Search of human proteins with 59889578

Search of human proteins with 59889578

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|59889578 dehydrogenase/reductase (SDR family) member 10
[Homo sapiens]
         (270 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo...   538   e-153
gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]    114   1e-25
gi|10190704 2,4-dienoyl CoA reductase 2 [Homo sapiens]                110   1e-24
gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1 [...   110   2e-24
gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]    109   2e-24
gi|40254992 carbonic reductase 4 [Homo sapiens]                       109   2e-24
gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens]       102   4e-22
gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]          100   2e-21
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ...    97   1e-20
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ...    97   1e-20
gi|83715985 hydroxysteroid (17-beta) dehydrogenase 10 isoform 2 ...    94   2e-19
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi...    94   2e-19
gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]              92   6e-19
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap...    90   2e-18
gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]        87   2e-17
gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo...    86   3e-17
gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Hom...    86   3e-17
gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Hom...    86   3e-17
gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo...    86   3e-17
gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform...    85   8e-17
gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens]     83   2e-16
gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [H...    82   6e-16
gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [H...    82   6e-16
gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [H...    82   6e-16
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo...    80   1e-15
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s...    76   3e-14
gi|150247226 retinol dehydrogenase 16 [Homo sapiens]                   75   8e-14
gi|126723191 dehydrogenase/reductase (SDR family) member 4 like ...    69   3e-12
gi|22507405 short chain dehydrogenase/reductase family 9C, membe...    69   6e-12
gi|119392083 hydroxysteroid (11-beta) dehydrogenase 2 [Homo sapi...    68   7e-12

>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
           sapiens]
          Length = 270

 Score =  538 bits (1386), Expect = e-153
 Identities = 270/270 (100%), Positives = 270/270 (100%)

Query: 1   MATGTRYAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAVFIL 60
           MATGTRYAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAVFIL
Sbjct: 1   MATGTRYAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAVFIL 60

Query: 61  CDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYT 120
           CDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYT
Sbjct: 61  CDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYT 120

Query: 121 LTKLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVN 180
           LTKLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVN
Sbjct: 121 LTKLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVN 180

Query: 181 CISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLASEANFCTG 240
           CISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLASEANFCTG
Sbjct: 181 CISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLASEANFCTG 240

Query: 241 IELLVTGGAELGYGCKASRSTPVDAPDIPS 270
           IELLVTGGAELGYGCKASRSTPVDAPDIPS
Sbjct: 241 IELLVTGGAELGYGCKASRSTPVDAPDIPS 270


>gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]
          Length = 245

 Score =  114 bits (284), Expect = 1e-25
 Identities = 81/251 (32%), Positives = 124/251 (49%), Gaps = 13/251 (5%)

Query: 6   RYAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAVFILCDVTQ 65
           R  GKV+++T   +GIG     AF   GA+V+  D +ES  + LE+  PG    + DVT+
Sbjct: 3   RLDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEK-YPGIQTRVLDVTK 61

Query: 66  EDDVKTLVSETIRRFGRLDCVVNNAG--HHPPPQRPEETSAQGFRQLLELNLLGTYTLTK 123
           +  +    +E      RLD + N AG  HH      EE   + +   + LN+   Y + K
Sbjct: 62  KKQIDQFANEV----ERLDVLFNVAGFVHHGTVLDCEE---KDWDFSMNLNVRSMYLMIK 114

Query: 124 LALP-YLRKSQGNVINISSLVGAI-GQAQAVPYVATKGAVTAMTKALALDESPYGVRVNC 181
             LP  L +  GN+IN+SS+  ++ G      Y  TK AV  +TK++A D    G+R NC
Sbjct: 115 AFLPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIRCNC 174

Query: 182 ISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLAS-EANFCTG 240
           + PG + TP  +E      +P     + +  Q  GR     E+    V+LAS E+ + TG
Sbjct: 175 VCPGTVDTPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIAMLCVYLASDESAYVTG 234

Query: 241 IELLVTGGAEL 251
             +++ GG  L
Sbjct: 235 NPVIIDGGWSL 245


>gi|10190704 2,4-dienoyl CoA reductase 2 [Homo sapiens]
          Length = 292

 Score =  110 bits (275), Expect = 1e-24
 Identities = 78/252 (30%), Positives = 128/252 (50%), Gaps = 13/252 (5%)

Query: 10  KVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAVFILC-----DVT 64
           KV  +TGGG GIG  I   F+  G   VI  +         ++L GA    C     DV 
Sbjct: 29  KVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAGATGRRCLPLSMDVR 88

Query: 65  QEDDVKTLVSETIRRFGRLDCVVN-NAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTK 123
               V   V + ++ FGR+D ++N  AG+   P      S   F+ +++++  GT+ +++
Sbjct: 89  APPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGA--LSFNAFKTVMDIDTSGTFNVSR 146

