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Search of human proteins with 134152694
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|134152694 guanylate cyclase 2F [Homo sapiens]
(1108 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|134152694 guanylate cyclase 2F [Homo sapiens] 2235 0.0
gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Hom... 1055 0.0
gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens] 504 e-142
gi|167830411 natriuretic peptide receptor 1 [Homo sapiens] 504 e-142
gi|222080083 guanylate cyclase 2C [Homo sapiens] 426 e-119
gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Ho... 171 3e-42
gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 171 3e-42
gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 171 3e-42
gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Hom... 171 3e-42
gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 171 3e-42
gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens] 167 4e-41
gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Ho... 167 7e-41
gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens] 160 5e-39
gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens] 118 3e-26
gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens] 118 3e-26
gi|4557257 adenylate cyclase 8 [Homo sapiens] 115 2e-25
gi|34486092 adenylate cyclase 5 [Homo sapiens] 115 2e-25
gi|31083193 adenylate cyclase 1 [Homo sapiens] 115 3e-25
gi|4557255 adenylate cyclase 7 [Homo sapiens] 113 9e-25
gi|115387102 adenylate cyclase 2 [Homo sapiens] 113 1e-24
gi|24497587 adenylate cyclase 4 [Homo sapiens] 110 6e-24
gi|57242761 receptor (TNFRSF)-interacting serine-threonine kinas... 105 2e-22
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 103 9e-22
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 103 9e-22
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 101 4e-21
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 101 4e-21
gi|50959205 adenylate cyclase 9 [Homo sapiens] 100 6e-21
gi|148536830 adenylate cyclase 3 [Homo sapiens] 100 1e-20
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 99 3e-20
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 99 3e-20
>gi|134152694 guanylate cyclase 2F [Homo sapiens]
Length = 1108
Score = 2235 bits (5792), Expect = 0.0
Identities = 1108/1108 (100%), Positives = 1108/1108 (100%)
Query: 1 MFLGLGRFSRLVLWFAAFRKLLGHHGLASAKFLWCLCLLSVMSLPQQVWTLPYKIGVVGP 60
MFLGLGRFSRLVLWFAAFRKLLGHHGLASAKFLWCLCLLSVMSLPQQVWTLPYKIGVVGP
Sbjct: 1 MFLGLGRFSRLVLWFAAFRKLLGHHGLASAKFLWCLCLLSVMSLPQQVWTLPYKIGVVGP 60
Query: 61 WACDSLFSKALPEVAARLAIERINRDPSFDLSYSFEYVILNEDCQTSRALSSFISHHQMA 120
WACDSLFSKALPEVAARLAIERINRDPSFDLSYSFEYVILNEDCQTSRALSSFISHHQMA
Sbjct: 61 WACDSLFSKALPEVAARLAIERINRDPSFDLSYSFEYVILNEDCQTSRALSSFISHHQMA 120
Query: 121 SGFIGPTNPGYCEAASLLGNSWDKGIFSWACVNYELDNKISYPTFSRTLPSPIRVLVTVM 180
SGFIGPTNPGYCEAASLLGNSWDKGIFSWACVNYELDNKISYPTFSRTLPSPIRVLVTVM
Sbjct: 121 SGFIGPTNPGYCEAASLLGNSWDKGIFSWACVNYELDNKISYPTFSRTLPSPIRVLVTVM 180
Query: 181 KYFQWAHAGVISSDEDIWVHTANRVASALRSHGLPVGVVLTTGQDSQSMRKALQRIHQAD 240
KYFQWAHAGVISSDEDIWVHTANRVASALRSHGLPVGVVLTTGQDSQSMRKALQRIHQAD
Sbjct: 181 KYFQWAHAGVISSDEDIWVHTANRVASALRSHGLPVGVVLTTGQDSQSMRKALQRIHQAD 240
Query: 241 RIRIIIMCMHSALIGGETQMHLLECAHDLKMTDGTYVFVPYDALLYSLPYKHTPYRVLRN 300
RIRIIIMCMHSALIGGETQMHLLECAHDLKMTDGTYVFVPYDALLYSLPYKHTPYRVLRN
Sbjct: 241 RIRIIIMCMHSALIGGETQMHLLECAHDLKMTDGTYVFVPYDALLYSLPYKHTPYRVLRN 300
Query: 301 NPKLREAYDAVLTITVESQEKTFYQAFTEAAARGEIPEKLEFDQVSPLFGTIYNSIYFIA 360
NPKLREAYDAVLTITVESQEKTFYQAFTEAAARGEIPEKLEFDQVSPLFGTIYNSIYFIA
Sbjct: 301 NPKLREAYDAVLTITVESQEKTFYQAFTEAAARGEIPEKLEFDQVSPLFGTIYNSIYFIA 360
Query: 361 QAMNNAMKENGQAGAASLVQHSRNMQFHGFNQLMRTDSNGNGISEYVILDTNLKEWELHS 420
QAMNNAMKENGQAGAASLVQHSRNMQFHGFNQLMRTDSNGNGISEYVILDTNLKEWELHS
Sbjct: 361 QAMNNAMKENGQAGAASLVQHSRNMQFHGFNQLMRTDSNGNGISEYVILDTNLKEWELHS 420
Query: 421 TYTVDMEMELLRFGGTPIHFPGGRPPRADAKCWFAEGKICHGGIDPAFAMMVCLTLLIAL 480
TYTVDMEMELLRFGGTPIHFPGGRPPRADAKCWFAEGKICHGGIDPAFAMMVCLTLLIAL
Sbjct: 421 TYTVDMEMELLRFGGTPIHFPGGRPPRADAKCWFAEGKICHGGIDPAFAMMVCLTLLIAL 480
Query: 481 LSINGFAYFIRRRINKIQLIKGPNRILLTLEDVTFINPHFGSKRGSRASVSFQITSEVQS 540
LSINGFAYFIRRRINKIQLIKGPNRILLTLEDVTFINPHFGSKRGSRASVSFQITSEVQS
Sbjct: 481 LSINGFAYFIRRRINKIQLIKGPNRILLTLEDVTFINPHFGSKRGSRASVSFQITSEVQS 540
Query: 541 GRSPRLSFSSGSLTPATYENSNIAIYEGDWVWLKKFSLGDFGDLKSIKSRASDVFEMMKD 600
GRSPRLSFSSGSLTPATYENSNIAIYEGDWVWLKKFSLGDFGDLKSIKSRASDVFEMMKD
Sbjct: 541 GRSPRLSFSSGSLTPATYENSNIAIYEGDWVWLKKFSLGDFGDLKSIKSRASDVFEMMKD 600
Query: 601 LRHENINPLLGFFYDSGMFAIVTEFCSRGSLEDILTNQDVKLDWMFKSSLLLDLIKGMKY 660
LRHENINPLLGFFYDSGMFAIVTEFCSRGSLEDILTNQDVKLDWMFKSSLLLDLIKGMKY
Sbjct: 601 LRHENINPLLGFFYDSGMFAIVTEFCSRGSLEDILTNQDVKLDWMFKSSLLLDLIKGMKY 660
Query: 661 LHHREFVHGRLKSRNCVVDGRFVLKVTDYGFNDILEMLRLSEEESSMEELLWTAPELLRA 720
LHHREFVHGRLKSRNCVVDGRFVLKVTDYGFNDILEMLRLSEEESSMEELLWTAPELLRA
Sbjct: 661 LHHREFVHGRLKSRNCVVDGRFVLKVTDYGFNDILEMLRLSEEESSMEELLWTAPELLRA 720
Query: 721 PRGSRLGSFAGDVYSFAIIMQEVMVRGTPFCMMDLPAQEIINRLKKPPPVYRPVVPPEHA 780
PRGSRLGSFAGDVYSFAIIMQEVMVRGTPFCMMDLPAQEIINRLKKPPPVYRPVVPPEHA
Sbjct: 721 PRGSRLGSFAGDVYSFAIIMQEVMVRGTPFCMMDLPAQEIINRLKKPPPVYRPVVPPEHA 780
Query: 781 PPECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIR 840
PPECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIR
Sbjct: 781 PPECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIR 840
Query: 841 ERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMS 900
ERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMS
Sbjct: 841 ERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMS 900
Query: 901 EPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDI 960
EPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDI
Sbjct: 901 EPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDI 960
Query: 961 LSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPY 1020
LSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPY
Sbjct: 961 LSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPY 1020
Query: 1021 RIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWLIGKKGFMKPLPVPPPVDKDG 1080
RIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWLIGKKGFMKPLPVPPPVDKDG
Sbjct: 1021 RIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWLIGKKGFMKPLPVPPPVDKDG 1080
Query: 1081 QVGHGLQPVEIAAFQRRKAERQLVRNKP 1108
QVGHGLQPVEIAAFQRRKAERQLVRNKP
Sbjct: 1081 QVGHGLQPVEIAAFQRRKAERQLVRNKP 1108
>gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Homo
sapiens]
Length = 1103
Score = 1055 bits (2729), Expect = 0.0
Identities = 557/1084 (51%), Positives = 724/1084 (66%), Gaps = 46/1084 (4%)
Query: 38 LLSVMSLPQQVWTLPYKIGVVGPWACDSLFSKALPEVAARLAIERINRDPSFDLSYSFEY 97
LL ++ L + + +GV+GPWACD +FS+A P++AARLA R+NRDP FE
Sbjct: 39 LLLLLLLQPPALSAVFTVGVLGPWACDPIFSRARPDLAARLAAARLNRDPGLAGGPRFEV 98
Query: 98 VILNEDCQTSRALSSFISHHQMASGFIGPTNPGYCEAASLLGNSWDKGIFSWACVNYELD 157
