Guide to the Human Genome
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Search of human proteins with 51988910

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|51988910 fibroblast growth factor receptor-like 1 precursor
[Homo sapiens]
         (504 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|51988914 fibroblast growth factor receptor-like 1 precursor [...  1048   0.0  
gi|51988910 fibroblast growth factor receptor-like 1 precursor [...  1048   0.0  
gi|51988912 fibroblast growth factor receptor-like 1 precursor [...  1048   0.0  
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs...   176   6e-44
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur...   172   8e-43
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur...   172   8e-43
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu...   171   1e-42
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur...   168   1e-41
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu...   167   2e-41
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu...   167   2e-41
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu...   164   2e-40
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur...   161   1e-39
gi|13186249 fibroblast growth factor receptor 1 isoform 9 precur...   160   3e-39
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu...   160   3e-39
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur...   149   6e-36
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu...   149   8e-36
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu...   147   3e-35
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu...   147   3e-35
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu...   145   1e-34
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu...   142   5e-34
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur...   140   4e-33
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur...   138   1e-32
gi|13186241 fibroblast growth factor receptor 1 isoform 6 precur...   120   2e-27
gi|13186238 fibroblast growth factor receptor 1 isoform 5 precur...   119   8e-27
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]                   107   2e-23
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]                   107   3e-23
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]                   107   3e-23
gi|118572606 hemicentin 1 [Homo sapiens]                              105   1e-22
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu...   103   5e-22
gi|224994173 roundabout 1 isoform d [Homo sapiens]                    101   1e-21

>gi|51988914 fibroblast growth factor receptor-like 1 precursor
           [Homo sapiens]
          Length = 504

 Score = 1048 bits (2709), Expect = 0.0
 Identities = 504/504 (100%), Positives = 504/504 (100%)

Query: 1   MTPSPLLLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPL 60
           MTPSPLLLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPL
Sbjct: 1   MTPSPLLLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPL 60

Query: 61  TMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDI 120
           TMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDI
Sbjct: 61  TMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDI 120

Query: 121 SPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRP 180
           SPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRP
Sbjct: 121 SPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRP 180

Query: 181 DITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQ 240
           DITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQ
Sbjct: 181 DITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQ 240

Query: 241 RTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGG 300
           RTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGG
Sbjct: 241 RTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGG 300

Query: 301 QKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPK 360
           QKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPK
Sbjct: 301 QKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPK 360

Query: 361 PPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWLCQAQKKPCTPAPAPPLPGHRPP 420
           PPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWLCQAQKKPCTPAPAPPLPGHRPP
Sbjct: 361 PPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWLCQAQKKPCTPAPAPPLPGHRPP 420

Query: 421 GTARDRSGDKDLPSLAALSAGPGVGLCEEHGSPAAPQHLLGPGPVAGPKLYPKLYTDIHT 480
           GTARDRSGDKDLPSLAALSAGPGVGLCEEHGSPAAPQHLLGPGPVAGPKLYPKLYTDIHT
Sbjct: 421 GTARDRSGDKDLPSLAALSAGPGVGLCEEHGSPAAPQHLLGPGPVAGPKLYPKLYTDIHT 480

Query: 481 HTHTHSHTHSHVEGKVHQHIHYQC 504
           HTHTHSHTHSHVEGKVHQHIHYQC
Sbjct: 481 HTHTHSHTHSHVEGKVHQHIHYQC 504


>gi|51988910 fibroblast growth factor receptor-like 1 precursor
           [Homo sapiens]
          Length = 504

 Score = 1048 bits (2709), Expect = 0.0
 Identities = 504/504 (100%), Positives = 504/504 (100%)

Query: 1   MTPSPLLLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPL 60
           MTPSPLLLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPL
Sbjct: 1   MTPSPLLLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPL 60

Query: 61  TMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDI 120
           TMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDI
Sbjct: 61  TMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDI 120

Query: 121 SPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRP 180
           SPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRP
Sbjct: 121 SPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRP 180

Query: 181 DITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQ 240
           DITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQ
Sbjct: 181 DITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQ 240

Query: 241 RTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGG 300
           RTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGG
Sbjct: 241 RTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGG 300

Query: 301 QKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPK 360
           QKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPK
Sbjct: 301 QKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPK 360

Query: 361 PPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWLCQAQKKPCTPAPAPPLPGHRPP 420
           PPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWLCQAQKKPCTPAPAPPLPGHRPP
Sbjct: 361 PPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWLCQAQKKPCTPAPAPPLPGHRPP 420

Query: 421 GTARDRSGDKDLPSLAALSAGPGVGLCEEHGSPAAPQHLLGPGPVAGPKLYPKLYTDIHT 480
           GTARDRSGDKDLPSLAALSAGPGVGLCEEHGSPAAPQHLLGPGPVAGPKLYPKLYTDIHT
Sbjct: 421 GTARDRSGDKDLPSLAALSAGPGVGLCEEHGSPAAPQHLLGPGPVAGPKLYPKLYTDIHT 480

Query: 481 HTHTHSHTHSHVEGKVHQHIHYQC 504
           HTHTHSHTHSHVEGKVHQHIHYQC
Sbjct: 481 HTHTHSHTHSHVEGKVHQHIHYQC 504


>gi|51988912 fibroblast growth factor receptor-like 1 precursor
           [Homo sapiens]
          Length = 504

 Score = 1048 bits (2709), Expect = 0.0
 Identities = 504/504 (100%), Positives = 504/504 (100%)

Query: 1   MTPSPLLLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPL 60
           MTPSPLLLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPL
Sbjct: 1   MTPSPLLLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPL 60

Query: 61  TMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDI 120
           TMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDI
Sbjct: 61  TMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDI 120

Query: 121 SPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRP 180
           SPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRP
Sbjct: 121 SPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRP 180

Query: 181 DITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQ 240
           DITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQ
Sbjct: 181 DITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQ 240

Query: 241 RTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGG 300
           RTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGG
Sbjct: 241 RTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGG 300

Query: 301 QKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPK 360
           QKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPK
Sbjct: 301 QKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPK 360

Query: 361 PPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWLCQAQKKPCTPAPAPPLPGHRPP 420
           PPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWLCQAQKKPCTPAPAPPLPGHRPP
Sbjct: 361 PPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWLCQAQKKPCTPAPAPPLPGHRPP 420

Query: 421 GTARDRSGDKDLPSLAALSAGPGVGLCEEHGSPAAPQHLLGPGPVAGPKLYPKLYTDIHT 480
           GTARDRSGDKDLPSLAALSAGPGVGLCEEHGSPAAPQHLLGPGPVAGPKLYPKLYTDIHT
Sbjct: 421 GTARDRSGDKDLPSLAALSAGPGVGLCEEHGSPAAPQHLLGPGPVAGPKLYPKLYTDIHT 480

Query: 481 HTHTHSHTHSHVEGKVHQHIHYQC 504
           HTHTHSHTHSHVEGKVHQHIHYQC
Sbjct: 481 HTHTHSHTHSHVEGKVHQHIHYQC 504


>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
           [Homo sapiens]
          Length = 806

 Score =  176 bits (445), Expect = 6e-44
 Identities = 132/429 (30%), Positives = 202/429 (47%), Gaps = 33/429 (7%)

