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Search of human proteins with 51988914
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|51988914 fibroblast growth factor receptor-like 1 precursor
[Homo sapiens]
(504 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|51988914 fibroblast growth factor receptor-like 1 precursor [... 1048 0.0
gi|51988910 fibroblast growth factor receptor-like 1 precursor [... 1048 0.0
gi|51988912 fibroblast growth factor receptor-like 1 precursor [... 1048 0.0
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 176 6e-44
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 172 8e-43
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 172 8e-43
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu... 171 1e-42
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 168 1e-41
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 167 2e-41
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 167 2e-41
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 164 2e-40
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 161 1e-39
gi|13186249 fibroblast growth factor receptor 1 isoform 9 precur... 160 3e-39
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu... 160 3e-39
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur... 149 6e-36
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu... 149 8e-36
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu... 147 3e-35
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu... 147 3e-35
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu... 145 1e-34
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu... 142 5e-34
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 140 4e-33
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 138 1e-32
gi|13186241 fibroblast growth factor receptor 1 isoform 6 precur... 120 2e-27
gi|13186238 fibroblast growth factor receptor 1 isoform 5 precur... 119 8e-27
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 107 2e-23
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 107 3e-23
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 107 3e-23
gi|118572606 hemicentin 1 [Homo sapiens] 105 1e-22
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu... 103 5e-22
gi|224994173 roundabout 1 isoform d [Homo sapiens] 101 1e-21
>gi|51988914 fibroblast growth factor receptor-like 1 precursor
[Homo sapiens]
Length = 504
Score = 1048 bits (2709), Expect = 0.0
Identities = 504/504 (100%), Positives = 504/504 (100%)
Query: 1 MTPSPLLLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPL 60
MTPSPLLLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPL
Sbjct: 1 MTPSPLLLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPL 60
Query: 61 TMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDI 120
TMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDI
Sbjct: 61 TMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDI 120
Query: 121 SPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRP 180
SPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRP
Sbjct: 121 SPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRP 180
Query: 181 DITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQ 240
DITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQ
Sbjct: 181 DITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQ 240
Query: 241 RTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGG 300
RTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGG
Sbjct: 241 RTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGG 300
Query: 301 QKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPK 360
QKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPK
Sbjct: 301 QKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPK 360
Query: 361 PPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWLCQAQKKPCTPAPAPPLPGHRPP 420
PPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWLCQAQKKPCTPAPAPPLPGHRPP
Sbjct: 361 PPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWLCQAQKKPCTPAPAPPLPGHRPP 420
Query: 421 GTARDRSGDKDLPSLAALSAGPGVGLCEEHGSPAAPQHLLGPGPVAGPKLYPKLYTDIHT 480
GTARDRSGDKDLPSLAALSAGPGVGLCEEHGSPAAPQHLLGPGPVAGPKLYPKLYTDIHT
Sbjct: 421 GTARDRSGDKDLPSLAALSAGPGVGLCEEHGSPAAPQHLLGPGPVAGPKLYPKLYTDIHT 480
Query: 481 HTHTHSHTHSHVEGKVHQHIHYQC 504
HTHTHSHTHSHVEGKVHQHIHYQC
Sbjct: 481 HTHTHSHTHSHVEGKVHQHIHYQC 504
>gi|51988910 fibroblast growth factor receptor-like 1 precursor
[Homo sapiens]
Length = 504
Score = 1048 bits (2709), Expect = 0.0
Identities = 504/504 (100%), Positives = 504/504 (100%)
Query: 1 MTPSPLLLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPL 60
MTPSPLLLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPL
Sbjct: 1 MTPSPLLLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPL 60
Query: 61 TMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDI 120
TMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDI
Sbjct: 61 TMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDI 120
Query: 121 SPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRP 180
SPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRP
Sbjct: 121 SPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRP 180
Query: 181 DITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQ 240
DITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQ
Sbjct: 181 DITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQ 240
Query: 241 RTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGG 300
RTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGG
Sbjct: 241 RTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGG 300
Query: 301 QKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPK 360
QKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPK
Sbjct: 301 QKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPK 360
Query: 361 PPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWLCQAQKKPCTPAPAPPLPGHRPP 420
PPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWLCQAQKKPCTPAPAPPLPGHRPP
Sbjct: 361 PPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWLCQAQKKPCTPAPAPPLPGHRPP 420
Query: 421 GTARDRSGDKDLPSLAALSAGPGVGLCEEHGSPAAPQHLLGPGPVAGPKLYPKLYTDIHT 480
GTARDRSGDKDLPSLAALSAGPGVGLCEEHGSPAAPQHLLGPGPVAGPKLYPKLYTDIHT
Sbjct: 421 GTARDRSGDKDLPSLAALSAGPGVGLCEEHGSPAAPQHLLGPGPVAGPKLYPKLYTDIHT 480
Query: 481 HTHTHSHTHSHVEGKVHQHIHYQC 504
HTHTHSHTHSHVEGKVHQHIHYQC
Sbjct: 481 HTHTHSHTHSHVEGKVHQHIHYQC 504
>gi|51988912 fibroblast growth factor receptor-like 1 precursor
[Homo sapiens]
Length = 504
Score = 1048 bits (2709), Expect = 0.0
Identities = 504/504 (100%), Positives = 504/504 (100%)
Query: 1 MTPSPLLLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPL 60
MTPSPLLLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPL
Sbjct: 1 MTPSPLLLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPL 60
Query: 61 TMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDI 120
TMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDI
Sbjct: 61 TMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDI 120
Query: 121 SPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRP 180
SPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRP
Sbjct: 121 SPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRP 180
Query: 181 DITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQ 240
DITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQ
Sbjct: 181 DITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQ 240
Query: 241 RTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGG 300
RTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGG
Sbjct: 241 RTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGG 300
Query: 301 QKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPK 360
QKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPK
Sbjct: 301 QKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPK 360
Query: 361 PPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWLCQAQKKPCTPAPAPPLPGHRPP 420
PPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWLCQAQKKPCTPAPAPPLPGHRPP
Sbjct: 361 PPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWLCQAQKKPCTPAPAPPLPGHRPP 420
Query: 421 GTARDRSGDKDLPSLAALSAGPGVGLCEEHGSPAAPQHLLGPGPVAGPKLYPKLYTDIHT 480
GTARDRSGDKDLPSLAALSAGPGVGLCEEHGSPAAPQHLLGPGPVAGPKLYPKLYTDIHT
Sbjct: 421 GTARDRSGDKDLPSLAALSAGPGVGLCEEHGSPAAPQHLLGPGPVAGPKLYPKLYTDIHT 480
Query: 481 HTHTHSHTHSHVEGKVHQHIHYQC 504
HTHTHSHTHSHVEGKVHQHIHYQC
Sbjct: 481 HTHTHSHTHSHVEGKVHQHIHYQC 504
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 176 bits (445), Expect = 6e-44
Identities = 132/429 (30%), Positives = 202/429 (47%), Gaps = 33/429 (7%)
Query: 44 GRTVRLQCPVEGDPPP-LTMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKAT 102
G V L CP G P T+W KDG + R V PQ L+V ED+G Y C+
Sbjct: 54 GDAVELSCPPPGGGPMGPTVWVKDGTGLVPS-ERVLVGPQRLQVLNASHEDSGAYSCRQR 112
Query: 103 NGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIAR 162
L ++++ V D S G + G D + D + W T+P +M ++++A
Sbjct: 113 LTQRVLC-HFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYW-----TRPERMDKKLLAV 166
Query: 163 PVGSSVRLKCVASGHPRPDITWMKDDQALT---RPEAAEPRKKKWTLSLKNLRPEDSGKY 219
P ++VR +C A+G+P P I+W+K+ + R + R ++W+L ++++ P D G Y
Sbjct: 167 PAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNY 226
Query: 220 TCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQ 279
TC V N+ G+I TY +DV++R+ +P+L P N T G F CKV SD +P IQ
Sbjct: 227 TCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQ 286
Query: 280 WLKRVEYGAEGRHNSTIDVGGQKFV-VLPTGDVWSRPDGSYLNKLLITRARQDDAGMYIC 338
WLK VE + S + G +V VL T + L L + +DAG Y C
Sbjct: 287 WLKHVEV-----NGSKVGPDGTPYVTVLKTAG--ANTTDKELEVLSLHNVTFEDAGEYTC 339
Query: 339 LGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWL 398
L N++G+S SA+L VLP + + + A S+ ++ +FIL + L
Sbjct: 340 LAGNSIGFSHHSAWLVVLPAEE----ELVEADEAGSVYAGILSYGVGFFLFILVVAAVTL 395
Query: 399 CQAQKKPCTPAPAP--------PLPGHRPPGTARDRSGDKDLPSLAALSAGPGVGLC--E 448
C+ + P +P PL + S + L +A LS+G G L
Sbjct: 396 CRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVS 455
Query: 449 EHGSPAAPQ 457
E PA P+
Sbjct: 456 ELELPADPK 464
Score = 33.1 bits (74), Expect = 0.61
Identities = 34/117 (29%), Positives = 40/117 (34%), Gaps = 30/117 (25%)
Query: 39 QVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--------------- 83
Q A LG V C V D P W K H + +V P G
Sbjct: 263 QTAVLGSDVEFHCKVYSDAQPHIQWLK-----HVEVNGSKVGPDGTPYVTVLKTAGANTT 317
Query: 84 ------LKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSG 134
L + V EDAG Y C A N G + LVVL P +E L +G
Sbjct: 318 DKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVL----PAEEELVEADEAG 370
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 172 bits (435), Expect = 8e-43
Identities = 125/385 (32%), Positives = 185/385 (48%), Gaps = 32/385 (8%)
Query: 6 LLLLLLPPLLLGAFPPAAAARGP------PKMADKVVPRQ---VARLGRTVRLQCPVEGD 56
LLL LL LL PP + P +A + ++ LG+ VRL C G
Sbjct: 3 LLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCC---GR 59
Query: 57 PPPLTMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSV--NYTL 114
W K+G + R R L++ EDAG Y+C A GS+ V N TL
Sbjct: 60 AERGGHWYKEGSRLAPA-GRVRGWRGRLEIASFLPEDAGRYLCLAR---GSMIVLQNLTL 115
Query: 115 VVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVA 174
+ D ++ + P S + Q A P +T P +M +++ A P G++V+ +C A
Sbjct: 116 ITGDSLTSSNDDEDPKSHRDPSNRHSYPQQA-PYWTHPQRMEKKLHAVPAGNTVKFRCPA 174
Query: 175 SGHPRPDITWMKDDQAL---TRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAIN 231
+G+P P I W+KD QA R R + W+L ++++ P D G YTC V N G+I
Sbjct: 175 AGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIR 234
Query: 232 ATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGR 291
Y +DV++R+ +P+L P NTT G CKV SD +P IQWLK +
Sbjct: 235 YNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVI----- 289
Query: 292 HNSTIDVGGQKFV-VLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRS 350
+ S+ G +V VL T D+ + S + L + +DAG Y CL N++G S++S
Sbjct: 290 NGSSFGADGFPYVQVLKTADI----NSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQS 345
Query: 351 AFLTVLPDPKPPGPPVASSSSATSL 375
A+LTVLP+ P A + T +
Sbjct: 346 AWLTVLPEEDPTWTAAAPEARYTDI 370
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 172 bits (435), Expect = 8e-43
Identities = 125/385 (32%), Positives = 185/385 (48%), Gaps = 32/385 (8%)
Query: 6 LLLLLLPPLLLGAFPPAAAARGP------PKMADKVVPRQ---VARLGRTVRLQCPVEGD 56
LLL LL LL PP + P +A + ++ LG+ VRL C G
Sbjct: 3 LLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCC---GR 59
Query: 57 PPPLTMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSV--NYTL 114
W K+G + R R L++ EDAG Y+C A GS+ V N TL
Sbjct: 60 AERGGHWYKEGSRLAPA-GRVRGWRGRLEIASFLPEDAGRYLCLAR---GSMIVLQNLTL 115
Query: 115 VVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVA 174
+ D ++ + P S + Q A P +T P +M +++ A P G++V+ +C A
Sbjct: 116 ITGDSLTSSNDDEDPKSHRDPSNRHSYPQQA-PYWTHPQRMEKKLHAVPAGNTVKFRCPA 174
Query: 175 SGHPRPDITWMKDDQAL---TRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAIN 231
+G+P P I W+KD QA R R + W+L ++++ P D G YTC V N G+I
Sbjct: 175 AGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIR 234
Query: 232 ATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGR 291
Y +DV++R+ +P+L P NTT G CKV SD +P IQWLK +
Sbjct: 235 YNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVI----- 289
Query: 292 HNSTIDVGGQKFV-VLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRS 350
+ S+ G +V VL T D+ + S + L + +DAG Y CL N++G S++S
Sbjct: 290 NGSSFGADGFPYVQVLKTADI----NSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQS 345
Query: 351 AFLTVLPDPKPPGPPVASSSSATSL 375
A+LTVLP+ P A + T +
Sbjct: 346 AWLTVLPEEDPTWTAAAPEARYTDI 370
>gi|221316639 fibroblast growth factor receptor 2 isoform 1
precursor [Homo sapiens]
Length = 821
Score = 171 bits (434), Expect = 1e-42
Identities = 115/376 (30%), Positives = 187/376 (49%), Gaps = 24/376 (6%)
Query: 40 VARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVL-PQGLKVKQVEREDAGVYV 98
VA G ++ ++C ++ + WTKDG +H G + VL + L++K D+G+Y
Sbjct: 51 VAAPGESLEVRCLLKD--AAVISWTKDG--VHLGPNNRTVLIGEYLQIKGATPRDSGLYA 106
Query: 99 CKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRR 158
C A+ S + + + V D IS G + D + + ++ + A P +T KM +R
Sbjct: 107 CTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA-PYWTNTEKMEKR 165
Query: 159 VIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAA---EPRKKKWTLSLKNLRPED 215
+ A P ++V+ +C A G+P P + W+K+ + + + R + W+L ++++ P D
Sbjct: 166 LHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSD 225
Query: 216 SGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVK 275
G YTC V N G+IN TY +DV++R+ +P+L P N + GG F CKV SD +
Sbjct: 226 KGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQ 285
Query: 276 PVIQWLKRVEYGAEGRHNSTIDVGGQKFV-VLPTGDVWSRPDGSYLNKLLITRARQDDAG 334
P IQW+K VE ++ S G ++ VL V + L I +DAG
Sbjct: 286 PHIQWIKHVE-----KNGSKYGPDGLPYLKVLKAAGV--NTTDKEIEVLYIRNVTFEDAG 338
Query: 335 MYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIPAGAVFILGTL 394
Y CL N++G SF SA+LTVLP P T+ P + I I VF++ +
Sbjct: 339 EYTCLAGNSIGISFHSAWLTVLPAP-------GREKEITASPDYLEIAIYCIGVFLIACM 391
Query: 395 LLWLCQAQKKPCTPAP 410
++ + + K T P
Sbjct: 392 VVTVILCRMKNTTKKP 407
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 168 bits (425), Expect = 1e-41
Identities = 122/367 (33%), Positives = 179/367 (48%), Gaps = 32/367 (8%)
Query: 6 LLLLLLPPLLLGAFPPAAAARGP------PKMADKVVPRQ---VARLGRTVRLQCPVEGD 56
LLL LL LL PP + P +A + ++ LG+ VRL C G
Sbjct: 3 LLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCC---GR 59
Query: 57 PPPLTMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSV--NYTL 114
W K+G + R R L++ EDAG Y+C A GS+ V N TL
Sbjct: 60 AERGGHWYKEGSRLAPA-GRVRGWRGRLEIASFLPEDAGRYLCLAR---GSMIVLQNLTL 115
Query: 115 VVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVA 174
+ D ++ + P S + Q A P +T P +M +++ A P G++V+ +C A
Sbjct: 116 ITGDSLTSSNDDEDPKSHRDPSNRHSYPQQA-PYWTHPQRMEKKLHAVPAGNTVKFRCPA 174
Query: 175 SGHPRPDITWMKDDQAL---TRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAIN 231
+G+P P I W+KD QA R R + W+L ++++ P D G YTC V N G+I
Sbjct: 175 AGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIR 234
Query: 232 ATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGR 291
Y +DV++R+ +P+L P NTT G CKV SD +P IQWLK +
Sbjct: 235 YNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVI----- 289
Query: 292 HNSTIDVGGQKFV-VLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRS 350
+ S+ G +V VL T D+ + S + L + +DAG Y CL N++G S++S
Sbjct: 290 NGSSFGADGFPYVQVLKTADI----NSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQS 345
Query: 351 AFLTVLP 357
A+LTVLP
Sbjct: 346 AWLTVLP 352
Score = 71.2 bits (173), Expect = 2e-12
Identities = 64/225 (28%), Positives = 84/225 (37%), Gaps = 47/225 (20%)
Query: 44 GRTVRLQCPVEGDPPPLTMWTKDGRTIHS----GWSRFRVLPQGLKVKQVEREDAGVYVC 99
G TV+ +CP G+P P W KDG+ H G R R L ++ V D G Y C
Sbjct: 165 GNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTC 224
Query: 100 KATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRV 159
N GS+ NY L VL+ SP + L Q P T
Sbjct: 225 LVENAVGSIRYNYLLDVLER-SPHRPIL---------------QAGLPANT--------- 259
Query: 160 IARPVGSSVRLKCVASGHPRPDITWMKDD---------------QALTRPEAAEPRKKKW 204
VGS V L C +P I W+K Q L + +
Sbjct: 260 -TAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVE-- 316
Query: 205 TLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLT 249
L L+N+ ED+G+YTC N G + + V+ T P LT
Sbjct: 317 VLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPGTGRIPHLT 361
>gi|222144231 fibroblast growth factor receptor 2 isoform 3
precursor [Homo sapiens]
Length = 769
Score = 167 bits (424), Expect = 2e-41
Identities = 113/376 (30%), Positives = 190/376 (50%), Gaps = 23/376 (6%)
Query: 40 VARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVL-PQGLKVKQVEREDAGVYV 98
VA G ++ ++C ++ + WTKDG +H G + VL + L++K D+G+Y
Sbjct: 51 VAAPGESLEVRCLLKD--AAVISWTKDG--VHLGPNNRTVLIGEYLQIKGATPRDSGLYA 106
Query: 99 CKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRR 158
C A+ S + + + V D IS G + D + + ++ + A P +T KM +R
Sbjct: 107 CTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA-PYWTNTEKMEKR 165
Query: 159 VIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAA---EPRKKKWTLSLKNLRPED 215
+ A P ++V+ +C A G+P P + W+K+ + + + R + W+L ++++ P D
Sbjct: 166 LHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSD 225
Query: 216 SGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVK 275
G YTC V N G+IN TY +DV++R+ +P+L P N + GG F CKV SD +
Sbjct: 226 KGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQ 285
Query: 276 PVIQWLKRVEYGAEGRHNSTIDVGGQKFV-VLPTGDVWSRPDGSYLNKLLITRARQDDAG 334
P IQW+K VE ++ S G ++ VL + + S L + + DAG
Sbjct: 286 PHIQWIKHVE-----KNGSKYGPDGLPYLKVLKHSGI----NSSNAEVLALFNVTEADAG 336
Query: 335 MYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIPAGAVFILGTL 394
YIC +N +G + +SA+LTVLP + PG T+ P + I I VF++ +
Sbjct: 337 EYICKVSNYIGQANQSAWLTVLPKQQAPG----REKEITASPDYLEIAIYCIGVFLIACM 392
Query: 395 LLWLCQAQKKPCTPAP 410
++ + + K T P
Sbjct: 393 VVTVILCRMKNTTKKP 408
>gi|221316638 fibroblast growth factor receptor 2 isoform 2
precursor [Homo sapiens]
Length = 822
Score = 167 bits (424), Expect = 2e-41
Identities = 113/376 (30%), Positives = 190/376 (50%), Gaps = 23/376 (6%)
Query: 40 VARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVL-PQGLKVKQVEREDAGVYV 98
VA G ++ ++C ++ + WTKDG +H G + VL + L++K D+G+Y
Sbjct: 51 VAAPGESLEVRCLLKD--AAVISWTKDG--VHLGPNNRTVLIGEYLQIKGATPRDSGLYA 106
Query: 99 CKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRR 158
C A+ S + + + V D IS G + D + + ++ + A P +T KM +R
Sbjct: 107 CTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA-PYWTNTEKMEKR 165
Query: 159 VIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAA---EPRKKKWTLSLKNLRPED 215
+ A P ++V+ +C A G+P P + W+K+ + + + R + W+L ++++ P D
Sbjct: 166 LHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSD 225
Query: 216 SGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVK 275
G YTC V N G+IN TY +DV++R+ +P+L P N + GG F CKV SD +
Sbjct: 226 KGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQ 285
Query: 276 PVIQWLKRVEYGAEGRHNSTIDVGGQKFV-VLPTGDVWSRPDGSYLNKLLITRARQDDAG 334
P IQW+K VE ++ S G ++ VL + + S L + + DAG
Sbjct: 286 PHIQWIKHVE-----KNGSKYGPDGLPYLKVLKHSGI----NSSNAEVLALFNVTEADAG 336
Query: 335 MYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIPAGAVFILGTL 394
YIC +N +G + +SA+LTVLP + PG T+ P + I I VF++ +
Sbjct: 337 EYICKVSNYIGQANQSAWLTVLPKQQAPG----REKEITASPDYLEIAIYCIGVFLIACM 392
Query: 395 LLWLCQAQKKPCTPAP 410
++ + + K T P
Sbjct: 393 VVTVILCRMKNTTKKP 408
>gi|254028242 fibroblast growth factor receptor 3 isoform 3
precursor [Homo sapiens]
Length = 808
Score = 164 bits (415), Expect = 2e-40
Identities = 123/428 (28%), Positives = 197/428 (46%), Gaps = 29/428 (6%)
Query: 44 GRTVRLQCPVEGDPPP-LTMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKAT 102
G V L CP G P T+W KDG + R V PQ L+V ED+G Y C+
Sbjct: 54 GDAVELSCPPPGGGPMGPTVWVKDGTGLVPS-ERVLVGPQRLQVLNASHEDSGAYSCRQR 112
Query: 103 NGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIAR 162
L ++++ V D S G + G D + D + W T+P +M ++++A
Sbjct: 113 LTQRVLC-HFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYW-----TRPERMDKKLLAV 166
Query: 163 PVGSSVRLKCVASGHPRPDITWMKDDQALT---RPEAAEPRKKKWTLSLKNLRPEDSGKY 219
P ++VR +C A+G+P P I+W+K+ + R + R ++W+L ++++ P D G Y
Sbjct: 167 PAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNY 226
Query: 220 TCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQ 279
TC V N+ G+I TY +DV++R+ +P+L P N T G F CKV SD +P IQ
Sbjct: 227 TCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQ 286
Query: 280 WLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICL 339
WLK VE + S + G +V + W +L + + D G Y+C
Sbjct: 287 WLKHVEV-----NGSKVGPDGTPYVTVLKS--WISESVEADVRLRLANVSERDGGEYLCR 339
Query: 340 GANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWLC 399
N +G + ++ +L+V P+ + + A S+ ++ +FIL + LC
Sbjct: 340 ATNFIGVAEKAFWLSV-HGPRAAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLC 398
Query: 400 QAQKKPCTPAPAP--------PLPGHRPPGTARDRSGDKDLPSLAALSAGPGVGLC--EE 449
+ + P +P PL + S + L +A LS+G G L E
Sbjct: 399 RLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSE 458
Query: 450 HGSPAAPQ 457
PA P+
Sbjct: 459 LELPADPK 466
Score = 34.3 bits (77), Expect = 0.27
Identities = 26/83 (31%), Positives = 31/83 (37%), Gaps = 15/83 (18%)
Query: 39 QVARLGRTVRLQCPVEGDPPPLTMWTK-----------DGR---TIHSGW-SRFRVLPQG 83
Q A LG V C V D P W K DG T+ W S
Sbjct: 263 QTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVR 322
Query: 84 LKVKQVEREDAGVYVCKATNGFG 106
L++ V D G Y+C+ATN G
Sbjct: 323 LRLANVSERDGGEYLCRATNFIG 345
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 161 bits (408), Expect = 1e-39
Identities = 106/343 (30%), Positives = 163/343 (47%), Gaps = 17/343 (4%)
Query: 21 PAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVL 80
P + P A V + G ++L+C + D + W +DG + +R R+
Sbjct: 25 PTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSIN-WLRDGVQLAES-NRTRIT 82
Query: 81 PQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQE--- 137
+ ++V+ D+G+Y C ++ GS Y V + D P E D S +E
Sbjct: 83 GEEVEVQDSVPADSGLYACVTSSPSGS-DTTYFSVNVSDALPSSEDDDDDDDSSSEEKET 141
Query: 138 DPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALT---RP 194
D P +T P KM +++ A P +V+ KC +SG P P + W+K+ + R
Sbjct: 142 DNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRI 201
Query: 195 EAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPV 254
+ R W++ + ++ P D G YTC V N G+IN TY++DV++R+ +P+L P
Sbjct: 202 GGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPA 261
Query: 255 NTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFV-VLPTGDVWS 313
N TV G F CKV SD +P IQWLK +E + S I +V +L T V
Sbjct: 262 NKTVALGSNVEFMCKVYSDPQPHIQWLKHIEV-----NGSKIGPDNLPYVQILKTAGV-- 314
Query: 314 RPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVL 356
+ L + +DAG Y CL N++G S SA+LTVL
Sbjct: 315 NTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL 357
Score = 65.1 bits (157), Expect = 1e-10
Identities = 65/273 (23%), Positives = 100/273 (36%), Gaps = 49/273 (17%)
Query: 20 PPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHS----GWS 75
P A P KM K+ +TV+ +CP G P P W K+G+ G
Sbjct: 148 PVAPYWTSPEKMEKKL---HAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGY 204
Query: 76 RFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGG 135
+ R + + V D G Y C N +GS++ Y L V++ SP + L
Sbjct: 205 KVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVER-SPHRPIL-------- 255
Query: 136 QEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDD------- 188
Q + +A +GS+V C P+P I W+K
Sbjct: 256 ---------------QAGLPANKTVA--LGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI 298
Query: 189 --------QALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQ 240
Q L K+ L L+N+ ED+G+YTC N G + + + V++
Sbjct: 299 GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE 358
Query: 241 RTRSKP-VLTGTHPVNTTVDFGGTTSFQCKVRS 272
+P V+T + + G C V S