+L E C+T +L + S SG +GP NP C A LL + W C + +
Sbjct: 99 ALLPEPCRTPGSLGAVSSALARVSGLVGPVNPAACRPAELLAEEAGIALVPWGCPWTQAE 158
Query: 158 NKISYPTFSRTLPSPIRVLVTVMKYFQWAHAGVISSDEDIWVHTANRVASALRSHGLPVG 217
T + + L +++ F WA ++++ +D+WV +++ALR+ GLPV
Sbjct: 159 G-----TTAPAVTPAADALYALLRAFGWARVALVTAPQDLWVEAGRSLSTALRARGLPVA 213
Query: 218 VVLTTGQ-DSQSMRKALQRIHQADRIRIIIMCMHSALIGGETQMHLLECAHDLKMTDGTY 276
V + D R+AL+++ R+ +IM MHS L+GGE Q +LLE A +L +TDG+
Sbjct: 214 SVTSMEPLDLSGAREALRKVRDGPRVTAVIMVMHSVLLGGEEQRYLLEAAEELGLTDGSL 273
Query: 277 VFVPYDALLYSLPYKHTPYRVLRNNPKLREAYDAVLTITVES-QEKTFYQAFTEAAARGE 335
VF+P+D + Y+L L N+ +LR A+DAVLT+T E + + A R E
Sbjct: 274 VFLPFDTIHYALSPGPEALAALANSSQLRRAHDAVLTLTRHCPSEGSVLDSLRRAQERRE 333
Query: 336 IPEKLEFDQVSPLFGTIYNSIYFIAQAMNNAMKENGQ--AGAASLVQHSRNMQFHGFNQL 393
+P L QVSPLFGTIY++++ +A+ + A G A++ +H R+ Q GF
Sbjct: 334 LPSDLNLQQVSPLFGTIYDAVFLLARGVAEARAAAGGRWVSGAAVARHIRDAQVPGFCG- 392
Query: 394 MRTDSNGNGISEYVILDTNLKEWELHSTYTVDMEMELLRFGGTPIHFP-GGRPPRADAKC 452
D G+ +V+LDT+ L +TY +D GT +HFP GG P D C
Sbjct: 393 ---DLGGDEEPPFVLLDTDAAGDRLFATYMLDPARGSFLSAGTRMHFPRGGSAPGPDPSC 449
Query: 453 WFAEGKICHGGIDPAFAMMVCLTLLIALLSINGFAYFIRRRINKIQLIKGPNRILLTLED 512
WF IC GG++P + L ++ L+ A+++R R+ +Q++ GPN+I+LT++D
Sbjct: 450 WFDPNNICGGGLEPGLVFLGFLLVVGMGLAGAFLAHYVRHRLLHMQMVSGPNKIILTVDD 509
Query: 513 VTFINPHFGSKR----GSRASVSFQITSEVQSGRSPRLSFSSGSLTPATYENSNIAIYEG 568
+TF++PH G+ R GSR+S+ + S+++SG S L ++ NI +YEG
Sbjct: 510 ITFLHPHGGTSRKVAQGSRSSLGARSMSDIRSGPSQHL------------DSPNIGVYEG 557
Query: 569 DWVWLKKFSLGDFGDLK-SIKSRASDVFEMMKDLRHENINPLLGFFYDSGM--------- 618
D VWLKKF GD +I+ F +++LRHEN+ LG F G
Sbjct: 558 DRVWLKKFP----GDQHIAIRPATKTAFSKLQELRHENVALYLGLFLARGAEGPAALWEG 613
Query: 619 -FAIVTEFCSRGSLEDILTNQDVKLDWMFKSSLLLDLIKGMKYLHHREFVHGRLKSRNCV 677
A+V+E C+RGSL+D+L +++KLDWMFKSSLLLDLIKG++YLHHR HGRLKSRNC+
Sbjct: 614 NLAVVSEHCTRGSLQDLLAQREIKLDWMFKSSLLLDLIKGIRYLHHRGVAHGRLKSRNCI 673
Query: 678 VDGRFVLKVTDYGFNDILEMLRLSEEESSMEELLWTAPELLRAPRGSRLGSFAGDVYSFA 737
VDGRFVLK+TD+G +LE ++ E E+ LWTAPELLR P R G+ AGDV+S A
Sbjct: 674 VDGRFVLKITDHGHGRLLEAQKVLPEPPRAEDQLWTAPELLRDPALERRGTLAGDVFSLA 733
Query: 738 IIMQEVMVRGTPFCMMDLPAQEIINRLKKPPPVYRPVVPPEHAPPECLQLMKQCWAEAAE 797
IIMQEV+ R P+ M++L +E++ R++ PPP+ RP+V + AP EC+ LMKQCWAE E
Sbjct: 734 IIMQEVVCRSAPYAMLELTPEEVVQRVRSPPPLCRPLVSMDQAPVECILLMKQCWAEQPE 793
Query: 798 QRPTFDEIFNQFKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLL 857
RP+ D F+ FK NKG+KTNIIDSMLRMLEQYSSNLEDLIRERTEELE+EKQKT++LL
Sbjct: 794 LRPSMDHTFDLFKNINKGRKTNIIDSMLRMLEQYSSNLEDLIRERTEELELEKQKTDRLL 853
Query: 858 TQMLPPSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFD 917
TQMLPPSVAE+LK G VEPE F+ VTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFD
Sbjct: 854 TQMLPPSVAEALKTGTPVEPEYFEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFD 913
Query: 918 AIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPV 977
AIIGSHDVYKVETIGDAYMVASGLP+RNG RHAAEIANMSLDILS+VGTF+MRHMPEVPV
Sbjct: 914 AIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPV 973
Query: 978 RIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSE 1037
RIRIGLHSGP VAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHV+LSTV IL+ L
Sbjct: 974 RIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDS 1033
Query: 1038 GYEVELRGRTELKGKGTEETFWLIGKKGFMKPLPVPPPVDKDGQVGHGLQPVEIAAFQRR 1097
GY+VELRGRTELKGKG E+TFWL+G++GF KP+P PP + + G HG+ EI +RR
Sbjct: 1034 GYQVELRGRTELKGKGAEDTFWLVGRRGFNKPIPKPPDL-QPGSSNHGISLQEIPPERRR 1092
Query: 1098 KAER 1101
K E+
Sbjct: 1093 KLEK 1096
>gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens]
Length = 1047
Score = 504 bits (1297), Expect = e-142
Identities = 348/941 (36%), Positives = 504/941 (53%), Gaps = 74/941 (7%)
Query: 162 YPTFSRTLPSPIRV---LVTVMKYFQW-AHAGVI----SSDEDIWVHTANRVASALRSHG 213
Y T RT PS ++ +VT+ +F W A A ++ +D+ T V AL+
Sbjct: 136 YRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPHYFTIEGVFEALQGSN 195
Query: 214 LPVGVVLTTGQDSQSMRKALQRIHQADRIRII---IMCMHSALIGGETQMHLLECAHDLK 270
L V + ++ +A I RI I + +H L+ + +
Sbjct: 196 LSVQHQVYA-REPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRE----------N 244
Query: 271 MTDGTYVFVPYDALLYSL---PYKHT--PYRVLRNNPK---LREAYDAVLTITVESQEKT 322
+T+G YVF D SL P + T P++ R + LREA+ VL IT
Sbjct: 245 LTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTREQAQALREAFQTVLVITYREPPNP 304
Query: 323 FYQAFTEAA---ARGEIPEKLEFDQVSPLFGTIYNSIYFIAQAMNNAMKENG-QAGAASL 378
YQ F AR + +L ++ + G Y+ I A+ +N ++E G + +
Sbjct: 305 EYQEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNETIQEGGTREDGLRI 364
Query: 379 VQHSRNMQFHGFNQLMRTDSNGNGISEYVILDT-NLKEWELHSTYTVDMEMELLRFGGTP 437
V+ + ++HG L+ D N + +++V+ +L + + + + G P
Sbjct: 365 VEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWWTGRP 424
Query: 438 IHFPGGRPPRADAKCWF-AEGKICHGGIDPAFAMMVCLT-LLIALLSINGFAYFIRRRIN 495
I + G PP + C F + C A++ T + + ++ F F
Sbjct: 425 IPWVKGAPPSDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIF-----R 479
Query: 496 KIQLIKGPNRILLTL--EDVTFINPH-FGSKRGSRASVSFQITSEVQSGRSPRLSFSSGS 552
K+ L K +L + E++ F N + GSR ++S + S GS
Sbjct: 480 KLMLEKELASMLWRIRWEELQFGNSERYHKGAGSRLTLSLR-------------GSSYGS 526
Query: 553 LTPATYEN---SNIAIYEGDWVWLKKFSLGDFGDLKSIKSRASDVFEM--MKDLRHENIN 607
L A + +N ++G+ V +K + K I+ +FE+ M+D++ ++
Sbjct: 527 LMTAHGKYQIFANTGHFKGNVVAIKHVNK------KRIELTRQVLFELKHMRDVQFNHLT 580
Query: 608 PLLGFFYDSGMFAIVTEFCSRGSLEDILTNQDVKLDWMFKSSLLLDLIKGMKYLHHREFV 667
+G D IVTE+C RGSL+DIL N + LDWMF+ SL+ DL+KGM +LH+
Sbjct: 581 RFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIIS 640
Query: 668 -HGRLKSRNCVVDGRFVLKVTDYGFNDILEMLRLSEEESSMEELLWTAPELLRAPRGSRL 726
HG LKS NCVVD RFVLK+TDYG + + + LWTAPELL
Sbjct: 641 SHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTT 700
Query: 727 GSFAGDVYSFAIIMQEVMVRGTPFCM--MDLPAQEIINRLKKPP-PVYRPVVPPEHAPPE 783
G DVYSF II+QE+ +R PF + +DL +EI+ +++ P +RP + E
Sbjct: 701 GMQKADVYSFGIILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEE 760
Query: 784 CLQLMKQCWAEAAEQRPTFDEIFNQFKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIRERT 843
+ LM++CWA+ +RP F +I + FNK T+I+D++L +EQY++NLE L+ ERT
Sbjct: 761 LVLLMERCWAQDPAERPDFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERT 820
Query: 844 EELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPI 903
+ EK+K E LL Q+LP SVAE LK+G TV+ E FD VT+YFSDIVGFT +SA S P+
Sbjct: 821 QAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPM 880
Query: 904 EVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSS 963
+VV LLNDLYT FDAII + DVYKVETIGDAYMV SGLP RNG RHA EIA M+L +L +
Sbjct: 881 QVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDA 940
Query: 964 VGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIH 1023
V +F++RH P +R+RIG+H+GPV AGVVGL MPRYCLFGDTVNTASRMES G +IH
Sbjct: 941 VSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIH 1000
