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Search of human proteins with 59797060
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|59797060 arylsulfatase family, member I [Homo sapiens]
(569 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|59797060 arylsulfatase family, member I [Homo sapiens] 1201 0.0
gi|109389362 arylsulfatase J [Homo sapiens] 741 0.0
gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens] 545 e-155
gi|38569407 arylsulfatase B isoform 2 precursor [Homo sapiens] 459 e-129
gi|4503899 galactosamine (N-acetyl)-6-sulfate sulfatase precurso... 174 2e-43
gi|146229331 arylsulfatase A isoform a precursor [Homo sapiens] 150 3e-36
gi|146229329 arylsulfatase A isoform a precursor [Homo sapiens] 150 3e-36
gi|146229324 arylsulfatase A isoform a precursor [Homo sapiens] 150 3e-36
gi|6005990 arylsulfatase A isoform a precursor [Homo sapiens] 150 3e-36
gi|71852584 arylsulfatase D isoform a precursor [Homo sapiens] 120 3e-27
gi|45430057 Arylsulfatase G [Homo sapiens] 119 7e-27
gi|146229327 arylsulfatase A isoform b [Homo sapiens] 93 6e-19
gi|53831991 steryl-sulfatase precursor [Homo sapiens] 92 1e-18
gi|31742482 arylsulfatase F precursor [Homo sapiens] 91 3e-18
gi|157266309 arylsulfatase E precursor [Homo sapiens] 91 3e-18
gi|71852586 arylsulfatase D isoform b precursor [Homo sapiens] 88 2e-17
gi|58743319 arylsulfatase family, member H [Homo sapiens] 82 1e-15
gi|4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo sap... 74 3e-13
gi|4504061 glucosamine (N-acetyl)-6-sulfatase precursor [Homo sa... 65 2e-10
gi|189571643 sulfatase 1 [Homo sapiens] 61 2e-09
gi|189571641 sulfatase 1 [Homo sapiens] 61 2e-09
gi|189571638 sulfatase 1 [Homo sapiens] 61 2e-09
gi|189571636 sulfatase 1 [Homo sapiens] 61 2e-09
gi|240255483 sulfatase 2 isoform a precursor [Homo sapiens] 58 3e-08
gi|240255478 sulfatase 2 isoform b precursor [Homo sapiens] 58 3e-08
gi|29789100 sulfatase 2 isoform a precursor [Homo sapiens] 58 3e-08
gi|4557659 iduronate-2-sulfatase isoform a precursor [Homo sapiens] 55 2e-07
gi|5360208 iduronate-2-sulfatase isoform b precursor [Homo sapiens] 49 1e-05
gi|169217295 PREDICTED: similar to iduronate 2-sulfatase (Hunter... 41 0.003
gi|39930577 arylsulfatase K [Homo sapiens] 36 0.11
>gi|59797060 arylsulfatase family, member I [Homo sapiens]
Length = 569
Score = 1201 bits (3106), Expect = 0.0
Identities = 569/569 (100%), Positives = 569/569 (100%)
Query: 1 MHTLTGFSLVSLLSFGYLSWDWAKPSFVADGPGEAGEQPSAAPPQPPHIIFILTDDQGYH 60
MHTLTGFSLVSLLSFGYLSWDWAKPSFVADGPGEAGEQPSAAPPQPPHIIFILTDDQGYH
Sbjct: 1 MHTLTGFSLVSLLSFGYLSWDWAKPSFVADGPGEAGEQPSAAPPQPPHIIFILTDDQGYH 60
Query: 61 DVGYHGSDIETPTLDRLAAKGVKLENYYIQPICTPSRSQLLTGRYQIHTGLQHSIIRPQQ 120
DVGYHGSDIETPTLDRLAAKGVKLENYYIQPICTPSRSQLLTGRYQIHTGLQHSIIRPQQ
Sbjct: 61 DVGYHGSDIETPTLDRLAAKGVKLENYYIQPICTPSRSQLLTGRYQIHTGLQHSIIRPQQ 120
Query: 121 PNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGFYRKECLPTRRGFDTFLGSLTGNVDYYTY 180
PNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGFYRKECLPTRRGFDTFLGSLTGNVDYYTY
Sbjct: 121 PNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGFYRKECLPTRRGFDTFLGSLTGNVDYYTY 180
Query: 181 DNCDGPGVCGFDLHEGENVAWGLSGQYSTMLYAQRASHILASHSPQRPLFLYVAFQAVHT 240
DNCDGPGVCGFDLHEGENVAWGLSGQYSTMLYAQRASHILASHSPQRPLFLYVAFQAVHT
Sbjct: 181 DNCDGPGVCGFDLHEGENVAWGLSGQYSTMLYAQRASHILASHSPQRPLFLYVAFQAVHT 240
Query: 241 PLQSPREYLYRYRTMGNVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGG 300
PLQSPREYLYRYRTMGNVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGG
Sbjct: 241 PLQSPREYLYRYRTMGNVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGG 300
Query: 301 QTFSGGSNWPLRGRKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAGG 360
QTFSGGSNWPLRGRKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAGG
Sbjct: 301 QTFSGGSNWPLRGRKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAGG 360
Query: 361 TTSAADGLDGYDVWPAISEGRASPRTEILHNIDPLYNHAQHGSLEGGFGIWNTAVQAAIR 420
TTSAADGLDGYDVWPAISEGRASPRTEILHNIDPLYNHAQHGSLEGGFGIWNTAVQAAIR
Sbjct: 361 TTSAADGLDGYDVWPAISEGRASPRTEILHNIDPLYNHAQHGSLEGGFGIWNTAVQAAIR 420
Query: 421 VGEWKLLTGDPGYGDWIPPQTLATFPGSWWNLERMASVRQAVWLFNISADPYEREDLAGQ 480
VGEWKLLTGDPGYGDWIPPQTLATFPGSWWNLERMASVRQAVWLFNISADPYEREDLAGQ
Sbjct: 421 VGEWKLLTGDPGYGDWIPPQTLATFPGSWWNLERMASVRQAVWLFNISADPYEREDLAGQ 480
Query: 481 RPDVVRTLLARLAEYNRTAIPVRYPAENPRAHPDFNGGAWGPWASDEEEEEEEGRARSFS 540
RPDVVRTLLARLAEYNRTAIPVRYPAENPRAHPDFNGGAWGPWASDEEEEEEEGRARSFS
Sbjct: 481 RPDVVRTLLARLAEYNRTAIPVRYPAENPRAHPDFNGGAWGPWASDEEEEEEEGRARSFS 540
Query: 541 RGRRKKKCKICKLRSFFRKLNTRLMSQRI 569
RGRRKKKCKICKLRSFFRKLNTRLMSQRI
Sbjct: 541 RGRRKKKCKICKLRSFFRKLNTRLMSQRI 569
>gi|109389362 arylsulfatase J [Homo sapiens]
Length = 599
Score = 741 bits (1913), Expect = 0.0
Identities = 339/555 (61%), Positives = 431/555 (77%), Gaps = 7/555 (1%)
Query: 1 MHTLTGFSLVSLLSFGYLSWDWAKPSFVADGP--GEAGE--QPSAAPPQPPHIIFILTDD 56
M L GF ++ LL++GYLSW A +G +AGE +PS PH+IFIL DD
Sbjct: 27 MGALAGFWILCLLTYGYLSWGQALEE-EEEGALLAQAGEKLEPSTTSTSQPHLIFILADD 85
Query: 57 QGYHDVGYHGSDIETPTLDRLAAKGVKLENYYIQPICTPSRSQLLTGRYQIHTGLQHSII 116
QG+ DVGYHGS+I+TPTLD+LAA+GVKLENYY+QPICTPSRSQ +TG+YQIHTGLQHSII
Sbjct: 86 QGFRDVGYHGSEIKTPTLDKLAAEGVKLENYYVQPICTPSRSQFITGKYQIHTGLQHSII 145
Query: 117 RPQQPNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGFYRKECLPTRRGFDTFLGSLTGNVD 176
RP QPNCLPLD TLPQKL+E GYSTHMVGKWHLGFYRKEC+PTRRGFDTF GSL G+ D
Sbjct: 146 RPTQPNCLPLDNATLPQKLKEVGYSTHMVGKWHLGFYRKECMPTRRGFDTFFGSLLGSGD 205
Query: 177 YYTYDNCDGPGVCGFDLHEGENVAWGL-SGQYSTMLYAQRASHILASHSPQRPLFLYVAF 235
YYT+ CD PG+CG+DL+E +N AW +G YST +Y QR ILASH+P +P+FLY+A+
Sbjct: 206 YYTHYKCDSPGMCGYDLYENDNAAWDYDNGIYSTQMYTQRVQQILASHNPTKPIFLYIAY 265
Query: 236 QAVHTPLQSPREYLYRYRTMGNVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFS 295
QAVH+PLQ+P Y YR++ N+ RR+YAAM++C+DEA+ N+T ALK YGFYNNS+II+S
Sbjct: 266 QAVHSPLQAPGRYFEHYRSIININRRRYAAMLSCLDEAINNVTLALKTYGFYNNSIIIYS 325
Query: 296 SDNGGQTFSGGSNWPLRGRKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLV 355
SDNGGQ +GGSNWPLRG KGTYWEGG+R +GFVHSPLLK K + L+HITDWYPTL+
Sbjct: 326 SDNGGQPTAGGSNWPLRGSKGTYWEGGIRAVGFVHSPLLKNKGTVCKELVHITDWYPTLI 385