Query: 44  GRTVRLQCPVEGDPPP-LTMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKAT 102
           G  V L CP  G  P   T+W KDG  +     R  V PQ L+V     ED+G Y C+  
Sbjct: 54  GDAVELSCPPPGGGPMGPTVWVKDGTGLVPS-ERVLVGPQRLQVLNASHEDSGAYSCRQR 112

Query: 103 NGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIAR 162
                L  ++++ V D  S G +  G D +     D  +  W     T+P +M ++++A 
Sbjct: 113 LTQRVLC-HFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYW-----TRPERMDKKLLAV 166

Query: 163 PVGSSVRLKCVASGHPRPDITWMKDDQALT---RPEAAEPRKKKWTLSLKNLRPEDSGKY 219
           P  ++VR +C A+G+P P I+W+K+ +      R    + R ++W+L ++++ P D G Y
Sbjct: 167 PAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNY 226

Query: 220 TCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQ 279
           TC V N+ G+I  TY +DV++R+  +P+L    P N T   G    F CKV SD +P IQ
Sbjct: 227 TCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQ 286

Query: 280 WLKRVEYGAEGRHNSTIDVGGQKFV-VLPTGDVWSRPDGSYLNKLLITRARQDDAGMYIC 338
           WLK VE      + S +   G  +V VL T    +      L  L +     +DAG Y C
Sbjct: 287 WLKHVEV-----NGSKVGPDGTPYVTVLKTAG--ANTTDKELEVLSLHNVTFEDAGEYTC 339

Query: 339 LGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWL 398
           L  N++G+S  SA+L VLP  +     +  +  A S+   ++       +FIL    + L
Sbjct: 340 LAGNSIGFSHHSAWLVVLPAEE----ELVEADEAGSVYAGILSYGVGFFLFILVVAAVTL 395

Query: 399 CQAQKKPCTPAPAP--------PLPGHRPPGTARDRSGDKDLPSLAALSAGPGVGLC--E 448
           C+ +  P     +P        PL       +    S +  L  +A LS+G G  L    
Sbjct: 396 CRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVS 455

Query: 449 EHGSPAAPQ 457
           E   PA P+
Sbjct: 456 ELELPADPK 464



 Score = 33.1 bits (74), Expect = 0.61
 Identities = 34/117 (29%), Positives = 40/117 (34%), Gaps = 30/117 (25%)

Query: 39  QVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--------------- 83
           Q A LG  V   C V  D  P   W K     H   +  +V P G               
Sbjct: 263 QTAVLGSDVEFHCKVYSDAQPHIQWLK-----HVEVNGSKVGPDGTPYVTVLKTAGANTT 317

Query: 84  ------LKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSG 134
                 L +  V  EDAG Y C A N  G    +  LVVL    P +E L     +G
Sbjct: 318 DKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVL----PAEEELVEADEAG 370


>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
           [Homo sapiens]
          Length = 802

 Score =  172 bits (435), Expect = 8e-43
 Identities = 125/385 (32%), Positives = 185/385 (48%), Gaps = 32/385 (8%)

Query: 6   LLLLLLPPLLLGAFPPAAAARGP------PKMADKVVPRQ---VARLGRTVRLQCPVEGD 56
           LLL LL  LL    PP  +          P +A  +  ++      LG+ VRL C   G 
Sbjct: 3   LLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCC---GR 59

Query: 57  PPPLTMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSV--NYTL 114
                 W K+G  +     R R     L++     EDAG Y+C A    GS+ V  N TL
Sbjct: 60  AERGGHWYKEGSRLAPA-GRVRGWRGRLEIASFLPEDAGRYLCLAR---GSMIVLQNLTL 115

Query: 115 VVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVA 174
           +  D ++   +   P S        +  Q A P +T P +M +++ A P G++V+ +C A
Sbjct: 116 ITGDSLTSSNDDEDPKSHRDPSNRHSYPQQA-PYWTHPQRMEKKLHAVPAGNTVKFRCPA 174

Query: 175 SGHPRPDITWMKDDQAL---TRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAIN 231
           +G+P P I W+KD QA     R      R + W+L ++++ P D G YTC V N  G+I 
Sbjct: 175 AGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIR 234

Query: 232 ATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGR 291
             Y +DV++R+  +P+L    P NTT   G      CKV SD +P IQWLK +       
Sbjct: 235 YNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVI----- 289

Query: 292 HNSTIDVGGQKFV-VLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRS 350
           + S+    G  +V VL T D+    + S +  L +     +DAG Y CL  N++G S++S
Sbjct: 290 NGSSFGADGFPYVQVLKTADI----NSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQS 345

Query: 351 AFLTVLPDPKPPGPPVASSSSATSL 375
           A+LTVLP+  P     A  +  T +
Sbjct: 346 AWLTVLPEEDPTWTAAAPEARYTDI 370


>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
           [Homo sapiens]
          Length = 802

 Score =  172 bits (435), Expect = 8e-43
 Identities = 125/385 (32%), Positives = 185/385 (48%), Gaps = 32/385 (8%)

Query: 6   LLLLLLPPLLLGAFPPAAAARGP------PKMADKVVPRQ---VARLGRTVRLQCPVEGD 56
           LLL LL  LL    PP  +          P +A  +  ++      LG+ VRL C   G 
Sbjct: 3   LLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCC---GR 59

Query: 57  PPPLTMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSV--NYTL 114
                 W K+G  +     R R     L++     EDAG Y+C A    GS+ V  N TL
Sbjct: 60  AERGGHWYKEGSRLAPA-GRVRGWRGRLEIASFLPEDAGRYLCLAR---GSMIVLQNLTL 115

Query: 115 VVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVA 174
           +  D ++   +   P S        +  Q A P +T P +M +++ A P G++V+ +C A
Sbjct: 116 ITGDSLTSSNDDEDPKSHRDPSNRHSYPQQA-PYWTHPQRMEKKLHAVPAGNTVKFRCPA 174

Query: 175 SGHPRPDITWMKDDQAL---TRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAIN 231
           +G+P P I W+KD QA     R      R + W+L ++++ P D G YTC V N  G+I 
Sbjct: 175 AGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIR 234

Query: 232 ATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGR 291
             Y +DV++R+  +P+L    P NTT   G      CKV SD +P IQWLK +       
Sbjct: 235 YNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVI----- 289

Query: 292 HNSTIDVGGQKFV-VLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRS 350
           + S+    G  +V VL T D+    + S +  L +     +DAG Y CL  N++G S++S
Sbjct: 290 NGSSFGADGFPYVQVLKTADI----NSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQS 345

Query: 351 AFLTVLPDPKPPGPPVASSSSATSL 375
           A+LTVLP+  P     A  +  T +
Sbjct: 346 AWLTVLPEEDPTWTAAAPEARYTDI 370


>gi|221316639 fibroblast growth factor receptor 2 isoform 1
           precursor [Homo sapiens]
          Length = 821

 Score =  171 bits (434), Expect = 1e-42
 Identities = 115/376 (30%), Positives = 187/376 (49%), Gaps = 24/376 (6%)