Query: 1024 VSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWLIGKK 1064
VS +T L L +++ELRG E+KGKG T+WL+G++
Sbjct: 1001 VSSTTKDALDELG-CFQLELRGDVEMKGKGKMRTYWLLGER 1040
>gi|167830411 natriuretic peptide receptor 1 [Homo sapiens]
Length = 1061
Score = 504 bits (1297), Expect = e-142
Identities = 313/777 (40%), Positives = 454/777 (58%), Gaps = 39/777 (5%)
Query: 305 REAYDAVLTITVESQEKTFYQAFTEAA---ARGEIPEKLEFDQVSPLFGTIYNSIYFIAQ 361
R+A+ A IT + + Y F + A + +E V+ + + ++ + Q
Sbjct: 303 RQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQ 362
Query: 362 AMNNAMKENGQA-GAASLVQHSRNMQFHGFNQLMRTDSNGNGISEYVILDTNLKEWELHS 420
A+ + G ++ Q N F G ++ DS+G+ +++ + D + +
Sbjct: 363 AVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRV 422
Query: 421 TYTVD-MEMELLRFGGTPIHFPGGRPPRADAKCWFAEGKICHGGIDPAFAMMVCLTLLIA 479
+ EL+ G +++P G PP KC F + ++ L ++
Sbjct: 423 VLNYNGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGSLS 482
Query: 480 LLSINGFAYFIRRRINKIQLIKGPNRILLTL--EDV--TFINPHFGSKRGSRASVSFQIT 535
LL I ++FI R K+QL K L + EDV + + H S GSR ++S
Sbjct: 483 LLGILIVSFFIYR---KMQLEKELASELWRVRWEDVEPSSLERHLRSA-GSRLTLS---- 534
Query: 536 SEVQSGRSPRLSFSSGSLTPATYEN-SNIAIYEGDWVWLKKFSLGDFGDLKSIKSRASDV 594
GR ++ S T ++ + A Y+G+ V +K+ + K I+ +
Sbjct: 535 -----GRGS--NYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVNR------KRIELTRKVL 581
Query: 595 FEM--MKDLRHENINPLLGFFYDSGMFAIVTEFCSRGSLEDILTNQDVKLDWMFKSSLLL 652
FE+ M+D+++E++ +G D I+TE+C RGSL+DIL N+ + LDWMF+ SL
Sbjct: 582 FELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTN 641
Query: 653 DLIKGMKYLHHREFV-HGRLKSRNCVVDGRFVLKVTDYGFNDILEMLRLSEEESSMEELL 711
D++KGM +LH+ HG LKS NCVVDGRFVLK+TDYG + L + + + L
Sbjct: 642 DIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRD-LDPEQGHTVYAKKL 700
Query: 712 WTAPELLRAPRGSRLGSFAGDVYSFAIIMQEVMVRGTPFCM--MDLPAQEIINRLKK-PP 768
WTAPELLR GS AGDVYSF II+QE+ +R F + +DL +EII R+ +
Sbjct: 701 WTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFHVEGLDLSPKEIIERVTRGEQ 760
Query: 769 PVYRPVVPPEHAPPECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNKGKKTNIIDSMLRML 828
P +RP + + E LM++CWAE ++RP F +I + FN+ +NI+D++L +
Sbjct: 761 PPFRPSLALQSHLEELGLLMQRCWAEDPQERPPFQQIRLTLRKFNRENSSNILDNLLSRM 820
Query: 829 EQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYFS 888
EQY++NLE+L+ ERT+ EK+K E LL Q+LP SVAE LK+G TV+ E FD VT+YFS
Sbjct: 821 EQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFS 880
Query: 889 DIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSR 948
DIVGFT +SA S P++VV LLNDLYT FDA+I + DVYKVETIGDAYMV SGLP RNG
Sbjct: 881 DIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRL 940
Query: 949 HAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVN 1008
HA E+A M+L +L +V +F++RH P+ +R+RIG+H+GPV AGVVGL MPRYCLFGDTVN
Sbjct: 941 HACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVN 1000
Query: 1009 TASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWLIGKKG 1065
TASRMES G +IH+S T +L+ G+E+ELRG E+KGKG T+WL+G++G
Sbjct: 1001 TASRMESNGEALKIHLSSETKAVLEEFG-GFELELRGDVEMKGKGKVRTYWLLGERG 1056
>gi|222080083 guanylate cyclase 2C [Homo sapiens]
Length = 1073
Score = 426 bits (1094), Expect = e-119
Identities = 249/541 (46%), Positives = 336/541 (62%), Gaps = 53/541 (9%)
Query: 597 MMKDLRHEN----------INPLLGFFY------------DSGMFAIVTEFCSRGSLEDI 634
++KDL+H + +N LL Y D+ +F ++ E+C RGSL ++
Sbjct: 514 ILKDLKHNDGNFTEKQKIELNKLLQIDYYNLTKFYGTVKLDTMIFGVI-EYCERGSLREV 572
Query: 635 LTN-----QDVKLDWMFKSSLLLDLIKGMKYLHHREF-VHGRLKSRNCVVDGRFVLKVTD 688
L + +DW FK S+L D+ KGM YLH + VHGRLKS NCVVD R V+K+TD
Sbjct: 573 LNDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITD 632
Query: 689 YGFNDILEMLRLSEEESSMEELLWTAPELLRAPRGSRLGSFAGDVYSFAIIMQEVMVRGT 748
+G N IL ++ LWTAPE LR S+ GDVYS+ II QE+++R
Sbjct: 633 FGCNSILPP----------KKDLWTAPEHLRQANISQ----KGDVYSYGIIAQEIILRKE 678
Query: 749 PFCMMDL-PAQEIINRLKKPPPV--YRPVVPPEHAPPECLQ---LMKQCWAEAAEQRPTF 802
F + E I R++ + +RP + E A + L+ L+K CW E E+RP F
Sbjct: 679 TFYTLSCRDRNEKIFRVENSNGMKPFRPDLFLETAEEKELEVYLLVKNCWEEDPEKRPDF 738
Query: 803 DEIFNQ----FKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLT 858
+I F F+ K + +D+++R L+ YS NLE L+ ERT+ + E+ + ++L
Sbjct: 739 KKIETTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNF 798
Query: 859 QMLPPSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDA 918
+LP V +SLK+ VEPE ++ VT+YFSDIVGFTTI S P+EVVD+LND+Y FD
Sbjct: 799 MLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDH 858
Query: 919 IIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVR 978
I+ HDVYKVETIGDAYMVASGLPKRNG+RHA +IA M+L+ILS +GTF++ H+P +P+
Sbjct: 859 IVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIW 918
Query: 979 IRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEG 1038
IRIG+HSGP AGVVG+ MPRYCLFGDTVNTASRMESTGLP RIHVS ST+ IL+
Sbjct: 919 IRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQ 978
Query: 1039 YEVELRGRTELKGKGTEETFWLIGKKGFMKPLPVPPPVDKDGQVGHGLQPVEIAAFQRRK 1098
+ E+RG T LKG+G E T+WL G K LP PP V+ ++ + + Q+R+
Sbjct: 979 FLYEVRGETYLKGRGNETTYWLTGMKDQKFNLPTPPTVENQQRLQAEFSDMIANSLQKRQ 1038
Query: 1099 A 1099
A
Sbjct: 1039 A 1039
>gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Homo
sapiens]
Length = 455
Score = 171 bits (434), Expect = 3e-42
Identities = 102/235 (43%), Positives = 143/235 (60%), Gaps = 8/235 (3%)
Query: 815 GKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCT 874
G++ D + + L + + LE + + LE EK+KT LL + P VA+ L +G
Sbjct: 181 GEQARAQDGLKKRLGKLKATLE----QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQV 236
Query: 875 VEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDA 934
V+ + F VT+ FSDIVGFT I + P++V+ +LN LYT FD G DVYKVETIGDA
Sbjct: 237 VQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA 296
Query: 935 YMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVG 994
Y VA GL K + + HA +IA M+L ++ H P+++RIGLHSG V AGVVG
Sbjct: 297 YCVAGGLHKESDT-HAVQIALMALKMMELSDEVMSPH--GEPIKMRIGLHSGSVFAGVVG 353
Query: 995 LTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTEL 1049
+ MPRYCLFG+ V A++ ES +P +I+VS +T +L++ G+ R R EL
Sbjct: 354 VKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKD-CPGFVFTPRSREEL 407
>gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 171 bits (434), Expect = 3e-42
Identities = 102/235 (43%), Positives = 143/235 (60%), Gaps = 8/235 (3%)
Query: 815 GKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCT 874
G++ D + + L + + LE + + LE EK+KT LL + P VA+ L +G
Sbjct: 416 GEQARAQDGLKKRLGKLKATLE----QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQV 471
Query: 875 VEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDA 934
V+ + F VT+ FSDIVGFT I + P++V+ +LN LYT FD G DVYKVETIGDA
Sbjct: 472 VQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA 531
Query: 935 YMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVG 994
Y VA GL K + + HA +IA M+L ++ H P+++RIGLHSG V AGVVG