Query: 124 LALP-YLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCI 182
           +    + R   G ++NI++ +G  GQA  V   + K AV AMT+ LA++  P  +RVN +
Sbjct: 147 VLYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWGPQNIRVNSL 206

Query: 183 SPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLASE-ANFCTGI 241
           +PG I      E    +  P+A++   + A PL R+G   E+  + ++LAS  A++ TG 
Sbjct: 207 APGPI---SGTEGLRRLGGPQASLSTKVTASPLQRLGNKTEIAHSVLYLASPLASYVTGA 263

Query: 242 ELLVTGGAELGY 253
            L+  GGA L +
Sbjct: 264 VLVADGGAWLTF 275


>gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1
           [Homo sapiens]
          Length = 261

 Score =  110 bits (274), Expect = 2e-24
 Identities = 74/228 (32%), Positives = 114/228 (50%), Gaps = 18/228 (7%)

Query: 9   GKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPG-AVFILCDVTQED 67
           G V V+TGG  G+G       V  GA  V+ D   SGG A  ++L    VF   DVT E 
Sbjct: 10  GLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEK 69

Query: 68  DVKTLVSETIRRFGRLDCVVNNAGHHPPPQ-----RPEETSAQGFRQLLELNLLGTYTLT 122
           DV+T ++    +FGR+D  VN AG     +     + +  + + F+++L++NL+GT+ + 
Sbjct: 70  DVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVI 129

Query: 123 KLALPYLRKSQ-------GNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPY 175
           +L    + +++       G +IN +S+    GQ     Y A+KG +  MT  +A D +P 
Sbjct: 130 RLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPI 189

Query: 176 GVRVNCISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAE 223
           G+RV  I+PG   TPL   L    P+         +  P  R+G PAE
Sbjct: 190 GIRVMTIAPGLFGTPLLTSL----PEKVCNFLASQVPFP-SRLGDPAE 232


>gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]
          Length = 303

 Score =  109 bits (273), Expect = 2e-24
 Identities = 83/255 (32%), Positives = 131/255 (51%), Gaps = 17/255 (6%)

Query: 9   GKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKD----ESGGRALEQELPGA-----VFI 59
           G+V +VTGG  GIG  IV+  +  G+ VVI  +     +S    L+  LP       + I
Sbjct: 18  GQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVIPI 77

Query: 60  LCDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTY 119
            C++  E++V  LV  T+  FG+++ +VNN G        E  S++G+  +LE NL GT+
Sbjct: 78  QCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPA-EHISSKGWHAVLETNLTGTF 136

Query: 120 TLTKLALP-YLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVR 178
            + K     ++++  G+++NI     A G   AV   A +  V  +TK+LAL+ +  G+R
Sbjct: 137 YMCKAVYSSWMKEHGGSIVNIIVPTKA-GFPLAVHSGAARAGVYNLTKSLALEWACSGIR 195

Query: 179 VNCISPGNIWTPLWEELAALMPDPRATIREGMLAQ-PLGRMGQPAEVGAAAVFLAS-EAN 236
           +NC++PG I++    E          +  EG   + P  R+G P EV +   FL S  A+
Sbjct: 196 INCVAPGVIYSQTAVENYGSWGQ---SFFEGSFQKIPAKRIGVPEEVSSVVCFLLSPAAS 252

Query: 237 FCTGIELLVTGGAEL 251
           F TG  + V GG  L
Sbjct: 253 FITGQSVDVDGGRSL 267


>gi|40254992 carbonic reductase 4 [Homo sapiens]
          Length = 237

 Score =  109 bits (273), Expect = 2e-24
 Identities = 78/246 (31%), Positives = 125/246 (50%), Gaps = 17/246 (6%)

Query: 10  KVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGA-VFILCDVTQEDD 68
           KV  V GG RGIG  + +     G R+ +  ++  G +A   +L G  +   CDV +E D
Sbjct: 3   KVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHD 62

Query: 69  VKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLALPY 128
           V+    E  +  GR++ +VN AG +        T  +     L  NLLG+    K A+  
Sbjct: 63  VQNTFEELEKHLGRVNFLVNAAGINRDGLLVR-TKTEDMVSQLHTNLLGSMLTCKAAMRT 121

Query: 129 LRKSQG-NVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGNI 187
           + + QG +++N+ S+VG  G +    Y A+KG +   ++ALA + +   +RVN ++PG +
Sbjct: 122 MIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAPGFV 181

Query: 188 WTPLWEELAALMPDPRATIREGMLAQ--PLGRMGQPAEVGAAAVFLASEANFCTGIELLV 245
            T + ++L           +E  L +  PLGR G+  EV  A VFL  E+ + TG  L+V
Sbjct: 182 HTDMTKDL-----------KEEHLKKNIPLGRFGETIEVAHAVVFLL-ESPYITGHVLVV 229