Query: 40  VARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVL-PQGLKVKQVEREDAGVYV 98
           VA  G ++ ++C ++     +  WTKDG  +H G +   VL  + L++K     D+G+Y 
Sbjct: 51  VAAPGESLEVRCLLKD--AAVISWTKDG--VHLGPNNRTVLIGEYLQIKGATPRDSGLYA 106

Query: 99  CKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRR 158
           C A+    S +  + + V D IS G +    D +     + ++ + A P +T   KM +R
Sbjct: 107 CTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA-PYWTNTEKMEKR 165

Query: 159 VIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAA---EPRKKKWTLSLKNLRPED 215
           + A P  ++V+ +C A G+P P + W+K+ +   +       + R + W+L ++++ P D
Sbjct: 166 LHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSD 225

Query: 216 SGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVK 275
            G YTC V N  G+IN TY +DV++R+  +P+L    P N +   GG   F CKV SD +
Sbjct: 226 KGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQ 285

Query: 276 PVIQWLKRVEYGAEGRHNSTIDVGGQKFV-VLPTGDVWSRPDGSYLNKLLITRARQDDAG 334
           P IQW+K VE     ++ S     G  ++ VL    V        +  L I     +DAG
Sbjct: 286 PHIQWIKHVE-----KNGSKYGPDGLPYLKVLKAAGV--NTTDKEIEVLYIRNVTFEDAG 338

Query: 335 MYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIPAGAVFILGTL 394
            Y CL  N++G SF SA+LTVLP P             T+ P  + I I    VF++  +
Sbjct: 339 EYTCLAGNSIGISFHSAWLTVLPAP-------GREKEITASPDYLEIAIYCIGVFLIACM 391

Query: 395 LLWLCQAQKKPCTPAP 410
           ++ +   + K  T  P
Sbjct: 392 VVTVILCRMKNTTKKP 407


>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
           [Homo sapiens]
          Length = 762

 Score =  168 bits (425), Expect = 1e-41
 Identities = 122/367 (33%), Positives = 179/367 (48%), Gaps = 32/367 (8%)

Query: 6   LLLLLLPPLLLGAFPPAAAARGP------PKMADKVVPRQ---VARLGRTVRLQCPVEGD 56
           LLL LL  LL    PP  +          P +A  +  ++      LG+ VRL C   G 
Sbjct: 3   LLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCC---GR 59

Query: 57  PPPLTMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSV--NYTL 114
                 W K+G  +     R R     L++     EDAG Y+C A    GS+ V  N TL
Sbjct: 60  AERGGHWYKEGSRLAPA-GRVRGWRGRLEIASFLPEDAGRYLCLAR---GSMIVLQNLTL 115

Query: 115 VVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVA 174
           +  D ++   +   P S        +  Q A P +T P +M +++ A P G++V+ +C A
Sbjct: 116 ITGDSLTSSNDDEDPKSHRDPSNRHSYPQQA-PYWTHPQRMEKKLHAVPAGNTVKFRCPA 174

Query: 175 SGHPRPDITWMKDDQAL---TRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAIN 231
           +G+P P I W+KD QA     R      R + W+L ++++ P D G YTC V N  G+I 
Sbjct: 175 AGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIR 234

Query: 232 ATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGR 291
             Y +DV++R+  +P+L    P NTT   G      CKV SD +P IQWLK +       
Sbjct: 235 YNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVI----- 289

Query: 292 HNSTIDVGGQKFV-VLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRS 350
           + S+    G  +V VL T D+    + S +  L +     +DAG Y CL  N++G S++S
Sbjct: 290 NGSSFGADGFPYVQVLKTADI----NSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQS 345

Query: 351 AFLTVLP 357
           A+LTVLP
Sbjct: 346 AWLTVLP 352



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 64/225 (28%), Positives = 84/225 (37%), Gaps = 47/225 (20%)

Query: 44  GRTVRLQCPVEGDPPPLTMWTKDGRTIHS----GWSRFRVLPQGLKVKQVEREDAGVYVC 99
           G TV+ +CP  G+P P   W KDG+  H     G  R R     L ++ V   D G Y C
Sbjct: 165 GNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTC 224

Query: 100 KATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRV 159
              N  GS+  NY L VL+  SP +  L               Q   P  T         
Sbjct: 225 LVENAVGSIRYNYLLDVLER-SPHRPIL---------------QAGLPANT--------- 259

Query: 160 IARPVGSSVRLKCVASGHPRPDITWMKDD---------------QALTRPEAAEPRKKKW 204
               VGS V L C      +P I W+K                 Q L   +      +  
Sbjct: 260 -TAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVE-- 316

Query: 205 TLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLT 249
            L L+N+  ED+G+YTC   N  G    +  + V+  T   P LT
Sbjct: 317 VLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPGTGRIPHLT 361


>gi|222144231 fibroblast growth factor receptor 2 isoform 3
           precursor [Homo sapiens]
          Length = 769

 Score =  167 bits (424), Expect = 2e-41
 Identities = 113/376 (30%), Positives = 190/376 (50%), Gaps = 23/376 (6%)

Query: 40  VARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVL-PQGLKVKQVEREDAGVYV 98
           VA  G ++ ++C ++     +  WTKDG  +H G +   VL  + L++K     D+G+Y 
Sbjct: 51  VAAPGESLEVRCLLKD--AAVISWTKDG--VHLGPNNRTVLIGEYLQIKGATPRDSGLYA 106

Query: 99  CKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRR 158
           C A+    S +  + + V D IS G +    D +     + ++ + A P +T   KM +R
Sbjct: 107 CTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA-PYWTNTEKMEKR 165

Query: 159 VIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAA---EPRKKKWTLSLKNLRPED 215
           + A P  ++V+ +C A G+P P + W+K+ +   +       + R + W+L ++++ P D
Sbjct: 166 LHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSD 225

Query: 216 SGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVK 275
            G YTC V N  G+IN TY +DV++R+  +P+L    P N +   GG   F CKV SD +
Sbjct: 226 KGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQ 285

Query: 276 PVIQWLKRVEYGAEGRHNSTIDVGGQKFV-VLPTGDVWSRPDGSYLNKLLITRARQDDAG 334
           P IQW+K VE     ++ S     G  ++ VL    +    + S    L +    + DAG
Sbjct: 286 PHIQWIKHVE-----KNGSKYGPDGLPYLKVLKHSGI----NSSNAEVLALFNVTEADAG 336

Query: 335 MYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIPAGAVFILGTL 394
            YIC  +N +G + +SA+LTVLP  + PG         T+ P  + I I    VF++  +
Sbjct: 337 EYICKVSNYIGQANQSAWLTVLPKQQAPG----REKEITASPDYLEIAIYCIGVFLIACM 392

Query: 395 LLWLCQAQKKPCTPAP 410
           ++ +   + K  T  P
Sbjct: 393 VVTVILCRMKNTTKKP 408


>gi|221316638 fibroblast growth factor receptor 2 isoform 2
           precursor [Homo sapiens]
          Length = 822

 Score =  167 bits (424), Expect = 2e-41
 Identities = 113/376 (30%), Positives = 190/376 (50%), Gaps = 23/376 (6%)

