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Search of human proteins with 55741643
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55741643 kelch-like 14 [Homo sapiens]
(628 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55741643 kelch-like 14 [Homo sapiens] 1305 0.0
gi|45643138 kelch-like 13 [Homo sapiens] 356 4e-98
gi|24308181 kelch-like 9 [Homo sapiens] 355 7e-98
gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo... 328 1e-89
gi|8922854 kelch-like 26 [Homo sapiens] 318 7e-87
gi|31542246 kelch-like 36 [Homo sapiens] 267 2e-71
gi|24432026 kelch-like [Homo sapiens] 229 8e-60
gi|226442729 kelch-like 15 [Homo sapiens] 223 4e-58
gi|156616301 kelch-like 32 [Homo sapiens] 223 5e-58
gi|14780904 kelch-like 1 protein [Homo sapiens] 219 5e-57
gi|23397572 kelch-like 34 [Homo sapiens] 217 3e-56
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 216 5e-56
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 216 5e-56
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 212 1e-54
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 211 2e-54
gi|166235129 kelch-like 3 [Homo sapiens] 210 3e-54
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 207 2e-53
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 207 2e-53
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 206 4e-53
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 206 4e-53
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 206 4e-53
gi|55925604 kelch-like 18 [Homo sapiens] 187 2e-47
gi|11056006 kelch-like 12 [Homo sapiens] 187 3e-47
gi|38194229 kelch-like 17 [Homo sapiens] 186 7e-47
gi|40807500 kelch-like 20 [Homo sapiens] 185 1e-46
gi|11545731 gigaxonin [Homo sapiens] 170 4e-42
gi|148664209 kelch-like 10 [Homo sapiens] 168 2e-41
gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 162 9e-40
gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain contai... 162 9e-40
gi|34101268 kelch-like 8 [Homo sapiens] 154 2e-37
>gi|55741643 kelch-like 14 [Homo sapiens]
Length = 628
Score = 1305 bits (3377), Expect = 0.0
Identities = 628/628 (100%), Positives = 628/628 (100%)
Query: 1 MSRSGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRS 60
MSRSGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRS
Sbjct: 1 MSRSGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRS 60
Query: 61 LFSSHPPLGGGVGGQDGLGAPKDQQQPPQQQPSQQQQPPPQEEPGTPSSSPDDKLLTSPR 120
LFSSHPPLGGGVGGQDGLGAPKDQQQPPQQQPSQQQQPPPQEEPGTPSSSPDDKLLTSPR
Sbjct: 61 LFSSHPPLGGGVGGQDGLGAPKDQQQPPQQQPSQQQQPPPQEEPGTPSSSPDDKLLTSPR 120
Query: 121 AINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQ 180
AINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQ
Sbjct: 121 AINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQ 180
Query: 181 ISVQNYKQVCKIAALHGLEETKKLANKYLVEDVLLLNFEEMRALLDSLPPPVESELALFQ 240
ISVQNYKQVCKIAALHGLEETKKLANKYLVEDVLLLNFEEMRALLDSLPPPVESELALFQ
Sbjct: 181 ISVQNYKQVCKIAALHGLEETKKLANKYLVEDVLLLNFEEMRALLDSLPPPVESELALFQ 240
Query: 241 MSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNY 300
MSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNY
Sbjct: 241 MSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNY 300
Query: 301 HLMPFRQHCRQSLASRIRSNKKMLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPY 360
HLMPFRQHCRQSLASRIRSNKKMLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPY
Sbjct: 301 HLMPFRQHCRQSLASRIRSNKKMLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPY 360
Query: 361 NSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYAC 420
NSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYAC
Sbjct: 361 NSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYAC 420
Query: 421 RLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVH 480
RLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVH
Sbjct: 421 RLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVH 480
Query: 481 NGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLVE 540
NGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLVE
Sbjct: 481 NGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLVE 540
Query: 541 CYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTWT 600
CYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTWT
Sbjct: 541 CYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTWT 600
Query: 601 ELEGDVAEPLAGPACVTVILPSCVPYNK 628
ELEGDVAEPLAGPACVTVILPSCVPYNK
Sbjct: 601 ELEGDVAEPLAGPACVTVILPSCVPYNK 628
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 356 bits (913), Expect = 4e-98
Identities = 214/633 (33%), Positives = 327/633 (51%), Gaps = 68/633 (10%)
Query: 2 SRSGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTA--QGQQFHCHKAVLASCSQYFR 59
S++G +HS +L G + L + L CDVTL F H+ ++AS S YF+
Sbjct: 61 SKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFK 120
Query: 60 SLFSSHPPLGGGVGGQDGLGAPKDQQQPPQQQPSQQQQPPPQEEPGTPSSSPDDKLLTSP 119
++F+ GG+ QD
Sbjct: 121 AMFT------GGMKEQD------------------------------------------- 131
Query: 120 RAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLND 179
+ + L G S +GLR +++++YTA ++L++D +++ L + L I V C FL
Sbjct: 132 --LMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLIS 189
Query: 180 QISVQNYKQVCKIAALHGLEETKKLANKYLVE---------DVLLLNFEEMRALLDSLPP 230
+++ N +V +IA + L E K N ++++ + L L FE + +L S
Sbjct: 190 GVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSL 249
Query: 231 PVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVC 290
+EL LF+ + WL + E RM +A LMK +RF L+ EL+ VQ+VDFMRTD C
Sbjct: 250 KHCTELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTC 308
Query: 291 QKLLLDAMNYHLMPFRQHCRQSLASRIRSNKKMLLLVGGLPPGPDRLPSNLVQYYDDEKK 350
LLL+A NY +MP+ Q QS + IRS+ L+ +GG+ + S ++ YD++
Sbjct: 309 VNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLR-QQLVVSKELRMYDEKAH 367
Query: 351 TWKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPM 410
WK L M H + + NFL+V+GG+ ++ GK + + V R+DPR+N W+Q+ +
Sbjct: 368 EWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASL 427
Query: 411 QERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHN 470
E+R F+ L +LY +GGRN G L +VECYN TNEW YV+ + +P HAG V+
Sbjct: 428 NEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYG 487
Query: 471 GKIYISGGVHNGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKG 530
G +YISGG+ + + L C+DP D W +K M T R +H + + +RLY IGGNH +G
Sbjct: 488 GVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRG 547
Query: 531 FS-HLDVMLVECYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSST 589
S + DV+ E Y P DQW + +L G+S G AV ++ IY+VGGYSW+
Sbjct: 548 TSDYDDVLSCEYYSPILDQWTPI-AAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIV 606
Query: 590 ICYCPEKGTWTELEGDVAEPLAG-PACVTVILP 621
Y P+K W ++ D+ E L G AC + P
Sbjct: 607 QKYDPDKDEWHKV-FDLPESLGGIRACTLTVFP 638
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 355 bits (911), Expect = 7e-98
Identities = 211/621 (33%), Positives = 326/621 (52%), Gaps = 68/621 (10%)
Query: 14 SHSDNLLHGLNLLWRKQLFCDVTLT-AQGQQ-FHCHKAVLASCSQYFRSLFSSHPPLGGG 71
+HS +L G + L + L CDVTL G + F H+A++AS S YF+++F+ GG
Sbjct: 31 THSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFT------GG 84
Query: 72 VGGQDGLGAPKDQQQPPQQQPSQQQQPPPQEEPGTPSSSPDDKLLTSPRAINNLVLQGCS 131
+ QD + + L G +
Sbjct: 85 MKEQD---------------------------------------------LMCIKLHGVN 99
Query: 132 SIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCK 191
+GL+ +++++YTA ++L++D +++ L + L I V C FL +S+ N +V +
Sbjct: 100 KVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGR 159
Query: 192 IAALHGLEETKKLANKYLVE---------DVLLLNFEEMRALLDSLPPPVESELALFQMS 242
IA + L E K N ++++ + L L FE + +L S +EL LF+ +
Sbjct: 160 IANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKAA 219
Query: 243 VLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNYHL 302
WL + + RM YA LMK +RF L+ +L+ VQ+VDFMRTD C LLL+A NY +
Sbjct: 220 CRWLRLE-DPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLLLEASNYQM 278
Query: 303 MPFRQHCRQSLASRIRSNKKMLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPYNS 362
MP+ Q QS + IRS+ L+ +GG+ + S ++ YD+ + W+ L M
Sbjct: 279 MPYMQPVMQSDRTAIRSDSTHLVTLGGVLR-QQLVVSKELRMYDERAQEWRSLAPMDAPR 337
Query: 363 AHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYACRL 422
H + + NFL+V+GG+ ++ GK + + V R+DPR+N W+Q+ + E+R F+ L
Sbjct: 338 YQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSAL 397
Query: 423 DKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVHNG 482
HLY +GGR+ G L++VECYN NEW YV+ + +P HAG V+ G +YISGG+ +
Sbjct: 398 KGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHD 457
Query: 483 EYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFS-HLDVMLVEC 541
+ L C+DP D W +K M T R +H + + D+LY IGGNH +G S + DV+ E
Sbjct: 458 TFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEY 517
Query: 542 YDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTWTE 601
Y P DQW + +L G+S G AV ++ IY+VGGYSW+ Y PEK W +
Sbjct: 518 YSPTLDQWTPI-AAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHK 576
Query: 602 LEGDVAEPLAG-PACVTVILP 621
+ D+ E L G AC + P
Sbjct: 577 V-FDLPESLGGIRACTLTVFP 596
>gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo
sapiens]
Length = 634
Score = 328 bits (840), Expect = 1e-89
Identities = 191/523 (36%), Positives = 285/523 (54%), Gaps = 18/523 (3%)
Query: 115 LLTSPRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCV 174
+L +I + L S +GL V+ Y YT +TLSL T+ ++S + L I + K+C
Sbjct: 101 ILKKDPSIQRVDLNDISPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCS 160
Query: 175 QFLNDQISVQNYKQVCKIAALHGLEETKKLANKYLVEDVL---------LLNFEEMRALL 225
FL ++SV+N V IA + L+ K A K++ ++ L L FE++ LL
Sbjct: 161 DFLIREMSVENCMYVVNIAETYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINELL 220