Query: 356 GLAGGTTSAADGLDGYDVWPAISEGRASPRTEILHNIDPLYNHAQHGSLEGGFGIWNTAV 415
LA G LDGYD+W ISEG SPR +ILHNIDP+Y A++GS G+GIWNTA+
Sbjct: 386 SLAEGQIDEDIQLDGYDIWETISEGLRSPRVDILHNIDPIYTKAKNGSWAAGYGIWNTAI 445
Query: 416 QAAIRVGEWKLLTGDPGYGDWIPPQTLATFPGSWWNLERMA-SVRQAVWLFNISADPYER 474
Q+AIRV WKLLTG+PGY DW+PPQ+ + + W+ ER+ S ++VWLFNI+ADPYER
Sbjct: 446 QSAIRVQHWKLLTGNPGYSDWVPPQSFSNLGPNRWHNERITLSTGKSVWLFNITADPYER 505
Query: 475 EDLAGQRPDVVRTLLARLAEYNRTAIPVRYPAENPRAHPDFNGGAWGPWASDEEEEEEEG 534
DL+ + P +V+ LL RL+++N+TA+PVRYP ++PR++P NGG WGPW +E ++++
Sbjct: 506 VDLSNRYPGIVKKLLRRLSQFNKTAVPVRYPPKDPRSNPRLNGGVWGPWYKEETKKKKPS 565
Query: 535 RARSFSRGRRKKKCK 549
+ ++ + ++ KK K
Sbjct: 566 KNQAEKKQKKSKKKK 580
>gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens]
Length = 533
Score = 545 bits (1405), Expect = e-155
Identities = 274/502 (54%), Positives = 344/502 (68%), Gaps = 27/502 (5%)
Query: 41 AAPPQPPHIIFILTDDQGYHDVGYHGSDIETPTLDRLAAKGVKLENYYIQPICTPSRSQL 100
A +PPH++F+L DD G++DVG+HGS I TP LD LAA GV L+NYY QP+CTPSRSQL
Sbjct: 39 AGASRPPHLVFLLADDLGWNDVGFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQL 98
Query: 101 LTGRYQIHTGLQHSIIRPQQPNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGFYRKECLPT 160
LTGRYQI TGLQH II P QP+C+PLD+ LPQ L+EAGY+THMVGKWHLG YRKECLPT
Sbjct: 99 LTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPT 158
Query: 161 RRGFDTFLGSLTGNVDYYTYDNC---DGPGV--CGFDLHEGENVAWGLSGQYSTMLYAQR 215
RRGFDT+ G L G+ DYY+++ C D V C D +GE VA G YST ++ +R
Sbjct: 159 RRGFDTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKR 218
Query: 216 ASHILASHSPQRPLFLYVAFQAVHTPLQSPREYLYRYRTMGNVARRKYAAMVTCMDEAVR 275
A ++ +H P++PLFLY+A Q+VH PLQ P EYL Y + + R YA MV+ MDEAV
Sbjct: 219 AIALITNHPPEKPLFLYLALQSVHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVG 278
Query: 276 NITWALKRYGFYNNSVIIFSSDNGGQTFSGGSNWPLRGRKGTYWEGGVRGLGFVHSPLLK 335
N+T ALK G +NN+V IFS+DNGGQT +GG+NWPLRGRK + WEGGVRG+GFV SPLLK
Sbjct: 279 NVTAALKSSGLWNNTVFIFSTDNGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLK 338
Query: 336 RKQRTSRALMHITDWYPTLVGLAGGTTSAADGLDGYDVWPAISEGRASPRTEILHNIDPL 395
+K +R L+HI+DW PTLV LA G T+ LDG+DVW ISEG SPR E+LHNIDP
Sbjct: 339 QKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPN 398
Query: 396 Y-----------NHAQHGSLEGGFGIWNTAVQAAIRVGEWKLLTGDPGYGDWIPPQTLAT 444
+ A+ S + +NT+V AAIR G WKLLTG PG G W PP
Sbjct: 399 FVDSSPCPRNSMAPAKDDSSLPEYSAFNTSVHAAIRHGNWKLLTGYPGCGYWFPPP---- 454
Query: 445 FPGSWWNLERMAS---VRQAVWLFNISADPYEREDLAGQRPDVVRTLLARLAEYNRTAIP 501
S +N+ + S + +WLF+I DP ER DL+ + P +V LL+RL Y++ ++P
Sbjct: 455 ---SQYNVSEIPSSDPPTKTLWLFDIDRDPEERHDLSREYPHIVTKLLSRLQFYHKHSVP 511
Query: 502 VRYPAENPRAHPDFNGGAWGPW 523
V +PA++PR P G WGPW
Sbjct: 512 VYFPAQDPRCDPKAT-GVWGPW 532
>gi|38569407 arylsulfatase B isoform 2 precursor [Homo sapiens]
Length = 413
Score = 459 bits (1180), Expect = e-129
Identities = 220/359 (61%), Positives = 268/359 (74%), Gaps = 5/359 (1%)
Query: 41 AAPPQPPHIIFILTDDQGYHDVGYHGSDIETPTLDRLAAKGVKLENYYIQPICTPSRSQL 100
A +PPH++F+L DD G++DVG+HGS I TP LD LAA GV L+NYY QP+CTPSRSQL
Sbjct: 39 AGASRPPHLVFLLADDLGWNDVGFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQL 98
Query: 101 LTGRYQIHTGLQHSIIRPQQPNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGFYRKECLPT 160
LTGRYQI TGLQH II P QP+C+PLD+ LPQ L+EAGY+THMVGKWHLG YRKECLPT
Sbjct: 99 LTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPT 158
Query: 161 RRGFDTFLGSLTGNVDYYTYDNC---DGPGV--CGFDLHEGENVAWGLSGQYSTMLYAQR 215
RRGFDT+ G L G+ DYY+++ C D V C D +GE VA G YST ++ +R
Sbjct: 159 RRGFDTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKR 218
Query: 216 ASHILASHSPQRPLFLYVAFQAVHTPLQSPREYLYRYRTMGNVARRKYAAMVTCMDEAVR 275
A ++ +H P++PLFLY+A Q+VH PLQ P EYL Y + + R YA MV+ MDEAV
Sbjct: 219 AIALITNHPPEKPLFLYLALQSVHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVG 278
Query: 276 NITWALKRYGFYNNSVIIFSSDNGGQTFSGGSNWPLRGRKGTYWEGGVRGLGFVHSPLLK 335
N+T ALK G +NN+V IFS+DNGGQT +GG+NWPLRGRK + WEGGVRG+GFV SPLLK
Sbjct: 279 NVTAALKSSGLWNNTVFIFSTDNGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLK 338
Query: 336 RKQRTSRALMHITDWYPTLVGLAGGTTSAADGLDGYDVWPAISEGRASPRTEILHNIDP 394
+K +R L+HI+DW PTLV LA G T+ LDG+DVW ISEG SPR E+LHNIDP
Sbjct: 339 QKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDP 397
>gi|4503899 galactosamine (N-acetyl)-6-sulfate sulfatase precursor
[Homo sapiens]
Length = 522
Score = 174 bits (441), Expect = 2e-43
Identities = 126/402 (31%), Positives = 190/402 (47%), Gaps = 44/402 (10%)
Query: 40 SAAPPQPPHIIFILTDDQGYHDVGYHGSDI-ETPTLDRLAAKGVKLENYY-IQPICTPSR 97
++ PQPP+I+ +L DD G+ D+G +G ETP LDR+AA+G+ N+Y P+C+PSR
Sbjct: 24 ASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSR 83
Query: 98 SQLLTGRYQIHTGLQ------HSIIRPQQ-PNCLPLDQVTLPQKLQEAGYSTHMVGKWHL 150
+ LLTGR I G + PQ+ +P + LP+ L++AGY + +VGKWHL
Sbjct: 84 AALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHL 143
Query: 151 GFYRKECLPTRRGFDTFLGSLTGNVDYYTYDNCDGPGVCGFDLHEGENVAWGLSGQY--- 207
G +R + P + GFD + GS N + YDN P + + W + G+Y
Sbjct: 144 G-HRPQFHPLKHGFDEWFGS--PNCHFGPYDNKARPNIPVYR-------DWEMVGRYYEE 193
Query: 208 -----------STMLYAQRASHILASHSPQRPLFLYVAFQAVHTPLQSPREYLYRYRTMG 256
T +Y Q A + + P FLY A A H P+ + + +L G
Sbjct: 194 FPINLKTGEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFL------G 247
Query: 257 NVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQTFS----GGSNWPLR 312
R +Y V +D+++ I L+ +N+ + F+SDNG S GGSN P
Sbjct: 248 TSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFL 307
Query: 313 GRKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAGGTTSAADGLDGYD 372
K T +EGG+R P + S L I D + T + LAG T + +DG +
Sbjct: 308 CGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLN 367
Query: 373 VWPAISEGRASPRTEILHNIDPLYNHAQHGSLEGGFGIWNTA 414
+ P + +GR R + D L A G + F W +
Sbjct: 368 LLPTLLQGRLMDRPIFYYRGDTLM-AATLGQHKAHFWTWTNS 408
>gi|146229331 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 150 bits (379), Expect = 3e-36
Identities = 141/482 (29%), Positives = 205/482 (42%), Gaps = 76/482 (15%)
Query: 42 APPQPPHIIFILTDDQGYHDVGYHGSDIET-PTLDRLAAKGVKLENYYIQ-PICTPSRSQ 99
A +PP+I+ I DD GY D+G +G T P LD+LAA G++ ++Y+ +CTPSR+
Sbjct: 16 AVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAA 75
