GLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMA 456
++GT ++S+ GTPYWM+PEVI+ GYGRK+D+WS+GCTV EM T KPP A + MA
Sbjct: 518 CMSGTG---MRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMA 574
Query: 457 AMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFLE 507
A+F I A + P LP H SE+ DF+R + +RPSA +LL H F +
Sbjct: 575 AIFKI-ATQPTNPQLPSHISEHGRDFLRRIFV-EARQRPSAEELLTHHFAQ 623
>gi|85838511 mitogen-activated protein kinase kinase kinase 2 [Homo
sapiens]
Length = 619
Score = 234 bits (597), Expect = 1e-61
Identities = 136/280 (48%), Positives = 175/280 (62%), Gaps = 11/280 (3%)
Query: 231 SENSLKSEEPILWTKGEILGKGAYGTVY-CGLTSQGQLIAVKQVALDTSNKLAAEKEYRK 289
S S P W G++LG+GA+G VY C G+ +AVKQV D + KE
Sbjct: 344 SPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSP-ETSKEVNA 402
Query: 290 LQEEVDLLKALKHVNIVAYLGTCL---QENTVSIFMEFVPGGSISSIINRFGPLPEMVFC 346
L+ E+ LLK L H IV Y G CL QE T+SIFME++PGGSI + +G L E V
Sbjct: 403 LECEIQLLKNLLHERIVQYYG-CLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTR 461
Query: 347 KYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDML 406
KYT+QIL+GV YLH N +VHRDIKG N++ TG +KL DFG ++RL L+GT +
Sbjct: 462 KYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTG---M 518
Query: 407 KSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRG 466
KS+ GTPYWM+PEVI+ GYGRK+DIWS+ CTV EM T KPP A + MAA+F I A +
Sbjct: 519 KSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKI-ATQP 577
Query: 467 LMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFL 506
P LP H S+ DF++ + RPSA +LL+H F+
Sbjct: 578 TNPKLPPHVSDYTRDFLKRIFV-EAKLRPSADELLRHMFV 616
>gi|121583542 mitogen-activated protein kinase kinase kinase 15
[Homo sapiens]
Length = 788
Score = 200 bits (508), Expect = 3e-51
Identities = 114/267 (42%), Positives = 168/267 (62%), Gaps = 19/267 (7%)
Query: 248 ILGKGAYGTVYCGLTSQGQL-IAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIV 306
+LGKG YG VY G Q+ IA+K++ S + + L EE+ L K LKH NIV
Sbjct: 132 VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDS------RYSQPLHEEIALHKYLKHRNIV 185
Query: 307 AYLGTCLQENTVSIFMEFVPGGSISSII-NRFGPLPEMVFCKYTKQILQGVAYLHENCVV 365
YLG+ + + IFME VPGGS+S+++ +++GP+ E YTKQIL+G+ YLHEN +V
Sbjct: 186 QYLGSVSENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIV 245
Query: 366 HRDIKGNNVMLMP-TGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINES 424
HRDIKG+NV++ +G++K+ DFG ++RLA G+N ++ GT +MAPE+I++
Sbjct: 246 HRDIKGDNVLVNTYSGVVKISDFGTSKRLA--GVN----PCTETFTGTLQYMAPEIIDQG 299
Query: 425 --GYGRKSDIWSIGCTVFEMATGKPPLASM-DRMAAMFYIGAHRGLMPPLPDHFSENAAD 481
GYG +DIWS+GCT+ EMAT KPP + + AAMF +G + + P +P+ S A
Sbjct: 300 PRGYGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFK-IHPEIPEALSAEARA 358
Query: 482 FVRMCLTRDQHERPSALQLLKHSFLER 508
F+ C D H+R + +LL+ FL +
Sbjct: 359 FILSCFEPDPHKRATTAELLREGFLRQ 385
>gi|5174547 mitogen-activated protein kinase kinase kinase 5 [Homo
sapiens]
Length = 1374
Score = 193 bits (490), Expect = 4e-49
Identities = 116/270 (42%), Positives = 168/270 (62%), Gaps = 21/270 (7%)
Query: 248 ILGKGAYGTVYCGLTSQGQL-IAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIV 306
+LGKG YG VY G Q+ IA+K++ S + + L EE+ L K LKH NIV
Sbjct: 685 VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDS------RYSQPLHEEIALHKHLKHKNIV 738
Query: 307 AYLGTCLQENTVSIFMEFVPGGSISSII-NRFGPLP--EMVFCKYTKQILQGVAYLHENC 363
YLG+ + + IFME VPGGS+S+++ +++GPL E YTKQIL+G+ YLH+N
Sbjct: 739 QYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQ 798
Query: 364 VVHRDIKGNNVMLMP-TGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVIN 422
+VHRDIKG+NV++ +G++K+ DFG ++RLA G+N ++ GT +MAPE+I+
Sbjct: 799 IVHRDIKGDNVLINTYSGVLKISDFGTSKRLA--GIN----PCTETFTGTLQYMAPEIID 852
Query: 423 ES--GYGRKSDIWSIGCTVFEMATGKPPLASM-DRMAAMFYIGAHRGLMPPLPDHFSENA 479
+ GYG+ +DIWS+GCT+ EMATGKPP + + AAMF +G + + P +P+ S A
Sbjct: 853 KGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFK-VHPEIPESMSAEA 911
Query: 480 ADFVRMCLTRDQHERPSALQLLKHSFLERS 509
F+ C D +R A LL FL+ S
Sbjct: 912 KAFILKCFEPDPDKRACANDLLVDEFLKVS 941
>gi|45827809 mitogen-activated protein kinase kinase kinase 6 [Homo
sapiens]
Length = 1288
Score = 186 bits (472), Expect = 4e-47
Identities = 113/268 (42%), Positives = 162/268 (60%), Gaps = 21/268 (7%)