Sbjct: 359 ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGS 391
>gi|13186249 fibroblast growth factor receptor 1 isoform 9 precursor
[Homo sapiens]
Length = 785
Score = 160 bits (404), Expect = 3e-39
Identities = 103/344 (29%), Positives = 170/344 (49%), Gaps = 17/344 (4%)
Query: 21 PAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVL 80
P + P A V + G ++L+C + D + W +DG + +R R+
Sbjct: 25 PTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSIN-WLRDGVQLAES-NRTRIT 82
Query: 81 PQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPA 140
+ ++V+ D+G+Y C ++ GS + +++ V D + ++ D SS +++
Sbjct: 83 GEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETD 142
Query: 141 SQQWAR----PRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALT---R 193
+ + R P +T P KM +++ A P +V+ KC +SG P P + W+K+ + R
Sbjct: 143 NTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHR 202
Query: 194 PEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHP 253
+ R W++ + ++ P D G YTC V N G+IN TY++DV++R+ +P+L P
Sbjct: 203 IGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLP 262
Query: 254 VNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFV-VLPTGDVW 312
N TV G F CKV SD +P IQWLK +E + S I +V +L T V
Sbjct: 263 ANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEV-----NGSKIGPDNLPYVQILKTAGV- 316
Query: 313 SRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVL 356
+ L + +DAG Y CL N++G S SA+LTVL
Sbjct: 317 -NTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL 359
Score = 65.1 bits (157), Expect = 1e-10
Identities = 65/273 (23%), Positives = 100/273 (36%), Gaps = 49/273 (17%)
Query: 20 PPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHS----GWS 75
P A P KM K+ +TV+ +CP G P P W K+G+ G
Sbjct: 150 PVAPYWTSPEKMEKKL---HAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGY 206
Query: 76 RFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGG 135
+ R + + V D G Y C N +GS++ Y L V++ SP + L
Sbjct: 207 KVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVER-SPHRPIL-------- 257
Query: 136 QEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDD------- 188
Q + +A +GS+V C P+P I W+K
Sbjct: 258 ---------------QAGLPANKTVA--LGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI 300
Query: 189 --------QALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQ 240
Q L K+ L L+N+ ED+G+YTC N G + + + V++
Sbjct: 301 GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE 360
Query: 241 RTRSKP-VLTGTHPVNTTVDFGGTTSFQCKVRS 272
+P V+T + + G C V S
Sbjct: 361 ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGS 393
>gi|105990522 fibroblast growth factor receptor 1 isoform 1
precursor [Homo sapiens]
Length = 822
Score = 160 bits (404), Expect = 3e-39
Identities = 103/344 (29%), Positives = 170/344 (49%), Gaps = 17/344 (4%)
Query: 21 PAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVL 80
P + P A V + G ++L+C + D + W +DG + +R R+
Sbjct: 25 PTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSIN-WLRDGVQLAES-NRTRIT 82
Query: 81 PQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPA 140
+ ++V+ D+G+Y C ++ GS + +++ V D + ++ D SS +++
Sbjct: 83 GEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETD 142
Query: 141 SQQWAR----PRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALT---R 193
+ + R P +T P KM +++ A P +V+ KC +SG P P + W+K+ + R
Sbjct: 143 NTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHR 202
Query: 194 PEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHP 253
+ R W++ + ++ P D G YTC V N G+IN TY++DV++R+ +P+L P
Sbjct: 203 IGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLP 262
Query: 254 VNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFV-VLPTGDVW 312
N TV G F CKV SD +P IQWLK +E + S I +V +L T V
Sbjct: 263 ANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEV-----NGSKIGPDNLPYVQILKTAGV- 316
Query: 313 SRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVL 356
+ L + +DAG Y CL N++G S SA+LTVL
Sbjct: 317 -NTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL 359
Score = 65.1 bits (157), Expect = 1e-10
Identities = 65/273 (23%), Positives = 100/273 (36%), Gaps = 49/273 (17%)
Query: 20 PPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHS----GWS 75
P A P KM K+ +TV+ +CP G P P W K+G+ G
Sbjct: 150 PVAPYWTSPEKMEKKL---HAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGY 206
Query: 76 RFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGG 135
+ R + + V D G Y C N +GS++ Y L V++ SP + L
Sbjct: 207 KVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVER-SPHRPIL-------- 257
Query: 136 QEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDD------- 188
Q + +A +GS+V C P+P I W+K
Sbjct: 258 ---------------QAGLPANKTVA--LGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI 300
Query: 189 --------QALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQ 240
Q L K+ L L+N+ ED+G+YTC N G + + + V++
Sbjct: 301 GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE 360
Query: 241 RTRSKP-VLTGTHPVNTTVDFGGTTSFQCKVRS 272
+P V+T + + G C V S
Sbjct: 361 ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGS 393
>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
[Homo sapiens]
Length = 694
Score = 149 bits (376), Expect = 6e-36
Identities = 86/246 (34%), Positives = 130/246 (52%), Gaps = 11/246 (4%)
Query: 44 GRTVRLQCPVEGDPPP-LTMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKAT 102
G V L CP G P T+W KDG + R V PQ L+V ED+G Y C+
Sbjct: 54 GDAVELSCPPPGGGPMGPTVWVKDGTGLVPS-ERVLVGPQRLQVLNASHEDSGAYSCRQR 112
Query: 103 NGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIAR 162
L ++++ V D S G + G D + D + W T+P +M ++++A
Sbjct: 113 LTQRVLC-HFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYW-----TRPERMDKKLLAV 166
Query: 163 PVGSSVRLKCVASGHPRPDITWMKDDQALT---RPEAAEPRKKKWTLSLKNLRPEDSGKY 219
P ++VR +C A+G+P P I+W+K+ + R + R ++W+L ++++ P D G Y
Sbjct: 167 PAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNY 226
Query: 220 TCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQ 279
TC V N+ G+I TY +DV++R+ +P+L P N T G F CKV SD +P IQ
Sbjct: 227 TCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQ 286
Query: 280 WLKRVE 285
WLK VE
Sbjct: 287 WLKHVE 292
>gi|222144235 fibroblast growth factor receptor 2 isoform 5
precursor [Homo sapiens]
Length = 707
Score = 149 bits (375), Expect = 8e-36
Identities = 97/308 (31%), Positives = 152/308 (49%), Gaps = 19/308 (6%)
Query: 107 SLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGS 166
SL + TL D IS G + D + + ++ + A P +T KM +R+ A P +
Sbjct: 26 SLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSNNKRA-PYWTNTEKMEKRLHAVPAAN 84
Query: 167 SVRLKCVASGHPRPDITWMKDDQALTRPEAA---EPRKKKWTLSLKNLRPEDSGKYTCRV 223
+V+ +C A G+P P + W+K+ + + + R + W+L ++++ P D G YTC V
Sbjct: 85 TVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVV 144
Query: 224 SNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKR 283
N G+IN TY +DV++R+ +P+L P N + GG F CKV SD +P IQW+K
Sbjct: 145 ENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKH 204
Query: 284 VEYGAEGRHNSTIDVGGQKFV-VLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGAN 342
VE ++ S G ++ VL V + L I +DAG Y CL N
Sbjct: 205 VE-----KNGSKYGPDGLPYLKVLKAAGV--NTTDKEIEVLYIRNVTFEDAGEYTCLAGN 257
Query: 343 TMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWLCQAQ 402
++G SF SA+LTVLP P T+ P + I I VF++ +++ + +
Sbjct: 258 SIGISFHSAWLTVLPAP-------GREKEITASPDYLEIAIYCIGVFLIACMVVTVILCR 310
Query: 403 KKPCTPAP 410
K T P
Sbjct: 311 MKNTTKKP 318
Score = 50.8 bits (120), Expect = 3e-06
Identities = 50/202 (24%), Positives = 73/202 (36%), Gaps = 45/202 (22%)
Query: 46 TVRLQCPVEGDPPPLTMWTKDGRTIHS----GWSRFRVLPQGLKVKQVEREDAGVYVCKA 101
TV+ +CP G+P P W K+G+ G + R L ++ V D G Y C
Sbjct: 85 TVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVV 144
Query: 102 TNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIA 161
N +GS++ Y L V++ SP + L G AS
Sbjct: 145 ENEYGSINHTYHLDVVER-SPHRPIL-----QAGLPANAS-------------------- 178
Query: 162 RPVGSSVRLKCVASGHPRPDITWMKDDQ---------------ALTRPEAAEPRKKKWTL 206
VG V C +P I W+K + L K+ L
Sbjct: 179 TVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVL 238
Query: 207 SLKNLRPEDSGKYTCRVSNRAG 228
++N+ ED+G+YTC N G
Sbjct: 239 YIRNVTFEDAGEYTCLAGNSIG 260
Score = 29.3 bits (64), Expect = 8.8
Identities = 29/99 (29%), Positives = 36/99 (36%), Gaps = 18/99 (18%)
Query: 43 LGRTVRLQCPVEGDPPPLTMWTKDGRTIHS-----GWSRFRVLPQG-----------LKV 86
+G V C V D P W K S G +VL L +
Sbjct: 181 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 240
Query: 87 KQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKE 125
+ V EDAG Y C A N G + L VL +PG+E
Sbjct: 241 RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLP--APGRE 277
>gi|222144241 fibroblast growth factor receptor 2 isoform 8
precursor [Homo sapiens]
Length = 704
Score = 147 bits (370), Expect = 3e-35
Identities = 89/278 (32%), Positives = 138/278 (49%), Gaps = 18/278 (6%)
Query: 137 EDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEA 196
ED + P +T KM +R+ A P ++V+ +C A G+P P + W+K+ + +
Sbjct: 29 EDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR 88
Query: 197 A---EPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHP 253
+ R + W+L ++++ P D G YTC V N G+IN TY +DV++R+ +P+L P
Sbjct: 89 IGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLP 148
Query: 254 VNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFV-VLPTGDVW 312
N + GG F CKV SD +P IQW+K VE ++ S G ++ VL V
Sbjct: 149 ANASTVVGGDVEFVCKVYSDAQPHIQWIKHVE-----KNGSKYGPDGLPYLKVLKAAGV- 202
Query: 313 SRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSA 372
+ L I +DAG Y CL N++G SF SA+LTVLP P
Sbjct: 203 -NTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAP-------GREKEI 254
Query: 373 TSLPWPVVIGIPAGAVFILGTLLLWLCQAQKKPCTPAP 410
T+ P + I I VF++ +++ + + K T P
Sbjct: 255 TASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKP 292
Score = 50.8 bits (120), Expect = 3e-06
Identities = 50/202 (24%), Positives = 73/202 (36%), Gaps = 45/202 (22%)
Query: 46 TVRLQCPVEGDPPPLTMWTKDGRTIHS----GWSRFRVLPQGLKVKQVEREDAGVYVCKA 101
TV+ +CP G+P P W K+G+ G + R L ++ V D G Y C
Sbjct: 59 TVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVV 118
Query: 102 TNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIA 161
N +GS++ Y L V++ SP + L G AS
Sbjct: 119 ENEYGSINHTYHLDVVER-SPHRPIL-----QAGLPANAS-------------------- 152
Query: 162 RPVGSSVRLKCVASGHPRPDITWMKDDQ---------------ALTRPEAAEPRKKKWTL 206
VG V C +P I W+K + L K+ L
Sbjct: 153 TVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVL 212
Query: 207 SLKNLRPEDSGKYTCRVSNRAG 228
++N+ ED+G+YTC N G
Sbjct: 213 YIRNVTFEDAGEYTCLAGNSIG 234
Score = 29.3 bits (64), Expect = 8.8
Identities = 29/99 (29%), Positives = 36/99 (36%), Gaps = 18/99 (18%)
Query: 43 LGRTVRLQCPVEGDPPPLTMWTKDGRTIHS-----GWSRFRVLPQG-----------LKV 86
+G V C V D P W K S G +VL L +
Sbjct: 155 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 214
Query: 87 KQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKE 125
+ V EDAG Y C A N G + L VL +PG+E
Sbjct: 215 RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLP--APGRE 251
>gi|222144237 fibroblast growth factor receptor 2 isoform 6
precursor [Homo sapiens]
Length = 706
Score = 147 bits (370), Expect = 3e-35
Identities = 89/278 (32%), Positives = 138/278 (49%), Gaps = 18/278 (6%)
Query: 137 EDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEA 196
ED + P +T KM +R+ A P ++V+ +C A G+P P + W+K+ + +
Sbjct: 29 EDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR 88
Query: 197 A---EPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHP 253
+ R + W+L ++++ P D G YTC V N G+IN TY +DV++R+ +P+L P
Sbjct: 89 IGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLP 148
Query: 254 VNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFV-VLPTGDVW 312
N + GG F CKV SD +P IQW+K VE ++ S G ++ VL V
Sbjct: 149 ANASTVVGGDVEFVCKVYSDAQPHIQWIKHVE-----KNGSKYGPDGLPYLKVLKAAGV- 202
Query: 313 SRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSA 372
+ L I +DAG Y CL N++G SF SA+LTVLP P
Sbjct: 203 -NTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAP-------GREKEI 254
Query: 373 TSLPWPVVIGIPAGAVFILGTLLLWLCQAQKKPCTPAP 410
T+ P + I I VF++ +++ + + K T P
Sbjct: 255 TASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKP 292
Score = 50.8 bits (120), Expect = 3e-06
Identities = 50/202 (24%), Positives = 73/202 (36%), Gaps = 45/202 (22%)
Query: 46 TVRLQCPVEGDPPPLTMWTKDGRTIHS----GWSRFRVLPQGLKVKQVEREDAGVYVCKA 101
TV+ +CP G+P P W K+G+ G + R L ++ V D G Y C
Sbjct: 59 TVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVV 118
Query: 102 TNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIA 161
N +GS++ Y L V++ SP + L G AS
Sbjct: 119 ENEYGSINHTYHLDVVER-SPHRPIL-----QAGLPANAS-------------------- 152
Query: 162 RPVGSSVRLKCVASGHPRPDITWMKDDQ---------------ALTRPEAAEPRKKKWTL 206
VG V C +P I W+K + L K+ L
Sbjct: 153 TVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVL 212
Query: 207 SLKNLRPEDSGKYTCRVSNRAG 228
++N+ ED+G+YTC N G
Sbjct: 213 YIRNVTFEDAGEYTCLAGNSIG 234
Score = 29.3 bits (64), Expect = 8.8
Identities = 29/99 (29%), Positives = 36/99 (36%), Gaps = 18/99 (18%)
Query: 43 LGRTVRLQCPVEGDPPPLTMWTKDGRTIHS-----GWSRFRVLPQG-----------LKV 86
+G V C V D P W K S G +VL L +
Sbjct: 155 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 214
Query: 87 KQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKE 125
+ V EDAG Y C A N G + L VL +PG+E
Sbjct: 215 RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLP--APGRE 251
>gi|222144244 fibroblast growth factor receptor 2 isoform 9
precursor [Homo sapiens]
Length = 680
Score = 145 bits (365), Expect = 1e-34
Identities = 95/308 (30%), Positives = 155/308 (50%), Gaps = 18/308 (5%)
Query: 107 SLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGS 166
SL + TL D IS G + D + + ++ + A P +T KM +R+ A P +
Sbjct: 26 SLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSNNKRA-PYWTNTEKMEKRLHAVPAAN 84
Query: 167 SVRLKCVASGHPRPDITWMKDDQALTRPEAA---EPRKKKWTLSLKNLRPEDSGKYTCRV 223
+V+ +C A G+P P + W+K+ + + + R + W+L ++++ P D G YTC V
Sbjct: 85 TVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVV 144
Query: 224 SNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKR 283
N G+IN TY +DV++R+ +P+L P N + GG F CKV SD +P IQW+K
Sbjct: 145 ENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKH 204
Query: 284 VEYGAEGRHNSTIDVGGQKFV-VLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGAN 342
VE ++ S G ++ VL + + S L + + DAG YIC +N
Sbjct: 205 VE-----KNGSKYGPDGLPYLKVLKHSGI----NSSNAEVLALFNVTEADAGEYICKVSN 255
Query: 343 TMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWLCQAQ 402
+G + +SA+LTVLP + PG T+ P + I I VF++ +++ + +
Sbjct: 256 YIGQANQSAWLTVLPKQQAPG----REKEITASPDYLEIAIYCIGVFLIACMVVTVILCR 311
Query: 403 KKPCTPAP 410
K T P
Sbjct: 312 MKNTTKKP 319
Score = 52.8 bits (125), Expect = 7e-07
Identities = 53/216 (24%), Positives = 83/216 (38%), Gaps = 43/216 (19%)
Query: 46 TVRLQCPVEGDPPPLTMWTKDGRTIHS----GWSRFRVLPQGLKVKQVEREDAGVYVCKA 101
TV+ +CP G+P P W K+G+ G + R L ++ V D G Y C
Sbjct: 85 TVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVV 144
Query: 102 TNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIA 161
N +GS++ Y L V++ SP + L G AS
Sbjct: 145 ENEYGSINHTYHLDVVER-SPHRPIL-----QAGLPANAS-------------------- 178
Query: 162 RPVGSSVRLKCVASGHPRPDITWMK---DDQALTRPEAAEPRK----------KKWTLSL 208
VG V C +P I W+K + + P+ K L+L
Sbjct: 179 TVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLAL 238
Query: 209 KNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRS 244
N+ D+G+Y C+VSN G N + + V+ + ++
Sbjct: 239 FNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQA 274
Score = 31.6 bits (70), Expect = 1.8
Identities = 29/100 (29%), Positives = 39/100 (39%), Gaps = 19/100 (19%)
Query: 43 LGRTVRLQCPVEGDPPPLTMWTK-----------DGRTI-----HSGWSRFRVLPQGLKV 86
+G V C V D P W K DG HSG + + L +
Sbjct: 181 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNA--EVLAL 238
Query: 87 KQVEREDAGVYVCKATNGFGSLSVNYTLVVL-DDISPGKE 125
V DAG Y+CK +N G + + L VL +PG+E
Sbjct: 239 FNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGRE 278
>gi|222144239 fibroblast growth factor receptor 2 isoform 7
precursor [Homo sapiens]
Length = 705
Score = 142 bits (359), Expect = 5e-34
Identities = 84/260 (32%), Positives = 139/260 (53%), Gaps = 14/260 (5%)
Query: 40 VARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVL-PQGLKVKQVEREDAGVYV 98
VA G ++ ++C ++ + WTKDG +H G + VL + L++K D+G+Y
Sbjct: 51 VAAPGESLEVRCLLKD--AAVISWTKDG--VHLGPNNRTVLIGEYLQIKGATPRDSGLYA 106
Query: 99 CKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRR 158
C A+ S + + + V D IS G + D + + ++ + A P +T KM +R
Sbjct: 107 CTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA-PYWTNTEKMEKR 165
Query: 159 VIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAA---EPRKKKWTLSLKNLRPED 215
+ A P ++V+ +C A G+P P + W+K+ + + + R + W+L ++++ P D
Sbjct: 166 LHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSD 225
Query: 216 SGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVK 275
G YTC V N G+IN TY +DV++R+ +P+L P N + GG F CKV SD +
Sbjct: 226 KGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQ 285
Query: 276 PVIQWLKRVE-----YGAEG 290
P IQW+K VE YG +G
Sbjct: 286 PHIQWIKHVEKNGSKYGPDG 305
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 140 bits (352), Expect = 4e-33
Identities = 84/245 (34%), Positives = 121/245 (49%), Gaps = 14/245 (5%)
Query: 119 DISPGKESLGPDSSSGGQE---DPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVAS 175
D P E D S +E D P +T P KM +++ A P +V+ KC +S
Sbjct: 31 DALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSS 90
Query: 176 GHPRPDITWMKDDQALT---RPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINA 232
G P P + W+K+ + R + R W++ + ++ P D G YTC V N G+IN
Sbjct: 91 GTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINH 150
Query: 233 TYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRH 292
TY++DV++R+ +P+L P N TV G F CKV SD +P IQWLK +E +
Sbjct: 151 TYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEV-----N 205
Query: 293 NSTIDVGGQKFV-VLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSA 351
S I +V +L T V + L + +DAG Y CL N++G S SA
Sbjct: 206 GSKIGPDNLPYVQILKTAGV--NTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSA 263
Query: 352 FLTVL 356
+LTVL
Sbjct: 264 WLTVL 268
Score = 65.1 bits (157), Expect = 1e-10
Identities = 65/273 (23%), Positives = 100/273 (36%), Gaps = 49/273 (17%)
Query: 20 PPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHS----GWS 75
P A P KM K+ +TV+ +CP G P P W K+G+ G
Sbjct: 59 PVAPYWTSPEKMEKKL---HAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGY 115
Query: 76 RFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGG 135
+ R + + V D G Y C N +GS++ Y L V++ SP + L
Sbjct: 116 KVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVER-SPHRPIL-------- 166
Query: 136 QEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDD------- 188
Q + +A +GS+V C P+P I W+K
Sbjct: 167 ---------------QAGLPANKTVA--LGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI 209
Query: 189 --------QALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQ 240
Q L K+ L L+N+ ED+G+YTC N G + + + V++
Sbjct: 210 GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE 269
Query: 241 RTRSKP-VLTGTHPVNTTVDFGGTTSFQCKVRS 272
+P V+T + + G C V S
Sbjct: 270 ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGS 302
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 138 bits (347), Expect = 1e-32
Identities = 83/247 (33%), Positives = 122/247 (49%), Gaps = 16/247 (6%)
Query: 119 DISPGKESLGPDSSSGGQEDPA-----SQQWARPRFTQPSKMRRRVIARPVGSSVRLKCV 173
D P E D S +E ++ P +T P KM +++ A P +V+ KC
Sbjct: 31 DALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP 90
Query: 174 ASGHPRPDITWMKDDQALT---RPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAI 230
+SG P P + W+K+ + R + R W++ + ++ P D G YTC V N G+I
Sbjct: 91 SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI 150
Query: 231 NATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEG 290
N TY++DV++R+ +P+L P N TV G F CKV SD +P IQWLK +E
Sbjct: 151 NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEV---- 206
Query: 291 RHNSTIDVGGQKFV-VLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFR 349
+ S I +V +L T V + L + +DAG Y CL N++G S
Sbjct: 207 -NGSKIGPDNLPYVQILKTAGV--NTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHH 263
Query: 350 SAFLTVL 356
SA+LTVL
Sbjct: 264 SAWLTVL 270
Score = 65.1 bits (157), Expect = 1e-10
Identities = 65/273 (23%), Positives = 100/273 (36%), Gaps = 49/273 (17%)
Query: 20 PPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHS----GWS 75
P A P KM K+ +TV+ +CP G P P W K+G+ G
Sbjct: 61 PVAPYWTSPEKMEKKL---HAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGY 117
Query: 76 RFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGG 135
+ R + + V D G Y C N +GS++ Y L V++ SP + L
Sbjct: 118 KVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVER-SPHRPIL-------- 168
Query: 136 QEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDD------- 188
Q + +A +GS+V C P+P I W+K
Sbjct: 169 ---------------QAGLPANKTVA--LGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI 211
Query: 189 --------QALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQ 240
Q L K+ L L+N+ ED+G+YTC N G + + + V++
Sbjct: 212 GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE 271
Query: 241 RTRSKP-VLTGTHPVNTTVDFGGTTSFQCKVRS 272
+P V+T + + G C V S
Sbjct: 272 ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGS 304
>gi|13186241 fibroblast growth factor receptor 1 isoform 6 precursor
[Homo sapiens]
Length = 300
Score = 120 bits (302), Expect = 2e-27
Identities = 62/173 (35%), Positives = 90/173 (52%), Gaps = 6/173 (3%)
Query: 119 DISPGKESLGPDSSSGGQE---DPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVAS 175
D P E D S +E D P +T P KM +++ A P +V+ KC +S
Sbjct: 31 DALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSS 90
Query: 176 GHPRPDITWMKDDQALT---RPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINA 232
G P P + W+K+ + R + R W++ + ++ P D G YTC V N G+IN
Sbjct: 91 GTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINH 150
Query: 233 TYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVE 285
TY++DV++R+ +P+L P N TV G F CKV SD +P IQWLK +E
Sbjct: 151 TYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIE 203
Score = 50.4 bits (119), Expect = 4e-06
Identities = 43/171 (25%), Positives = 64/171 (37%), Gaps = 33/171 (19%)
Query: 20 PPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTI----HSGWS 75
P A P KM K+ +TV+ +CP G P P W K+G+ G
Sbjct: 59 PVAPYWTSPEKMEKKL---HAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGY 115
Query: 76 RFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGG 135
+ R + + V D G Y C N +GS++ Y L V++ SP + L
Sbjct: 116 KVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVER-SPHRPIL-------- 166
Query: 136 QEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMK 186
Q + +A +GS+V C P+P I W+K
Sbjct: 167 ---------------QAGLPANKTVA--LGSNVEFMCKVYSDPQPHIQWLK 200
>gi|13186238 fibroblast growth factor receptor 1 isoform 5 precursor
[Homo sapiens]
Length = 302
Score = 119 bits (297), Expect = 8e-27
Identities = 61/175 (34%), Positives = 91/175 (52%), Gaps = 8/175 (4%)
Query: 119 DISPGKESLGPDSSSGGQEDPA-----SQQWARPRFTQPSKMRRRVIARPVGSSVRLKCV 173
D P E D S +E ++ P +T P KM +++ A P +V+ KC
Sbjct: 31 DALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP 90
Query: 174 ASGHPRPDITWMKDDQALT---RPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAI 230
+SG P P + W+K+ + R + R W++ + ++ P D G YTC V N G+I
Sbjct: 91 SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI 150
Query: 231 NATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVE 285
N TY++DV++R+ +P+L P N TV G F CKV SD +P IQWLK +E
Sbjct: 151 NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIE 205
Score = 50.4 bits (119), Expect = 4e-06
Identities = 43/171 (25%), Positives = 64/171 (37%), Gaps = 33/171 (19%)
Query: 20 PPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTI----HSGWS 75
P A P KM K+ +TV+ +CP G P P W K+G+ G
Sbjct: 61 PVAPYWTSPEKMEKKL---HAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGY 117
Query: 76 RFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGG 135
+ R + + V D G Y C N +GS++ Y L V++ SP + L
Sbjct: 118 KVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVER-SPHRPIL-------- 168
Query: 136 QEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMK 186
Q + +A +GS+V C P+P I W+K
Sbjct: 169 ---------------QAGLPANKTVA--LGSNVEFMCKVYSDPQPHIQWLK 202
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 107 bits (268), Expect = 2e-23
Identities = 105/375 (28%), Positives = 137/375 (36%), Gaps = 82/375 (21%)
Query: 29 PKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKVK 87
P + + +P G L C G P P W KDG+ + +F + P G L VK
Sbjct: 2755 PPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVK 2814
Query: 88 QVEREDAGVYVCKATNGFGSL--SVNYTLVVLDDIS--PGKESLGPDSSSGGQEDPASQQ 143
