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Search of human proteins with 53831991
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|53831991 steryl-sulfatase precursor [Homo sapiens]
(583 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|53831991 steryl-sulfatase precursor [Homo sapiens] 1216 0.0
gi|157266309 arylsulfatase E precursor [Homo sapiens] 603 e-172
gi|58743319 arylsulfatase family, member H [Homo sapiens] 602 e-172
gi|71852584 arylsulfatase D isoform a precursor [Homo sapiens] 587 e-167
gi|31742482 arylsulfatase F precursor [Homo sapiens] 561 e-160
gi|71852586 arylsulfatase D isoform b precursor [Homo sapiens] 299 4e-81
gi|4503899 galactosamine (N-acetyl)-6-sulfate sulfatase precurso... 155 7e-38
gi|146229331 arylsulfatase A isoform a precursor [Homo sapiens] 147 3e-35
gi|146229329 arylsulfatase A isoform a precursor [Homo sapiens] 147 3e-35
gi|146229327 arylsulfatase A isoform b [Homo sapiens] 147 3e-35
gi|146229324 arylsulfatase A isoform a precursor [Homo sapiens] 147 3e-35
gi|6005990 arylsulfatase A isoform a precursor [Homo sapiens] 147 3e-35
gi|45430057 Arylsulfatase G [Homo sapiens] 123 5e-28
gi|38569407 arylsulfatase B isoform 2 precursor [Homo sapiens] 105 9e-23
gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens] 105 9e-23
gi|109389362 arylsulfatase J [Homo sapiens] 99 1e-20
gi|59797060 arylsulfatase family, member I [Homo sapiens] 92 1e-18
gi|4557659 iduronate-2-sulfatase isoform a precursor [Homo sapiens] 91 2e-18
gi|5360208 iduronate-2-sulfatase isoform b precursor [Homo sapiens] 86 7e-17
gi|4504061 glucosamine (N-acetyl)-6-sulfatase precursor [Homo sa... 61 3e-09
gi|39930577 arylsulfatase K [Homo sapiens] 57 5e-08
gi|189571643 sulfatase 1 [Homo sapiens] 55 2e-07
gi|189571641 sulfatase 1 [Homo sapiens] 55 2e-07
gi|189571638 sulfatase 1 [Homo sapiens] 55 2e-07
gi|189571636 sulfatase 1 [Homo sapiens] 55 2e-07
gi|240255483 sulfatase 2 isoform a precursor [Homo sapiens] 54 4e-07
gi|240255478 sulfatase 2 isoform b precursor [Homo sapiens] 54 4e-07
gi|29789100 sulfatase 2 isoform a precursor [Homo sapiens] 54 4e-07
gi|4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo sap... 53 9e-07
gi|169217295 PREDICTED: similar to iduronate 2-sulfatase (Hunter... 45 2e-04
>gi|53831991 steryl-sulfatase precursor [Homo sapiens]
Length = 583
Score = 1216 bits (3147), Expect = 0.0
Identities = 583/583 (100%), Positives = 583/583 (100%)
Query: 1 MPLRKMKIPFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLAS 60
MPLRKMKIPFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLAS
Sbjct: 1 MPLRKMKIPFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLAS 60
Query: 61 GGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAK 120
GGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAK
Sbjct: 61 GGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAK 120
Query: 121 LLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTT 180
LLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTT
Sbjct: 121 LLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTT 180
Query: 181 GFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPL 240
GFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPL
Sbjct: 181 GFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPL 240
Query: 241 NCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFA 300
NCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFA
Sbjct: 241 NCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFA 300
Query: 301 GKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGS 360
GKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGS
Sbjct: 301 GKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGS 360
Query: 361 NGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRI 420
NGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRI
Sbjct: 361 NGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRI 420
Query: 421 IDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNG 480
IDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNG
Sbjct: 421 IDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNG 480
Query: 481 CFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQT 540
CFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQT
Sbjct: 481 CFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQT 540
Query: 541 LPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDKRLSR 583
LPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDKRLSR
Sbjct: 541 LPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDKRLSR 583
>gi|157266309 arylsulfatase E precursor [Homo sapiens]
Length = 589
Score = 603 bits (1554), Expect = e-172
Identities = 300/556 (53%), Positives = 385/556 (69%), Gaps = 7/556 (1%)
Query: 23 AASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAF 82
+ASRPNI+L+MADDLGIGD GCYGN T+RTPNIDRLA GVKLTQH++A+ LCTPSRAAF
Sbjct: 34 SASRPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAF 93
Query: 83 MTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCH 142
+TGRYPVRSGM S V +T +SGGLPT+E TFAK+LK++GY+T LIGKWHLG++C
Sbjct: 94 LTGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKILKEKGYATGLIGKWHLGLNCE 153
Query: 143 SKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAA 202
S +D CHHPLHHGF++FYG+ + + DC E S ++ + Q++ + LTL A
Sbjct: 154 SASDHCHHPLHHGFDHFYGMPFSLMGDCARWELSEKRVNLEQKLNFLFQVLALVALTLVA 213
Query: 203 LNCLGLLHVP-LGVFFSLLFLAALILT-LFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNL 260
L+ V + V +S L L+ + F+G L +CF+MRN+ I +QPM +
Sbjct: 214 GKLTHLIPVSWMPVIWSALSAVLLLASSYFVGALIVHA--DCFLMRNHTITEQPMCFQRT 271
Query: 261 TQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVG 320
T + E A F++RN PFLL +S+LHVH L + ++F GKS HG+YGD VEEMDW VG
Sbjct: 272 TPLILQEVASFLKRNKHGPFLLFVSFLHVHIPLITMENFLGKSLHGLYGDNVEEMDWMVG 331
Query: 321 QILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKA-NNWEGGIRVP 379
+IL+ LD L+N TLIYFTSD G +E + +GG NGIYKGGK WEGGIRVP
Sbjct: 332 RILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQ-YGGWNGIYKGGKGMGGWEGGIRVP 390
Query: 380 GILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDH 439
GI RWP V+ AG+ I EPTS MD+FPTV +LAG +P+DR+IDG+DL+PLL G +Q SDH
Sbjct: 391 GIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLLPLLLGTAQHSDH 450
Query: 440 EFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDP 499
EFL HYC +L+A RWH ++ ++WK F TP F P G+ C+ VC CFG V HHDP