Query: 246 TGGAEL 251
            GG +L
Sbjct: 230 DGGLQL 235


>gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens]
          Length = 335

 Score =  102 bits (254), Expect = 4e-22
 Identities = 79/255 (30%), Positives = 124/255 (48%), Gaps = 16/255 (6%)

Query: 7   YAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAV-----FILC 61
           + GKV  +TGGG G+G G+     + GA+ VI  +     +A  +++          I C
Sbjct: 57  FQGKVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQC 116

Query: 62  DVTQEDDVKTLVSETIRRFGRLDCVVNNA-GHHPPPQRPEETSAQGFRQLLELNLLGTYT 120
           DV   D V+  VSE I+  G  + V+NNA G+   P   E  S   ++ + ++ L GT  
Sbjct: 117 DVRDPDMVQNTVSELIKVAGHPNIVINNAAGNFISPT--ERLSPNAWKTITDIVLNGTAF 174

Query: 121 LTKLALPYLRKSQGNV--INISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVR 178
           +T      L K+Q     ++I+++    G    VP  + K  V AM+K+LA +   YG+R
Sbjct: 175 VTLEIGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMR 234

Query: 179 VNCISPGNIWTPLWEELAALMPDPRATIREGMLAQ-PLGRMGQPAEVGAAAVFLASE-AN 236
            N I PG    P+  + A    DP  T  + M+ + P GR+G   E+   A FL S+ A+
Sbjct: 235 FNVIQPG----PIKTKGAFSRLDPTGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYAS 290

Query: 237 FCTGIELLVTGGAEL 251
           +  G  +   GG E+
Sbjct: 291 WINGAVIKFDGGEEV 305


>gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]
          Length = 261

 Score =  100 bits (248), Expect = 2e-21
 Identities = 71/257 (27%), Positives = 118/257 (45%), Gaps = 20/257 (7%)

Query: 6   RYAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGA--------- 56
           R    + +VTG G GIG  +       GA V  CD D +  +   + L G          
Sbjct: 8   RLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRG 67

Query: 57  --VFILCDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELN 114
                  DV++    + L+ +    F R   VV +       +     S   + +++ +N
Sbjct: 68  NHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVN 127

Query: 115 LLGTYTLTKLALPYLRKS--QGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDE 172
           L GT+ +T+ A   L  +  +G++INISS+VG +G      Y A+K  V  +T+  A + 
Sbjct: 128 LKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAAREL 187

Query: 173 SPYGVRVNCISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLA 232
             +G+R N + PG I TP+ +++      P+  + +     P+G +G P +V     FLA
Sbjct: 188 GRHGIRCNSVLPGFIATPMTQKV------PQKVVDKITEMIPMGHLGDPEDVADVVAFLA 241

Query: 233 SE-ANFCTGIELLVTGG 248
           SE + + TG  + VTGG
Sbjct: 242 SEDSGYITGTSVEVTGG 258


>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
           sapiens]
          Length = 278

 Score = 97.4 bits (241), Expect = 1e-20
 Identities = 68/247 (27%), Positives = 122/247 (49%), Gaps = 10/247 (4%)

Query: 8   AGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPG----AVFILCDV 63
           A KV +VT    GIG  I R     GA VV+  + +         L G        +C V
Sbjct: 31  ANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHV 90

Query: 64  TQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTK 123
            + +D + LV+  ++  G +D +V+NA  +P      + + + + + L++N+     +TK
Sbjct: 91  GKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAPALMTK 150

Query: 124 LALPYLRKSQGNVINISSLVGAIGQAQAV-PYVATKGAVTAMTKALALDESPYGVRVNCI 182
             +P + K  G  + I S + A   +    PY  +K A+  +TK LA++ +P  +RVNC+
Sbjct: 151 AVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIRVNCL 210

Query: 183 SPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLASE-ANFCTGI 241
           +PG I T  +  +  +  +   +++E +    + R+G+P +      FL SE A++ TG 
Sbjct: 211 APGLIKTS-FSRMLWMDKEKEESMKETL---RIRRLGEPEDCAGIVSFLCSEDASYITGE 266

Query: 242 ELLVTGG 248
            ++V GG
Sbjct: 267 TVVVGGG 273


>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
           [Homo sapiens]
          Length = 266

 Score = 97.1 bits (240), Expect = 1e-20
 Identities = 65/199 (32%), Positives = 101/199 (50%), Gaps = 21/199 (10%)

Query: 9   GKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGG----RALEQELPG--AVFILCD 62
           GKV +VTG  +GIG     A +  GA+V + D +   G     AL+++      +FI CD
Sbjct: 5   GKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCD 64

