Search of human proteins with 62122952

Search of human proteins with 62122952

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|62122952 DCN1, defective in cullin neddylation 1, domain
containing 2 [Homo sapiens]
         (259 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|62122952 DCN1, defective in cullin neddylation 1, domain cont...   535   e-152
gi|36030883 RP42 homolog [Homo sapiens]                               438   e-123
gi|27735047 DCN1, defective in cullin neddylation 1, domain cont...   171   4e-43
gi|94536778 DCN1, defective in cullin neddylation 1, domain cont...   141   5e-34
gi|14150015 DCN1, defective in cullin neddylation 1, domain cont...   140   8e-34
gi|94536780 DCN1, defective in cullin neddylation 1, domain cont...   114   8e-26
gi|169167220 PREDICTED: hypothetical protein LOC54553 [Homo sapi...    32   0.55 
gi|169166916 PREDICTED: hypothetical protein LOC54553 [Homo sapi...    32   0.55 
gi|169166344 PREDICTED: hypothetical protein LOC54553 [Homo sapi...    32   0.55 
gi|62821790 leucine zipper protein 2 [Homo sapiens]                    32   0.55 
gi|63252863 BTB (POZ) domain containing 12 [Homo sapiens]              29   4.7  
gi|117968420 NUF2, NDC80 kinetochore complex component [Homo sap...    28   6.1  
gi|117968353 NUF2, NDC80 kinetochore complex component [Homo sap...    28   6.1  

>gi|62122952 DCN1, defective in cullin neddylation 1, domain
           containing 2 [Homo sapiens]
          Length = 259

 Score =  535 bits (1379), Expect = e-152
 Identities = 259/259 (100%), Positives = 259/259 (100%)

Query: 1   MHKLKSSQKDKVRQFMACTQAGERTAIYCLTQNEWRLDEATDSFFQNPDSLHRESMRNAV 60
           MHKLKSSQKDKVRQFMACTQAGERTAIYCLTQNEWRLDEATDSFFQNPDSLHRESMRNAV
Sbjct: 1   MHKLKSSQKDKVRQFMACTQAGERTAIYCLTQNEWRLDEATDSFFQNPDSLHRESMRNAV 60

Query: 61  DKKKLERLYGRYKDPQDENKIGVDGIQQFCDDLSLDPASISVLVIAWKFRAATQCEFSRK 120
           DKKKLERLYGRYKDPQDENKIGVDGIQQFCDDLSLDPASISVLVIAWKFRAATQCEFSRK
Sbjct: 61  DKKKLERLYGRYKDPQDENKIGVDGIQQFCDDLSLDPASISVLVIAWKFRAATQCEFSRK 120

Query: 121 EFLDGMTELGCDSMEKLKALLPRLEQELKDTAKFKDFYQFTFTFAKNPGQKGLDLEMAVA 180
           EFLDGMTELGCDSMEKLKALLPRLEQELKDTAKFKDFYQFTFTFAKNPGQKGLDLEMAVA
Sbjct: 121 EFLDGMTELGCDSMEKLKALLPRLEQELKDTAKFKDFYQFTFTFAKNPGQKGLDLEMAVA 180

Query: 181 YWKLVLSGRFKFLDLWNTFLMEHHKRSIPRDTWNLLLDFGNMIADDMSNYDEEGAWPVLI 240
           YWKLVLSGRFKFLDLWNTFLMEHHKRSIPRDTWNLLLDFGNMIADDMSNYDEEGAWPVLI
Sbjct: 181 YWKLVLSGRFKFLDLWNTFLMEHHKRSIPRDTWNLLLDFGNMIADDMSNYDEEGAWPVLI 240

Query: 241 DDFVEYARPVVTGGKRSLF 259
           DDFVEYARPVVTGGKRSLF
Sbjct: 241 DDFVEYARPVVTGGKRSLF 259


>gi|36030883 RP42 homolog [Homo sapiens]
          Length = 259

 Score =  438 bits (1127), Expect = e-123
 Identities = 201/255 (78%), Positives = 234/255 (91%)