Query: 40  VARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVL-PQGLKVKQVEREDAGVYV 98
           VA  G ++ ++C ++     +  WTKDG  +H G +   VL  + L++K     D+G+Y 
Sbjct: 51  VAAPGESLEVRCLLKD--AAVISWTKDG--VHLGPNNRTVLIGEYLQIKGATPRDSGLYA 106

Query: 99  CKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRR 158
           C A+    S +  + + V D IS G +    D +     + ++ + A P +T   KM +R
Sbjct: 107 CTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA-PYWTNTEKMEKR 165

Query: 159 VIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAA---EPRKKKWTLSLKNLRPED 215
           + A P  ++V+ +C A G+P P + W+K+ +   +       + R + W+L ++++ P D
Sbjct: 166 LHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSD 225

Query: 216 SGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVK 275
            G YTC V N  G+IN TY +DV++R+  +P+L    P N +   GG   F CKV SD +
Sbjct: 226 KGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQ 285

Query: 276 PVIQWLKRVEYGAEGRHNSTIDVGGQKFV-VLPTGDVWSRPDGSYLNKLLITRARQDDAG 334
           P IQW+K VE     ++ S     G  ++ VL    +    + S    L +    + DAG
Sbjct: 286 PHIQWIKHVE-----KNGSKYGPDGLPYLKVLKHSGI----NSSNAEVLALFNVTEADAG 336

Query: 335 MYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIPAGAVFILGTL 394
            YIC  +N +G + +SA+LTVLP  + PG         T+ P  + I I    VF++  +
Sbjct: 337 EYICKVSNYIGQANQSAWLTVLPKQQAPG----REKEITASPDYLEIAIYCIGVFLIACM 392

Query: 395 LLWLCQAQKKPCTPAP 410
           ++ +   + K  T  P
Sbjct: 393 VVTVILCRMKNTTKKP 408


>gi|254028242 fibroblast growth factor receptor 3 isoform 3
           precursor [Homo sapiens]
          Length = 808

 Score =  164 bits (415), Expect = 2e-40
 Identities = 123/428 (28%), Positives = 197/428 (46%), Gaps = 29/428 (6%)

Query: 44  GRTVRLQCPVEGDPPP-LTMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKAT 102
           G  V L CP  G  P   T+W KDG  +     R  V PQ L+V     ED+G Y C+  
Sbjct: 54  GDAVELSCPPPGGGPMGPTVWVKDGTGLVPS-ERVLVGPQRLQVLNASHEDSGAYSCRQR 112

Query: 103 NGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIAR 162
                L  ++++ V D  S G +  G D +     D  +  W     T+P +M ++++A 
Sbjct: 113 LTQRVLC-HFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYW-----TRPERMDKKLLAV 166

Query: 163 PVGSSVRLKCVASGHPRPDITWMKDDQALT---RPEAAEPRKKKWTLSLKNLRPEDSGKY 219
           P  ++VR +C A+G+P P I+W+K+ +      R    + R ++W+L ++++ P D G Y
Sbjct: 167 PAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNY 226

Query: 220 TCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQ 279
           TC V N+ G+I  TY +DV++R+  +P+L    P N T   G    F CKV SD +P IQ
Sbjct: 227 TCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQ 286

Query: 280 WLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICL 339
           WLK VE      + S +   G  +V +     W         +L +    + D G Y+C 
Sbjct: 287 WLKHVEV-----NGSKVGPDGTPYVTVLKS--WISESVEADVRLRLANVSERDGGEYLCR 339

Query: 340 GANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWLC 399
             N +G + ++ +L+V   P+     +  +  A S+   ++       +FIL    + LC
Sbjct: 340 ATNFIGVAEKAFWLSV-HGPRAAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLC 398

Query: 400 QAQKKPCTPAPAP--------PLPGHRPPGTARDRSGDKDLPSLAALSAGPGVGLC--EE 449
           + +  P     +P        PL       +    S +  L  +A LS+G G  L    E
Sbjct: 399 RLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSE 458

Query: 450 HGSPAAPQ 457
              PA P+
Sbjct: 459 LELPADPK 466



 Score = 34.3 bits (77), Expect = 0.27
 Identities = 26/83 (31%), Positives = 31/83 (37%), Gaps = 15/83 (18%)

Query: 39  QVARLGRTVRLQCPVEGDPPPLTMWTK-----------DGR---TIHSGW-SRFRVLPQG 83
           Q A LG  V   C V  D  P   W K           DG    T+   W S        
Sbjct: 263 QTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVR 322

Query: 84  LKVKQVEREDAGVYVCKATNGFG 106
           L++  V   D G Y+C+ATN  G
Sbjct: 323 LRLANVSERDGGEYLCRATNFIG 345


>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
           [Homo sapiens]
          Length = 820

 Score =  161 bits (408), Expect = 1e-39
 Identities = 106/343 (30%), Positives = 163/343 (47%), Gaps = 17/343 (4%)

Query: 21  PAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVL 80
           P    +  P  A   V   +   G  ++L+C +  D   +  W +DG  +    +R R+ 
Sbjct: 25  PTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSIN-WLRDGVQLAES-NRTRIT 82

Query: 81  PQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQE--- 137
            + ++V+     D+G+Y C  ++  GS    Y  V + D  P  E    D  S  +E   
Sbjct: 83  GEEVEVQDSVPADSGLYACVTSSPSGS-DTTYFSVNVSDALPSSEDDDDDDDSSSEEKET 141

Query: 138 DPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALT---RP 194
           D        P +T P KM +++ A P   +V+ KC +SG P P + W+K+ +      R 
Sbjct: 142 DNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRI 201

Query: 195 EAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPV 254
              + R   W++ + ++ P D G YTC V N  G+IN TY++DV++R+  +P+L    P 
Sbjct: 202 GGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPA 261

Query: 255 NTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFV-VLPTGDVWS 313
           N TV  G    F CKV SD +P IQWLK +E      + S I      +V +L T  V  
Sbjct: 262 NKTVALGSNVEFMCKVYSDPQPHIQWLKHIEV-----NGSKIGPDNLPYVQILKTAGV-- 314

Query: 314 RPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVL 356
                 +  L +     +DAG Y CL  N++G S  SA+LTVL
Sbjct: 315 NTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL 357



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 65/273 (23%), Positives = 100/273 (36%), Gaps = 49/273 (17%)

Query: 20  PPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHS----GWS 75
           P A     P KM  K+         +TV+ +CP  G P P   W K+G+        G  
Sbjct: 148 PVAPYWTSPEKMEKKL---HAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGY 204

Query: 76  RFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGG 135
           + R     + +  V   D G Y C   N +GS++  Y L V++  SP +  L        
Sbjct: 205 KVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVER-SPHRPIL-------- 255

Query: 136 QEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDD------- 188
                          Q      + +A  +GS+V   C     P+P I W+K         
Sbjct: 256 ---------------QAGLPANKTVA--LGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI 298

Query: 189 --------QALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQ 240
                   Q L         K+   L L+N+  ED+G+YTC   N  G  + +  + V++
Sbjct: 299 GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE 358

Query: 241 RTRSKP-VLTGTHPVNTTVDFGGTTSFQCKVRS 272
               +P V+T    +   +   G     C V S
Sbjct: 359 ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGS 391


>gi|13186249 fibroblast growth factor receptor 1 isoform 9 precursor
           [Homo sapiens]
          Length = 785

