BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|58219792 RAP1B, member of RAS oncogene family [Homo sapiens] (184 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|58219792 RAP1B, member of RAS oncogene family [Homo sapiens] 366 e-102 gi|7661678 RAP1B, member of RAS oncogene family [Homo sapiens] 366 e-102 gi|58331202 RAP1A, member of RAS oncogene family [Homo sapiens] 345 2e-95 gi|4506413 RAP1A, member of RAS oncogene family [Homo sapiens] 345 2e-95 gi|38201690 RAP2B, member of RAS oncogene family [Homo sapiens] 224 3e-59 gi|10518344 RAP2A, member of RAS oncogene family [Homo sapiens] 223 9e-59 gi|32129209 RAP2C, member of RAS oncogene family [Homo sapiens] 221 3e-58 gi|15718761 c-K-ras2 protein isoform b precursor [Homo sapiens] 201 3e-52 gi|15718763 c-K-ras2 protein isoform a precursor [Homo sapiens] 196 1e-50 gi|194363762 v-Ha-ras Harvey rat sarcoma viral oncogene homolog ... 196 1e-50 gi|4885425 v-Ha-ras Harvey rat sarcoma viral oncogene homolog is... 196 1e-50 gi|4505451 neuroblastoma RAS viral (v-ras) oncogene homolog [Hom... 192 2e-49 gi|21361416 related RAS viral (r-ras) oncogene homolog 2 isoform... 186 1e-47 gi|34222246 v-Ha-ras Harvey rat sarcoma viral oncogene homolog i... 182 1e-46 gi|33946329 ras related v-ral simian leukemia viral oncogene hom... 179 1e-45 gi|145386506 muscle RAS oncogene homolog [Homo sapiens] 179 1e-45 gi|145386562 muscle RAS oncogene homolog [Homo sapiens] 179 1e-45 gi|5902050 Ras-like without CAAX 1 [Homo sapiens] 178 3e-45 gi|4506533 Ras-like without CAAX 2 [Homo sapiens] 175 2e-44 gi|4506405 v-ral simian leukemia viral oncogene homolog B [Homo ... 170 6e-43 gi|5454028 related RAS viral (r-ras) oncogene homolog [Homo sapi... 169 2e-42 gi|21703367 Di-Ras2 [Homo sapiens] 155 2e-38 gi|14249704 RAS-like, estrogen-regulated, growth inhibitor [Homo... 147 5e-36 gi|21553323 DIRAS family, GTP-binding RAS-like 1 [Homo sapiens] 146 9e-36 gi|169160721 PREDICTED: similar to related RAS viral (r-ras) onc... 144 6e-35 gi|169161589 PREDICTED: similar to related RAS viral (r-ras) onc... 144 6e-35 gi|169161292 PREDICTED: similar to related RAS viral (r-ras) onc... 144 6e-35 gi|5032041 Ras homolog enriched in brain [Homo sapiens] 132 2e-31 gi|106507164 RAB12, member RAS oncogene family [Homo sapiens] 115 3e-26 gi|22027486 RASD family, member 2 [Homo sapiens] 114 4e-26 >gi|58219792 RAP1B, member of RAS oncogene family [Homo sapiens] Length = 184 Score = 366 bits (940), Expect = e-102 Identities = 184/184 (100%), Positives = 184/184 (100%) Query: 1 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAG 60 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAG Sbjct: 1 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAG 60 Query: 61 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDL 120 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDL Sbjct: 61 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDL 120 Query: 121 EDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSS 180 EDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSS Sbjct: 121 EDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSS 180 Query: 181 CQLL 184 CQLL Sbjct: 181 CQLL 184 >gi|7661678 RAP1B, member of RAS oncogene family [Homo sapiens] Length = 184 Score = 366 bits (940), Expect = e-102 Identities = 184/184 (100%), Positives = 184/184 (100%) Query: 1 