Query: 100 LLTGRYQIHTGLQHSIIRPQQPNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGFYRKEC-L 158
LLTGR + G+ ++ P LPL++VT+ + L GY T M GKWHLG + L
Sbjct: 76 LLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFL 135
Query: 159 PTRRGFDTFLGSLTGNVDYYTYDN--------------CDG---PGVCGFDLHEGENV-- 199
P +GF FLG Y++D CDG G+ L +V
Sbjct: 136 PPHQGFHRFLGI------PYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEA 189
Query: 200 --AW--GLSGQYSTMLYAQRASHILASHSPQRPLFLYVAFQAVHTPLQSPREYLYRYRTM 255
W GL +Y + A + RP FLY A H P S + + R
Sbjct: 190 QPPWLPGLEARYMAFAHDLMAD----AQRQDRPFFLYYASHHTHYPQFSGQSFAER---- 241
Query: 256 GNVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQTF---SGGSNWPLR 312
R + + +D AV + A+ G +++IF++DNG +T GG + LR
Sbjct: 242 --SGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLR 299
Query: 313 GRKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAGGTTSAADGLDGYD 372
KGT +EGGVR P + L D PTL LAG LDG+D
Sbjct: 300 CGKGTTYEGGVREPALAFWP-GHIAPGVTHELASSLDLLPTLAALAGAPLPNVT-LDGFD 357
Query: 373 VWPAISEGRASPRTEILHNIDPLYNHAQHGSLEGGFGIWNTAVQAAIRVGEWK--LLTGD 430
+ P + SPR + P Y G A+R G++K T
Sbjct: 358 LSPLLLGTGKSPRQSLF--FYPSYPDEVRGVF-------------AVRTGKYKAHFFTQG 402
Query: 431 PGYGDWIPPQTLATFPGSWWNLERMASVRQAVWLFNISADPYEREDL----AGQRPDVVR 486
+ D T + + + L+++S DP E +L AG P+V++
Sbjct: 403 SAHSD--------TTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQ 454
Query: 487 TL 488
L
Sbjct: 455 AL 456
>gi|146229329 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 150 bits (379), Expect = 3e-36
Identities = 141/482 (29%), Positives = 205/482 (42%), Gaps = 76/482 (15%)
Query: 42 APPQPPHIIFILTDDQGYHDVGYHGSDIET-PTLDRLAAKGVKLENYYIQ-PICTPSRSQ 99
A +PP+I+ I DD GY D+G +G T P LD+LAA G++ ++Y+ +CTPSR+
Sbjct: 16 AVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAA 75
Query: 100 LLTGRYQIHTGLQHSIIRPQQPNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGFYRKEC-L 158
LLTGR + G+ ++ P LPL++VT+ + L GY T M GKWHLG + L
Sbjct: 76 LLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFL 135
Query: 159 PTRRGFDTFLGSLTGNVDYYTYDN--------------CDG---PGVCGFDLHEGENV-- 199
P +GF FLG Y++D CDG G+ L +V
Sbjct: 136 PPHQGFHRFLGI------PYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEA 189
Query: 200 --AW--GLSGQYSTMLYAQRASHILASHSPQRPLFLYVAFQAVHTPLQSPREYLYRYRTM 255
W GL +Y + A + RP FLY A H P S + + R
Sbjct: 190 QPPWLPGLEARYMAFAHDLMAD----AQRQDRPFFLYYASHHTHYPQFSGQSFAER---- 241
Query: 256 GNVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQTF---SGGSNWPLR 312
R + + +D AV + A+ G +++IF++DNG +T GG + LR
Sbjct: 242 --SGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLR 299
Query: 313 GRKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAGGTTSAADGLDGYD 372
KGT +EGGVR P + L D PTL LAG LDG+D
Sbjct: 300 CGKGTTYEGGVREPALAFWP-GHIAPGVTHELASSLDLLPTLAALAGAPLPNVT-LDGFD 357
Query: 373 VWPAISEGRASPRTEILHNIDPLYNHAQHGSLEGGFGIWNTAVQAAIRVGEWK--LLTGD 430
+ P + SPR + P Y G A+R G++K T
Sbjct: 358 LSPLLLGTGKSPRQSLF--FYPSYPDEVRGVF-------------AVRTGKYKAHFFTQG 402
Query: 431 PGYGDWIPPQTLATFPGSWWNLERMASVRQAVWLFNISADPYEREDL----AGQRPDVVR 486
+ D T + + + L+++S DP E +L AG P+V++
Sbjct: 403 SAHSD--------TTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQ 454
Query: 487 TL 488
L
Sbjct: 455 AL 456
>gi|146229324 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 150 bits (379), Expect = 3e-36
Identities = 141/482 (29%), Positives = 205/482 (42%), Gaps = 76/482 (15%)
Query: 42 APPQPPHIIFILTDDQGYHDVGYHGSDIET-PTLDRLAAKGVKLENYYIQ-PICTPSRSQ 99
A +PP+I+ I DD GY D+G +G T P LD+LAA G++ ++Y+ +CTPSR+
Sbjct: 16 AVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAA 75
Query: 100 LLTGRYQIHTGLQHSIIRPQQPNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGFYRKEC-L 158
LLTGR + G+ ++ P LPL++VT+ + L GY T M GKWHLG + L
Sbjct: 76 LLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFL 135
Query: 159 PTRRGFDTFLGSLTGNVDYYTYDN--------------CDG---PGVCGFDLHEGENV-- 199
P +GF FLG Y++D CDG G+ L +V
Sbjct: 136 PPHQGFHRFLGI------PYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEA 189
Query: 200 --AW--GLSGQYSTMLYAQRASHILASHSPQRPLFLYVAFQAVHTPLQSPREYLYRYRTM 255
W GL +Y + A + RP FLY A H P S + + R
Sbjct: 190 QPPWLPGLEARYMAFAHDLMAD----AQRQDRPFFLYYASHHTHYPQFSGQSFAER---- 241
Query: 256 GNVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQTF---SGGSNWPLR 312
R + + +D AV + A+ G +++IF++DNG +T GG + LR
Sbjct: 242 --SGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLR 299
Query: 313 GRKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAGGTTSAADGLDGYD 372
KGT +EGGVR P + L D PTL LAG LDG+D
Sbjct: 300 CGKGTTYEGGVREPALAFWP-GHIAPGVTHELASSLDLLPTLAALAGAPLPNVT-LDGFD 357
Query: 373 VWPAISEGRASPRTEILHNIDPLYNHAQHGSLEGGFGIWNTAVQAAIRVGEWK--LLTGD 430
+ P + SPR + P Y G A+R G++K T
Sbjct: 358 LSPLLLGTGKSPRQSLF--FYPSYPDEVRGVF-------------AVRTGKYKAHFFTQG 402
Query: 431 PGYGDWIPPQTLATFPGSWWNLERMASVRQAVWLFNISADPYEREDL----AGQRPDVVR 486
+ D T + + + L+++S DP E +L AG P+V++
Sbjct: 403 SAHSD--------TTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQ 454
Query: 487 TL 488
L
Sbjct: 455 AL 456
>gi|6005990 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 150 bits (379), Expect = 3e-36
Identities = 141/482 (29%), Positives = 205/482 (42%), Gaps = 76/482 (15%)
Query: 42 APPQPPHIIFILTDDQGYHDVGYHGSDIET-PTLDRLAAKGVKLENYYIQ-PICTPSRSQ 99
A +PP+I+ I DD GY D+G +G T P LD+LAA G++ ++Y+ +CTPSR+
Sbjct: 16 AVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAA 75
Query: 100 LLTGRYQIHTGLQHSIIRPQQPNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGFYRKEC-L 158
LLTGR + G+ ++ P LPL++VT+ + L GY T M GKWHLG + L
Sbjct: 76 LLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFL 135
Query: 159 PTRRGFDTFLGSLTGNVDYYTYDN--------------CDG---PGVCGFDLHEGENV-- 199
P +GF FLG Y++D CDG G+ L +V
Sbjct: 136 PPHQGFHRFLGI------PYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEA 189
Query: 200 --AW--GLSGQYSTMLYAQRASHILASHSPQRPLFLYVAFQAVHTPLQSPREYLYRYRTM 255
W GL +Y + A + RP FLY A H P S + + R
Sbjct: 190 QPPWLPGLEARYMAFAHDLMAD----AQRQDRPFFLYYASHHTHYPQFSGQSFAER---- 241
Query: 256 GNVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQTF---SGGSNWPLR 312
R + + +D AV + A+ G +++IF++DNG +T GG + LR