Query: 248 ILGKGAYGTVYCGLTSQGQL-IAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIV 306
+LGKG YG VY G ++ IA+K++ S + + L EE+ L + L+H NIV
Sbjct: 653 VLGKGTYGVVYAGRDRHTRVRIAIKEIPERDS------RFSQPLHEEIALHRRLRHKNIV 706
Query: 307 AYLGTCLQENTVSIFMEFVPGGSISSIINR-FGPLP--EMVFCKYTKQILQGVAYLHENC 363
YLG+ Q + IFME VPGGS+SS++ +GPL E YT+QILQG+ YLH+N
Sbjct: 707 RYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNH 766
Query: 364 VVHRDIKGNNVMLMP-TGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVIN 422
+VHRDIKG+NV++ +G++K+ DFG ++RLA + ++ GT +MAPE+I+
Sbjct: 767 IVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGI------TPCTETFTGTLQYMAPEIID 820
Query: 423 ES--GYGRKSDIWSIGCTVFEMATGKPPLASM-DRMAAMFYIGAHRGLMPPLPDHFSENA 479
+ GYG+ +DIWS+GCTV EMATG+PP + AAMF +G ++ + PP+P S A
Sbjct: 821 QGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYK-VHPPMPSSLSAEA 879
Query: 480 ADFVRMCLTRDQHERPSALQLLKHSFLE 507
F+ D R SA LL FL+
Sbjct: 880 QAFLLRTFEPDPRLRASAQTLLGDPFLQ 907
>gi|153945765 mitogen-activated protein kinase kinase kinase 1 [Homo
sapiens]
Length = 1512
Score = 184 bits (468), Expect = 1e-46
Identities = 119/422 (28%), Positives = 211/422 (50%), Gaps = 39/422 (9%)
Query: 91 SPPQEMSQEDLKEKNLINSSLQEWAQAHAVSHPNEIETVELRKKKLTMRPLVLQKEESSR 150
+P +E + D+ + +NSS+++ +A S P+ TV + + + P + +++ +
Sbjct: 1114 TPVEEKCRLDVNTE--LNSSIEDLLEA---SMPSSDTTVTFKSEVAVLSPEKAENDDTYK 1168
Query: 151 ELCNVNLGFLLPRSCLELNISKSVTREDAPHFLKEQQRKSEEFSTSHMKYSGRSIKRHSS 210
+ N N + C E K + + E + + + +
Sbjct: 1169 DDVNHN------QKCKE----------------KMEAEEEEALAIAMAMSASQDALPIVP 1206
Query: 211 GLRIYDREEKFLISNEKKIFSENSLKSEEPIL----WTKGEILGKGAYGTVYCGL-TSQG 265
L++ + E+ +I + K+++P W KG+ +G GA+ + Y G
Sbjct: 1207 QLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQAQDVGTG 1266
Query: 266 QLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFMEFV 325
L+AVKQV + E+ L+EE+ ++ L H NI+ LG +++ ++F+E++
Sbjct: 1267 TLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWM 1326
Query: 326 PGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTG-IIKL 384
GGS++ +++++G E V YT+Q+L+G++YLHEN ++HRD+KG N+++ TG +++
Sbjct: 1327 AGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRI 1386
Query: 385 IDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMAT 444
DFG A RLA G + + GT +MAPEV+ YGR D+WS+GC + EMA
Sbjct: 1387 ADFGAAARLASKGTGA--GEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMAC 1444
Query: 445 GKPPLAS---MDRMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLL 501
KPP + + +A +F I A P +P H S D CL +RP + +LL
Sbjct: 1445 AKPPWNAEKHSNHLALIFKI-ASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELL 1503
Query: 502 KH 503
KH
Sbjct: 1504 KH 1505
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 175 bits (443), Expect = 1e-43
Identities = 100/277 (36%), Positives = 159/277 (57%), Gaps = 15/277 (5%)
Query: 234 SLKSEEPILWTKGEILGKGAYGTVYCGLTSQGQ-LIAVKQVALDTSNKLAAEKEYRKLQE 292
+LK++ L+TK E +GKG++G V+ G+ ++ Q ++A+K + L+ AE E +Q+
Sbjct: 15 NLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEE-----AEDEIEDIQQ 69
Query: 293 EVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQI 352
E+ +L + Y G+ L++ + I ME++ GGS ++ GPL E ++I
Sbjct: 70 EITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEP-GPLDETQIATILREI 128
Query: 353 LQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGT 412
L+G+ YLH +HRDIK NV+L G +KL DFG A +L + + GT
Sbjct: 129 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRN------TFVGT 182
Query: 413 PYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLP 472
P+WMAPEVI +S Y K+DIWS+G T E+A G+PP + + M +F I + P L
Sbjct: 183 PFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNN--PPTLE 240
Query: 473 DHFSENAADFVRMCLTRDQHERPSALQLLKHSFLERS 509
++S+ +FV CL ++ RP+A +LLKH F+ R+
Sbjct: 241 GNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRN 277
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 175 bits (443), Expect = 1e-43
Identities = 100/277 (36%), Positives = 159/277 (57%), Gaps = 15/277 (5%)
Query: 234 SLKSEEPILWTKGEILGKGAYGTVYCGLTSQGQ-LIAVKQVALDTSNKLAAEKEYRKLQE 292
+LK++ L+TK E +GKG++G V+ G+ ++ Q ++A+K + L+ AE E +Q+
Sbjct: 27 NLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEE-----AEDEIEDIQQ 81
Query: 293 EVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQI 352