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAG 60 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAG Sbjct: 1 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAG 60 Query: 61 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDL 120 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDL Sbjct: 61 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDL 120 Query: 121 EDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSS 180 EDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSS Sbjct: 121 EDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSS 180 Query: 181 CQLL 184 CQLL Sbjct: 181 CQLL 184 >gi|58331202 RAP1A, member of RAS oncogene family [Homo sapiens] Length = 184 Score = 345 bits (884), Expect = 2e-95 Identities = 175/184 (95%), Positives = 176/184 (95%) Query: 1 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAG 60 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVD QQCMLEILDTAG Sbjct: 1 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAG 60 Query: 61 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDL 120 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDT+DVPMILVGNKCDL Sbjct: 61 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDL 120 Query: 121 EDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSS 180 EDERVVGKEQGQNLARQW NCAFLESSAKSKINVNEIFYDLVRQINRKTPV K KK S Sbjct: 121 EDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKS 180 Query: 181 CQLL 184 C LL Sbjct: 181 CLLL 184 >gi|4506413 RAP1A, member of RAS oncogene family [Homo sapiens] Length = 184 Score = 345 bits (884), Expect = 2e-95 Identities = 175/184 (95%), Positives = 176/184 (95%) Query: 1 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAG 60 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVD QQCMLEILDTAG Sbjct: 1 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAG 60 Query: 61 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDL 120 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDT+DVPMILVGNKCDL Sbjct: 61 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDL 120 Query: 121 EDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSS 180 EDERVVGKEQGQNLARQW NCAFLESSAKSKINVNEIFYDLVRQINRKTPV K KK S Sbjct: 121 EDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKS 180 Query: 181 CQLL 184 C LL Sbjct: 181 CLLL 184 >gi|38201690 RAP2B, member of RAS oncogene family [Homo sapiens] Length = 183 Score = 224 bits (571), Expect = 3e-59 Identities = 113/184 (61%), Positives = 144/184 (78%), Gaps = 1/184 (0%) Query: 1 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAG 60 MREYK+VVLGSGGVGKSALTVQFV G F+EKYDPTIED YRK++EVD+ +LEILDTAG Sbjct: 1 MREYKVVVLGSGGVGKSALTVQFVTGSFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG 60 Query: 61 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDL 120 TEQF +MRDLY+KNGQGF LVYS+ Q +F D++ +R+QI+RVK + VPMILVGNK DL Sbjct: 61 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYERVPMILVGNKVDL 120 Query: 121 EDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSS 180 E ER V +G+ LA +W +C F+E+SAK+K +V+E+F ++VRQ+N G S+ Sbjct: 121 EGEREVSYGEGKALAEEW-SCPFMETSAKNKASVDELFAEIVRQMNYAAQPNGDEGCCSA 179 Query: 181 CQLL 184 C +L Sbjct: 180 CVIL 183 >gi|10518344 RAP2A, member of RAS oncogene family [Homo sapiens] Length = 183 Score = 223 bits (567), Expect = 9e-59 Identities = 109/166 (65%), Positives = 136/166 (81%), Gaps = 1/166 (0%) Query: 1 