 Score =  160 bits (404), Expect = 3e-39
 Identities = 103/344 (29%), Positives = 170/344 (49%), Gaps = 17/344 (4%)

Query: 21  PAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVL 80
           P    +  P  A   V   +   G  ++L+C +  D   +  W +DG  +    +R R+ 
Sbjct: 25  PTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSIN-WLRDGVQLAES-NRTRIT 82

Query: 81  PQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPA 140
            + ++V+     D+G+Y C  ++  GS +  +++ V D +   ++    D SS  +++  
Sbjct: 83  GEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETD 142

Query: 141 SQQWAR----PRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALT---R 193
           + +  R    P +T P KM +++ A P   +V+ KC +SG P P + W+K+ +      R
Sbjct: 143 NTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHR 202

Query: 194 PEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHP 253
               + R   W++ + ++ P D G YTC V N  G+IN TY++DV++R+  +P+L    P
Sbjct: 203 IGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLP 262

Query: 254 VNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFV-VLPTGDVW 312
            N TV  G    F CKV SD +P IQWLK +E      + S I      +V +L T  V 
Sbjct: 263 ANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEV-----NGSKIGPDNLPYVQILKTAGV- 316

Query: 313 SRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVL 356
                  +  L +     +DAG Y CL  N++G S  SA+LTVL
Sbjct: 317 -NTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL 359



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 65/273 (23%), Positives = 100/273 (36%), Gaps = 49/273 (17%)

Query: 20  PPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHS----GWS 75
           P A     P KM  K+         +TV+ +CP  G P P   W K+G+        G  
Sbjct: 150 PVAPYWTSPEKMEKKL---HAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGY 206

Query: 76  RFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGG 135
           + R     + +  V   D G Y C   N +GS++  Y L V++  SP +  L        
Sbjct: 207 KVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVER-SPHRPIL-------- 257

Query: 136 QEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDD------- 188
                          Q      + +A  +GS+V   C     P+P I W+K         
Sbjct: 258 ---------------QAGLPANKTVA--LGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI 300

Query: 189 --------QALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQ 240
                   Q L         K+   L L+N+  ED+G+YTC   N  G  + +  + V++
Sbjct: 301 GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE 360

Query: 241 RTRSKP-VLTGTHPVNTTVDFGGTTSFQCKVRS 272
               +P V+T    +   +   G     C V S
Sbjct: 361 ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGS 393


>gi|105990522 fibroblast growth factor receptor 1 isoform 1
           precursor [Homo sapiens]
          Length = 822

 Score =  160 bits (404), Expect = 3e-39
 Identities = 103/344 (29%), Positives = 170/344 (49%), Gaps = 17/344 (4%)

Query: 21  PAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVL 80
           P    +  P  A   V   +   G  ++L+C +  D   +  W +DG  +    +R R+ 
Sbjct: 25  PTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSIN-WLRDGVQLAES-NRTRIT 82

Query: 81  PQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPA 140
            + ++V+     D+G+Y C  ++  GS +  +++ V D +   ++    D SS  +++  
Sbjct: 83  GEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETD 142

Query: 141 SQQWAR----PRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALT---R 193
           + +  R    P +T P KM +++ A P   +V+ KC +SG P P + W+K+ +      R
Sbjct: 143 NTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHR 202

Query: 194 PEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHP 253
               + R   W++ + ++ P D G YTC V N  G+IN TY++DV++R+  +P+L    P
Sbjct: 203 IGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLP 262

Query: 254 VNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFV-VLPTGDVW 312
            N TV  G    F CKV SD +P IQWLK +E      + S I      +V +L T  V 
Sbjct: 263 ANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEV-----NGSKIGPDNLPYVQILKTAGV- 316

Query: 313 SRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVL 356
                  +  L +     +DAG Y CL  N++G S  SA+LTVL
Sbjct: 317 -NTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL 359



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 65/273 (23%), Positives = 100/273 (36%), Gaps = 49/273 (17%)

Query: 20  PPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHS----GWS 75
           P A     P KM  K+         +TV+ +CP  G P P   W K+G+        G  
Sbjct: 150 PVAPYWTSPEKMEKKL---HAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGY 206

Query: 76  RFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGG 135
           + R     + +  V   D G Y C   N +GS++  Y L V++  SP +  L        
Sbjct: 207 KVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVER-SPHRPIL-------- 257

Query: 136 QEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDD------- 188
                          Q      + +A  +GS+V   C     P+P I W+K         
Sbjct: 258 ---------------QAGLPANKTVA--LGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI 300

Query: 189 --------QALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQ 240
                   Q L         K+   L L+N+  ED+G+YTC   N  G  + +  + V++
Sbjct: 301 GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE 360

Query: 241 RTRSKP-VLTGTHPVNTTVDFGGTTSFQCKVRS 272
               +P V+T    +   +   G     C V S
Sbjct: 361 ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGS 393


>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
           [Homo sapiens]
          Length = 694

 Score =  149 bits (376), Expect = 6e-36
 Identities = 86/246 (34%), Positives = 130/246 (52%), Gaps = 11/246 (4%)

Query: 44  GRTVRLQCPVEGDPPP-LTMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKAT 102
           G  V L CP  G  P   T+W KDG  +     R  V PQ L+V     ED+G Y C+  
Sbjct: 54  GDAVELSCPPPGGGPMGPTVWVKDGTGLVPS-ERVLVGPQRLQVLNASHEDSGAYSCRQR 112

Query: 103 NGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIAR 162
                L  ++++ V D  S G +  G D +     D  +  W     T+P +M ++++A 
Sbjct: 113 LTQRVLC-HFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYW-----TRPERMDKKLLAV 166

Query: 163 PVGSSVRLKCVASGHPRPDITWMKDDQALT---RPEAAEPRKKKWTLSLKNLRPEDSGKY 219
           P  ++VR +C A+G+P P I+W+K+ +      R    + R ++W+L ++++ P D G Y
Sbjct: 167 PAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNY 226

Query: 220 TCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQ 279
           TC V N+ G+I  TY +DV++R+  +P+L    P N T   G    F CKV SD +P IQ
Sbjct: 227 TCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQ 286

Query: 280 WLKRVE 285
           WLK VE
Sbjct: 287 WLKHVE 292


>gi|222144235 fibroblast growth factor receptor 2 isoform 5
           precursor [Homo sapiens]
          Length = 707

 Score =  149 bits (375), Expect = 8e-36
 Identities = 97/308 (31%), Positives = 152/308 (49%), Gaps = 19/308 (6%)

Query: 107 SLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGS 166
           SL  + TL   D IS G +    D +     + ++ + A P +T   KM +R+ A P  +
Sbjct: 26  SLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSNNKRA-PYWTNTEKMEKRLHAVPAAN 84

Query: 167 SVRLKCVASGHPRPDITWMKDDQALTRPEAA---EPRKKKWTLSLKNLRPEDSGKYTCRV 223
           +V+ +C A G+P P + W+K+ +   +       + R + W+L ++++ P D G YTC V
Sbjct: 85  TVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVV 144

Query: 224 SNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKR 283
            N  G+IN TY +DV++R+  +P+L    P N +   GG   F CKV SD +P IQW+K 
Sbjct: 145 ENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKH 204