Sbjct: 451 EFLMHYCERFLHAARWHQRDRGTMWKVHFVTPVFQPEGAGACYGRKVCPCFGEKVVHHDP 510
Query: 500 PLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWL 559
PLLFD+S+DP E + LTPASEP FY++++ +Q+A H +TL VP Q +W+PWL
Sbjct: 511 PLLFDLSRDPSETHILTPASEPVFYQVMERVQQAVWEHQRTLSPVPLQLDRLGNIWRPWL 570
Query: 560 QLCCPSTGLSCQCDRE 575
Q CC L C C RE
Sbjct: 571 QPCCGPFPL-CWCLRE 585
>gi|58743319 arylsulfatase family, member H [Homo sapiens]
Length = 562
Score = 602 bits (1552), Expect = e-172
Identities = 299/557 (53%), Positives = 381/557 (68%), Gaps = 13/557 (2%)
Query: 25 SRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMT 84
+RPNI+L+MADDLG+GD CYGN ++ TPNIDRLAS GV+LTQHLAA+ +CTPSRAAF+T
Sbjct: 5 ARPNIVLLMADDLGVGDLCCYGNNSVSTPNIDRLASEGVRLTQHLAAASMCTPSRAAFLT 64
Query: 85 GRYPVRSGMAS-WSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHS 143
GRYP+RSGM S ++ F + SGGLPT+E TFAKLL+ +GY T LIGKWHLG+SC S
Sbjct: 65 GRYPIRSGMVSAYNLNRAFTWLGGSGGLPTNETTFAKLLQHRGYRTGLIGKWHLGLSCAS 124
Query: 144 KTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAAL 203
+ D C+HPL+HGF+YFYG+ L DC+ + T R + + L I V L + L
Sbjct: 125 RNDHCYHPLNHGFHYFYGVPFGLLSDCQASK----TPELHRWLRIKLWISTVALALVPFL 180
Query: 204 NCLGLL----HVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDN 259
+ VP V F LA L T + + R NC +MRN+EIIQQPM +
Sbjct: 181 LLIPKFARWFSVPWKVIFVFALLAFLFFTSWYSSYGFTRRWNCILMRNHEIIQQPMKEEK 240
Query: 260 LTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSV 319
+ + EA FI+R PFLL S+LHVHT L S K F G+S++G YGD VEEMDW V
Sbjct: 241 VASLMLKEALAFIERYKREPFLLFFSFLHVHTPLISKKKFVGRSKYGRYGDNVEEMDWMV 300
Query: 320 GQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKA-NNWEGGIRV 378
G+IL+ LD+ RLAN TL+YFTSD G H+E + ++ GG NGIYKGGK WEGGIRV
Sbjct: 301 GKILDALDQERLANHTLVYFTSDNGGHLEPLDGAVQL-GGWNGIYKGGKGMGGWEGGIRV 359
Query: 379 PGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSD 438
PGI RWP V++AG+ I+EPTS MDI+PT++ + G L +DR+IDG++LMPLLEG++ SD
Sbjct: 360 PGIFRWPSVLEAGRVINEPTSLMDIYPTLSYIGGGILSQDRVIDGQNLMPLLEGRASHSD 419
Query: 439 HEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHD 498
HEFLFHYC YL+ VRWH ++ ++WKA + TP F P G+ C+ + +C C G VT+HD
Sbjct: 420 HEFLFHYCGVYLHTVRWHQKDCATVWKAHYVTPKFYPEGTGACYGSGICSCSGD-VTYHD 478
Query: 499 PPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPW 558
PPLLFDIS+DP E PL P +EP F ++K M+ A H +TL VP QFS N +WKPW
Sbjct: 479 PPLLFDISRDPSEALPLNPDNEPLFDSVIKKMEAAIREHRRTLTPVPQQFSVFNTIWKPW 538
Query: 559 LQLCCPSTGLSCQCDRE 575
LQ CC T C CD+E
Sbjct: 539 LQPCC-GTFPFCGCDKE 554
>gi|71852584 arylsulfatase D isoform a precursor [Homo sapiens]
Length = 593
Score = 587 bits (1512), Expect = e-167
Identities = 282/567 (49%), Positives = 367/567 (64%), Gaps = 6/567 (1%)
Query: 2 PLRKMKIPFLLLFFLW----EAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDR 57
P + +P LL L E ++ A +PNI+L+MADDLG GD GCYGN T+RTPNID+
Sbjct: 12 PAARDSLPVLLFLCLLLKTCEPKTANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQ 71
Query: 58 LASGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEIT 117
LA GV+LTQHLAA+PLCTPSRAAF+TGR+ RSGM + + + A SGGLP +E T
Sbjct: 72 LAEEGVRLTQHLAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETT 131
Query: 118 FAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSV 177
FA++L+ GY+T LIGKWH G++C S+ D CHHPL+HGF+YFYG+ T DC PG
Sbjct: 132 FARILQQHGYATGLIGKWHQGVNCASRGDHCHHPLNHGFDYFYGMPFTLTNDCDPGRPPE 191
Query: 178 FTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYF 237
+ ++ Q + + +LTLAA G V + + L + +
Sbjct: 192 VDAALRAQLWGYTQFLALGILTLAAGQTCGFFSVSARAVTGMAGVGCLFFISWYSSFGFV 251
Query: 238 RPLNCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSK 297
R NC +MRN+++ +QPM + + EA +I+R+ PFLL LS LHVH L ++
Sbjct: 252 RRWNCILMRNHDVTEQPMVLEKTASLMLKEAVSYIERHKHGPFLLFLSLLHVHIPLVTTS 311
Query: 298 DFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIH 357
F GKSQHG+YGD VEEMDW +G++LN +++ L N T YFTSD G H+E ++
Sbjct: 312 AFLGKSQHGLYGDNVEEMDWLIGKVLNAIEDNGLKNSTFTYFTSDHGGHLEARDGHSQL- 370
Query: 358 GGSNGIYKGGKA-NNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLP 416
GG NGIYKGGK WEGGIRVPGI WP V+ AG+ I EPTS MD+FPTV +L G +P
Sbjct: 371 GGWNGIYKGGKGMGGWEGGIRVPGIFHWPGVLPAGRVIGEPTSLMDVFPTVVQLVGGEVP 430
Query: 417 EDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPV 476
+DR+IDG L+PLL+G RS HEFLFHYC +L+A RWH ++S S+WK + TP F+P
Sbjct: 431 QDRVIDGHSLVPLLQGAEARSAHEFLFHYCGQHLHAARWHQKDSGSVWKVHYTTPQFHPE 490
Query: 477 GSNGCFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADR 536
G+ C+ VC C G VTHH PPLLFD+S+DP E PLTP SEP ++ ++ + A
Sbjct: 491 GAGACYGRGVCPCSGEGVTHHRPPLLFDLSRDPSEARPLTPDSEPLYHAVIARVGAAVSE 550
Query: 537 HTQTLPEVPDQFSWNNFLWKPWLQLCC 563
H QTL VP QFS +N LWKPWLQ CC
Sbjct: 551 HRQTLSPVPQQFSMSNILWKPWLQPCC 577
>gi|31742482 arylsulfatase F precursor [Homo sapiens]
Length = 590
Score = 561 bits (1445), Expect = e-160
Identities = 284/582 (48%), Positives = 384/582 (65%), Gaps = 11/582 (1%)
Query: 2 PLRKMKIPFLLLFFLWEAESHAA--SRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLA 59
P R + L+ L ++H +PNI+L+M DDLGIGD GCYGN T+RTP+IDRLA
Sbjct: 3 PRRPLVFMSLVCALLNTCQAHRVHDDKPNIVLIMVDDLGIGDLGCYGNDTMRTPHIDRLA 62
Query: 60 SGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFA 119
GV+LTQH++A+ LC+PSR+AF+TGRYP+RSGM S V A GLP +E T A
Sbjct: 63 REGVRLTQHISAASLCSPSRSAFLTGRYPIRSGMVSSGNRRVIQNLAVPAGLPLNETTLA 122
Query: 120 KLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFT 179
LLK QGYST LIGKWH G++C S++D CHHP ++GF+Y+YG+ T + C P
Sbjct: 123 ALLKKQGYSTGLIGKWHQGLNCDSRSDQCHHPYNYGFDYYYGMPFTLVDSCWPDPSRNTE 182
Query: 180 TGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRP 239
F+ ++L +Q+V + +LTL G + VP + FS++ + L + F + P
Sbjct: 183 LAFESQLWLCVQLVAIAILTLTFGKLSGWVSVPWLLIFSMILF--IFLLGYAWFSSHTSP 240
Query: 240 L--NCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSK 297
L +C +MR +EI +QPM + + EA F++R+++ FLL S+LHVHT L ++
Sbjct: 241 LYWDCLLMRGHEITEQPMKAERAGSIMVKEAISFLERHSKETFLLFFSFLHVHTPLPTTD 300
Query: 298 DFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIH 357
DF G S+HG+YGD VEEMD VG+IL+ +D+ L N+TL+YFTSD G H+E ++
Sbjct: 301 DFTGTSKHGLYGDNVEEMDSMVGKILDAIDDFGLRNNTLVYFTSDHGGHLEARRGHAQL- 359
Query: 358 GGSNGIYKGGKA-NNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLP 416
GG NGIYKGGK WEGGIRVPGI+RWP + AG+ I EPTS MDI PTVA ++G LP
Sbjct: 360 GGWNGIYKGGKGMGGWEGGIRVPGIVRWPGKVPAGRLIKEPTSLMDILPTVASVSGGSLP 419
Query: 417 EDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQ-NSTSIWKAFFFTPNFNP 475