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAG 60 MREYK+VVLGSGGVGKSALTVQFV G F+EKYDPTIED YRK++EVD+ +LEILDTAG Sbjct: 1 MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG 60 Query: 61 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDL 120 TEQF +MRDLY+KNGQGF LVYS+ Q +F D++ +R+QI+RVK + VP+ILVGNK DL Sbjct: 61 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYEKVPVILVGNKVDL 120 Query: 121 EDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQIN 166 E ER V +G+ LA +W C F+E+SAKSK V+E+F ++VRQ+N Sbjct: 121 ESEREVSSSEGRALAEEW-GCPFMETSAKSKTMVDELFAEIVRQMN 165 >gi|32129209 RAP2C, member of RAS oncogene family [Homo sapiens] Length = 183 Score = 221 bits (563), Expect = 3e-58 Identities = 109/166 (65%), Positives = 137/166 (82%), Gaps = 1/166 (0%) Query: 1 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAG 60 MREYK+VVLGSGGVGKSALTVQFV G F+EKYDPTIED YRK++EVD+ +LEILDTAG Sbjct: 1 MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG 60 Query: 61 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDL 120 TEQF +MRDLY+KNGQGF LVYS+ Q +F D++ +R+QI+RVK + VP+ILVGNK DL Sbjct: 61 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIVRVKRYEKVPLILVGNKVDL 120 Query: 121 EDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQIN 166 E ER V +G+ LA++W C F+E+SAKSK V+E+F ++VRQ+N Sbjct: 121 EPEREVMSSEGRALAQEW-GCPFMETSAKSKSMVDELFAEIVRQMN 165 >gi|15718761 c-K-ras2 protein isoform b precursor [Homo sapiens] Length = 188 Score = 201 bits (511), Expect = 3e-52 Identities = 102/183 (55%), Positives = 136/183 (74%), Gaps = 5/183 (2%) Query: 1 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAG 60 M EYKLVV+G+GGVGKSALT+Q +Q FV++YDPTIEDSYRKQV +D + C+L+ILDTAG Sbjct: 1 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60 Query: 61 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDL 120 E+++AMRD YM+ G+GF V++I +F D+ REQI RVKD++DVPM+LVGNKCDL Sbjct: 61 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120 Query: 121 EDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINR---KTPVPGKARK 177 R V +Q Q+LAR + F+E+SAK++ V++ FY LVR+I + K GK +K Sbjct: 121 -PSRTVDTKQAQDLARSY-GIPFIETSAKTRQGVDDAFYTLVREIRKHKEKMSKDGKKKK 178 Query: 178 KSS 180 K S Sbjct: 179 KKS 181 >gi|15718763 c-K-ras2 protein isoform a precursor [Homo sapiens] Length = 189 Score = 196 bits (497), Expect = 1e-50 Identities = 96/167 (57%), Positives = 128/167 (76%), Gaps = 2/167 (1%) Query: 1 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAG 60 M EYKLVV+G+GGVGKSALT+Q +Q FV++YDPTIEDSYRKQV +D + C+L+ILDTAG Sbjct: 1 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60 Query: 61 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDL 120 E+++AMRD YM+ G+GF V++I +F D+ REQI RVKD++DVPM+LVGNKCDL Sbjct: 61 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120 Query: 121 EDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINR 167 R V +Q Q+LAR + F+E+SAK++ V + FY LVR+I + Sbjct: 121 -PSRTVDTKQAQDLARSY-GIPFIETSAKTRQRVEDAFYTLVREIRQ 165 >gi|194363762 v-Ha-ras Harvey rat sarcoma viral oncogene homolog isoform 1 [Homo sapiens] Length = 189 Score = 196 bits (497), Expect = 1e-50 Identities = 96/167 (57%), Positives = 127/167 (76%), Gaps = 2/167 (1%) Query: 1 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAG 60 M EYKLVV+G+GGVGKSALT+Q +Q FV++YDPTIEDSYRKQV +D + C+L+ILDTAG Sbjct: 1 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60 Query: 61 