Query: 63  VTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLT 122
           V  +  ++    + +  FGRLD +VNNAG           + + + + L++NL+   + T
Sbjct: 65  VADQQQLRDTFRKVVDHFGRLDILVNNAG---------VNNEKNWEKTLQINLVSVISGT 115

Query: 123 KLALPYLRKSQGN----VINISSLVGAIGQAQAVPYVATKGAVTAMTK--ALALDESPYG 176
            L L Y+ K  G     +IN+SSL G +  AQ   Y A+K  +   T+  ALA +    G
Sbjct: 116 YLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSG 175

Query: 177 VRVNCISPGNIWTPLWEEL 195
           VR+N I PG + T + E +
Sbjct: 176 VRLNAICPGFVNTAILESI 194


>gi|83715985 hydroxysteroid (17-beta) dehydrogenase 10 isoform 2
           [Homo sapiens]
          Length = 252

 Score = 93.6 bits (231), Expect = 2e-19
 Identities = 69/228 (30%), Positives = 108/228 (47%), Gaps = 27/228 (11%)

Query: 9   GKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQEL-PGAVFILCDVTQED 67
           G V V+TGG  G+G       V  GA  V+ D   SGG A  ++L    VF   DVT E 
Sbjct: 10  GLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEK 69

Query: 68  DVKTLVSETIRRFGRLDCVVNNAGHHPPP-----QRPEETSAQGFRQLLELNLLGTYTLT 122
           DV+T ++    +FGR+D  VN AG          ++ +  + + F+++L++NL+GT+ + 
Sbjct: 70  DVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVI 129

Query: 123 KLALPYLRKSQ-------GNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPY 175
           +L    + +++       G +IN +S+    GQ     Y A+KG +  MT  +A D +P 
Sbjct: 130 RLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPI 189

Query: 176 GVRVNCISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAE 223
           G+           TPL   L    P+         +  P  R+G PAE
Sbjct: 190 GL---------FGTPLLTSL----PEKVCNFLASQVPFP-SRLGDPAE 223


>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
           sapiens]
          Length = 280

 Score = 93.6 bits (231), Expect = 2e-19
 Identities = 73/245 (29%), Positives = 117/245 (47%), Gaps = 9/245 (3%)

Query: 8   AGKVVVVTGGGRGIGAGIVRAFVNSGARVVICD-KDESGGRA---LEQELPGAVFILCDV 63
           A +V VVTG   GIG  I R     GA VVI   K ++  RA   L+ E      I+C V
Sbjct: 35  ANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHV 94

Query: 64  TQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTK 123
            + +D + LV++ +   G +D +V +AG +P       TS Q + ++L +N+     L  
Sbjct: 95  GKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLS 154

Query: 124 LALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCIS 183
             LPY+   +G VI +SS+           Y  +K A+  +T+ LAL+ +P  +RVNC+ 
Sbjct: 155 QLLPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRVNCVV 214

Query: 184 PGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLAS-EANFCTGIE 242
           PG I T    + + +     +  +       L R+G+  +      FL S +A++  G  
Sbjct: 215 PGIIKT----DFSKVFHGNESLWKNFKEHHQLQRIGESEDCAGIVSFLCSPDASYVNGEN 270

Query: 243 LLVTG 247
           + V G
Sbjct: 271 IAVAG 275


>gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]
          Length = 244

 Score = 91.7 bits (226), Expect = 6e-19
 Identities = 75/245 (30%), Positives = 122/245 (49%), Gaps = 14/245 (5%)

Query: 8   AGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAVFILCDVTQED 67
           AG+ V+VTG G+GIG G V+A   +GARVV   + ++   +L +E PG   +  D+   +
Sbjct: 6   AGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWE 65

Query: 68  DVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLALP 127
             +  +       G +D +VNNA      Q   E + + F +  E+NL     ++++   
Sbjct: 66  ATERALGSV----GPVDLLVNNAA-VALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR 120

Query: 128 YL--RKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPG 185
            L  R   G ++N+SS            Y +TKGA+  +TK +AL+  P+ +RVN ++P 
Sbjct: 121 GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPT 180

Query: 186 NIWTPLWEELAALMPDPRATIREGMLAQ-PLGRMGQPAEVGAAAVFLASE-ANFCTGIEL 243
            + T + +   A   DP     + ML + PLG+  +   V  A +FL S+ +   TG  L
Sbjct: 181 VVMTSMGQ---ATWSDPHKA--KTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTL 235

Query: 244 LVTGG 248
            V GG
Sbjct: 236 PVEGG 240


>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
           sapiens]
          Length = 300

 Score = 90.1 bits (222), Expect = 2e-18
 Identities = 63/186 (33%), Positives = 95/186 (51%), Gaps = 4/186 (2%)

Query: 8   AGKVVVVTGGGRGIGAGIVRAFVNSGARVVICD-KDESGGRA---LEQELPGAVFILCDV 63
           A +V VVTG   GIG  I R     GA VVI   K ++  RA   L+ E      I+C V
Sbjct: 35  ANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHV 94