Sbjct: 242 --SGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLR 299
Query: 313 GRKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAGGTTSAADGLDGYD 372
KGT +EGGVR P + L D PTL LAG LDG+D
Sbjct: 300 CGKGTTYEGGVREPALAFWP-GHIAPGVTHELASSLDLLPTLAALAGAPLPNVT-LDGFD 357
Query: 373 VWPAISEGRASPRTEILHNIDPLYNHAQHGSLEGGFGIWNTAVQAAIRVGEWK--LLTGD 430
+ P + SPR + P Y G A+R G++K T
Sbjct: 358 LSPLLLGTGKSPRQSLF--FYPSYPDEVRGVF-------------AVRTGKYKAHFFTQG 402
Query: 431 PGYGDWIPPQTLATFPGSWWNLERMASVRQAVWLFNISADPYEREDL----AGQRPDVVR 486
+ D T + + + L+++S DP E +L AG P+V++
Sbjct: 403 SAHSD--------TTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQ 454
Query: 487 TL 488
L
Sbjct: 455 AL 456
>gi|71852584 arylsulfatase D isoform a precursor [Homo sapiens]
Length = 593
Score = 120 bits (302), Expect = 3e-27
Identities = 120/457 (26%), Positives = 188/457 (41%), Gaps = 93/457 (20%)
Query: 38 QPSAAPPQPPHIIFILTDDQGYHDVGYHGSD-IETPTLDRLAAKGVKLENYYIQ-PICTP 95
+P A P+I+ I+ DD G D+G +G++ + TP +D+LA +GV+L + P+CTP
Sbjct: 32 EPKTANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGVRLTQHLAAAPLCTP 91
Query: 96 SRSQLLTGRYQIHTGLQHSI-IRPQQPNC----LPLDQVTLPQKLQEAGYSTHMVGKWHL 150
SR+ LTGR+ +G+ S R Q N LP ++ T + LQ+ GY+T ++GKWH
Sbjct: 92 SRAAFLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETTFARILQQHGYATGLIGKWHQ 151
Query: 151 GFYRKECL--------PTRRGFDTFLG---SLTGNVD--------------YYTYDNCDG 185
G C P GFD F G +LT + D + Y
Sbjct: 152 GV---NCASRGDHCHHPLNHGFDYFYGMPFTLTNDCDPGRPPEVDAALRAQLWGYTQFLA 208
Query: 186 PGV--------CGFDLHEGENVAWGLSG--------QYSTMLYAQRASHILASHS--PQR 227
G+ CGF G++G YS+ + +R + IL + ++
Sbjct: 209 LGILTLAAGQTCGF-FSVSARAVTGMAGVGCLFFISWYSSFGFVRRWNCILMRNHDVTEQ 267
Query: 228 PL-------------------------FLYVAFQAVHTPLQSPREYLYRYRTMGNVARRK 262
P+ L+++ VH PL + +L G
Sbjct: 268 PMVLEKTASLMLKEAVSYIERHKHGPFLLFLSLLHVHIPLVTTSAFL------GKSQHGL 321
Query: 263 YAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQTFS-------GGSNWPLRGRK 315
Y V MD + + A++ G N++ F+SD+GG + GG N +G K
Sbjct: 322 YGDNVEEMDWLIGKVLNAIEDNGLKNSTFTYFTSDHGGHLEARDGHSQLGGWNGIYKGGK 381
Query: 316 GT-YWEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAGGTTSAADGLDGYDVW 374
G WEGG+R G H P + R + D +PT+V L GG +DG+ +
Sbjct: 382 GMGGWEGGIRVPGIFHWPGVLPAGRVIGEPTSLMDVFPTVVQLVGGEVPQDRVIDGHSLV 441
Query: 375 PAISEGRASPRTEILHNIDPLYNHAQHGSLEGGFGIW 411
P + A E L + + HA + +W
Sbjct: 442 PLLQGAEARSAHEFLFHYCGQHLHAARWHQKDSGSVW 478
>gi|45430057 Arylsulfatase G [Homo sapiens]
Length = 525
Score = 119 bits (298), Expect = 7e-27
Identities = 115/389 (29%), Positives = 172/389 (44%), Gaps = 60/389 (15%)
Query: 45 QPPHIIFILTDDQGYHDVGYHGSDI-ETPTLDRLAAKGVKLENYYIQP-ICTPSRSQLLT 102
Q P+ + IL DD G+ D+G + ++ +T LD++A++G++ +++ C+PSR+ LLT
Sbjct: 34 QKPNFVIILADDMGWGDLGANWAETKDTANLDKMASEGMRFVDFHAAASTCSPSRASLLT 93
Query: 103 GRYQIHTGLQHSIIRPQQPNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGFYRKECLPTRR 162
GR + G+ + LPL++ TL + LQ+AGY T ++GKWHLG + P R
Sbjct: 94 GRLGLRNGVTRNFAVTSVGG-LPLNETTLAEVLQQAGYVTGIIGKWHLG-HHGSYHPNFR 151
Query: 163 GFDTFLGSLTG------NVDYYTYDNC------DGPG-----VCGFD----LHEGEN-VA 200
GFD + G + Y + C DGP C D L+E N V
Sbjct: 152 GFDYYFGIPYSHDMGCTDTPGYNHPPCPACPQGDGPSRNLQRDCYTDVALPLYENLNIVE 211
Query: 201 WGLSGQYSTMLYAQRASHILASHSPQ-RPLFLYVAFQAVHTPL------QSPREYLYRYR 253
++ YA++A+ + S RP LYVA +H PL +PR
Sbjct: 212 QPVNLSSLAQKYAEKATQFIQRASTSGRPFLLYVALAHMHVPLPVTQLPAAPR------- 264
Query: 254 TMGNVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNG---GQTFSGGSNWP 310
R Y A + MD V I + + N+ + F+ DNG + GS P
Sbjct: 265 -----GRSLYGAGLWEMDSLVGQIKDKVD-HTVKENTFLWFTGDNGPWAQKCELAGSVGP 318
Query: 311 LRG----------RKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAGG 360
G K T WEGG R + P TS AL+ + D +PT+V LA
Sbjct: 319 FTGFWQTRQGGSPAKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAQA 378
Query: 361 TTSAADGLDGYDVWPAISEGRASPRTEIL 389
+ DG DV + GR+ P +L
Sbjct: 379 SLPQGRRFDGVDV-SEVLFGRSQPGHRVL 406
>gi|146229327 arylsulfatase A isoform b [Homo sapiens]
Length = 423
Score = 93.2 bits (230), Expect = 6e-19
Identities = 110/412 (26%), Positives = 160/412 (38%), Gaps = 74/412 (17%)
Query: 110 GLQHSIIRPQQPNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGFYRKEC-LPTRRGFDTFL 168
G+ ++ P LPL++VT+ + L GY T M GKWHLG + LP +GF FL
Sbjct: 2 GMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRFL 61
Query: 169 GSLTGNVDYYTYDN--------------CDG---PGVCGFDLHEGENV----AW--GLSG 205
G Y++D CDG G+ L +V W GL
Sbjct: 62 GI------PYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEA 115
Query: 206 QYSTMLYAQRASHILASHSPQRPLFLYVAFQAVHTPLQSPREYLYRYRTMGNVARRKYAA 265
+Y + A + RP FLY A H P S + + R R +
Sbjct: 116 RYMAFAHDLMAD----AQRQDRPFFLYYASHHTHYPQFSGQSFAER------SGRGPFGD 165
Query: 266 MVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQTF---SGGSNWPLRGRKGTYWEGG 322
+ +D AV + A+ G +++IF++DNG +T GG + LR KGT +EGG
Sbjct: 166 SLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGG 225
Query: 323 VRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAGGTTSAADGLDGYDVWPAISEGRA 382
VR P + L D PTL LAG LDG+D+ P +
Sbjct: 226 VREPALAFWP-GHIAPGVTHELASSLDLLPTLAALAGAPLPNVT-LDGFDLSPLLLGTGK 283
Query: 383 SPRTEILHNIDPLYNHAQHGSLEGGFGIWNTAVQAAIRVGEWK--LLTGDPGYGDWIPPQ 440
SPR + P Y G A+R G++K T + D
Sbjct: 284 SPRQSLF--FYPSYPDEVRGVF-------------AVRTGKYKAHFFTQGSAHSD----- 323
Query: 441 TLATFPGSWWNLERMASVRQAVWLFNISADPYEREDL----AGQRPDVVRTL 488
T + + + L+++S DP E +L AG P+V++ L
Sbjct: 324 ---TTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQAL 372
>gi|53831991 steryl-sulfatase precursor [Homo sapiens]
Length = 583
Score = 92.0 bits (227), Expect = 1e-18
Identities = 55/139 (39%), Positives = 79/139 (56%), Gaps = 13/139 (9%)
Query: 47 PHIIFILTDDQGYHDVGYHGSD-IETPTLDRLAAKGVKLENYYI-QPICTPSRSQLLTGR 104
P+II ++ DD G D G +G+ I TP +DRLA+ GVKL + P+CTPSR+ +TGR
Sbjct: 27 PNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGR 86
Query: 105 YQIHTGLQH-----SIIRPQQPNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGF--YRKEC 157
Y + +G+ + LP D++T + L++ GYST ++GKWHLG + K
Sbjct: 87 YPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTD 146
Query: 158 L---PTRRGFDTFLG-SLT 172
P GF+ F G SLT
Sbjct: 147 FCHHPLHHGFNYFYGISLT 165