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDL 120 E+++AMRD YM+ G+GF V++I +F D+ REQI RVKD+DDVPM+LVGNKCDL Sbjct: 61 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL 120 Query: 121 EDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINR 167 R V Q Q+LAR + ++E+SAK++ V + FY LVR+I + Sbjct: 121 A-ARTVESRQAQDLARSY-GIPYIETSAKTRQGVEDAFYTLVREIRQ 165 >gi|4885425 v-Ha-ras Harvey rat sarcoma viral oncogene homolog isoform 1 [Homo sapiens] Length = 189 Score = 196 bits (497), Expect = 1e-50 Identities = 96/167 (57%), Positives = 127/167 (76%), Gaps = 2/167 (1%) Query: 1 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAG 60 M EYKLVV+G+GGVGKSALT+Q +Q FV++YDPTIEDSYRKQV +D + C+L+ILDTAG Sbjct: 1 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60 Query: 61 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDL 120 E+++AMRD YM+ G+GF V++I +F D+ REQI RVKD+DDVPM+LVGNKCDL Sbjct: 61 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL 120 Query: 121 EDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINR 167 R V Q Q+LAR + ++E+SAK++ V + FY LVR+I + Sbjct: 121 A-ARTVESRQAQDLARSY-GIPYIETSAKTRQGVEDAFYTLVREIRQ 165 >gi|4505451 neuroblastoma RAS viral (v-ras) oncogene homolog [Homo sapiens] Length = 189 Score = 192 bits (487), Expect = 2e-49 Identities = 95/167 (56%), Positives = 126/167 (75%), Gaps = 2/167 (1%) Query: 1 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAG 60 M EYKLVV+G+GGVGKSALT+Q +Q FV++YDPTIEDSYRKQV +D + C+L+ILDTAG Sbjct: 1 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60 Query: 61 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDL 120 E+++AMRD YM+ G+GF V++I +F D+ REQI RVKD+DDVPM+LVGNKCDL Sbjct: 61 QEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDL 120 Query: 121 EDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINR 167 R V +Q LA+ + F+E+SAK++ V + FY LVR+I + Sbjct: 121 -PTRTVDTKQAHELAKSY-GIPFIETSAKTRQGVEDAFYTLVREIRQ 165 >gi|21361416 related RAS viral (r-ras) oncogene homolog 2 isoform a [Homo sapiens] Length = 204 Score = 186 bits (472), Expect = 1e-47 Identities = 90/165 (54%), Positives = 125/165 (75%), Gaps = 1/165 (0%) Query: 3 EYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAGTE 62 +Y+LVV+G GGVGKSALT+QF+Q FV YDPTIEDSY KQ +D + L+ILDTAG E Sbjct: 14 KYRLVVVGGGGVGKSALTIQFIQSYFVTDYDPTIEDSYTKQCVIDDRAARLDILDTAGQE 73 Query: 63 QFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLED 122 +F AMR+ YM+ G+GF LV+S+T + +F ++ + QILRVKD D+ PMIL+GNK DL+ Sbjct: 74 EFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKFQRQILRVKDRDEFPMILIGNKADLDH 133 Query: 123 ERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINR 167 +R V +E+GQ LARQ ++E+SAK ++NV++ F++LVR I + Sbjct: 134 QRQVTQEEGQQLARQL-KVTYMEASAKIRMNVDQAFHELVRVIRK 177 >gi|34222246 v-Ha-ras Harvey rat sarcoma viral oncogene homolog isoform 2 [Homo sapiens] Length = 170 Score = 182 bits (463), Expect = 1e-46 Identities = 89/151 (58%), Positives = 117/151 (77%), Gaps = 2/151 (1%) Query: 1 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAG 60 M EYKLVV+G+GGVGKSALT+Q +Q FV++YDPTIEDSYRKQV +D + C+L+ILDTAG Sbjct: 1 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60 Query: 61 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDL 120 E+++AMRD YM+ G+GF V++I +F D+ REQI RVKD+DDVPM+LVGNKCDL Sbjct: 61 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL 120 Query: 121 EDERVVGKEQGQNLARQWNNCAFLESSAKSK 151 R V Q Q+LAR + ++E+SAK++ Sbjct: 121 A-ARTVESRQAQDLARSY-GIPYIETSAKTR 149 >gi|33946329 ras related v-ral simian leukemia viral oncogene homolog A [Homo sapiens] Length = 206 Score = 179 bits (454), Expect = 1e-45 Identities = 89/181 (49%), Positives = 131/181 (72%), Gaps = 6/181 (3%) Query: 4 YKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAGTEQ 63 +K++++GSGGVGKSALT+QF+ FVE Y+PT DSYRK+V +D ++ ++ILDTAG E Sbjct: 15 HKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQED 74 Query: 64 FTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDE 123 + A+RD Y ++G+GF V+SIT +F D REQILRVK+ ++VP +LVGNK DLED+ Sbjct: 75 YAAIRDNYFRSGEGFLCVFSITEMESFAATADFREQILRVKEDENVPFLLVGNKSDLEDK 134 Query: 124 RVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRK-----TPVPGKARKK 178 R V E+ +N A QW N ++E+SAK++ NV+++F+DL+R+I + GK ++K Sbjct: 135 RQVSVEEAKNRAEQW-NVNYVETSAKTRANVDKVFFDLMREIRARKMEDSKEKNGKKKRK 193 Query: 179 S 179 S Sbjct: 194 S 194 >gi|145386506 muscle RAS oncogene homolog [Homo sapiens] Length = 208 Score = 179 bits (454), Expect = 1e-45 Identities = 91/178 (51%), Positives = 127/178 (71%), Gaps = 2/178 (1%) Query: 4 YKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAGTEQ 63 YKLVV+G GGVGKSALT+QF Q IFV YDPTIEDSY K E+D Q +L++LDTAG E+ Sbjct: 14 YKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQWAILDVLDTAGQEE 73 Query: 64 FTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDE 123 F+AMR+ YM+ G GF +VYS+T +++F + + ILRVKD + PMILV NK DL Sbjct: 74 FSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFPMILVANKVDLMHL 133 Query: 124 RVVGKEQGQNLARQWNNCAFLESSAKS-KINVNEIFYDLVRQINRKTPVPGKARKKSS 180 R + +EQG+ +A + +N ++E+SAK +NV++ F+DLVR I ++ P + +KK + Sbjct: 134 RKITREQGKEMATK-HNIPYIETSAKDPPLNVDKAFHDLVRVIRQQIPEKSQKKKKKT 190 >gi|145386562 muscle RAS oncogene homolog [Homo sapiens] Length = 208 Score = 179 bits (454), Expect = 1e-45 Identities = 91/178 (51%), Positives = 127/178 (71%), Gaps = 2/178 (1%) Query: 4 YKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAGTEQ 63 YKLVV+G GGVGKSALT+QF Q IFV YDPTIEDSY K E+D Q +L++LDTAG E+ Sbjct: 14 YKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQWAILDVLDTAGQEE 73 Query: 64 FTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDE 123 F+AMR+ YM+ G GF +VYS+T +++F + + ILRVKD + PMILV NK DL Sbjct: 74 FSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFPMILVANKVDLMHL 133 Query: 124 RVVGKEQGQNLARQWNNCAFLESSAKS-KINVNEIFYDLVRQINRKTPVPGKARKKSS 180 R + +EQG+ +A + +N ++E+SAK +NV++ F+DLVR I ++ P + +KK + Sbjct: 134 RKITREQGKEMATK-HNIPYIETSAKDPPLNVDKAFHDLVRVIRQQIPEKSQKKKKKT 190 >gi|5902050 Ras-like without CAAX 1 [Homo sapiens] Length = 219 Score = 178 bits (451), Expect = 3e-45 Identities = 88/179 (49%), Positives = 131/179 (73%), Gaps = 1/179 (0%) Query: 2 REYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAGT 61 REYKLV+LG+GGVGKSA+T+QF+ F E +DPTIED+Y+ ++ +D + L+ILDTAG Sbjct: 20 REYKLVMLGAGGVGKSAMTMQFISHRFPEDHDPTIEDAYKIRIRIDDEPANLDILDTAGQ 79 Query: 62 EQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLE 121 +FTAMRD YM+ G+GF + YSIT + +F+++++ ++ I RV+ TDD P++LVGNK DL+ Sbjct: 80 AEFTAMRDQYMRAGEGFIICYSITDRRSFHEVREFKQLIYRVRRTDDTPVVLVGNKSDLK 139 Query: 122 DERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSS 180 R V KE+G LAR++ +C F E+SA + ++++F+ LVR+I RK A +K S Sbjct: 140 QLRQVTKEEGLALAREF-SCPFFETSAAYRYYIDDVFHALVREIRRKEKEAVLAMEKKS 197 >gi|4506533 Ras-like without CAAX 2 [Homo sapiens] Length = 217 Score = 175 bits (444), Expect = 2e-44 Identities = 83/177 (46%), Positives = 126/177 (71%), Gaps = 1/177 (0%) Query: 2 REYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAGT 61 REYK+V+LG+GGVGKSA+T+QF+ F + +DPTIED+Y+ QV +D + L+ILDTAG Sbjct: 19 REYKVVMLGAGGVGKSAMTMQFISHQFPDYHDPTIEDAYKTQVRIDNEPAYLDILDTAGQ 78 Query: 62 EQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLE 121 +FTAMR+ YM+ G+GF + YS+T + +F + +E I +V+ T ++P++LVGNK DLE Sbjct: 79 AEFTAMREQYMRGGEGFIICYSVTDRQSFQEAAKFKELIFQVRHTYEIPLVLVGNKIDLE 138 Query: 122 DERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKK 178 R V E+G +LA+++ NC F E+SA + +++ F+ LVR+I +K +P KK Sbjct: 139 QFRQVSTEEGLSLAQEY-NCGFFETSAALRFCIDDAFHGLVREIRKKESMPSLMEKK 194 >gi|4506405 v-ral simian leukemia viral oncogene homolog B [Homo sapiens] Length = 206 Score = 170 bits (431), Expect = 6e-43 Identities = 86/180 (47%), Positives = 130/180 (72%), Gaps = 4/180 (2%) Query: 4 YKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAGTEQ 63 +K++++GSGGVGKSALT+QF+ FVE Y+PT DSYRK+V +D ++ ++ILDTAG E Sbjct: 15 HKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQED 74 Query: 64 FTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVK-DTDDVPMILVGNKCDLED 122 + A+RD Y ++G+GF LV+SIT +F + REQILRVK + D +P+++VGNK DLE+ Sbjct: 75 YAAIRDNYFRSGEGFLLVFSITEHESFTATAEFREQILRVKAEEDKIPLLVVGNKSDLEE 134 Query: 123 ERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKAR--KKSS 180 R V E+ ++ A +W ++E+SAK++ NV+++F+DL+R+I K K + KKSS Sbjct: 135 RRQVPVEEARSKAEEW-GVQYVETSAKTRANVDKVFFDLMREIRTKKMSENKDKNGKKSS 193 >gi|5454028 related RAS viral (r-ras) oncogene homolog [Homo sapiens] Length = 218 Score = 169 bits (427), Expect = 2e-42 Identities = 86/164 (52%), Positives = 114/164 (69%), Gaps = 1/164 (0%) Query: 4 YKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAGTEQ 63 +KLVV+G GGVGKSALT+QF+Q FV YDPTIEDSY K VD L+ILDTAG E+ Sbjct: 30 HKLVVVGGGGVGKSALTIQFIQSYFVSDYDPTIEDSYTKICSVDGIPARLDILDTAGQEE 89 Query: 64 FTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDE 123 F AMR+ YM+ G GF LV++I + +FN++ L QILRVKD DD P++LVGNK DLE + Sbjct: 90 FGAMREQYMRAGHGFLLVFAINDRQSFNEVGKLFTQILRVKDRDDFPVVLVGNKADLESQ 149 Query: 124 RVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINR 167 R V + + ++ A+ E+SAK ++NV+E F LVR + + Sbjct: 150 RQVPRSEASAFGAS-HHVAYFEASAKLRLNVDEAFEQLVRAVRK 192 >gi|21703367 Di-Ras2 [Homo sapiens] Length = 199 Score = 155 bits (391), Expect = 2e-38 Identities = 79/180 (43%), Positives = 116/180 (64%), Gaps = 5/180 (2%) Query: 3 EYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAGTE 62 +Y++ V G+GGVGKS+L ++FV+G F E Y PT+ED+YR+ + D C L+I DT G+ Sbjct: 7 DYRVAVFGAGGVGKSSLVLRFVKGTFRESYIPTVEDTYRQVISCDKSICTLQITDTTGSH 66 Query: 63 QFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVK-DTDDVPMILVGNKCDLE 121 QF AM+ L + G F LVYSIT++ + +L+ + EQI +K D + +P++LVGNKCD Sbjct: 67 QFPAMQRLSISKGHAFILVYSITSRQSLEELKPIYEQICEIKGDVESIPIMLVGNKCDES 126 Query: 122 DERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKT---PVPGKARKK 178 R V + + LAR W CAF+E+SAK NV E+F +L+ R+T + GK K+ Sbjct: 127 PSREVQSSEAEALARTW-KCAFMETSAKLNHNVKELFQELLNLEKRRTVSLQIDGKKSKQ 185 >gi|14249704 RAS-like, estrogen-regulated, growth inhibitor [Homo sapiens] Length = 199 Score = 147 bits (371), Expect = 5e-36 Identities = 80/179 (44%), Positives = 115/179 (64%), Gaps = 3/179 (1%) Query: 3 EYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAGTE 62 E KL + G GVGKSAL V+F+ F+ +YDPT+E +YR Q +D + +EILDTAG E Sbjct: 6 EVKLAIFGRAGVGKSALVVRFLTKRFIWEYDPTLESTYRHQATIDDEVVSMEILDTAGQE 65 Query: 63 QFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLED 122 T R+ +M+ G+GF LVY IT + +F ++ L+ + +K +V +ILVGNK DL+ Sbjct: 66 D-TIQREGHMRWGEGFVLVYDITDRGSFEEVLPLKNILDEIKKPKNVTLILVGNKADLDH 124 Query: 123 ERVVGKEQGQNLARQWNNCAFLESSA-KSKINVNEIFYDLVRQINRKTPVPGKARKKSS 180 R V E+G+ LA + CAF E SA + N+ EIFY+L R++ R+ V GK R++SS Sbjct: 125 SRQVSTEEGEKLATEL-ACAFYECSACTGEGNITEIFYELCREVRRRRMVQGKTRRRSS 182 >gi|21553323 DIRAS family, GTP-binding RAS-like 1 [Homo sapiens] Length = 198 Score = 146 bits (369), Expect = 9e-36 Identities = 72/167 (43%), Positives = 114/167 (68%), Gaps = 3/167 (1%) Query: 3 EYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAGTE 62 +Y++VV G+GGVGKS+L ++FV+G F + Y PTIED+YR+ + D C L+I DT G+ Sbjct: 7 DYRVVVFGAGGVGKSSLVLRFVKGTFRDTYIPTIEDTYRQVISCDKSVCTLQITDTTGSH 66 Query: 63 QFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVK-DTDDVPMILVGNKCDLE 121 QF AM+ L + G F LV+S+T++ + +L + + I+++K +D+P++LVGNKCD E Sbjct: 67 QFPAMQRLSISKGHAFILVFSVTSKQSLEELGPIYKLIVQIKGSVEDIPVMLVGNKCD-E 125 Query: 122 DERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRK 168 +R V + Q +A++W CAF+E+SAK NV E+F +L+ R+ Sbjct: 126 TQREVDTREAQAVAQEW-KCAFMETSAKMNYNVKELFQELLTLETRR 171 >gi|169160721 PREDICTED: similar to related RAS viral (r-ras) oncogene homolog 2 [Homo sapiens] Length = 185 Score = 144 bits (362), Expect = 6e-35 Identities = 70/143 (48%), Positives = 102/143 (71%), Gaps = 1/143 (0%) Query: 25 QGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSI 84 + FV YDPT EDSY KQ +D + L+ILDTAG E+ AMR+ YM+ G+GF LV+S+ Sbjct: 17 ESYFVTDYDPTNEDSYTKQCVIDDRAARLDILDTAGQEELGAMREQYMRTGEGFLLVFSV 76 Query: 85 TAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDERVVGKEQGQNLARQWNNCAFL 144 T + +F ++ + QILRVKD D+ PMIL+GNK DL+ +R V +E+G+ LARQ ++ Sbjct: 77 TDRGSFEEIYKFQRQILRVKDRDEFPMILIGNKADLDHQRQVTQEEGRQLARQL-KVTYM 135 Query: 145 ESSAKSKINVNEIFYDLVRQINR 167 E+SAK ++NV++ F++LVR I + Sbjct: 136 EASAKIRMNVDQAFHELVRVIRK 158 >gi|169161589 PREDICTED: similar to related RAS viral (r-ras) oncogene homolog 2 [Homo sapiens] Length = 185 Score = 144 bits (362), Expect = 6e-35 Identities = 70/143 (48%), Positives = 102/143 (71%), Gaps = 1/143 (0%) Query: 25 QGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSI 84 + FV YDPT EDSY KQ +D + L+ILDTAG E+ AMR+ YM+ G+GF LV+S+ Sbjct: 17 ESYFVTDYDPTNEDSYTKQCVIDDRAARLDILDTAGQEELGAMREQYMRTGEGFLLVFSV 76 Query: 85 TAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDERVVGKEQGQNLARQWNNCAFL 144 T + +F ++ + QILRVKD D+ PMIL+GNK DL+ +R V +E+G+ LARQ ++ Sbjct: 77 TDRGSFEEIYKFQRQILRVKDRDEFPMILIGNKADLDHQRQVTQEEGRQLARQL-KVTYM 135 Query: 145 ESSAKSKINVNEIFYDLVRQINR 167 E+SAK ++NV++ F++LVR I + Sbjct: 136 EASAKIRMNVDQAFHELVRVIRK 158 >gi|169161292 PREDICTED: similar to related RAS viral (r-ras) oncogene homolog 2 [Homo sapiens] Length = 185 Score = 144 bits (362), Expect = 6e-35 Identities = 70/143 (48%), Positives = 102/143 (71%), Gaps = 1/143 (0%) Query: 25 QGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSI 84 + FV YDPT EDSY KQ +D + L+ILDTAG E+ AMR+ YM+ G+GF LV+S+ Sbjct: 17 ESYFVTDYDPTNEDSYTKQCVIDDRAARLDILDTAGQEELGAMREQYMRTGEGFLLVFSV 76 Query: 85 TAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDERVVGKEQGQNLARQWNNCAFL 