Sbjct: 532 YCVAGGLHKESDT-HAVQIALMALKMMELSDEVMSPH--GEPIKMRIGLHSGSVFAGVVG 588
Query: 995 LTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTEL 1049
+ MPRYCLFG+ V A++ ES +P +I+VS +T +L++ G+ R R EL
Sbjct: 589 VKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKD-CPGFVFTPRSREEL 642
>gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 171 bits (434), Expect = 3e-42
Identities = 102/235 (43%), Positives = 143/235 (60%), Gaps = 8/235 (3%)
Query: 815 GKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCT 874
G++ D + + L + + LE + + LE EK+KT LL + P VA+ L +G
Sbjct: 416 GEQARAQDGLKKRLGKLKATLE----QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQV 471
Query: 875 VEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDA 934
V+ + F VT+ FSDIVGFT I + P++V+ +LN LYT FD G DVYKVETIGDA
Sbjct: 472 VQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA 531
Query: 935 YMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVG 994
Y VA GL K + + HA +IA M+L ++ H P+++RIGLHSG V AGVVG
Sbjct: 532 YCVAGGLHKESDT-HAVQIALMALKMMELSDEVMSPH--GEPIKMRIGLHSGSVFAGVVG 588
Query: 995 LTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTEL 1049
+ MPRYCLFG+ V A++ ES +P +I+VS +T +L++ G+ R R EL
Sbjct: 589 VKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKD-CPGFVFTPRSREEL 642
>gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 171 bits (434), Expect = 3e-42
Identities = 102/235 (43%), Positives = 143/235 (60%), Gaps = 8/235 (3%)
Query: 815 GKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCT 874
G++ D + + L + + LE + + LE EK+KT LL + P VA+ L +G
Sbjct: 416 GEQARAQDGLKKRLGKLKATLE----QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQV 471
Query: 875 VEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDA 934
V+ + F VT+ FSDIVGFT I + P++V+ +LN LYT FD G DVYKVETIGDA
Sbjct: 472 VQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA 531
Query: 935 YMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVG 994
Y VA GL K + + HA +IA M+L ++ H P+++RIGLHSG V AGVVG
Sbjct: 532 YCVAGGLHKESDT-HAVQIALMALKMMELSDEVMSPH--GEPIKMRIGLHSGSVFAGVVG 588
Query: 995 LTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTEL 1049
+ MPRYCLFG+ V A++ ES +P +I+VS +T +L++ G+ R R EL
Sbjct: 589 VKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKD-CPGFVFTPRSREEL 642
>gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 171 bits (434), Expect = 3e-42
Identities = 102/235 (43%), Positives = 143/235 (60%), Gaps = 8/235 (3%)
Query: 815 GKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCT 874
G++ D + + L + + LE + + LE EK+KT LL + P VA+ L +G
Sbjct: 416 GEQARAQDGLKKRLGKLKATLE----QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQV 471
Query: 875 VEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDA 934
V+ + F VT+ FSDIVGFT I + P++V+ +LN LYT FD G DVYKVETIGDA
Sbjct: 472 VQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA 531
Query: 935 YMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVG 994
Y VA GL K + + HA +IA M+L ++ H P+++RIGLHSG V AGVVG
Sbjct: 532 YCVAGGLHKESDT-HAVQIALMALKMMELSDEVMSPH--GEPIKMRIGLHSGSVFAGVVG 588
Query: 995 LTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTEL 1049
+ MPRYCLFG+ V A++ ES +P +I+VS +T +L++ G+ R R EL
Sbjct: 589 VKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKD-CPGFVFTPRSREEL 642
>gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens]
Length = 732
Score = 167 bits (424), Expect = 4e-41
Identities = 104/236 (44%), Positives = 145/236 (61%), Gaps = 10/236 (4%)
Query: 815 GKKTNIIDSMLRMLEQYSSNLEDLIRERTEE-LEIEKQKTEKLLTQMLPPSVAESLKKGC 873
G++ D + + +++ + LE RT + LE EK+KT LL + P VA+ L +G
Sbjct: 456 GEQAKAQDGLKKRMDKLKATLE-----RTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQ 510
Query: 874 TVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGD 933
V+ FD VT+ FSDIVGFT I A P++V+ +LN+LYT FD G D+YKVETIGD
Sbjct: 511 QVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGD 570
Query: 934 AYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVV 993
AY VA+GL R HA IA M+L ++ + ++ P+++RIG+HSG V+AGVV
Sbjct: 571 AYCVAAGL-HRKSLCHAKPIALMALKMMEL--SEEVLTPDGRPIQMRIGIHSGSVLAGVV 627
Query: 994 GLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTEL 1049
G+ MPRYCLFG+ V AS+ ES P RI+VS +T +L+ E + R R EL
Sbjct: 628 GVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKR-EESFTFIPRSREEL 682
>gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Homo
sapiens]
Length = 624
Score = 167 bits (422), Expect = 7e-41
Identities = 96/214 (44%), Positives = 133/214 (62%), Gaps = 7/214 (3%)
Query: 815 GKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCT 874
G++ D + + L + + LE + + LE EK+KT LL + P VA+ L +G
Sbjct: 416 GEQARAQDGLKKRLGKLKATLE----QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQV 471
Query: 875 VEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDA 934
V+ + F VT+ FSDIVGFT I + P++V+ +LN LYT FD G DVYKVETIGDA
Sbjct: 472 VQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA 531
Query: 935 YMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVG 994
Y VA GL K + + HA +IA M+L ++ H P+++RIGLHSG V AGVVG
Sbjct: 532 YCVAGGLHKESDT-HAVQIALMALKMMELSDEVMSPH--GEPIKMRIGLHSGSVFAGVVG 588
Query: 995 LTMPRYCLFGDTVNTASRMESTGLPYRIHVSLST 1028
+ MPRYCLFG+ V A++ ES +P +I+VS +T
Sbjct: 589 VKMPRYCLFGNNVTLANKFESCSVPRKINVSPTT 622
>gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens]
Length = 619
Score = 160 bits (406), Expect = 5e-39
Identities = 101/247 (40%), Positives = 139/247 (56%), Gaps = 14/247 (5%)
Query: 828 LEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYF 887
L Q L D ++ LE EK+KT+ LL +LPPSVA L+ V + +D VT+ F
Sbjct: 365 LTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNVTILF 424
Query: 888 SDIVGFTTISAMSEP----IEVVDLLNDLYTLFDAIIGSHD---VYKVETIGDAYMVASG 940
S IVGF + +++V+LLNDLYT FD + S VYKVET+GD YM SG
Sbjct: 425 SGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSG 484
Query: 941 LPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRY 1000
LP+ HA I +++LD++ G ++ V+I IG+H+G VV GV+G MPRY
Sbjct: 485 LPEPC-IHHARSICHLALDMMEIAGQVQV---DGESVQITIGIHTGEVVTGVIGQRMPRY 540
Query: 1001 CLFGDTVNTASRMESTGLPYRIHVSLSTVTIL---QNLSEGYEVELRGRTELKGKGTEET 1057
CLFG+TVN SR E+TG +I+VS T L +N + +E RG +KGK
Sbjct: 541 CLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQ 600
Query: 1058 FWLIGKK 1064
W + +K
Sbjct: 601 VWFLSRK 607
>gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens]
Length = 1168
Score = 118 bits (296), Expect = 3e-26
Identities = 79/237 (33%), Positives = 131/237 (55%), Gaps = 25/237 (10%)
Query: 844 EELEIEKQKTEKLLTQMLPPSVAESL----KKGCTVEPEGFDLVTLYFSDIVGFTT---- 895
EE+E + +LL +LP VA ++ + + + V + F+ I F+
Sbjct: 935 EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVE 994
Query: 896 ISAMSEPIEVVDLLNDLYTLFDAIIGSH---DVYKVETIGDAYMVASGLPKRN----GSR 948
+ A +E +E + LLN++ FD II + K++TIG YM ASGL G