E+ +L + Y G+ L++ + I ME++ GGS ++ GPL E ++I
Sbjct: 82 EITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEP-GPLDETQIATILREI 140
Query: 353 LQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGT 412
L+G+ YLH +HRDIK NV+L G +KL DFG A +L + + GT
Sbjct: 141 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRN------TFVGT 194
Query: 413 PYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLP 472
P+WMAPEVI +S Y K+DIWS+G T E+A G+PP + + M +F I + P L
Sbjct: 195 PFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNN--PPTLE 252
Query: 473 DHFSENAADFVRMCLTRDQHERPSALQLLKHSFLERS 509
++S+ +FV CL ++ RP+A +LLKH F+ R+
Sbjct: 253 GNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRN 289
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 174 bits (440), Expect = 2e-43
Identities = 101/279 (36%), Positives = 159/279 (56%), Gaps = 16/279 (5%)
Query: 232 ENSLKSEEPILWTKGEILGKGAYGTVYCGLTSQGQ-LIAVKQVALDTSNKLAAEKEYRKL 290
+N++ E L+TK E +GKG++G V+ G+ ++ Q ++A+K + L+ AE E +
Sbjct: 14 QNNIADPEE-LFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEE-----AEDEIEDI 67
Query: 291 QEEVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTK 350
Q+E+ +L + Y G+ L+ + + I ME++ GGS ++ R GP E K
Sbjct: 68 QQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLL-RAGPFDEFQIATMLK 126
Query: 351 QILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMH 410
+IL+G+ YLH +HRDIK NV+L G +KL DFG A +L + +
Sbjct: 127 EILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRN------TFV 180
Query: 411 GTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPP 470
GTP+WMAPEVI +S Y K+DIWS+G T E+A G+PP + M M +F I + P
Sbjct: 181 GTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNN--PPT 238
Query: 471 LPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFLERS 509
L F+++ +F+ CL +D RP+A +LLKH F+ ++
Sbjct: 239 LVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKN 277
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 171 bits (433), Expect = 1e-42
Identities = 100/280 (35%), Positives = 153/280 (54%), Gaps = 15/280 (5%)
Query: 230 FSENSLKSEEPILWTKGEILGKGAYGTVYCGLTSQG-QLIAVKQVALDTSNKLAAEKEYR 288
F+ + + L+TK + +GKG++G VY G+ + +++A+K + L+ AE E
Sbjct: 7 FANQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEE-----AEDEIE 61
Query: 289 KLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKY 348
+Q+E+ +L I Y G+ L+ + I ME++ GGS ++ GPL E
Sbjct: 62 DIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKP-GPLEETYIATI 120
Query: 349 TKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKS 408
++IL+G+ YLH +HRDIK NV+L G +KL DFG A +L + +
Sbjct: 121 LREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRN------T 174
Query: 409 MHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLM 468
GTP+WMAPEVI +S Y K+DIWS+G T E+A G+PP + + M +F I +
Sbjct: 175 FVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLI--PKNSP 232
Query: 469 PPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFLER 508
P L S+ +FV CL +D RP+A +LLKH F+ R
Sbjct: 233 PTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITR 272
>gi|55956904 mitogen-activated protein kinase kinase kinase 4 isoform
a [Homo sapiens]
Length = 1608
Score = 171 bits (433), Expect = 1e-42
Identities = 103/270 (38%), Positives = 151/270 (55%), Gaps = 15/270 (5%)
Query: 243 WTKGEILGKGAYGTVY-CGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALK 301
W +G +G+G YG VY C G+L+A+K++ ++ K ++ +E+ + + +K
Sbjct: 1343 WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND----HKTIKETADELKIFEGIK 1398
Query: 302 HVNIVAYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHE 361
H N+V Y G L + IFME+ G++ + +R G L E V Y+KQI + LHE
Sbjct: 1399 HPNLVRYFGVELHREEMYIFMEYCDEGTLEEV-SRLG-LQEHVIRLYSKQITIAINVLHE 1456
Query: 362 NCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVI 421
+ +VHRDIKG N+ L +G+IKL DFGC+ +L T + S GT +MAPEVI
Sbjct: 1457 HGIVHRDIKGANIFLTSSGLIKLGDFGCSVKL--KNNAQTMPGEVNSTLGTAAYMAPEVI 1514
Query: 422 NES---GYGRKSDIWSIGCTVFEMATGKPPLASMD-RMAAMFYIGAHRGLMPPLPDHFSE 477
+ G+GR +DIWS+GC V EM TGK P + M+ +G G PP+P+ S
Sbjct: 1515 TRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVG--MGHKPPIPERLSP 1572
Query: 478 NAADFVRMCLTRDQHERPSALQLLKHSFLE 507
DF+ CL D R +A QLL HSF++
Sbjct: 1573 EGKDFLSHCLESDPKMRWTASQLLDHSFVK 1602