Query: 64  TQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTK 123
            + +D + LV++ +   G +D +V +AG +P       TS Q + ++L +N+     L  
Sbjct: 95  GKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLS 154

Query: 124 LALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCIS 183
             LPY+   +G VI +SS+           Y  +K A+  +T+ LAL+ +P  +RVNC+ 
Sbjct: 155 QLLPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRVNCVV 214

Query: 184 PGNIWT 189
           PG I T
Sbjct: 215 PGIIKT 220


>gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]
          Length = 260

 Score = 87.0 bits (214), Expect = 2e-17
 Identities = 70/241 (29%), Positives = 115/241 (47%), Gaps = 20/241 (8%)

Query: 6   RYAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDK-----DESGGRALEQELPGAVF-I 59
           R+  ++ +VTG   GIGA + RA V  G +VV C +     +E          PG +   
Sbjct: 8   RWRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPY 67

Query: 60  LCDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTY 119
            CD++ E+D+ ++ S    +   +D  +NNAG    P      S  G++ +  +N+L   
Sbjct: 68  RCDLSNEEDILSMFSAIRSQHSGVDICINNAG-LARPDTLLSGSTSGWKDMFNVNVLALS 126

Query: 120 TLTKLALPYLRK---SQGNVINISSLVGAIGQAQAVP--YVATKGAVTAMTKAL--ALDE 172
             T+ A   +++     G++INI+S+ G      +V   Y ATK AVTA+T+ L   L E
Sbjct: 127 ICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELRE 186

Query: 173 SPYGVRVNCISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLA 232
           +   +R  CISPG + T    +L    P+  A   E M      +  +P +V  A +++ 
Sbjct: 187 AQTHIRATCISPGVVETQFAFKLHDKDPEKAAATYEQM------KCLKPEDVAEAVIYVL 240

Query: 233 S 233
           S
Sbjct: 241 S 241


>gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo
           sapiens]
          Length = 319

 Score = 85.9 bits (211), Expect = 3e-17
 Identities = 67/225 (29%), Positives = 106/225 (47%), Gaps = 20/225 (8%)

Query: 10  KVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAV-FILCDVTQEDD 68
           K + +TG   G G    R F   G  V+     ESG  AL+ E    +  +L DVT  ++
Sbjct: 30  KYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTDPEN 89

Query: 69  VKTLVSETIRRFGR--LDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLAL 126
           VK        + G   L  ++NNAG        +  + + +R+ +E+NL G  ++T   L
Sbjct: 90  VKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISVTLNML 149

Query: 127 PYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPG- 185
           P ++K+QG VIN+SS+ G +       Y  +K AV     +L  D   +GV V+CI PG 
Sbjct: 150 PLVKKAQGRVINVSSVGGRLAIVGG-GYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGL 208

Query: 186 ---NIWTP---------LWEELAALMPDPRATIREGMLAQPLGRM 218
              N+  P         +WE+L+   PD +    EG + + L ++
Sbjct: 209 FKTNLADPVKVIEKKLAIWEQLS---PDIKQQYGEGYIEKSLDKL 250


>gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Homo
           sapiens]
          Length = 319

 Score = 85.9 bits (211), Expect = 3e-17
 Identities = 67/225 (29%), Positives = 106/225 (47%), Gaps = 20/225 (8%)

Query: 10  KVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAV-FILCDVTQEDD 68
           K + +TG   G G    R F   G  V+     ESG  AL+ E    +  +L DVT  ++
Sbjct: 30  KYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTDPEN 89

Query: 69  VKTLVSETIRRFGR--LDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLAL 126
           VK        + G   L  ++NNAG        +  + + +R+ +E+NL G  ++T   L
Sbjct: 90  VKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISVTLNML 149

Query: 127 PYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPG- 185
           P ++K+QG VIN+SS+ G +       Y  +K AV     +L  D   +GV V+CI PG 
Sbjct: 150 PLVKKAQGRVINVSSVGGRLAIVGG-GYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGL 208

Query: 186 ---NIWTP---------LWEELAALMPDPRATIREGMLAQPLGRM 218
              N+  P         +WE+L+   PD +    EG + + L ++
Sbjct: 209 FKTNLADPVKVIEKKLAIWEQLS---PDIKQQYGEGYIEKSLDKL 250


>gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Homo
           sapiens]
          Length = 319

 Score = 85.9 bits (211), Expect = 3e-17
 Identities = 67/225 (29%), Positives = 106/225 (47%), Gaps = 20/225 (8%)

Query: 10  KVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAV-FILCDVTQEDD 68
           K + +TG   G G    R F   G  V+     ESG  AL+ E    +  +L DVT  ++
Sbjct: 30  KYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTDPEN 89