Sbjct: 995 LEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRS 1054
Query: 949 HAAEIANMSLDILSSVGTFKMRHMPEVPV---RIRIGLHSGPVVAGVVGLTMPRYCLFGD 1005
H +A+ ++ ++ +M+H+ E +++IGL+ GPVVAGV+G P+Y ++G+
Sbjct: 1055 HITALADYAMRLME-----QMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGN 1109
Query: 1006 TVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWLIG 1062
TVN +SRM+STG+P RI V+ +L ++GY++E RG ++KGKG T++L G
Sbjct: 1110 TVNVSSRMDSTGVPDRIQVTTDLYQVL--AAKGYQLECRGVVKVKGKGEMTTYFLNG 1164
Score = 107 bits (266), Expect = 8e-23
Identities = 70/225 (31%), Positives = 119/225 (52%), Gaps = 23/225 (10%)
Query: 846 LEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGF----------DLVTLYFSDIVGFTT 895
L+ E ++ E+LL +LP VA +K+ + E D V++ F+DI GFT+
Sbjct: 331 LQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTS 390
Query: 896 ISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIAN 955
+++ E+V LN+L+ FD + + +++ +GD Y SGLP+ HA
Sbjct: 391 LASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARAD-HAHCCVE 449
Query: 956 MSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMES 1015
M +D++ ++ +R + V V +R+G+HSG V GV+GL ++ ++ + V A+ ME+
Sbjct: 450 MGVDMIEAISL--VREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEA 507
Query: 1016 TGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWL 1060
G RIH++ +T LQ L+ YEVE G+G E +L
Sbjct: 508 GGRAGRIHITRAT---LQYLNGDYEVE-------PGRGGERNAYL 542
>gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens]
Length = 1115
Score = 118 bits (296), Expect = 3e-26
Identities = 79/237 (33%), Positives = 131/237 (55%), Gaps = 25/237 (10%)
Query: 844 EELEIEKQKTEKLLTQMLPPSVAESL----KKGCTVEPEGFDLVTLYFSDIVGFTT---- 895
EE+E + +LL +LP VA ++ + + + V + F+ I F+
Sbjct: 882 EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVE 941
Query: 896 ISAMSEPIEVVDLLNDLYTLFDAIIGSH---DVYKVETIGDAYMVASGLPKRN----GSR 948
+ A +E +E + LLN++ FD II + K++TIG YM ASGL G
Sbjct: 942 LEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRS 1001
Query: 949 HAAEIANMSLDILSSVGTFKMRHMPEVPV---RIRIGLHSGPVVAGVVGLTMPRYCLFGD 1005
H +A+ ++ ++ +M+H+ E +++IGL+ GPVVAGV+G P+Y ++G+
Sbjct: 1002 HITALADYAMRLME-----QMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGN 1056
Query: 1006 TVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWLIG 1062
TVN +SRM+STG+P RI V+ +L ++GY++E RG ++KGKG T++L G
Sbjct: 1057 TVNVSSRMDSTGVPDRIQVTTDLYQVL--AAKGYQLECRGVVKVKGKGEMTTYFLNG 1111
Score = 107 bits (266), Expect = 8e-23
Identities = 70/225 (31%), Positives = 119/225 (52%), Gaps = 23/225 (10%)
Query: 846 LEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGF----------DLVTLYFSDIVGFTT 895
L+ E ++ E+LL +LP VA +K+ + E D V++ F+DI GFT+
Sbjct: 331 LQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTS 390
Query: 896 ISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIAN 955
+++ E+V LN+L+ FD + + +++ +GD Y SGLP+ HA
Sbjct: 391 LASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARAD-HAHCCVE 449
Query: 956 MSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMES 1015
M +D++ ++ +R + V V +R+G+HSG V GV+GL ++ ++ + V A+ ME+
Sbjct: 450 MGVDMIEAISL--VREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEA 507
Query: 1016 TGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWL 1060
G RIH++ +T LQ L+ YEVE G+G E +L
Sbjct: 508 GGRAGRIHITRAT---LQYLNGDYEVE-------PGRGGERNAYL 542
>gi|4557257 adenylate cyclase 8 [Homo sapiens]
Length = 1251
Score = 115 bits (288), Expect = 2e-25
Identities = 92/298 (30%), Positives = 151/298 (50%), Gaps = 34/298 (11%)
Query: 830 QYSSNLEDLIR----ERTEELEIEKQKTEKLLTQMLPPSVA----ESLKKGCTVEPEGFD 881
+Y++ L+ L R E E++ ++ E +L +LP VA E + + + +D
Sbjct: 920 EYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYD 979
Query: 882 LVTLYFSDIVGFTTISAMSEP----IEVVDLLNDLYTLFDAIIGS---HDVYKVETIGDA 934
V + F+ I GF + +E +E + LLN++ FD ++G D+ K++TIG
Sbjct: 980 AVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGST 1039
Query: 935 YMVASGL-PKRNGSR----HAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVV 989
YM SGL P++ H +A+ SL + S+ +RIG+ G VV
Sbjct: 1040 YMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNF--ELRIGISHGSVV 1097
Query: 990 AGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTEL 1049
AGV+G P+Y ++G TVN ASRM+STG+ RI V T IL++ +G+ + RG +
Sbjct: 1098 AGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKD--QGFAFDYRGEIYV 1155
Query: 1050 KG----KGTEETFWLIGKKGFMKPLP-VPPPVDKDGQVGHGLQPVEIAAFQRRKAERQ 1102
KG +G +T++L+G+ ++P P + PP GQ + L V + Q +RQ
Sbjct: 1156 KGISEQEGKIKTYFLLGR---VQPNPFILPPRRLPGQ--YSLAAVVLGLVQSLNRQRQ 1208
Score = 107 bits (268), Expect = 5e-23
Identities = 75/242 (30%), Positives = 125/242 (51%), Gaps = 22/242 (9%)
Query: 846 LEIEKQKTEKLLTQMLPPSVA-ESLKKGCTVEPEG------------FDLVTLYFSDIVG 892
LE E Q+ E+L+ +LP V E + VE E ++ V++ F+D+ G
Sbjct: 363 LETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKG 422
Query: 893 FTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAE 952
FT +S E+V +LN+L+ FD + H +++ +GD Y SGLP+ HA
Sbjct: 423 FTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPR-QDHAHC 481
Query: 953 IANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASR 1012
M L ++ ++ + R +V +RIG+HSG V+ GV+GL ++ ++ V+ A++
Sbjct: 482 CVEMGLSMIKTIRYVRSRTKHDVD--MRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANK 539
Query: 1013 MESTGLPYRIHVSLSTVTILQ---NLSEGYEVELRGRTELKGKGTEETFWLIGKKGFMKP 1069
+ES G+P RIH+S +T+ L N+ EG+ E R E K ET+ + + +
Sbjct: 540 LESGGIPGRIHISKATLDCLNGDYNVEEGHGKE---RNEFLRKHNIETYLIKQPEDSLLS 596
Query: 1070 LP 1071
LP
Sbjct: 597 LP 598
>gi|34486092 adenylate cyclase 5 [Homo sapiens]
Length = 1261
Score = 115 bits (288), Expect = 2e-25
Identities = 79/240 (32%), Positives = 130/240 (54%), Gaps = 25/240 (10%)
Query: 841 ERTEELEIEKQKTEKLLTQMLPPSVAESL----KKGCTVEPEGFDLVTLYFSDIVGFTT- 895
E EE+E + +LL +LP VA ++ + + + V + F+ I F+
Sbjct: 1024 EEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEF 1083
Query: 896 ---ISAMSEPIEVVDLLNDLYTLFDAIIGS---HDVYKVETIGDAYMVASGLPKRN---- 945
+ A +E +E + LLN++ FD II + K++TIG YM ASGL
Sbjct: 1084 YVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKV 1143
Query: 946 GSRHAAEIANMSLDILSSVGTFKMRHMPEVPV---RIRIGLHSGPVVAGVVGLTMPRYCL 1002
G H +A+ ++ ++ +M+++ E +++IGL+ GPVVAGV+G P+Y +
Sbjct: 1144 GKTHIKALADFAMKLMD-----QMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDI 1198
Query: 1003 FGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWLIG 1062
+G+TVN ASRM+STG+P RI V+ +L + Y++E RG ++KGKG T++L G
Sbjct: 1199 WGNTVNVASRMDSTGVPDRIQVTTDMYQVL--AANTYQLECRGVVKVKGKGEMMTYFLNG 1256
Score = 103 bits (258), Expect = 7e-22
Identities = 65/204 (31%), Positives = 109/204 (53%), Gaps = 16/204 (7%)
Query: 849 EKQKTEKLLTQMLPPSVAESLKKGCTVEPEGF----------DLVTLYFSDIVGFTTISA 898
E Q+ E+LL +LP VA +K + E D V++ F+DI GFT++++
Sbjct: 424 ENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLAS 483
Query: 899 MSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSL 958