+DR+IDGRDLMPLL+G + S+HEFLFHYC +YL+AVRW P+ +S S+WKA + TP F P
Sbjct: 420 QDRVIDGRDLMPLLQGNVRHSEHEFLFHYCGSYLHAVRWIPKDDSGSVWKAHYVTPVFQP 479
Query: 476 VGSNGCFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAAD 535
S GC+ T +C CFG VT+H+PPLLFD+S+DP E PLTPA+EP ++K + A
Sbjct: 480 PASGGCYVTSLCRCFGEQVTYHNPPLLFDLSRDPSESTPLTPATEPLHDFVIKKVANALK 539
Query: 536 RHTQTLPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQ 577
H +T+ V Q S N + WL+ CC C CD+E++
Sbjct: 540 EHQETIVPVTYQLSELN-QGRTWLKPCC-GVFPFCLCDKEEE 579
>gi|71852586 arylsulfatase D isoform b precursor [Homo sapiens]
Length = 382
Score = 299 bits (766), Expect = 4e-81
Identities = 149/322 (46%), Positives = 200/322 (62%), Gaps = 4/322 (1%)
Query: 2 PLRKMKIPFLLLFFLW----EAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDR 57
P + +P LL L E ++ A +PNI+L+MADDLG GD GCYGN T+RTPNID+
Sbjct: 12 PAARDSLPVLLFLCLLLKTCEPKTANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQ 71
Query: 58 LASGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEIT 117
LA GV+LTQHLAA+PLCTPSRAAF+TGR+ RSGM + + + A SGGLP +E T
Sbjct: 72 LAEEGVRLTQHLAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETT 131
Query: 118 FAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSV 177
FA++L+ GY+T LIGKWH G++C S+ D CHHPL+HGF+YFYG+ T DC PG
Sbjct: 132 FARILQQHGYATGLIGKWHQGVNCASRGDHCHHPLNHGFDYFYGMPFTLTNDCDPGRPPE 191
Query: 178 FTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYF 237
+ ++ Q + + +LTLAA G V + + L + +
Sbjct: 192 VDAALRAQLWGYTQFLALGILTLAAGQTCGFFSVSARAVTGMAGVGCLFFISWYSSFGFV 251
Query: 238 RPLNCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSK 297
R NC +MRN+++ +QPM + + EA +I+R+ PFLL LS LHVH L ++
Sbjct: 252 RRWNCILMRNHDVTEQPMVLEKTASLMLKEAVSYIERHKHGPFLLFLSLLHVHIPLVTTS 311
Query: 298 DFAGKSQHGVYGDAVEEMDWSV 319
F GKSQHG+YGD VEEMDW +
Sbjct: 312 AFLGKSQHGLYGDNVEEMDWLI 333
>gi|4503899 galactosamine (N-acetyl)-6-sulfate sulfatase precursor
[Homo sapiens]
Length = 522
Score = 155 bits (393), Expect = 7e-38
Identities = 111/316 (35%), Positives = 156/316 (49%), Gaps = 21/316 (6%)
Query: 259 NLTQRLTVEAAQFIQRNTET-PFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDW 317
NLTQ EA FI+R PF L + H +++SK F G SQ G YGDAV E+D
Sbjct: 204 NLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDD 263
Query: 318 SVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIR 377
S+G+IL LL +L +A++T ++FTSD GA + + GGSNG + GK +EGG+R
Sbjct: 264 SIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQ----GGSNGPFLCGKQTTFEGGMR 319
Query: 378 VPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMP-LLEGKSQR 436
P + WP + AGQ + S MD+F T LAG P DR IDG +L+P LL+G+
Sbjct: 320 EPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRLMD 379
Query: 437 SDHEFLFHY-----CNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFG 491
+F+Y A L + H T+ W+ F +F P + TH
Sbjct: 380 RP---IFYYRGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTTH------ 430
Query: 492 SYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWN 551
+ H PL+F + +DP ER PL+ AS + E L + +H + L Q +
Sbjct: 431 NLEDHTKLPLIFHLGRDPGERFPLSFAS-AEYQEALSRITSVVQQHQEALVPAQPQLNVC 489
Query: 552 NFLWKPWLQLCCPSTG 567
N+ W C G
Sbjct: 490 NWAVMNWAPPGCEKLG 505
Score = 117 bits (292), Expect = 4e-26
Identities = 60/143 (41%), Positives = 87/143 (60%), Gaps = 8/143 (5%)
Query: 21 SHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRA 80
S A PNI+L++ DD+G GD G YG + TPN+DR+A+ G+ +A+PLC+PSRA
Sbjct: 25 SGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRA 84
Query: 81 AFMTGRYPVRSGMASWSRTGVFLFTASS--GGLPTDEITFAKLLKDQGYSTALIGKWHLG 138
A +TGR P+R+G + + +T GG+P E +LLK GY + ++GKWHLG
Sbjct: 85 ALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLG 144
Query: 139 MSCHSKTDFCHHPLHHGFNYFYG 161
+ F HPL HGF+ ++G
Sbjct: 145 ----HRPQF--HPLKHGFDEWFG 161
>gi|146229331 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 147 bits (370), Expect = 3e-35
Identities = 107/325 (32%), Positives = 159/325 (48%), Gaps = 21/325 (6%)
Query: 244 MMRNYEIIQQPMSYDNLTQRLTVEAAQFIQ--RNTETPFLLVLSYLHVHTALFSSKDFAG 301
++ N + QP L R A + + + PF L + H H FS + FA
Sbjct: 181 LLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAE 240
Query: 302 KSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSN 361
+S G +GD++ E+D +VG ++ + +L L +TL+ FT+D G +S GG +
Sbjct: 241 RSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMS-----RGGCS 295
Query: 362 GIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRII 421
G+ + GK +EGG+R P + WP I G E S++D+ PT+A LAGAPLP + +
Sbjct: 296 GLLRCGKGTTYEGGVREPALAFWPGHIAPG-VTHELASSLDLLPTLAALAGAPLP-NVTL 353
Query: 422 DGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGC 481
DG DL PLL G + +S + LF Y +Y + VR T +KA FFT +
Sbjct: 354 DGFDLSPLLLG-TGKSPRQSLFFY-PSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTAD 411
Query: 482 FATHVCFCFGSYVTHHDPPLLFDISKDPRERNPL---TPASEPRFYEILKVMQEAADRHT 538
A H S +T H+PPLL+D+SKDP E L + P + LK +Q +
Sbjct: 412 PACHA----SSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLD 467
Query: 539 QTLPEVPDQFSWNNFLWKPWLQLCC 563
+ P Q + P LQ+CC
Sbjct: 468 AAVTFGPSQVARGE---DPALQICC 489
Score = 130 bits (328), Expect = 3e-30
Identities = 69/139 (49%), Positives = 89/139 (64%), Gaps = 9/139 (6%)
Query: 24 ASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFM 83
A PNI+L+ ADDLG GD GCYG+ + TPN+D+LA+GG++ T LCTPSRAA +
Sbjct: 18 ARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALL 77
Query: 84 TGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHS 143
TGR PVR GM GV L +S GGLP +E+T A++L +GY T + GKWHLG+
Sbjct: 78 TGRLPVRMGM----YPGV-LVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVG--- 129
Query: 144 KTDFCHHPLHHGFNYFYGI 162
+ P H GF+ F GI
Sbjct: 130 -PEGAFLPPHQGFHRFLGI 147
>gi|146229329 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 147 bits (370), Expect = 3e-35
Identities = 107/325 (32%), Positives = 159/325 (48%), Gaps = 21/325 (6%)
Query: 244 MMRNYEIIQQPMSYDNLTQRLTVEAAQFIQ--RNTETPFLLVLSYLHVHTALFSSKDFAG 301
++ N + QP L R A + + + PF L + H H FS + FA
Sbjct: 181 LLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAE 240
Query: 302 KSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSN 361
+S G +GD++ E+D +VG ++ + +L L +TL+ FT+D G +S GG +
Sbjct: 241 RSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMS-----RGGCS 295
Query: 362 GIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRII 421
G+ + GK +EGG+R P + WP I G E S++D+ PT+A LAGAPLP + +