Query: 226 DSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMR 285
+ SE+ FQ+++ WLE D++ R++YA DL+ +RF I A +LV VQSV M
Sbjct: 221 IDDDLQLPSEIVAFQIAMKWLEFDQK-RVKYAADLLSNIRFGTISAQDLVNYVQSVPRMM 279
Query: 286 TDPVCQKLLLDAMNYHLMPFRQHCRQSLASRIRSNKKMLLLVGGLPPGPDRLPSNLVQYY 345
D C +LL+DAMNYHL+P+ Q+ QS +RIR ++L+ VGG P ++ S + Y
Sbjct: 280 QDADCHRLLVDAMNYHLLPYHQNTLQSRRTRIRGGCRVLVTVGGRPGLTEKSLSRDILYR 339
Query: 346 DDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNG--KHSTNFVSRYDPRFNS 403
D E W LT MP S + CV ++ FL+V GGEDQ + KH+ + RYDPRFN+
Sbjct: 340 DPENG-WSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNT 398
Query: 404 WIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAA 463
WI L M ++R F + +Y GGRN G L+S+ECY TN+W+ + L
Sbjct: 399 WIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEVARCC 458
Query: 464 HAGAVHNGKIYISGGVHNGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAI 523
HA AV +G++ ++GG Y + YDP D W +++T R H ++DR+Y +
Sbjct: 459 HASAVADGRVLVTGGYIANAYSRSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVM 518
Query: 524 GGNHL--KGFSHLDVMLVECYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWS 581
GG+ L +G +DV+ VECY P QW+ P+ G S G + L YLVGG++
Sbjct: 519 GGSQLGPRG-ERVDVLTVECYSPATGQWS-YAAPLQVGVSTAGVSALHGRAYLVGGWNEG 576
Query: 582 MGAYKSSTICYCPEKGTWTELEGDVAEPLAGPACVTVILPSCV 624
YK C+ PE WTE + ++ E G +C T+ +P+ V
Sbjct: 577 EKKYKKCIQCFSPELNEWTE-DDELPEATVGVSCCTLSMPNNV 618
Score = 50.1 bits (118), Expect = 6e-06
Identities = 20/57 (35%), Positives = 35/57 (61%)
Query: 12 DPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPL 68
D S+ NLL GL+ + ++ CD+ + + + F HK+V+ASCS+YF ++ P +
Sbjct: 52 DASYGPNLLEGLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKKDPSI 108
>gi|8922854 kelch-like 26 [Homo sapiens]
Length = 615
Score = 318 bits (816), Expect = 7e-87
Identities = 212/632 (33%), Positives = 316/632 (50%), Gaps = 67/632 (10%)
Query: 3 RSGDRTSTFD-PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSL 61
++G TF PSHS +LL GL L + DV LT + F HK VLA+CS YFR++
Sbjct: 32 KNGALKCTFSAPSHSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAM 91
Query: 62 FSSHPPLGGGVGGQDGLGAPKDQQQPPQQQPSQQQQPPPQEEPGTPSSSPDDKLLTSPRA 121
F+ GG+ ++ SQ
Sbjct: 92 FT------GGM-----------------REASQDV------------------------- 103
Query: 122 INNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQI 181
+ L+G S+ GLR ++++ Y+A VTL LD V++VL + L + V +LC +FL +
Sbjct: 104 ---IELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAM 160
Query: 182 SVQNYKQVCKIAALHGLEETKKLANKYLV---------EDVLLLNFEEMRALLDSLPPPV 232
SV+ + ++A L ++ + + ED L L E + L S
Sbjct: 161 SVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQS 220
Query: 233 ESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQK 292
+E+ LF+ +V WL+HD R + A ++ +RF L+ + ELV+ VQ++D M D +C++
Sbjct: 221 CAEIDLFRAAVRWLQHDPARRPR-ASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLCRQ 279
Query: 293 LLLDAMNYHLMPFRQHCRQSLASRIRSNKKMLLLVGGLP-PGPDR-LPSNLVQYYDDEKK 350
LL+A NY ++PFRQH QS + +RS+ L+ GG P DR + S + Q + +
Sbjct: 280 YLLEAFNYQVLPFRQHEMQSPRTAVRSDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPGAR 339
Query: 351 TWKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPM 410
++ LT M +H CV ++NF++V GG+ +G+ + + RYDP N W++L M
Sbjct: 340 HFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQAM 399
Query: 411 QERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHN 470
QE R F L +Y GGRN G L+SVE Y NEW Y SL + HAGA
Sbjct: 400 QESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAGAASG 459
Query: 471 GKIYISGGVH-NGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLK 529
G++YISGG + E L+CYDPV D W K M+ R +H + R+YA+GG
Sbjct: 460 GRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGRMDH 519
Query: 530 GFSHLDVMLVECYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSST 589
DV+ VE Y P+ DQW + +P+ G+S GC +L+ IY+VGGY+W +
Sbjct: 520 VDRCFDVLAVEYYVPETDQWTSV-SPMRAGQSEAGCCLLERKIYIVGGYNWRLNNVTGIV 578
Query: 590 ICYCPEKGTWTELEGDVAEPLAGPACVTVILP 621
Y + W E + E AG AC V+LP
Sbjct: 579 QVYNTDTDEW-ERDLHFPESFAGIACAPVLLP 609
>gi|31542246 kelch-like 36 [Homo sapiens]
Length = 616
Score = 267 bits (683), Expect = 2e-71
Identities = 161/512 (31%), Positives = 262/512 (51%), Gaps = 20/512 (3%)
Query: 127 LQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNY 186
L G S IGL+ V+++LY + L ++ VL + +L I V C ++L ++S NY
Sbjct: 89 LIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDNY 148
Query: 187 KQVCKIAALHGLEETKKLANKYLVEDVLLLNF----------EEMRALLDSLPPPVESEL 236
+ ++A+++ L+ + +++ L+F +++ L S E E
Sbjct: 149 LYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLSSSEVQRECEH 208
Query: 237 ALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSV--DFMRTDPVCQKLL 294
L Q ++ WL E R +A +++ + F LIP +L+ RV+ + + C+ +
Sbjct: 209 DLLQAALQWLTQQPE-REAHARQVLENIHFPLIPKNDLLHRVKPAVCSLLPKEANCEGFI 267
Query: 295 LDAMNYHLMPFRQHCRQSLASRIRSNKKMLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKI 354
+A+ YH Q Q+ + +R+N++ LL VGG S+ Y D + + W
Sbjct: 268 EEAVRYHNNLAAQPVMQTKRTALRTNQERLLFVGGEVSERCLELSDDTCYLDAKSEQWVK 327
Query: 355 LTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERR 414
T +P +HHCV + F+F+ GG + G ++N + RYDPR WI++ M +RR
Sbjct: 328 ETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIKVASMNQRR 387
Query: 415 ASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIY 474
FY ++ L IGGRNE G LSSVE Y+ +T+ W YV+ LP+ HAG ++ +Y
Sbjct: 388 VDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAGTIYKDFVY 447
Query: 475 ISGG--VHNGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGG--NHLKG 530
ISGG G Y L CYD DVW ++ M T R H++ + D +Y+IGG ++++
Sbjct: 448 ISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSDDNIES 507
Query: 531 FSHLDVMLVECYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTI 590
DV+ VE Y P+ +QW + P+L S G AV + IY++GGYSW A+ +
Sbjct: 508 MERFDVLGVEAYSPQCNQWTRV-APLLHANSESGVAVWEGRIYILGGYSWENTAFSKTVQ 566
Query: 591 CYCPEKGTWTELEGDVAEPLA-GPACVTVILP 621
Y E W+ D+ + +A G ACV + P
Sbjct: 567 VYDREADKWSR-GVDLPKAIAGGSACVCALEP 597
Score = 45.8 bits (107), Expect = 1e-04
Identities = 22/49 (44%), Positives = 29/49 (59%)
Query: 15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS 63
HS +L LN + LFCDV L A Q+ H+ +LA CS YF S+F+
Sbjct: 28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFT 76
>gi|24432026 kelch-like [Homo sapiens]
Length = 634
Score = 229 bits (583), Expect = 8e-60
Identities = 166/622 (26%), Positives = 289/622 (46%), Gaps = 74/622 (11%)
Query: 15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPLGGGVGG 74
HS LL GL L + DV L +G+ H+ +LA+ YFR +F+
Sbjct: 32 HSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFA----------- 80
Query: 75 QDGLGAPKDQQQPPQQQPSQQQQPPPQEEPGTPSSSPDDKLLTSPRAINNLVLQGCSSIG 134
G K+ +Q +++ G S
Sbjct: 81 ----GGLKEMEQ------------------------------------EEVLIHGVSYNA 100
Query: 135 LRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCKIAA 194
+ +L ++YT+ + LSL V+E L + L IP++ C FL + +N V ++A
Sbjct: 101 MCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENILDVYRLAE 160
Query: 195 LHGLEETKKLANKYLVEDVLL---------LNFEEMRALLDSLPPPVESELALFQMSVLW 245
L L + + Y++++ + L E++ +LL S V E +++ ++L+
Sbjct: 161 LFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLY 220
Query: 246 ---LEHDR--ETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNY 300
LE + + + P L++ +RF L+ A E+++R+ D + P+ + + A+ Y
Sbjct: 221 HYSLEQVQADQISLHEPPKLLETVRFPLMEA-EVLQRLH--DKLDPSPL-RDTVASALMY 276
Query: 301 HLMPFRQHCRQSLASRIRSNKKMLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTI-MP 359
H Q QS + +RS+ + ++ GG+ P + S+ +Y + WK T +
Sbjct: 277 HRNESLQPSLQSPQTELRSDFQCVVGFGGIHSTPSTVLSDQAKYLNPLLGEWKHFTASLA 336
Query: 360 YNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYA 419
++ + + NF++++GG++ N G + + RYDPR N W Q+ +Q+ A
Sbjct: 337 PRMSNQGIAVLNNFVYLIGGDN--NVQGFRAESRCWRYDPRHNRWFQIQSLQQEHADLSV 394
Query: 420 CRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISGGV 479
C + +++Y + GR+ L++VE Y+ TN W YV+ L + + AHAGA GK+YI+ G
Sbjct: 395 CVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKREVYAHAGATLEGKMYITCGR 454
Query: 480 HNGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLV 539
+Y+ +CYDP + W D +RA H +A + ++LY IGG++ DV V
Sbjct: 455 RGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMATLLNKLYVIGGSNNDAGYRRDVHQV 514
Query: 540 ECYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTW 599
CY QW+ + P+ G PG AVLD+ IY++GG S + G+ Y EK W
Sbjct: 515 ACYSCTSGQWSSV-CPLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRTGYVHIYDVEKDCW 573
Query: 600 TELEGDVAEPLAGPACVTVILP 621
E + ++G A + LP
Sbjct: 574 EE-GPQLDNSISGLAACVLTLP 594
>gi|226442729 kelch-like 15 [Homo sapiens]
Length = 604
Score = 223 bits (568), Expect = 4e-58
Identities = 167/632 (26%), Positives = 286/632 (45%), Gaps = 91/632 (14%)
Query: 4 SGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS 63
+GD H ++ G L+ + L DVTL + QF HKA+LA+ S YFR +F+
Sbjct: 2 AGDVEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFT 61
Query: 64 SHPPLGGGVGGQDGLGAPKDQQQPPQQQPSQQQQPPPQEEPGTPSSSPDDKLLTSPRAIN 123
+ D ++ Q +
Sbjct: 62 A------------------DMRERDQDK-------------------------------- 71
Query: 124 NLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISV 183
+ L+G ++ G VL+++Y + LS++TV E+L + + + +V K C FL +I +
Sbjct: 72 -IHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICL 130
Query: 184 QNYKQVCKIAALHG--LEETKKLANKYLVEDVL----------LLNFEEMRALLDSLPPP 231
+N ++ ++ G +E ++ + +L+++ + L+FE++ + LD+
Sbjct: 131 ENCAEIMRLLDDFGVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLS 190