Score = 60.1 bits (144), Expect = 5e-09
Identities = 51/195 (26%), Positives = 80/195 (41%), Gaps = 16/195 (8%)
Query: 226 QRPLFLYVAFQAVHTPLQSPREYLYRYRTMGNVARRKYAAMVTCMDEAVRNITWALKRYG 285
+ P L +++ VHT L S +++ G Y V MD +V I L
Sbjct: 277 ETPFLLVLSYLHVHTALFSSKDFA------GKSQHGVYGDAVEEMDWSVGQILNLLDELR 330
Query: 286 FYNNSVIIFSSDNGGQT--------FSGGSNWPLRGRKGTYWEGGVRGLGFVHSP-LLKR 336
N+++I F+SD G GGSN +G K WEGG+R G + P +++
Sbjct: 331 LANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQA 390
Query: 337 KQRTSRALMHITDWYPTLVGLAGGTTSAADGLDGYDVWPAISEGRASPRTEILHNIDPLY 396
Q+ ++ D +PT+ LAG +DG D+ P + E L + Y
Sbjct: 391 GQKIDEPTSNM-DIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAY 449
Query: 397 NHAQHGSLEGGFGIW 411
+A + IW
Sbjct: 450 LNAVRWHPQNSTSIW 464
>gi|31742482 arylsulfatase F precursor [Homo sapiens]
Length = 590
Score = 90.9 bits (224), Expect = 3e-18
Identities = 55/135 (40%), Positives = 78/135 (57%), Gaps = 12/135 (8%)
Query: 47 PHIIFILTDDQGYHDVGYHGSD-IETPTLDRLAAKGVKLENYY-IQPICTPSRSQLLTGR 104
P+I+ I+ DD G D+G +G+D + TP +DRLA +GV+L + +C+PSRS LTGR
Sbjct: 30 PNIVLIMVDDLGIGDLGCYGNDTMRTPHIDRLAREGVRLTQHISAASLCSPSRSAFLTGR 89
Query: 105 YQIHTGLQHS-----IIRPQQPNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGF----YRK 155
Y I +G+ S I P LPL++ TL L++ GYST ++GKWH G
Sbjct: 90 YPIRSGMVSSGNRRVIQNLAVPAGLPLNETTLAALLKKQGYSTGLIGKWHQGLNCDSRSD 149
Query: 156 EC-LPTRRGFDTFLG 169
+C P GFD + G
Sbjct: 150 QCHHPYNYGFDYYYG 164
Score = 70.9 bits (172), Expect = 3e-12
Identities = 78/307 (25%), Positives = 118/307 (38%), Gaps = 35/307 (11%)
Query: 211 LYAQRASHILASHSPQRPLFLYVAFQAVHTPLQSPREYLYRYRTMGNVARRKYAAMVTCM 270
+ + A L HS + L L+ +F VHTPL + ++ G Y V M
Sbjct: 266 IMVKEAISFLERHSKETFL-LFFSFLHVHTPLPTTDDFT------GTSKHGLYGDNVEEM 318
Query: 271 DEAVRNITWALKRYGFYNNSVIIFSSDNGGQTFS-------GGSNWPLRGRKGTY-WEGG 322
D V I A+ +G NN+++ F+SD+GG + GG N +G KG WEGG
Sbjct: 319 DSMVGKILDAIDDFGLRNNTLVYFTSDHGGHLEARRGHAQLGGWNGIYKGGKGMGGWEGG 378
Query: 323 VRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAGGTTSAADGLDGYDVWPAISEGRA 382
+R G V P R + + D PT+ ++GG+ +DG D+ P +
Sbjct: 379 IRVPGIVRWPGKVPAGRLIKEPTSLMDILPTVASVSGGSLPQDRVIDGRDLMPLLQGNVR 438
Query: 383 SPRTEILHNIDPLYNHAQHGSLEGGFGIWNTAVQAAIRVGEWKLLTGDPGYGDWIPPQTL 442
E L + Y HA + G WK P + PP +
Sbjct: 439 HSEHEFLFHYCGSYLHAVRWIPKDDSG------------SVWKAHYVTPVFQ---PPASG 483
Query: 443 ATFPGSWWN-LERMASVRQAVWLFNISADPYEREDLAGQRPD----VVRTLLARLAEYNR 497
+ S + LF++S DP E L V++ + L E+
Sbjct: 484 GCYVTSLCRCFGEQVTYHNPPLLFDLSRDPSESTPLTPATEPLHDFVIKKVANALKEHQE 543
Query: 498 TAIPVRY 504
T +PV Y
Sbjct: 544 TIVPVTY 550
>gi|157266309 arylsulfatase E precursor [Homo sapiens]
Length = 589
Score = 90.9 bits (224), Expect = 3e-18
Identities = 53/135 (39%), Positives = 77/135 (57%), Gaps = 12/135 (8%)
Query: 47 PHIIFILTDDQGYHDVGYHGSD-IETPTLDRLAAKGVKLENYY-IQPICTPSRSQLLTGR 104
P+I+ ++ DD G D+G +G++ + TP +DRLA GVKL + +CTPSR+ LTGR
Sbjct: 38 PNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGR 97
Query: 105 YQIHTGLQHSI-IRPQQ----PNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGFYRKECL- 158
Y + +G+ SI R Q LP ++ T + L+E GY+T ++GKWHLG +
Sbjct: 98 YPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKILKEKGYATGLIGKWHLGLNCESASD 157
Query: 159 ----PTRRGFDTFLG 169
P GFD F G
Sbjct: 158 HCHHPLHHGFDHFYG 172
Score = 67.8 bits (164), Expect = 3e-11
Identities = 87/336 (25%), Positives = 127/336 (37%), Gaps = 53/336 (15%)
Query: 206 QYSTMLYAQRASHILASHSPQRPLFLYVAFQAVHTPLQSPREYLYRYRTMGNVARRKYAA 265
Q +T L Q + L + P L+V+F VH PL + +L G Y
Sbjct: 269 QRTTPLILQEVASFL-KRNKHGPFLLFVSFLHVHIPLITMENFL------GKSLHGLYGD 321
Query: 266 MVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQ-------TFSGGSNWPLRGRKGTY 318
V MD V I L G N+++I F+SD+GG T GG N +G KG
Sbjct: 322 NVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNGIYKGGKGMG 381
Query: 319 -WEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAGGTTSAADGLDGYDVWPAI 377
WEGG+R G P + R + D +PT+V LAGG +DG D+ P +
Sbjct: 382 GWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLLPLL 441
Query: 378 SEGRASPRTEILHNIDPLYNHAQHGSLEGGFGIWNTAVQAAIRVGEWKLLTGDPGYGDWI 437
E L + + HA W+ + + WK+ ++
Sbjct: 442 LGTAQHSDHEFLMHYCERFLHAAR---------WHQRDRGTM----WKV--------HFV 480
Query: 438 PPQTLATFPGSWWNLERMASVRQAV------WLFNISADPYEREDLAGQRPDVVRTLLAR 491
P G+ + + + V LF++S DP E L V ++ R
Sbjct: 481 TPVFQPEGAGACYGRKVCPCFGEKVVHHDPPLLFDLSRDPSETHILTPASEPVFYQVMER 540
Query: 492 LA----EYNRTAIPVRYPAENPRAHPDFNGGAWGPW 523
+ E+ RT PV P + R G W PW
Sbjct: 541 VQQAVWEHQRTLSPV--PLQLDRL-----GNIWRPW 569
>gi|71852586 arylsulfatase D isoform b precursor [Homo sapiens]
Length = 382
Score = 88.2 bits (217), Expect = 2e-17
Identities = 57/157 (36%), Positives = 85/157 (54%), Gaps = 21/157 (13%)
Query: 38 QPSAAPPQPPHIIFILTDDQGYHDVGYHGSD-IETPTLDRLAAKGVKLENYYIQ-PICTP 95
+P A P+I+ I+ DD G D+G +G++ + TP +D+LA +GV+L + P+CTP
Sbjct: 32 EPKTANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGVRLTQHLAAAPLCTP 91
Query: 96 SRSQLLTGRYQIHTGLQHSI-IRPQQPNC----LPLDQVTLPQKLQEAGYSTHMVGKWHL 150
SR+ LTGR+ +G+ S R Q N LP ++ T + LQ+ GY+T ++GKWH
Sbjct: 92 SRAAFLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETTFARILQQHGYATGLIGKWHQ 151
Query: 151 GFYRKECL--------PTRRGFDTFLG---SLTGNVD 176
G C P GFD F G +LT + D
Sbjct: 152 GV---NCASRGDHCHHPLNHGFDYFYGMPFTLTNDCD 185
>gi|58743319 arylsulfatase family, member H [Homo sapiens]
Length = 562
Score = 82.4 bits (202), Expect = 1e-15
Identities = 90/314 (28%), Positives = 128/314 (40%), Gaps = 49/314 (15%)
Query: 226 QRPLFLYVAFQAVHTPLQSPREYLYRYRTMGNVARRKYAAMVTCMDEAVRNITWALKRYG 285
+ P L+ +F VHTPL S ++++ G +Y V MD V I AL +
Sbjct: 258 REPFLLFFSFLHVHTPLISKKKFV------GRSKYGRYGDNVEEMDWMVGKILDALDQER 311
Query: 286 FYNNSVIIFSSDNGGQTFS-------GGSNWPLRGRKGTY-WEGGVRGLGFVHSPLLKRK 337
N++++ F+SDNGG GG N +G KG WEGG+R G P +
Sbjct: 312 LANHTLVYFTSDNGGHLEPLDGAVQLGGWNGIYKGGKGMGGWEGGIRVPGIFRWPSVLEA 371
Query: 338 QRTSRALMHITDWYPTLVGLAGGTTSAADGLDGYDVWPAISEGRASPRT-EILHNIDPLY 396
R + D YPTL + GG S +DG ++ P + EGRAS E L + +Y
Sbjct: 372 GRVINEPTSLMDIYPTLSYIGGGILSQDRVIDGQNLMPLL-EGRASHSDHEFLFHYCGVY 430
Query: 397 NHAQHGSLEGGFGIWNTAVQAAIRVGEWKLLTGDPGYGDWIPPQTLATFPGSWWNLERMA 456
H W+ A + WK P + P T A + +