Query: 284 VEYGAEGRHNSTIDVGGQKFV-VLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGAN 342
           VE     ++ S     G  ++ VL    V        +  L I     +DAG Y CL  N
Sbjct: 205 VE-----KNGSKYGPDGLPYLKVLKAAGV--NTTDKEIEVLYIRNVTFEDAGEYTCLAGN 257

Query: 343 TMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWLCQAQ 402
           ++G SF SA+LTVLP P             T+ P  + I I    VF++  +++ +   +
Sbjct: 258 SIGISFHSAWLTVLPAP-------GREKEITASPDYLEIAIYCIGVFLIACMVVTVILCR 310

Query: 403 KKPCTPAP 410
            K  T  P
Sbjct: 311 MKNTTKKP 318



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 50/202 (24%), Positives = 73/202 (36%), Gaps = 45/202 (22%)

Query: 46  TVRLQCPVEGDPPPLTMWTKDGRTIHS----GWSRFRVLPQGLKVKQVEREDAGVYVCKA 101
           TV+ +CP  G+P P   W K+G+        G  + R     L ++ V   D G Y C  
Sbjct: 85  TVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVV 144

Query: 102 TNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIA 161
            N +GS++  Y L V++  SP +  L       G    AS                    
Sbjct: 145 ENEYGSINHTYHLDVVER-SPHRPIL-----QAGLPANAS-------------------- 178

Query: 162 RPVGSSVRLKCVASGHPRPDITWMKDDQ---------------ALTRPEAAEPRKKKWTL 206
             VG  V   C      +P I W+K  +                L         K+   L
Sbjct: 179 TVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVL 238

Query: 207 SLKNLRPEDSGKYTCRVSNRAG 228
            ++N+  ED+G+YTC   N  G
Sbjct: 239 YIRNVTFEDAGEYTCLAGNSIG 260



 Score = 29.3 bits (64), Expect = 8.8
 Identities = 29/99 (29%), Positives = 36/99 (36%), Gaps = 18/99 (18%)

Query: 43  LGRTVRLQCPVEGDPPPLTMWTKDGRTIHS-----GWSRFRVLPQG-----------LKV 86
           +G  V   C V  D  P   W K      S     G    +VL              L +
Sbjct: 181 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 240

Query: 87  KQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKE 125
           + V  EDAG Y C A N  G    +  L VL   +PG+E
Sbjct: 241 RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLP--APGRE 277


>gi|222144241 fibroblast growth factor receptor 2 isoform 8
           precursor [Homo sapiens]
          Length = 704

 Score =  147 bits (370), Expect = 3e-35
 Identities = 89/278 (32%), Positives = 138/278 (49%), Gaps = 18/278 (6%)

Query: 137 EDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEA 196
           ED   +    P +T   KM +R+ A P  ++V+ +C A G+P P + W+K+ +   +   
Sbjct: 29  EDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR 88

Query: 197 A---EPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHP 253
               + R + W+L ++++ P D G YTC V N  G+IN TY +DV++R+  +P+L    P
Sbjct: 89  IGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLP 148

Query: 254 VNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFV-VLPTGDVW 312
            N +   GG   F CKV SD +P IQW+K VE     ++ S     G  ++ VL    V 
Sbjct: 149 ANASTVVGGDVEFVCKVYSDAQPHIQWIKHVE-----KNGSKYGPDGLPYLKVLKAAGV- 202

Query: 313 SRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSA 372
                  +  L I     +DAG Y CL  N++G SF SA+LTVLP P             
Sbjct: 203 -NTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAP-------GREKEI 254

Query: 373 TSLPWPVVIGIPAGAVFILGTLLLWLCQAQKKPCTPAP 410
           T+ P  + I I    VF++  +++ +   + K  T  P
Sbjct: 255 TASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKP 292



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 50/202 (24%), Positives = 73/202 (36%), Gaps = 45/202 (22%)

Query: 46  TVRLQCPVEGDPPPLTMWTKDGRTIHS----GWSRFRVLPQGLKVKQVEREDAGVYVCKA 101
           TV+ +CP  G+P P   W K+G+        G  + R     L ++ V   D G Y C  
Sbjct: 59  TVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVV 118

Query: 102 TNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIA 161
            N +GS++  Y L V++  SP +  L       G    AS                    
Sbjct: 119 ENEYGSINHTYHLDVVER-SPHRPIL-----QAGLPANAS-------------------- 152

Query: 162 RPVGSSVRLKCVASGHPRPDITWMKDDQ---------------ALTRPEAAEPRKKKWTL 206
             VG  V   C      +P I W+K  +                L         K+   L
Sbjct: 153 TVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVL 212

Query: 207 SLKNLRPEDSGKYTCRVSNRAG 228
            ++N+  ED+G+YTC   N  G
Sbjct: 213 YIRNVTFEDAGEYTCLAGNSIG 234



 Score = 29.3 bits (64), Expect = 8.8
 Identities = 29/99 (29%), Positives = 36/99 (36%), Gaps = 18/99 (18%)

Query: 43  LGRTVRLQCPVEGDPPPLTMWTKDGRTIHS-----GWSRFRVLPQG-----------LKV 86
           +G  V   C V  D  P   W K      S     G    +VL              L +
Sbjct: 155 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 214

Query: 87  KQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKE 125
           + V  EDAG Y C A N  G    +  L VL   +PG+E
Sbjct: 215 RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLP--APGRE 251


>gi|222144237 fibroblast growth factor receptor 2 isoform 6
           precursor [Homo sapiens]
          Length = 706

 Score =  147 bits (370), Expect = 3e-35
 Identities = 89/278 (32%), Positives = 138/278 (49%), Gaps = 18/278 (6%)

Query: 137 EDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEA 196
           ED   +    P +T   KM +R+ A P  ++V+ +C A G+P P + W+K+ +   +   
Sbjct: 29  EDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR 88

Query: 197 A---EPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHP 253
               + R + W+L ++++ P D G YTC V N  G+IN TY +DV++R+  +P+L    P
Sbjct: 89  IGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLP 148

Query: 254 VNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFV-VLPTGDVW 312
            N +   GG   F CKV SD +P IQW+K VE     ++ S     G  ++ VL    V 
Sbjct: 149 ANASTVVGGDVEFVCKVYSDAQPHIQWIKHVE-----KNGSKYGPDGLPYLKVLKAAGV- 202

Query: 313 SRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSA 372
                  +  L I     +DAG Y CL  N++G SF SA+LTVLP P             
Sbjct: 203 -NTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAP-------GREKEI 254

Query: 373 TSLPWPVVIGIPAGAVFILGTLLLWLCQAQKKPCTPAP 410
           T+ P  + I I    VF++  +++ +   + K  T  P
Sbjct: 255 TASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKP 292



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 50/202 (24%), Positives = 73/202 (36%), Gaps = 45/202 (22%)

Query: 46  TVRLQCPVEGDPPPLTMWTKDGRTIHS----GWSRFRVLPQGLKVKQVEREDAGVYVCKA 101
           TV+ +CP  G+P P   W K+G+        G  + R     L ++ V   D G Y C  
Sbjct: 59  TVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVV 118