Query: 69  VKTLVSETIRRFGR--LDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLAL 126
           VK        + G   L  ++NNAG        +  + + +R+ +E+NL G  ++T   L
Sbjct: 90  VKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISVTLNML 149

Query: 127 PYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPG- 185
           P ++K+QG VIN+SS+ G +       Y  +K AV     +L  D   +GV V+CI PG 
Sbjct: 150 PLVKKAQGRVINVSSVGGRLAIVGG-GYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGL 208

Query: 186 ---NIWTP---------LWEELAALMPDPRATIREGMLAQPLGRM 218
              N+  P         +WE+L+   PD +    EG + + L ++
Sbjct: 209 FKTNLADPVKVIEKKLAIWEQLS---PDIKQQYGEGYIEKSLDKL 250


>gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo
           sapiens]
          Length = 319

 Score = 85.9 bits (211), Expect = 3e-17
 Identities = 67/225 (29%), Positives = 106/225 (47%), Gaps = 20/225 (8%)

Query: 10  KVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAV-FILCDVTQEDD 68
           K + +TG   G G    R F   G  V+     ESG  AL+ E    +  +L DVT  ++
Sbjct: 30  KYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTDPEN 89

Query: 69  VKTLVSETIRRFGR--LDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLAL 126
           VK        + G   L  ++NNAG        +  + + +R+ +E+NL G  ++T   L
Sbjct: 90  VKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISVTLNML 149

Query: 127 PYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPG- 185
           P ++K+QG VIN+SS+ G +       Y  +K AV     +L  D   +GV V+CI PG 
Sbjct: 150 PLVKKAQGRVINVSSVGGRLAIVGG-GYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGL 208

Query: 186 ---NIWTP---------LWEELAALMPDPRATIREGMLAQPLGRM 218
              N+  P         +WE+L+   PD +    EG + + L ++
Sbjct: 209 FKTNLADPVKVIEKKLAIWEQLS---PDIKQQYGEGYIEKSLDKL 250


>gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 2
           [Homo sapiens]
          Length = 178

 Score = 84.7 bits (208), Expect = 8e-17
 Identities = 54/171 (31%), Positives = 86/171 (50%), Gaps = 19/171 (11%)

Query: 9   GKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGG----RALEQELPG--AVFILCD 62
           GKV +VTG  +GIG     A +  GA+V + D +   G     AL+++      +FI CD
Sbjct: 5   GKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCD 64

Query: 63  VTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLT 122
           V  +  ++    + +  FGRLD +VNNAG           + + + + L++NL+   + T
Sbjct: 65  VADQQQLRDTFRKVVDHFGRLDILVNNAG---------VNNEKNWEKTLQINLVSVISGT 115

Query: 123 KLALPYLRKSQGN----VINISSLVGAIGQAQAVPYVATKGAVTAMTKALA 169
            L L Y+ K  G     +IN+SSL G +  AQ   Y A+K  +   T++ A
Sbjct: 116 YLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAA 166


>gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens]
          Length = 387

 Score = 83.2 bits (204), Expect = 2e-16
 Identities = 60/197 (30%), Positives = 93/197 (47%), Gaps = 11/197 (5%)

Query: 10  KVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQEL---PGAVFILCDVTQE 66
           K V+VTGG  G+G  + +     G  V     +E+G  A E      P    +  D+T+ 
Sbjct: 83  KAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPGAEELRRTCSPRLSVLQMDITKP 142

Query: 67  DDVKTLVSETIRRFGR--LDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKL 124
             +K   S+         L  V+NNAG    P   E      ++Q + +N  GT  +TK 
Sbjct: 143 VQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELLLMTDYKQCMAVNFFGTVEVTKT 202

Query: 125 ALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISP 184
            LP LRKS+G ++N+SS+ G     +   Y ++K AVT  +  + L+ S +G++V  I P
Sbjct: 203 FLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLELSKWGIKVASIQP 262

Query: 185 GNIWTPL------WEEL 195
           G   T +      WE+L
Sbjct: 263 GGFLTNIAGTSDKWEKL 279


>gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
           sapiens]
          Length = 343

 Score = 81.6 bits (200), Expect = 6e-16
 Identities = 62/210 (29%), Positives = 104/210 (49%), Gaps = 25/210 (11%)

Query: 10  KVVVVTGGGRGIGAGIVRAFVNSG----ARVVICDKDESGGRALEQ----ELPGAVFILC 61
           K V+VTG   G G  + +   + G    A  ++ DK   G + L+      L      +C
Sbjct: 56  KAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVC 115

Query: 62  DVTQEDDVKTLVSETIRRFGR-LDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYT 120
              + + V  +V  +++   + +  +VNNAG     +  E TS + ++Q+ E+NL GT  
Sbjct: 116 SSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGE-VEFTSLETYKQVAEVNLWGTVR 174