Sbjct: 431 LHTVR---------WHQKDCATV----WKAHYVTPKF---YPEGTGACYGSGICSCSGDV 474
Query: 457 SVRQAVWLFNISADPYEREDLAGQRPD-------VVRTLLARLAEYNRTAIPVRYPAENP 509
+ LF+IS DP E L PD V++ + A + E+ RT PV P
Sbjct: 475 TYHDPPLLFDISRDPSEALPL---NPDNEPLFDSVIKKMEAAIREHRRTLTPV------P 525
Query: 510 RAHPDFNGGAWGPW 523
+ FN W PW
Sbjct: 526 QQFSVFN-TIWKPW 538
Score = 81.6 bits (200), Expect = 2e-15
Identities = 49/136 (36%), Positives = 72/136 (52%), Gaps = 13/136 (9%)
Query: 47 PHIIFILTDDQGYHDVGYHGSD-IETPTLDRLAAKGVKLENYYIQP-ICTPSRSQLLTGR 104
P+I+ ++ DD G D+ +G++ + TP +DRLA++GV+L + +CTPSR+ LTGR
Sbjct: 7 PNIVLLMADDLGVGDLCCYGNNSVSTPNIDRLASEGVRLTQHLAAASMCTPSRAAFLTGR 66
Query: 105 YQIHTG------LQHSIIRPQQPNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGF----YR 154
Y I +G L + LP ++ T + LQ GY T ++GKWHLG
Sbjct: 67 YPIRSGMVSAYNLNRAFTWLGGSGGLPTNETTFAKLLQHRGYRTGLIGKWHLGLSCASRN 126
Query: 155 KECL-PTRRGFDTFLG 169
C P GF F G
Sbjct: 127 DHCYHPLNHGFHYFYG 142
>gi|4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo
sapiens]
Length = 502
Score = 74.3 bits (181), Expect = 3e-13
Identities = 92/347 (26%), Positives = 131/347 (37%), Gaps = 80/347 (23%)
Query: 45 QPPHIIFILTDDQGYHDVGYHGSDIETPTLDRLAAKGVKLENYYIQ-PICTPSRSQLLTG 103
+P + + +L DD G+ Y+ S I TP LD LA + + N + C+PSR+ LLTG
Sbjct: 21 RPRNALLLLADDGGFESGAYNNSAIATPHLDALARRSLLFRNAFTSVSSCSPSRASLLTG 80
Query: 104 RYQIHTGLQHSIIRPQQPNCLPLDQV-TLPQKLQEAGYSTHMVGKWHLGFYRKECLPTRR 162
Q G+ + + D+V +LP L +AG T ++GK H+G T
Sbjct: 81 LPQHQNGMYG--LHQDVHHFNSFDKVRSLPLLLSQAGVRTGIIGKKHVG------PETVY 132
Query: 163 GFDTFLGSLTGNVDYYTYDNCDGPGVCGFDLHEGENVAWGLSGQYSTMLYAQRASHILAS 222
FD YT +N G L G N+ L ++
Sbjct: 133 PFDF----------AYTEEN-------GSVLQVGRNIT-------RIKLLVRK----FLQ 164
Query: 223 HSPQRPLFLYVAFQAVHTPLQSPREYLYRYRTMGN------------------------- 257
RP FLYVAF H S +Y GN
Sbjct: 165 TQDDRPFFLYVAFHDPHRCGHSQPQYGTFCEKFGNGESGMGRIPDWTPQAYDPLDVLVPY 224
Query: 258 ------VARRKYAAMVTC---MDEAVRNITWALKRYGFYNNSVIIFSSDNGGQTFSGGSN 308
AR AA T MD+ V + L+ G N++++IF+SDNG SG +N
Sbjct: 225 FVPNTPAARADLAAQYTTVGRMDQGVGLVLQELRDAGVLNDTLVIFTSDNGIPFPSGRTN 284
Query: 309 WPLRGRKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLV 355
YW G L KR + S A + + D PT++
Sbjct: 285 --------LYWPGTAEPLLVSSPEHPKRWGQVSEAYVSLLDLTPTIL 323
>gi|4504061 glucosamine (N-acetyl)-6-sulfatase precursor [Homo
sapiens]
Length = 552
Score = 65.1 bits (157), Expect = 2e-10
Identities = 90/389 (23%), Positives = 153/389 (39%), Gaps = 81/389 (20%)
Query: 41 AAPPQPPHIIFILTDDQGYHDVGYHGSDIETPTLDRLAAKGVKLENYYI-QPICTPSRSQ 99
AA + P+++ +LTDDQ D G T + G+ + Y+ +C PSR+
Sbjct: 41 AAGTRRPNVVLLLTDDQ---DEVLGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRAS 97
Query: 100 LLTGRYQIHTGLQHSIIRPQQPNCLPLDQVTLPQKLQE-----------AGYSTHMVGKW 148
+LTG+Y + H + + NC QK+QE GY T GK
Sbjct: 98 ILTGKYPHN---HHVVNNTLEGNCSSKSW----QKIQEPNTFPAILRSMCGYQTFFAGK- 149
Query: 149 HLGFYRKECLPTRRGFD------TFLGSLTGNVDYYTYDNCDGPGVCGFDLHEGENVAWG 202
+ + P G + ++ +L N YY Y + G GEN
Sbjct: 150 ---YLNEYGAPDAGGLEHVPLGWSYWYALEKNSKYYNYTL----SINGKARKHGENY--- 199
Query: 203 LSGQYSTMLYAQRASHILASHSPQRPLFLYVAFQAVHTPLQSPREYLYRYRT-------- 254
S Y T + A + L S P F+ +A A H+P + +Y ++
Sbjct: 200 -SVDYLTDVLANVSLDFLDYKSNFEPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPRNKN 258
Query: 255 --------------------------MGNVARRKYAAMVTCMDEAVRNITWALKRYGFYN 288
+ N R+++ +++ +D+ V + L+ G N
Sbjct: 259 FNIHGTNKHWLIRQAKTPMTNSSIQFLDNAFRKRWQTLLS-VDDLVEKLVKRLEFTGELN 317
Query: 289 NSVIIFSSDNGGQTFSGGSNWPLRGRKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHIT 348
N+ I ++SDNG T G + P+ R+ +E ++ V P +K Q TS+ L+
Sbjct: 318 NTYIFYTSDNGYHT--GQFSLPIDKRQ--LYEFDIKVPLLVRGPGIKPNQ-TSKMLVANI 372
Query: 349 DWYPTLVGLAGGTTSAADGLDGYDVWPAI 377
D PT++ +AG + +DG + P +
Sbjct: 373 DLGPTILDIAGYDLNKTQ-MDGMSLLPIL 400
>gi|189571643 sulfatase 1 [Homo sapiens]
Length = 871
Score = 61.2 bits (147), Expect = 2e-09
Identities = 87/351 (24%), Positives = 145/351 (41%), Gaps = 58/351 (16%)
Query: 47 PHIIFILTDDQGYHDVGYHGSDIETPTLDRLAAKGVKLENYYIQ-PICTPSRSQLLTGRY 105
P+II +LTDDQ DV + T + G N ++ P+C PSRS +LTG+Y
Sbjct: 43 PNIILVLTDDQ---DVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKY 99
Query: 106 QIHTGLQHSIIRPQQPNCLPLDQV-----TLPQKLQEAGYSTHMVGKWHLGFYRKECLPT 160
+H H++ + P Q T L GY T GK +L Y +P
Sbjct: 100 -VH---NHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGK-YLNEYNGSYIPP 154
Query: 161 RRGFDTFLGSLTGNVDYYTYDNCDGPGV---CGF--------DLHEGENVAWGLSGQYST 209
G+ +LG L N +Y Y C G+ GF DL E++ + + S
Sbjct: 155 --GWREWLG-LIKNSRFYNYTVCRN-GIKEKHGFDYAKDYFTDLITNESINY---FKMSK 207
Query: 210 MLYAQRASHILASH---------SPQ------------RPLFLYVAFQAVHTPLQSPREY 248
+Y R ++ SH +PQ P + Y H +Q
Sbjct: 208 RMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYNYAPNMDKHWIMQYTGPM 267
Query: 249 LYRYRTMGNVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQTFSGGSN 308
L + N+ +RK + +D++V + L G N+ II+++D+G + G
Sbjct: 268 LPIHMEFTNILQRKRLQTLMSVDDSVERLYNMLVETGELENTYIIYTADHG---YHIGQF 324
Query: 309 WPLRGRKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAG 359
++G+ Y + +R F+ P ++ + +++I D PT++ +AG
Sbjct: 325 GLVKGKSMPY-DFDIRVPFFIRGPSVEPGSIVPQIVLNI-DLAPTILDIAG 373
>gi|189571641 sulfatase 1 [Homo sapiens]
Length = 871
Score = 61.2 bits (147), Expect = 2e-09
Identities = 87/351 (24%), Positives = 145/351 (41%), Gaps = 58/351 (16%)
Query: 47 PHIIFILTDDQGYHDVGYHGSDIETPTLDRLAAKGVKLENYYIQ-PICTPSRSQLLTGRY 105
P+II +LTDDQ DV + T + G N ++ P+C PSRS +LTG+Y
Sbjct: 43 PNIILVLTDDQ---DVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKY 99
Query: 106 QIHTGLQHSIIRPQQPNCLPLDQV-----TLPQKLQEAGYSTHMVGKWHLGFYRKECLPT 160
+H H++ + P Q T L GY T GK +L Y +P
Sbjct: 100 -VH---NHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGK-YLNEYNGSYIPP 154
Query: 161 RRGFDTFLGSLTGNVDYYTYDNCDGPGV---CGF--------DLHEGENVAWGLSGQYST 209
G+ +LG L N +Y Y C G+ GF DL E++ + + S
Sbjct: 155 --GWREWLG-LIKNSRFYNYTVCRN-GIKEKHGFDYAKDYFTDLITNESINY---FKMSK 207
Query: 210 MLYAQRASHILASH---------SPQ------------RPLFLYVAFQAVHTPLQSPREY 248
+Y R ++ SH +PQ P + Y H +Q
Sbjct: 208 RMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYNYAPNMDKHWIMQYTGPM 267
Query: 249 LYRYRTMGNVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQTFSGGSN 308