Query: 1   MHKLKSSQKDKVRQFMACTQAGERTAIYCLTQNEWRLDEATDSFFQNPDSLHRESMRNAV 60
           M+KLKSSQKDKVRQFM  TQ+ E+TA+ CL+QN+W+LD ATD+FFQNP+   RES++ ++
Sbjct: 1   MNKLKSSQKDKVRQFMIFTQSSEKTAVSCLSQNDWKLDVATDNFFQNPELYIRESVKGSL 60

Query: 61  DKKKLERLYGRYKDPQDENKIGVDGIQQFCDDLSLDPASISVLVIAWKFRAATQCEFSRK 120
           D+KKLE+LY RYKDPQDENKIG+DGIQQFCDDL+LDPASISVL+IAWKFRAATQCEFS++
Sbjct: 61  DRKKLEQLYNRYKDPQDENKIGIDGIQQFCDDLALDPASISVLIIAWKFRAATQCEFSKQ 120

Query: 121 EFLDGMTELGCDSMEKLKALLPRLEQELKDTAKFKDFYQFTFTFAKNPGQKGLDLEMAVA 180
           EF+DGMTELGCDS+EKLKA +P++EQELK+  +FKDFYQFTF FAKNPGQKGLDLEMA+A
Sbjct: 121 EFMDGMTELGCDSIEKLKAQIPKMEQELKEPGRFKDFYQFTFNFAKNPGQKGLDLEMAIA 180

Query: 181 YWKLVLSGRFKFLDLWNTFLMEHHKRSIPRDTWNLLLDFGNMIADDMSNYDEEGAWPVLI 240
           YW LVL+GRFKFLDLWN FL+EHHKRSIP+DTWNLLLDF  MIADDMSNYDEEGAWPVLI
Sbjct: 181 YWNLVLNGRFKFLDLWNKFLLEHHKRSIPKDTWNLLLDFSTMIADDMSNYDEEGAWPVLI 240

Query: 241 DDFVEYARPVVTGGK 255
           DDFVE+ARP + G K
Sbjct: 241 DDFVEFARPQIAGTK 255


>gi|27735047 DCN1, defective in cullin neddylation 1, domain
           containing 3 [Homo sapiens]
          Length = 304

 Score =  171 bits (434), Expect = 4e-43
 Identities = 92/201 (45%), Positives = 126/201 (62%), Gaps = 8/201 (3%)

Query: 53  RESMRNAVDK--KKLERLYGRYKDPQDENKIGVDGIQQFCDDLSLDPASISVLVIAWKFR 110
           RES  NA +   ++LE L+ RYKD + E+ I  +G+++FC+DL +DP    VL++AWKF+
Sbjct: 77  RESKSNAEESSLQRLEELFRRYKDER-EDAILEEGMERFCNDLCVDPTEFRVLLLAWKFQ 135

Query: 111 AATQCEFSRKEFLDGMTELGCDSMEKLKALLPRLEQELKDTAKFKDFYQFTFTFA--KNP 168
           AAT C+F+RKEF DG   +  DS++ + A  P L  E K   KFKD Y+FTF F      
Sbjct: 136 AATMCKFTRKEFFDGCKAISADSIDGICARFPSLLTEAKQEDKFKDLYRFTFQFGLDSEE 195

Query: 169 GQKGLDLEMAVAYWKLVLS-GRFKFLDLWNTFLMEHHK--RSIPRDTWNLLLDFGNMIAD 225
           GQ+ L  E+A+A WKLV +      LD W  FL E+    + I RDTWN+ L+F  +I  
Sbjct: 196 GQRSLHREIAIALWKLVFTQNNPPVLDQWLNFLTENPSGIKGISRDTWNMFLNFTQVIGP 255

Query: 226 DMSNYDEEGAWPVLIDDFVEY 246
           D+SNY E+ AWP L D FVE+
Sbjct: 256 DLSNYSEDEAWPSLFDTFVEW 276


>gi|94536778 DCN1, defective in cullin neddylation 1, domain
           containing 4 isoform 1 [Homo sapiens]
          Length = 292