Query: 232 VESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQ 291
E+ L++ WL HDR R ++ +++ +RF L+ + E+V++ +F R +
Sbjct: 191 RFPEIELYEAVQSWLRHDRR-RWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFYRYSRQLR 249
Query: 292 KLLLDAMNYHLMPFRQHCRQSLASRIRSNKKMLLLVGGLPPGPDRLPSNLVQYYDDEKKT 351
+ A+NY +Q +SRIRS K + G+ G + S ++ + +
Sbjct: 250 YEVDQALNYFQNVHQQPLLDMKSSRIRSAKPQTTVFRGMI-GHSMVNSKILLL--KKPRV 306
Query: 352 WKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNGK-HSTNFVSRYDPRFNSWIQLPPM 410
W L C+ V NF+F+LGGE+ P+G+ H+++ V RYDPR NSW+Q+ M
Sbjct: 307 WWELEGPQVPLRPDCLAIVNNFVFLLGGEEL-GPDGEFHASSKVFRYDPRQNSWLQMADM 365
Query: 411 QERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHN 470
R+ F + K +Y + GR S E Y++ ++W +V P H G V N
Sbjct: 366 SVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLN 425
Query: 471 GKIYISGGVHNGEYVPWLYCYDP---------------VMDVWARKQDMNTKRAIHTLAV 515
K++I+GG+ + + +DP V + W K MN R H +
Sbjct: 426 NKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMIS 485
Query: 516 MNDRLYAIGGNHL---KGFSHLDVMLVECYDPKGDQWNILQT-PILEGRSGPGCAVLDDS 571
N +LY GG + F E Y+P+ DQW IL + PI GRSG G VLD
Sbjct: 486 YNGKLYVFGGVCVILRASFESQGCPSTEVYNPETDQWTILASMPI--GRSGHGVTVLDKQ 543
Query: 572 IYLVGGYSWSMGAYKSSTICYCPEKGTWTELE 603
I ++GG ++ G Y S + + P++ W E E
Sbjct: 544 IMVLGGLCYN-GHYSDSILTFDPDENKWKEDE 574
>gi|156616301 kelch-like 32 [Homo sapiens]
Length = 620
Score = 223 bits (567), Expect = 5e-58
Identities = 145/476 (30%), Positives = 240/476 (50%), Gaps = 27/476 (5%)
Query: 127 LQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNY 186
L G +S+GL+ LE+ YT + L +++VL+ L + ++ LC +L +++ NY
Sbjct: 85 LHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNY 144
Query: 187 KQVCKIAALHGLEETKKLANKYLV-----------EDVLLLNFEEMRALLDSLPPPVESE 235
+ ++A L L +K +LV E+VL L + ++ +L S SE
Sbjct: 145 LDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKSDRLTSLSE 204
Query: 236 LALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLL 295
++Q++V WLEH+ QY +L++ +RF L+ L S ++ L+
Sbjct: 205 EQIWQLAVRWLEHN--CHYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQASETATALVN 262
Query: 296 DAMNYHLMPFRQHCRQSLASRIRSNKKMLLLVGGLPPGPDRLPSNLVQYYD--DEKKT-- 351
+A+ YH + Q Q+ ++ R L ++GG ++ ++Y++ D++
Sbjct: 263 EALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKREVCKVKE--LRYFNPVDQENALI 320
Query: 352 -----WKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQ 406
W L MP +HHCV + +FLFV GGE + + RYDPR NSW +
Sbjct: 321 AAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRYDPRSNSWAE 380
Query: 407 LPPMQERRASFYACRLDKHLYVIGGRNE-TGYLSSVECYNLETNEWRYVSSLPQPLAAHA 465
+ PM+ R F ++++LY +GGRNE L +VE Y + N+W +V S + L+ HA
Sbjct: 381 IAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHA 440
Query: 466 GAVHNGKIYISGGVHN-GEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIG 524
G V +G ++ISGGV N +Y L Y+P + W + M +R H++A + +LY +G
Sbjct: 441 GYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLG 500
Query: 525 GNHLK-GFSHLDVMLVECYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYS 579
GN L + V ++ Y+ DQW +L G++ G AV + IYLVGGYS
Sbjct: 501 GNDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYLVGGYS 556
Score = 61.6 bits (148), Expect = 2e-09
Identities = 27/50 (54%), Positives = 37/50 (74%)
Query: 14 SHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS 63
SH+D++L LN + CD+TL A+ Q+FH HKAVLA+CS YFR++FS
Sbjct: 23 SHNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFS 72
Score = 43.9 bits (102), Expect = 4e-04
Identities = 28/104 (26%), Positives = 45/104 (43%), Gaps = 3/104 (2%)
Query: 498 WARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLVEC-YDPKGDQWNILQTPI 556
W+ M R+ H +AVM D L+ GG + C YDP+ + W + P+
Sbjct: 326 WSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRYDPRSNSWAEI-APM 384
Query: 557 LEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTWT 600
R +++ +Y VGG + + + YCP+K WT
Sbjct: 385 KNCREHFVLGAMEEYLYAVGGRN-ELRQVLPTVERYCPKKNKWT 427
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 219 bits (559), Expect = 5e-57
Identities = 165/617 (26%), Positives = 279/617 (45%), Gaps = 77/617 (12%)
Query: 15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPLGGGVGG 74
H++ + ++Q CDV L ++ H+ VL+S S YF ++F+S
Sbjct: 194 HAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTS---------- 243
Query: 75 QDGLGAPKDQQQPPQQQPSQQQQPPPQEEPGTPSSSPDDKLLTSPRAINNLVLQGCSSIG 134
D + Q++ + ++G
Sbjct: 244 --------DVCEAKQEE---------------------------------IKMEGIDPNA 262
Query: 135 LRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCKIAA 194
L ++++ YT + L DT+E +L+ + +L +PQV ++C FL + N + A
Sbjct: 263 LWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFAD 322
Query: 195 LHGLEETKKLANKYLVEDV---------LLLNFEEMRALLDSLPPPVESELALFQMSVLW 245
G E K+A+ Y +E++ LLL EE+ LL S V E +F ++W
Sbjct: 323 AQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMW 382
Query: 246 LEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNYHLMPF 305
+++D ++R L+ +R L+P P+++ +++ + D CQKL+L+AM YHL+P
Sbjct: 383 VKYDMQSRCNDLSMLLAFIRLPLLP-PQILADLENHALFKNDLECQKLILEAMKYHLLPE 441
Query: 306 RQHCRQSLASRIR-SNKKMLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPYNSAH 364
R+ QS ++ R S L VGG+ + + ++ YD W +M
Sbjct: 442 RRTLMQSPRTKPRKSTVGTLYAVGGM---DNNKGATTIEKYDLRTNLWIQAGMMNGRRLQ 498
Query: 365 HCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLDK 424
V +++ LFV+GG D G + N V Y+P+ +W LPPM R L+
Sbjct: 499 FGVAVIDDKLFVIGGRD-----GLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEG 553
Query: 425 HLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVHNGEY 484
+Y +GG + YL++VE ++ ++ +W +V+S+ + A NGK+Y GG
Sbjct: 554 PIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSC 613
Query: 485 VPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVML--VECY 542
+ + YDP + W M +R +A + LYA+GG+ +H +L VE Y
Sbjct: 614 LSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERY 673
Query: 543 DPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTWTEL 602
DPK D W ++ P+ R G +L D +Y VGGY Y ++ Y P+ WT++
Sbjct: 674 DPKTDTWTMV-APLSMPRDAVGVCLLGDRLYAVGGYDGQ--TYLNTMESYDPQTNEWTQM 730
Query: 603 EGDVAEPLAGPACVTVI 619
+ AG ACV VI
Sbjct: 731 -ASLNIGRAG-ACVVVI 745
>gi|23397572 kelch-like 34 [Homo sapiens]
Length = 644
Score = 217 bits (552), Expect = 3e-56
Identities = 163/517 (31%), Positives = 251/517 (48%), Gaps = 78/517 (15%)
Query: 131 SSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVC 190
S+ GL+ +L+++YTA ++LS+DTVE+ L + L + + LC ++L Q++ +N
Sbjct: 76 SAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENCCFAA 135
Query: 191 KIAALHGLEETKKLANKYLVE-------------DVLLLNFEEMRALLDSLPPPVESELA 237
+AA GL T A + +V +L LN +RA+L + E
Sbjct: 136 NVAARFGLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDVARVPEAR 195
Query: 238 LFQMSVLWLEHDRET-RMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLD 296
L +++ WL + T R+ + +L++R+RF L+PA +++ RV S + + L++
Sbjct: 196 LLGLALAWLRQEPTTERLAHCTELLERVRFGLVPA-DVLRRVYSGSGLVLPARVKGLIIQ 254
Query: 297 AMNYHLMPFRQHCRQSLASRIRSNKKMLLLVGG----------------------LPPGP 334
A+NYH P RQ Q + IRS + +LLVGG P P
Sbjct: 255 ALNYHTTPSRQPLMQGEQTSIRSPQTRILLVGGRRAREVVIEEVAAPQRAARGQVAAPEP 314
Query: 335 DRLPSNLVQYYDDEK--------------KTWKILTIMPYNSAHHCVVEVENFLFVLGGE 380
+ L + ++E+ W+ LT +P H V NFLFVLGGE
Sbjct: 315 EEEEEELEEEEEEEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFLFVLGGE 374
Query: 381 DQWNPNGKHS----------TNFVSRYDPRFNSWIQLPPMQERRASFYACRLDKHLYVIG 430
+P+G S T V RYDPRF++W ++P M+E RA F+ + + L +G
Sbjct: 375 ---SPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERLLAVG 431
Query: 431 GRNETG-YLSSVECYNLETNEWRYVSSLPQPLAAHAGAV-HNGKIYISGG-VHNGE---- 483
G G L+SVE Y+L + W +LP+ L HAGAV G +YISGG GE
Sbjct: 432 GLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGKAGRGEGGAS 491
Query: 484 YVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLVECYD 543
+ LY P VW++K M T R H +AV+ ++A G + + FS +E YD
Sbjct: 492 SLRDLYVLGPEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLGRY-EPFSE-----IERYD 545
Query: 544 PKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSW 580
P DQW L+ P+ R G AV++++ L+GG W
Sbjct: 546 PGADQWTRLR-PLPYDRFCYGLAVVEETALLLGGLKW 581
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 216 bits (550), Expect = 5e-56
Identities = 170/635 (26%), Positives = 279/635 (43%), Gaps = 90/635 (14%)
Query: 10 TFDPSHSDNLLHGLN-----------LLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYF 58
T +P SD LN L KQL CDV L A ++ H+ VL+S S YF
Sbjct: 141 TMEPCTSDEFFQALNHAEQTFKKMENYLRHKQL-CDVILVAGDRRIPAHRLVLSSVSDYF 199
Query: 59 RSLFSSHPPLGGGVGGQDGLGAPKDQQQPPQQQPSQQQQPPPQEEPGTPSSSPDDKLLTS 118
++F++ D ++ Q++
Sbjct: 200 AAMFTN------------------DVREARQEE--------------------------- 214
Query: 119 PRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLN 178
+ ++G L +++Y YT + L D +E +LS + +L + QV + C +FL
Sbjct: 215 ------IKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLM 268
Query: 179 DQISVQNYKQVCKIAALHGLEETKKLANKYLVE---------DVLLLNFEEMRALLDSLP 229
Q+ N + A G + K+A+ Y +E + +LL E+ LL S
Sbjct: 269 KQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDD 328
Query: 230 PPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPV 289
+ +E + + W+ HD E R + L+ +R L+ AP+ + +++ R D
Sbjct: 329 MNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL-APQFLADMENNVLFRDDIE 387
Query: 290 CQKLLLDAMNYHLMPFRQHCRQSLASRIR-SNKKMLLLVGGLPPGPDRLPSNLVQYYDDE 348
CQKL+++AM YHL+P R+ QS ++ R S L VGG+ + ++ YD
Sbjct: 388 CQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKG---ATSIEKYDLR 444
Query: 349 KKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLP 408
W + M V +++ L+V+GG D G + N V Y+P+ +W +P