Query: 102 TNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIA 161
            N +GS++  Y L V++  SP +  L       G    AS                    
Sbjct: 119 ENEYGSINHTYHLDVVER-SPHRPIL-----QAGLPANAS-------------------- 152

Query: 162 RPVGSSVRLKCVASGHPRPDITWMKDDQ---------------ALTRPEAAEPRKKKWTL 206
             VG  V   C      +P I W+K  +                L         K+   L
Sbjct: 153 TVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVL 212

Query: 207 SLKNLRPEDSGKYTCRVSNRAG 228
            ++N+  ED+G+YTC   N  G
Sbjct: 213 YIRNVTFEDAGEYTCLAGNSIG 234



 Score = 29.3 bits (64), Expect = 8.8
 Identities = 29/99 (29%), Positives = 36/99 (36%), Gaps = 18/99 (18%)

Query: 43  LGRTVRLQCPVEGDPPPLTMWTKDGRTIHS-----GWSRFRVLPQG-----------LKV 86
           +G  V   C V  D  P   W K      S     G    +VL              L +
Sbjct: 155 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 214

Query: 87  KQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKE 125
           + V  EDAG Y C A N  G    +  L VL   +PG+E
Sbjct: 215 RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLP--APGRE 251


>gi|222144244 fibroblast growth factor receptor 2 isoform 9
           precursor [Homo sapiens]
          Length = 680

 Score =  145 bits (365), Expect = 1e-34
 Identities = 95/308 (30%), Positives = 155/308 (50%), Gaps = 18/308 (5%)

Query: 107 SLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGS 166
           SL  + TL   D IS G +    D +     + ++ + A P +T   KM +R+ A P  +
Sbjct: 26  SLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSNNKRA-PYWTNTEKMEKRLHAVPAAN 84

Query: 167 SVRLKCVASGHPRPDITWMKDDQALTRPEAA---EPRKKKWTLSLKNLRPEDSGKYTCRV 223
           +V+ +C A G+P P + W+K+ +   +       + R + W+L ++++ P D G YTC V
Sbjct: 85  TVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVV 144

Query: 224 SNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKR 283
            N  G+IN TY +DV++R+  +P+L    P N +   GG   F CKV SD +P IQW+K 
Sbjct: 145 ENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKH 204

Query: 284 VEYGAEGRHNSTIDVGGQKFV-VLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGAN 342
           VE     ++ S     G  ++ VL    +    + S    L +    + DAG YIC  +N
Sbjct: 205 VE-----KNGSKYGPDGLPYLKVLKHSGI----NSSNAEVLALFNVTEADAGEYICKVSN 255

Query: 343 TMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWLCQAQ 402
            +G + +SA+LTVLP  + PG         T+ P  + I I    VF++  +++ +   +
Sbjct: 256 YIGQANQSAWLTVLPKQQAPG----REKEITASPDYLEIAIYCIGVFLIACMVVTVILCR 311

Query: 403 KKPCTPAP 410
            K  T  P
Sbjct: 312 MKNTTKKP 319



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 53/216 (24%), Positives = 83/216 (38%), Gaps = 43/216 (19%)

Query: 46  TVRLQCPVEGDPPPLTMWTKDGRTIHS----GWSRFRVLPQGLKVKQVEREDAGVYVCKA 101
           TV+ +CP  G+P P   W K+G+        G  + R     L ++ V   D G Y C  
Sbjct: 85  TVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVV 144

Query: 102 TNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIA 161
            N +GS++  Y L V++  SP +  L       G    AS                    
Sbjct: 145 ENEYGSINHTYHLDVVER-SPHRPIL-----QAGLPANAS-------------------- 178

Query: 162 RPVGSSVRLKCVASGHPRPDITWMK---DDQALTRPEAAEPRK----------KKWTLSL 208
             VG  V   C      +P I W+K    + +   P+     K              L+L
Sbjct: 179 TVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLAL 238

Query: 209 KNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRS 244
            N+   D+G+Y C+VSN  G  N +  + V+ + ++
Sbjct: 239 FNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQA 274



 Score = 31.6 bits (70), Expect = 1.8
 Identities = 29/100 (29%), Positives = 39/100 (39%), Gaps = 19/100 (19%)

Query: 43  LGRTVRLQCPVEGDPPPLTMWTK-----------DGRTI-----HSGWSRFRVLPQGLKV 86
           +G  V   C V  D  P   W K           DG        HSG +      + L +
Sbjct: 181 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNA--EVLAL 238

Query: 87  KQVEREDAGVYVCKATNGFGSLSVNYTLVVL-DDISPGKE 125
             V   DAG Y+CK +N  G  + +  L VL    +PG+E
Sbjct: 239 FNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGRE 278


>gi|222144239 fibroblast growth factor receptor 2 isoform 7
           precursor [Homo sapiens]
          Length = 705

 Score =  142 bits (359), Expect = 5e-34
 Identities = 84/260 (32%), Positives = 139/260 (53%), Gaps = 14/260 (5%)

Query: 40  VARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVL-PQGLKVKQVEREDAGVYV 98
           VA  G ++ ++C ++     +  WTKDG  +H G +   VL  + L++K     D+G+Y 
Sbjct: 51  VAAPGESLEVRCLLKD--AAVISWTKDG--VHLGPNNRTVLIGEYLQIKGATPRDSGLYA 106

Query: 99  CKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRR 158
           C A+    S +  + + V D IS G +    D +     + ++ + A P +T   KM +R
Sbjct: 107 CTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA-PYWTNTEKMEKR 165

Query: 159 VIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAA---EPRKKKWTLSLKNLRPED 215
           + A P  ++V+ +C A G+P P + W+K+ +   +       + R + W+L ++++ P D
Sbjct: 166 LHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSD 225

Query: 216 SGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVK 275
            G YTC V N  G+IN TY +DV++R+  +P+L    P N +   GG   F CKV SD +
Sbjct: 226 KGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQ 285

Query: 276 PVIQWLKRVE-----YGAEG 290
           P IQW+K VE     YG +G
Sbjct: 286 PHIQWIKHVEKNGSKYGPDG 305


>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
           [Homo sapiens]
          Length = 731

 Score =  140 bits (352), Expect = 4e-33
 Identities = 84/245 (34%), Positives = 121/245 (49%), Gaps = 14/245 (5%)

Query: 119 DISPGKESLGPDSSSGGQE---DPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVAS 175
           D  P  E    D  S  +E   D        P +T P KM +++ A P   +V+ KC +S
Sbjct: 31  DALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSS 90

Query: 176 GHPRPDITWMKDDQALT---RPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINA 232
           G P P + W+K+ +      R    + R   W++ + ++ P D G YTC V N  G+IN 
Sbjct: 91  GTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINH 150

Query: 233 TYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRH 292
           TY++DV++R+  +P+L    P N TV  G    F CKV SD +P IQWLK +E      +
Sbjct: 151 TYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEV-----N 205

Query: 293 NSTIDVGGQKFV-VLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSA 351
            S I      +V +L T  V        +  L +     +DAG Y CL  N++G S  SA
Sbjct: 206 GSKIGPDNLPYVQILKTAGV--NTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSA 263

Query: 352 FLTVL 356
           +LTVL
Sbjct: 264 WLTVL 268



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 65/273 (23%), Positives = 100/273 (36%), Gaps = 49/273 (17%)