Query: 121 LTKLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVN 180
           +TK  LP +R+++G V+NISS++G +      PY  TK  V A +  L  +  P GV+V+
Sbjct: 175 MTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVS 234

Query: 181 CISPGN------IWTP---------LWEEL 195
            + PGN      +++P         +WEEL
Sbjct: 235 VVEPGNFIAATSLYSPESIQAIAKKMWEEL 264


>gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
           sapiens]
          Length = 343

 Score = 81.6 bits (200), Expect = 6e-16
 Identities = 62/210 (29%), Positives = 104/210 (49%), Gaps = 25/210 (11%)

Query: 10  KVVVVTGGGRGIGAGIVRAFVNSG----ARVVICDKDESGGRALEQ----ELPGAVFILC 61
           K V+VTG   G G  + +   + G    A  ++ DK   G + L+      L      +C
Sbjct: 56  KAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVC 115

Query: 62  DVTQEDDVKTLVSETIRRFGR-LDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYT 120
              + + V  +V  +++   + +  +VNNAG     +  E TS + ++Q+ E+NL GT  
Sbjct: 116 SSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGE-VEFTSLETYKQVAEVNLWGTVR 174

Query: 121 LTKLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVN 180
           +TK  LP +R+++G V+NISS++G +      PY  TK  V A +  L  +  P GV+V+
Sbjct: 175 MTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVS 234

Query: 181 CISPGN------IWTP---------LWEEL 195
            + PGN      +++P         +WEEL
Sbjct: 235 VVEPGNFIAATSLYSPESIQAIAKKMWEEL 264


>gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
           sapiens]
          Length = 343

 Score = 81.6 bits (200), Expect = 6e-16
 Identities = 62/210 (29%), Positives = 104/210 (49%), Gaps = 25/210 (11%)

Query: 10  KVVVVTGGGRGIGAGIVRAFVNSG----ARVVICDKDESGGRALEQ----ELPGAVFILC 61
           K V+VTG   G G  + +   + G    A  ++ DK   G + L+      L      +C
Sbjct: 56  KAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVC 115

Query: 62  DVTQEDDVKTLVSETIRRFGR-LDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYT 120
              + + V  +V  +++   + +  +VNNAG     +  E TS + ++Q+ E+NL GT  
Sbjct: 116 SSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGE-VEFTSLETYKQVAEVNLWGTVR 174

Query: 121 LTKLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVN 180
           +TK  LP +R+++G V+NISS++G +      PY  TK  V A +  L  +  P GV+V+
Sbjct: 175 MTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVS 234

Query: 181 CISPGN------IWTP---------LWEEL 195
            + PGN      +++P         +WEEL
Sbjct: 235 VVEPGNFIAATSLYSPESIQAIAKKMWEEL 264


>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
           sapiens]
          Length = 325

 Score = 80.5 bits (197), Expect = 1e-15
 Identities = 56/192 (29%), Positives = 92/192 (47%), Gaps = 12/192 (6%)

Query: 11  VVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGA----------VFIL 60
           VVV+TG   G+G    + F  +GA++V+C ++      L +EL  +            + 
Sbjct: 54  VVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKPYLVT 113

Query: 61  CDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYT 120
            D+T    +    +E ++ FG +D +VNNAG        + T+    ++++E N  G   
Sbjct: 114 FDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMD-TTVDVDKRVMETNYFGPVA 172

Query: 121 LTKLALP-YLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRV 179
           LTK  LP  +++ QG+++ ISS+ G +       Y A+K A  A    L  +   Y + V
Sbjct: 173 LTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQYEIEV 232

Query: 180 NCISPGNIWTPL 191
             ISPG I T L
Sbjct: 233 TVISPGYIHTNL 244


>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
           sapiens]
          Length = 339

 Score = 76.3 bits (186), Expect = 3e-14
 Identities = 58/199 (29%), Positives = 97/199 (48%), Gaps = 15/199 (7%)

Query: 11  VVVVTGGGRGIGAGIVRAFVNSGARVVICDK-----DESGGRALEQ---ELPGAVFILCD 62
           VV VTG   GIG  +       G  +V+  +     +    R LE    +    + +  D
Sbjct: 52  VVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLD 111

Query: 63  VTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRP--EETSAQGFRQLLELNLLGTYT 120
           +T     +      ++ FGR+D +VNN G     QR    +TS   +R+L+ELN LGT +
Sbjct: 112 LTDTGSHEAATKAVLQEFGRIDILVNNGGMS---QRSLCMDTSLDVYRKLIELNYLGTVS 168

Query: 121 LTKLALPY-LRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPY-GVR 178
           LTK  LP+ + + QG ++ ++S++G I    ++ Y A+K A+      L  + + Y G+ 
Sbjct: 169 LTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGII 228