E+V LN+L+ FD + + +++ +GD Y SGLP+ HA M +
Sbjct: 484 QCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARAD-HAHCCVEMGM 542
Query: 959 DILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGL 1018
D++ ++ +R + V V +R+G+HSG V GV+GL ++ ++ + V A+ ME+ G
Sbjct: 543 DMIEAISL--VREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGK 600
Query: 1019 PYRIHVSLSTVTILQNLSEGYEVE 1042
RIH++ +T L L+ YEVE
Sbjct: 601 AGRIHITKAT---LNYLNGDYEVE 621
>gi|31083193 adenylate cyclase 1 [Homo sapiens]
Length = 1119
Score = 115 bits (287), Expect = 3e-25
Identities = 76/222 (34%), Positives = 123/222 (55%), Gaps = 20/222 (9%)
Query: 830 QYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGF--------- 880
Q S +ED +R LE E +K E+LL +LP +VA +K+ PE
Sbjct: 245 QARSCIEDRLR-----LEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRH 299
Query: 881 DLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASG 940
D V++ F+DIVGFT +++ E+V LLN+L+ FD + + +++ +GD Y SG
Sbjct: 300 DNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSG 359
Query: 941 LPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRY 1000
L + + HA M LD++ ++ + + EV + +R+GLH+G V+ GV+GL +Y
Sbjct: 360 LTQPK-TDHAHCCVEMGLDMIDTITS--VAEATEVDLNMRVGLHTGRVLCGVLGLRKWQY 416
Query: 1001 CLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVE 1042
++ + V A+ ME+ GLP ++H+ T T L L+ YEVE
Sbjct: 417 DVWSNDVTLANVMEAAGLPGKVHI---TKTTLACLNGDYEVE 455
Score = 105 bits (262), Expect = 2e-22
Identities = 74/261 (28%), Positives = 134/261 (51%), Gaps = 26/261 (9%)
Query: 821 IDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAE----SLKKGCTVE 876
+D LR+ +++ E E E++E K ++L +LP VA+ S + +
Sbjct: 805 VDIRLRLDYLWAAQAE----EEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLY 860
Query: 877 PEGFDLVTLYFSDIVGFTT----ISAMSEPIEVVDLLNDLYTLFDAIIGSH---DVYKVE 929
+ + V + F+ I F + + +E + LLN++ FD ++ D+ K++
Sbjct: 861 YQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIK 920
Query: 930 TIGDAYMVASGLPKRNGSR-------HAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIG 982
TIG YM A GL +G++ H + +A+ ++++ + + + +R+G
Sbjct: 921 TIGSTYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFDVLDEINYQSYNDFV--LRVG 978
Query: 983 LHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVE 1042
++ GPVVAGV+G P+Y ++G+TVN ASRM+STG+ RI V+ +L+ Y
Sbjct: 979 INVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCP--YHFV 1036
Query: 1043 LRGRTELKGKGTEETFWLIGK 1063
RG+ +KGKG T++L G+
Sbjct: 1037 CRGKVSVKGKGEMLTYFLEGR 1057
>gi|4557255 adenylate cyclase 7 [Homo sapiens]
Length = 1080
Score = 113 bits (283), Expect = 9e-25
Identities = 69/217 (31%), Positives = 122/217 (56%), Gaps = 25/217 (11%)
Query: 845 ELEIEKQKTEKLLTQMLPPSVAESLK------------KGCTVEPEGFDL-------VTL 885
+L IEK++ E LL +LP ++ +K + C + L V++
Sbjct: 221 KLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSI 280
Query: 886 YFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRN 945
++DIVGFT +++ P E+V +LN+L+ FD I +++ +++ +GD Y SGLP
Sbjct: 281 LYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSL 340
Query: 946 GSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGD 1005
+ HA M LD+ ++ ++R V + +R+G+HSG V+ GV+GL +Y ++
Sbjct: 341 PT-HARNCVKMGLDMCQAIK--QVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSH 397
Query: 1006 TVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVE 1042
V+ A+RME+ G+P R+H++ +T L++L + YEVE
Sbjct: 398 DVSLANRMEAAGVPGRVHITEAT---LKHLDKAYEVE 431
Score = 110 bits (275), Expect = 7e-24
Identities = 78/240 (32%), Positives = 119/240 (49%), Gaps = 23/240 (9%)
Query: 840 RERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEP---EGFDLVTLYFSDI----VG 892
++ EE E + LL +LP VA E + +D V + F+ + V
Sbjct: 832 KKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPDFKVF 891
Query: 893 FTTISAMSEPIEVVDLLNDLYTLFDAIIGS---HDVYKVETIGDAYMVASGLPKRNGSR- 948
+T E +E + LLN++ FD ++ V K++TIG YM A+GL +G
Sbjct: 892 YTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHEN 951
Query: 949 --------HAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRY 1000
H + S+ ++S + R+R+G++ GPV+AGV+G P+Y
Sbjct: 952 QELERQHAHIGVMVEFSIALMSKLDGINRHSFNSF--RLRVGINHGPVIAGVIGARKPQY 1009
Query: 1001 CLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWL 1060
++G+TVN ASRMESTG +I V+ T TILQ L GY E RG +KGKG T+++
Sbjct: 1010 DIWGNTVNVASRMESTGELGKIQVTEETCTILQGL--GYSCECRGLINVKGKGELRTYFV 1067
>gi|115387102 adenylate cyclase 2 [Homo sapiens]
Length = 1091
Score = 113 bits (282), Expect = 1e-24
Identities = 78/261 (29%), Positives = 138/261 (52%), Gaps = 31/261 (11%)
Query: 828 LEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEG-------- 879
L+Q + + I+ R + LE EK++ E+LL +LP +A +K +G
Sbjct: 216 LQQTYQDTCNCIKSRIK-LEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMEN 274
Query: 880 -----------FDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKV 928
V++ ++DIVGFT +++ P E+V +LN+L+ FD I ++ ++
Sbjct: 275 TNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRI 334
Query: 929 ETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPV 988
+ +GD Y SGLP + HA M LD+ ++ K+R V + +R+G+HSG V
Sbjct: 335 KILGDCYYCVSGLP-ISLPNHAKNCVKMGLDMCEAIK--KVRDATGVDINMRVGVHSGNV 391
Query: 989 VAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTE 1048
+ GV+GL +Y ++ V A+ ME+ G+P R+H+S T L++L+ Y+VE G +
Sbjct: 392 LCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVT---LEHLNGAYKVE-EGDGD 447
Query: 1049 LKGKGTEE----TFWLIGKKG 1065
++ ++ T+++I KG
Sbjct: 448 IRDPYLKQHLVKTYFVINPKG 468
Score = 107 bits (266), Expect = 8e-23
Identities = 77/240 (32%), Positives = 120/240 (50%), Gaps = 21/240 (8%)
Query: 840 RERTEELEIEKQKTEKLLTQMLPPSVAESLK----KGCTVEPEGFDLVTLYFSDIVGF-- 893
++ EE+E + LL +LP VAE K + + +D V + F+ I F
Sbjct: 839 KKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKE 898
Query: 894 --TTISAMSEPIEVVDLLNDLYTLFDAIIGS---HDVYKVETIGDAYMVASGLPKRNGSR 948
T E +E + LLN++ FD ++ V K++TIG YM A+GL
Sbjct: 899 FYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQE 958
Query: 949 HAAE-------IANMSLDILSSVGTFKMRHMPEV-PVRIRIGLHSGPVVAGVVGLTMPRY 1000
H+ E I M + VG + ++R+G++ GPV+AGV+G P+Y
Sbjct: 959 HSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQY 1018
Query: 1001 CLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWL 1060
++G+TVN ASRM+STG+ +I V+ T +LQ L GY RG +KGKG +T+++
Sbjct: 1019 DIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTL--GYTCTCRGIINVKGKGDLKTYFV 1076
>gi|24497587 adenylate cyclase 4 [Homo sapiens]
Length = 1077
Score = 110 bits (276), Expect = 6e-24
Identities = 81/242 (33%), Positives = 128/242 (52%), Gaps = 23/242 (9%)
Query: 839 IRERTEELEIEKQKTEKLLTQMLPPSVAESL----KKGCTVEPEGFDLVTLYFSDIVGFT 894
+R+ EE E + T LL +LP VA ++ + + ++ V + F+ + F
Sbjct: 824 LRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFK 883
Query: 895 TISAMS----EPIEVVDLLNDLYTLFDAIIGS---HDVYKVETIGDAYMVASGLPKRNGS 947