144 T + +F ++ + QILRVKD D+ PMIL+GNK DL+ +R V +E+G+ LARQ ++ Sbjct: 77 TDRGSFEEIYKFQRQILRVKDRDEFPMILIGNKADLDHQRQVTQEEGRQLARQL-KVTYM 135 Query: 145 ESSAKSKINVNEIFYDLVRQINR 167 E+SAK ++NV++ F++LVR I + Sbjct: 136 EASAKIRMNVDQAFHELVRVIRK 158 >gi|5032041 Ras homolog enriched in brain [Homo sapiens] Length = 184 Score = 132 bits (332), Expect = 2e-31 Identities = 68/180 (37%), Positives = 113/180 (62%), Gaps = 3/180 (1%) Query: 5 KLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAGTEQF 64 K+ +LG VGKS+LT+QFV+G FV+ YDPTIE+++ K + V+ Q+ L+++DTAG +++ Sbjct: 8 KIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVDTAGQDEY 67 Query: 65 TAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDER 124 + Y + G+ LVYS+T+ +F ++ + ++L + +P++LVGNK DL ER Sbjct: 68 SIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNKKDLHMER 127 Query: 125 VVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSSCQLL 184 V+ E+G+ LA W N AFLESSAK ++F ++ + + + KSSC ++ Sbjct: 128 VISYEEGKALAESW-NAAFLESSAKENQTAVDVFRRIILEAEKMDGAASQG--KSSCSVM 184 >gi|106507164 RAB12, member RAS oncogene family [Homo sapiens] Length = 244 Score = 115 bits (287), Expect = 3e-26 Identities = 62/168 (36%), Positives = 101/168 (60%), Gaps = 2/168 (1%) Query: 5 KLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYR-KQVEVDAQQCMLEILDTAGTEQ 63 +++++GS GVGK++L +F F E T+ ++ K VE+ ++ L+I DTAG E+ Sbjct: 44 QVIIIGSRGVGKTSLMERFTDDTFCEACKSTVGVDFKIKTVELRGKKIRLQIWDTAGQER 103 Query: 64 FTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDE 123 F ++ Y ++ +G LVY IT + TF+DL + I + ++D ++LVGNK D E + Sbjct: 104 FNSITSAYYRSAKGIILVYDITKKETFDDLPKWMKMIDKYA-SEDAELLLVGNKLDCETD 162 Query: 124 RVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPV 171 R + ++QG+ A+Q F E+SAK NV+EIF LV I +K P+ Sbjct: 163 REITRQQGEKFAQQITGMRFCEASAKDNFNVDEIFLKLVDDILKKMPL 210 >gi|22027486 RASD family, member 2 [Homo sapiens] Length = 266 Score = 114 bits (286), Expect = 4e-26 Identities = 66/167 (39%), Positives = 100/167 (59%), Gaps = 9/167 (5%) Query: 4 YKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAGTEQ 63 Y++VVLG+ VGKS++ +F+ G F ++Y PTIED +RK + L+ILDT+G Sbjct: 20 YRMVVLGASRVGKSSIVSRFLNGRFEDQYTPTIEDFHRKVYNIRGDMYQLDILDTSGNHP 79 Query: 64 FTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRV--------KDTDDVPMILVG 115 F AMR L + G F LV+S+ + +F++++ L++QIL V K+ ++PM++ G Sbjct: 80 FPAMRRLSILTGDVFILVFSLDNRESFDEVKRLQKQILEVKSCLKNKTKEAAELPMVICG 139 Query: 116 NKCDL-EDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDL 161 NK D E R V + + L NCA+ E SAK NV+E+FY L Sbjct: 140 NKNDHGELCRQVPTTEAELLVSGDENCAYFEVSAKKNTNVDEMFYVL 186 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.318 0.134 0.379 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 6,299,903 Number of Sequences: 37866 Number of extensions: 238112 Number of successful extensions: 1088 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 200 Number of HSP's successfully gapped in prelim test: 41 Number of HSP's that attempted gapping in prelim test: 619 Number of HSP's gapped (non-prelim): 249 length of query: 184 length of database: 18,247,518 effective HSP length: 96 effective length of query: 88 effective length of database: 14,612,382 effective search space: 1285889616 effective search space used: 1285889616 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 58 (26.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.