 Score =  141 bits (356), Expect = 5e-34
 Identities = 72/205 (35%), Positives = 117/205 (57%), Gaps = 2/205 (0%)

Query: 42  DSFFQNPDSLHRESMRNAVDKKKLERLYGRYKDPQDENKIGVDGIQQFCDDLSLDPASIS 101
           DS ++  DS   ++   A   K+    +  Y    D   +G +G+++FC+D+ ++P ++ 
Sbjct: 83  DSMYRKYDSTRIKTEEEAFSSKRCLEWFYEYAGTDDV--VGPEGMEKFCEDIGVEPENVV 140

Query: 102 VLVIAWKFRAATQCEFSRKEFLDGMTELGCDSMEKLKALLPRLEQELKDTAKFKDFYQFT 161
           +LV+AWK  A     F+ +E+L GMT L CD+ EKL+  L  L   L D+  FK  Y++ 
Sbjct: 141 MLVLAWKLDAQNMGYFTLQEWLKGMTSLQCDTTEKLRNTLDYLRSFLNDSTNFKLIYRYA 200

Query: 162 FTFAKNPGQKGLDLEMAVAYWKLVLSGRFKFLDLWNTFLMEHHKRSIPRDTWNLLLDFGN 221
           F FA+   Q+ LD+  A     L+L   +    +++ FL +   + I +D W  +L+F  
Sbjct: 201 FDFAREKDQRSLDINTAKCMLGLLLGKIWPLFPVFHQFLEQSKYKVINKDQWCNVLEFSR 260

Query: 222 MIADDMSNYDEEGAWPVLIDDFVEY 246
            I  D+SNYDE+GAWPVL+D+FVE+
Sbjct: 261 TINLDLSNYDEDGAWPVLLDEFVEW 285


>gi|14150015 DCN1, defective in cullin neddylation 1, domain
           containing 5 [Homo sapiens]
          Length = 237

 Score =  140 bits (354), Expect = 8e-34
 Identities = 66/186 (35%), Positives = 114/186 (61%), Gaps = 2/186 (1%)

Query: 63  KKLERLYGRYKDPQDENKIGVDGIQQFCDDLSLDPASISVLVIAWKFRAATQCEFSRKEF 122
           KK    +  Y  P +   +G +G+++FC+D+ ++P +I +LV+AWK  A +   F+++E+
Sbjct: 49  KKCLAWFYEYAGPDEV--VGPEGMEKFCEDIGVEPENIIMLVLAWKLEAESMGFFTKEEW 106

Query: 123 LDGMTELGCDSMEKLKALLPRLEQELKDTAKFKDFYQFTFTFAKNPGQKGLDLEMAVAYW 182
           L GMT L CD  EKL+     L  +L D + FK+ Y++ F FA++  Q+ LD++ A +  
Sbjct: 107 LKGMTSLQCDCTEKLQNKFDFLRSQLNDISSFKNIYRYAFDFARDKDQRSLDIDTAKSML 166

Query: 183 KLVLSGRFKFLDLWNTFLMEHHKRSIPRDTWNLLLDFGNMIADDMSNYDEEGAWPVLIDD 242
            L+L   +    ++  +L +   R + +D W  +L+F   +  D+SNYDE+GAWPVL+D+
Sbjct: 167 ALLLGRTWPLFSVFYQYLEQSKYRVMNKDQWYNVLEFSRTVHADLSNYDEDGAWPVLLDE 226

Query: 243 FVEYAR 248
           FVE+ +
Sbjct: 227 FVEWQK 232


>gi|94536780 DCN1, defective in cullin neddylation 1, domain
           containing 4 isoform 2 [Homo sapiens]
          Length = 257

 Score =  114 bits (285), Expect = 8e-26
 Identities = 65/205 (31%), Positives = 101/205 (49%), Gaps = 37/205 (18%)

Query: 42  DSFFQNPDSLHRESMRNAVDKKKLERLYGRYKDPQDENKIGVDGIQQFCDDLSLDPASIS 101
           DS ++  DS   ++   A   K+    +  Y    D   +G +G+++FC+D+ ++P ++ 
Sbjct: 83  DSMYRKYDSTRIKTEEEAFSSKRCLEWFYEYAGTDDV--VGPEGMEKFCEDIGVEPENVV 140