>gi|55956902 mitogen-activated protein kinase kinase kinase 4 isoform
b [Homo sapiens]
Length = 1558
Score = 171 bits (433), Expect = 1e-42
Identities = 103/270 (38%), Positives = 151/270 (55%), Gaps = 15/270 (5%)
Query: 243 WTKGEILGKGAYGTVY-CGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALK 301
W +G +G+G YG VY C G+L+A+K++ ++ K ++ +E+ + + +K
Sbjct: 1293 WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND----HKTIKETADELKIFEGIK 1348
Query: 302 HVNIVAYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHE 361
H N+V Y G L + IFME+ G++ + +R G L E V Y+KQI + LHE
Sbjct: 1349 HPNLVRYFGVELHREEMYIFMEYCDEGTLEEV-SRLG-LQEHVIRLYSKQITIAINVLHE 1406
Query: 362 NCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVI 421
+ +VHRDIKG N+ L +G+IKL DFGC+ +L T + S GT +MAPEVI
Sbjct: 1407 HGIVHRDIKGANIFLTSSGLIKLGDFGCSVKL--KNNAQTMPGEVNSTLGTAAYMAPEVI 1464
Query: 422 NES---GYGRKSDIWSIGCTVFEMATGKPPLASMD-RMAAMFYIGAHRGLMPPLPDHFSE 477
+ G+GR +DIWS+GC V EM TGK P + M+ +G G PP+P+ S
Sbjct: 1465 TRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVG--MGHKPPIPERLSP 1522
Query: 478 NAADFVRMCLTRDQHERPSALQLLKHSFLE 507
DF+ CL D R +A QLL HSF++
Sbjct: 1523 EGKDFLSHCLESDPKMRWTASQLLDHSFVK 1552
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 168 bits (425), Expect = 1e-41
Identities = 99/264 (37%), Positives = 151/264 (57%), Gaps = 18/264 (6%)
Query: 249 LGKGAYGTVYCGLT-SQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVA 307
+G G YG VY + G+L A+K + KL +++ +Q+E+ ++K KH NIVA
Sbjct: 22 IGSGTYGDVYKARNVNTGELAAIKVI------KLEPGEDFAVVQQEIIMMKDCKHPNIVA 75
Query: 308 YLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENCVVHR 367
Y G+ L+ + + I MEF GGS+ I + GPL E+ +++ LQG+ YLH +HR
Sbjct: 76 YFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKMHR 135
Query: 368 DIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVI---NES 424
DIKG N++L G +KL DFG + A + T + KS GTPYWMAPEV +
Sbjct: 136 DIKGANILLTDNGHVKLADFGVS-----AQITATIAKR-KSFIGTPYWMAPEVAAVERKG 189
Query: 425 GYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPD--HFSENAADF 482
GY + D+W++G T E+A +PP+ + M A+F + P L D +S + F
Sbjct: 190 GYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHF 249
Query: 483 VRMCLTRDQHERPSALQLLKHSFL 506
V+M LT++ +RP+A +LL+H F+
Sbjct: 250 VKMALTKNPKKRPTAEKLLQHPFV 273
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 166 bits (421), Expect = 4e-41
Identities = 102/283 (36%), Positives = 155/283 (54%), Gaps = 20/283 (7%)
Query: 228 KIFSENSLKSEEPILWTKGEILGKGAYGTVYCGLTSQ-GQLIAVKQVALDTSNKLAAEKE 286
K E+SL + ++ E LG+G+YG+VY + + GQ++A+KQV + E +
Sbjct: 15 KKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPV--------ESD 66
Query: 287 YRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVPGGSISSIIN-RFGPLPEMVF 345
+++ +E+ +++ ++V Y G+ + + I ME+ GS+S II R L E
Sbjct: 67 LQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEI 126
Query: 346 CKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDM 405
+ L+G+ YLH +HRDIK N++L G KL DFG A +L M
Sbjct: 127 ATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLT--------DTM 178
Query: 406 LK--SMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGA 463
K ++ GTP+WMAPEVI E GY +DIWS+G T EMA GKPP A + M A+F I
Sbjct: 179 AKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPT 238
Query: 464 HRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFL 506
+ P+ +S+N DFV+ CL + +R +A QLL+H F+
Sbjct: 239 NPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFV 281
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 165 bits (418), Expect = 8e-41
Identities = 97/264 (36%), Positives = 144/264 (54%), Gaps = 18/264 (6%)
Query: 249 LGKGAYGTVYCGLTSQ-GQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVA 307
+G G YG VY G+L AVK + L+ + ++ +Q+E+ ++K KH NIVA
Sbjct: 26 VGSGTYGDVYKARNVHTGELAAVKIIKLEPGD------DFSLIQQEIFMVKECKHCNIVA 79
Query: 308 YLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENCVVHR 367
Y G+ L + I ME+ GGS+ I + GPL E+ ++ LQG+AYLH +HR
Sbjct: 80 YFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHR 139
Query: 368 DIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVI---NES 424
DIKG N++L G +KL DFG A ++ KS GTPYWMAPEV
Sbjct: 140 DIKGANILLTDHGDVKLADFGVAAKIT------ATIAKRKSFIGTPYWMAPEVAAVEKNG 193
Query: 425 GYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPD--HFSENAADF 482