Sbjct: 445 TNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRD-----GLKTLNTVECYNPKTKTWSVMP 499
Query: 409 PMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAV 468
PM R L+ +Y +GG + YL++VE ++ + +W +V+++ P + AV
Sbjct: 500 PMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAV 559
Query: 469 HNGKIYISGGVHNGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHL 528
+GK+Y GG + + C+DP + W M+ +R + N LYAIGG H
Sbjct: 560 LSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGG-HD 618
Query: 529 KGFSHLDVMLVEC---YDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAY 585
S+L L +C YDPK D W + + + R G +L D +Y VGGY AY
Sbjct: 619 APASNLTSRLSDCVERYDPKTDMWTAVASMSI-SRDAVGVCLLGDKLYAVGGYDGQ--AY 675
Query: 586 KSSTICYCPEKGTWTELEGDVAEPLAGPACVTVIL 620
++ Y P+ WT++ + AG VTV L
Sbjct: 676 LNTVEAYDPQTNEWTQV-APLCLGRAGACVVTVKL 709
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 216 bits (550), Expect = 5e-56
Identities = 170/635 (26%), Positives = 279/635 (43%), Gaps = 90/635 (14%)
Query: 10 TFDPSHSDNLLHGLN-----------LLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYF 58
T +P SD LN L KQL CDV L A ++ H+ VL+S S YF
Sbjct: 187 TMEPCTSDEFFQALNHAEQTFKKMENYLRHKQL-CDVILVAGDRRIPAHRLVLSSVSDYF 245
Query: 59 RSLFSSHPPLGGGVGGQDGLGAPKDQQQPPQQQPSQQQQPPPQEEPGTPSSSPDDKLLTS 118
++F++ D ++ Q++
Sbjct: 246 AAMFTN------------------DVREARQEE--------------------------- 260
Query: 119 PRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLN 178
+ ++G L +++Y YT + L D +E +LS + +L + QV + C +FL
Sbjct: 261 ------IKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLM 314
Query: 179 DQISVQNYKQVCKIAALHGLEETKKLANKYLVE---------DVLLLNFEEMRALLDSLP 229
Q+ N + A G + K+A+ Y +E + +LL E+ LL S
Sbjct: 315 KQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDD 374
Query: 230 PPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPV 289
+ +E + + W+ HD E R + L+ +R L+ AP+ + +++ R D
Sbjct: 375 MNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL-APQFLADMENNVLFRDDIE 433
Query: 290 CQKLLLDAMNYHLMPFRQHCRQSLASRIR-SNKKMLLLVGGLPPGPDRLPSNLVQYYDDE 348
CQKL+++AM YHL+P R+ QS ++ R S L VGG+ + ++ YD
Sbjct: 434 CQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKG---ATSIEKYDLR 490
Query: 349 KKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLP 408
W + M V +++ L+V+GG D G + N V Y+P+ +W +P
Sbjct: 491 TNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRD-----GLKTLNTVECYNPKTKTWSVMP 545
Query: 409 PMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAV 468
PM R L+ +Y +GG + YL++VE ++ + +W +V+++ P + AV
Sbjct: 546 PMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAV 605
Query: 469 HNGKIYISGGVHNGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHL 528
+GK+Y GG + + C+DP + W M+ +R + N LYAIGG H
Sbjct: 606 LSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGG-HD 664
Query: 529 KGFSHLDVMLVEC---YDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAY 585
S+L L +C YDPK D W + + + R G +L D +Y VGGY AY
Sbjct: 665 APASNLTSRLSDCVERYDPKTDMWTAVASMSI-SRDAVGVCLLGDKLYAVGGYDGQ--AY 721
Query: 586 KSSTICYCPEKGTWTELEGDVAEPLAGPACVTVIL 620
++ Y P+ WT++ + AG VTV L
Sbjct: 722 LNTVEAYDPQTNEWTQV-APLCLGRAGACVVTVKL 755
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 212 bits (539), Expect = 1e-54
Identities = 173/608 (28%), Positives = 273/608 (44%), Gaps = 84/608 (13%)
Query: 15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPLGGGVGG 74
HS+ LL GLNLL + CD+ L + H HK VLAS S YF+++F+ +
Sbjct: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGN--------- 67
Query: 75 QDGLGAPKDQQQPPQQQPSQQQQPPPQEEPGTPSSSPDDKLLTSPRAINNLVLQGCSSIG 134
S + + + Q
Sbjct: 68 ------------------------------------------LSEKENSEVEFQCIDETA 85
Query: 135 LRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCKIAA 194
L+ ++EY YT V +S DTVE +L + +L I V K C FL Q+ N + + A
Sbjct: 86 LQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGNCIGISRFAE 145
Query: 195 LHGLEETKKLANKYLVEDVLLLN-----FEEMRALLDSLPPP----VESELALFQMSVLW 245
+G + A KY+ ++ + FE A LD + V +E +F W
Sbjct: 146 TYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEETVFYALESW 205
Query: 246 LEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNYHLMPF 305
+++D + R +Y L+ +R L+ L ++ +R D C+ LL +A+ YH MP
Sbjct: 206 IKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNEALKYHFMPE 265
Query: 306 RQHCRQS-LASRIRSNKKMLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPYNSAH 364
+ Q+ L +R R K+L VGG L S V+ Y + +W + + P N
Sbjct: 266 HRLSHQTVLMTRPRCAPKVLCAVGGKSGLFACLDS--VEMYFPQNDSW--IGLAPLNIPR 321
Query: 365 H----CVVEVENFLFVLGGEDQWNPNG----KHSTNFVSRYDPRFNSWIQLPPMQERRAS 416
+ CV++ + ++V+GG G KH N V ++P N+W L M E R++
Sbjct: 322 YEFGICVLDQK--VYVIGGIATNVRPGVTIRKHE-NSVECWNPDTNTWTSLERMNESRST 378
Query: 417 FYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYIS 476
L LY +GG + YL SVE Y + +W+ V+ + + A AV +G IY
Sbjct: 379 LGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAI 438
Query: 477 GGVHNGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDV 536
GG + ++ + YDP D W M KR + VM ++ +GG++ G SHL
Sbjct: 439 GG-YGPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHN--GVSHLS- 494
Query: 537 MLVECYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEK 596
+E YDP +QW + + P+ E R+G G AV+D+ +Y+VGG+S S +Y ++ Y P
Sbjct: 495 -SIERYDPHQNQWTVCR-PMKEPRTGVGAAVIDNYLYVVGGHSGS--SYLNTVQKYDPIS 550
Query: 597 GTWTELEG 604
TW + G
Sbjct: 551 DTWLDSAG 558
Score = 36.2 bits (82), Expect = 0.094
Identities = 25/94 (26%), Positives = 42/94 (44%), Gaps = 8/94 (8%)
Query: 324 LLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDQW 383
+ +VGG G L S ++ YD + W + M ++N+L+V+GG
Sbjct: 481 IFVVGG-HNGVSHLSS--IERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGH--- 534
Query: 384 NPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASF 417
+G N V +YDP ++W+ M R +F
Sbjct: 535 --SGSSYLNTVQKYDPISDTWLDSAGMIYCRCNF 566
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 211 bits (536), Expect = 2e-54
Identities = 165/620 (26%), Positives = 268/620 (43%), Gaps = 76/620 (12%)
Query: 14 SHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPLGGGVG 73
+H++ L + +++ CDV L A + H+ VL++ S YF ++F++
Sbjct: 163 NHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTN--------- 213
Query: 74 GQDGLGAPKDQQQPPQQQPSQQQQPPPQEEPGTPSSSPDDKLLTSPRAINNLVLQGCSSI 133
D + Q++ + P A+N+LV
Sbjct: 214 ---------DVLEAKQEEVRMEG--------------------VDPNALNSLV------- 237
Query: 134 GLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCKIA 193
+Y YT + L DT+E +L+ + +L + QV +C FL Q+ N +
Sbjct: 238 ------QYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFG 291
Query: 194 ALHGLEETKKLANKYLVE---------DVLLLNFEEMRALLDSLPPPVESELALFQMSVL 244
G E +A+KY +E + LLL E+ LL S V E +F +
Sbjct: 292 DAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQ 351
Query: 245 WLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNYHLMP 304
W+ HD + R L+ +R L+P P+L+ +++ D CQKLL++AM YHL+P
Sbjct: 352 WVGHDVQNRQGELGMLLSYIRLPLLP-PQLLADLETSSMFTGDLECQKLLMEAMKYHLLP 410
Query: 305 FRQHCRQSLASRIR-SNKKMLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPYNSA 363
R+ QS ++ R S L VGG+ + ++ YD +W + M
Sbjct: 411 ERRSMMQSPRTKPRKSTVGALYAVGGMDA---MKGTTTIEKYDLRTNSWLHIGTMNGRRL 467
Query: 364 HHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLD 423
V ++N L+V+GG D G + N V ++P W +PPM R L+
Sbjct: 468 QFGVAVIDNKLYVVGGRD-----GLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLE 522
Query: 424 KHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVHNGE 483
+Y +GG + YL++VE ++ E +W YV+S+ P + N K+Y GG
Sbjct: 523 GPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSS 582
Query: 484 YVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVM--LVEC 541
+ + +DP + W+ M+ +R +A N LY +GG+ +H + VE
Sbjct: 583 CLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVER 642
Query: 542 YDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTWTE 601
YDPKGD W+ + P+ R L D +Y+VGGY Y ++ Y ++ W E
Sbjct: 643 YDPKGDSWSTV-APLSVPRDAVAVCPLGDKLYVVGGYDGH--TYLNTVESYDAQRNEWKE 699
Query: 602 LEGDVAEPLAGPACVTVILP 621
E V AG V V LP
Sbjct: 700 -EVPVNIGRAGACVVVVKLP 718
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 210 bits (535), Expect = 3e-54
Identities = 165/611 (27%), Positives = 281/611 (45%), Gaps = 82/611 (13%)
Query: 7 RTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHP 66
RT T +P+H +N L KQL CDV + A+ + H+ VLA+CS YF ++F+
Sbjct: 24 RTITVNPAHMGKAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFT--- 80
Query: 67 PLGGGVGGQDGLGAPKDQQQPPQQQPSQQQQPPPQEEPGTPSSSPDDKLLTSPRAINNLV 126
G S S K+ I ++
Sbjct: 81 --------------------------------------GDMSESKAKKI-----EIKDVD 97
Query: 127 LQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNY 186
Q S + ++Y+YTA + ++ + V+ +L + +L + V + C FL Q+ N
Sbjct: 98 GQTLSKL-----IDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNC 152
Query: 187 KQVCKIAALHGLEETKKLANKY---------LVEDVLLLNFEEMRALLDSLPPPVESELA 237
+ A +H + + AN Y L E+ L L+ +++ +L+ S V SE
Sbjct: 153 LGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEK 212
Query: 238 LFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLDA 297
+F+ + W+ +++ETR+++ LM+ +R L+P LV+ V+ ++ + C+ L++A
Sbjct: 213 VFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEA 272
Query: 298 MNYHLMPFRQHCR-QSLASRIR---SNKKMLLLVGGLPPGPDRLPSNLVQYYDDEKKTWK 353
M YHL+P Q ++ ++ R S K++++VGG P R V+ YD E+ W
Sbjct: 273 MKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIR----SVECYDFEEDRWD 328
Query: 354 ILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQER 413
+ +P VV + ++ +GG NG V YD + W + MQER
Sbjct: 329 QIAELPSRRCRAGVVFMAGHVYAVGGF-----NGSLRVRTVDVYDGVKDQWTSIASMQER 383
Query: 414 RASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKI 473