+E +DAG Y C A N G V+ T++VL + PG SL
Sbjct: 2815 NLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSL---------------- 2858
Query: 144 WARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKK 203
+G + L+C A G P P I W +D+ +T E +
Sbjct: 2859 -------------------RLGDRLWLRCAARGSPTPRIGWTVNDRPVT--EGVSEQDGG 2897
Query: 204 WTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGT 263
TL + EDSG Y C NR G A V V + PVL G GG+
Sbjct: 2898 STLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHV----KEAPVLQGEAFSYLVEPVGGS 2953
Query: 264 TSFQCKVRSDVKPVIQWLK--RVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLN 321
C VR D P I W+K G+ RH L G
Sbjct: 2954 IQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQ------------LQNG------------ 2989
Query: 322 KLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP----KP------PGPPVASSSS 371
L I R +DDAG Y CL N MG + + L + P +P G VA
Sbjct: 2990 SLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQ 3049
Query: 372 ATSLPWPVVIGIPAG 386
AT P P + + AG
Sbjct: 3050 ATGEPTPTIEWLQAG 3064
Score = 102 bits (255), Expect = 6e-22
Identities = 102/387 (26%), Positives = 142/387 (36%), Gaps = 71/387 (18%)
Query: 7 LLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKD 66
LL+L PP++LG +++V TV LQCP G+P P W ++
Sbjct: 1554 LLVLTPPVILGD-------------TEELVEEVTVNASSTVSLQCPALGNPVPTISWLQN 1600
Query: 67 GRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGK 124
G S R +VL G L+V E DA Y+C A N GS +TL V + P
Sbjct: 1601 GLPF-SPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRV--QVPPRI 1657
Query: 125 ESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITW 184
L + + + SSV L C HP P++TW
Sbjct: 1658 AGLDLEQ----------------------------VTAILNSSVSLPCDVHAHPNPEVTW 1689
Query: 185 MKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRS 244
KD QAL+ E TL L R DSG YTC N AG ++ V+
Sbjct: 1690 YKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAF 1749
Query: 245 KPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFV 304
+ G V G C+ + +P + W K + + + GGQ
Sbjct: 1750 RQAPRGPQDA-VLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALR-GGQ--- 1804
Query: 305 VLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGP 364
+L I A+ D G+Y C +N G + R+ LTV P P
Sbjct: 1805 -----------------RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENP 1847
Query: 365 PVASSSSATSLPWPV---VIGIPAGAV 388
+ S P + V G+PA V
Sbjct: 1848 KTETVSQVAGSPLVLTCDVSGVPAPTV 1874
Score = 99.8 bits (247), Expect = 5e-21
Identities = 88/320 (27%), Positives = 129/320 (40%), Gaps = 61/320 (19%)
Query: 42 RLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKA 101
RLG + L+C G P P WT + R + G S + L+ V RED+G YVC A
Sbjct: 2859 RLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSE-QDGGSTLQRAAVSREDSGTYVCWA 2917
Query: 102 TNGFG-SLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVI 160
N G + +V++ V +E P Q A +
Sbjct: 2918 ENRVGRTQAVSFVHV--------------------KEAPVLQGEAFS-----------YL 2946
Query: 161 ARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYT 220
PVG S++L CV G P PDI W+KD L R + + +L+++ +D+G+Y
Sbjct: 2947 VEPVGGSIQLDCVVRGDPVPDIHWIKDGLPL-RGSHLRHQLQNGSLTIRRTERDDAGRYQ 3005
Query: 221 CRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQW 280
C N G K VI +S PV P + TV G + +C+ + P I+W
Sbjct: 3006 CLAENEMGVA----KKVVILVLQSAPVFQ-VEPQDMTVRSGDDVALRCQATGEPTPTIEW 3060
Query: 281 LKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLG 340
L+ + R T LP G +W + DAG Y C+
Sbjct: 3061 LQAGQPLRASRRLRT----------LPDGSLW------------LENVETGDAGTYDCVA 3098
Query: 341 ANTMGYSFRSAFLTVLPDPK 360
N +G + AFL V +P+
Sbjct: 3099 HNLLGSATARAFLVVRGEPQ 3118
Score = 98.6 bits (244), Expect = 1e-20
Identities = 94/369 (25%), Positives = 161/369 (43%), Gaps = 48/369 (13%)
Query: 20 PPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRV 79
PP+ + P +A+ V ++ T+ L+C PPP W KDG+ + SR +V
Sbjct: 1350 PPSISKDDP--LAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPS-SRLQV 1406
Query: 80 LPQG--LKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQE 137
L +G L+++ + D+G Y+C ATN G ++ +++ + P + +G S++ E
Sbjct: 1407 LGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI--QVPPMFQKVGDFSAAF--E 1462
Query: 138 DPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAA 197
+ ++ AR T+ R ++ + L C + P PD+TW ++DQ L+ +
Sbjct: 1463 ILSREEEARGGVTE----YREIVEN---NPAYLYCDTNAIPPPDLTWYREDQPLSAGDEV 1515
Query: 198 EPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHP---V 254
+ L + +R E++G+Y+C+ SN G Y++ V+ + PV+ G
Sbjct: 1516 SVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVL----TPPVILGDTEELVE 1571
Query: 255 NTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSR 314
TV+ T S QC + P I WL+ N + VL G V
Sbjct: 1572 EVTVNASSTVSLQCPALGNPVPTISWLQ----------NGLPFSPSPRLQVLEDGQV--- 1618
Query: 315 PDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPG----PPVASSS 370
L ++ A DA Y+C+ N G + + L V P+ G A +
Sbjct: 1619 --------LQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILN 1670
Query: 371 SATSLPWPV 379
S+ SLP V
Sbjct: 1671 SSVSLPCDV 1679
Score = 97.1 bits (240), Expect = 3e-20
Identities = 89/325 (27%), Positives = 132/325 (40%), Gaps = 57/325 (17%)
Query: 28 PPKMADKVVPRQVARL-GRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--L 84
PP + ++ + + L G+T L C V G P P W KDGR + G + P G L
Sbjct: 1161 PPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARG-DAHHISPDGVLL 1219
Query: 85 KVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQW 144
+V Q AG Y C A N G + ++ L VL L P + GG ED A ++
Sbjct: 1220 QVLQANLSSAGHYSCIAANAVGEKTKHFQLSVL---------LAP-TILGGAEDSADEE- 1268
Query: 145 ARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKW 204
+ V + + L C A P P+ITWMKD +
Sbjct: 1269 ---------------VTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTH 1313
Query: 205 TLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVI---QRTRSKPVL-TGTHPVNTTVDF 260
L + N + ED+G+YTC V+N G Y V+V+ ++ P+ G V T V+
Sbjct: 1314 GLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVN- 1372
Query: 261 GGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYL 320
T + +C+ + P I+W K GQ V P+ + +G L
Sbjct: 1373 -STLTLECESWAVPPPTIRWYK----------------DGQP--VTPSSRLQVLGEGRLL 1413
Query: 321 NKLLITRARQDDAGMYICLGANTMG 345
I + D+G Y+C+ N G
Sbjct: 1414 Q---IQPTQVSDSGRYLCVATNVAG 1435
Score = 94.7 bits (234), Expect = 2e-19
Identities = 87/314 (27%), Positives = 122/314 (38%), Gaps = 61/314 (19%)
Query: 47 VRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKVKQVEREDAGVYVCKATNGF 105
V L C G P P W K+G + +G S +VLP G L++ EDAG Y+C A N
Sbjct: 2683 VLLPCEASGIPRPTITWQKEGLNVATGVST-QVLPGGQLRIAHASPEDAGNYLCIAKNSA 2741
Query: 106 GSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVG 165
GS LVV + P E+ PD S+ G
Sbjct: 2742 GSAMGKTRLVV--QVPPVIENGLPDLST-----------------------------TEG 2770
Query: 166 SSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSN 225
S L C A G P P+ITW KD Q ++ E + L +KNL +D+G YTC N
Sbjct: 2771 SHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAEN 2830
Query: 226 RAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVE 285
G + ++ PV T T P + ++ G +C R P I W
Sbjct: 2831 AVGRARRRVHLTIL----VLPVFT-TLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDR 2885
Query: 286 YGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMG 345
EG V + GS L + ++R +D+G Y+C N +G
Sbjct: 2886 PVTEG--------------------VSEQDGGSTLQRAAVSR---EDSGTYVCWAENRVG 2922
Query: 346 YSFRSAFLTVLPDP 359
+ +F+ V P
Sbjct: 2923 RTQAVSFVHVKEAP 2936
Score = 91.3 bits (225), Expect = 2e-18
Identities = 93/335 (27%), Positives = 127/335 (37%), Gaps = 64/335 (19%)
Query: 28 PPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKV 86
PP +AD V + V L C G P P W+K G + + S +RV P G L++
Sbjct: 2574 PPTIADDQTDFTVTMMAPVV-LTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEI 2632
Query: 87 KQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWAR 146
Q AG Y C A N G + L V Q P
Sbjct: 2633 GQALPIHAGRYTCSARNSAGVAHKHVFLTV-------------------QASPV------ 2667
Query: 147 PRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTL 206
+P R +A V L C ASG PRP ITW K+ + + + L
Sbjct: 2668 ---VKPLPSVVRAVAE---EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQV-LPGGQL 2720
Query: 207 SLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSF 266
+ + PED+G Y C N AG+ ++ V + PV+ P +T + G
Sbjct: 2721 RIAHASPEDAGNYLCIAKNSAGSAMGKTRLVV----QVPPVIENGLPDLSTTE-GSHAFL 2775
Query: 267 QCKVRSDVKPVIQWLK--RVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLL 324
CK R +P I W K + GAEG KF + P+G+ LL
Sbjct: 2776 PCKARGSPEPNITWDKDGQPVSGAEG-----------KFTIQPSGE------------LL 2812
Query: 325 ITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP 359
+ DAG Y C N +G + R LT+L P
Sbjct: 2813 VKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLP 2847
Score = 88.6 bits (218), Expect = 1e-17
Identities = 80/336 (23%), Positives = 125/336 (37%), Gaps = 57/336 (16%)
Query: 28 PPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLP--QGLK 85
PP++A + + A L +V L C V P P W KD + + G F +LP L+
Sbjct: 1654 PPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVF-LLPGTHTLQ 1712
Query: 86 VKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWA 145
+ + D+G+Y C+A N G + LV L + P
Sbjct: 1713 LGRARLSDSGMYTCEALNAAGR---DQKLVQLSVLVP----------------------- 1746
Query: 146 RPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWT 205
P F Q + + + VG L C P P +TW KD Q L + + +
Sbjct: 1747 -PAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQR 1805
Query: 206 LSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTS 265
L ++ + D G Y+C+VSN AG T+ + V + P + G
Sbjct: 1806 LEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTV----QVPPTFENPKTETVSQVAGSPLV 1861
Query: 266 FQCKVRSDVKPVIQWLK-RVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLL 324
C V P + WLK R+ + H + GG +L
Sbjct: 1862 LTCDVSGVPAPTVTWLKDRMPVESSAVH-GVVSRGG---------------------RLQ 1899
Query: 325 ITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPK 360
++R + AG Y C+ NT + + + VL P+
Sbjct: 1900 LSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPR 1935
Score = 88.6 bits (218), Expect = 1e-17
Identities = 86/320 (26%), Positives = 119/320 (37%), Gaps = 60/320 (18%)
Query: 43 LGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKVKQVEREDAGVYVCKA 101
+ +T L C +G P PL W KD + RF +LP+G L+++ V +DAG Y+C A
Sbjct: 2404 VNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLA 2463
Query: 102 TNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIA 161
+N GS L VL+ P PS + A
Sbjct: 2464 SNSAGSDRQGRDLRVLE----------------------------PPAIAPSPSNLTLTA 2495
Query: 162 RPVGSSVRLKCVASGHPRPDITWMKDDQAL--TRPEAAEPRKKKWTLSLKNLRPEDSGKY 219
+ L C ASG P+P + W KD Q L + A L L P+DS ++
Sbjct: 2496 H---TPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQF 2552
Query: 220 TCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQ 279
C VSN G + Y+V V P + TV C P +
Sbjct: 2553 ECVVSNEVGEAHRLYQVTV-----HVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVS 2607
Query: 280 WLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICL 339
W K GA+ + G + V P+G L I +A AG Y C
Sbjct: 2608 WSKA---GAQ------LGARGSGYRVSPSG------------ALEIGQALPIHAGRYTCS 2646
Query: 340 GANTMGYSFRSAFLTVLPDP 359
N+ G + + FLTV P
Sbjct: 2647 ARNSAGVAHKHVFLTVQASP 2666
Score = 87.4 bits (215), Expect = 3e-17
Identities = 92/378 (24%), Positives = 147/378 (38%), Gaps = 69/378 (18%)
Query: 28 PPKMADKVVPRQVARL-GRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGLKV 86
PP + D P +++ G + L C +G P P W KDG+ + +R + +V
Sbjct: 2211 PPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL----TRLENNSRATRV 2266
Query: 87 KQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWAR 146
+V DAG+Y C A + G++ ++ + V Q P
Sbjct: 2267 LRVR--DAGLYTCLAESPAGAIEKSFRVRV-------------------QAPPNIVGPRG 2305
Query: 147 PRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTL 206
PRF V+ G V L+C P P ITW +D L + ++ L
Sbjct: 2306 PRF---------VVGLAPGQLV-LECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFL 2355
Query: 207 SLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVL-TGTHPVNTTVDFGGTTS 265
L+ L DSG Y+C N AG+ + ++V++ + P + +G VN +V+ T
Sbjct: 2356 QLQALSTADSGDYSCTARNAAGSTSVAFRVEI----HTVPTIRSGPPAVNVSVN--QTAL 2409
Query: 266 FQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLI 325
C+ P++ W K +D +F +LP G + +P
Sbjct: 2410 LPCQADGVPAPLVSWRK---------DRVPLDPRSPRFEILPEGSLRIQP---------- 2450
Query: 326 TRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIPA 385
DAG Y+CL +N+ G + L VL P +A S S +L +P
Sbjct: 2451 --VLAQDAGHYLCLASNSAGSDRQGRDLRVLEP-----PAIAPSPSNLTLTAHTPALLPC 2503
Query: 386 GAVFILGTLLLWLCQAQK 403
A L++W QK
Sbjct: 2504 EASGSPKPLVVWWKDGQK 2521
Score = 86.3 bits (212), Expect = 6e-17
Identities = 95/370 (25%), Positives = 143/370 (38%), Gaps = 77/370 (20%)
Query: 28 PPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--LK 85
PP + V + V +V L+C G PPP W K + + S W V G L+
Sbjct: 603 PPNIEPGPVNKAVLE-NASVTLECLASGVPPPDVSWFKGHQPV-SSWMGVTVSVDGRVLR 660
Query: 86 VKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWA 145
++Q + DAG Y C A+N GS + Y L V
Sbjct: 661 IEQAQLSDAGSYRCVASNVAGSTELRYGLRVN---------------------------V 693
Query: 146 RPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKW- 204
PR T P + V+ V + VRL C A+G P P + W+KD ++ A P + +
Sbjct: 694 PPRITLPPSLPGPVL---VNTPVRLTCNATGAPSPTLMWLKDGNPVS--PAGTPGLQVFP 748
Query: 205 ---TLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFG 261
L+L + R DSG+Y+C + G + DV+ + P + G +N +V
Sbjct: 749 GGRVLTLASARASDSGRYSCVAVSAVG----EDRQDVVLQVHMPPSILG-EELNVSVVAN 803
Query: 262 GTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLN 321
+ + +C+ + PV+ W K +GR + P V D + L
Sbjct: 804 ESVALECQSHAMPPPVLSWWK------DGR------------PLEPRPGVHLSADKALLQ 845
Query: 322 KLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPP-----------GPPVASSS 370
+ RA DAG Y C N G+S + L V P P G P S
Sbjct: 846 ---VDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTRLSC 902
Query: 371 SATSLPWPVV 380
+P+P +
Sbjct: 903 ECRGVPFPKI 912
Score = 84.7 bits (208), Expect = 2e-16
Identities = 84/355 (23%), Positives = 132/355 (37%), Gaps = 67/355 (18%)
Query: 7 LLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKD 66
L +L+PP L+G P + A L + L C G PPP W +
Sbjct: 1062 LSVLVPPELIGDLDP--------------LTNITAALHSPLTLLCEAMGIPPPAIRWFRG 1107
Query: 67 GRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGK 124
+ G + +L G LK+ Q + +D+G+Y C A+N G N+++ VL S
Sbjct: 1108 EEPVSPGEDTY-LLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIEN 1166
Query: 125 ESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITW 184
E L VI G + L C +GHP+P +TW
Sbjct: 1167 EDL-----------------------------EEVIKVLDGQTAHLMCNVTGHPQPKLTW 1197
Query: 185 MKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRS 244
KD + L R +A L + +G Y+C +N G +++ V+
Sbjct: 1198 FKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTI 1257
Query: 245 KPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFV 304
+ TV S C+ + P I W+K GA + I
Sbjct: 1258 LGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKD---GAPFEASRNIQ------- 1307
Query: 305 VLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP 359
+LP + L I A+++DAG Y C+ N +G + ++ + VL P
Sbjct: 1308 LLPG-----------THGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPP 1351
Score = 83.6 bits (205), Expect = 4e-16
Identities = 84/359 (23%), Positives = 133/359 (37%), Gaps = 69/359 (19%)
Query: 49 LQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCKATNGFG 106
L C PPP W ++ + + +G VL G L++ V E+AG Y CKA+N G
Sbjct: 1488 LYCDTNAIPPPDLTWYREDQPLSAG-DEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVG 1546
Query: 107 SLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGS 166
++Y L+VL P G E+ + + S
Sbjct: 1547 EDWLHYELLVLT----------PPVILGDTEELVEE-----------------VTVNASS 1579
Query: 167 SVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNR 226
+V L+C A G+P P I+W+++ + + + L + D+ Y C N+
Sbjct: 1580 TVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQ 1639
Query: 227 AGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEY 286
AG+ + + R + P + G T + S C V + P + W K
Sbjct: 1640 AGSAEKLFTL----RVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYK---- 1691
Query: 287 GAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGY 346
+ + +G + F++ T + L + RAR D+GMY C N G
Sbjct: 1692 -----DSQALSLGEEVFLLPGT------------HTLQLGRARLSDSGMYTCEALNAAGR 1734
Query: 347 SFRSAFLTVLPDP----KPPGPPVA----------SSSSATSLPWPVVIGIPAGAVFIL 391
+ L+VL P P GP A S +LP P V G +L
Sbjct: 1735 DQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVL 1793
Score = 82.0 bits (201), Expect = 1e-15
Identities = 102/410 (24%), Positives = 149/410 (36%), Gaps = 85/410 (20%)
Query: 20 PPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWS-RFR 78
P A R PP VV VA L +C G PPP W +DG+ + + + +
Sbjct: 974 PQIAGPREPPTQVS-VVQDGVATL------ECNATGKPPPTVTWERDGQPVGAELGLQLQ 1026
Query: 79 VLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQED 138
Q L V++ + G Y C A N G + L VL + P+ G D
Sbjct: 1027 NQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVL---------VPPELI--GDLD 1075
Query: 139 PASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAE 198
P + I + S + L C A G P P I W + ++ ++ E
Sbjct: 1076 PLTN-----------------ITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTY 1118
Query: 199 PRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTV 258
W L + + +DSG Y+C SN AG + V+V+ + V +
Sbjct: 1119 LLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIEN--EDLEEVIKVL 1176
Query: 259 DFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWS-RPDG 317
D G T C V +P + W K +GR L GD PDG
Sbjct: 1177 D-GQTAHLMCNVTGHPQPKLTWFK------DGR-------------PLARGDAHHISPDG 1216
Query: 318 SYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPG-------------- 363
L + +A AG Y C+ AN +G + L+VL P G
Sbjct: 1217 VLLQ---VLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTV 1273
Query: 364 -PPVASSSSATSLPWPVVIGIPAGAVF--------ILGTLLLWLCQAQKK 404
P++ A + P P + + GA F + GT L + AQK+
Sbjct: 1274 NNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKE 1323
Score = 79.3 bits (194), Expect = 7e-15
Identities = 74/282 (26%), Positives = 106/282 (37%), Gaps = 58/282 (20%)
Query: 80 LPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDP 139
LP L++++V+ D G+Y C ATN G L VL
Sbjct: 564 LPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLV--------------------- 602
Query: 140 ASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEP 199
P +P + + V+ +SV L+C+ASG P PD++W K Q ++
Sbjct: 603 -------PPNIEPGPVNKAVLEN---ASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTV 652
Query: 200 RKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATY--KVDVIQRTRSKPVLTGTHPVNTT 257
L ++ + D+G Y C SN AG+ Y +V+V R P L G VNT
Sbjct: 653 SVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTP 712
Query: 258 VDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDG 317
V C P + WLK +G N G V P G V
Sbjct: 713 V------RLTCNATGAPSPTLMWLK------DG--NPVSPAGTPGLQVFPGGRV------ 752
Query: 318 SYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP 359
L + AR D+G Y C+ + +G + L V P
Sbjct: 753 -----LTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPP 789
Score = 79.0 bits (193), Expect = 1e-14
Identities = 81/329 (24%), Positives = 124/329 (37%), Gaps = 71/329 (21%)
Query: 40 VARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG----LKVKQVEREDAG 95
V+R G V + CPV G PP W KDG + R L G L++ +V+ DAG
Sbjct: 2042 VSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQ---RTLLHGSGHTLRISKVQLADAG 2098
Query: 96 VYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKM 155
++ C A + G N+TL V P +P +
Sbjct: 2099 IFTCVAASPAGVADRNFTLQV----------------------------QVPPVLEPVEF 2130
Query: 156 RRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPED 215
+ V+ GS V L C A G P P ++WMKD + P ++ ++ +L L+ + D
Sbjct: 2131 QNDVVVVR-GSLVELPCEARGVPLPLVSWMKDGE----PLLSQSLEQGPSLQLEAVGAGD 2185
Query: 216 SGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVK 275
SG Y+C + AG +++ V++ + P ++ G C + +
Sbjct: 2186 SGTYSCVAVSEAGEARRHFQLTVMEPPH---IEDSGQPTELSLTPGAPMELLCDAQGTPQ 2242
Query: 276 PVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGM 335
P I W K GQ L +R + R R DAG+
Sbjct: 2243 PNITWHK----------------DGQALTRLENNSRATR----------VLRVR--DAGL 2274
Query: 336 YICLGANTMGYSFRSAFLTVLPDPKPPGP 364
Y CL + G +S + V P GP
Sbjct: 2275 YTCLAESPAGAIEKSFRVRVQAPPNIVGP 2303
Score = 78.2 bits (191), Expect = 2e-14
Identities = 75/323 (23%), Positives = 125/323 (38%), Gaps = 58/323 (17%)
Query: 42 RLGRTVRLQCPVEGDPPPLTMWTKDGRTIH---SGWSRFRVLPQGLKVKQVEREDAGVYV 98
R G RL C G P P W KDG+ + +G + + L + Q + G Y
Sbjct: 893 REGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYT 952
Query: 99 CKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRR 158
C+ +N G+ S + L E P +G +E P TQ S ++
Sbjct: 953 CECSNVVGNSSQDLQL----------EVHVPPQIAGPREPP----------TQVSVVQDG 992
Query: 159 VIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGK 218
V L+C A+G P P +TW +D Q + + + + +L ++ + +G+
Sbjct: 993 VAT--------LECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGR 1044
Query: 219 YTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHP--VNTTVDFGGTTSFQCKVRSDVKP 276
Y+C N AG +++ V+ P L G N T + C+ P
Sbjct: 1045 YSCVAENLAGRAERKFELSVL----VPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPP 1100
Query: 277 VIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMY 336
I+W + E + G + G W L +T+ ++ D+G+Y
Sbjct: 1101 AIRWFRGEEPVSPGEDTYLLAGG------------W---------MLKMTQTQEQDSGLY 1139
Query: 337 ICLGANTMGYSFRSAFLTVLPDP 359
CL +N G + R+ + VL P
Sbjct: 1140 SCLASNEAGEARRNFSVEVLVPP 1162
Score = 77.0 bits (188), Expect = 4e-14
Identities = 82/351 (23%), Positives = 125/351 (35%), Gaps = 73/351 (20%)
Query: 44 GRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWS---RFRVLPQGLKVKQVEREDAGVYVCK 100
G+ VRL C +G PPP W KDG + RF + L +K + DAG Y C
Sbjct: 1950 GQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCV 2009
Query: 101 ATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVI 160
A N G + +T+ VL P G D S ++
Sbjct: 2010 AHNPAGEDARLHTVNVL---VPPTIKQGADGSG------------------------TLV 2042
Query: 161 ARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYT 220
+RP G V + C G P ++W+KD L + TL + ++ D+G +T
Sbjct: 2043 SRP-GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFT 2101
Query: 221 CRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDF-GGTTSFQCKVRSDVKPVIQ 279
C ++ AG + + + V + PVL N V G C+ R P++
Sbjct: 2102 CVAASPAGVADRNFTLQV----QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVS 2157
Query: 280 WLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICL 339
W+K E + +++ G L + D+G Y C+
Sbjct: 2158 WMK----DGEPLLSQSLEQG---------------------PSLQLEAVGAGDSGTYSCV 2192
Query: 340 GANTMGYSFRSAFLTVLPDPK------------PPGPPVASSSSATSLPWP 378
+ G + R LTV+ P PG P+ A P P
Sbjct: 2193 AVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQP 2243
Score = 74.7 bits (182), Expect = 2e-13
Identities = 98/410 (23%), Positives = 147/410 (35%), Gaps = 69/410 (16%)
Query: 43 LGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCK 100
+G+ + L C G P P W ++GR + +V QG L + VE + +G++ C+
Sbjct: 421 VGQPLELPCQASGSPVPTIQWLQNGRPAEE-LAGVQVASQGTTLHIDHVELDHSGLFACQ 479
Query: 101 ATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVI 160
ATN G+ + V + +PG + G E +S P P +
Sbjct: 480 ATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSF----PAACDPP------V 529
Query: 161 ARPVGSSVRLKCVASGHPRPDIT--WMKDDQALTRPEAAEPRKK-KWTLSLKNLRPEDSG 217
R G+ HP+P + W P L ++ + D G
Sbjct: 530 HRGWGA----------HPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEG 579
Query: 218 KYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPV 277
YTC +N AG + V+ +P PVN V + + +C P
Sbjct: 580 IYTCAATNLAGESKREVALKVLVPPNIEP-----GPVNKAVLENASVTLECLASGVPPPD 634
Query: 278 IQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYI 337
+ W K + T+ V G+ L I +A+ DAG Y
Sbjct: 635 VSWFKGHQ-PVSSWMGVTVSVDGRV--------------------LRIEQAQLSDAGSYR 673
Query: 338 CLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIP----AGAVFILGT 393
C+ +N G + L V P+ PP SLP PV++ P A
Sbjct: 674 CVASNVAGSTELRYGLRVNVPPRITLPP--------SLPGPVLVNTPVRLTCNATGAPSP 725
Query: 394 LLLWLCQAQKKPCTPAPAPPL---PGHRPPGTARDRSGDKDLPSLAALSA 440
L+WL P +PA P L PG R A R+ D S A+SA
Sbjct: 726 TLMWL--KDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSA 773
Score = 74.3 bits (181), Expect = 2e-13
Identities = 78/302 (25%), Positives = 110/302 (36%), Gaps = 57/302 (18%)
Query: 47 VRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG---LKVKQVEREDAGVYVCKATN 103
V+L C G P P W KDG + + S V +G L++ + + DAGVY CKA+N
Sbjct: 238 VQLLCEARGVPTPNITWFKDGALLPT--STKVVYTRGGRQLQLGRAQSSDAGVYTCKASN 295
Query: 104 GFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARP 163
G+ L V + P E G R V+
Sbjct: 296 AVGAAEKATRLDVY--VPPTIEGAGG--------------------------RPYVVKAV 327
Query: 164 VGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRV 223