Sbjct: 296 GLLRCGKGTTYEGGVREPALAFWPGHIAPG-VTHELASSLDLLPTLAALAGAPLP-NVTL 353
Query: 422 DGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGC 481
DG DL PLL G + +S + LF Y +Y + VR T +KA FFT +
Sbjct: 354 DGFDLSPLLLG-TGKSPRQSLFFY-PSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTAD 411
Query: 482 FATHVCFCFGSYVTHHDPPLLFDISKDPRERNPL---TPASEPRFYEILKVMQEAADRHT 538
A H S +T H+PPLL+D+SKDP E L + P + LK +Q +
Sbjct: 412 PACHA----SSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLD 467
Query: 539 QTLPEVPDQFSWNNFLWKPWLQLCC 563
+ P Q + P LQ+CC
Sbjct: 468 AAVTFGPSQVARGE---DPALQICC 489
Score = 130 bits (328), Expect = 3e-30
Identities = 69/139 (49%), Positives = 89/139 (64%), Gaps = 9/139 (6%)
Query: 24 ASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFM 83
A PNI+L+ ADDLG GD GCYG+ + TPN+D+LA+GG++ T LCTPSRAA +
Sbjct: 18 ARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALL 77
Query: 84 TGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHS 143
TGR PVR GM GV L +S GGLP +E+T A++L +GY T + GKWHLG+
Sbjct: 78 TGRLPVRMGM----YPGV-LVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVG--- 129
Query: 144 KTDFCHHPLHHGFNYFYGI 162
+ P H GF+ F GI
Sbjct: 130 -PEGAFLPPHQGFHRFLGI 147
>gi|146229327 arylsulfatase A isoform b [Homo sapiens]
Length = 423
Score = 147 bits (370), Expect = 3e-35
Identities = 107/325 (32%), Positives = 159/325 (48%), Gaps = 21/325 (6%)
Query: 244 MMRNYEIIQQPMSYDNLTQRLTVEAAQFIQ--RNTETPFLLVLSYLHVHTALFSSKDFAG 301
++ N + QP L R A + + + PF L + H H FS + FA
Sbjct: 97 LLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAE 156
Query: 302 KSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSN 361
+S G +GD++ E+D +VG ++ + +L L +TL+ FT+D G +S GG +
Sbjct: 157 RSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMS-----RGGCS 211
Query: 362 GIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRII 421
G+ + GK +EGG+R P + WP I G E S++D+ PT+A LAGAPLP + +
Sbjct: 212 GLLRCGKGTTYEGGVREPALAFWPGHIAPG-VTHELASSLDLLPTLAALAGAPLP-NVTL 269
Query: 422 DGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGC 481
DG DL PLL G + +S + LF Y +Y + VR T +KA FFT +
Sbjct: 270 DGFDLSPLLLG-TGKSPRQSLFFY-PSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTAD 327
Query: 482 FATHVCFCFGSYVTHHDPPLLFDISKDPRERNPL---TPASEPRFYEILKVMQEAADRHT 538
A H S +T H+PPLL+D+SKDP E L + P + LK +Q +
Sbjct: 328 PACHA----SSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLD 383
Query: 539 QTLPEVPDQFSWNNFLWKPWLQLCC 563
+ P Q + P LQ+CC
Sbjct: 384 AAVTFGPSQVARGE---DPALQICC 405
Score = 52.8 bits (125), Expect = 9e-07
Identities = 26/60 (43%), Positives = 36/60 (60%), Gaps = 4/60 (6%)
Query: 103 LFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGI 162
L +S GGLP +E+T A++L +GY T + GKWHLG+ + P H GF+ F GI
Sbjct: 8 LVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVG----PEGAFLPPHQGFHRFLGI 63
>gi|146229324 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 147 bits (370), Expect = 3e-35
Identities = 107/325 (32%), Positives = 159/325 (48%), Gaps = 21/325 (6%)
Query: 244 MMRNYEIIQQPMSYDNLTQRLTVEAAQFIQ--RNTETPFLLVLSYLHVHTALFSSKDFAG 301
++ N + QP L R A + + + PF L + H H FS + FA
Sbjct: 181 LLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAE 240
Query: 302 KSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSN 361
+S G +GD++ E+D +VG ++ + +L L +TL+ FT+D G +S GG +
Sbjct: 241 RSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMS-----RGGCS 295
Query: 362 GIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRII 421
G+ + GK +EGG+R P + WP I G E S++D+ PT+A LAGAPLP + +
Sbjct: 296 GLLRCGKGTTYEGGVREPALAFWPGHIAPG-VTHELASSLDLLPTLAALAGAPLP-NVTL 353
Query: 422 DGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGC 481
DG DL PLL G + +S + LF Y +Y + VR T +KA FFT +
Sbjct: 354 DGFDLSPLLLG-TGKSPRQSLFFY-PSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTAD 411
Query: 482 FATHVCFCFGSYVTHHDPPLLFDISKDPRERNPL---TPASEPRFYEILKVMQEAADRHT 538
A H S +T H+PPLL+D+SKDP E L + P + LK +Q +
Sbjct: 412 PACHA----SSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLD 467
Query: 539 QTLPEVPDQFSWNNFLWKPWLQLCC 563
+ P Q + P LQ+CC
Sbjct: 468 AAVTFGPSQVARGE---DPALQICC 489
Score = 130 bits (328), Expect = 3e-30
Identities = 69/139 (49%), Positives = 89/139 (64%), Gaps = 9/139 (6%)
Query: 24 ASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFM 83
A PNI+L+ ADDLG GD GCYG+ + TPN+D+LA+GG++ T LCTPSRAA +
Sbjct: 18 ARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALL 77
Query: 84 TGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHS 143
TGR PVR GM GV L +S GGLP +E+T A++L +GY T + GKWHLG+
Sbjct: 78 TGRLPVRMGM----YPGV-LVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVG--- 129
Query: 144 KTDFCHHPLHHGFNYFYGI 162
+ P H GF+ F GI
Sbjct: 130 -PEGAFLPPHQGFHRFLGI 147
>gi|6005990 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 147 bits (370), Expect = 3e-35
Identities = 107/325 (32%), Positives = 159/325 (48%), Gaps = 21/325 (6%)
Query: 244 MMRNYEIIQQPMSYDNLTQRLTVEAAQFIQ--RNTETPFLLVLSYLHVHTALFSSKDFAG 301
++ N + QP L R A + + + PF L + H H FS + FA
Sbjct: 181 LLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAE 240
Query: 302 KSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSN 361
+S G +GD++ E+D +VG ++ + +L L +TL+ FT+D G +S GG +
Sbjct: 241 RSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMS-----RGGCS 295
Query: 362 GIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRII 421
G+ + GK +EGG+R P + WP I G E S++D+ PT+A LAGAPLP + +
Sbjct: 296 GLLRCGKGTTYEGGVREPALAFWPGHIAPG-VTHELASSLDLLPTLAALAGAPLP-NVTL 353
Query: 422 DGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGC 481
DG DL PLL G + +S + LF Y +Y + VR T +KA FFT +
Sbjct: 354 DGFDLSPLLLG-TGKSPRQSLFFY-PSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTAD 411
Query: 482 FATHVCFCFGSYVTHHDPPLLFDISKDPRERNPL---TPASEPRFYEILKVMQEAADRHT 538
A H S +T H+PPLL+D+SKDP E L + P + LK +Q +
Sbjct: 412 PACHA----SSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLD 467
Query: 539 QTLPEVPDQFSWNNFLWKPWLQLCC 563
+ P Q + P LQ+CC
Sbjct: 468 AAVTFGPSQVARGE---DPALQICC 489
Score = 130 bits (328), Expect = 3e-30
Identities = 69/139 (49%), Positives = 89/139 (64%), Gaps = 9/139 (6%)
Query: 24 ASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFM 83
A PNI+L+ ADDLG GD GCYG+ + TPN+D+LA+GG++ T LCTPSRAA +
Sbjct: 18 ARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALL 77