Query: 179 VNCISPGNIWTPLWEELAA 197
           V+ I PG + + + E   A
Sbjct: 229 VSNICPGPVQSNIVENSLA 247


>gi|150247226 retinol dehydrogenase 16 [Homo sapiens]
          Length = 317

 Score = 74.7 bits (182), Expect = 8e-14
 Identities = 58/180 (32%), Positives = 88/180 (48%), Gaps = 6/180 (3%)

Query: 10  KVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAV-FILCDVTQEDD 68
           K V +TG   G G  + R     G RV+     E G   L  +    +  +  DVT+ + 
Sbjct: 30  KYVFITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVTKTES 89

Query: 69  VKTL---VSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLA 125
           V      V E +R  G L  +VNNAG   P    E  + Q F  +L++NLLG   +T   
Sbjct: 90  VAAAAQWVKECVRDKG-LWGLVNNAGISLPTAPNELLTKQDFVTILDVNLLGVIDVTLSL 148

Query: 126 LPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPG 185
           LP +R+++G V+N+SS++G +       Y  +K  V A + +L  + S +GV+V  I PG
Sbjct: 149 LPLVRRARGRVVNVSSVMGRVSLFGG-GYCISKYGVEAFSDSLRRELSYFGVKVAMIEPG 207


>gi|126723191 dehydrogenase/reductase (SDR family) member 4 like 2
           [Homo sapiens]
          Length = 232

 Score = 69.3 bits (168), Expect = 3e-12
 Identities = 46/178 (25%), Positives = 83/178 (46%), Gaps = 5/178 (2%)

Query: 10  KVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPG----AVFILCDVTQ 65
           KV +VT    GIG  I R      A VV+  + +         L G        +C V +
Sbjct: 33  KVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGK 92

Query: 66  EDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLA 125
            +D + LV+  ++  G +D +V+NA  +P      + + + + + L++N+     +TK  
Sbjct: 93  AEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINVKAPALMTKAV 152

Query: 126 LPYLRKSQGNVINISSLVGAIGQAQAV-PYVATKGAVTAMTKALALDESPYGVRVNCI 182
           +P + K  G  + I S + A   +    PY  +K A+  +   LA++ +P  +RVNC+
Sbjct: 153 VPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNNTLAIELAPRNIRVNCL 210


>gi|22507405 short chain dehydrogenase/reductase family 9C, member 7
           [Homo sapiens]
          Length = 313

 Score = 68.6 bits (166), Expect = 6e-12
 Identities = 51/185 (27%), Positives = 90/185 (48%), Gaps = 4/185 (2%)

Query: 10  KVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAV-FILCDVTQEDD 68
           K V +TG   G G  + +  V+ G +V+     E G + L+++    +   L DVT+ + 
Sbjct: 26  KYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGSQKLQRDTSYRLQTTLLDVTKSES 85

Query: 69  VKTLVSETIRRFGR--LDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLAL 126
           +K        + G   L  +VNNAG   P    E  +   F +++ +NL+G   +T   L
Sbjct: 86  IKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKVINVNLVGLIEVTLHML 145

Query: 127 PYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGN 186
           P +++++G V+N+SS  G +       Y  +K  V A + ++  +   +GV+V  I PGN
Sbjct: 146 PMVKRARGRVVNMSSSGGRVAVIGG-GYCVSKFGVEAFSDSIRRELYYFGVKVCIIEPGN 204

Query: 187 IWTPL 191
             T +
Sbjct: 205 YRTAI 209


>gi|119392083 hydroxysteroid (11-beta) dehydrogenase 2 [Homo
           sapiens]
          Length = 405

 Score = 68.2 bits (165), Expect = 7e-12
 Identities = 49/183 (26%), Positives = 81/183 (44%), Gaps = 5/183 (2%)

Query: 8   AGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQEL---PGAVFILCDVT 64
           A + V++TG   G G    +   + G  V+    + +   A+E      P    +  D+T
Sbjct: 81  ATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLT 140

Query: 65  QEDDVKTLVSETIRRFGRLDC--VVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLT 122
           +  D+  ++  T           +VNNAGH+      E +    FR  +E+N  G   LT
Sbjct: 141 KPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELT 200

Query: 123 KLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCI 182
           K  LP LR S+G ++ + S  G +       Y  +K AV  +    + +  P+GV+V+ I
Sbjct: 201 KGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSII 260

Query: 183 SPG 185
            PG
Sbjct: 261 QPG 263


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.136    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,644,076
Number of Sequences: 37866
Number of extensions: 473118
Number of successful extensions: 1311
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 64
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 1137
Number of HSP's gapped (non-prelim): 94
length of query: 270
length of database: 18,247,518
effective HSP length: 101
effective length of query: 169
effective length of database: 14,423,052
effective search space: 2437495788
effective search space used: 2437495788
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.