+ S E +E + LLN++ FD ++ V K++TIG YM A+GL +G
Sbjct: 884 EFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSG- 942
Query: 948 RHAAEIANMSLDILSSVGTFKMRHMPEVPV---------RIRIGLHSGPVVAGVVGLTMP 998
+ A + A S L ++ F + ++ V R+R+GL+ GPVVAGV+G P
Sbjct: 943 QDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKP 1002
Query: 999 RYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETF 1058
+Y ++G+TVN ASRMESTG+ +I V+ T LQ+L GY RG ++KGKG T+
Sbjct: 1003 QYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSL--GYTCYSRGVIKVKGKGQLCTY 1060
Query: 1059 WL 1060
+L
Sbjct: 1061 FL 1062
Score = 107 bits (266), Expect = 8e-23
Identities = 70/219 (31%), Positives = 116/219 (52%), Gaps = 25/219 (11%)
Query: 846 LEIEKQKTEKLLTQMLPPSVAESLKK--------GCTVEPEGFDL-----------VTLY 886
L+ EK+ E LL +LP +A +K G PE + V++
Sbjct: 216 LDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVL 275
Query: 887 FSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNG 946
++DIVGFT +++ P E+V +LN+L+ FD I H+ +++ +GD Y SGLP +
Sbjct: 276 YADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLP-LSL 334
Query: 947 SRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDT 1006
HA M LD+ ++ K+R V + +R+G+HSG V+ GV+GL +Y ++
Sbjct: 335 PDHAINCVRMGLDMCRAIR--KLRAATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHD 392
Query: 1007 VNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRG 1045
V A+ ME+ G+P R+H++ +T+ + L+ Y VE G
Sbjct: 393 VTLANHMEAGGVPGRVHITGATLAL---LAGAYAVEDAG 428
>gi|57242761 receptor (TNFRSF)-interacting serine-threonine kinase 1
[Homo sapiens]
Length = 671
Score = 105 bits (263), Expect = 2e-22
Identities = 76/268 (28%), Positives = 131/268 (48%), Gaps = 22/268 (8%)
Query: 596 EMMKDLRHENINPLLGFFYDSGMFAIVTEFCSRGSLEDILTNQDVKLDWMFKSSLLLDLI 655
+MM LRH + LLG + G +++V E+ +G+L +L ++ K ++L++I
Sbjct: 65 KMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVL-KAEMSTPLSVKGRIILEII 123
Query: 656 KGMKYLHHREFVHGRLKSRNCVVDGRFVLKVTDYGFNDILEMLRL-SEEESSMEE----- 709
+GM YLH + +H LK N +VD F +K+ D G +L +EE + + E
Sbjct: 124 EGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTA 183
Query: 710 ------LLWTAPELLRAPRGSRLGSFAGDVYSFAIIMQEVMVRGTPFCMMDLPAQEIINR 763
L + APE L + DVYSFA+++ + P+ + Q++I
Sbjct: 184 KKNGGTLYYMAPEHLNDVNAK--PTEKSDVYSFAVVLWAIFANKEPY-ENAICEQQLIMC 240
Query: 764 LKKPPPVYRPVVP--PEHAPPECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNKGKKTNII 821
+K RP V E+ P E + LMK CW E RPTF I +F+ F + +
Sbjct: 241 IKSG---NRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESV 297
Query: 822 DSMLRMLEQYSSNLEDLIRERTEELEIE 849
+ ++ L++ SN E+ + +R + L+++
Sbjct: 298 EEDVKSLKKEYSN-ENAVVKRMQSLQLD 324
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 103 bits (257), Expect = 9e-22
Identities = 77/259 (29%), Positives = 127/259 (49%), Gaps = 26/259 (10%)
Query: 571 VWLKKFSLGDFGDLKSIK--SRASDVF----EMMKDLRHENINPLLGFFYDSGMFAIVTE 624
VW+ ++ +KS+K S + D F +MK L+H+ + L ++ I+TE
Sbjct: 259 VWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIY-IITE 317
Query: 625 FCSRGSLEDIL-TNQDVKLDWMFKSSLLLDLIKGMKYLHHREFVHGRLKSRNCVVDGRFV 683
+ GSL D L T +KL + + +GM ++ R ++H L++ N +V
Sbjct: 318 YMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLS 377
Query: 684 LKVTDYGFNDILEMLRLSEEESSMEELLWTAPELLRAPRGSRLGSFA--GDVYSFAIIMQ 741
K+ D+G ++E + E + + WTAPE + G+F DV+SF I++
Sbjct: 378 CKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAI------NYGTFTIKSDVWSFGILLT 431
Query: 742 EVMVRG-TPFCMMDLPAQEIINRLKKPPPVYRPVVPPEHAPPECLQLMKQCWAEAAEQRP 800
E++ G P+ M P E+I L++ YR +V P++ P E QLM+ CW E E RP
Sbjct: 432 EIVTHGRIPYPGMTNP--EVIQNLERG---YR-MVRPDNCPEELYQLMRLCWKERPEDRP 485
Query: 801 TFD---EIFNQFKTFNKGK 816
TFD + F T +G+
Sbjct: 486 TFDYLRSVLEDFFTATEGQ 504
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 103 bits (257), Expect = 9e-22
Identities = 77/259 (29%), Positives = 127/259 (49%), Gaps = 26/259 (10%)
Query: 571 VWLKKFSLGDFGDLKSIK--SRASDVF----EMMKDLRHENINPLLGFFYDSGMFAIVTE 624
VW+ ++ +KS+K S + D F +MK L+H+ + L ++ I+TE
Sbjct: 259 VWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIY-IITE 317
Query: 625 FCSRGSLEDIL-TNQDVKLDWMFKSSLLLDLIKGMKYLHHREFVHGRLKSRNCVVDGRFV 683
+ GSL D L T +KL + + +GM ++ R ++H L++ N +V
Sbjct: 318 YMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLS 377
Query: 684 LKVTDYGFNDILEMLRLSEEESSMEELLWTAPELLRAPRGSRLGSFA--GDVYSFAIIMQ 741
K+ D+G ++E + E + + WTAPE + G+F DV+SF I++
Sbjct: 378 CKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAI------NYGTFTIKSDVWSFGILLT 431
Query: 742 EVMVRG-TPFCMMDLPAQEIINRLKKPPPVYRPVVPPEHAPPECLQLMKQCWAEAAEQRP 800
E++ G P+ M P E+I L++ YR +V P++ P E QLM+ CW E E RP
Sbjct: 432 EIVTHGRIPYPGMTNP--EVIQNLERG---YR-MVRPDNCPEELYQLMRLCWKERPEDRP 485
Query: 801 TFD---EIFNQFKTFNKGK 816
TFD + F T +G+
Sbjct: 486 TFDYLRSVLEDFFTATEGQ 504
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 101 bits (251), Expect = 4e-21
Identities = 74/255 (29%), Positives = 128/255 (50%), Gaps = 23/255 (9%)
Query: 565 IYEGDWVWLKKFSLGDFGDLKSIKSRASDVFE------MMKDLRHENINPLLGFFYDSGM 618
+YEG W KK+SL +K++K +V E +MK+++H N+ LLG
Sbjct: 256 VYEGVW---KKYSLTVA--VKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPP 310
Query: 619 FAIVTEFCSRGSLEDILTNQD-VKLDWMFKSSLLLDLIKGMKYLHHREFVHGRLKSRNCV 677
F I+TEF + G+L D L + +++ + + + M+YL + F+H L +RNC+
Sbjct: 311 FYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCL 370
Query: 678 VDGRFVLKVTDYGFNDILEMLRLSEEESSMEELLWTAPELLRAPRGSRLGSFAGDVYSFA 737
V ++KV D+G + ++ + + + WTAPE L + S DV++F
Sbjct: 371 VGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNK----FSIKSDVWAFG 426
Query: 738 IIMQEVMVRG-TPFCMMDLPAQEIINRLKKPPPVYRPVVPPEHAPPECLQLMKQCWAEAA 796
+++ E+ G +P+ +DL ++ L+K + R PE P + +LM+ CW
Sbjct: 427 VLLWEIATYGMSPYPGIDL--SQVYELLEKDYRMER----PEGCPEKVYELMRACWQWNP 480
Query: 797 EQRPTFDEIFNQFKT 811
RP+F EI F+T
Sbjct: 481 SDRPSFAEIHQAFET 495
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 101 bits (251), Expect = 4e-21
Identities = 74/255 (29%), Positives = 128/255 (50%), Gaps = 23/255 (9%)
Query: 565 IYEGDWVWLKKFSLGDFGDLKSIKSRASDVFE------MMKDLRHENINPLLGFFYDSGM 618
+YEG W KK+SL +K++K +V E +MK+++H N+ LLG
Sbjct: 275 VYEGVW---KKYSLTVA--VKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPP 329
Query: 619 FAIVTEFCSRGSLEDILTNQD-VKLDWMFKSSLLLDLIKGMKYLHHREFVHGRLKSRNCV 677
F I+TEF + G+L D L + +++ + + + M+YL + F+H L +RNC+
Sbjct: 330 FYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCL 389
Query: 678 VDGRFVLKVTDYGFNDILEMLRLSEEESSMEELLWTAPELLRAPRGSRLGSFAGDVYSFA 737
V ++KV D+G + ++ + + + WTAPE L + S DV++F
Sbjct: 390 VGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNK----FSIKSDVWAFG 445
Query: 738 IIMQEVMVRG-TPFCMMDLPAQEIINRLKKPPPVYRPVVPPEHAPPECLQLMKQCWAEAA 796
+++ E+ G +P+ +DL ++ L+K + R PE P + +LM+ CW
Sbjct: 446 VLLWEIATYGMSPYPGIDL--SQVYELLEKDYRMER----PEGCPEKVYELMRACWQWNP 499
Query: 797 EQRPTFDEIFNQFKT 811
RP+F EI F+T
Sbjct: 500 SDRPSFAEIHQAFET 514