Query: 84 TGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHS 143
TGR PVR GM GV L +S GGLP +E+T A++L +GY T + GKWHLG+
Sbjct: 78 TGRLPVRMGM----YPGV-LVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVG--- 129
Query: 144 KTDFCHHPLHHGFNYFYGI 162
+ P H GF+ F GI
Sbjct: 130 -PEGAFLPPHQGFHRFLGI 147
>gi|45430057 Arylsulfatase G [Homo sapiens]
Length = 525
Score = 123 bits (308), Expect = 5e-28
Identities = 100/338 (29%), Positives = 152/338 (44%), Gaps = 27/338 (7%)
Query: 244 MMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTET--PFLLVLSYLHVHTALFSSKDFAG 301
+ N I++QP++ +L Q+ +A QFIQR + + PFLL ++ H+H L ++ A
Sbjct: 203 LYENLNIVEQPVNLSSLAQKYAEKATQFIQRASTSGRPFLLYVALAHMHVPLPVTQLPAA 262
Query: 302 KSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSN 361
+YG + EMD VGQI + +D + +T ++FT D G ++ G + G
Sbjct: 263 PRGRSLYGAGLWEMDSLVGQIKDKVDHT-VKENTFLWFTGDNGPWAQKCELAGSV-GPFT 320
Query: 362 GIYK---GG---KANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPL 415
G ++ GG K WEGG RVP + WP + S +DIFPTV LA A L
Sbjct: 321 GFWQTRQGGSPAKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAQASL 380
Query: 416 PEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNP 475
P+ R DG D+ +L G+SQ H LFH + +KAF+ T
Sbjct: 381 PQGRRFDGVDVSEVLFGRSQ-PGHRVLFHPNSGAAGEFGALQTVRLERYKAFYITG---- 435
Query: 476 VGSNGCFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAAD 535
G+ C + H PL+F++ D E PL E E V+ E
Sbjct: 436 -GARACDGS------TGPELQHKFPLIFNLEDDTAEAVPL----ERGGAEYQAVLPEVRK 484
Query: 536 RHTQTLPEVP-DQFSWNNFLWKPWLQLCCPSTGLSCQC 572
L ++ D S ++ P + CC ++C+C
Sbjct: 485 VLADVLQDIANDNISSADYTQDPSVTPCCNPYQIACRC 522
Score = 110 bits (274), Expect = 5e-24
Identities = 60/150 (40%), Positives = 90/150 (60%), Gaps = 12/150 (8%)
Query: 26 RPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTG 85
+PN ++++ADD+G GD G +T T N+D++AS G++ AA+ C+PSRA+ +TG
Sbjct: 35 KPNFVIILADDMGWGDLGANWAETKDTANLDKMASEGMRFVDFHAAASTCSPSRASLLTG 94
Query: 86 RYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKT 145
R +R+G+ T F T S GGLP +E T A++L+ GY T +IGKWHLG H
Sbjct: 95 RLGLRNGV-----TRNFAVT-SVGGLPLNETTLAEVLQQAGYVTGIIGKWHLGH--HGS- 145
Query: 146 DFCHHPLHHGFNYFYGISLTNLRDCKPGEG 175
+HP GF+Y++GI ++ C G
Sbjct: 146 ---YHPNFRGFDYYFGIPYSHDMGCTDTPG 172
>gi|38569407 arylsulfatase B isoform 2 precursor [Homo sapiens]
Length = 413
Score = 105 bits (263), Expect = 9e-23
Identities = 65/159 (40%), Positives = 95/159 (59%), Gaps = 14/159 (8%)
Query: 8 IPFLLLFFLWEAESHA-ASRP-NIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKL 65
+P LLL L S A ASRP +++ ++ADDLG D G +G++ IRTP++D LA+GGV L
Sbjct: 24 LPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGSR-IRTPHLDALAAGGVLL 82
Query: 66 TQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQ 125
+ PLCTPSR+ +TGRY +R+G+ ++ +P DE +LLK+
Sbjct: 83 DNYYT-QPLCTPSRSQLLTGRYQIRTGLQHQ-----IIWPCQPSCVPLDEKLLPQLLKEA 136
Query: 126 GYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISL 164
GY+T ++GKWHLGM + K P GF+ ++G L
Sbjct: 137 GYTTHMVGKWHLGM--YRKECL---PTRRGFDTYFGYLL 170
Score = 62.0 bits (149), Expect = 1e-09
Identities = 52/190 (27%), Positives = 78/190 (41%), Gaps = 14/190 (7%)
Query: 277 ETPFLLVLSYLHVHTAL------FSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELR 330
E P L L+ VH L DF Y V MD +VG + L
Sbjct: 229 EKPLFLYLALQSVHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSG 288
Query: 331 LANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQA 390
L N+T+ F++D G + GG+N +G K + WEGG+R G + P + Q
Sbjct: 289 LWNNTVFIFSTDNGGQT--------LAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQK 340
Query: 391 GQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYL 450
G K E D PT+ KLA + +DG D+ + S E L + ++
Sbjct: 341 GVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFV 400
Query: 451 NAVRWHPQNS 460
++ + P+ S
Sbjct: 401 DSSPYWPECS 410
>gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens]
Length = 533
Score = 105 bits (263), Expect = 9e-23
Identities = 65/159 (40%), Positives = 95/159 (59%), Gaps = 14/159 (8%)
Query: 8 IPFLLLFFLWEAESHA-ASRP-NIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKL 65
+P LLL L S A ASRP +++ ++ADDLG D G +G++ IRTP++D LA+GGV L
Sbjct: 24 LPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGSR-IRTPHLDALAAGGVLL 82
Query: 66 TQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQ 125
+ PLCTPSR+ +TGRY +R+G+ ++ +P DE +LLK+
Sbjct: 83 DNYYT-QPLCTPSRSQLLTGRYQIRTGLQHQ-----IIWPCQPSCVPLDEKLLPQLLKEA 136
Query: 126 GYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISL 164
GY+T ++GKWHLGM + K P GF+ ++G L
Sbjct: 137 GYTTHMVGKWHLGM--YRKECL---PTRRGFDTYFGYLL 170
Score = 67.8 bits (164), Expect = 3e-11
Identities = 77/321 (23%), Positives = 121/321 (37%), Gaps = 54/321 (16%)
Query: 277 ETPFLLVLSYLHVHTAL------FSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELR 330
E P L L+ VH L DF Y V MD +VG + L
Sbjct: 229 EKPLFLYLALQSVHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSG 288
Query: 331 LANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQA 390
L N+T+ F++D G + GG+N +G K + WEGG+R G + P + Q
Sbjct: 289 LWNNTVFIFSTDNGGQT--------LAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQK 340
Query: 391 GQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYL 450
G K E D PT+ KLA + +DG D+ + S E L + ++
Sbjct: 341 GVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFV 400
Query: 451 NAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSY----------------- 493
++ P+NS + K P ++ + + H G++
Sbjct: 401 DSSPC-PRNSMAPAKDDSSLPEYSAFNT----SVHAAIRHGNWKLLTGYPGCGYWFPPPS 455
Query: 494 ------VTHHDPPL----LFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLP- 542
+ DPP LFDI +DP ER+ L S + + K++ H ++P
Sbjct: 456 QYNVSEIPSSDPPTKTLWLFDIDRDPEERHDL---SREYPHIVTKLLSRLQFYHKHSVPV 512
Query: 543 ----EVPDQFSWNNFLWKPWL 559
+ P +W PW+
Sbjct: 513 YFPAQDPRCDPKATGVWGPWM 533
>gi|109389362 arylsulfatase J [Homo sapiens]
Length = 599
Score = 98.6 bits (244), Expect = 1e-20
Identities = 54/144 (37%), Positives = 84/144 (58%), Gaps = 12/144 (8%)
Query: 18 EAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTP 77
E + + S+P++I ++ADD G D G +G++ I+TP +D+LA+ GVKL + P+CTP
Sbjct: 67 EPSTTSTSQPHLIFILADDQGFRDVGYHGSE-IKTPTLDKLAAEGVKLENYYV-QPICTP 124
Query: 78 SRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHL 137
SR+ F+TG+Y + +G+ + LP D T + LK+ GYST ++GKWHL
Sbjct: 125 SRSQFITGKYQIHTGLQH-----SIIRPTQPNCLPLDNATLPQKLKEVGYSTHMVGKWHL 179