L + N+ +RK + +D++V + L G N+ II+++D+G + G
Sbjct: 268 LPIHMEFTNILQRKRLQTLMSVDDSVERLYNMLVETGELENTYIIYTADHG---YHIGQF 324
Query: 309 WPLRGRKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAG 359
++G+ Y + +R F+ P ++ + +++I D PT++ +AG
Sbjct: 325 GLVKGKSMPY-DFDIRVPFFIRGPSVEPGSIVPQIVLNI-DLAPTILDIAG 373
>gi|189571638 sulfatase 1 [Homo sapiens]
Length = 871
Score = 61.2 bits (147), Expect = 2e-09
Identities = 87/351 (24%), Positives = 145/351 (41%), Gaps = 58/351 (16%)
Query: 47 PHIIFILTDDQGYHDVGYHGSDIETPTLDRLAAKGVKLENYYIQ-PICTPSRSQLLTGRY 105
P+II +LTDDQ DV + T + G N ++ P+C PSRS +LTG+Y
Sbjct: 43 PNIILVLTDDQ---DVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKY 99
Query: 106 QIHTGLQHSIIRPQQPNCLPLDQV-----TLPQKLQEAGYSTHMVGKWHLGFYRKECLPT 160
+H H++ + P Q T L GY T GK +L Y +P
Sbjct: 100 -VH---NHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGK-YLNEYNGSYIPP 154
Query: 161 RRGFDTFLGSLTGNVDYYTYDNCDGPGV---CGF--------DLHEGENVAWGLSGQYST 209
G+ +LG L N +Y Y C G+ GF DL E++ + + S
Sbjct: 155 --GWREWLG-LIKNSRFYNYTVCRN-GIKEKHGFDYAKDYFTDLITNESINY---FKMSK 207
Query: 210 MLYAQRASHILASH---------SPQ------------RPLFLYVAFQAVHTPLQSPREY 248
+Y R ++ SH +PQ P + Y H +Q
Sbjct: 208 RMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYNYAPNMDKHWIMQYTGPM 267
Query: 249 LYRYRTMGNVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQTFSGGSN 308
L + N+ +RK + +D++V + L G N+ II+++D+G + G
Sbjct: 268 LPIHMEFTNILQRKRLQTLMSVDDSVERLYNMLVETGELENTYIIYTADHG---YHIGQF 324
Query: 309 WPLRGRKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAG 359
++G+ Y + +R F+ P ++ + +++I D PT++ +AG
Sbjct: 325 GLVKGKSMPY-DFDIRVPFFIRGPSVEPGSIVPQIVLNI-DLAPTILDIAG 373
>gi|189571636 sulfatase 1 [Homo sapiens]
Length = 871
Score = 61.2 bits (147), Expect = 2e-09
Identities = 87/351 (24%), Positives = 145/351 (41%), Gaps = 58/351 (16%)
Query: 47 PHIIFILTDDQGYHDVGYHGSDIETPTLDRLAAKGVKLENYYIQ-PICTPSRSQLLTGRY 105
P+II +LTDDQ DV + T + G N ++ P+C PSRS +LTG+Y
Sbjct: 43 PNIILVLTDDQ---DVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKY 99
Query: 106 QIHTGLQHSIIRPQQPNCLPLDQV-----TLPQKLQEAGYSTHMVGKWHLGFYRKECLPT 160
+H H++ + P Q T L GY T GK +L Y +P
Sbjct: 100 -VH---NHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGK-YLNEYNGSYIPP 154
Query: 161 RRGFDTFLGSLTGNVDYYTYDNCDGPGV---CGF--------DLHEGENVAWGLSGQYST 209
G+ +LG L N +Y Y C G+ GF DL E++ + + S
Sbjct: 155 --GWREWLG-LIKNSRFYNYTVCRN-GIKEKHGFDYAKDYFTDLITNESINY---FKMSK 207
Query: 210 MLYAQRASHILASH---------SPQ------------RPLFLYVAFQAVHTPLQSPREY 248
+Y R ++ SH +PQ P + Y H +Q
Sbjct: 208 RMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYNYAPNMDKHWIMQYTGPM 267
Query: 249 LYRYRTMGNVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQTFSGGSN 308
L + N+ +RK + +D++V + L G N+ II+++D+G + G
Sbjct: 268 LPIHMEFTNILQRKRLQTLMSVDDSVERLYNMLVETGELENTYIIYTADHG---YHIGQF 324
Query: 309 WPLRGRKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAG 359
++G+ Y + +R F+ P ++ + +++I D PT++ +AG
Sbjct: 325 GLVKGKSMPY-DFDIRVPFFIRGPSVEPGSIVPQIVLNI-DLAPTILDIAG 373
>gi|240255483 sulfatase 2 isoform a precursor [Homo sapiens]
Length = 870
Score = 57.8 bits (138), Expect = 3e-08
Identities = 84/355 (23%), Positives = 139/355 (39%), Gaps = 66/355 (18%)
Query: 47 PHIIFILTDDQGYHDVGYHGSDIETPTLDRLAAKGVKLENYYIQ-PICTPSRSQLLTGRY 105
P+II +LTDDQ DV + T + G N ++ P+C PSRS +LTG+Y
Sbjct: 44 PNIILVLTDDQ---DVELGSMQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTGKY 100
Query: 106 QIHTGLQHSIIRPQQPNCLPLDQV-----TLPQKLQEAGYSTHMVGKWHLGFYRKECLPT 160
+H H+ + P Q T L GY T GK +L Y +P
Sbjct: 101 -VH---NHNTYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGK-YLNEYNGSYVPP 155
Query: 161 RRGFDTFLGSLTGNVDYYTYDNCDGPGVCGFDLHEGENVAWGLSGQYSTMLYAQRASHIL 220
G+ ++G L N +Y Y C G G + S Y T L +
Sbjct: 156 --GWKEWVG-LLKNSRFYNYTLCRN----GVKEKHGSD----YSKDYLTDLITNDSVSFF 204
Query: 221 ASHS---PQRPLFLYVAFQAVHTPLQSPREY-------------------------LYRY 252
+ P RP+ + ++ A H P S +Y + RY
Sbjct: 205 RTSKKMYPHRPVLMVISHAAPHGPEDSAPQYSRLFPNASQHITPSYNYAPNPDKHWIMRY 264
Query: 253 --------RTMGNVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQTFS 304
N+ +RK + +D+++ I L G +N+ I++++D+G +
Sbjct: 265 TGPMKPIHMEFTNMLQRKRLQTLMSVDDSMETIYNMLVETGELDNTYIVYTADHG---YH 321
Query: 305 GGSNWPLRGRKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAG 359
G ++G+ Y E +R +V P ++ +++I D PT++ +AG
Sbjct: 322 IGQFGLVKGKSMPY-EFDIRVPFYVRGPNVEAGCLNPHIVLNI-DLAPTILDIAG 374
>gi|240255478 sulfatase 2 isoform b precursor [Homo sapiens]
Length = 867
Score = 57.8 bits (138), Expect = 3e-08
Identities = 84/355 (23%), Positives = 139/355 (39%), Gaps = 66/355 (18%)
Query: 47 PHIIFILTDDQGYHDVGYHGSDIETPTLDRLAAKGVKLENYYIQ-PICTPSRSQLLTGRY 105
P+II +LTDDQ DV + T + G N ++ P+C PSRS +LTG+Y
Sbjct: 44 PNIILVLTDDQ---DVELGSMQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTGKY 100
Query: 106 QIHTGLQHSIIRPQQPNCLPLDQV-----TLPQKLQEAGYSTHMVGKWHLGFYRKECLPT 160
+H H+ + P Q T L GY T GK +L Y +P
Sbjct: 101 -VH---NHNTYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGK-YLNEYNGSYVPP 155
Query: 161 RRGFDTFLGSLTGNVDYYTYDNCDGPGVCGFDLHEGENVAWGLSGQYSTMLYAQRASHIL 220
G+ ++G L N +Y Y C G G + S Y T L +
Sbjct: 156 --GWKEWVG-LLKNSRFYNYTLCRN----GVKEKHGSD----YSKDYLTDLITNDSVSFF 204
Query: 221 ASHS---PQRPLFLYVAFQAVHTPLQSPREY-------------------------LYRY 252
+ P RP+ + ++ A H P S +Y + RY
Sbjct: 205 RTSKKMYPHRPVLMVISHAAPHGPEDSAPQYSRLFPNASQHITPSYNYAPNPDKHWIMRY 264
Query: 253 --------RTMGNVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQTFS 304
N+ +RK + +D+++ I L G +N+ I++++D+G +
Sbjct: 265 TGPMKPIHMEFTNMLQRKRLQTLMSVDDSMETIYNMLVETGELDNTYIVYTADHG---YH 321
Query: 305 GGSNWPLRGRKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAG 359
G ++G+ Y E +R +V P ++ +++I D PT++ +AG
Sbjct: 322 IGQFGLVKGKSMPY-EFDIRVPFYVRGPNVEAGCLNPHIVLNI-DLAPTILDIAG 374
>gi|29789100 sulfatase 2 isoform a precursor [Homo sapiens]
Length = 870
Score = 57.8 bits (138), Expect = 3e-08
Identities = 84/355 (23%), Positives = 139/355 (39%), Gaps = 66/355 (18%)
Query: 47 PHIIFILTDDQGYHDVGYHGSDIETPTLDRLAAKGVKLENYYIQ-PICTPSRSQLLTGRY 105
P+II +LTDDQ DV + T + G N ++ P+C PSRS +LTG+Y
Sbjct: 44 PNIILVLTDDQ---DVELGSMQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTGKY 100