G V L+CVA GHP P ++W + + + L L++ SG Y+C
Sbjct: 328 AGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVA 387
Query: 224 SNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKR 283
S+ AG Y V+V Q V G V T V G C+ P IQWL+
Sbjct: 388 SSPAGEAVLQYSVEV-QVPPQLLVAEGLGQVTTIV--GQPLELPCQASGSPVPTIQWLQN 444
Query: 284 VEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANT 343
G + + V Q G+ L+ I D +G++ C N
Sbjct: 445 ---GRPAEELAGVQVASQ---------------GTTLH---IDHVELDHSGLFACQATNE 483
Query: 344 MG 345
G
Sbjct: 484 AG 485
Score = 73.6 bits (179), Expect = 4e-13
Identities = 91/402 (22%), Positives = 145/402 (36%), Gaps = 90/402 (22%)
Query: 7 LLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKD 66
L +LL P +LG G AD+ V + + L C P P W KD
Sbjct: 1249 LSVLLAPTILG---------GAEDSADEEV---TVTVNNPISLICEALAFPSPNITWMKD 1296
Query: 67 GRTIHSGWSRFRVLP--QGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGK 124
G + ++LP GL++ ++EDAG Y C TN G NY + VL I P
Sbjct: 1297 GAPFEAS-RNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVL--IPP-- 1351
Query: 125 ESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITW 184
S ++DP ++ + + V S++ L+C + P P I W
Sbjct: 1352 --------SISKDDPLAEVGVKE------------VKTKVNSTLTLECESWAVPPPTIRW 1391
Query: 185 MKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRS 244
KD Q +T + + L ++ + DSG+Y C +N AG + + V + +
Sbjct: 1392 YKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI----QV 1447
Query: 245 KPVLTGTHPVNTTVDF--------GGTTSFQ-----------CKVRSDVKPVIQWLKRVE 285
P+ + + GG T ++ C + P + W + +
Sbjct: 1448 PPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQ 1507
Query: 286 YGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMG 345
+ G S + G L I R ++AG Y C +N +G
Sbjct: 1508 PLSAGDEVSVLQGG---------------------RVLQIPLVRAENAGRYSCKASNEVG 1546
Query: 346 YSFRSAFLTVLPDPKPPGPP-------VASSSSATSLPWPVV 380
+ L VL P G ++SS SL P +
Sbjct: 1547 EDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPAL 1588
Score = 72.8 bits (177), Expect = 7e-13
Identities = 98/404 (24%), Positives = 139/404 (34%), Gaps = 92/404 (22%)
Query: 7 LLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKD 66
LL+L PP +LGA AA+ +A G V LQC G P P WTKD
Sbjct: 119 LLVLTPPSVLGA----GAAQEVLGLA-----------GADVELQCWTSGVPTPQVEWTKD 163
Query: 67 GRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGK 124
+ + G +V G L++ D G Y C A + G + ++ L V
Sbjct: 164 RQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVH------- 216
Query: 125 ESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITW 184
P + G E +A V+L C A G P P+ITW
Sbjct: 217 ---APPTIWGSNETGE-------------------VAVMEDHLVQLLCEARGVPTPNITW 254
Query: 185 MKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRS 244
KD L + L L + D+G YTC+ SN GA ++DV
Sbjct: 255 FKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY----V 310
Query: 245 KPVLTGT--HPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQK 302
P + G P G + +C R P + W H+ + V
Sbjct: 311 PPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSW-----------HHEGLPVAESN 359
Query: 303 FVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPP 362
L T DGS L + + +G+Y C+ ++ P
Sbjct: 360 ESRLET-------DGSVLR---LESPGEASSGLYSCVASS------------------PA 391
Query: 363 GPPVASSSSATSLPWPVVIGIPAGAV-FILGTLLLWLCQAQKKP 405
G V S +P +++ G V I+G L CQA P
Sbjct: 392 GEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSP 435
Score = 72.0 bits (175), Expect = 1e-12
Identities = 80/340 (23%), Positives = 134/340 (39%), Gaps = 76/340 (22%)
Query: 44 GRTVRLQCPVEGDPPPLTMWTKDGRTIHS--GWSRF------------RVLPQG--LKVK 87
G+++ L+C G P P +W KD + + GW+ + R+L +G L
Sbjct: 33 GQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFP 92
Query: 88 QVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARP 147
+++ D+G+Y C+A N G+ ++ L+VL P S G A+Q+
Sbjct: 93 RIQEGDSGLYSCRAENQAGTAQRDFHLLVLT----------PPSVLGA---GAAQE---- 135
Query: 148 RFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQ-ALTRPEAAEPRKKKWTL 206
+ G+ V L+C SG P P + W KD Q L + ++ L
Sbjct: 136 ------------VLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVL 183
Query: 207 SLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPV-NTTVDFGGTTS 265
+ D G+Y C + AG +++ R + P + G++ V
Sbjct: 184 RITGSHVGDEGRYQCVAFSPAGQQARDFQL----RVHAPPTIWGSNETGEVAVMEDHLVQ 239
Query: 266 FQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGD--VWSRPDGSYLNKL 323
C+ R P I W K +G +LPT V++R +L
Sbjct: 240 LLCEARGVPTPNITWFK------DG-------------ALLPTSTKVVYTRGG----RQL 276
Query: 324 LITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPG 363
+ RA+ DAG+Y C +N +G + ++ L V P G
Sbjct: 277 QLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEG 316
Score = 67.0 bits (162), Expect = 4e-11
Identities = 81/321 (25%), Positives = 111/321 (34%), Gaps = 57/321 (17%)
Query: 47 VRLQCPVEGDPPPLTMWTKDGRTIH-SGWSRFRVLPQG--LKVKQVEREDAGVYVCKATN 103
VRL C G P P MW KDG + +G +V P G L + D+G Y C A +
Sbjct: 713 VRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVS 772
Query: 104 GFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARP 163
G + L V P S G ++ V+A
Sbjct: 773 AVGEDRQDVVLQVHM----------PPSILG------------------EELNVSVVAN- 803
Query: 164 VGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRV 223
SV L+C + P P ++W KD + L K L + D+G YTC
Sbjct: 804 --ESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEA 861
Query: 224 SNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKR 283
N+AG Y ++V PV TV G T C+ R P I W K
Sbjct: 862 LNQAGHSEKHYNLNV----WVAPVFPLRESHTLTVREGHPTRLSCECRGVPFPKISWRK- 916
Query: 284 VEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANT 343
GQ LP + + L + +A+ G Y C +N
Sbjct: 917 ---------------DGQP---LPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNV 958
Query: 344 MGYSFRSAFLTVLPDPKPPGP 364
+G S + L V P+ GP
Sbjct: 959 VGNSSQDLQLEVHVPPQIAGP 979
Score = 53.5 bits (127), Expect = 4e-07
Identities = 53/220 (24%), Positives = 79/220 (35%), Gaps = 40/220 (18%)
Query: 156 RRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRP--EAAEPRKKKW--------- 204
R+ ++ G S+ L+C A+G P P+I W+KD Q + P A W
Sbjct: 24 RKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLL 83
Query: 205 ----TLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDF 260
+L ++ DSG Y+CR N+AG + + V+ + P + G +
Sbjct: 84 DEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVL----TPPSVLGAGAAQEVLGL 139
Query: 261 GGT-TSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSY 319
G QC P ++W K + GG V G V
Sbjct: 140 AGADVELQCWTSGVPTPQVEWTK---------DRQPVLPGGPHLQVQEDGQV-------- 182
Query: 320 LNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP 359
L IT + D G Y C+ + G R L V P
Sbjct: 183 ---LRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPP 219
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 107 bits (267), Expect = 3e-23
Identities = 105/375 (28%), Positives = 137/375 (36%), Gaps = 82/375 (21%)
Query: 29 PKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKVK 87
P + + +P G L C G P P W KDG+ + +F + P G L VK
Sbjct: 2846 PPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVK 2905
Query: 88 QVEREDAGVYVCKATNGFGSL--SVNYTLVVLDDIS--PGKESLGPDSSSGGQEDPASQQ 143
+E +DAG Y C A N G V+ T++VL + PG SL
Sbjct: 2906 NLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSL---------------- 2949
Query: 144 WARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKK 203
+G + L+C A G P P I W +D+ +T E +
Sbjct: 2950 -------------------RLGDRLWLRCAARGSPTPRIGWTVNDRPVT--EGVSEQDGG 2988
Query: 204 WTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGT 263
TL + EDSG Y C NR G A V V + PVL G GG+
Sbjct: 2989 STLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHV----KEAPVLQGEAFSYLVEPVGGS 3044
Query: 264 TSFQCKVRSDVKPVIQWLK--RVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLN 321
C VR D P I W+K G+ RH L G
Sbjct: 3045 IQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQ------------LQNG------------ 3080
Query: 322 KLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP----KP------PGPPVASSSS 371
L I R +DDAG Y CL N MG + + L + P +P G VA
Sbjct: 3081 SLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQ 3140
Query: 372 ATSLPWPVVIGIPAG 386
AT P P + + AG
Sbjct: 3141 ATGEPTPTIEWLQAG 3155
Score = 102 bits (255), Expect = 6e-22
Identities = 102/387 (26%), Positives = 142/387 (36%), Gaps = 71/387 (18%)
Query: 7 LLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKD 66
LL+L PP++LG +++V TV LQCP G+P P W ++
Sbjct: 1645 LLVLTPPVILGD-------------TEELVEEVTVNASSTVSLQCPALGNPVPTISWLQN 1691
Query: 67 GRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGK 124
G S R +VL G L+V E DA Y+C A N GS +TL V + P
Sbjct: 1692 GLPF-SPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRV--QVPPRI 1748
Query: 125 ESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITW 184
L + + + SSV L C HP P++TW
Sbjct: 1749 AGLDLEQ----------------------------VTAILNSSVSLPCDVHAHPNPEVTW 1780
Query: 185 MKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRS 244
KD QAL+ E TL L R DSG YTC N AG ++ V+
Sbjct: 1781 YKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAF 1840
Query: 245 KPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFV 304
+ G V G C+ + +P + W K + + + GGQ
Sbjct: 1841 RQAPRGPQDA-VLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALR-GGQ--- 1895
Query: 305 VLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGP 364
+L I A+ D G+Y C +N G + R+ LTV P P
Sbjct: 1896 -----------------RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENP 1938
Query: 365 PVASSSSATSLPWPV---VIGIPAGAV 388
+ S P + V G+PA V
Sbjct: 1939 KTETVSQVAGSPLVLTCDVSGVPAPTV 1965
Score = 98.6 bits (244), Expect = 1e-20
Identities = 88/320 (27%), Positives = 128/320 (40%), Gaps = 61/320 (19%)
Query: 42 RLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKA 101
RLG + L+C G P P WT + R + G S + L+ V RED+G YVC A
Sbjct: 2950 RLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSE-QDGGSTLQRAAVSREDSGTYVCWA 3008
Query: 102 TNGFG-SLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVI 160
N G + +V++ V +E P Q A +
Sbjct: 3009 ENRVGRTQAVSFVHV--------------------KEAPVLQGEAFS-----------YL 3037
Query: 161 ARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYT 220
PVG S++L CV G P PDI W+KD L R + + +L++ +D+G+Y
Sbjct: 3038 VEPVGGSIQLDCVVRGDPVPDIHWIKDGLPL-RGSHLRHQLQNGSLTIHRTERDDAGRYQ 3096
Query: 221 CRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQW 280
C N G K VI +S PV P + TV G + +C+ + P I+W
Sbjct: 3097 CLAENEMGVA----KKVVILVLQSAPVFQ-VEPQDMTVRSGDDVALRCQATGEPTPTIEW 3151
Query: 281 LKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLG 340
L+ + R T LP G +W + DAG Y C+
Sbjct: 3152 LQAGQPLRASRRLRT----------LPDGSLW------------LENVETGDAGTYDCVA 3189
Query: 341 ANTMGYSFRSAFLTVLPDPK 360
N +G + AFL V +P+
Sbjct: 3190 HNLLGSATARAFLVVRGEPQ 3209
Score = 97.1 bits (240), Expect = 3e-20
Identities = 93/369 (25%), Positives = 160/369 (43%), Gaps = 48/369 (13%)
Query: 20 PPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRV 79
PP+ + P + + V ++ T+ L+C PPP W KDG+ + SR +V
Sbjct: 1441 PPSISKDDP--LGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPS-SRLQV 1497
Query: 80 LPQG--LKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQE 137
L +G L+++ + D+G Y+C ATN G ++ +++ + P + +G S++ E
Sbjct: 1498 LGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI--QVPPMFQKVGDFSAAF--E 1553
Query: 138 DPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAA 197
+ ++ AR T+ R ++ + L C + P PD+TW ++DQ L+ +
Sbjct: 1554 ILSREEEARGGVTE----YREIVEN---NPAYLYCDTNAIPPPDLTWYREDQPLSAGDEV 1606
Query: 198 EPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHP---V 254
+ L + +R E++G+Y+C+ SN G Y++ V+ + PV+ G
Sbjct: 1607 SVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVL----TPPVILGDTEELVE 1662
Query: 255 NTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSR 314
TV+ T S QC + P I WL+ N + VL G V
Sbjct: 1663 EVTVNASSTVSLQCPALGNPVPTISWLQ----------NGLPFSPSPRLQVLEDGQV--- 1709
Query: 315 PDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPG----PPVASSS 370
L ++ A DA Y+C+ N G + + L V P+ G A +
Sbjct: 1710 --------LQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILN 1761
Query: 371 SATSLPWPV 379
S+ SLP V
Sbjct: 1762 SSVSLPCDV 1770
Score = 96.3 bits (238), Expect = 6e-20
Identities = 89/325 (27%), Positives = 132/325 (40%), Gaps = 57/325 (17%)
Query: 28 PPKMADKVVPRQVARL-GRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--L 84
PP + ++ + + L G+T L C V G P P W KDGR + G + P G L
Sbjct: 1252 PPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARG-DAHHISPDGVLL 1310
Query: 85 KVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQW 144
+V Q AG Y C A N G + ++ L VL L P + GG ED A ++
Sbjct: 1311 QVLQANLSSAGHYSCIAANAVGEKTKHFQLSVL---------LAP-TILGGAEDSADEE- 1359
Query: 145 ARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKW 204
+ V + + L C A P P+ITWMKD +
Sbjct: 1360 ---------------VTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTH 1404
Query: 205 TLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVI---QRTRSKPV-LTGTHPVNTTVDF 260
L + N + ED+G+YTC V+N G Y V+V+ ++ P+ G V T V+
Sbjct: 1405 GLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVN- 1463
Query: 261 GGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYL 320
T + +C+ + P I+W K GQ V P+ + +G L
Sbjct: 1464 -STLTLECESWAVPPPTIRWYK----------------DGQP--VTPSSRLQVLGEGRLL 1504
Query: 321 NKLLITRARQDDAGMYICLGANTMG 345
I + D+G Y+C+ N G
Sbjct: 1505 Q---IQPTQVSDSGRYLCVATNVAG 1526
Score = 94.7 bits (234), Expect = 2e-19
Identities = 87/314 (27%), Positives = 122/314 (38%), Gaps = 61/314 (19%)
Query: 47 VRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKVKQVEREDAGVYVCKATNGF 105
V L C G P P W K+G + +G S +VLP G L++ EDAG Y+C A N
Sbjct: 2774 VLLPCEASGIPRPTITWQKEGLNVATGVST-QVLPGGQLRIAHASPEDAGNYLCIAKNSA 2832
Query: 106 GSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVG 165
GS LVV + P E+ PD S+ G
Sbjct: 2833 GSAMGKTRLVV--QVPPVIENGLPDLST-----------------------------TEG 2861
Query: 166 SSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSN 225
S L C A G P P+ITW KD Q ++ E + L +KNL +D+G YTC N
Sbjct: 2862 SHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAEN 2921
Query: 226 RAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVE 285
G + ++ PV T T P + ++ G +C R P I W
Sbjct: 2922 AVGRARRRVHLTIL----VLPVFT-TLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDR 2976
Query: 286 YGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMG 345
EG V + GS L + ++R +D+G Y+C N +G
Sbjct: 2977 PVTEG--------------------VSEQDGGSTLQRAAVSR---EDSGTYVCWAENRVG 3013
Query: 346 YSFRSAFLTVLPDP 359
+ +F+ V P
Sbjct: 3014 RTQAVSFVHVKEAP 3027
Score = 91.3 bits (225), Expect = 2e-18
Identities = 93/335 (27%), Positives = 127/335 (37%), Gaps = 64/335 (19%)
Query: 28 PPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKV 86
PP +AD V + V L C G P P W+K G + + S +RV P G L++
Sbjct: 2665 PPTIADDQTDFTVTMMAPVV-LTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEI 2723
Query: 87 KQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWAR 146
Q AG Y C A N G + L V Q P
Sbjct: 2724 GQALPIHAGRYTCSARNSAGVAHKHVFLTV-------------------QASPV------ 2758
Query: 147 PRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTL 206
+P R +A V L C ASG PRP ITW K+ + + + L
Sbjct: 2759 ---VKPLPSVVRAVAE---EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQV-LPGGQL 2811
Query: 207 SLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSF 266
+ + PED+G Y C N AG+ ++ V + PV+ P +T + G
Sbjct: 2812 RIAHASPEDAGNYLCIAKNSAGSAMGKTRLVV----QVPPVIENGLPDLSTTE-GSHAFL 2866
Query: 267 QCKVRSDVKPVIQWLK--RVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLL 324
CK R +P I W K + GAEG KF + P+G+ LL
Sbjct: 2867 PCKARGSPEPNITWDKDGQPVSGAEG-----------KFTIQPSGE------------LL 2903
Query: 325 ITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP 359
+ DAG Y C N +G + R LT+L P
Sbjct: 2904 VKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLP 2938
Score = 88.6 bits (218), Expect = 1e-17
Identities = 80/336 (23%), Positives = 125/336 (37%), Gaps = 57/336 (16%)
Query: 28 PPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLP--QGLK 85
PP++A + + A L +V L C V P P W KD + + G F +LP L+
Sbjct: 1745 PPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVF-LLPGTHTLQ 1803
Query: 86 VKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWA 145
+ + D+G+Y C+A N G + LV L + P
Sbjct: 1804 LGRARLSDSGMYTCEALNAAGR---DQKLVQLSVLVP----------------------- 1837
Query: 146 RPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWT 205
P F Q + + + VG L C P P +TW KD Q L + + +
Sbjct: 1838 -PAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQR 1896
Query: 206 LSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTS 265
L ++ + D G Y+C+VSN AG T+ + V + P + G
Sbjct: 1897 LEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTV----QVPPTFENPKTETVSQVAGSPLV 1952
Query: 266 FQCKVRSDVKPVIQWLK-RVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLL 324
C V P + WLK R+ + H + GG +L
Sbjct: 1953 LTCDVSGVPAPTVTWLKDRMPVESSAVH-GVVSRGG---------------------RLQ 1990
Query: 325 ITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPK 360
++R + AG Y C+ NT + + + VL P+
Sbjct: 1991 LSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPR 2026
Score = 88.6 bits (218), Expect = 1e-17
Identities = 86/320 (26%), Positives = 119/320 (37%), Gaps = 60/320 (18%)
Query: 43 LGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKVKQVEREDAGVYVCKA 101
+ +T L C +G P PL W KD + RF +LP+G L+++ V +DAG Y+C A
Sbjct: 2495 VNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLA 2554
Query: 102 TNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIA 161
+N GS L VL+ P PS + A
Sbjct: 2555 SNSAGSDRQGRDLRVLE----------------------------PPAIAPSPSNLTLTA 2586
Query: 162 RPVGSSVRLKCVASGHPRPDITWMKDDQAL--TRPEAAEPRKKKWTLSLKNLRPEDSGKY 219
+ L C ASG P+P + W KD Q L + A L L P+DS ++
Sbjct: 2587 H---TPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQF 2643
Query: 220 TCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQ 279
C VSN G + Y+V V P + TV C P +
Sbjct: 2644 ECVVSNEVGEAHRLYQVTV-----HVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVS 2698
Query: 280 WLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICL 339
W K GA+ + G + V P+G L I +A AG Y C
Sbjct: 2699 WSKA---GAQ------LGARGSGYRVSPSG------------ALEIGQALPIHAGRYTCS 2737
Query: 340 GANTMGYSFRSAFLTVLPDP 359
N+ G + + FLTV P
Sbjct: 2738 ARNSAGVAHKHVFLTVQASP 2757
Score = 87.4 bits (215), Expect = 3e-17
Identities = 92/378 (24%), Positives = 147/378 (38%), Gaps = 69/378 (18%)
Query: 28 PPKMADKVVPRQVARL-GRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGLKV 86
PP + D P +++ G + L C +G P P W KDG+ + +R + +V
Sbjct: 2302 PPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL----TRLENNSRATRV 2357
Query: 87 KQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWAR 146
+V DAG+Y C A + G++ ++ + V Q P
Sbjct: 2358 LRVR--DAGLYTCLAESPAGAIEKSFRVRV-------------------QAPPNIVGPRG 2396
Query: 147 PRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTL 206
PRF V+ G V L+C P P ITW +D L + ++ L
Sbjct: 2397 PRF---------VVGLAPGQLV-LECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFL 2446
Query: 207 SLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVL-TGTHPVNTTVDFGGTTS 265
L+ L DSG Y+C N AG+ + ++V++ + P + +G VN +V+ T
Sbjct: 2447 QLQALSTADSGDYSCTARNAAGSTSVAFRVEI----HTVPTIRSGPPAVNVSVN--QTAL 2500
Query: 266 FQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLI 325
C+ P++ W K +D +F +LP G + +P
Sbjct: 2501 LPCQADGVPAPLVSWRK---------DRVPLDPRSPRFEILPEGSLRIQP---------- 2541
Query: 326 TRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIPA 385
DAG Y+CL +N+ G + L VL P +A S S +L +P
Sbjct: 2542 --VLAQDAGHYLCLASNSAGSDRQGRDLRVLEP-----PAIAPSPSNLTLTAHTPALLPC 2594
Query: 386 GAVFILGTLLLWLCQAQK 403
A L++W QK
Sbjct: 2595 EASGSPKPLVVWWKDGQK 2612
Score = 85.5 bits (210), Expect = 1e-16
Identities = 95/370 (25%), Positives = 143/370 (38%), Gaps = 77/370 (20%)
Query: 28 PPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--LK 85
PP + V + V +V L+C G PPP W K + + S W V G L+
Sbjct: 694 PPNIEPGPVNKAVLE-NASVTLECLASGVPPPDVSWFKGHQPV-SSWMGVTVSVDGRVLR 751
Query: 86 VKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWA 145
++Q + DAG Y C A+N GS + Y L V
Sbjct: 752 IEQAQLSDAGSYRCVASNVAGSTELRYGLRVN---------------------------V 784
Query: 146 RPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKW- 204
PR T P + V+ V + VRL C A+G P P + W+KD ++ A P + +
Sbjct: 785 PPRITLPPSLPGPVL---VNTPVRLTCNATGAPSPTLMWLKDGNPVS--PAGTPGLQVFP 839
Query: 205 ---TLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFG 261
L+L + R DSG+Y+C + G + DV+ + P + G +N +V
Sbjct: 840 GGRVLTLASARASDSGRYSCVAVSAVG----EDRQDVVLQVHMPPSILG-EELNVSVVAN 894
Query: 262 GTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLN 321
+ + +C+ + PV+ W K +GR + P V D + L
Sbjct: 895 ESVALECQSHAMPPPVLSWWK------DGR------------PLEPRPGVHLSADKALLQ 936
Query: 322 KLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPP-----------GPPVASSS 370
+ RA DAG Y C N G S + L V P P G P + S
Sbjct: 937 ---VDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSC 993
Query: 371 SATSLPWPVV 380
+P+P +
Sbjct: 994 ECRGVPFPKI 1003
Score = 84.7 bits (208), Expect = 2e-16
Identities = 84/355 (23%), Positives = 132/355 (37%), Gaps = 67/355 (18%)
Query: 7 LLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKD 66
L +L+PP L+G P + A L + L C G PPP W +
Sbjct: 1153 LSVLVPPELIGDLDP--------------LTNITAALHSPLTLLCEAMGIPPPAIRWFRG 1198
Query: 67 GRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGK 124
+ G + +L G LK+ Q + +D+G+Y C A+N G N+++ VL S
Sbjct: 1199 EEPVSPGEDTY-LLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIEN 1257
Query: 125 ESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITW 184
E L VI G + L C +GHP+P +TW
Sbjct: 1258 EDL-----------------------------EEVIKVLDGQTAHLMCNVTGHPQPKLTW 1288
Query: 185 MKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRS 244
KD + L R +A L + +G Y+C +N G +++ V+
Sbjct: 1289 FKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTI 1348
Query: 245 KPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFV 304
+ TV S C+ + P I W+K GA + I
Sbjct: 1349 LGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKD---GAPFEASRNIQ------- 1398
Query: 305 VLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP 359
+LP + L I A+++DAG Y C+ N +G + ++ + VL P
Sbjct: 1399 LLPG-----------THGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPP 1442
Score = 83.6 bits (205), Expect = 4e-16
Identities = 84/359 (23%), Positives = 133/359 (37%), Gaps = 69/359 (19%)
Query: 49 LQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCKATNGFG 106
L C PPP W ++ + + +G VL G L++ V E+AG Y CKA+N G
Sbjct: 1579 LYCDTNAIPPPDLTWYREDQPLSAG-DEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVG 1637
Query: 107 SLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGS 166
++Y L+VL P G E+ + + S
Sbjct: 1638 EDWLHYELLVLT----------PPVILGDTEELVEE-----------------VTVNASS 1670
Query: 167 SVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNR 226
+V L+C A G+P P I+W+++ + + + L + D+ Y C N+
Sbjct: 1671 TVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQ 1730
Query: 227 AGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEY 286
AG+ + + R + P + G T + S C V + P + W K
Sbjct: 1731 AGSAEKLFTL----RVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYK---- 1782
Query: 287 GAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGY 346
+ + +G + F++ T + L + RAR D+GMY C N G
Sbjct: 1783 -----DSQALSLGEEVFLLPGT------------HTLQLGRARLSDSGMYTCEALNAAGR 1825
Query: 347 SFRSAFLTVLPDP----KPPGPPVA----------SSSSATSLPWPVVIGIPAGAVFIL 391
+ L+VL P P GP A S +LP P V G +L
Sbjct: 1826 DQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVL 1884
Score = 82.0 bits (201), Expect = 1e-15
Identities = 102/410 (24%), Positives = 149/410 (36%), Gaps = 85/410 (20%)
Query: 20 PPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWS-RFR 78
P A R PP VV VA L +C G PPP W +DG+ + + + +
Sbjct: 1065 PQIAGPREPPTQVS-VVQDGVATL------ECNATGKPPPTVTWERDGQPVGAELGLQLQ 1117
Query: 79 VLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQED 138
Q L V++ + G Y C A N G + L VL + P+ G D
Sbjct: 1118 NQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVL---------VPPELI--GDLD 1166
Query: 139 PASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAE 198
P + I + S + L C A G P P I W + ++ ++ E
Sbjct: 1167 PLTN-----------------ITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTY 1209
Query: 199 PRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTV 258
W L + + +DSG Y+C SN AG + V+V+ + V +
Sbjct: 1210 LLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIEN--EDLEEVIKVL 1267
Query: 259 DFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWS-RPDG 317
D G T C V +P + W K +GR L GD PDG
Sbjct: 1268 D-GQTAHLMCNVTGHPQPKLTWFK------DGR-------------PLARGDAHHISPDG 1307
Query: 318 SYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPG-------------- 363
L + +A AG Y C+ AN +G + L+VL P G