Query: 138 GMSCHSKTDFCHHPLHHGFNYFYG 161
G + K P GF+ F+G
Sbjct: 180 GF--YRKECM---PTRRGFDTFFG 198
Score = 64.3 bits (155), Expect = 3e-10
Identities = 81/351 (23%), Positives = 130/351 (37%), Gaps = 59/351 (16%)
Query: 248 YEIIQQPMSYDN---LTQRLTVEAAQFIQRNTET-PFLLVLSYLHVHTALFSSKDFAGKS 303
YE YDN TQ T Q + + T P L ++Y VH+ L + +
Sbjct: 223 YENDNAAWDYDNGIYSTQMYTQRVQQILASHNPTKPIFLYIAYQAVHSPLQAPGRYFEHY 282
Query: 304 QHGV------YGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIH 357
+ + Y + +D ++ + L N+++I ++SD G
Sbjct: 283 RSIININRRRYAAMLSCLDEAINNVTLALKTYGFYNNSIIIYSSDNGGQPTA-------- 334
Query: 358 GGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPE 417
GGSN +G K WEGGIR G + P + G E D +PT+ LA + E
Sbjct: 335 GGSNWPLRGSKGTYWEGGIRAVGFVHSPLLKNKGTVCKELVHITDWYPTLISLAEGQIDE 394
Query: 418 DRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVR----------WHPQNSTSI---- 463
D +DG D+ + + RS + H + + W+ ++I
Sbjct: 395 DIQLDGYDIWETI-SEGLRSPRVDILHNIDPIYTKAKNGSWAAGYGIWNTAIQSAIRVQH 453
Query: 464 WKAFFFTP---------NFNPVGSNGCFATHVCFCFGSYVTHHDPPLLFDISKDPRERNP 514
WK P +F+ +G N + G V LF+I+ DP ER
Sbjct: 454 WKLLTGNPGYSDWVPPQSFSNLGPNRWHNERITLSTGKSV------WLFNITADPYERVD 507
Query: 515 LTPASEPRFYEILKVMQEAADRHTQTL------PEVP-DQFSWNNFLWKPW 558
L+ R+ I+K + + +T P+ P N +W PW
Sbjct: 508 LS----NRYPGIVKKLLRRLSQFNKTAVPVRYPPKDPRSNPRLNGGVWGPW 554
>gi|59797060 arylsulfatase family, member I [Homo sapiens]
Length = 569
Score = 92.0 bits (227), Expect = 1e-18
Identities = 55/139 (39%), Positives = 79/139 (56%), Gaps = 13/139 (9%)
Query: 27 PNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGR 86
P+II ++ DD G D G +G+ I TP +DRLA+ GVKL + P+CTPSR+ +TGR
Sbjct: 47 PHIIFILTDDQGYHDVGYHGSD-IETPTLDRLAAKGVKLENYYI-QPICTPSRSQLLTGR 104
Query: 87 YPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTD 146
Y + +G+ + LP D++T + L++ GYST ++GKWHLG + K
Sbjct: 105 YQIHTGLQH-----SIIRPQQPNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGF--YRKEC 157
Query: 147 FCHHPLHHGFNYFYGISLT 165
P GF+ F G SLT
Sbjct: 158 L---PTRRGFDTFLG-SLT 172
Score = 60.1 bits (144), Expect = 6e-09
Identities = 51/195 (26%), Positives = 80/195 (41%), Gaps = 16/195 (8%)
Query: 277 ETPFLLVLSYLHVHTALFSSKDFA------GKSQHGVYGDAVEEMDWSVGQILNLLDELR 330
+ P L +++ VHT L S +++ G Y V MD +V I L
Sbjct: 226 QRPLFLYVAFQAVHTPLQSPREYLYRYRTMGNVARRKYAAMVTCMDEAVRNITWALKRYG 285
Query: 331 LANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQA 390
N+++I F+SD G GGSN +G K WEGG+R G + P +++
Sbjct: 286 FYNNSVIIFSSDNGGQT--------FSGGSNWPLRGRKGTYWEGGVRGLGFVHSP-LLKR 336
Query: 391 GQKIDEPTSNM-DIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAY 449
Q+ ++ D +PT+ LAG +DG D+ P + E L + Y
Sbjct: 337 KQRTSRALMHITDWYPTLVGLAGGTTSAADGLDGYDVWPAISEGRASPRTEILHNIDPLY 396
Query: 450 LNAVRWHPQNSTSIW 464
+A + IW
Sbjct: 397 NHAQHGSLEGGFGIW 411
>gi|4557659 iduronate-2-sulfatase isoform a precursor [Homo sapiens]
Length = 550
Score = 91.3 bits (225), Expect = 2e-18
Identities = 109/420 (25%), Positives = 175/420 (41%), Gaps = 69/420 (16%)
Query: 28 NIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRY 87
N++L++ DDL GCYG+K +R+PNID+LAS + A +C PSR +F+TGR
Sbjct: 38 NVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRR 96
Query: 88 PVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGK-WHLGMSCHSKTD 146
P T ++ F + + T + K+ GY T +GK +H G+S + D
Sbjct: 97 P--------DTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDD 148
Query: 147 FCHHPLHHGFNYFYGIS--LTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTL---- 200
P F ++ S N + C+ +G + + P+ ++ V TL
Sbjct: 149 ---SPYSWSFPPYHPSSEKYENTKTCRGPDGELHAN-----LLCPVDVLDVPEGTLPDKQ 200
Query: 201 AALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNL 260
+ + LL + S FLA + F + + + N + P D L
Sbjct: 201 STEQAIQLLE-KMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGL 259
Query: 261 TQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVG 320
QR + + Y + DF K + Y +V +D VG
Sbjct: 260 PPVAYNPWMDIRQREDVQALNISVPYGPIPV------DFQRKIRQS-YFASVSYLDTQVG 312
Query: 321 QILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPG 380
++L+ LD+L+LAN T+I FTSD G + E HG + K +N++ VP
Sbjct: 313 RLLSALDDLQLANSTIIAFTSDHGWALGE-------HG------EWAKYSNFDVATHVPL 359
Query: 381 IL----RWPRVIQAGQKI-------DEPTSNMD-------------IFPTVAKLAGAPLP 416
I R + +AG+K+ D + M+ +FPT+A LAG +P
Sbjct: 360 IFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVP 419
>gi|5360208 iduronate-2-sulfatase isoform b precursor [Homo sapiens]
Length = 343
Score = 86.3 bits (212), Expect = 7e-17
Identities = 87/324 (26%), Positives = 139/324 (42%), Gaps = 32/324 (9%)
Query: 28 NIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRY 87
N++L++ DDL GCYG+K +R+PNID+LAS + A +C PSR +F+TGR
Sbjct: 38 NVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRR 96
Query: 88 PVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGK-WHLGMSCHSKTD 146
P T ++ F + + T + K+ GY T +GK +H G+S + D
Sbjct: 97 P--------DTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDD 148
Query: 147 FCHHPLHHGFNYFYGIS--LTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTL---- 200
P F ++ S N + C+ +G + + P+ ++ V TL
Sbjct: 149 ---SPYSWSFPPYHPSSEKYENTKTCRGPDGELHAN-----LLCPVDVLDVPEGTLPDKQ 200
Query: 201 AALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNL 260
+ + LL + S FLA + F + + + N + P D L
Sbjct: 201 STEQAIQLLE-KMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGL 259
Query: 261 TQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVG 320
QR + + Y + DF K + Y +V +D VG
Sbjct: 260 PPVAYNPWMDIRQREDVQALNISVPYGPIPV------DFQRKIRQS-YFASVSYLDTQVG 312
Query: 321 QILNLLDELRLANDTLIYFTSDQG 344
++L+ LD+L+LAN T+I FTSD G
Sbjct: 313 RLLSALDDLQLANSTIIAFTSDHG 336
>gi|4504061 glucosamine (N-acetyl)-6-sulfatase precursor [Homo
sapiens]
Length = 552
Score = 60.8 bits (146), Expect = 3e-09
Identities = 98/427 (22%), Positives = 167/427 (39%), Gaps = 75/427 (17%)
Query: 26 RPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTG 85
RPN++L++ DD G T + G+ + S LC PSRA+ +TG
Sbjct: 46 RPNVVLLLTDD----QDEVLGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTG 101
Query: 86 RYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQ-GYSTALIGKWHLGMSCHSK 144
+YP + + + G ++ S + TF +L+ GY T GK+
Sbjct: 102 KYPHNHHVVNNTLEGNC--SSKSWQKIQEPNTFPAILRSMCGYQTFFAGKYLNEYGAPDA 159
Query: 145 TDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALN 204
H PL G++Y+Y + + + TL ++N