Query: 106 QIHTGLQHSIIRPQQPNCLPLDQV-----TLPQKLQEAGYSTHMVGKWHLGFYRKECLPT 160
+H H+ + P Q T L GY T GK +L Y +P
Sbjct: 101 -VH---NHNTYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGK-YLNEYNGSYVPP 155
Query: 161 RRGFDTFLGSLTGNVDYYTYDNCDGPGVCGFDLHEGENVAWGLSGQYSTMLYAQRASHIL 220
G+ ++G L N +Y Y C G G + S Y T L +
Sbjct: 156 --GWKEWVG-LLKNSRFYNYTLCRN----GVKEKHGSD----YSKDYLTDLITNDSVSFF 204
Query: 221 ASHS---PQRPLFLYVAFQAVHTPLQSPREY-------------------------LYRY 252
+ P RP+ + ++ A H P S +Y + RY
Sbjct: 205 RTSKKMYPHRPVLMVISHAAPHGPEDSAPQYSRLFPNASQHITPSYNYAPNPDKHWIMRY 264
Query: 253 --------RTMGNVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQTFS 304
N+ +RK + +D+++ I L G +N+ I++++D+G +
Sbjct: 265 TGPMKPIHMEFTNMLQRKRLQTLMSVDDSMETIYNMLVETGELDNTYIVYTADHG---YH 321
Query: 305 GGSNWPLRGRKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAG 359
G ++G+ Y E +R +V P ++ +++I D PT++ +AG
Sbjct: 322 IGQFGLVKGKSMPY-EFDIRVPFYVRGPNVEAGCLNPHIVLNI-DLAPTILDIAG 374
>gi|4557659 iduronate-2-sulfatase isoform a precursor [Homo sapiens]
Length = 550
Score = 55.1 bits (131), Expect = 2e-07
Identities = 94/395 (23%), Positives = 142/395 (35%), Gaps = 100/395 (25%)
Query: 48 HIIFILTDDQGYHDVGYHGSDIETPTLDRLAAKGVKLENYYIQP-ICTPSRSQLLTGRYQ 106
+++ I+ DD Y + +P +D+LA+ + +N + Q +C PSR LTGR
Sbjct: 38 NVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRP 97
Query: 107 IHTGLQ--HSIIRPQQPNCLPLDQVTLPQKLQEAGYSTHMVGK-WHLGF--YRKECLPTR 161
T L +S R N T+PQ +E GY T VGK +H G + P
Sbjct: 98 DTTRLYDFNSYWRVHAGNF-----STIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYS 152
Query: 162 RGFDTFLGSLTGNVDYYTYDNCDGPG----------VCGFDLHEGENVAWGLSGQYSTML 211
F + S + Y C GP V D+ EG L + ST
Sbjct: 153 WSFPPYHPS---SEKYENTKTCRGPDGELHANLLCPVDVLDVPEGT-----LPDKQSTEQ 204
Query: 212 YAQRASHILASHSPQRPLFLYVAFQAVHTPLQSPREYLYRYRTMGNVA------------ 259
Q + S S P FL V + H P + P+E+ Y + N+
Sbjct: 205 AIQLLEKMKTSAS---PFFLAVGYHKPHIPFRYPKEFQKLY-PLENITLAPDPEVPDGLP 260
Query: 260 ------------------------------------RRKYAAMVTCMDEAVRNITWALKR 283
R+ Y A V+ +D V + AL
Sbjct: 261 PVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDD 320
Query: 284 YGFYNNSVIIFSSDNGG-----------QTFSGGSNWPL----RGRKGTYWEGGVRGLGF 328
N+++I F+SD+G F ++ PL GR + E G + +
Sbjct: 321 LQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPY 380
Query: 329 V----HSPLLKRKQRTSRALMHITDWYPTLVGLAG 359
+ + L R S L+ + +PTL GLAG
Sbjct: 381 LDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAG 415
>gi|5360208 iduronate-2-sulfatase isoform b precursor [Homo sapiens]
Length = 343
Score = 48.9 bits (115), Expect = 1e-05
Identities = 61/221 (27%), Positives = 88/221 (39%), Gaps = 32/221 (14%)
Query: 48 HIIFILTDDQGYHDVGYHGSDIETPTLDRLAAKGVKLENYYIQP-ICTPSRSQLLTGRYQ 106
+++ I+ DD Y + +P +D+LA+ + +N + Q +C PSR LTGR
Sbjct: 38 NVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRP 97
Query: 107 IHTGLQ--HSIIRPQQPNCLPLDQVTLPQKLQEAGYSTHMVGK-WHLGF--YRKECLPTR 161
T L +S R N T+PQ +E GY T VGK +H G + P
Sbjct: 98 DTTRLYDFNSYWRVHAGNF-----STIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYS 152
Query: 162 RGFDTFLGSLTGNVDYYTYDNCDGPG----------VCGFDLHEGENVAWGLSGQYSTML 211
F + S + Y C GP V D+ EG L + ST
Sbjct: 153 WSFPPYHPS---SEKYENTKTCRGPDGELHANLLCPVDVLDVPEGT-----LPDKQSTEQ 204
Query: 212 YAQRASHILASHSPQRPLFLYVAFQAVHTPLQSPREYLYRY 252
Q + S S P FL V + H P + P+E+ Y
Sbjct: 205 AIQLLEKMKTSAS---PFFLAVGYHKPHIPFRYPKEFQKLY 242
>gi|169217295 PREDICTED: similar to iduronate 2-sulfatase (Hunter
syndrome) [Homo sapiens]
Length = 142
Score = 40.8 bits (94), Expect = 0.003
Identities = 29/82 (35%), Positives = 41/82 (50%), Gaps = 8/82 (9%)
Query: 69 IETPTLDRLAAKGVKLENYYIQP-ICTPSRSQLLTGRYQIHTGLQ--HSIIRPQQPNCLP 125
++ P +D+LA+ + +N + Q +C PSR LTGR T L +S R N
Sbjct: 22 VKAPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNF-- 79
Query: 126 LDQVTLPQKLQEAGYSTHMVGK 147
T+PQ +E GY T VGK
Sbjct: 80 ---STIPQYFKENGYVTMSVGK 98
>gi|39930577 arylsulfatase K [Homo sapiens]
Length = 536
Score = 35.8 bits (81), Expect = 0.11
Identities = 55/253 (21%), Positives = 93/253 (36%), Gaps = 47/253 (18%)
Query: 260 RRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQTFSGGSNWPLRGRKGTYW 319
R Y AM D + I AL + +++I+SSD+G + K + +
Sbjct: 276 RAFYYAMCAETDAMLGEIILALHQLDLLQKTIVIYSSDHGELAMEHRQFY-----KMSMY 330
Query: 320 EGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAGGTTSAADGLDGYDVWPAISE 379
E + P +K + S ++ + D YPT++ +AG L GY + P SE
Sbjct: 331 EASAHVPLLMMGPGIKAGLQVSN-VVSLVDIYPTMLDIAG--IPLPQNLSGYSLLPLSSE 387
Query: 380 GRASPRTEILHNIDPLYNHAQHGSLEGGFGIWNTAVQAAIRVGEWKLLTGDPGYGDWIPP 439
+ + N+ P + L G A +R WK + G I P
Sbjct: 388 TFKNEHK--VKNLHPPW------ILSEFHGCNVNASTYMLRTNHWKYIAYSDGAS--ILP 437
Query: 440 QTLATFPGSWWNLERMASVRQAVWLFNISADPYEREDLAGQRPDVVRTLLARLAEYNRTA 499
Q LF++S+DP E ++A + P++ +L +L
Sbjct: 438 Q-----------------------LFDLSSDPDELTNVAVKFPEITYSLDQKLHSI---- 470
Query: 500 IPVRYPAENPRAH 512
+ YP + H
Sbjct: 471 --INYPKVSASVH 481
Score = 34.7 bits (78), Expect = 0.24
Identities = 31/118 (26%), Positives = 53/118 (44%), Gaps = 10/118 (8%)
Query: 32 PGEAGEQPSAAPPQPPHIIFILTDDQGYHDVGYHGSDI-ETPTLDRLAAKGVKLENYYIQ 90
PG AGEQ A + P+++ +++D + GS + + P ++ + +G N Y
Sbjct: 19 PG-AGEQRRRAA-KAPNVVLVVSDSFDGRLTFHPGSQVVKLPFINFMKTRGTSFLNAYTN 76
Query: 91 -PICTPSRSQLLTGRYQIHTGLQHSIIRPQQPNCLPLDQVTLPQKLQEAGYSTHMVGK 147
PIC PSR+ + +G + H + + PN T ++ GY T GK
Sbjct: 77 SPICCPSRAAMWSGLF-THLTESWNNFKGLDPN-----YTTWMDVMERHGYRTQKFGK 128
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.445
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,122,839
Number of Sequences: 37866
Number of extensions: 1254940
Number of successful extensions: 4636
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 22
Number of HSP's successfully gapped in prelim test: 25
Number of HSP's that attempted gapping in prelim test: 4489
Number of HSP's gapped (non-prelim): 80
length of query: 569
length of database: 18,247,518
effective HSP length: 108
effective length of query: 461
effective length of database: 14,157,990
effective search space: 6526833390
effective search space used: 6526833390
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.