GY + DIW++G T E+ +PP+ + M A+F + P L D +S +F
Sbjct: 194 GYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNF 253
Query: 483 VRMCLTRDQHERPSALQLLKHSFL 506
V++ LT++ +RP+A +LL H+F+
Sbjct: 254 VKIALTKNPKKRPTAERLLTHTFV 277
>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 165 bits (418), Expect = 8e-41
Identities = 97/264 (36%), Positives = 144/264 (54%), Gaps = 18/264 (6%)
Query: 249 LGKGAYGTVYCGLTSQ-GQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVA 307
+G G YG VY G+L AVK + L+ + ++ +Q+E+ ++K KH NIVA
Sbjct: 26 VGSGTYGDVYKARNVHTGELAAVKIIKLEPGD------DFSLIQQEIFMVKECKHCNIVA 79
Query: 308 YLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENCVVHR 367
Y G+ L + I ME+ GGS+ I + GPL E+ ++ LQG+AYLH +HR
Sbjct: 80 YFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHR 139
Query: 368 DIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVI---NES 424
DIKG N++L G +KL DFG A ++ KS GTPYWMAPEV
Sbjct: 140 DIKGANILLTDHGDVKLADFGVAAKIT------ATIAKRKSFIGTPYWMAPEVAAVEKNG 193
Query: 425 GYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPD--HFSENAADF 482
GY + DIW++G T E+ +PP+ + M A+F + P L D +S +F
Sbjct: 194 GYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNF 253
Query: 483 VRMCLTRDQHERPSALQLLKHSFL 506
V++ LT++ +RP+A +LL H+F+
Sbjct: 254 VKIALTKNPKKRPTAERLLTHTFV 277
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 164 bits (415), Expect = 2e-40
Identities = 102/286 (35%), Positives = 158/286 (55%), Gaps = 20/286 (6%)
Query: 228 KIFSENSLKSEEPILWTKGEILGKGAYGTVYCGLTSQ-GQLIAVKQVALDTSNKLAAEKE 286
K SE+SL + ++ E LG+G+YG+V+ + + GQ++A+KQV + E +
Sbjct: 12 KKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV--------ESD 63
Query: 287 YRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVPGGSISSIIN-RFGPLPEMVF 345
+++ +E+ +++ +V Y G+ + + I ME+ GS+S II R L E
Sbjct: 64 LQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEI 123
Query: 346 CKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDM 405
K L+G+ YLH +HRDIK N++L G KL DFG A +L M
Sbjct: 124 ATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLT--------DTM 175
Query: 406 LK--SMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGA 463
K ++ GTP+WMAPEVI E GY +DIWS+G T EMA GKPP A + M A+F I
Sbjct: 176 AKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPT 235
Query: 464 HRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFLERS 509
+ P+ +S++ DFV+ CL ++ +R +A QLL+H F++ +
Sbjct: 236 NPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNA 281
>gi|4759208 TAO kinase 2 isoform 1 [Homo sapiens]
Length = 1049
Score = 160 bits (405), Expect = 3e-39
Identities = 101/283 (35%), Positives = 158/283 (55%), Gaps = 20/283 (7%)
Query: 231 SENSLKSEEPILWTKGEILGKGAYGTVYCGL-TSQGQLIAVKQVALDTSNKLAAEKEYRK 289
+E K + L++ +G G++G VY +++A+K+++ S K + EK ++
Sbjct: 16 AELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSY--SGKQSNEK-WQD 72
Query: 290 LQEEVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYT 349
+ +EV L+ L+H N + Y G L+E+T + ME+ G + + PL E+ T
Sbjct: 73 IIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVT 132
Query: 350 KQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSM 409
LQG+AYLH + ++HRD+K N++L G++KL DFG A +A A S
Sbjct: 133 HGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPA----------NSF 182
Query: 410 HGTPYWMAPEVI---NESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRG 466
GTPYWMAPEVI +E Y K D+WS+G T E+A KPPL +M+ M+A+++I +
Sbjct: 183 VGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNES 242
Query: 467 LMPPLPD-HFSENAADFVRMCLTRDQHERPSALQLLKHSFLER 508
P L H+SE +FV CL + +RP++ LLKH F+ R
Sbjct: 243 --PVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLR 283
>gi|45505130 TAO kinase 2 isoform 2 [Homo sapiens]
Length = 1235
Score = 160 bits (405), Expect = 3e-39
Identities = 101/283 (35%), Positives = 158/283 (55%), Gaps = 20/283 (7%)
Query: 231 SENSLKSEEPILWTKGEILGKGAYGTVYCGL-TSQGQLIAVKQVALDTSNKLAAEKEYRK 289
+E K + L++ +G G++G VY +++A+K+++ S K + EK ++
Sbjct: 16 AELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSY--SGKQSNEK-WQD 72
Query: 290 LQEEVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYT 349
+ +EV L+ L+H N + Y G L+E+T + ME+ G + + PL E+ T
Sbjct: 73 IIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVT 132