Sbjct: 160 GGLEHVPL--GWSYWYALEKNS------------------------KYYNYTL----SIN 189
Query: 205 CLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQRL 264
H G +S+ +L ++ + L FL Y F M +I P + T
Sbjct: 190 GKARKH---GENYSVDYLTDVLANVSLDFLDYKSNFEPFFM----MIATPAPHSPWTAAP 242
Query: 265 TVEAA---QFIQRN-------TETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEE 314
+ A F RN T +L+ + + + D A + + +
Sbjct: 243 QYQKAFQNVFAPRNKNFNIHGTNKHWLIRQAKTPMTNSSIQFLDNAFRKRW----QTLLS 298
Query: 315 MDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEG 374
+D V +++ L+ N+T I++TSD G H + S + K +E
Sbjct: 299 VDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPID------------KRQLYEF 346
Query: 375 GIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKS 434
I+VP ++R P I+ Q +N+D+ PT+ +AG L + + +DG L+P+L G S
Sbjct: 347 DIKVPLLVRGPG-IKPNQTSKMLVANIDLGPTILDIAGYDLNKTQ-MDGMSLLPILRGAS 404
Query: 435 Q---RSD 438
RSD
Sbjct: 405 NLTWRSD 411
>gi|39930577 arylsulfatase K [Homo sapiens]
Length = 536
Score = 57.0 bits (136), Expect = 5e-08
Identities = 61/237 (25%), Positives = 103/237 (43%), Gaps = 56/237 (23%)
Query: 285 SYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQG 344
SY T F+ K+ K+ Y E D +G+I+ L +L L T++ ++SD G
Sbjct: 258 SYTKNCTGRFTKKEI--KNIRAFYYAMCAETDAMLGEIILALHQLDLLQKTIVIYSSDHG 315
Query: 345 AHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIF 404
E+ YK + +E VP ++ P I+AG ++ S +DI+
Sbjct: 316 ----------ELAMEHRQFYK---MSMYEASAHVPLLMMGPG-IKAGLQVSNVVSLVDIY 361
Query: 405 PTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFL----------FHYCNAYLNAVR 454
PT+ +AG PLP++ + G L+P L ++ +++H+ FH CN +NA
Sbjct: 362 PTMLDIAGIPLPQN--LSGYSLLP-LSSETFKNEHKVKNLHPPWILSEFHGCN--VNAST 416
Query: 455 WHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPLLFDISKDPRE 511
+ T+ WK ++ + G+ + P LFD+S DP E
Sbjct: 417 Y--MLRTNHWK-------------------YIAYSDGASIL----PQLFDLSSDPDE 448
Score = 45.8 bits (107), Expect = 1e-04
Identities = 33/126 (26%), Positives = 55/126 (43%), Gaps = 11/126 (8%)
Query: 18 EAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTP 77
E AA PN++LV++D G++ ++ P I+ + + G SP+C P
Sbjct: 23 EQRRRAAKAPNVVLVVSDSFDGRLTFHPGSQVVKLPFINFMKTRGTSFLNAYTNSPICCP 82
Query: 78 SRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHL 137
SRAA +G + + SW+ + GL + T+ +++ GY T GK
Sbjct: 83 SRAAMWSGLFTHLT--ESWN---------NFKGLDPNYTTWMDVMERHGYRTQKFGKLDY 131
Query: 138 GMSCHS 143
HS
Sbjct: 132 TSGHHS 137
>gi|189571643 sulfatase 1 [Homo sapiens]
Length = 871
Score = 55.1 bits (131), Expect = 2e-07
Identities = 37/117 (31%), Positives = 62/117 (52%), Gaps = 15/117 (12%)
Query: 315 MDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEG 374
+D SV ++ N+L E +T I +T+D G H+ G G+ K GK+ ++
Sbjct: 289 VDDSVERLYNMLVETGELENTYIIYTADHGYHI-----------GQFGLVK-GKSMPYDF 336
Query: 375 GIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLE 431
IRVP +R P V + G + + N+D+ PT+ +AG P D +DG+ ++ LL+
Sbjct: 337 DIRVPFFIRGPSV-EPGSIVPQIVLNIDLAPTILDIAGLDTPPD--VDGKSVLKLLD 390
Score = 47.8 bits (112), Expect = 3e-05
Identities = 31/110 (28%), Positives = 50/110 (45%), Gaps = 8/110 (7%)
Query: 26 RPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTG 85
RPNIILV+ DD + G+ + + GG +P+C PSR++ +TG
Sbjct: 42 RPNIILVLTDDQDVE----LGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTG 97
Query: 86 RYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKW 135
+Y + + + ++ S + TFA L + GY TA GK+
Sbjct: 98 KYVHNHNVYTNNEN----CSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKY 143
>gi|189571641 sulfatase 1 [Homo sapiens]
Length = 871
Score = 55.1 bits (131), Expect = 2e-07
Identities = 37/117 (31%), Positives = 62/117 (52%), Gaps = 15/117 (12%)
Query: 315 MDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEG 374
+D SV ++ N+L E +T I +T+D G H+ G G+ K GK+ ++
Sbjct: 289 VDDSVERLYNMLVETGELENTYIIYTADHGYHI-----------GQFGLVK-GKSMPYDF 336
Query: 375 GIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLE 431
IRVP +R P V + G + + N+D+ PT+ +AG P D +DG+ ++ LL+
Sbjct: 337 DIRVPFFIRGPSV-EPGSIVPQIVLNIDLAPTILDIAGLDTPPD--VDGKSVLKLLD 390
Score = 47.8 bits (112), Expect = 3e-05
Identities = 31/110 (28%), Positives = 50/110 (45%), Gaps = 8/110 (7%)
Query: 26 RPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTG 85
RPNIILV+ DD + G+ + + GG +P+C PSR++ +TG
Sbjct: 42 RPNIILVLTDDQDVE----LGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTG 97
Query: 86 RYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKW 135
+Y + + + ++ S + TFA L + GY TA GK+
Sbjct: 98 KYVHNHNVYTNNEN----CSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKY 143
>gi|189571638 sulfatase 1 [Homo sapiens]
Length = 871
Score = 55.1 bits (131), Expect = 2e-07
Identities = 37/117 (31%), Positives = 62/117 (52%), Gaps = 15/117 (12%)
Query: 315 MDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEG 374
+D SV ++ N+L E +T I +T+D G H+ G G+ K GK+ ++
Sbjct: 289 VDDSVERLYNMLVETGELENTYIIYTADHGYHI-----------GQFGLVK-GKSMPYDF 336
Query: 375 GIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLE 431
IRVP +R P V + G + + N+D+ PT+ +AG P D +DG+ ++ LL+
Sbjct: 337 DIRVPFFIRGPSV-EPGSIVPQIVLNIDLAPTILDIAGLDTPPD--VDGKSVLKLLD 390
Score = 47.8 bits (112), Expect = 3e-05
Identities = 31/110 (28%), Positives = 50/110 (45%), Gaps = 8/110 (7%)
Query: 26 RPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTG 85
RPNIILV+ DD + G+ + + GG +P+C PSR++ +TG
Sbjct: 42 RPNIILVLTDDQDVE----LGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTG 97
Query: 86 RYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKW 135
+Y + + + ++ S + TFA L + GY TA GK+
Sbjct: 98 KYVHNHNVYTNNEN----CSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKY 143
>gi|189571636 sulfatase 1 [Homo sapiens]
Length = 871
Score = 55.1 bits (131), Expect = 2e-07
Identities = 37/117 (31%), Positives = 62/117 (52%), Gaps = 15/117 (12%)
Query: 315 MDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEG 374
+D SV ++ N+L E +T I +T+D G H+ G G+ K GK+ ++
Sbjct: 289 VDDSVERLYNMLVETGELENTYIIYTADHGYHI-----------GQFGLVK-GKSMPYDF 336
Query: 375 GIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLE 431
IRVP +R P V + G + + N+D+ PT+ +AG P D +DG+ ++ LL+
Sbjct: 337 DIRVPFFIRGPSV-EPGSIVPQIVLNIDLAPTILDIAGLDTPPD--VDGKSVLKLLD 390
Score = 47.8 bits (112), Expect = 3e-05
Identities = 31/110 (28%), Positives = 50/110 (45%), Gaps = 8/110 (7%)
Query: 26 RPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTG 85