Sbjct: 1308 VLLQ---VLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTV 1364
Query: 364 -PPVASSSSATSLPWPVVIGIPAGAVF--------ILGTLLLWLCQAQKK 404
P++ A + P P + + GA F + GT L + AQK+
Sbjct: 1365 NNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKE 1414
Score = 79.3 bits (194), Expect = 7e-15
Identities = 74/282 (26%), Positives = 106/282 (37%), Gaps = 58/282 (20%)
Query: 80 LPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDP 139
LP L++++V+ D G+Y C ATN G L VL
Sbjct: 655 LPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLV--------------------- 693
Query: 140 ASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEP 199
P +P + + V+ +SV L+C+ASG P PD++W K Q ++
Sbjct: 694 -------PPNIEPGPVNKAVLEN---ASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTV 743
Query: 200 RKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATY--KVDVIQRTRSKPVLTGTHPVNTT 257
L ++ + D+G Y C SN AG+ Y +V+V R P L G VNT
Sbjct: 744 SVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTP 803
Query: 258 VDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDG 317
V C P + WLK +G N G V P G V
Sbjct: 804 V------RLTCNATGAPSPTLMWLK------DG--NPVSPAGTPGLQVFPGGRV------ 843
Query: 318 SYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP 359
L + AR D+G Y C+ + +G + L V P
Sbjct: 844 -----LTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPP 880
Score = 79.0 bits (193), Expect = 1e-14
Identities = 81/329 (24%), Positives = 124/329 (37%), Gaps = 71/329 (21%)
Query: 40 VARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG----LKVKQVEREDAG 95
V+R G V + CPV G PP W KDG + R L G L++ +V+ DAG
Sbjct: 2133 VSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQ---RTLLHGSGHTLRISKVQLADAG 2189
Query: 96 VYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKM 155
++ C A + G N+TL V P +P +
Sbjct: 2190 IFTCVAASPAGVADRNFTLQV----------------------------QVPPVLEPVEF 2221
Query: 156 RRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPED 215
+ V+ GS V L C A G P P ++WMKD + P ++ ++ +L L+ + D
Sbjct: 2222 QNDVVVVR-GSLVELPCEARGVPLPLVSWMKDGE----PLLSQSLEQGPSLQLEAVGAGD 2276
Query: 216 SGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVK 275
SG Y+C + AG +++ V++ + P ++ G C + +
Sbjct: 2277 SGTYSCVAVSEAGEARRHFQLTVMEPPH---IEDSGQPTELSLTPGAPMELLCDAQGTPQ 2333
Query: 276 PVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGM 335
P I W K GQ L +R + R R DAG+
Sbjct: 2334 PNITWHK----------------DGQALTRLENNSRATR----------VLRVR--DAGL 2365
Query: 336 YICLGANTMGYSFRSAFLTVLPDPKPPGP 364
Y CL + G +S + V P GP
Sbjct: 2366 YTCLAESPAGAIEKSFRVRVQAPPNIVGP 2394
Score = 77.0 bits (188), Expect = 4e-14
Identities = 82/351 (23%), Positives = 125/351 (35%), Gaps = 73/351 (20%)
Query: 44 GRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWS---RFRVLPQGLKVKQVEREDAGVYVCK 100
G+ VRL C +G PPP W KDG + RF + L +K + DAG Y C
Sbjct: 2041 GQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCV 2100
Query: 101 ATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVI 160
A N G + +T+ VL P G D S ++
Sbjct: 2101 AHNPAGEDARLHTVNVL---VPPTIKQGADGSG------------------------TLV 2133
Query: 161 ARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYT 220
+RP G V + C G P ++W+KD L + TL + ++ D+G +T
Sbjct: 2134 SRP-GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFT 2192
Query: 221 CRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDF-GGTTSFQCKVRSDVKPVIQ 279
C ++ AG + + + V + PVL N V G C+ R P++
Sbjct: 2193 CVAASPAGVADRNFTLQV----QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVS 2248
Query: 280 WLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICL 339
W+K E + +++ G L + D+G Y C+
Sbjct: 2249 WMK----DGEPLLSQSLEQG---------------------PSLQLEAVGAGDSGTYSCV 2283
Query: 340 GANTMGYSFRSAFLTVLPDPK------------PPGPPVASSSSATSLPWP 378
+ G + R LTV+ P PG P+ A P P
Sbjct: 2284 AVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQP 2334
Score = 75.9 bits (185), Expect = 8e-14
Identities = 74/323 (22%), Positives = 124/323 (38%), Gaps = 58/323 (17%)
Query: 42 RLGRTVRLQCPVEGDPPPLTMWTKDGRTIH---SGWSRFRVLPQGLKVKQVEREDAGVYV 98
R G L C G P P W KDG+ + +G + + L + Q + G Y
Sbjct: 984 REGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYT 1043
Query: 99 CKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRR 158
C+ +N G+ S + L E P +G +E P TQ S ++
Sbjct: 1044 CECSNVVGNSSQDLQL----------EVHVPPQIAGPREPP----------TQVSVVQDG 1083
Query: 159 VIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGK 218
V L+C A+G P P +TW +D Q + + + + +L ++ + +G+
Sbjct: 1084 VAT--------LECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGR 1135
Query: 219 YTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHP--VNTTVDFGGTTSFQCKVRSDVKP 276
Y+C N AG +++ V+ P L G N T + C+ P
Sbjct: 1136 YSCVAENLAGRAERKFELSVL----VPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPP 1191
Query: 277 VIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMY 336
I+W + E + G + G W L +T+ ++ D+G+Y
Sbjct: 1192 AIRWFRGEEPVSPGEDTYLLAGG------------W---------MLKMTQTQEQDSGLY 1230
Query: 337 ICLGANTMGYSFRSAFLTVLPDP 359
CL +N G + R+ + VL P
Sbjct: 1231 SCLASNEAGEARRNFSVEVLVPP 1253
Score = 74.7 bits (182), Expect = 2e-13
Identities = 98/410 (23%), Positives = 147/410 (35%), Gaps = 69/410 (16%)
Query: 43 LGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCK 100
+G+ + L C G P P W ++GR + +V QG L + VE + +G++ C+
Sbjct: 512 VGQPLELPCQASGSPVPTIQWLQNGRPAEE-LAGVQVASQGTTLHIDHVELDHSGLFACQ 570
Query: 101 ATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVI 160
ATN G+ + V + +PG + G E +S P P +
Sbjct: 571 ATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSF----PAACDPP------V 620
Query: 161 ARPVGSSVRLKCVASGHPRPDIT--WMKDDQALTRPEAAEPRKK-KWTLSLKNLRPEDSG 217
R G+ HP+P + W P L ++ + D G
Sbjct: 621 HRGWGA----------HPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEG 670
Query: 218 KYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPV 277
YTC +N AG + V+ +P PVN V + + +C P
Sbjct: 671 IYTCAATNLAGESKREVALKVLVPPNIEP-----GPVNKAVLENASVTLECLASGVPPPD 725
Query: 278 IQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYI 337
+ W K + T+ V G+ L I +A+ DAG Y
Sbjct: 726 VSWFKGHQ-PVSSWMGVTVSVDGRV--------------------LRIEQAQLSDAGSYR 764
Query: 338 CLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIP----AGAVFILGT 393
C+ +N G + L V P+ PP SLP PV++ P A
Sbjct: 765 CVASNVAGSTELRYGLRVNVPPRITLPP--------SLPGPVLVNTPVRLTCNATGAPSP 816
Query: 394 LLLWLCQAQKKPCTPAPAPPL---PGHRPPGTARDRSGDKDLPSLAALSA 440
L+WL P +PA P L PG R A R+ D S A+SA
Sbjct: 817 TLMWL--KDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSA 864
Score = 74.3 bits (181), Expect = 2e-13
Identities = 78/302 (25%), Positives = 110/302 (36%), Gaps = 57/302 (18%)
Query: 47 VRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG---LKVKQVEREDAGVYVCKATN 103
V+L C G P P W KDG + + S V +G L++ + + DAGVY CKA+N
Sbjct: 329 VQLLCEARGVPTPNITWFKDGALLPT--STKVVYTRGGRQLQLGRAQSSDAGVYTCKASN 386
Query: 104 GFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARP 163
G+ L V + P E G R V+
Sbjct: 387 AVGAAEKATRLDVY--VPPTIEGAGG--------------------------RPYVVKAV 418
Query: 164 VGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRV 223
G V L+CVA GHP P ++W + + + L L++ SG Y+C
Sbjct: 419 AGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVA 478
Query: 224 SNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKR 283
S+ AG Y V+V Q V G V T V G C+ P IQWL+
Sbjct: 479 SSPAGEAVLQYSVEV-QVPPQLLVAEGLGQVTTIV--GQPLELPCQASGSPVPTIQWLQN 535
Query: 284 VEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANT 343
G + + V Q G+ L+ I D +G++ C N
Sbjct: 536 ---GRPAEELAGVQVASQ---------------GTTLH---IDHVELDHSGLFACQATNE 574
Query: 344 MG 345
G
Sbjct: 575 AG 576
Score = 73.2 bits (178), Expect = 5e-13
Identities = 93/392 (23%), Positives = 134/392 (34%), Gaps = 78/392 (19%)
Query: 20 PPAAAARGPPKMADKVVPRQVARL-GRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFR 78
P A + PP + ++V L G V LQC G P P WTKD + + G +
Sbjct: 207 PHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQ 266
Query: 79 VLPQG--LKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQ 136
V G L++ D G Y C A + G + ++ L V P + G
Sbjct: 267 VQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRV----------HAPPTIWGSN 316
Query: 137 EDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEA 196
E +A V+L C A G P P+ITW KD L
Sbjct: 317 ETGE-------------------VAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTK 357
Query: 197 AEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGT--HPV 254
+ L L + D+G YTC+ SN GA ++DV P + G P
Sbjct: 358 VVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY----VPPTIEGAGGRPY 413
Query: 255 NTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSR 314
G + +C R P + W H+ + V L T
Sbjct: 414 VVKAVAGRPVALECVARGHPSPTLSW-----------HHEGLPVAESNESRLET------ 456
Query: 315 PDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATS 374
DGS L + + +G+Y C+ ++ P G V S
Sbjct: 457 -DGSVLR---LESPGEASSGLYSCVASS------------------PAGEAVLQYSVEVQ 494
Query: 375 LPWPVVIGIPAGAV-FILGTLLLWLCQAQKKP 405
+P +++ G V I+G L CQA P
Sbjct: 495 VPPQLLVAEGLGQVTTIVGQPLELPCQASGSP 526
Score = 73.2 bits (178), Expect = 5e-13
Identities = 91/402 (22%), Positives = 144/402 (35%), Gaps = 90/402 (22%)
Query: 7 LLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKD 66
L +LL P +LG G AD+ V + + L C P P W KD
Sbjct: 1340 LSVLLAPTILG---------GAEDSADEEV---TVTVNNPISLICEALAFPSPNITWMKD 1387
Query: 67 GRTIHSGWSRFRVLP--QGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGK 124
G + ++LP GL++ ++EDAG Y C TN G NY + VL I P
Sbjct: 1388 GAPFEAS-RNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVL--IPP-- 1442
Query: 125 ESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITW 184
S ++DP + + + V S++ L+C + P P I W
Sbjct: 1443 --------SISKDDPLGEVGVKE------------VKTKVNSTLTLECESWAVPPPTIRW 1482
Query: 185 MKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRS 244
KD Q +T + + L ++ + DSG+Y C +N AG + + V + +
Sbjct: 1483 YKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI----QV 1538
Query: 245 KPVLTGTHPVNTTVDF--------GGTTSFQ-----------CKVRSDVKPVIQWLKRVE 285
P+ + + GG T ++ C + P + W + +
Sbjct: 1539 PPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQ 1598
Query: 286 YGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMG 345
+ G S + G L I R ++AG Y C +N +G
Sbjct: 1599 PLSAGDEVSVLQGG---------------------RVLQIPLVRAENAGRYSCKASNEVG 1637
Query: 346 YSFRSAFLTVLPDPKPPGPP-------VASSSSATSLPWPVV 380
+ L VL P G ++SS SL P +
Sbjct: 1638 EDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPAL 1679
Score = 69.3 bits (168), Expect = 8e-12
Identities = 82/321 (25%), Positives = 112/321 (34%), Gaps = 57/321 (17%)
Query: 47 VRLQCPVEGDPPPLTMWTKDGRTIH-SGWSRFRVLPQG--LKVKQVEREDAGVYVCKATN 103
VRL C G P P MW KDG + +G +V P G L + D+G Y C A +
Sbjct: 804 VRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVS 863
Query: 104 GFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARP 163
G + L V P S G ++ V+A
Sbjct: 864 AVGEDRQDVVLQVHM----------PPSILG------------------EELNVSVVAN- 894
Query: 164 VGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRV 223
SV L+C + P P ++W KD + L K L + D+G YTC
Sbjct: 895 --ESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEA 952
Query: 224 SNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKR 283
N+AG Y ++V PV TV G TS C+ R P I W K
Sbjct: 953 LNQAGRSEKHYNLNV----WVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRK- 1007
Query: 284 VEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANT 343
GQ LP + + L + +A+ G Y C +N
Sbjct: 1008 ---------------DGQP---LPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNV 1049
Query: 344 MGYSFRSAFLTVLPDPKPPGP 364
+G S + L V P+ GP
Sbjct: 1050 VGNSSQDLQLEVHVPPQIAGP 1070
Score = 54.3 bits (129), Expect = 3e-07
Identities = 75/341 (21%), Positives = 127/341 (37%), Gaps = 65/341 (19%)
Query: 44 GRTVRLQCPVEGDPPPLTMWTKDGRTIHS--GWSRF------------RVLPQGLKVKQV 89
G+++ L+C G P P +W KD + + GW+ + R+L +G +
Sbjct: 111 GQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSL-HF 169
Query: 90 EREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRF 149
R G + GS +P L +G ++ P ++ P
Sbjct: 170 PRIQPGRSGRRGAQAGGSAQTK---------APWXAGL-----AGFEQFPTPHAFSPP-- 213
Query: 150 TQPSKM---RRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQ-ALTRPEAAEPRKKKWT 205
PS + + + G+ V L+C SG P P + W KD Q L + ++
Sbjct: 214 APPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQV 273
Query: 206 LSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPV-NTTVDFGGTT 264
L + D G+Y C + AG +++ R + P + G++ V
Sbjct: 274 LRITGSHVGDEGRYQCVAFSPAGQQARDFQL----RVHAPPTIWGSNETGEVAVMEDHLV 329
Query: 265 SFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGD--VWSRPDGSYLNK 322
C+ R P I W K +G +LPT V++R +
Sbjct: 330 QLLCEARGVPTPNITWFK------DG-------------ALLPTSTKVVYTRGG----RQ 366
Query: 323 LLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPG 363
L + RA+ DAG+Y C +N +G + ++ L V P G
Sbjct: 367 LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEG 407
Score = 49.7 bits (117), Expect = 6e-06
Identities = 43/147 (29%), Positives = 58/147 (39%), Gaps = 33/147 (22%)
Query: 51 CPVEGDPPPLTMWTK--DGRTIHSGWSRFRVLPQG-LKVKQVEREDAGVYVCKATNGFGS 107
C G P P W K +H G VL +G L + V D+G Y C+ATN GS
Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLH-GQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGS 82
Query: 108 LSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSS 167
S LVV + P G R+ ++ G S
Sbjct: 83 TSRRAKLVVY--VPPSIREDG---------------------------RKANVSGMAGQS 113
Query: 168 VRLKCVASGHPRPDITWMKDDQALTRP 194
+ L+C A+G P P+I W+KD Q + P
Sbjct: 114 LTLECDANGFPVPEIVWLKDAQLVGVP 140
Score = 42.4 bits (98), Expect = 0.001
Identities = 29/114 (25%), Positives = 48/114 (42%), Gaps = 8/114 (7%)
Query: 172 CVASGHPRPDITWMKDDQALTRPEAAEPRK---KKWTLSLKNLRPEDSGKYTCRVSNRAG 228
C G P+P +TW K + P +P ++ +L L ++ P DSG Y C+ +N G
Sbjct: 24 CGTHGTPKPQVTWRKGPSS--EPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVG 81
Query: 229 AINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLK 282
+ + K+ V + N + G + + +C P I WLK
Sbjct: 82 STSRRAKLVVYV---PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLK 132
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 107 bits (267), Expect = 3e-23
Identities = 105/375 (28%), Positives = 137/375 (36%), Gaps = 82/375 (21%)
Query: 29 PKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKVK 87
P + + +P G L C G P P W KDG+ + +F + P G L VK
Sbjct: 4037 PPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVK 4096
Query: 88 QVEREDAGVYVCKATNGFGSL--SVNYTLVVLDDIS--PGKESLGPDSSSGGQEDPASQQ 143
+E +DAG Y C A N G V+ T++VL + PG SL
Sbjct: 4097 NLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSL---------------- 4140
Query: 144 WARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKK 203
+G + L+C A G P P I W +D+ +T E +
Sbjct: 4141 -------------------RLGDRLWLRCAARGSPTPRIGWTVNDRPVT--EGVSEQDGG 4179
Query: 204 WTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGT 263
TL + EDSG Y C NR G A V V + PVL G GG+
Sbjct: 4180 STLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHV----KEAPVLQGEAFSYLVEPVGGS 4235
Query: 264 TSFQCKVRSDVKPVIQWLK--RVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLN 321
C VR D P I W+K G+ RH L G
Sbjct: 4236 IQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQ------------LQNG------------ 4271
Query: 322 KLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP----KP------PGPPVASSSS 371
L I R +DDAG Y CL N MG + + L + P +P G VA
Sbjct: 4272 SLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQ 4331
Query: 372 ATSLPWPVVIGIPAG 386
AT P P + + AG
Sbjct: 4332 ATGEPTPTIEWLQAG 4346
Score = 102 bits (255), Expect = 6e-22
Identities = 102/387 (26%), Positives = 142/387 (36%), Gaps = 71/387 (18%)
Query: 7 LLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKD 66
LL+L PP++LG +++V TV LQCP G+P P W ++
Sbjct: 2836 LLVLTPPVILGD-------------TEELVEEVTVNASSTVSLQCPALGNPVPTISWLQN 2882
Query: 67 GRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGK 124
G S R +VL G L+V E DA Y+C A N GS +TL V + P
Sbjct: 2883 GLPF-SPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRV--QVPPRI 2939
Query: 125 ESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITW 184
L + + + SSV L C HP P++TW
Sbjct: 2940 AGLDLEQ----------------------------VTAILNSSVSLPCDVHAHPNPEVTW 2971
Query: 185 MKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRS 244
KD QAL+ E TL L R DSG YTC N AG ++ V+
Sbjct: 2972 YKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAF 3031
Query: 245 KPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFV 304
+ G V G C+ + +P + W K + + + GGQ
Sbjct: 3032 RQAPRGPQDA-VLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALR-GGQ--- 3086
Query: 305 VLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGP 364
+L I A+ D G+Y C +N G + R+ LTV P P
Sbjct: 3087 -----------------RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENP 3129
Query: 365 PVASSSSATSLPWPV---VIGIPAGAV 388
+ S P + V G+PA V
Sbjct: 3130 KTETVSQVAGSPLVLTCDVSGVPAPTV 3156
Score = 98.6 bits (244), Expect = 1e-20
Identities = 88/320 (27%), Positives = 128/320 (40%), Gaps = 61/320 (19%)
Query: 42 RLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKA 101
RLG + L+C G P P WT + R + G S + L+ V RED+G YVC A
Sbjct: 4141 RLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSE-QDGGSTLQRAAVSREDSGTYVCWA 4199
Query: 102 TNGFG-SLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVI 160
N G + +V++ V +E P Q A +
Sbjct: 4200 ENRVGRTQAVSFVHV--------------------KEAPVLQGEAFS-----------YL 4228
Query: 161 ARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYT 220
PVG S++L CV G P PDI W+KD L R + + +L++ +D+G+Y
Sbjct: 4229 VEPVGGSIQLDCVVRGDPVPDIHWIKDGLPL-RGSHLRHQLQNGSLTIHRTERDDAGRYQ 4287
Query: 221 CRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQW 280
C N G K VI +S PV P + TV G + +C+ + P I+W
Sbjct: 4288 CLAENEMGVA----KKVVILVLQSAPVFQ-VEPQDMTVRSGDDVALRCQATGEPTPTIEW 4342
Query: 281 LKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLG 340
L+ + R T LP G +W + DAG Y C+
Sbjct: 4343 LQAGQPLRASRRLRT----------LPDGSLW------------LENVETGDAGTYDCVA 4380
Query: 341 ANTMGYSFRSAFLTVLPDPK 360
N +G + AFL V +P+
Sbjct: 4381 HNLLGSATARAFLVVRGEPQ 4400
Score = 97.1 bits (240), Expect = 3e-20
Identities = 93/369 (25%), Positives = 160/369 (43%), Gaps = 48/369 (13%)
Query: 20 PPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRV 79
PP+ + P + + V ++ T+ L+C PPP W KDG+ + SR +V
Sbjct: 2632 PPSISKDDP--LGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPS-SRLQV 2688
Query: 80 LPQG--LKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQE 137
L +G L+++ + D+G Y+C ATN G ++ +++ + P + +G S++ E
Sbjct: 2689 LGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI--QVPPMFQKVGDFSAAF--E 2744
Query: 138 DPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAA 197
+ ++ AR T+ R ++ + L C + P PD+TW ++DQ L+ +
Sbjct: 2745 ILSREEEARGGVTE----YREIVEN---NPAYLYCDTNAIPPPDLTWYREDQPLSAGDEV 2797
Query: 198 EPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHP---V 254
+ L + +R E++G+Y+C+ SN G Y++ V+ + PV+ G
Sbjct: 2798 SVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVL----TPPVILGDTEELVE 2853
Query: 255 NTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSR 314
TV+ T S QC + P I WL+ N + VL G V
Sbjct: 2854 EVTVNASSTVSLQCPALGNPVPTISWLQ----------NGLPFSPSPRLQVLEDGQV--- 2900
Query: 315 PDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPG----PPVASSS 370
L ++ A DA Y+C+ N G + + L V P+ G A +
Sbjct: 2901 --------LQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILN 2952
Query: 371 SATSLPWPV 379
S+ SLP V
Sbjct: 2953 SSVSLPCDV 2961
Score = 96.3 bits (238), Expect = 6e-20
Identities = 89/325 (27%), Positives = 132/325 (40%), Gaps = 57/325 (17%)
Query: 28 PPKMADKVVPRQVARL-GRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--L 84
PP + ++ + + L G+T L C V G P P W KDGR + G + P G L
Sbjct: 2443 PPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARG-DAHHISPDGVLL 2501
Query: 85 KVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQW 144
+V Q AG Y C A N G + ++ L VL L P + GG ED A ++
Sbjct: 2502 QVLQANLSSAGHYSCIAANAVGEKTKHFQLSVL---------LAP-TILGGAEDSADEE- 2550
Query: 145 ARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKW 204
+ V + + L C A P P+ITWMKD +
Sbjct: 2551 ---------------VTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTH 2595
Query: 205 TLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVI---QRTRSKPV-LTGTHPVNTTVDF 260
L + N + ED+G+YTC V+N G Y V+V+ ++ P+ G V T V+
Sbjct: 2596 GLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVN- 2654
Query: 261 GGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYL 320
T + +C+ + P I+W K GQ V P+ + +G L
Sbjct: 2655 -STLTLECESWAVPPPTIRWYK----------------DGQP--VTPSSRLQVLGEGRLL 2695
Query: 321 NKLLITRARQDDAGMYICLGANTMG 345
I + D+G Y+C+ N G
Sbjct: 2696 Q---IQPTQVSDSGRYLCVATNVAG 2717
Score = 94.7 bits (234), Expect = 2e-19
Identities = 87/314 (27%), Positives = 122/314 (38%), Gaps = 61/314 (19%)
Query: 47 VRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKVKQVEREDAGVYVCKATNGF 105
V L C G P P W K+G + +G S +VLP G L++ EDAG Y+C A N
Sbjct: 3965 VLLPCEASGIPRPTITWQKEGLNVATGVST-QVLPGGQLRIAHASPEDAGNYLCIAKNSA 4023
Query: 106 GSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVG 165
GS LVV + P E+ PD S+ G
Sbjct: 4024 GSAMGKTRLVV--QVPPVIENGLPDLST-----------------------------TEG 4052
Query: 166 SSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSN 225
S L C A G P P+ITW KD Q ++ E + L +KNL +D+G YTC N
Sbjct: 4053 SHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAEN 4112
Query: 226 RAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVE 285
G + ++ PV T T P + ++ G +C R P I W
Sbjct: 4113 AVGRARRRVHLTIL----VLPVFT-TLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDR 4167
Query: 286 YGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMG 345
EG V + GS L + ++R +D+G Y+C N +G
Sbjct: 4168 PVTEG--------------------VSEQDGGSTLQRAAVSR---EDSGTYVCWAENRVG 4204
Query: 346 YSFRSAFLTVLPDP 359
+ +F+ V P
Sbjct: 4205 RTQAVSFVHVKEAP 4218
Score = 91.3 bits (225), Expect = 2e-18
Identities = 93/335 (27%), Positives = 127/335 (37%), Gaps = 64/335 (19%)
Query: 28 PPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKV 86
PP +AD V + V L C G P P W+K G + + S +RV P G L++
Sbjct: 3856 PPTIADDQTDFTVTMMAPVV-LTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEI 3914
Query: 87 KQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWAR 146
Q AG Y C A N G + L V Q P
Sbjct: 3915 GQALPIHAGRYTCSARNSAGVAHKHVFLTV-------------------QASPV------ 3949
Query: 147 PRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTL 206
+P R +A V L C ASG PRP ITW K+ + + + L
Sbjct: 3950 ---VKPLPSVVRAVAE---EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQV-LPGGQL 4002
Query: 207 SLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSF 266
+ + PED+G Y C N AG+ ++ V + PV+ P +T + G
Sbjct: 4003 RIAHASPEDAGNYLCIAKNSAGSAMGKTRLVV----QVPPVIENGLPDLSTTE-GSHAFL 4057
Query: 267 QCKVRSDVKPVIQWLK--RVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLL 324
CK R +P I W K + GAEG KF + P+G+ LL
Sbjct: 4058 PCKARGSPEPNITWDKDGQPVSGAEG-----------KFTIQPSGE------------LL 4094
Query: 325 ITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP 359
+ DAG Y C N +G + R LT+L P
Sbjct: 4095 VKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLP 4129
Score = 88.6 bits (218), Expect = 1e-17
Identities = 94/360 (26%), Positives = 138/360 (38%), Gaps = 63/360 (17%)
Query: 28 PPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKV 86
PP++ + G L C G P P WTK+ + S + V +G L +
Sbjct: 975 PPRI-HPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLI 1033
Query: 87 KQVEREDAGVYVCKATN--GFGS----LSVN-----------YTLVVLDDISPGKESLGP 129
Q +DAG YVC ATN GF S LSVN Y L+ + + +G
Sbjct: 1034 AQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGD 1093
Query: 130 ----DSSSGGQEDPASQQWAR----PRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPD 181
+ ++ AS ++ P QP RV+ VG ++ L CVA G+P P
Sbjct: 1094 SGHYECTASNPAGSASHRYVLGVQVPPQVQPGP---RVLKVLVGEALDLNCVAEGNPEPQ 1150
Query: 182 ITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQR 241
++W KD L + R + ++ +R D+G+Y C SN AG ++ V++
Sbjct: 1151 LSWSKDGVVL------QGRGPQGSVHFAAIRTSDAGRYRCEASNSAGVDAWEVELRVLE- 1203
Query: 242 TRSKPVLTGTHPVNTTVD--FGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVG 299
P G + ++ G S C R KP + W K +E H G
Sbjct: 1204 ----PPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGP--SSEPLH------G 1251
Query: 300 GQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP 359
VL G L + D+G Y C N +G + R A L V P
Sbjct: 1252 QPGVAVLEEG------------SLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPP 1299
Score = 88.6 bits (218), Expect = 1e-17
Identities = 80/336 (23%), Positives = 125/336 (37%), Gaps = 57/336 (16%)
Query: 28 PPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLP--QGLK 85
PP++A + + A L +V L C V P P W KD + + G F +LP L+