R++ A L+ LY +GG + + L+SVE Y+ +TNEW +V+ + ++ V GK+
Sbjct: 384 RSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKL 443
Query: 474 YISGGVHNG--EYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGF 531
Y GG + + + Y+P + W DM+T+R+ + V++ +LYA GG+
Sbjct: 444 YAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHD---- 499
Query: 532 SHLDVMLVECYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTIC 591
L VE YDP + W + + R+ CAV + +Y+VGG S +S
Sbjct: 500 GPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAV-NGLLYVVGGDDGSCNL--ASVEY 556
Query: 592 YCPEKGTWTEL 602
Y P WT L
Sbjct: 557 YNPVTDKWTLL 567
Score = 52.8 bits (125), Expect = 1e-06
Identities = 41/143 (28%), Positives = 63/143 (44%), Gaps = 6/143 (4%)
Query: 324 LLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDQW 383
L VGG G R + V+ Y+ W + M + V + L+ GG D
Sbjct: 443 LYAVGGYD-GASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHD-- 499
Query: 384 NPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVEC 443
G V YDP N+W Q+ M R + C ++ LYV+GG + + L+SVE
Sbjct: 500 ---GPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEY 556
Query: 444 YNLETNEWRYVSSLPQPLAAHAG 466
YN T++W + + ++AG
Sbjct: 557 YNPVTDKWTLLPTNMSTGRSYAG 579
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 207 bits (528), Expect = 2e-53
Identities = 145/507 (28%), Positives = 240/507 (47%), Gaps = 27/507 (5%)
Query: 127 LQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNY 186
++G L +++Y YT + L D +E +LS + +L + QV + C +FL Q+ N
Sbjct: 202 MEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNC 261
Query: 187 KQVCKIAALHGLEETKKLANKYLVE---------DVLLLNFEEMRALLDSLPPPVESELA 237
+ A G + K+A+ Y +E + +LL E+ LL S + +E
Sbjct: 262 LGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEET 321
Query: 238 LFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLDA 297
+ + W+ HD E R + L+ +R L+ AP+ + +++ R D CQKL+++A
Sbjct: 322 ILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL-APQFLADMENNVLFRDDIECQKLIMEA 380
Query: 298 MNYHLMPFRQHCRQSLASRIR-SNKKMLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILT 356
M YHL+P R+ QS ++ R S L VGG+ + ++ YD W +
Sbjct: 381 MKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKG---ATSIEKYDLRTNMWTPVA 437
Query: 357 IMPYNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRAS 416
M V +++ L+V+GG D G + N V Y+P+ +W +PPM R
Sbjct: 438 NMNGRRLQFGVAVLDDKLYVVGGRD-----GLKTLNTVECYNPKTKTWSVMPPMSTHRHG 492
Query: 417 FYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYIS 476
L+ +Y +GG + YL++VE ++ + +W +V+++ P + AV +GK+Y
Sbjct: 493 LGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAV 552
Query: 477 GGVHNGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDV 536
GG + + C+DP + W M+ +R + N LYAIGG H S+L
Sbjct: 553 GGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGG-HDAPASNLTS 611
Query: 537 MLVEC---YDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYC 593
L +C YDPK D W + + + R G +L D +Y VGGY AY ++ Y
Sbjct: 612 RLSDCVERYDPKTDMWTAVASMSI-SRDAVGVCLLGDKLYAVGGYDGQ--AYLNTVEAYD 668
Query: 594 PEKGTWTELEGDVAEPLAGPACVTVIL 620
P+ WT++ + AG VTV L
Sbjct: 669 PQTNEWTQV-APLCLGRAGACVVTVKL 694
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 207 bits (528), Expect = 2e-53
Identities = 157/600 (26%), Positives = 260/600 (43%), Gaps = 75/600 (12%)
Query: 14 SHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPLGGGVG 73
+H++ L + +++ CDV L A + H+ VL++ S YF ++F++
Sbjct: 163 NHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTN--------- 213
Query: 74 GQDGLGAPKDQQQPPQQQPSQQQQPPPQEEPGTPSSSPDDKLLTSPRAINNLVLQGCSSI 133
D + Q++ + P A+N+LV
Sbjct: 214 ---------DVLEAKQEEVRMEG--------------------VDPNALNSLV------- 237
Query: 134 GLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCKIA 193
+Y YT + L DT+E +L+ + +L + QV +C FL Q+ N +
Sbjct: 238 ------QYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFG 291
Query: 194 ALHGLEETKKLANKYLVE---------DVLLLNFEEMRALLDSLPPPVESELALFQMSVL 244
G E +A+KY +E + LLL E+ LL S V E +F +
Sbjct: 292 DAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQ 351
Query: 245 WLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNYHLMP 304
W+ HD + R L+ +R L+P P+L+ +++ D CQKLL++AM YHL+P
Sbjct: 352 WVGHDVQNRQGELGMLLSYIRLPLLP-PQLLADLETSSMFTGDLECQKLLMEAMKYHLLP 410
Query: 305 FRQHCRQSLASRIR-SNKKMLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPYNSA 363
R+ QS ++ R S L VGG+ + ++ YD +W + M
Sbjct: 411 ERRSMMQSPRTKPRKSTVGALYAVGGMDA---MKGTTTIEKYDLRTNSWLHIGTMNGRRL 467
Query: 364 HHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLD 423
V ++N L+V+GG D G + N V ++P W +PPM R L+
Sbjct: 468 QFGVAVIDNKLYVVGGRD-----GLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLE 522
Query: 424 KHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVHNGE 483
+Y +GG + YL++VE ++ E +W YV+S+ P + N K+Y GG
Sbjct: 523 GPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSS 582
Query: 484 YVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVM--LVEC 541
+ + +DP + W+ M+ +R +A N LY +GG+ +H + VE
Sbjct: 583 CLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVER 642
Query: 542 YDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTWTE 601
YDPKGD W+ + P+ R L D +Y+VGGY Y ++ Y ++ W E
Sbjct: 643 YDPKGDSWSTV-APLSVPRDAVAVCPLGDKLYVVGGYDGH--TYLNTVESYDAQRNEWKE 699
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 206 bits (525), Expect = 4e-53
Identities = 137/481 (28%), Positives = 241/481 (50%), Gaps = 31/481 (6%)
Query: 135 LRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCKIAA 194
LR++++Y+YTA + ++ + V+ +L + +L + V K C +FL Q+ N + A
Sbjct: 19 LRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFAD 78
Query: 195 LHGLEETKKLANKY---------LVEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLW 245
+H + AN Y L E+ L L E++ +L+ S + SE +F+ + W
Sbjct: 79 MHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAW 138
Query: 246 LEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNYHLMPF 305
+ HD++ R ++ LM+ +R L+P LV+RV+ ++ C+ L++AM YHL+P
Sbjct: 139 VNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPT 198
Query: 306 RQH-CRQSLASRIRSN---KKMLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPYN 361
Q +S+ +R+R+ K++++VGG P R V+ YD +++ W + +P
Sbjct: 199 EQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIR----SVECYDFKEERWHQVAELPSR 254
Query: 362 SAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYACR 421
+V + +F +GG NG V YDP + W + M++RR++ A
Sbjct: 255 RCRAGMVYMAGLVFAVGGF-----NGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAV 309
Query: 422 LDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVHN 481
L+ LY +GG + + LSSVE YN+++NEW +V+ + ++ V G +Y GG
Sbjct: 310 LNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDG 369
Query: 482 G--EYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLV 539
+ + + CY+ + W +M+T+R+ + V+N+ LYA+GG+ L V
Sbjct: 370 ASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHD----GPLVRKSV 425
Query: 540 ECYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTW 599
E YDP + W + + R+ CAV + +Y+VGG S +S Y P W
Sbjct: 426 EVYDPTTNAWRQVADMNMCRRNAGVCAV-NGLLYVVGGDDGSCNL--ASVEYYNPTTDKW 482
Query: 600 T 600
T
Sbjct: 483 T 483
Score = 63.9 bits (154), Expect = 4e-10
Identities = 45/144 (31%), Positives = 67/144 (46%), Gaps = 6/144 (4%)
Query: 323 MLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDQ 382
+L VGG G R + V+ Y+ W + M + V + N L+ +GG D
Sbjct: 360 LLYAVGGYD-GASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHD- 417
Query: 383 WNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVE 442
G V YDP N+W Q+ M R + C ++ LYV+GG + + L+SVE
Sbjct: 418 ----GPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVE 473
Query: 443 CYNLETNEWRYVSSLPQPLAAHAG 466
YN T++W VSS ++AG
Sbjct: 474 YYNPTTDKWTVVSSCMSTGRSYAG 497
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 206 bits (525), Expect = 4e-53
Identities = 137/481 (28%), Positives = 241/481 (50%), Gaps = 31/481 (6%)
Query: 135 LRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCKIAA 194
LR++++Y+YTA + ++ + V+ +L + +L + V K C +FL Q+ N + A
Sbjct: 111 LRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFAD 170
Query: 195 LHGLEETKKLANKY---------LVEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLW 245
+H + AN Y L E+ L L E++ +L+ S + SE +F+ + W
Sbjct: 171 MHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAW 230
Query: 246 LEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNYHLMPF 305
+ HD++ R ++ LM+ +R L+P LV+RV+ ++ C+ L++AM YHL+P
Sbjct: 231 VNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPT 290
Query: 306 RQH-CRQSLASRIRSN---KKMLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPYN 361
Q +S+ +R+R+ K++++VGG P R V+ YD +++ W + +P
Sbjct: 291 EQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIR----SVECYDFKEERWHQVAELPSR 346
Query: 362 SAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYACR 421
+V + +F +GG NG V YDP + W + M++RR++ A
Sbjct: 347 RCRAGMVYMAGLVFAVGGF-----NGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAV 401
Query: 422 LDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVHN 481
L+ LY +GG + + LSSVE YN+++NEW +V+ + ++ V G +Y GG
Sbjct: 402 LNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDG 461
Query: 482 G--EYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLV 539
+ + + CY+ + W +M+T+R+ + V+N+ LYA+GG+ L V
Sbjct: 462 ASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHD----GPLVRKSV 517
Query: 540 ECYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTW 599
E YDP + W + + R+ CAV + +Y+VGG S +S Y P W
Sbjct: 518 EVYDPTTNAWRQVADMNMCRRNAGVCAV-NGLLYVVGGDDGSCNL--ASVEYYNPTTDKW 574
Query: 600 T 600
T
Sbjct: 575 T 575