Query: 350 KQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSM 409
LQG+AYLH + ++HRD+K N++L G++KL DFG A +A A S
Sbjct: 133 HGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPA----------NSF 182
Query: 410 HGTPYWMAPEVI---NESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRG 466
GTPYWMAPEVI +E Y K D+WS+G T E+A KPPL +M+ M+A+++I +
Sbjct: 183 VGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNES 242
Query: 467 LMPPLPD-HFSENAADFVRMCLTRDQHERPSALQLLKHSFLER 508
P L H+SE +FV CL + +RP++ LLKH F+ R
Sbjct: 243 --PVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLR 283
>gi|32483399 p21-activated kinase 2 [Homo sapiens]
Length = 524
Score = 159 bits (402), Expect = 6e-39
Identities = 101/313 (32%), Positives = 164/313 (52%), Gaps = 21/313 (6%)
Query: 196 SHMKYSGRSIKRHSSGLRIYDREEKFLISNEKKIFSENSLKSEEPILWTKGEILGKGAYG 255
SH+ + +S+ + ++ D E ++ + I S K + +T+ E +G+GA G
Sbjct: 209 SHVDGAAKSLDKQKKKTKMTDEE---IMEKLRTIVSIGDPKKK----YTRYEKIGQGASG 261
Query: 256 TVYCGL-TSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQ 314
TV+ + GQ +A+KQ+ L K KE + E+ ++K LK+ NIV +L + L
Sbjct: 262 TVFTATDVALGQEVAIKQINLQKQPK----KEL--IINEILVMKELKNPNIVNFLDSYLV 315
Query: 315 ENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNV 374
+ + + ME++ GGS++ ++ + E ++ LQ + +LH N V+HRDIK +NV
Sbjct: 316 GDELFVVMEYLAGGSLTDVVTETC-MDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNV 374
Query: 375 MLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWS 434
+L G +KL DFG ++ +M GTPYWMAPEV+ YG K DIWS
Sbjct: 375 LLGMEGSVKLTDFGFCAQIT------PEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWS 428
Query: 435 IGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHER 494
+G EM G+PP + + + A++ I + P+ S DF+ CL D +R
Sbjct: 429 LGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKR 488
Query: 495 PSALQLLKHSFLE 507
SA +LL+H FL+
Sbjct: 489 GSAKELLQHPFLK 501
>gi|45439370 TAO kinase 1 [Homo sapiens]
Length = 1001
Score = 159 bits (402), Expect = 6e-39
Identities = 100/283 (35%), Positives = 158/283 (55%), Gaps = 20/283 (7%)
Query: 231 SENSLKSEEPILWTKGEILGKGAYGTVYCGLTSQ-GQLIAVKQVALDTSNKLAAEKEYRK 289
+E K + L+T +G G++G VY + +++A+K+++ S K + EK ++
Sbjct: 16 AELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSY--SGKQSTEK-WQD 72
Query: 290 LQEEVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYT 349
+ +EV L+ +KH N + Y G L+E+T + ME+ G + + PL E+ T
Sbjct: 73 IIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAIT 132
Query: 350 KQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSM 409
LQG+AYLH + ++HRDIK N++L G +KL DFG A + A S
Sbjct: 133 HGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPA----------NSF 182
Query: 410 HGTPYWMAPEVI---NESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRG 466
GTPYWMAPEVI +E Y K D+WS+G T E+A KPPL +M+ M+A+++I +
Sbjct: 183 VGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNES 242
Query: 467 LMPPL-PDHFSENAADFVRMCLTRDQHERPSALQLLKHSFLER 508
P L + +S+ +FV CL + +RP++ +LLKH F+ R
Sbjct: 243 --PTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLR 283
>gi|148746218 TAO kinase 3 [Homo sapiens]
Length = 898
Score = 159 bits (402), Expect = 6e-39
Identities = 96/265 (36%), Positives = 149/265 (56%), Gaps = 20/265 (7%)
Query: 249 LGKGAYGTVYCGLTSQ-GQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVA 307
+G G++G VY + +++A+K+++ S K EK ++ + +EV L+ LKH N +
Sbjct: 30 IGHGSFGAVYFATNAHTSEVVAIKKMSY--SGKQTHEK-WQDILKEVKFLRQLKHPNTIE 86
Query: 308 YLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENCVVHR 367
Y G L+E+T + ME+ G + + PL E+ T L G+AYLH + ++HR
Sbjct: 87 YKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALHGLAYLHSHALIHR 146
Query: 368 DIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVI---NES 424
DIK N++L G +KL DFG A + A S GTPYWMAPEVI +E
Sbjct: 147 DIKAGNILLTEPGQVKLADFGSASMASPA----------NSFVGTPYWMAPEVILAMDEG 196
Query: 425 GYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPL-PDHFSENAADFV 483
Y K DIWS+G T E+A KPPL +M+ M+A+++I + P L + ++++ FV
Sbjct: 197 QYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDS--PTLQSNEWTDSFRRFV 254
Query: 484 RMCLTRDQHERPSALQLLKHSFLER 508
CL + ERP++ +LL+H F+ R
Sbjct: 255 DYCLQKIPQERPTSAELLRHDFVRR 279
>gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens]
Length = 559