Sbjct: 2936 PPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVF-LLPGTHTLQ 2994
Query: 86 VKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWA 145
+ + D+G+Y C+A N G + LV L + P
Sbjct: 2995 LGRARLSDSGMYTCEALNAAGR---DQKLVQLSVLVP----------------------- 3028
Query: 146 RPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWT 205
P F Q + + + VG L C P P +TW KD Q L + + +
Sbjct: 3029 -PAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQR 3087
Query: 206 LSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTS 265
L ++ + D G Y+C+VSN AG T+ + V + P + G
Sbjct: 3088 LEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTV----QVPPTFENPKTETVSQVAGSPLV 3143
Query: 266 FQCKVRSDVKPVIQWLK-RVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLL 324
C V P + WLK R+ + H + GG +L
Sbjct: 3144 LTCDVSGVPAPTVTWLKDRMPVESSAVH-GVVSRGG---------------------RLQ 3181
Query: 325 ITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPK 360
++R + AG Y C+ NT + + + VL P+
Sbjct: 3182 LSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPR 3217
Score = 88.6 bits (218), Expect = 1e-17
Identities = 86/320 (26%), Positives = 119/320 (37%), Gaps = 60/320 (18%)
Query: 43 LGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKVKQVEREDAGVYVCKA 101
+ +T L C +G P PL W KD + RF +LP+G L+++ V +DAG Y+C A
Sbjct: 3686 VNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLA 3745
Query: 102 TNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIA 161
+N GS L VL+ P PS + A
Sbjct: 3746 SNSAGSDRQGRDLRVLE----------------------------PPAIAPSPSNLTLTA 3777
Query: 162 RPVGSSVRLKCVASGHPRPDITWMKDDQAL--TRPEAAEPRKKKWTLSLKNLRPEDSGKY 219
+ L C ASG P+P + W KD Q L + A L L P+DS ++
Sbjct: 3778 H---TPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQF 3834
Query: 220 TCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQ 279
C VSN G + Y+V V P + TV C P +
Sbjct: 3835 ECVVSNEVGEAHRLYQVTV-----HVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVS 3889
Query: 280 WLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICL 339
W K GA+ + G + V P+G L I +A AG Y C
Sbjct: 3890 WSKA---GAQ------LGARGSGYRVSPSG------------ALEIGQALPIHAGRYTCS 3928
Query: 340 GANTMGYSFRSAFLTVLPDP 359
N+ G + + FLTV P
Sbjct: 3929 ARNSAGVAHKHVFLTVQASP 3948
Score = 87.4 bits (215), Expect = 3e-17
Identities = 92/378 (24%), Positives = 147/378 (38%), Gaps = 69/378 (18%)
Query: 28 PPKMADKVVPRQVARL-GRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGLKV 86
PP + D P +++ G + L C +G P P W KDG+ + +R + +V
Sbjct: 3493 PPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL----TRLENNSRATRV 3548
Query: 87 KQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWAR 146
+V DAG+Y C A + G++ ++ + V Q P
Sbjct: 3549 LRVR--DAGLYTCLAESPAGAIEKSFRVRV-------------------QAPPNIVGPRG 3587
Query: 147 PRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTL 206
PRF V+ G V L+C P P ITW +D L + ++ L
Sbjct: 3588 PRF---------VVGLAPGQLV-LECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFL 3637
Query: 207 SLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVL-TGTHPVNTTVDFGGTTS 265
L+ L DSG Y+C N AG+ + ++V++ + P + +G VN +V+ T
Sbjct: 3638 QLQALSTADSGDYSCTARNAAGSTSVAFRVEI----HTVPTIRSGPPAVNVSVN--QTAL 3691
Query: 266 FQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLI 325
C+ P++ W K +D +F +LP G + +P
Sbjct: 3692 LPCQADGVPAPLVSWRK---------DRVPLDPRSPRFEILPEGSLRIQP---------- 3732
Query: 326 TRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIPA 385
DAG Y+CL +N+ G + L VL P +A S S +L +P
Sbjct: 3733 --VLAQDAGHYLCLASNSAGSDRQGRDLRVLEP-----PAIAPSPSNLTLTAHTPALLPC 3785
Query: 386 GAVFILGTLLLWLCQAQK 403
A L++W QK
Sbjct: 3786 EASGSPKPLVVWWKDGQK 3803
Score = 87.0 bits (214), Expect = 4e-17
Identities = 95/370 (25%), Positives = 144/370 (38%), Gaps = 77/370 (20%)
Query: 28 PPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--LK 85
PP + V + V +V L+C G PPP W K + + S W V G L+
Sbjct: 1885 PPNIEPGPVNKAVLE-NASVTLECLASGVPPPDVSWFKGHQPV-SSWMGVTVSVDGRVLR 1942
Query: 86 VKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWA 145
++Q + DAG Y C A+N GS + Y L V
Sbjct: 1943 IEQAQLSDAGSYRCVASNVAGSTELRYGLRVN---------------------------V 1975
Query: 146 RPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKW- 204
PR T P + V+ V + VRL C A+G P P + W+KD ++ A P + +
Sbjct: 1976 PPRITLPPSLPGPVL---VNTPVRLTCNATGAPSPTLMWLKDGNPVS--PAGTPGLQVFP 2030
Query: 205 ---TLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFG 261
L+L + R DSG+Y+C + G + DV+ + P + G +N +V
Sbjct: 2031 GGRVLTLASARASDSGRYSCVAVSAVG----EDRQDVVLQVHMPPSILG-EELNVSVVAN 2085
Query: 262 GTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLN 321
+ + +C+ + PV+ W K +GR + P V D + L
Sbjct: 2086 ESVALECQSHAMPPPVLSWWK------DGR------------PLEPRPGVHLSADKALLQ 2127
Query: 322 KLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPP-----------GPPVASSS 370
+ RA DAG Y C N G+S + L V P P G P + S
Sbjct: 2128 ---VDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSC 2184
Query: 371 SATSLPWPVV 380
+P+P +
Sbjct: 2185 ECRGVPFPKI 2194
Score = 84.7 bits (208), Expect = 2e-16
Identities = 84/355 (23%), Positives = 132/355 (37%), Gaps = 67/355 (18%)
Query: 7 LLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKD 66
L +L+PP L+G P + A L + L C G PPP W +
Sbjct: 2344 LSVLVPPELIGDLDP--------------LTNITAALHSPLTLLCEAMGIPPPAIRWFRG 2389
Query: 67 GRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGK 124
+ G + +L G LK+ Q + +D+G+Y C A+N G N+++ VL S
Sbjct: 2390 EEPVSPGEDTY-LLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIEN 2448
Query: 125 ESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITW 184
E L VI G + L C +GHP+P +TW
Sbjct: 2449 EDL-----------------------------EEVIKVLDGQTAHLMCNVTGHPQPKLTW 2479
Query: 185 MKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRS 244
KD + L R +A L + +G Y+C +N G +++ V+
Sbjct: 2480 FKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTI 2539
Query: 245 KPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFV 304
+ TV S C+ + P I W+K GA + I
Sbjct: 2540 LGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKD---GAPFEASRNIQ------- 2589
Query: 305 VLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP 359
+LP + L I A+++DAG Y C+ N +G + ++ + VL P
Sbjct: 2590 LLPG-----------THGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPP 2633
Score = 83.6 bits (205), Expect = 4e-16
Identities = 89/330 (26%), Positives = 123/330 (37%), Gaps = 67/330 (20%)
Query: 36 VPRQVA-RLGRTVRLQCPVEGDPPPLTMWTK-DGRTIH-----SGWSRFRVLPQG-LKVK 87
+PR V LGR+ L C G PPP W + DG+ + SR R G L +
Sbjct: 791 LPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFE 850
Query: 88 QVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARP 147
V ED YVC+A N FG + L+V P S P
Sbjct: 851 SVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTV---------------- 894
Query: 148 RFTQPSKMRRRVIARPVGSSVRLKC-VASGHPRPDITWMKDDQALTRPEAAEPRKKKWTL 206
RV+ G V L C V +G P P+ W+KD + L P + + +L
Sbjct: 895 ----------RVLE---GQPVSLPCIVLAGRPLPERHWLKDGRPLP-PGSRHSIRADGSL 940
Query: 207 SLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSF 266
L E +G+Y+C +N AG+ + ++ V R P T TH + G S
Sbjct: 941 HLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHP--TATHHITNE---GVPASL 995
Query: 267 QCKVRSDVKPVIQWLKRVE-YGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLI 325
C P I W K + G H + G LLI
Sbjct: 996 PCVASGVPAPTITWTKETNALTSRGPHYNVSKEG----------------------TLLI 1033
Query: 326 TRARQDDAGMYICLGANTMGYSFRSAFLTV 355
+ DAG Y+C NT+G+S + L+V
Sbjct: 1034 AQPSAQDAGAYVCTATNTVGFSSQEMRLSV 1063
Score = 83.6 bits (205), Expect = 4e-16
Identities = 84/359 (23%), Positives = 133/359 (37%), Gaps = 69/359 (19%)
Query: 49 LQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCKATNGFG 106
L C PPP W ++ + + +G VL G L++ V E+AG Y CKA+N G
Sbjct: 2770 LYCDTNAIPPPDLTWYREDQPLSAG-DEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVG 2828
Query: 107 SLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGS 166
++Y L+VL P G E+ + + S
Sbjct: 2829 EDWLHYELLVLT----------PPVILGDTEELVEE-----------------VTVNASS 2861
Query: 167 SVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNR 226
+V L+C A G+P P I+W+++ + + + L + D+ Y C N+
Sbjct: 2862 TVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQ 2921
Query: 227 AGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEY 286
AG+ + + R + P + G T + S C V + P + W K
Sbjct: 2922 AGSAEKLFTL----RVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYK---- 2973
Query: 287 GAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGY 346
+ + +G + F++ T + L + RAR D+GMY C N G
Sbjct: 2974 -----DSQALSLGEEVFLLPGT------------HTLQLGRARLSDSGMYTCEALNAAGR 3016
Query: 347 SFRSAFLTVLPDP----KPPGPPVA----------SSSSATSLPWPVVIGIPAGAVFIL 391
+ L+VL P P GP A S +LP P V G +L
Sbjct: 3017 DQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVL 3075
Score = 82.4 bits (202), Expect = 9e-16
Identities = 82/336 (24%), Positives = 127/336 (37%), Gaps = 64/336 (19%)
Query: 43 LGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKVKQVEREDAGVYVCKA 101
+G + L C EG+P P W+KDG + PQG + + DAG Y C+A
Sbjct: 1133 VGEALDLNCVAEGNPEPQLSWSKDGVVLQGRG------PQGSVHFAAIRTSDAGRYRCEA 1186
Query: 102 TNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIA 161
+N G + L VL+ G D +SG ++
Sbjct: 1187 SNSAGVDAWEVELRVLEP-----PHWGADETSG------------------------LLE 1217
Query: 162 RPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRK---KKWTLSLKNLRPEDSGK 218
R G + L C A G P+P +TW K + P +P ++ +L L ++ P DSG
Sbjct: 1218 RVAGENASLPCPARGTPKPQVTWRKGPSS--EPLHGQPGVAVLEEGSLFLASVSPADSGD 1275
Query: 219 YTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVI 278
Y C+ +N G+ + K+ V + N + G + + +C P I
Sbjct: 1276 YECQATNEVGSTSRRAKLVVYV---PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEI 1332
Query: 279 QWLKRVE-------YGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQD 331
WLK + + G VGG + + +G L+ R ++
Sbjct: 1333 VWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLL----------DEGQSLH---FPRIQEG 1379
Query: 332 DAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPVA 367
D+G+Y C N G + R L VL P G A
Sbjct: 1380 DSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAA 1415
Score = 82.0 bits (201), Expect = 1e-15
Identities = 101/417 (24%), Positives = 145/417 (34%), Gaps = 98/417 (23%)
Query: 28 PPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQ-GLKV 86
PP++ P G T L C V G+ P W +D R + + R L L++
Sbjct: 517 PPQLVP--APNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEI 574
Query: 87 KQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWAR 146
+ D G Y C A+N G + L+V + P S SQ
Sbjct: 575 SGIIPTDGGRYQCVASNANGVTRASVWLLVRE---------APQVSIHTSSQHFSQ---- 621
Query: 147 PRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTL 206
G V++ C ASG+P P I+W ++ QAL + TL
Sbjct: 622 ------------------GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV-DAQGTL 662
Query: 207 SLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSF 266
++ + PED+G Y+C+ +N G T V P ++ + V V G
Sbjct: 663 IIQGVAPEDAGNYSCQATNEVGTDQET----VTLYYTDPPSVSAVNAV-VLVAVGEEAVL 717
Query: 267 QCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLIT 326
C+ P + W + GG + ++ P +GS KL I
Sbjct: 718 VCEASGVPPPRVIWYR----------------GGLEMILAP--------EGSSSGKLRIP 753
Query: 327 RARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIPAG 386
A++ DAG Y C N +G + L V P+ T LP V +
Sbjct: 754 AAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQ-----------LTELPRDVTVE---- 798
Query: 387 AVFILGTLLLWLCQAQKKPCTPAPAPPLPGHRPPGTARDRSGDKDLPSLAALSAGPG 443
LG L C+A RPP T R GD P L AG G
Sbjct: 799 ----LGRSALLACRAT--------------GRPPPTVTWRRGDGQ-PLGLRLGAGRG 836
Score = 82.0 bits (201), Expect = 1e-15
Identities = 102/410 (24%), Positives = 149/410 (36%), Gaps = 85/410 (20%)
Query: 20 PPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWS-RFR 78
P A R PP VV VA L +C G PPP W +DG+ + + + +
Sbjct: 2256 PQIAGPREPPTQVS-VVQDGVATL------ECNATGKPPPTVTWERDGQPVGAELGLQLQ 2308
Query: 79 VLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQED 138
Q L V++ + G Y C A N G + L VL + P+ G D
Sbjct: 2309 NQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVL---------VPPELI--GDLD 2357
Query: 139 PASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAE 198
P + I + S + L C A G P P I W + ++ ++ E
Sbjct: 2358 PLTN-----------------ITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTY 2400
Query: 199 PRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTV 258
W L + + +DSG Y+C SN AG + V+V+ + V +
Sbjct: 2401 LLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIEN--EDLEEVIKVL 2458
Query: 259 DFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWS-RPDG 317
D G T C V +P + W K +GR L GD PDG
Sbjct: 2459 D-GQTAHLMCNVTGHPQPKLTWFK------DGR-------------PLARGDAHHISPDG 2498
Query: 318 SYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPG-------------- 363
L + +A AG Y C+ AN +G + L+VL P G
Sbjct: 2499 VLLQ---VLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTV 2555
Query: 364 -PPVASSSSATSLPWPVVIGIPAGAVF--------ILGTLLLWLCQAQKK 404
P++ A + P P + + GA F + GT L + AQK+
Sbjct: 2556 NNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKE 2605
Score = 79.3 bits (194), Expect = 7e-15
Identities = 74/282 (26%), Positives = 106/282 (37%), Gaps = 58/282 (20%)
Query: 80 LPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDP 139
LP L++++V+ D G+Y C ATN G L VL
Sbjct: 1846 LPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLV--------------------- 1884
Query: 140 ASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEP 199
P +P + + V+ +SV L+C+ASG P PD++W K Q ++
Sbjct: 1885 -------PPNIEPGPVNKAVLEN---ASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTV 1934
Query: 200 RKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATY--KVDVIQRTRSKPVLTGTHPVNTT 257
L ++ + D+G Y C SN AG+ Y +V+V R P L G VNT
Sbjct: 1935 SVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTP 1994
Query: 258 VDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDG 317
V C P + WLK +G N G V P G V
Sbjct: 1995 V------RLTCNATGAPSPTLMWLK------DG--NPVSPAGTPGLQVFPGGRV------ 2034
Query: 318 SYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP 359
L + AR D+G Y C+ + +G + L V P
Sbjct: 2035 -----LTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPP 2071
Score = 79.0 bits (193), Expect = 1e-14
Identities = 81/329 (24%), Positives = 124/329 (37%), Gaps = 71/329 (21%)
Query: 40 VARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG----LKVKQVEREDAG 95
V+R G V + CPV G PP W KDG + R L G L++ +V+ DAG
Sbjct: 3324 VSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQ---RTLLHGSGHTLRISKVQLADAG 3380
Query: 96 VYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKM 155
++ C A + G N+TL V P +P +
Sbjct: 3381 IFTCVAASPAGVADRNFTLQV----------------------------QVPPVLEPVEF 3412
Query: 156 RRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPED 215
+ V+ GS V L C A G P P ++WMKD + P ++ ++ +L L+ + D
Sbjct: 3413 QNDVVVVR-GSLVELPCEARGVPLPLVSWMKDGE----PLLSQSLEQGPSLQLEAVGAGD 3467
Query: 216 SGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVK 275
SG Y+C + AG +++ V++ + P ++ G C + +
Sbjct: 3468 SGTYSCVAVSEAGEARRHFQLTVMEPPH---IEDSGQPTELSLTPGAPMELLCDAQGTPQ 3524
Query: 276 PVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGM 335
P I W K GQ L +R + R R DAG+
Sbjct: 3525 PNITWHK----------------DGQALTRLENNSRATR----------VLRVR--DAGL 3556
Query: 336 YICLGANTMGYSFRSAFLTVLPDPKPPGP 364
Y CL + G +S + V P GP
Sbjct: 3557 YTCLAESPAGAIEKSFRVRVQAPPNIVGP 3585
Score = 78.6 bits (192), Expect = 1e-14
Identities = 106/415 (25%), Positives = 156/415 (37%), Gaps = 99/415 (23%)
Query: 44 GRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKVKQVEREDAGVYVCKAT 102
G V++ C G P P W+++ + + SR V QG L ++ V EDAG Y C+AT
Sbjct: 622 GVEVKVSCSASGYPTPHISWSRESQALQED-SRIHVDAQGTLIIQGVAPEDAGNYSCQAT 680
Query: 103 NGFGSLSVNYTLVVLDD-----------ISPGKES------------------------L 127
N G+ TL D ++ G+E+ L
Sbjct: 681 NEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMIL 740
Query: 128 GPDSSSGGQ-EDPASQQWARPRFT----------------------QPSKMRRRVIARPV 164
P+ SS G+ PA+Q+ +T Q +++ R V +
Sbjct: 741 APEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVE-L 799
Query: 165 GSSVRLKCVASGHPRPDITWMKDDQA-----LTRPEAAEPRKK-KWTLSLKNLRPEDSGK 218
G S L C A+G P P +TW + D L + R+ L +++ PED
Sbjct: 800 GRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAP 859
Query: 219 YTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVK-PV 277
Y C N G + A ++ I + P + + P ++ G S C V + P
Sbjct: 860 YVCEARNVFGKVQAEARL--IVTGHAPPQIASSAPTVRVLE-GQPVSLPCIVLAGRPLPE 916
Query: 278 IQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWS-RPDGSYLNKLLITRARQDDAGMY 336
WLK +GR LP G S R DGS L + RA Q+ AG Y
Sbjct: 917 RHWLK------DGRP-------------LPPGSRHSIRADGS----LHLDRALQEHAGRY 953
Query: 337 ICLGANTMGYSFRSAFLTVLPDPK---PPGPPVASSSSATSLPWPVVIGIPAGAV 388
C+ NT G R L V P+ + + SLP V G+PA +
Sbjct: 954 SCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPC-VASGVPAPTI 1007
Score = 77.0 bits (188), Expect = 4e-14
Identities = 82/351 (23%), Positives = 125/351 (35%), Gaps = 73/351 (20%)
Query: 44 GRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWS---RFRVLPQGLKVKQVEREDAGVYVCK 100
G+ VRL C +G PPP W KDG + RF + L +K + DAG Y C
Sbjct: 3232 GQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCV 3291
Query: 101 ATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVI 160
A N G + +T+ VL P G D S ++
Sbjct: 3292 AHNPAGEDARLHTVNVL---VPPTIKQGADGSG------------------------TLV 3324
Query: 161 ARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYT 220
+RP G V + C G P ++W+KD L + TL + ++ D+G +T
Sbjct: 3325 SRP-GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFT 3383
Query: 221 CRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDF-GGTTSFQCKVRSDVKPVIQ 279
C ++ AG + + + V + PVL N V G C+ R P++
Sbjct: 3384 CVAASPAGVADRNFTLQV----QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVS 3439
Query: 280 WLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICL 339
W+K E + +++ G L + D+G Y C+
Sbjct: 3440 WMK----DGEPLLSQSLEQG---------------------PSLQLEAVGAGDSGTYSCV 3474
Query: 340 GANTMGYSFRSAFLTVLPDPK------------PPGPPVASSSSATSLPWP 378
+ G + R LTV+ P PG P+ A P P
Sbjct: 3475 AVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQP 3525
Score = 75.9 bits (185), Expect = 8e-14
Identities = 74/323 (22%), Positives = 124/323 (38%), Gaps = 58/323 (17%)
Query: 42 RLGRTVRLQCPVEGDPPPLTMWTKDGRTIH---SGWSRFRVLPQGLKVKQVEREDAGVYV 98
R G L C G P P W KDG+ + +G + + L + Q + G Y
Sbjct: 2175 REGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYT 2234
Query: 99 CKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRR 158
C+ +N G+ S + L E P +G +E P TQ S ++
Sbjct: 2235 CECSNVVGNSSQDLQL----------EVHVPPQIAGPREPP----------TQVSVVQDG 2274
Query: 159 VIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGK 218
V L+C A+G P P +TW +D Q + + + + +L ++ + +G+
Sbjct: 2275 VAT--------LECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGR 2326
Query: 219 YTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHP--VNTTVDFGGTTSFQCKVRSDVKP 276
Y+C N AG +++ V+ P L G N T + C+ P
Sbjct: 2327 YSCVAENLAGRAERKFELSVL----VPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPP 2382
Query: 277 VIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMY 336
I+W + E + G + G W L +T+ ++ D+G+Y
Sbjct: 2383 AIRWFRGEEPVSPGEDTYLLAGG------------W---------MLKMTQTQEQDSGLY 2421
Query: 337 ICLGANTMGYSFRSAFLTVLPDP 359
CL +N G + R+ + VL P
Sbjct: 2422 SCLASNEAGEARRNFSVEVLVPP 2444
Score = 74.7 bits (182), Expect = 2e-13
Identities = 98/410 (23%), Positives = 147/410 (35%), Gaps = 69/410 (16%)
Query: 43 LGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCK 100
+G+ + L C G P P W ++GR + +V QG L + VE + +G++ C+
Sbjct: 1703 VGQPLELPCQASGSPVPTIQWLQNGRPAEE-LAGVQVASQGTTLHIDHVELDHSGLFACQ 1761
Query: 101 ATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVI 160
ATN G+ + V + +PG + G E +S P P +
Sbjct: 1762 ATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSF----PAACDPP------V 1811
Query: 161 ARPVGSSVRLKCVASGHPRPDIT--WMKDDQALTRPEAAEPRKK-KWTLSLKNLRPEDSG 217
R G+ HP+P + W P L ++ + D G
Sbjct: 1812 HRGWGA----------HPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEG 1861
Query: 218 KYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPV 277
YTC +N AG + V+ +P PVN V + + +C P
Sbjct: 1862 IYTCAATNLAGESKREVALKVLVPPNIEP-----GPVNKAVLENASVTLECLASGVPPPD 1916
Query: 278 IQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYI 337
+ W K + T+ V G+ L I +A+ DAG Y
Sbjct: 1917 VSWFKGHQ-PVSSWMGVTVSVDGRV--------------------LRIEQAQLSDAGSYR 1955
Query: 338 CLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIP----AGAVFILGT 393
C+ +N G + L V P+ PP SLP PV++ P A
Sbjct: 1956 CVASNVAGSTELRYGLRVNVPPRITLPP--------SLPGPVLVNTPVRLTCNATGAPSP 2007
Query: 394 LLLWLCQAQKKPCTPAPAPPL---PGHRPPGTARDRSGDKDLPSLAALSA 440
L+WL P +PA P L PG R A R+ D S A+SA
Sbjct: 2008 TLMWL--KDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSA 2055
Score = 74.3 bits (181), Expect = 2e-13
Identities = 84/335 (25%), Positives = 116/335 (34%), Gaps = 73/335 (21%)
Query: 44 GRTVRLQCPVEGDPPPLTMWTK--DGRTIHSGWSRFRVLPQG-LKVKQVEREDAGVYVCK 100
G L CP G P P W K +H G VL +G L + V D+G Y C+
Sbjct: 1221 GENASLPCPARGTPKPQVTWRKGPSSEPLH-GQPGVAVLEEGSLFLASVSPADSGDYECQ 1279
Query: 101 ATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVI 160
ATN GS S LVV + P G R+ +
Sbjct: 1280 ATNEVGSTSRRAKLVVY---------VPPSIREDG--------------------RKANV 1310
Query: 161 ARPVGSSVRLKCVASGHPRPDITWMKDDQALTRP--EAAEPRKKKW-------------T 205
+ G S+ L+C A+G P P+I W+KD Q + P A W +
Sbjct: 1311 SGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQS 1370
Query: 206 LSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGT-T 264
L ++ DSG Y+CR N+AG + + V+ + P + G + G
Sbjct: 1371 LHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVL----TPPSVLGAGAAQEVLGLAGADV 1426
Query: 265 SFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLL 324
QC P ++W K + GG V G V L
Sbjct: 1427 ELQCWTSGVPTPQVEWTK---------DRQPVLPGGPHLQVQEDGQV-----------LR 1466
Query: 325 ITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP 359
IT + D G Y C+ + G R L V P
Sbjct: 1467 ITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPP 1501
Score = 74.3 bits (181), Expect = 2e-13
Identities = 78/302 (25%), Positives = 110/302 (36%), Gaps = 57/302 (18%)
Query: 47 VRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG---LKVKQVEREDAGVYVCKATN 103
V+L C G P P W KDG + + S V +G L++ + + DAGVY CKA+N
Sbjct: 1520 VQLLCEARGVPTPNITWFKDGALLPT--STKVVYTRGGRQLQLGRAQSSDAGVYTCKASN 1577
Query: 104 GFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARP 163
G+ L V + P E G R V+
Sbjct: 1578 AVGAAEKATRLDVY--VPPTIEGAGG--------------------------RPYVVKAV 1609
Query: 164 VGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRV 223
G V L+CVA GHP P ++W + + + L L++ SG Y+C
Sbjct: 1610 AGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVA 1669
Query: 224 SNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKR 283
S+ AG Y V+V Q V G V T V G C+ P IQWL+
Sbjct: 1670 SSPAGEAVLQYSVEV-QVPPQLLVAEGLGQVTTIV--GQPLELPCQASGSPVPTIQWLQN 1726
Query: 284 VEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANT 343
G + + V Q G+ L+ I D +G++ C N
Sbjct: 1727 ---GRPAEELAGVQVASQ---------------GTTLH---IDHVELDHSGLFACQATNE 1765
Query: 344 MG 345
G
Sbjct: 1766 AG 1767
Score = 73.2 bits (178), Expect = 5e-13
Identities = 91/402 (22%), Positives = 144/402 (35%), Gaps = 90/402 (22%)
Query: 7 LLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKD 66
L +LL P +LG G AD+ V + + L C P P W KD
Sbjct: 2531 LSVLLAPTILG---------GAEDSADEEV---TVTVNNPISLICEALAFPSPNITWMKD 2578
Query: 67 GRTIHSGWSRFRVLP--QGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGK 124
G + ++LP GL++ ++EDAG Y C TN G NY + VL I P
Sbjct: 2579 GAPFEAS-RNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVL--IPP-- 2633
Query: 125 ESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITW 184
S ++DP + + + V S++ L+C + P P I W
Sbjct: 2634 --------SISKDDPLGEVGVKE------------VKTKVNSTLTLECESWAVPPPTIRW 2673
Query: 185 MKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRS 244
KD Q +T + + L ++ + DSG+Y C +N AG + + V + +
Sbjct: 2674 YKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI----QV 2729
Query: 245 KPVLTGTHPVNTTVDF--------GGTTSFQ-----------CKVRSDVKPVIQWLKRVE 285
P+ + + GG T ++ C + P + W + +
Sbjct: 2730 PPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQ 2789
Query: 286 YGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMG 345
+ G S + G L I R ++AG Y C +N +G
Sbjct: 2790 PLSAGDEVSVLQGG---------------------RVLQIPLVRAENAGRYSCKASNEVG 2828
Query: 346 YSFRSAFLTVLPDPKPPGPP-------VASSSSATSLPWPVV 380
+ L VL P G ++SS SL P +
Sbjct: 2829 EDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPAL 2870
Score = 72.8 bits (177), Expect = 7e-13
Identities = 98/404 (24%), Positives = 139/404 (34%), Gaps = 92/404 (22%)
Query: 7 LLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKD 66
LL+L PP +LGA AA+ +A G V LQC G P P WTKD
Sbjct: 1401 LLVLTPPSVLGA----GAAQEVLGLA-----------GADVELQCWTSGVPTPQVEWTKD 1445