Score = 63.9 bits (154), Expect = 4e-10
Identities = 45/144 (31%), Positives = 67/144 (46%), Gaps = 6/144 (4%)
Query: 323 MLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDQ 382
+L VGG G R + V+ Y+ W + M + V + N L+ +GG D
Sbjct: 452 LLYAVGGYD-GASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHD- 509
Query: 383 WNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVE 442
G V YDP N+W Q+ M R + C ++ LYV+GG + + L+SVE
Sbjct: 510 ----GPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVE 565
Query: 443 CYNLETNEWRYVSSLPQPLAAHAG 466
YN T++W VSS ++AG
Sbjct: 566 YYNPTTDKWTVVSSCMSTGRSYAG 589
Score = 47.0 bits (110), Expect = 5e-05
Identities = 20/54 (37%), Positives = 31/54 (57%)
Query: 10 TFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS 63
T +P H +N L + L CDVT+ A+ + H+ VLA+CS YF ++F+
Sbjct: 37 TVNPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFT 90
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 206 bits (525), Expect = 4e-53
Identities = 137/481 (28%), Positives = 241/481 (50%), Gaps = 31/481 (6%)
Query: 135 LRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCKIAA 194
LR++++Y+YTA + ++ + V+ +L + +L + V K C +FL Q+ N + A
Sbjct: 107 LRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFAD 166
Query: 195 LHGLEETKKLANKY---------LVEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLW 245
+H + AN Y L E+ L L E++ +L+ S + SE +F+ + W
Sbjct: 167 MHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAW 226
Query: 246 LEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNYHLMPF 305
+ HD++ R ++ LM+ +R L+P LV+RV+ ++ C+ L++AM YHL+P
Sbjct: 227 VNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPT 286
Query: 306 RQH-CRQSLASRIRSN---KKMLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPYN 361
Q +S+ +R+R+ K++++VGG P R V+ YD +++ W + +P
Sbjct: 287 EQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIR----SVECYDFKEERWHQVAELPSR 342
Query: 362 SAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYACR 421
+V + +F +GG NG V YDP + W + M++RR++ A
Sbjct: 343 RCRAGMVYMAGLVFAVGGF-----NGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAV 397
Query: 422 LDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVHN 481
L+ LY +GG + + LSSVE YN+++NEW +V+ + ++ V G +Y GG
Sbjct: 398 LNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDG 457
Query: 482 G--EYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLV 539
+ + + CY+ + W +M+T+R+ + V+N+ LYA+GG+ L V
Sbjct: 458 ASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHD----GPLVRKSV 513
Query: 540 ECYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTW 599
E YDP + W + + R+ CAV + +Y+VGG S +S Y P W
Sbjct: 514 EVYDPTTNAWRQVADMNMCRRNAGVCAV-NGLLYVVGGDDGSCNL--ASVEYYNPTTDKW 570
Query: 600 T 600
T
Sbjct: 571 T 571
Score = 63.9 bits (154), Expect = 4e-10
Identities = 45/144 (31%), Positives = 67/144 (46%), Gaps = 6/144 (4%)
Query: 323 MLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDQ 382
+L VGG G R + V+ Y+ W + M + V + N L+ +GG D
Sbjct: 448 LLYAVGGYD-GASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHD- 505
Query: 383 WNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVE 442
G V YDP N+W Q+ M R + C ++ LYV+GG + + L+SVE
Sbjct: 506 ----GPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVE 561
Query: 443 CYNLETNEWRYVSSLPQPLAAHAG 466
YN T++W VSS ++AG
Sbjct: 562 YYNPTTDKWTVVSSCMSTGRSYAG 585
Score = 47.0 bits (110), Expect = 5e-05
Identities = 20/54 (37%), Positives = 31/54 (57%)
Query: 10 TFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS 63
T +P H +N L + L CDVT+ A+ + H+ VLA+CS YF ++F+
Sbjct: 33 TVNPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFT 86
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 187 bits (476), Expect = 2e-47
Identities = 150/585 (25%), Positives = 244/585 (41%), Gaps = 77/585 (13%)
Query: 28 RKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPLGGGVGGQDGLGAPKDQQQP 87
R+ CDVTL +F H+ VLA+ YF ++F++ D +
Sbjct: 33 RQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTN------------------DMMEC 74
Query: 88 PQQQPSQQQQPPPQEEPGTPSSSPDDKLLTSPRAINNLVLQGCSSIGLRLVLEYLYTANV 147
Q + +V+QG L ++ + Y N+
Sbjct: 75 KQDE---------------------------------IVMQGMDPSALEALINFAYNGNL 101
Query: 148 TLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCKIAALHGLEETKKLANK 207
+ V+ +L + L + + C FL +++ +N V + A AN
Sbjct: 102 AIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFAETMMCAVLYDAANS 161
Query: 208 YL---------VEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAP 258
++ E+ L L E++ L+ V+SE +F+ ++ W+ +DRE R Y P
Sbjct: 162 FIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRGPYLP 221
Query: 259 DLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNYHLMPFRQHCRQSLASRIR 318
+L+ +R L L +RVQ D +R C+ L+ +A +YHLMP R+ + +R R
Sbjct: 222 ELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMPERRPHLPAFRTRPR 281
Query: 319 ---SNKKMLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPYNSAHHCVVEVENFLF 375
S ++ VGGL D L N+V+ +D W+ M + V V L+
Sbjct: 282 CCTSIAGLIYAVGGLNSAGDSL--NVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLY 339
Query: 376 VLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLDKHLYVIGGRNET 435
+GG D G+ + V Y+P ++W ++ M +R++ LD +YV GG +
Sbjct: 340 AIGGYD-----GQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGN 394
Query: 436 GYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVHNGEYVPWLYCYDPVM 495
LSSVE Y+ ET++W V+S+ +A V G+IY+SGG + + Y+
Sbjct: 395 SSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHT 454
Query: 496 DVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLVECYDPKGDQWNILQTP 555
W M KR H A + +++ GG GF + + E Y DQW ++ P
Sbjct: 455 ATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGF----LSIAEMYSSVADQWCLI-VP 509
Query: 556 ILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTWT 600
+ RS +Y VGGY SS Y PE WT
Sbjct: 510 MHTRRSRVSLVASCGRLYAVGGYDGQSNL--SSVEMYDPETDCWT 552
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 187 bits (475), Expect = 3e-47
Identities = 146/599 (24%), Positives = 264/599 (44%), Gaps = 78/599 (13%)
Query: 14 SHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPLGGGVG 73
+H+ ++L+ +N L + CDVTL + + F H+ VLA+CS YF ++F+S
Sbjct: 14 THAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSE-------- 65
Query: 74 GQDGLGAPKDQQQPPQQQPSQQQQPPPQEEPGTPSSSPDDKLLTSPRAINNLVLQGCSSI 133
E G P +QG ++
Sbjct: 66 ---------------------------LSEKGKPYVD----------------IQGLTAS 82
Query: 134 GLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCKIA 193
+ ++L+++YT V ++++ V+E+L + +L + V + C +FL Q+ N + A
Sbjct: 83 TMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNCLGIRDFA 142
Query: 194 ALHGLEETKKLANKYLV---------EDVLLLNFEEMRALLDSLPPPVESELALFQMSVL 244
H + + A + E+ +LL+ E+ L+ V+SE +F+ +
Sbjct: 143 ETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEEPVFEAVIN 202
Query: 245 WLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNYHLMP 304
W++H ++ R + P+L++ +R L+ + + + + F+R C+ L+ +A +HL P
Sbjct: 203 WVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDEAKKFHLRP 262
Query: 305 FRQHCRQSLASRIRSN-KKMLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPYNSA 363
+ Q +R R ++LL+VGG G + P ++V+ YD + + W L +
Sbjct: 263 ELRSQMQGPRTRARLGANEVLLVVGGF--GSQQSPIDVVEKYDPKTQEWSFLPSITRKRR 320
Query: 364 HHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNS---WIQLPPMQERRASFYAC 420
+ V + + ++V+GG D G+ + V D + W + PM RR A
Sbjct: 321 YVASVSLHDRIYVIGGYD-----GRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGAT 375
Query: 421 RLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVH 480
L +YV GG + + +S+E Y+ ++W + + V +G IY GG
Sbjct: 376 TLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYD 435
Query: 481 NGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLVE 540
+ + YDP W M TKR+ +A++ND +Y +GG G +HL VE
Sbjct: 436 GLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGG--FDGTAHLS--SVE 491
Query: 541 CYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTW 599
Y+ + D W + T + R G VL +Y + GY + + SS CY P +W
Sbjct: 492 AYNIRTDSWTTV-TSMTTPRCYVGATVLRGRLYAIAGYDGN--SLLSSIECYDPIIDSW 547
Score = 100 bits (248), Expect = 5e-21
Identities = 53/178 (29%), Positives = 84/178 (47%), Gaps = 5/178 (2%)
Query: 342 VQYYDDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRF 401
++ YD W +L M +V ++ LGG D G + N V +YDP
Sbjct: 396 MERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYD-----GLNILNSVEKYDPHT 450
Query: 402 NSWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPL 461
W + PM +R+ L+ H+YV+GG + T +LSSVE YN+ T+ W V+S+ P
Sbjct: 451 GHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPR 510
Query: 462 AAHAGAVHNGKIYISGGVHNGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDR 519
V G++Y G + + CYDP++D W M T+R + V+ ++
Sbjct: 511 CYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQRCDAGVCVLREK 568
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 186 bits (471), Expect = 7e-47
Identities = 151/623 (24%), Positives = 259/623 (41%), Gaps = 113/623 (18%)
Query: 1 MSRSGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRS 60
+SR G + H + ++ + ++ L CD+ L ++ HK VLASCS YF +
Sbjct: 60 LSREGHSVAHNSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHA 119
Query: 61 LFSSHPPLGGGVGGQDGLGAPKDQQQPPQQQPSQQQQPPPQEEPGTPSSSPDDKLLTSPR 120
+F++ + S+Q + P+
Sbjct: 120 MFTN------------------------EMSESRQTHVTLHD--------------IDPQ 141
Query: 121 AINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQ 180
A++ LV ++ YTA + + V+ +L + +L + V C +FL Q
Sbjct: 142 ALDQLV-------------QFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQ 188
Query: 181 ISVQNYKQVCKIAALHGLEETKKLANKYLV---------EDVLLLNFEEMRALLDSLPPP 231