Query: 102 VLVIAWKFRAATQCEFSRKEFLDGMTELGCDSMEKLKALLPRLEQELKDTAKFKDFYQFT 161
           +LV+AWK  A     F+ +E+L GMT L CD+ EKL+  L  L   L D+  FK  Y++ 
Sbjct: 141 MLVLAWKLDAQNMGYFTLQEWLKGMTSLQCDTTEKLRNTLDYLRSFLNDSTNFKLIYRYA 200

Query: 162 FTFAKNPGQKGLDLEMAVAYWKLVLSGRFKFLDLWNTFLMEHHKRSIPRDTWNLLLDFGN 221
           F FA+    K                                    I +D W  +L+F  
Sbjct: 201 FDFARQSKYK-----------------------------------VINKDQWCNVLEFSR 225

Query: 222 MIADDMSNYDEEGAWPVLIDDFVEY 246
            I  D+SNYDE+GAWPVL+D+FVE+
Sbjct: 226 TINLDLSNYDEDGAWPVLLDEFVEW 250


>gi|169167220 PREDICTED: hypothetical protein LOC54553 [Homo
           sapiens]
          Length = 142

 Score = 32.0 bits (71), Expect = 0.55
 Identities = 23/77 (29%), Positives = 35/77 (45%), Gaps = 3/77 (3%)

Query: 67  RLYGRYKDPQDENKIGVDGIQQFCDDLSLDP-ASISVLVIAWKFRAATQCEFSRKEFLDG 125
           RLYGR +  + + +  V+   +   DL+ DP A+     +A  F A   C F RKE    
Sbjct: 29  RLYGRVRTEERKGRSRVE--PKLPPDLTPDPRAAWRAWSVAVSFGAGGDCSFGRKEEAQA 86

Query: 126 MTELGCDSMEKLKALLP 142
            +   C    K++ L P
Sbjct: 87  ASSGSCAHHPKVRHLAP 103


>gi|169166916 PREDICTED: hypothetical protein LOC54553 [Homo
           sapiens]
          Length = 142

 Score = 32.0 bits (71), Expect = 0.55
 Identities = 23/77 (29%), Positives = 35/77 (45%), Gaps = 3/77 (3%)

Query: 67  RLYGRYKDPQDENKIGVDGIQQFCDDLSLDP-ASISVLVIAWKFRAATQCEFSRKEFLDG 125
           RLYGR +  + + +  V+   +   DL+ DP A+     +A  F A   C F RKE    
Sbjct: 29  RLYGRVRTEERKGRSRVE--PKLPPDLTPDPRAAWRAWSVAVSFGAGGDCSFGRKEEAQA 86

Query: 126 MTELGCDSMEKLKALLP 142
            +   C    K++ L P
Sbjct: 87  ASSGSCAHHPKVRHLAP 103


>gi|169166344 PREDICTED: hypothetical protein LOC54553 [Homo
           sapiens]
          Length = 142

 Score = 32.0 bits (71), Expect = 0.55
 Identities = 23/77 (29%), Positives = 35/77 (45%), Gaps = 3/77 (3%)

Query: 67  RLYGRYKDPQDENKIGVDGIQQFCDDLSLDP-ASISVLVIAWKFRAATQCEFSRKEFLDG 125
           RLYGR +  + + +  V+   +   DL+ DP A+     +A  F A   C F RKE    
Sbjct: 29  RLYGRVRTEERKGRSRVE--PKLPPDLTPDPRAAWRAWSVAVSFGAGGDCSFGRKEEAQA 86

Query: 126 MTELGCDSMEKLKALLP 142
            +   C    K++ L P
Sbjct: 87  ASSGSCAHHPKVRHLAP 103


>gi|62821790 leucine zipper protein 2 [Homo sapiens]
          Length = 346

 Score = 32.0 bits (71), Expect = 0.55
 Identities = 17/51 (33%), Positives = 29/51 (56%)