Query: 67 GRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGK 124
+ + G +V G L++ D G Y C A + G + ++ L V
Sbjct: 1446 RQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVH------- 1498
Query: 125 ESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITW 184
P + G E +A V+L C A G P P+ITW
Sbjct: 1499 ---APPTIWGSNETGE-------------------VAVMEDHLVQLLCEARGVPTPNITW 1536
Query: 185 MKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRS 244
KD L + L L + D+G YTC+ SN GA ++DV
Sbjct: 1537 FKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY----V 1592
Query: 245 KPVLTGT--HPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQK 302
P + G P G + +C R P + W H+ + V
Sbjct: 1593 PPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSW-----------HHEGLPVAESN 1641
Query: 303 FVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPP 362
L T DGS L + + +G+Y C+ ++ P
Sbjct: 1642 ESRLET-------DGSVLR---LESPGEASSGLYSCVASS------------------PA 1673
Query: 363 GPPVASSSSATSLPWPVVIGIPAGAV-FILGTLLLWLCQAQKKP 405
G V S +P +++ G V I+G L CQA P
Sbjct: 1674 GEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSP 1717
Score = 68.9 bits (167), Expect = 1e-11
Identities = 82/321 (25%), Positives = 112/321 (34%), Gaps = 57/321 (17%)
Query: 47 VRLQCPVEGDPPPLTMWTKDGRTIH-SGWSRFRVLPQG--LKVKQVEREDAGVYVCKATN 103
VRL C G P P MW KDG + +G +V P G L + D+G Y C A +
Sbjct: 1995 VRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVS 2054
Query: 104 GFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARP 163
G + L V P S G ++ V+A
Sbjct: 2055 AVGEDRQDVVLQVHM----------PPSILG------------------EELNVSVVAN- 2085
Query: 164 VGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRV 223
SV L+C + P P ++W KD + L K L + D+G YTC
Sbjct: 2086 --ESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEA 2143
Query: 224 SNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKR 283
N+AG Y ++V PV TV G TS C+ R P I W K
Sbjct: 2144 LNQAGHSEKHYNLNV----WVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRK- 2198
Query: 284 VEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANT 343
GQ LP + + L + +A+ G Y C +N
Sbjct: 2199 ---------------DGQP---LPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNV 2240
Query: 344 MGYSFRSAFLTVLPDPKPPGP 364
+G S + L V P+ GP
Sbjct: 2241 VGNSSQDLQLEVHVPPQIAGP 2261
Score = 36.2 bits (82), Expect = 0.072
Identities = 43/176 (24%), Positives = 63/176 (35%), Gaps = 40/176 (22%)
Query: 215 DSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDV 274
+ G Y C +RAG A ++ V T P L N TV G T C+V +
Sbjct: 490 EEGTYECTAVSRAGTGRAKAQIVV---TDPPPQLVPAP--NVTVSPGETAVLSCRVLGEA 544
Query: 275 KPVIQWLK--RVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDD 332
+ W++ RV + GR D+ + ++PT D
Sbjct: 545 PYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPT-----------------------D 581
Query: 333 AGMYICLGANTMGYSFRSAFLTVLPDPK----------PPGPPVASSSSATSLPWP 378
G Y C+ +N G + S +L V P+ G V S SA+ P P
Sbjct: 582 GGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTP 637
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 105 bits (262), Expect = 1e-22
Identities = 92/342 (26%), Positives = 141/342 (41%), Gaps = 59/342 (17%)
Query: 28 PPKMADKVVPRQVARL-GRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--L 84
PP M + + ++ L G + + C +G P P W +DG+ + + V G L
Sbjct: 3433 PPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLD-AHLTVSTHGMVL 3491
Query: 85 KVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQW 144
++ + E ED+G Y C A+N G +S ++ L VL+ P +G +E
Sbjct: 3492 QLLKAETEDSGKYTCIASNEAGEVSKHFILKVLE----------PPHINGSEE------- 3534
Query: 145 ARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKW 204
I+ V + + L C+ASG P P +TWMKD + L + + +
Sbjct: 3535 ------------HEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGE 3582
Query: 205 TLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGT-HPVNTTVDFGGT 263
L + + ED+G+YTC S+ AG + Y V R P + GT P + TV
Sbjct: 3583 VLRISTAQVEDTGRYTCLASSPAGDDDKEYLV----RVHVPPNIAGTDEPRDITVLRNRQ 3638
Query: 264 TSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKL 323
+ +CK + PVI WL+ G++ P + S G YL
Sbjct: 3639 VTLECKSDAVPPPVITWLR----------------NGERLQATPRVRILS--GGRYLQ-- 3678
Query: 324 LITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPP 365
I A D Y C+ +N G + R LTV P G P
Sbjct: 3679 -INNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGP 3719
Score = 100 bits (248), Expect = 4e-21
Identities = 84/321 (26%), Positives = 122/321 (38%), Gaps = 58/321 (18%)
Query: 44 GRTVRLQCPVEGDPPPLTMWTKDGRTIHS-GWSRFRVLPQG--LKVKQVEREDAGVYVCK 100
G + L C G PPP +W K G + + R R+L G L++ E+ DA +Y C
Sbjct: 2211 GNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCV 2270
Query: 101 ATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVI 160
A+N G+ Y L Q + RP T +I
Sbjct: 2271 ASNVAGTAKKEYNL---------------------------QVYIRPTITNSGSHPTEII 2303
Query: 161 ARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYT 220
G S+ L+C G P P +TWMKD L + + E + L LKN+ D+G+Y
Sbjct: 2304 VTR-GKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYV 2362
Query: 221 CRVSNRAGAINATYKVDVIQRTRSKPVLTGTH--PVNTTVDFGGTTSFQCKVRSDVKPVI 278
C N AG + Y + V + P + G H P N +V + S C+ P I
Sbjct: 2363 CVAVNVAGMTDKKYDLSV----HAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSI 2418
Query: 279 QWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYIC 338
W K + NS + G + L + + +DAG Y C
Sbjct: 2419 TWFK--DGWPVSLSNSVRILSGGRM-------------------LRLMQTTMEDAGQYTC 2457
Query: 339 LGANTMGYSFRSAFLTVLPDP 359
+ N G + L+VL P
Sbjct: 2458 VVRNAAGEERKIFGLSVLVPP 2478
Score = 96.7 bits (239), Expect = 4e-20
Identities = 84/319 (26%), Positives = 120/319 (37%), Gaps = 55/319 (17%)
Query: 43 LGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCK 100
+ + L C PPP W KDG + S + +LP G L++ + + EDAG Y C
Sbjct: 2791 INNPISLYCETNAAPPPTLTWYKDGHPLTSS-DKVLILPGGRVLQIPRAKVEDAGRYTCV 2849
Query: 101 ATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVI 160
A N G S+ Y + VL P G D + +
Sbjct: 2850 AVNEAGEDSLQYDVRVLV----------PPIIKGANSDLPEE-----------------V 2882
Query: 161 ARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYT 220
V S ++C++SG P P +W KD Q L + + L + N + D G+Y
Sbjct: 2883 TVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYV 2942
Query: 221 CRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQW 280
C N AG+ + ++V P + G N TV S C+V P + W
Sbjct: 2943 CVAENTAGSAKKYFNLNV----HVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSW 2998
Query: 281 LKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLG 340
LK E + N+ I GG+ L I RA+ D G Y C+
Sbjct: 2999 LKN-EQPIKLNTNTLIVPGGR--------------------TLQIIRAKVSDGGEYTCIA 3037
Query: 341 ANTMGYSFRSAFLTVLPDP 359
N G S + LTV P
Sbjct: 3038 INQAGESKKKFSLTVYVPP 3056
Score = 95.9 bits (237), Expect = 8e-20
Identities = 91/323 (28%), Positives = 125/323 (38%), Gaps = 59/323 (18%)
Query: 42 RLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVC 99
R G +V L+C PPP+ W K+GR I + +L G L +K+ E D G YVC
Sbjct: 3072 REGTSVSLECESNAVPPPVITWYKNGRMITES-THVEILADGQMLHIKKAEVSDTGQYVC 3130
Query: 100 KATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRV 159
+A N G N+ L V + P E GP+ R V
Sbjct: 3131 RAINVAGRDDKNFHLNVY--VPPSIE--GPE--------------------------REV 3160
Query: 160 IARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPE--DSG 217
I + + V L C A+G P P I W+K+ + + ++ E R L+ R + DSG
Sbjct: 3161 IVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSG 3220
Query: 218 KYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTH-PVNTTVDFGGTTSFQCKVRSDVKP 276
YTC SN G Y + + + P + G P + +V G C P
Sbjct: 3221 NYTCIASNMEGKAQKYYFLSI----QVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTP 3276
Query: 277 VIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMY 336
+IQWLK + A G T + +GS LN I A D G Y
Sbjct: 3277 LIQWLKDGKPIASGE----------------TERIRVSANGSTLN---IYGALTSDTGKY 3317
Query: 337 ICLGANTMGYSFRSAFLTVLPDP 359
C+ N G R L V P
Sbjct: 3318 TCVATNPAGEEDRIFNLNVYVTP 3340
Score = 94.4 bits (233), Expect = 2e-19
Identities = 91/347 (26%), Positives = 130/347 (37%), Gaps = 62/347 (17%)
Query: 16 LGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWS 75
L P RGP + +V G+ V + C +G P P+ W+K G T+
Sbjct: 1165 LNVHVPPKIQRGPKHLKVQV--------GQRVDIPCNAQGTPLPVITWSKGGSTMLVDGE 1216
Query: 76 RFRVLPQG-LKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSG 134
P G L + Q DAG+Y C ATN G+ TL V + P E L P ++
Sbjct: 1217 HHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQE--PPTVEDLEPPYNTT 1274
Query: 135 GQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRP 194
QE A+Q+ + C A G P+P I W+ + + LT
Sbjct: 1275 FQERVANQR------------------------IEFPCPAKGTPKPTIKWLHNGRELTGR 1310
Query: 195 EAAEPRKKKWT-LSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHP 253
E + T L + ++ P D+G+Y C N AG Y + V PV+
Sbjct: 1311 EPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKV----HVPPVIKDKEQ 1366
Query: 254 V-NTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVW 312
V N +V T+ C+V P+I W K E T++ G
Sbjct: 1367 VTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNG------------- 1413
Query: 313 SRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP 359
L + RA +DAG Y C N G S + + VL P
Sbjct: 1414 --------KILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPP 1452
Score = 93.2 bits (230), Expect = 5e-19
Identities = 84/338 (24%), Positives = 131/338 (38%), Gaps = 56/338 (16%)
Query: 28 PPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--LK 85
PP + + +V + V LQC G P P W KD + +++ ++ G L+
Sbjct: 1825 PPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQ 1884
Query: 86 VKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWA 145
+ + EDAG Y C ATN G + L V +
Sbjct: 1885 IAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEP-------------------------- 1918
Query: 146 RPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWT 205
P KM + V + V+L+C A+G+P P ITW KD++ L+ + +
Sbjct: 1919 -PSLEDAGKMLNETVL--VSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQI 1975
Query: 206 LSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTS 265
+ +++ + D+G Y C N AGA Y + V P ++G++ + V
Sbjct: 1976 IDIESAQISDAGIYKCVAINSAGATELFYSLQV----HVAPSISGSNNM-VAVVVNNPVR 2030
Query: 266 FQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLI 325
+C+ R P + WLK +G S+ G Q VL G + L +
Sbjct: 2031 LECEARGIPAPSLTWLK------DGSPVSSFSNGLQ---VLSGGRI-----------LAL 2070
Query: 326 TRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPG 363
T A+ D G Y C+ N G R L V P G
Sbjct: 2071 TSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMG 2108
Score = 92.0 bits (227), Expect = 1e-18
Identities = 86/323 (26%), Positives = 123/323 (38%), Gaps = 57/323 (17%)
Query: 44 GRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCKA 101
G+++ L+C V+G PPP W KDG + +L +G L++K + D G YVC A
Sbjct: 2307 GKSISLECEVQGIPPPTVTWMKDGHPLIKA-KGVEILDEGHILQLKNIHVSDTGRYVCVA 2365
Query: 102 TNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIA 161
N G Y L V P S G P + I+
Sbjct: 2366 VNVAGMTDKKYDLSVH----------APPSIIGNHRSPEN------------------IS 2397
Query: 162 RPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTC 221
+SV L C ASG P P ITW KD ++ + L L ED+G+YTC
Sbjct: 2398 VVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTC 2457
Query: 222 RVSNRAGAINATYKVDVIQRTRSKPVLTGTHPV-NTTVDFGGTTSFQCKVRSDVKPVIQW 280
V N AG + + V+ P + G + + + V + + C+V + P I W
Sbjct: 2458 VVRNAAGEERKIFGLSVL----VPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITW 2513
Query: 281 LKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLG 340
K + E + I G +F L IT + G Y CL
Sbjct: 2514 HKDGQPLQEDEAHHII--SGGRF-------------------LQITNVQVPHTGRYTCLA 2552
Query: 341 ANTMGYSFRSAFLTVLPDPKPPG 363
++ G+ RS L V P G
Sbjct: 2553 SSPAGHKSRSFSLNVFVSPTIAG 2575
Score = 90.9 bits (224), Expect = 2e-18
Identities = 89/336 (26%), Positives = 126/336 (37%), Gaps = 56/336 (16%)
Query: 28 PPKMADKVVPRQVA-RLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSG-WSRFRVLPQG-- 83
PP +A +P V+ LG V L C G P PL W KDG+ I SG R RV G
Sbjct: 3244 PPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGST 3303
Query: 84 LKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQ 143
L + D G Y C ATN G + L V ++P + G +D A +
Sbjct: 3304 LNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVY--VTP---------TIRGNKDEAEK- 3351
Query: 144 WARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKK 203
+ V +S+ ++C A+G P P I W+K+ L
Sbjct: 3352 ----------------LMTLVDTSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAG 3395
Query: 204 WTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGT 263
+ + + D YTC SNRAG N Y + V + GT + TV G +
Sbjct: 3396 QVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSM-GTEEI--TVLKGSS 3452
Query: 264 TSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKL 323
TS C P + WL+ + H T+ G L
Sbjct: 3453 TSMACITDGTPAPSMAWLRDGQPLGLDAH-LTVSTHGM--------------------VL 3491
Query: 324 LITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP 359
+ +A +D+G Y C+ +N G + L VL P
Sbjct: 3492 QLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPP 3527
Score = 89.4 bits (220), Expect = 7e-18
Identities = 87/366 (23%), Positives = 132/366 (36%), Gaps = 69/366 (18%)
Query: 28 PPKMADKVVPRQVARL-GRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--L 84
PP +A PR + L R V L+C + PPP+ W ++G + + R R+L G L
Sbjct: 3619 PPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQAT-PRVRILSGGRYL 3677
Query: 85 KVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQW 144
++ + D Y C A+N G + + L V ++ P+ G Q
Sbjct: 3678 QINNADLGDTANYTCVASNIAGKTTREFILTV---------NVPPNIKGGPQS------- 3721
Query: 145 ARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKW 204
+ + S L+C+A G P P ITW KD L A +
Sbjct: 3722 ---------------LVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENG 3766
Query: 205 TLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTT 264
L +++ D+G+Y C +N AG + V P P N TV T
Sbjct: 3767 FLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQV-----HVPPSIAPGPTNMTVIVNVQT 3821
Query: 265 SFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLL 324
+ C+ KP I W K H +D + +L +G L+
Sbjct: 3822 TLACEATGIPKPSINWRK-------NGHLLNVDQNQNSYRLLSSG------------SLV 3862
Query: 325 ITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPK----------PPGPPVASSSSATS 374
I DD Y C N G R+ LTV P P + +A+
Sbjct: 3863 IISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASG 3922
Query: 375 LPWPVV 380
+P+P +
Sbjct: 3923 VPFPSI 3928
Score = 89.0 bits (219), Expect = 9e-18
Identities = 95/362 (26%), Positives = 134/362 (37%), Gaps = 87/362 (24%)
Query: 49 LQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKVKQVEREDAGVYVCKATNGFG- 106
L C +G P P W KD + + ++ P G L ++ V ED+G Y C A N G
Sbjct: 4188 LPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGE 4247
Query: 107 -SLSVNYTLVVLDDIS--PGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARP 163
+ +V+ T+ VL + PG SL
Sbjct: 4248 DTHTVSLTVHVLPTFTELPGDVSLNK---------------------------------- 4273
Query: 164 VGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRV 223
G +RL C A+G P P +TW ++ + P + L ++ + EDSG Y C
Sbjct: 4274 -GEQLRLSCKATGIPLPKLTWTFNNNII--PAHFDSVNGHSELVIERVSKEDSGTYVCTA 4330
Query: 224 SNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKR 283
N G + A V V + PV G +P N GG C+V+ D P IQW
Sbjct: 4331 ENSVGFVKAIGFVYV----KEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQW--- 4383
Query: 284 VEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANT 343
R I++ + + +GS L I +DAG Y C+ N
Sbjct: 4384 ------NRKGVDIEISHR---------IRQLGNGS----LAIYGTVNEDAGDYTCVATNE 4424
Query: 344 MGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWLCQAQK 403
G RS LT+ PP+ + PV I AG IL CQA
Sbjct: 4425 AGVVERSMSLTL------QSPPIITLE-------PVETVINAGGKIILN------CQATG 4465
Query: 404 KP 405
+P
Sbjct: 4466 EP 4467
Score = 88.2 bits (217), Expect = 2e-17
Identities = 84/352 (23%), Positives = 126/352 (35%), Gaps = 62/352 (17%)
Query: 28 PPKMADKVVPRQVARLGRT----VRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG 83
PP + D P R + CP +G P P W +GR + +L G
Sbjct: 1261 PPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDG 1320
Query: 84 --LKVKQVEREDAGVYVCKATNGFGSLSVNYTLVV-LDDISPGKESLGPDSSSGGQEDPA 140
L + V D G Y+C A N G+ Y L V + + KE +
Sbjct: 1321 TLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQV------------- 1367
Query: 141 SQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPR 200
T S + ++ L C G P P I W KD+ +T +
Sbjct: 1368 ---------TNVSVLLNQL--------TNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTV 1410
Query: 201 KKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTH-PVNTTVD 259
L L PED+G+Y+C+ N AG + +DV+ P + GT+ P +V
Sbjct: 1411 NNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVL----VPPTIIGTNFPNEVSVV 1466
Query: 260 FGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSY 319
+ +C+V+ P I W K + +G +L G V
Sbjct: 1467 LNRDVALECQVKGTPFPDIHWFK---------DGKPLFLGDPNVELLDRGQV-------- 1509
Query: 320 LNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSS 371
L + AR++D G Y C +N G + LT+ P G V + S
Sbjct: 1510 ---LHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDIS 1558
Score = 87.8 bits (216), Expect = 2e-17
Identities = 89/372 (23%), Positives = 137/372 (36%), Gaps = 75/372 (20%)
Query: 28 PP--KMADKVVPRQVARL-GRTVRLQCPVEGDPPPLTMWTKDGRTI-----HSGWSRFRV 79
PP K A+ +P +V L ++ ++C G P P W KDG+ + H S R+
Sbjct: 2868 PPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRI 2927
Query: 80 LPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDP 139
L++ + D G YVC A N GS + L ++ +GP S +
Sbjct: 2928 ----LQILNTQITDIGRYVCVAENTAGSAKKYFNL----NVHVPPSVIGPKSEN------ 2973
Query: 140 ASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEP 199
+ V + + L C SG P PD++W+K++Q +
Sbjct: 2974 --------------------LTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLI 3013
Query: 200 RKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVD 259
TL + + D G+YTC N+AG + + V K + + V V
Sbjct: 3014 VPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSV-VNVR 3072
Query: 260 FGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSY 319
G + S +C+ + PVI W K E H + DG
Sbjct: 3073 EGTSVSLECESNAVPPPVITWYKNGRMITESTHVEIL------------------ADGQM 3114
Query: 320 LNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGP-----------PVAS 368
L+ I +A D G Y+C N G ++ L V P GP PV
Sbjct: 3115 LH---IKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTL 3171
Query: 369 SSSATSLPWPVV 380
+ AT +P P +
Sbjct: 3172 TCDATGIPPPTI 3183
Score = 87.0 bits (214), Expect = 4e-17
Identities = 89/350 (25%), Positives = 131/350 (37%), Gaps = 75/350 (21%)
Query: 43 LGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKVKQVEREDAGVYVCKA 101
L + L C G P P W K+G +++ VLP G L++ + REDAG Y+C A
Sbjct: 4001 LNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVA 4060
Query: 102 TNGFGSL--SVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRV 159
N G+ + + V ISP ++ V
Sbjct: 4061 QNPAGTALGKIKLNVQVPPVISP-------------------------------HLKEYV 4089
Query: 160 IARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPR-KKKWTLSLKNLRPEDSGK 218
IA V + L C A G P PDITW KD +A+ E+ R +L + ++P D+G
Sbjct: 4090 IA--VDKPITLSCEADGLPPPDITWHKDGRAIV--ESIRQRVLSSGSLQIAFVQPGDAGH 4145
Query: 219 YTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVI 278
YTC +N AG+ + + K+ V P + T + TV+ C P I
Sbjct: 4146 YTCMAANVAGSSSTSTKLTV----HVPPRIRSTEG-HYTVNENSQAILPCVADGIPTPAI 4200
Query: 279 QWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYIC 338
W K N + K+ P G+ L++ +D+G Y C
Sbjct: 4201 NWKK---------DNVLLANLLGKYTAEPYGE------------LILENVVLEDSGFYTC 4239
Query: 339 LGANTMGYSFRSAFLTVLPDPK----------PPGPPVASSSSATSLPWP 378
+ N G + LTV P G + S AT +P P
Sbjct: 4240 VANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLP 4289
Score = 86.3 bits (212), Expect = 6e-17
Identities = 82/305 (26%), Positives = 120/305 (39%), Gaps = 59/305 (19%)
Query: 46 TVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCKATN 103
+V L C G P P W KDG + S R+L G L++ Q EDAG Y C N
Sbjct: 2403 SVSLTCEASGIPLPSITWFKDGWPVSLSNS-VRILSGGRMLRLMQTTMEDAGQYTCVVRN 2461
Query: 104 GFGSLSVNYTLVVLDDISP---GKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVI 160
G + L VL + P G+ +L + K++ +
Sbjct: 2462 AAGEERKIFGLSVL--VPPHIVGENTL-----------------------EDVKVKEK-- 2494
Query: 161 ARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYT 220
SV L C +G+P P+ITW KD Q L EA L + N++ +G+YT
Sbjct: 2495 -----QSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYT 2549
Query: 221 CRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQW 280
C S+ AG + ++ ++V V + +P + TV TS C+ S I W
Sbjct: 2550 CLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITW 2609
Query: 281 LKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLG 340
K + T + +LP G L I A++D+AG Y C+
Sbjct: 2610 FK----------DGTPLESNRNIRILPGG-----------RTLQILNAQEDNAGRYSCVA 2648
Query: 341 ANTMG 345
N G
Sbjct: 2649 TNEAG 2653
Score = 85.5 bits (210), Expect = 1e-16
Identities = 97/358 (27%), Positives = 136/358 (37%), Gaps = 64/358 (17%)
Query: 28 PPKMADKVVPRQVA-RLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--L 84
PP + DK V+ L + L C VEG P P+ MW KD + S + + G L
Sbjct: 1358 PPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTES-STIQTVNNGKIL 1416
Query: 85 KVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQW 144
K+ + EDAG Y CKA N G+ + + VL + P + G P
Sbjct: 1417 KLFRATPEDAGRYSCKAINIAGTSQKYFNIDVL--VPP---------TIIGTNFPNE--- 1462
Query: 145 ARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEA-AEPRKKK 203
++ + V L+C G P PDI W KD + L + E +
Sbjct: 1463 ---------------VSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRG 1507
Query: 204 WTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGT 263
L LKN R D G+Y C VSN AG K+ + K G + +V
Sbjct: 1508 QVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIK---GGNVTTDISVLINSL 1564
Query: 264 TSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKL 323
+C+ R P I W K GQ ++ + G YL+
Sbjct: 1565 IKLECETRGLPMPAITWYK----------------DGQP--IMSSSQALYIDKGQYLH-- 1604
Query: 324 LITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVI 381
I RA+ D+ Y C AN G + +S + V PP+ + AT L VVI
Sbjct: 1605 -IPRAQVSDSATYTCHVANVAGTAEKSFHVDVYV------PPMIEGNLATPLNKQVVI 1655
Score = 85.5 bits (210), Expect = 1e-16
Identities = 85/327 (25%), Positives = 127/327 (38%), Gaps = 56/327 (17%)
Query: 43 LGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCK 100
L L C PP W KDG + S R+LP G L++ + ++AG Y C
Sbjct: 2589 LNSPTSLVCEAYSYPPATITWFKDGTPLESN-RNIRILPGGRTLQILNAQEDNAGRYSCV 2647
Query: 101 ATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVI 160
ATN G + +Y + V + P + G P P +++ +V
Sbjct: 2648 ATNEAGEMIKHYEVKVY---------IPPIINKGDLWGPG---------LSPKEVKIKV- 2688
Query: 161 ARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYT 220
+++ L+C A P ++W KD Q L + TL +K + D+G+YT
Sbjct: 2689 ----NNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYT 2744
Query: 221 CRVSNRAGAINATYKVDVIQRTRSKPVL--------TGTHPVNTTVDFGGTTSFQCKVRS 272
C SN AG + V+ IQ S L TG + V S C+ +
Sbjct: 2745 CVASNIAGEDELDFDVN-IQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNA 2803
Query: 273 DVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDD 332
P + W K +G ++ D K ++LP G V L I RA+ +D
Sbjct: 2804 APPPTLTWYK------DGHPLTSSD----KVLILPGGRV-----------LQIPRAKVED 2842
Query: 333 AGMYICLGANTMGYSFRSAFLTVLPDP 359
AG Y C+ N G + VL P
Sbjct: 2843 AGRYTCVAVNEAGEDSLQYDVRVLVPP 2869
Score = 85.1 bits (209), Expect = 1e-16
Identities = 95/347 (27%), Positives = 133/347 (38%), Gaps = 68/347 (19%)
Query: 21 PAAAARGPPKMADKVVP-------RQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSG 73
PA A G K+ +V P V + + + L C +G PPP W KDGR I
Sbjct: 4063 PAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVES 4122
Query: 74 WSRFRVLPQG-LKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSS 132
R RVL G L++ V+ DAG Y C A N GS S + L V + P
Sbjct: 4123 -IRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTV--HVPP---------- 4169
Query: 133 SGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALT 192
R R T+ S L CVA G P P I W KD+ L
Sbjct: 4170 -------------RIRSTEGHYTVNE------NSQAILPCVADGIPTPAINWKKDNVLLA 4210
Query: 193 RPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTH 252
+ L L+N+ EDSG YTC +N AG T + V P T
Sbjct: 4211 NLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTV----HVLPTFTEL- 4265
Query: 253 PVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVW 312
P + +++ G CK P + W N+ I +P +
Sbjct: 4266 PGDVSLNKGEQLRLSCKATGIPLPKLTW----------TFNNNI---------IPAH--F 4304
Query: 313 SRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP 359
+G ++L+I R ++D+G Y+C N++G+ F+ V P
Sbjct: 4305 DSVNGH--SELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPP 4349
Score = 84.3 bits (207), Expect = 2e-16
Identities = 85/365 (23%), Positives = 141/365 (38%), Gaps = 72/365 (19%)
Query: 44 GRTVRLQCPV-EGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKVKQVEREDAGVYVCKA 101
G+ + L C + G+P P W K+ + V G L +++V+ +D G Y C A
Sbjct: 904 GQQLTLPCTLLAGNPIPERRWIKNSAMLLQN-PYITVRSDGSLHIERVQLQDGGEYTCVA 962
Query: 102 TNGFGSLSVNYTLVV--LDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRV 159
+N G+ + ++VV L I G++ +
Sbjct: 963 SNVAGTNNKTTSVVVHVLPTIQHGQQ---------------------------------I 989
Query: 160 IARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKY 219
++ G V L C ASG+P+P + W K + ++ A +L + + E+SG+Y
Sbjct: 990 LSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEY 1049
Query: 220 TCRVSNRAGAINATYKVDVIQRTR---SKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKP 276
C +N AG ++ V R R + L+ PV +V G + C+V+S P
Sbjct: 1050 VCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPP 1109
Query: 277 VIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMY 336
+I W K + I + LP+G + IT R D+GMY
Sbjct: 1110 IITWAKETQ---------LISPFSPRHTFLPSG------------SMKITETRTSDSGMY 1148
Query: 337 ICLGANTMGYSFRSAFLTVLPDPK----------PPGPPVASSSSATSLPWPVVIGIPAG 386
+C+ N G ++ L V PK G V +A P PV+ G
Sbjct: 1149 LCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGG 1208
Query: 387 AVFIL 391
+ ++
Sbjct: 1209 STMLV 1213
Score = 84.0 bits (206), Expect = 3e-16
Identities = 79/346 (22%), Positives = 127/346 (36%), Gaps = 53/346 (15%)
Query: 28 PPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--LK 85
PP + + + L C V G PPP W K+ + I + ++P G L+
Sbjct: 2963 PPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTL-IVPGGRTLQ 3021
Query: 86 VKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWA 145
+ + + D G Y C A N G ++L V + P + +S S
Sbjct: 3022 IIRAKVSDGGEYTCIAINQAGESKKKFSLTVY--VPPSIKDHDSESLS------------ 3067
Query: 146 RPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWT 205
V+ G+SV L+C ++ P P ITW K+ + +T E
Sbjct: 3068 -------------VVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQM 3114
Query: 206 LSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTS 265
L +K D+G+Y CR N AG + + ++V P + G +
Sbjct: 3115 LHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVY----VPPSIEGPEREVIVETISNPVT 3170
Query: 266 FQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLI 325
C P I WLK H + + +L G +KL I
Sbjct: 3171 LTCDATGIPPPTIAWLK--------NHKRIENSDSLEVRILSGG-----------SKLQI 3211
Query: 326 TRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSS 371
R++ D+G Y C+ +N G + + FL++ P G + S S
Sbjct: 3212 ARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVS 3257
Score = 80.5 bits (197), Expect = 3e-15
Identities = 72/325 (22%), Positives = 116/325 (35%), Gaps = 65/325 (20%)
Query: 43 LGRTVRLQCPVEGDPPPLTMWTKDGRTIHS----GWSRFRVLPQGLKVKQVEREDAGVYV 98
+ + V L C + PPP W KDG + S R + LK++ + +D G Y
Sbjct: 2117 ISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSV---LKIEDAQVQDTGRYT 2173
Query: 99 CKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRR 158
C+ATN G NY + + W P ++ +
Sbjct: 2174 CEATNVAGKTEKNYNVNI---------------------------WVPPNIGGSDELTQL 2206
Query: 159 VIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPR--KKKWTLSLKNLRPEDS 216
+ G+ + L C +SG P P++ W K + R L + D+
Sbjct: 2207 TVIE--GNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDA 2264
Query: 217 GKYTCRVSNRAGAINATYKVDVIQRTRSKPVLT--GTHPVNTTVDFGGTTSFQCKVRSDV 274
Y+C SN AG Y + V R P +T G+HP V G + S +C+V+
Sbjct: 2265 ALYSCVASNVAGTAKKEYNLQVYIR----PTITNSGSHPTEIIVTRGKSISLECEVQGIP 2320
Query: 275 KPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAG 334
P + W+K + + +D G + L + D G
Sbjct: 2321 PPTVTWMKDGHPLIKAKGVEILDEG---------------------HILQLKNIHVSDTG 2359
Query: 335 MYICLGANTMGYSFRSAFLTVLPDP 359
Y+C+ N G + + L+V P
Sbjct: 2360 RYVCVAVNVAGMTDKKYDLSVHAPP 2384
Score = 79.7 bits (195), Expect = 6e-15
Identities = 82/325 (25%), Positives = 125/325 (38%), Gaps = 57/325 (17%)
Query: 40 VARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWS-RFRVLPQG--LKVKQVEREDAGV 96
V + V L C G PPP W K+ + I + S R+L G L++ + + D+G
Sbjct: 3162 VETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGN 3221
Query: 97 YVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMR 156
Y C A+N G Y L S+ S G E P+
Sbjct: 3222 YTCIASNMEGKAQKYYFL-----------SIQVPPSVAGAEIPSD--------------- 3255
Query: 157 RRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPR--KKKWTLSLKNLRPE 214
++ +G +V L C A+G P P I W+KD + + E R TL++
Sbjct: 3256 ---VSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTS 3312
Query: 215 DSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDV 274
D+GKYTC +N AG + + ++V + + T VD + + +C+
Sbjct: 3313 DTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVD--TSINIECRATGTP 3370
Query: 275 KPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAG 334
P I WLK G +S I +L G V + I RA+ D
Sbjct: 3371 PPQINWLKN---GLPLPLSSHIR-------LLAAGQV-----------IRIVRAQVSDVA 3409
Query: 335 MYICLGANTMGYSFRSAFLTVLPDP 359
+Y C+ +N G + L V P
Sbjct: 3410 VYTCVASNRAGVDNKHYNLQVFAPP 3434
Score = 77.8 bits (190), Expect = 2e-14
Identities = 86/367 (23%), Positives = 136/367 (37%), Gaps = 67/367 (18%)
Query: 28 PPKMADKVVPRQVARL-GRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRV-LPQGLK 85
PP + V ++ L ++L+C G P P W KDG+ I S + Q L
Sbjct: 1545 PPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLH 1604
Query: 86 VKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWA 145
+ + + D+ Y C N G+ ++ + V P G P ++Q
Sbjct: 1605 IPRAQVSDSATYTCHVANVAGTAEKSFHVDV----------YVPPMIEGNLATPLNKQVV 1654
Query: 146 RPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWT 205
+ S+ L+C A+G+P P +TW+KD + +
Sbjct: 1655 ------------------IAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKK 1696
Query: 206 LSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVN-TTVDFGGTT 264
L + + + D G+Y C ++ AG Y+VDV+ P + G + V
Sbjct: 1697 LEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVL----VPPAIEGGDETSYFIVMVNNLL 1752
Query: 265 SFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLL 324
C V P I WLK +G+ D F +L G KL+
Sbjct: 1753 ELDCHVTGSPPPTIMWLK------DGQLIDERD----GFKILLNG-----------RKLV 1791
Query: 325 ITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP--KPPG---------PPVASSSSAT 373
I +A+ + G+Y C+ ANT G + +TV P K G PVA A
Sbjct: 1792 IAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIAN 1851
Query: 374 SLPWPVV 380
+P P +
Sbjct: 1852 GIPNPSI 1858
Score = 76.3 bits (186), Expect = 6e-14
Identities = 92/365 (25%), Positives = 132/365 (36%), Gaps = 64/365 (17%)
Query: 28 PPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKV 86
PP +AD+ V + V + C G P P WTK+G + +R+L G +++
Sbjct: 3896 PPSIADEPTDFLVTKHAPAV-ITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEI 3954
Query: 87 KQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWAR 146
+ AG Y C A N GS + TL V +
Sbjct: 3955 LATQLNHAGRYTCVARNAAGSAHRHVTLHVHE---------------------------- 3986
Query: 147 PRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTL 206
P QP VI + + + L C A+G P P ITW K+ + L
Sbjct: 3987 PPVIQPQPSELHVI---LNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGGL 4043
Query: 207 SLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSF 266
+ ED+G Y C N AG K++V P + H + +
Sbjct: 4044 QISRAVREDAGTYMCVAQNPAGTALGKIKLNV-----QVPPVISPHLKEYVIAVDKPITL 4098
Query: 267 QCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLIT 326
C+ P I W K +GR + ++ Q+ VL +G L I
Sbjct: 4099 SCEADGLPPPDITWHK------DGR--AIVESIRQR--VLSSG------------SLQIA 4136
Query: 327 RARQDDAGMYICLGANTMGYSFRSAFLTVLPDPK---PPGPPVASSSSATSLPWPVVIGI 383
+ DAG Y C+ AN G S S LTV P+ G + +S LP V GI
Sbjct: 4137 FVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPC-VADGI 4195
Query: 384 PAGAV 388
P A+
Sbjct: 4196 PTPAI 4200
Score = 74.3 bits (181), Expect = 2e-13
Identities = 68/303 (22%), Positives = 115/303 (37%), Gaps = 61/303 (20%)
Query: 44 GRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKATN 103
G +RL C G P P WT + I + + + L +++V +ED+G YVC A N
Sbjct: 4274 GEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSE-LVIERVSKEDSGTYVCTAEN 4332
Query: 104 GFGSL-SVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIAR 162
G + ++ + V + G PS
Sbjct: 4333 SVGFVKAIGFVYVKEPPVFKGD--------------------------YPSNW-----IE 4361
Query: 163 PVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCR 222
P+G + L C G P P I W + + + +L++ ED+G YTC
Sbjct: 4362 PLGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIR-QLGNGSLAIYGTVNEDAGDYTCV 4420
Query: 223 VSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLK 282
+N AG + + + + +S P++T PV T ++ GG C+ + +P I W +
Sbjct: 4421 ATNEAGVVERSMSLTL----QSPPIIT-LEPVETVINAGGKIILNCQATGEPQPTITWSR 4475
Query: 283 RVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGAN 342
+ H+ + D R + N L I A+++D + C+ N
Sbjct: 4476 Q-------GHSISWD---------------DRVNVLSNNSLYIADAQKEDTSEFECVARN 4513
Query: 343 TMG 345
MG
Sbjct: 4514 LMG 4516
Score = 73.9 bits (180), Expect = 3e-13
Identities = 75/334 (22%), Positives = 122/334 (36%), Gaps = 51/334 (15%)
Query: 37 PRQVA-RLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--LKVKQVERED 93
P++V ++ T+ L+C P W KDG+ + S + G L++K+ + D
Sbjct: 2681 PKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSD-DHVNIAANGHTLQIKEAQISD 2739
Query: 94 AGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPS 153
G Y C A+N G +++ + + + P + L G D A+
Sbjct: 2740 TGRYTCVASNIAGEDELDFDVNI--QVPPSFQKLW---EIGNMLDTGRNGEAKDVI---- 2790
Query: 154 KMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRP 213
+ + + L C + P P +TW KD LT + L + +
Sbjct: 2791 ----------INNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKV 2840
Query: 214 EDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTH---PVNTTVDFGGTTSFQCKV 270
ED+G+YTC N AG + Y V V+ P++ G + P TV + +C
Sbjct: 2841 EDAGRYTCVAVNEAGEDSLQYDVRVL----VPPIIKGANSDLPEEVTVLVNKSALIECLS 2896
Query: 271 RSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQ 330
P W K + E H+ + G L I +
Sbjct: 2897 SGSPAPRNSWQKDGQPLLEDDHHKFLSNG---------------------RILQILNTQI 2935
Query: 331 DDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGP 364
D G Y+C+ NT G + + L V P GP
Sbjct: 2936 TDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGP 2969
Score = 72.8 bits (177), Expect = 7e-13
Identities = 68/297 (22%), Positives = 113/297 (38%), Gaps = 45/297 (15%)
Query: 28 PPKMADKVVPRQVARLGRT-VRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LK 85
PPK+ V+P+ + G + V + C G P P WT + I G R+R+ G L
Sbjct: 611 PPKVT--VMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFI-VGSHRYRMTSDGTLF 667
Query: 86 VKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWA 145
+K +DAG+Y C A+N G+ N TL
Sbjct: 668 IKNAAPKDAGIYGCLASNSAGTDKQNSTL------------------------------- 696
Query: 146 RPRFTQPSKMR--RRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKK 203
R+ + K+ + + +G ++C SG P P + W K D L
Sbjct: 697 --RYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLL 754
Query: 204 WTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGT 263
L ++ + D+G YTC N AG +DV P + P + +++ G
Sbjct: 755 GLLKIQETQDLDAGDYTCVAINEAGRATGKITLDV-----GSPPVFIQEPADVSMEIGSN 809
Query: 264 TSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYL 320
+ C V+ +P I+W + R S + + L ++W+ G+Y+
Sbjct: 810 VTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYI 866
Score = 70.9 bits (172), Expect = 3e-12
Identities = 66/304 (21%), Positives = 107/304 (35%), Gaps = 54/304 (17%)
Query: 43 LGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWS-RFRVLPQGLKVKQVEREDAGVYVCKA 101
+ ++ L+C G+P P+ W KDG + + + R + L++ + D G Y+C A
Sbjct: 1655 IAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVA 1714
Query: 102 TNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIA 161
T+ G + Y + VL P + GG E
Sbjct: 1715 TSVAGEKEIKYEVDVLV----------PPAIEGGDETS-------------------YFI 1745
Query: 162 RPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTC 221
V + + L C +G P P I W+KD Q + + + L + + ++G Y C
Sbjct: 1746 VMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRC 1805
Query: 222 RVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWL 281
+N AG ++V V P + + V + QC P I WL
Sbjct: 1806 MAANTAGDHKKEFEVTV----HVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWL 1861
Query: 282 KRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGA 341
K + + N I G+ L I + +DAG Y C+
Sbjct: 1862 KDDQPVNTAQGNLKIQSSGR--------------------VLQIAKTLLEDAGRYTCVAT 1901
Query: 342 NTMG 345
N G
Sbjct: 1902 NAAG 1905
Score = 70.1 bits (170), Expect = 4e-12
Identities = 90/357 (25%), Positives = 132/357 (36%), Gaps = 76/357 (21%)
Query: 43 LGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGL---KVKQVEREDAGVYVC 99
LG ++C G PPP W K + S F ++ L K+++ + DAG Y C
Sbjct: 715 LGDITVMECKTSGIPPPQVKWFKGDLELRP--STFLIIDPLLGLLKIQETQDLDAGDYTC 772
Query: 100 KATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRV 159
A N G + GK +L S ++PA
Sbjct: 773 VAINEAGRAT-------------GKITLDVGSPPVFIQEPAD------------------ 801
Query: 160 IARPVGSSVRLKCVASGHPRPDITWMKDDQ--ALTRPEAAE--PRKKKWTLSLKNLRPED 215
++ +GS+V L C G+P P I W + D +RP + + + L + NL D
Sbjct: 802 VSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASD 861
Query: 216 SGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCK-VRSDV 274
G Y C N+ G I + V V T L G P V G + C + +
Sbjct: 862 KGTYICEAENQFGKIQSETTVTV---TGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNP 918
Query: 275 KPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAG 334
P +W+K NS ++L + R DGS L I R + D G
Sbjct: 919 IPERRWIK----------NSA--------MLLQNPYITVRSDGS----LHIERVQLQDGG 956
Query: 335 MYICLGANTMGYSFR--SAFLTVLPDPKP--------PGPPVASSSSATSLPWPVVI 381
Y C+ +N G + + S + VLP + G PV A+ P P VI
Sbjct: 957 EYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVI 1013
Score = 65.5 bits (158), Expect = 1e-10
Identities = 81/345 (23%), Positives = 124/345 (35%), Gaps = 79/345 (22%)
Query: 63 WTKDGRTIHSGW-SRFRVLPQ-GLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDI 120
W ++ R + +R R L L++K V+ DAG Y C ++ GS + + L V +
Sbjct: 553 WQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQE-- 610
Query: 121 SPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRP 180
P K ++ P + S FT GS V + C A+G+P+P
Sbjct: 611 -PPKVTVMPKNQS---------------FTG-------------GSEVSIMCSATGYPKP 641
Query: 181 DITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQ 240
I W +D + TL +KN P+D+G Y C SN AG + I+
Sbjct: 642 KIAWTVNDMFIVGSHRYR-MTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIE 700
Query: 241 RTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGG 300
+ V + V G T +CK P ++W K +++
Sbjct: 701 APKLMVVQS-----ELLVALGDITVMECKTSGIPPPQVKWFK-----------GDLELRP 744
Query: 301 QKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPK 360
F+++ L L I + DAG Y C+ N G + L V
Sbjct: 745 STFLII----------DPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDV----- 789
Query: 361 PPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWLCQAQKKP 405
G P PV I PA +G+ + C Q P
Sbjct: 790 --GSP------------PVFIQEPADVSMEIGSNVTLPCYVQGYP 820
Score = 58.9 bits (141), Expect = 1e-08
Identities = 50/204 (24%), Positives = 77/204 (37%), Gaps = 34/204 (16%)
Query: 28 PPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKV 86
PP + LG L C V+GDP P W + G I R R L G L +
Sbjct: 4348 PPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRKGVDIEIS-HRIRQLGNGSLAI 4406
Query: 87 KQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWAR 146
EDAG Y C ATN G + + +L + SP +L P +
Sbjct: 4407 YGTVNEDAGDYTCVATNEAGVVERSMSLTLQ---SPPIITLEPVET-------------- 4449
Query: 147 PRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTL 206
G + L C A+G P+P ITW + +++ + +L
Sbjct: 4450 --------------VINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNN-SL 4494
Query: 207 SLKNLRPEDSGKYTCRVSNRAGAI 230
+ + + ED+ ++ C N G++
Sbjct: 4495 YIADAQKEDTSEFECVARNLMGSV 4518
Score = 57.8 bits (138), Expect = 2e-08
Identities = 49/197 (24%), Positives = 78/197 (39%), Gaps = 28/197 (14%)
Query: 165 GSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRK-KKWTLSLKNLRPEDSGKYTCRV 223
G L C+ ++TW ++D+ + E A R +L LK+++ D+G+Y C V
Sbjct: 534 GERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMV 593
Query: 224 SNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKR 283
S+ G+ A+ + T +P P N + G S C KP I W
Sbjct: 594 SSEGGSSAAS-----VFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTV- 647
Query: 284 VEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANT 343
N VG ++ + G L I A DAG+Y CL +N+
Sbjct: 648 ---------NDMFIVGSHRYRMTSDG------------TLFIKNAAPKDAGIYGCLASNS 686
Query: 344 MGYSFRSAFLTVLPDPK 360
G +++ L + PK
Sbjct: 687 AGTDKQNSTLRYIEAPK 703
Score = 40.4 bits (93), Expect = 0.004
Identities = 24/78 (30%), Positives = 36/78 (46%), Gaps = 2/78 (2%)
Query: 40 VARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLP-QGLKVKQVEREDAGVYV 98
V G + L C G+P P W++ G +I S R VL L + ++ED +
Sbjct: 4450 VINAGGKIILNCQATGEPQPTITWSRQGHSI-SWDDRVNVLSNNSLYIADAQKEDTSEFE 4508
Query: 99 CKATNGFGSLSVNYTLVV 116
C A N GS+ V ++V
Sbjct: 4509 CVARNLMGSVLVRVPVIV 4526
>gi|222144233 fibroblast growth factor receptor 2 isoform 4
precursor [Homo sapiens]
Length = 709
Score = 103 bits (256), Expect = 5e-22
Identities = 66/235 (28%), Positives = 116/235 (49%), Gaps = 9/235 (3%)
Query: 40 VARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVL-PQGLKVKQVEREDAGVYV 98
VA G ++ ++C ++ + WTKDG +H G + VL + L++K D+G+Y
Sbjct: 51 VAAPGESLEVRCLLKD--AAVISWTKDG--VHLGPNNRTVLIGEYLQIKGATPRDSGLYA 106
Query: 99 CKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRR 158
C A+ S + + + V D IS G + D + + ++ + A P +T KM +R
Sbjct: 107 CTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA-PYWTNTEKMEKR 165
Query: 159 VIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAA---EPRKKKWTLSLKNLRPED 215
+ A P ++V+ +C A G+P P + W+K+ + + + R + W+L ++++ P D
Sbjct: 166 LHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSD 225
Query: 216 SGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKV 270
G YTC V N G+IN TY +DV+ R K + + + G C V
Sbjct: 226 KGNYTCVVENEYGSINHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLIACMV 280
Score = 37.7 bits (86), Expect = 0.025
Identities = 69/311 (22%), Positives = 107/311 (34%), Gaps = 67/311 (21%)
Query: 126 SLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWM 185
SL D++ +E P Q ++P +A P G S+ ++C+ I+W
Sbjct: 26 SLVEDTTLEPEEPPTKYQISQPEV---------YVAAP-GESLEVRCLLKD--AAVISWT 73
Query: 186 KDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRS- 244
KD L P ++ L +K P DSG Y C S + + V+V S
Sbjct: 74 KDGVHLG-PNNRTVLIGEY-LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSG 131
Query: 245 ---------------------KPVLTGTHPVNT---TVDFGGTTSFQCKVRSDVKPVIQW 280
P T T + V T F+C + P ++W
Sbjct: 132 DDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRW 191
Query: 281 LKR-VEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICL 339
LK E+ E R +GG K WS L++ D G Y C+
Sbjct: 192 LKNGKEFKQEHR------IGGYKV----RNQHWS---------LIMESVVPSDKGNYTCV 232
Query: 340 GANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWLC 399
N G + L V+ PG T+ P + I I VF++ +++ +
Sbjct: 233 VENEYGSINHTYHLDVV----APG----REKEITASPDYLEIAIYCIGVFLIACMVVTVI 284
Query: 400 QAQKKPCTPAP 410
+ K T P
Sbjct: 285 LCRMKNTTKKP 295
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 101 bits (252), Expect = 1e-21
Identities = 90/329 (27%), Positives = 122/329 (37%), Gaps = 62/329 (18%)
Query: 43 LGRTVRLQC-PVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKA 101
+G ++C P G P P W KDG + R + L + + DAG YVC
Sbjct: 144 VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVG 203
Query: 102 TNGFGSLSVNYT-LVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVI 160
TN G L VL+ RP F + R +
Sbjct: 204 TNMVGERESEVAELTVLE---------------------------RPSFVK----RPSNL 232
Query: 161 ARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYT 220
A V S KC A G P P + W KDD L P++ + TL ++ + D G YT
Sbjct: 233 AVTVDDSAEFKCEARGDPVPTVRWRKDDGEL--PKSRYEIRDDHTLKIRKVTAGDMGSYT 290
Query: 221 CRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQW 280
C N G A+ + V + S+P P + V G T +FQC+ + +P I W
Sbjct: 291 CVAENMVGKAEASATLTV--QVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFW 348
Query: 281 LKRVEYGAEGRHNSTIDV----GGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMY 336
+ EG N +F V TGD L IT ++ D G Y
Sbjct: 349 RR------EGSQNLLFSYQPPQSSSRFSVSQTGD------------LTITNVQRSDVGYY 390
Query: 337 ICLGANTMGYSFRSAFL---TVLPDPKPP 362
IC N G A+L V+ D PP
Sbjct: 391 ICQTLNVAGSIITKAYLEVTDVIADRPPP 419
Score = 83.2 bits (204), Expect = 5e-16
Identities = 90/330 (27%), Positives = 128/330 (38%), Gaps = 62/330 (18%)
Query: 46 TVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKVKQVEREDAGVYVCKATNG 104
+ +C GDP P W KD + SR+ + LK+++V D G Y C A N
Sbjct: 239 SAEFKCEARGDPVPTVRWRKDDGELPK--SRYEIRDDHTLKIRKVTAGDMGSYTCVAENM 296
Query: 105 FGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPV 164
G + TL V P P F K R +V+A +
Sbjct: 297 VGKAEASATLTVQVGSEP------------------------PHFV--VKPRDQVVA--L 328
Query: 165 GSSVRLKCVASGHPRPDITWMKD-DQALT---RPEAAEPR---KKKWTLSLKNLRPEDSG 217
G +V +C A+G+P+P I W ++ Q L +P + R + L++ N++ D G
Sbjct: 329 GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVG 388
Query: 218 KYTCRVSNRAGAI--NATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVK 275
Y C+ N AG+I A +V + R PV+ PVN TV GT C
Sbjct: 389 YYICQTLNVAGSIITKAYLEVTDVIADRPPPVIR-QGPVNQTVAVDGTFVLSCVATGSPV 447
Query: 276 PVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGM 335
P I W K +G ST D SR L I A+ D G
Sbjct: 448 PTILWRK------DGVLVSTQD---------------SRIKQLENGVLQIRYAKLGDTGR 486
Query: 336 YICLGANTMGYSFRSAFLTVLPDPKPPGPP 365
Y C+ + G + SA++ V P PP
Sbjct: 487 YTCIASTPSGEATWSAYIEVQEFGVPVQPP 516
Score = 77.8 bits (190), Expect = 2e-14
Identities = 98/381 (25%), Positives = 137/381 (35%), Gaps = 90/381 (23%)
Query: 28 PPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSG----WSRFRVLPQG 83
PP++ + V++ G L C EG P P W K G + + S +LP G
Sbjct: 28 PPRIVEHPSDLIVSK-GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86
Query: 84 ----LKV--KQVEREDAGVYVCKATNGFG-SLSVNYTL---VVLDDISPGKESLGPDSSS 133
L++ + R D GVYVC A N G ++S N +L ++ DD P
Sbjct: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQ-----NPSDVM 141
Query: 134 GGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQAL-T 192
+PA + PR GHP P I+W KD L
Sbjct: 142 VAVGEPAVMECQPPR---------------------------GHPEPTISWKKDGSPLDD 174
Query: 193 RPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTH 252
+ E R K L + R D+GKY C +N G + +V + T +
Sbjct: 175 KDERITIRGGK--LMITYTRKSDAGKYVCVGTNMVGERES----EVAELTVLERPSFVKR 228
Query: 253 PVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVW 312
P N V + F+C+ R D P ++W K D G LP
Sbjct: 229 PSNLAVTVDDSAEFKCEARGDPVPTVRWRK--------------DDG-----ELPKSRYE 269
Query: 313 SRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPP---------- 362
R D + L I + D G Y C+ N +G + SA LTV +PP
Sbjct: 270 IRDD----HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQV 325
Query: 363 ---GPPVASSSSATSLPWPVV 380
G V AT P P +
Sbjct: 326 VALGRTVTFQCEATGNPQPAI 346
Score = 76.3 bits (186), Expect = 6e-14
Identities = 60/213 (28%), Positives = 90/213 (42%), Gaps = 34/213 (15%)
Query: 35 VVPR-QVARLGRTVRLQCPVEGDPPPLTMWTKDGR-------TIHSGWSRFRVLPQG-LK 85
V PR QV LGRTV QC G+P P W ++G SRF V G L
Sbjct: 319 VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT 378
Query: 86 VKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWA 145
+ V+R D G Y+C+ N GS+ L V D I+ + ++ P +Q A
Sbjct: 379 ITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV-------IRQGPVNQTVA 431
Query: 146 RPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWT 205
V + L CVA+G P P I W KD ++ ++ + +
Sbjct: 432 ------------------VDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGV 473
Query: 206 LSLKNLRPEDSGKYTCRVSNRAGAINATYKVDV 238
L ++ + D+G+YTC S +G + ++V
Sbjct: 474 LQIRYAKLGDTGRYTCIASTPSGEATWSAYIEV 506
Score = 43.1 bits (100), Expect = 6e-04
Identities = 29/84 (34%), Positives = 40/84 (47%), Gaps = 2/84 (2%)
Query: 24 AARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG 83
A R PP + V + VA G V L C G P P +W KDG + + SR + L G
Sbjct: 414 ADRPPPVIRQGPVNQTVAVDGTFV-LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG 472
Query: 84 -LKVKQVEREDAGVYVCKATNGFG 106
L+++ + D G Y C A+ G
Sbjct: 473 VLQIRYAKLGDTGRYTCIASTPSG 496
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.136 0.429
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,920,218
Number of Sequences: 37866
Number of extensions: 1527725
Number of successful extensions: 16555
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 315
Number of HSP's successfully gapped in prelim test: 384
Number of HSP's that attempted gapping in prelim test: 9122
Number of HSP's gapped (non-prelim): 4686
length of query: 504
length of database: 18,247,518
effective HSP length: 107
effective length of query: 397
effective length of database: 14,195,856
effective search space: 5635754832
effective search space used: 5635754832
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.