+ N + A H + K A++Y++ E+ +LL +++ L+ S
Sbjct: 189 LDPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLN 248
Query: 232 VESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQ 291
V SE +++ + W++HD + R Q+ P LMK +R L+ L+ V + +R P C+
Sbjct: 249 VPSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCK 308
Query: 292 KLLLDAMNYHLMPFRQHCRQSLASRIRSNK---KMLLLVGGLPPGPDRLPSNLVQYYDDE 348
LL++A+ +HL+P ++ + +R R + +L VGG G + YD
Sbjct: 309 DLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGG---GSLFAIHGDCEAYDTR 365
Query: 349 KKTWKILTIMPYNSAHHCVVEVENFLFVLGGED----------------QWNP------- 385
W ++ M A V V N L+ +GG D W P
Sbjct: 366 TDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTR 425
Query: 386 -------------------NGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLDKHL 426
+G N RYDP +W + M RR LD +L
Sbjct: 426 RSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNL 485
Query: 427 YVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVHNGEYVP 486
Y +GG + + +L++VE Y + N W V+S+ ++ AV G +Y++GG +
Sbjct: 486 YAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLN 545
Query: 487 WLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLVECYDPKG 546
+ Y P W MN +R+ H L M+ LYA+GGN G S L+ +E Y+P+
Sbjct: 546 SVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGN--DGSSSLN--SIEKYNPRT 601
Query: 547 DQWNILQTPILEGRSGPGCAVLD 569
++W + + + RS G AVL+
Sbjct: 602 NKW-VAASCMFTRRSSVGVAVLE 623
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 185 bits (469), Expect = 1e-46
Identities = 145/598 (24%), Positives = 261/598 (43%), Gaps = 79/598 (13%)
Query: 15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPLGGGVGG 74
H L +NLL + + CDV L ++ + H+ +L++CS YFR++F+
Sbjct: 50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTG---------- 99
Query: 75 QDGLGAPKDQQQPPQQQPSQQQQPPPQEEPGTPSSSPDDKLLTSPRAINNLVLQGCSSIG 134
+ S+Q + +V++
Sbjct: 100 --------------ELAESRQTE---------------------------VVIRDIDERA 118
Query: 135 LRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCKIAA 194
+ L++++ YT+ +T+ V+ +L + +L + ++ + C +FL Q+ N + A
Sbjct: 119 MELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFAD 178
Query: 195 LHGLEETKKLANKYL---------VEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLW 245
H E ++A+K+ E+ +LL ++ ++ S V SE +F + W
Sbjct: 179 THSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAW 238
Query: 246 LEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNYHLMPF 305
+++ + R P +++ +R L+ LV V S +++D C+ L+ +A NY L+P
Sbjct: 239 VKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNYLLLPQ 298
Query: 306 RQHCRQSLASRIRSN---KKMLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPYNS 362
+ Q +R R ++L VGG G D + S V+ YD + W+++ M
Sbjct: 299 ERPLMQGPRTRPRKPIRCGEVLFAVGGWCSG-DAISS--VERYDPQTNEWRMVASMSKRR 355
Query: 363 AHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSW-IQLPPMQERRASFYACR 421
V +++ L+ +GG D G N V RYDP+ N W + P R S
Sbjct: 356 CGVGVSVLDDLLYAVGGHD-----GSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVAV 410
Query: 422 LDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVHN 481
L LY +GG++ L+ VE Y+ + N+W V+S+ A AV G +Y GG
Sbjct: 411 LGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDG 470
Query: 482 GEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLVEC 541
+ + Y+P + W M T+R AV D +YA+GG ++ E
Sbjct: 471 TSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRD----DTTELSSAER 526
Query: 542 YDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTW 599
Y+P+ +QW+ + + RSG G AV++ + VGG+ + Y + + P+ TW
Sbjct: 527 YNPRTNQWSPV-VAMTSRRSGVGLAVVNGQLMAVGGFDGT--TYLKTIEVFDPDANTW 581
Score = 90.1 bits (222), Expect = 5e-18
Identities = 52/169 (30%), Positives = 79/169 (46%), Gaps = 5/169 (2%)
Query: 340 NLVQYYDDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDP 399
N+V+ YD ++ W + M V + FL+ +GG D +P N V RY+P
Sbjct: 428 NIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSP-----LNTVERYNP 482
Query: 400 RFNSWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQ 459
+ N W + PM RR +Y +GGR++T LSS E YN TN+W V ++
Sbjct: 483 QENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTS 542
Query: 460 PLAAHAGAVHNGKIYISGGVHNGEYVPWLYCYDPVMDVWARKQDMNTKR 508
+ AV NG++ GG Y+ + +DP + W MN +R
Sbjct: 543 RRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRR 591
>gi|11545731 gigaxonin [Homo sapiens]
Length = 597
Score = 170 bits (430), Expect = 4e-42
Identities = 147/637 (23%), Positives = 258/637 (40%), Gaps = 92/637 (14%)
Query: 12 DPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPLGGG 71
DP H+ LL L+ + FCD L G++ K +LA+ S Y R+ + +PP G
Sbjct: 9 DPQHAARLLRALSSFREESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDG 68
Query: 72 VGGQDGLGAPKDQQQPPQQQPSQQQQPPPQEEPGTPSSSPDDKLLTSPRAINNLVLQGCS 131
+ + L+G S
Sbjct: 69 -------------------------------------------------STYKIELEGIS 79
Query: 132 SIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCK 191
+ +R +L+Y+++ + L+ DT+++V+ + +L + + LC +FL I+ +N +
Sbjct: 80 VMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIGIRD 139
Query: 192 IAALHGLEETKKLANKYL---------VEDVLLLNFEEMRALLDSLPPPVESELALFQMS 242
A + L LA +YL E+ L L+ ++++ ++ V +E +F+
Sbjct: 140 FALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAV 199
Query: 243 VLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNYHL 302
+ W+ HD E R + D+M L + + + L E+ M +P+ ++++ + N L
Sbjct: 200 IRWIAHDTEIRKVHMKDVMSALWVSGLDSSYLREQ------MLNEPLVREIVKECSNIPL 253
Query: 303 MPFRQHCRQSLASRIRSNKKMLLLVGG---LPPGPDRLPSNLVQYYDDEKKTWKILTIMP 359
+Q + R + ++ VGG + P + YD ++ W L +
Sbjct: 254 SQPQQGEAMLANFKPRGYSECIVTVGGEERVSRKPTAAMRCMCPLYDPNRQLWIELAPLS 313
Query: 360 YNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYA 419
+H V+ E FLFV GG+D+ K + + +YDP N+W LPPM E R +F
Sbjct: 314 MPRINHGVLSAEGFLFVFGGQDE----NKQTLSSGEKYDPDANTWTALPPMNEARHNFGI 369
Query: 420 CRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISGGV 479
+D LY++GG + L S+ECY++ + W L A KIY GG
Sbjct: 370 VEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMKKKIYAMGGG 429
Query: 480 HNGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLV 539
G+ + CYDP W + +R + LY GG + + M+
Sbjct: 430 SYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGGVRSREDAQGSEMVT 489
Query: 540 ---ECYDPKGDQWNIL--QTPILEGRSG--PGCAVLDDSIYLVG------GYSWSMGAYK 586
E Y + +W L Q + S G + SIY++G Y + + +K
Sbjct: 490 CKSEFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGDLDTGTNYDY-VREFK 548
Query: 587 SSTICYCPEKGTWTELEGDVAEPLAGPACVTVILPSC 623
ST GTW + + L C + + +C
Sbjct: 549 RST-------GTWHHTKPLLPSDLRRTGCAALRIANC 578
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 168 bits (425), Expect = 2e-41
Identities = 119/489 (24%), Positives = 230/489 (47%), Gaps = 32/489 (6%)
Query: 127 LQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNY 186
+ G S ++L++EY YT V ++ D VE++L+ + +I + + C +FL ++ + N
Sbjct: 82 IPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNC 141
Query: 187 KQVCKIAALHGLEETKKLANKYLVE----------DVLLLNFEEMRALLDSLPPPVESEL 236
+CK + E ++ A +++ + L L+ E++ +++ V+ E
Sbjct: 142 IGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQED 201
Query: 237 ALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLD 296
A+F+ + W+ HD + R Q+ L+ ++R AL+ A + V+ D+++ C+ ++++
Sbjct: 202 AVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIIN 261
Query: 297 AMN--YHLM---PFRQHCRQSLASRIRSNKKMLLLVGGLPPGPDRLPSNLVQYYDDEKKT 351
A+ Y L P L +R R +L +GG G P+N ++ YD
Sbjct: 262 ALKAMYDLNMNGPSNSDFTNPL-TRPRLPYAILFAIGGWSGGS---PTNAIEAYDARADR 317
Query: 352 WKILTIMPYN-SAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPM 410
W +T + A+H ++ +++++GG D + N V R+DP +W Q+ PM
Sbjct: 318 WVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVD-----YFNSVKRFDPVKKTWHQVAPM 372
Query: 411 QERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHN 470
RR L +Y +GG + L++ E Y ETN+W ++ + + + +
Sbjct: 373 HSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLY 432
Query: 471 GKIYISGGVHNGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKG 530
GK+YI GG + E + Y+ + W M ++R+ + + +YA+GG G
Sbjct: 433 GKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGG--FDG 490
Query: 531 FSHLDVMLVECYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTI 590
+ L E Y P + W + T + RS G V+DD +++VGG++ + +
Sbjct: 491 ANRL--RSAEAYSPVANTWRTIPT-MFNPRSNFGIEVVDDLLFVVGGFNGFTTTF--NVE 545
Query: 591 CYCPEKGTW 599
CY + W
Sbjct: 546 CYDEKTDEW 554
Score = 67.0 bits (162), Expect = 5e-11
Identities = 40/177 (22%), Positives = 72/177 (40%), Gaps = 5/177 (2%)
Query: 340 NLVQYYDDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDP 399
N + Y+ E W ++ M + + +++ GG NG Y+
Sbjct: 401 NTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGF-----NGNECLFTAEVYNT 455
Query: 400 RFNSWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQ 459
N W + PM+ RR+ +H+Y +GG + L S E Y+ N WR + ++
Sbjct: 456 ESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFN 515
Query: 460 PLAAHAGAVHNGKIYISGGVHNGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVM 516
P + V + +++ GG + + CYD D W DM+ R+ + V+
Sbjct: 516 PRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVV 572
>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 875
Score = 162 bits (410), Expect = 9e-40
Identities = 144/607 (23%), Positives = 251/607 (41%), Gaps = 77/607 (12%)
Query: 12 DPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPLGGG 71
DP H +L LN R + F D+ + +G++F H+ VLASCS YF+ L G
Sbjct: 308 DPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQ-DSG 366
Query: 72 VGGQDGLGAPKDQQQPPQQQPSQQQQPPPQEEPGTPSSSPDDKLLTSPRAINNLVLQGCS 131
GG++ L LVL
Sbjct: 367 QGGREKL---------------------------------------------ELVLSNLQ 381