>gi|50959205 adenylate cyclase 9 [Homo sapiens]
Length = 1353
Score = 100 bits (250), Expect = 6e-21
Identities = 77/240 (32%), Positives = 126/240 (52%), Gaps = 19/240 (7%)
Query: 831 YSSNLE-DLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSD 889
Y ++E DL R + + + + + + LL ++P VAE LK T + D + F+
Sbjct: 1008 YHGDVEADLHRTKIQSM---RDQADWLLRNIIPYHVAEQLKVSQTYS-KNHDSGGVIFAS 1063
Query: 890 IVGFTTISAMSEP--IEVVDLLNDLYTLFDAIIGSHD---VYKVETIGDAYMVASGL--- 941
IV F+ + E +LN+L FD ++ D + K++TIG YM ASGL
Sbjct: 1064 IVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTA 1123
Query: 942 PKRNGSR---HAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMP 998
++GS H + + +++ V F +M ++R+G + GP+ AGV+G T
Sbjct: 1124 QAQDGSHPQEHLQILFEFAKEMMRVVDDFN-NNMLWFNFKLRVGFNHGPLTAGVIGTTKL 1182
Query: 999 RYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETF 1058
Y ++GDTVN ASRM++TG+ RI VS + +L + GY+ + RG +KGKG +T+
Sbjct: 1183 LYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKM--GYDFDYRGTVNVKGKGQMKTY 1240
Score = 94.0 bits (232), Expect = 7e-19
Identities = 66/251 (26%), Positives = 122/251 (48%), Gaps = 43/251 (17%)
Query: 844 EELEIEKQKTEKLLTQMLPPSVAE------------SLKKGCTVEPEG------------ 879
++LE+EK E+++ ++P +A+ S+K+ T P+
Sbjct: 321 KDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPI 380
Query: 880 ---------FDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVET 930
+ V++ F+DIVGFT +SA +V LLNDL+ FD + K+ T
Sbjct: 381 AFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKIST 440
Query: 931 IGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVA 990
+GD Y +G P+ HA M L ++ ++ F + V +R+G+H+G V+
Sbjct: 441 LGDCYYCVAGCPEPRAD-HAYCCIEMGLGMIKAIEQFCQE--KKEMVNMRVGVHTGTVLC 497
Query: 991 GVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQN---LSEGYEVELRGRT 1047
G++G+ ++ ++ + VN A+ ME G+ ++H+S +T L + + +G +E G++
Sbjct: 498 GILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGKVIERLGQS 557
Query: 1048 ----ELKGKGT 1054
+LKG T
Sbjct: 558 VVADQLKGLKT 568
>gi|148536830 adenylate cyclase 3 [Homo sapiens]
Length = 1144
Score = 99.8 bits (247), Expect = 1e-20
Identities = 67/236 (28%), Positives = 118/236 (50%), Gaps = 16/236 (6%)
Query: 846 LEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDL-------------VTLYFSDIVG 892
LE + Q+ E L+ +LP VA+ + K + D V++ F+DIVG
Sbjct: 268 LEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVG 327
Query: 893 FTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAE 952
FT +S+ E+V LLN+L+ FD + + +++ +GD Y GLP HA
Sbjct: 328 FTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYR-EDHAVC 386
Query: 953 IANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASR 1012
M L ++ ++ +R + V +R+G+H+G V+ GV+G +Y ++ V A++
Sbjct: 387 SILMGLAMVEAIS--YVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANK 444
Query: 1013 MESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWLIGKKGFMK 1068
ME+ G+P R+H+S ST+ L+ + + R + + ET+ +I K +K
Sbjct: 445 MEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLEEKGIETYLIIASKPEVK 500
Score = 99.0 bits (245), Expect = 2e-20
Identities = 82/274 (29%), Positives = 137/274 (50%), Gaps = 42/274 (15%)
Query: 821 IDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAE----SLKKGCTVE 876
++ + R L + + D +ER E+ ++ E L+T MLP VA S K+ +
Sbjct: 860 VEKLARTLFLWKIEVHDQ-KERVYEM---RRWNEALVTNMLPEHVARHFLGSKKRDEELY 915
Query: 877 PEGFDLVTLYFSDIVGF----TTISAMSEPIEVVDLLNDLYTLFDAIIGSHD---VYKVE 929
+ +D + + F+ + F T S + IE + LN++ + FD+++ + + K++
Sbjct: 916 SQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIK 975
Query: 930 TIGDAYMVASGLP-----------------KRNGSRHAAEIANMSL---DILSSVGTFKM 969
TIG YM ASG+ +R +H A++A+ +L D L+++
Sbjct: 976 TIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSF 1035
Query: 970 RHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTV 1029
+ +RIG++ G V+AGV+G P Y ++G+TVN ASRMESTG+ I V T
Sbjct: 1036 NNF-----MLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQ 1090
Query: 1030 TILQNLSEGYEVELRGRTELKGKGTEETFWLIGK 1063
IL+ G+ RG +KGKG TF+L G+
Sbjct: 1091 VILREY--GFRFVRRGPIFVKGKGELLTFFLKGR 1122
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 98.6 bits (244), Expect = 3e-20
Identities = 75/255 (29%), Positives = 127/255 (49%), Gaps = 23/255 (9%)
Query: 565 IYEGDWVWLKKFSLGDFGDLKSIKSRASDVFE------MMKDLRHENINPLLGFFYDSGM 618
+Y G W KK+SL +K++K +V E +MK+++H N+ LLG
Sbjct: 287 VYVGVW---KKYSLTVA--VKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPP 341
Query: 619 FAIVTEFCSRGSLEDILTNQD-VKLDWMFKSSLLLDLIKGMKYLHHREFVHGRLKSRNCV 677
F IVTE+ G+L D L + ++ + + + M+YL + F+H L +RNC+
Sbjct: 342 FYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCL 401
Query: 678 VDGRFVLKVTDYGFNDILEMLRLSEEESSMEELLWTAPELLRAPRGSRLGSFAGDVYSFA 737
V V+KV D+G + ++ + + + WTAPE L S DV++F
Sbjct: 402 VGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL----AYNTFSIKSDVWAFG 457
Query: 738 IIMQEVMVRG-TPFCMMDLPAQEIINRLKKPPPVYRPVVPPEHAPPECLQLMKQCWAEAA 796
+++ E+ G +P+ +DL ++ + L+K YR + PE PP+ +LM+ CW +
Sbjct: 458 VLLWEIATYGMSPYPGIDL--SQVYDLLEKG---YR-MEQPEGCPPKVYELMRACWKWSP 511
Query: 797 EQRPTFDEIFNQFKT 811
RP+F E F+T
Sbjct: 512 ADRPSFAETHQAFET 526
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 98.6 bits (244), Expect = 3e-20
Identities = 75/255 (29%), Positives = 127/255 (49%), Gaps = 23/255 (9%)
Query: 565 IYEGDWVWLKKFSLGDFGDLKSIKSRASDVFE------MMKDLRHENINPLLGFFYDSGM 618
+Y G W KK+SL +K++K +V E +MK+++H N+ LLG
Sbjct: 302 VYVGVW---KKYSLTVA--VKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPP 356
Query: 619 FAIVTEFCSRGSLEDILTNQD-VKLDWMFKSSLLLDLIKGMKYLHHREFVHGRLKSRNCV 677
F IVTE+ G+L D L + ++ + + + M+YL + F+H L +RNC+
Sbjct: 357 FYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCL 416
Query: 678 VDGRFVLKVTDYGFNDILEMLRLSEEESSMEELLWTAPELLRAPRGSRLGSFAGDVYSFA 737
V V+KV D+G + ++ + + + WTAPE L S DV++F
Sbjct: 417 VGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL----AYNTFSIKSDVWAFG 472
Query: 738 IIMQEVMVRG-TPFCMMDLPAQEIINRLKKPPPVYRPVVPPEHAPPECLQLMKQCWAEAA 796
+++ E+ G +P+ +DL ++ + L+K YR + PE PP+ +LM+ CW +
Sbjct: 473 VLLWEIATYGMSPYPGIDL--SQVYDLLEKG---YR-MEQPEGCPPKVYELMRACWKWSP 526
Query: 797 EQRPTFDEIFNQFKT 811
RP+F E F+T
Sbjct: 527 ADRPSFAETHQAFET 541
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,826,077
Number of Sequences: 37866
Number of extensions: 1912023
Number of successful extensions: 6773
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 428
Number of HSP's successfully gapped in prelim test: 253
Number of HSP's that attempted gapping in prelim test: 5594
Number of HSP's gapped (non-prelim): 873
length of query: 1108
length of database: 18,247,518
effective HSP length: 113
effective length of query: 995
effective length of database: 13,968,660
effective search space: 13898816700
effective search space used: 13898816700
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.