Score = 158 bits (399), Expect = 1e-38
Identities = 123/414 (29%), Positives = 200/414 (48%), Gaps = 37/414 (8%)
Query: 103 EKNLINSSLQEWAQAHAVSHPNEIETVELRKKKLTMRPLVLQKE---ESSRELCNVNLGF 159
+K + +S + A + +HP+ +T + + P V ++E E E N
Sbjct: 150 QKYMSFTSGDKSAHGYIAAHPSSTKTAS----EPPLAPPVSEEEDEEEEEEEDENEPPPV 205
Query: 160 LLPR-----SCLELNISKSVTREDAPHFLKEQQRKSEEFSTSHMKYSGRSIKRHSSGLRI 214
+ PR S ++ +S+ P+ KE S E + S Y +R S ++
Sbjct: 206 IAPRPEHTKSIYTRSVVESIASPAVPN--KEVTPPSAENANSSTLYRNTDRQRKKS--KM 261
Query: 215 YDREEKFLISNEKKIFSENSLKSEEPILWTKGEILGKGAYGTVYCGLT-SQGQLIAVKQV 273
D E ++ + I S K + +T+ E +G+GA GTVY L + GQ +A+KQ+
Sbjct: 262 TDEE---ILEKLRSIVSVGDPKKK----YTRFEKIGQGASGTVYTALDIATGQEVAIKQM 314
Query: 274 ALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVPGGSISSI 333
L K KE + E+ +++ K+ NIV YL + L + + + ME++ GGS++ +
Sbjct: 315 NLQQQPK----KEL--IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDV 368
Query: 334 INRFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRL 393
+ + E ++ LQ + +LH N V+HRDIK +N++L G +KL DFG ++
Sbjct: 369 VTETC-MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQI 427
Query: 394 AWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMD 453
+M GTPYWMAPEV+ YG K DIWS+G EM G+PP + +
Sbjct: 428 T------PEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNEN 481
Query: 454 RMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFLE 507
+ A++ I + P+ S DF+ CL D R SA +LL+H FL+
Sbjct: 482 PLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLK 535
>gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens]
Length = 565
Score = 158 bits (399), Expect = 1e-38
Identities = 123/414 (29%), Positives = 200/414 (48%), Gaps = 37/414 (8%)
Query: 103 EKNLINSSLQEWAQAHAVSHPNEIETVELRKKKLTMRPLVLQKE---ESSRELCNVNLGF 159
+K + +S + A + +HP+ +T + + P V ++E E E N
Sbjct: 156 QKYMSFTSGDKSAHGYIAAHPSSTKTAS----EPPLAPPVSEEEDEEEEEEEDENEPPPV 211
Query: 160 LLPR-----SCLELNISKSVTREDAPHFLKEQQRKSEEFSTSHMKYSGRSIKRHSSGLRI 214
+ PR S ++ +S+ P+ KE S E + S Y +R S ++
Sbjct: 212 IAPRPEHTKSIYTRSVVESIASPAVPN--KEVTPPSAENANSSTLYRNTDRQRKKS--KM 267
Query: 215 YDREEKFLISNEKKIFSENSLKSEEPILWTKGEILGKGAYGTVYCGLT-SQGQLIAVKQV 273
D E ++ + I S K + +T+ E +G+GA GTVY L + GQ +A+KQ+
Sbjct: 268 TDEE---ILEKLRSIVSVGDPKKK----YTRFEKIGQGASGTVYTALDIATGQEVAIKQM 320
Query: 274 ALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVPGGSISSI 333
L K KE + E+ +++ K+ NIV YL + L + + + ME++ GGS++ +
Sbjct: 321 NLQQQPK----KEL--IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDV 374
Query: 334 INRFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRL 393
+ + E ++ LQ + +LH N V+HRDIK +N++L G +KL DFG ++
Sbjct: 375 VTETC-MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQI 433
Query: 394 AWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMD 453
+M GTPYWMAPEV+ YG K DIWS+G EM G+PP + +
Sbjct: 434 T------PEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNEN 487
Query: 454 RMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFLE 507
+ A++ I + P+ S DF+ CL D R SA +LL+H FL+
Sbjct: 488 PLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLK 541
>gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens]
Length = 580
Score = 158 bits (399), Expect = 1e-38
Identities = 123/414 (29%), Positives = 200/414 (48%), Gaps = 37/414 (8%)
Query: 103 EKNLINSSLQEWAQAHAVSHPNEIETVELRKKKLTMRPLVLQKE---ESSRELCNVNLGF 159
+K + +S + A + +HP+ +T + + P V ++E E E N
Sbjct: 171 QKYMSFTSGDKSAHGYIAAHPSSTKTAS----EPPLAPPVSEEEDEEEEEEEDENEPPPV 226
Query: 160 LLPR-----SCLELNISKSVTREDAPHFLKEQQRKSEEFSTSHMKYSGRSIKRHSSGLRI 214
+ PR S ++ +S+ P+ KE S E + S Y +R S ++
Sbjct: 227 IAPRPEHTKSIYTRSVVESIASPAVPN--KEVTPPSAENANSSTLYRNTDRQRKKS--KM 282
Query: 215 YDREEKFLISNEKKIFSENSLKSEEPILWTKGEILGKGAYGTVYCGLT-SQGQLIAVKQV 273
D E ++ + I S K + +T+ E +G+GA GTVY L + GQ +A+KQ+
Sbjct: 283 TDEE---ILEKLRSIVSVGDPKKK----YTRFEKIGQGASGTVYTALDIATGQEVAIKQM 335
Query: 274 ALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVPGGSISSI 333
L K KE + E+ +++ K+ NIV YL + L + + + ME++ GGS++ +
Sbjct: 336 NLQQQPK----KEL--IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDV 389
Query: 334 INRFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRL 393
+ + E ++ LQ + +LH N V+HRDIK +N++L G +KL DFG ++
Sbjct: 390 VTETC-MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQI 448