Query: 132 SIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCK 191
+ L L+LE++YT ++ + + +L + K+CV FL Q++ N V
Sbjct: 382 ADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGVLA 441
Query: 192 IAALHGLEETKKLANKYLV---------EDVLLLNFEEMRALLDSLPPPVESELALFQMS 242
+A E +A + + E++L ++ ++ A + + ++E +++
Sbjct: 442 MAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETV 501
Query: 243 VLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNYHL 302
+ W++ D TR QYA +L+ +R I L+ V + + +++ C+ L+ +A YH+
Sbjct: 502 IKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHM 561
Query: 303 MPFRQHCRQSLASRIRSNK---KMLLLVGGLPP-GPDRLPSNLVQYYDDEKKTWKILTIM 358
+P + Q+ +R R + ++++LVGG G + V ++ + W L +
Sbjct: 562 LPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASL 621
Query: 359 P-YNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASF 417
P Y+ VV + +++ GG + +G + V Y ++W + M R
Sbjct: 622 PFYDREFFSVVSAGDNIYLSGGME----SGVTLAD-VWCYMSLLDNWNLVSRMTVPRCRH 676
Query: 418 YACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISG 477
+ D +Y +GG G + VE Y+ TN+W V+ LP+ + + A V GKIY+ G
Sbjct: 677 NSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFG 736
Query: 478 GVHN-GEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDV 536
GV+ G L Y P + W+ + +N ++ +GG + +
Sbjct: 737 GVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGGAYARA------ 790
Query: 537 MLVECYDPKGDQWNILQTPIL-EGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPE 595
YDP ++ NI P + R VLD IY GG S G + Y P
Sbjct: 791 --TTIYDP--EKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPT 846
Query: 596 KGTWTEL 602
TWT L
Sbjct: 847 TNTWTLL 853
Score = 76.3 bits (186), Expect = 8e-14
Identities = 54/194 (27%), Positives = 88/194 (45%), Gaps = 11/194 (5%)
Query: 426 LYVIGGRNETGY----LSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNG-KIYISGGVH 480
+ ++GGR G L +V C+N + N+W ++SLP V G IY+SGG+
Sbjct: 586 IVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGME 645
Query: 481 NGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLVE 540
+G + ++CY ++D W M R H V + ++Y +GG + G +V VE
Sbjct: 646 SGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAG----NVDHVE 701
Query: 541 CYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTWT 600
YD +QW + P+ + V IY+ GG + G Y P+ TW+
Sbjct: 702 RYDTITNQWEAV-APLPKAVHSAAATVCGGKIYVFGGVN-EAGRAAGVLQSYVPQTNTWS 759
Query: 601 ELEGDVAEPLAGPA 614
+E + + PA
Sbjct: 760 FIESPMIDNKYAPA 773
Score = 46.6 bits (109), Expect = 7e-05
Identities = 37/142 (26%), Positives = 57/142 (40%), Gaps = 13/142 (9%)
Query: 339 SNLVQYYDDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYD 398
+ ++Q Y + TW + ++ + V + F+F+LGG + YD
Sbjct: 745 AGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGGA---------YARATTIYD 795
Query: 399 PRFNSWIQLPPMQERRASFYACRLDKHLYVIGG--RNETGYLSSVECYNLETNEWRYVSS 456
P + P M R A LD +Y GG +E L ++E Y TN W +
Sbjct: 796 PEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTWTLLPH 855
Query: 457 LPQPLAAHAGAVHNGKIYISGG 478
+P P+ H V K YI G
Sbjct: 856 MPCPVFRHGCVVI--KKYIQSG 875
>gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain
containing 9 [Homo sapiens]
Length = 875
Score = 162 bits (410), Expect = 9e-40
Identities = 144/607 (23%), Positives = 251/607 (41%), Gaps = 77/607 (12%)
Query: 12 DPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPLGGG 71
DP H +L LN R + F D+ + +G++F H+ VLASCS YF+ L G
Sbjct: 308 DPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQ-DSG 366
Query: 72 VGGQDGLGAPKDQQQPPQQQPSQQQQPPPQEEPGTPSSSPDDKLLTSPRAINNLVLQGCS 131
GG++ L LVL
Sbjct: 367 QGGREKL---------------------------------------------ELVLSNLQ 381
Query: 132 SIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCK 191
+ L L+LE++YT ++ + + +L + K+CV FL Q++ N V
Sbjct: 382 ADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGVLA 441
Query: 192 IAALHGLEETKKLANKYLV---------EDVLLLNFEEMRALLDSLPPPVESELALFQMS 242
+A E +A + + E++L ++ ++ A + + ++E +++
Sbjct: 442 MAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETV 501
Query: 243 VLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNYHL 302
+ W++ D TR QYA +L+ +R I L+ V + + +++ C+ L+ +A YH+
Sbjct: 502 IKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHM 561
Query: 303 MPFRQHCRQSLASRIRSNK---KMLLLVGGLPP-GPDRLPSNLVQYYDDEKKTWKILTIM 358
+P + Q+ +R R + ++++LVGG G + V ++ + W L +
Sbjct: 562 LPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASL 621
Query: 359 P-YNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASF 417
P Y+ VV + +++ GG + +G + V Y ++W + M R
Sbjct: 622 PFYDREFFSVVSAGDNIYLSGGME----SGVTLAD-VWCYMSLLDNWNLVSRMTVPRCRH 676
Query: 418 YACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISG 477
+ D +Y +GG G + VE Y+ TN+W V+ LP+ + + A V GKIY+ G
Sbjct: 677 NSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFG 736
Query: 478 GVHN-GEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDV 536
GV+ G L Y P + W+ + +N ++ +GG + +
Sbjct: 737 GVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGGAYARA------ 790
Query: 537 MLVECYDPKGDQWNILQTPIL-EGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPE 595
YDP ++ NI P + R VLD IY GG S G + Y P
Sbjct: 791 --TTIYDP--EKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPT 846
Query: 596 KGTWTEL 602
TWT L
Sbjct: 847 TNTWTLL 853
Score = 76.3 bits (186), Expect = 8e-14
Identities = 54/194 (27%), Positives = 88/194 (45%), Gaps = 11/194 (5%)
Query: 426 LYVIGGRNETGY----LSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNG-KIYISGGVH 480
+ ++GGR G L +V C+N + N+W ++SLP V G IY+SGG+
Sbjct: 586 IVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGME 645
Query: 481 NGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLVE 540
+G + ++CY ++D W M R H V + ++Y +GG + G +V VE
Sbjct: 646 SGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAG----NVDHVE 701
Query: 541 CYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTWT 600
YD +QW + P+ + V IY+ GG + G Y P+ TW+
Sbjct: 702 RYDTITNQWEAV-APLPKAVHSAAATVCGGKIYVFGGVN-EAGRAAGVLQSYVPQTNTWS 759
Query: 601 ELEGDVAEPLAGPA 614
+E + + PA
Sbjct: 760 FIESPMIDNKYAPA 773
Score = 46.6 bits (109), Expect = 7e-05
Identities = 37/142 (26%), Positives = 57/142 (40%), Gaps = 13/142 (9%)
Query: 339 SNLVQYYDDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYD 398
+ ++Q Y + TW + ++ + V + F+F+LGG + YD
Sbjct: 745 AGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGGA---------YARATTIYD 795
Query: 399 PRFNSWIQLPPMQERRASFYACRLDKHLYVIGG--RNETGYLSSVECYNLETNEWRYVSS 456
P + P M R A LD +Y GG +E L ++E Y TN W +
Sbjct: 796 PEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTWTLLPH 855
Query: 457 LPQPLAAHAGAVHNGKIYISGG 478
+P P+ H V K YI G
Sbjct: 856 MPCPVFRHGCVVI--KKYIQSG 875
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 154 bits (390), Expect = 2e-37
Identities = 115/489 (23%), Positives = 218/489 (44%), Gaps = 30/489 (6%)
Query: 138 VLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCKIAALHG 197
+++++Y++ +TL++D V+ +L + IL + V + C +++ N V A H
Sbjct: 121 LVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHN 180
Query: 198 LEETKKLANKYLV---------EDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEH 248
+ +A++Y ED + ++ + + LL S +E+E ++ ++ WL
Sbjct: 181 RIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLA 240
Query: 249 DRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNYHLMPFRQH 308
+ + ++ + + ++R L+P L+ V ++ + C+ LL +A NYHL
Sbjct: 241 NPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLH-LSSR 299
Query: 309 CRQSLASRIRSNKK-----MLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPYNSA 363
IR+ + +L VGG D P ++ Y K +W M
Sbjct: 300 AVPDFEYSIRTTPRKHTAGVLFCVGGRGGSGD--PFRSIECYSINKNSWFFGPEMNSRRR 357
Query: 364 HHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLD 423
H V+ VE ++ +GG D G + +DP N W+ M +R L
Sbjct: 358 HVGVISVEGKVYAVGGHD-----GNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLG 412
Query: 424 KHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVHNGE 483
+Y IGG ++ + VE Y++E+++W V+ + P +Y GG
Sbjct: 413 GPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMA 472
Query: 484 YVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLVECYD 543
+ + YDP +D W ++M +RA + ++ ++ LY +GG + + VE YD
Sbjct: 473 SLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFD----DNSPLSSVERYD 528
Query: 544 PKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTWTELE 603
P+ ++W+ + + R G G A + I+ VGG++ + AY ++ + P W EL
Sbjct: 529 PRSNKWDYV-AALTTPRGGVGIATVMGKIFAVGGHNGN--AYLNTVEAFDPVLNRW-ELV 584
Query: 604 GDVAEPLAG 612
G V+ AG
Sbjct: 585 GSVSHCRAG 593
Score = 36.6 bits (83), Expect = 0.072
Identities = 22/70 (31%), Positives = 30/70 (42%), Gaps = 11/70 (15%)
Query: 6 DRTSTFDPSHSDNLLHGLNLLWR-----------KQLFCDVTLTAQGQQFHCHKAVLASC 54
+R+S D D+ + N W+ CDVTL + CHK VLA
Sbjct: 29 NRSSISDGDGEDSFIFEANEAWKDFHGSLLRFYENGELCDVTLKVGSKLISCHKLVLACV 88
Query: 55 SQYFRSLFSS 64
YFR++F S
Sbjct: 89 IPYFRAMFLS 98
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.427
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,155,722
Number of Sequences: 37866
Number of extensions: 1413956
Number of successful extensions: 13292
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 300
Number of HSP's successfully gapped in prelim test: 160
Number of HSP's that attempted gapping in prelim test: 9043
Number of HSP's gapped (non-prelim): 2579
length of query: 628
length of database: 18,247,518
effective HSP length: 108
effective length of query: 520
effective length of database: 14,157,990
effective search space: 7362154800
effective search space used: 7362154800
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.