Query: 116 EFSRKEFLDGMTELGCDSMEKLKALLPRLEQELKDTAKFKDFYQFTFTFAK 166
           E S K  +  + ELG    E++K+L   L+ +LK+T++  + +Q T  F K
Sbjct: 66  EQSAKTDVQKLLELGQKQREEMKSLQEALQNQLKETSEKAEKHQATINFLK 116


>gi|63252863 BTB (POZ) domain containing 12 [Homo sapiens]
          Length = 1834

 Score = 28.9 bits (63), Expect = 4.7
 Identities = 20/92 (21%), Positives = 40/92 (43%), Gaps = 7/92 (7%)

Query: 79  NKIGVDGIQQFCDDLSLDPASISVLVIAWKFRAATQCEFSRKEFLDGMTELGCDSMEKLK 138
           ++ GV  +   C+ + +   S       W+ + A  CE   + F + +  +  D  E+ +
Sbjct: 775 HRFGVSELVHLCEQVPIATDSEGK---PWEEKEAENCESRAENFQELLRSMWADEEEEAE 831

Query: 139 ALLP----RLEQELKDTAKFKDFYQFTFTFAK 166
            LL       +QE  + A+ ++ Y+F  T  K
Sbjct: 832 TLLKSKDHEEDQENVNEAEMEEIYEFAATQRK 863


>gi|117968420 NUF2, NDC80 kinetochore complex component [Homo
           sapiens]
          Length = 464

 Score = 28.5 bits (62), Expect = 6.1
 Identities = 33/132 (25%), Positives = 59/132 (44%), Gaps = 24/132 (18%)

Query: 35  WRLDEATDSFFQNPDSLHRESMRNAVDKKKLERLYGRYKDPQDENKIGVDGIQQFCDDLS 94
           W+   + D   Q  ++ H+E++       KLERL     + Q+E K   DGIQ+    L+
Sbjct: 143 WQYKSSADKM-QQLNAAHQEALM------KLERLDSVPVEEQEEFKQLSDGIQELQQSLN 195

Query: 95  LDPASISVLV----------IAWKFRAATQCEF---SRKEFLDGMTELGCDSMEKLKALL 141
            D    ++++          I+ K +   + +    S KE  + +     DS EKLK   
Sbjct: 196 QDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLK--- 252

Query: 142 PRLEQELKDTAK 153
              ++++KDT +
Sbjct: 253 -NYKEKMKDTVQ 263


>gi|117968353 NUF2, NDC80 kinetochore complex component [Homo
           sapiens]
          Length = 464

 Score = 28.5 bits (62), Expect = 6.1
 Identities = 33/132 (25%), Positives = 59/132 (44%), Gaps = 24/132 (18%)

Query: 35  WRLDEATDSFFQNPDSLHRESMRNAVDKKKLERLYGRYKDPQDENKIGVDGIQQFCDDLS 94
           W+   + D   Q  ++ H+E++       KLERL     + Q+E K   DGIQ+    L+
Sbjct: 143 WQYKSSADKM-QQLNAAHQEALM------KLERLDSVPVEEQEEFKQLSDGIQELQQSLN 195

Query: 95  LDPASISVLV----------IAWKFRAATQCEF---SRKEFLDGMTELGCDSMEKLKALL 141
            D    ++++          I+ K +   + +    S KE  + +     DS EKLK   
Sbjct: 196 QDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLK--- 252

Query: 142 PRLEQELKDTAK 153
              ++++KDT +
Sbjct: 253 -NYKEKMKDTVQ 263


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.137    0.420 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,540,283
Number of Sequences: 37866
Number of extensions: 390415
Number of successful extensions: 872
Number of sequences better than 10.0: 13
Number of HSP's better than 10.0 without gapping: 7
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 861
Number of HSP's gapped (non-prelim): 14
length of query: 259
length of database: 18,247,518
effective HSP length: 100
effective length of query: 159
effective length of database: 14,460,918
effective search space: 2299285962
effective search space used: 2299285962
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.