RPNIILV+ DD + G+ + + GG +P+C PSR++ +TG
Sbjct: 42 RPNIILVLTDDQDVE----LGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTG 97
Query: 86 RYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKW 135
+Y + + + ++ S + TFA L + GY TA GK+
Sbjct: 98 KYVHNHNVYTNNEN----CSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKY 143
>gi|240255483 sulfatase 2 isoform a precursor [Homo sapiens]
Length = 870
Score = 53.9 bits (128), Expect = 4e-07
Identities = 39/117 (33%), Positives = 62/117 (52%), Gaps = 15/117 (12%)
Query: 315 MDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEG 374
+D S+ I N+L E ++T I +T+D G H+ G G+ K GK+ +E
Sbjct: 290 VDDSMETIYNMLVETGELDNTYIVYTADHGYHI-----------GQFGLVK-GKSMPYEF 337
Query: 375 GIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLE 431
IRVP +R P V +AG N+D+ PT+ +AG +P D +DG+ ++ LL+
Sbjct: 338 DIRVPFYVRGPNV-EAGCLNPHIVLNIDLAPTILDIAGLDIPAD--MDGKSILKLLD 391
Score = 47.8 bits (112), Expect = 3e-05
Identities = 32/110 (29%), Positives = 48/110 (43%), Gaps = 8/110 (7%)
Query: 26 RPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTG 85
RPNIILV+ DD + G+ + + GG +P+C PSR++ +TG
Sbjct: 43 RPNIILVLTDDQDVE----LGSMQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTG 98
Query: 86 RYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKW 135
+Y + T ++ S + TFA L GY TA GK+
Sbjct: 99 KYVHNHN----TYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKY 144
>gi|240255478 sulfatase 2 isoform b precursor [Homo sapiens]
Length = 867
Score = 53.9 bits (128), Expect = 4e-07
Identities = 39/117 (33%), Positives = 62/117 (52%), Gaps = 15/117 (12%)
Query: 315 MDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEG 374
+D S+ I N+L E ++T I +T+D G H+ G G+ K GK+ +E
Sbjct: 290 VDDSMETIYNMLVETGELDNTYIVYTADHGYHI-----------GQFGLVK-GKSMPYEF 337
Query: 375 GIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLE 431
IRVP +R P V +AG N+D+ PT+ +AG +P D +DG+ ++ LL+
Sbjct: 338 DIRVPFYVRGPNV-EAGCLNPHIVLNIDLAPTILDIAGLDIPAD--MDGKSILKLLD 391
Score = 47.8 bits (112), Expect = 3e-05
Identities = 32/110 (29%), Positives = 48/110 (43%), Gaps = 8/110 (7%)
Query: 26 RPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTG 85
RPNIILV+ DD + G+ + + GG +P+C PSR++ +TG
Sbjct: 43 RPNIILVLTDDQDVE----LGSMQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTG 98
Query: 86 RYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKW 135
+Y + T ++ S + TFA L GY TA GK+
Sbjct: 99 KYVHNHN----TYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKY 144
>gi|29789100 sulfatase 2 isoform a precursor [Homo sapiens]
Length = 870
Score = 53.9 bits (128), Expect = 4e-07
Identities = 39/117 (33%), Positives = 62/117 (52%), Gaps = 15/117 (12%)
Query: 315 MDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEG 374
+D S+ I N+L E ++T I +T+D G H+ G G+ K GK+ +E
Sbjct: 290 VDDSMETIYNMLVETGELDNTYIVYTADHGYHI-----------GQFGLVK-GKSMPYEF 337
Query: 375 GIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLE 431
IRVP +R P V +AG N+D+ PT+ +AG +P D +DG+ ++ LL+
Sbjct: 338 DIRVPFYVRGPNV-EAGCLNPHIVLNIDLAPTILDIAGLDIPAD--MDGKSILKLLD 391
Score = 47.8 bits (112), Expect = 3e-05
Identities = 32/110 (29%), Positives = 48/110 (43%), Gaps = 8/110 (7%)
Query: 26 RPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTG 85
RPNIILV+ DD + G+ + + GG +P+C PSR++ +TG
Sbjct: 43 RPNIILVLTDDQDVE----LGSMQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTG 98
Query: 86 RYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKW 135
+Y + T ++ S + TFA L GY TA GK+
Sbjct: 99 KYVHNHN----TYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKY 144
>gi|4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo
sapiens]
Length = 502
Score = 52.8 bits (125), Expect = 9e-07
Identities = 41/127 (32%), Positives = 62/127 (48%), Gaps = 10/127 (7%)
Query: 25 SRP-NIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFM 83
+RP N +L++ADD G + G Y N I TP++D LA + + C+PSRA+ +
Sbjct: 20 ARPRNALLLLADDGGF-ESGAYNNSAIATPHLDALARRSLLFRNAFTSVSSCSPSRASLL 78
Query: 84 TGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQ-GYSTALIGKWHLGMSCH 142
TG ++GM + V F + D++ LL Q G T +IGK H+G
Sbjct: 79 TGLPQHQNGMYGLHQ-DVHHFNS------FDKVRSLPLLLSQAGVRTGIIGKKHVGPETV 131
Query: 143 SKTDFCH 149
DF +
Sbjct: 132 YPFDFAY 138
Score = 46.6 bits (109), Expect = 6e-05
Identities = 58/244 (23%), Positives = 99/244 (40%), Gaps = 43/244 (17%)
Query: 312 VEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANN 371
V MD VG +L L + + NDTL+ FTSD G + G+ N
Sbjct: 243 VGRMDQGVGLVLQELRDAGVLNDTLVIFTSDNGIP-----------------FPSGRTNL 285
Query: 372 WEGGIRVPGILRWPRVIQA-GQKIDEPTSNMDIFPTVAKLAGAPLPEDRI-------IDG 423
+ G P ++ P + GQ + S +D+ PT+ P P I + G
Sbjct: 286 YWPGTAEPLLVSSPEHPKRWGQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTG 345
Query: 424 RDLMPLLEGK-------SQRSDHEFLFHYCNAYLNAVRWHPQNSTS------IWKAFFFT 470
R L+P LE + +S HE Y + + ++ + I + F+ +
Sbjct: 346 RSLLPALEAEPLWATVFGSQSHHEVTMSYPMRSVQHRHFRLVHNLNFKMPFPIDQDFYVS 405
Query: 471 PNFNPVGSNGCFATHVCFCFGS--YVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILK 528
P F + N A + + + L+D S+DP E L A++PRF ++L+
Sbjct: 406 PTFQDL-LNRTTAGQPTGWYKDLRHYYYRARWELYDRSRDPHETQNL--ATDPRFAQLLE 462
Query: 529 VMQE 532
++++
Sbjct: 463 MLRD 466
>gi|169217295 PREDICTED: similar to iduronate 2-sulfatase (Hunter
syndrome) [Homo sapiens]
Length = 142
Score = 45.1 bits (105), Expect = 2e-04
Identities = 29/102 (28%), Positives = 49/102 (48%), Gaps = 9/102 (8%)
Query: 47 NKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTA 106
++ ++ PNID+LAS + A +C PSR +F+TGR P T ++ F +
Sbjct: 19 DELVKAPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRP--------DTTRLYDFNS 70
Query: 107 SSGGLPTDEITFAKLLKDQGYSTALIGK-WHLGMSCHSKTDF 147
+ T + K+ GY T +GK +H G + ++ F
Sbjct: 71 YWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGTAPRPESGF 112
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.140 0.449
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,539,748
Number of Sequences: 37866
Number of extensions: 1100376
Number of successful extensions: 2353
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 2202
Number of HSP's gapped (non-prelim): 65
length of query: 583
length of database: 18,247,518
effective HSP length: 108
effective length of query: 475
effective length of database: 14,157,990
effective search space: 6725045250
effective search space used: 6725045250
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.