Query: 394 AWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMD 453
+M GTPYWMAPEV+ YG K DIWS+G EM G+PP + +
Sbjct: 449 T------PEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNEN 502
Query: 454 RMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFLE 507
+ A++ I + P+ S DF+ CL D R SA +LL+H FL+
Sbjct: 503 PLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLK 556
>gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 158 bits (399), Expect = 1e-38
Identities = 123/414 (29%), Positives = 200/414 (48%), Gaps = 37/414 (8%)
Query: 103 EKNLINSSLQEWAQAHAVSHPNEIETVELRKKKLTMRPLVLQKE---ESSRELCNVNLGF 159
+K + +S + A + +HP+ +T + + P V ++E E E N
Sbjct: 135 QKYMSFTSGDKSAHGYIAAHPSSTKTAS----EPPLAPPVSEEEDEEEEEEEDENEPPPV 190
Query: 160 LLPR-----SCLELNISKSVTREDAPHFLKEQQRKSEEFSTSHMKYSGRSIKRHSSGLRI 214
+ PR S ++ +S+ P+ KE S E + S Y +R S ++
Sbjct: 191 IAPRPEHTKSIYTRSVVESIASPAVPN--KEVTPPSAENANSSTLYRNTDRQRKKS--KM 246
Query: 215 YDREEKFLISNEKKIFSENSLKSEEPILWTKGEILGKGAYGTVYCGLT-SQGQLIAVKQV 273
D E ++ + I S K + +T+ E +G+GA GTVY L + GQ +A+KQ+
Sbjct: 247 TDEE---ILEKLRSIVSVGDPKKK----YTRFEKIGQGASGTVYTALDIATGQEVAIKQM 299
Query: 274 ALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVPGGSISSI 333
L K KE + E+ +++ K+ NIV YL + L + + + ME++ GGS++ +
Sbjct: 300 NLQQQPK----KEL--IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDV 353
Query: 334 INRFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRL 393
+ + E ++ LQ + +LH N V+HRDIK +N++L G +KL DFG ++
Sbjct: 354 VTETC-MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQI 412
Query: 394 AWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMD 453
+M GTPYWMAPEV+ YG K DIWS+G EM G+PP + +
Sbjct: 413 T------PEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNEN 466
Query: 454 RMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFLE 507
+ A++ I + P+ S DF+ CL D R SA +LL+H FL+
Sbjct: 467 PLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLK 520
>gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 158 bits (399), Expect = 1e-38
Identities = 123/414 (29%), Positives = 200/414 (48%), Gaps = 37/414 (8%)
Query: 103 EKNLINSSLQEWAQAHAVSHPNEIETVELRKKKLTMRPLVLQKE---ESSRELCNVNLGF 159
+K + +S + A + +HP+ +T + + P V ++E E E N
Sbjct: 135 QKYMSFTSGDKSAHGYIAAHPSSTKTAS----EPPLAPPVSEEEDEEEEEEEDENEPPPV 190
Query: 160 LLPR-----SCLELNISKSVTREDAPHFLKEQQRKSEEFSTSHMKYSGRSIKRHSSGLRI 214
+ PR S ++ +S+ P+ KE S E + S Y +R S ++
Sbjct: 191 IAPRPEHTKSIYTRSVVESIASPAVPN--KEVTPPSAENANSSTLYRNTDRQRKKS--KM 246
Query: 215 YDREEKFLISNEKKIFSENSLKSEEPILWTKGEILGKGAYGTVYCGLT-SQGQLIAVKQV 273
D E ++ + I S K + +T+ E +G+GA GTVY L + GQ +A+KQ+
Sbjct: 247 TDEE---ILEKLRSIVSVGDPKKK----YTRFEKIGQGASGTVYTALDIATGQEVAIKQM 299
Query: 274 ALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVPGGSISSI 333
L K KE + E+ +++ K+ NIV YL + L + + + ME++ GGS++ +
Sbjct: 300 NLQQQPK----KEL--IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDV 353
Query: 334 INRFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRL 393
+ + E ++ LQ + +LH N V+HRDIK +N++L G +KL DFG ++
Sbjct: 354 VTETC-MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQI 412
Query: 394 AWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMD 453
+M GTPYWMAPEV+ YG K DIWS+G EM G+PP + +
Sbjct: 413 T------PEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNEN 466
Query: 454 RMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFLE 507
+ A++ I + P+ S DF+ CL D R SA +LL+H FL+
Sbjct: 467 PLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLK 520
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.132 0.389
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,444,429
Number of Sequences: 37866
Number of extensions: 926885
Number of successful extensions: 5046
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 712
Number of HSP's successfully gapped in prelim test: 114
Number of HSP's that attempted gapping in prelim test: 2543
Number of HSP's gapped (non-prelim): 1073
length of query: 510
length of database: 18,247,518
effective HSP length: 107
effective length of query: 403
effective length of database: 14,195,856
effective search space: 5720929968
effective search space used: 5720929968
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.