Query: 20  PPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHS----GWS 75
           P A     P KM  K+         +TV+ +CP  G P P   W K+G+        G  
Sbjct: 59  PVAPYWTSPEKMEKKL---HAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGY 115

Query: 76  RFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGG 135
           + R     + +  V   D G Y C   N +GS++  Y L V++  SP +  L        
Sbjct: 116 KVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVER-SPHRPIL-------- 166

Query: 136 QEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDD------- 188
                          Q      + +A  +GS+V   C     P+P I W+K         
Sbjct: 167 ---------------QAGLPANKTVA--LGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI 209

Query: 189 --------QALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQ 240
                   Q L         K+   L L+N+  ED+G+YTC   N  G  + +  + V++
Sbjct: 210 GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE 269

Query: 241 RTRSKP-VLTGTHPVNTTVDFGGTTSFQCKVRS 272
               +P V+T    +   +   G     C V S
Sbjct: 270 ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGS 302


>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
           [Homo sapiens]
          Length = 733

 Score =  138 bits (347), Expect = 1e-32
 Identities = 83/247 (33%), Positives = 122/247 (49%), Gaps = 16/247 (6%)

Query: 119 DISPGKESLGPDSSSGGQEDPA-----SQQWARPRFTQPSKMRRRVIARPVGSSVRLKCV 173
           D  P  E    D  S  +E        ++    P +T P KM +++ A P   +V+ KC 
Sbjct: 31  DALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP 90

Query: 174 ASGHPRPDITWMKDDQALT---RPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAI 230
           +SG P P + W+K+ +      R    + R   W++ + ++ P D G YTC V N  G+I
Sbjct: 91  SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI 150

Query: 231 NATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEG 290
           N TY++DV++R+  +P+L    P N TV  G    F CKV SD +P IQWLK +E     
Sbjct: 151 NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEV---- 206

Query: 291 RHNSTIDVGGQKFV-VLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFR 349
            + S I      +V +L T  V        +  L +     +DAG Y CL  N++G S  
Sbjct: 207 -NGSKIGPDNLPYVQILKTAGV--NTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHH 263

Query: 350 SAFLTVL 356
           SA+LTVL
Sbjct: 264 SAWLTVL 270



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 65/273 (23%), Positives = 100/273 (36%), Gaps = 49/273 (17%)

Query: 20  PPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHS----GWS 75
           P A     P KM  K+         +TV+ +CP  G P P   W K+G+        G  
Sbjct: 61  PVAPYWTSPEKMEKKL---HAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGY 117

Query: 76  RFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGG 135
           + R     + +  V   D G Y C   N +GS++  Y L V++  SP +  L        
Sbjct: 118 KVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVER-SPHRPIL-------- 168

Query: 136 QEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDD------- 188
                          Q      + +A  +GS+V   C     P+P I W+K         
Sbjct: 169 ---------------QAGLPANKTVA--LGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI 211

Query: 189 --------QALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQ 240
                   Q L         K+   L L+N+  ED+G+YTC   N  G  + +  + V++
Sbjct: 212 GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE 271

Query: 241 RTRSKP-VLTGTHPVNTTVDFGGTTSFQCKVRS 272
               +P V+T    +   +   G     C V S
Sbjct: 272 ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGS 304


>gi|13186241 fibroblast growth factor receptor 1 isoform 6 precursor
           [Homo sapiens]
          Length = 300

 Score =  120 bits (302), Expect = 2e-27
 Identities = 62/173 (35%), Positives = 90/173 (52%), Gaps = 6/173 (3%)

Query: 119 DISPGKESLGPDSSSGGQE---DPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVAS 175
           D  P  E    D  S  +E   D        P +T P KM +++ A P   +V+ KC +S
Sbjct: 31  DALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSS 90

Query: 176 GHPRPDITWMKDDQALT---RPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINA 232
           G P P + W+K+ +      R    + R   W++ + ++ P D G YTC V N  G+IN 
Sbjct: 91  GTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINH 150

Query: 233 TYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVE 285
           TY++DV++R+  +P+L    P N TV  G    F CKV SD +P IQWLK +E
Sbjct: 151 TYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIE 203



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 43/171 (25%), Positives = 64/171 (37%), Gaps = 33/171 (19%)

Query: 20  PPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTI----HSGWS 75
           P A     P KM  K+         +TV+ +CP  G P P   W K+G+        G  
Sbjct: 59  PVAPYWTSPEKMEKKL---HAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGY 115

Query: 76  RFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGG 135
           + R     + +  V   D G Y C   N +GS++  Y L V++  SP +  L        
Sbjct: 116 KVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVER-SPHRPIL-------- 166

Query: 136 QEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMK 186
                          Q      + +A  +GS+V   C     P+P I W+K
Sbjct: 167 ---------------QAGLPANKTVA--LGSNVEFMCKVYSDPQPHIQWLK 200


>gi|13186238 fibroblast growth factor receptor 1 isoform 5 precursor
           [Homo sapiens]
          Length = 302

 Score =  119 bits (297), Expect = 8e-27
 Identities = 61/175 (34%), Positives = 91/175 (52%), Gaps = 8/175 (4%)

Query: 119 DISPGKESLGPDSSSGGQEDPA-----SQQWARPRFTQPSKMRRRVIARPVGSSVRLKCV 173
           D  P  E    D  S  +E        ++    P +T P KM +++ A P   +V+ KC 
Sbjct: 31  DALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP 90

Query: 174 ASGHPRPDITWMKDDQALT---RPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAI 230
           +SG P P + W+K+ +      R    + R   W++ + ++ P D G YTC V N  G+I
Sbjct: 91  SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI 150

Query: 231 NATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVE 285
           N TY++DV++R+  +P+L    P N TV  G    F CKV SD +P IQWLK +E
Sbjct: 151 NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIE 205



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 43/171 (25%), Positives = 64/171 (37%), Gaps = 33/171 (19%)

Query: 20  PPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTI----HSGWS 75
           P A     P KM  K+         +TV+ +CP  G P P   W K+G+        G  
Sbjct: 61  PVAPYWTSPEKMEKKL---HAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGY 117

Query: 76  RFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGG 135
           + R     + +  V   D G Y C   N +GS++  Y L V++  SP +  L        
Sbjct: 118 KVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVER-SPHRPIL-------- 168

Query: 136 QEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMK 186
                          Q      + +A  +GS+V   C     P+P I W+K
Sbjct: 169 ---------------QAGLPANKTVA--LGSNVEFMCKVYSDPQPHIQWLK 202


>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3783

 Score =  107 bits (268), Expect = 2e-23
 Identities = 105/375 (28%), Positives = 137/375 (36%), Gaps = 82/375 (21%)

Query: 29   PKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKVK 87
            P + +  +P      G    L C   G P P   W KDG+ +     +F + P G L VK
Sbjct: 2755 PPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVK 2814

Query: 88   QVEREDAGVYVCKATNGFGSL--SVNYTLVVLDDIS--PGKESLGPDSSSGGQEDPASQQ 143
             +E +DAG Y C A N  G     V+ T++VL   +  PG  SL                
Sbjct: 2815 NLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSL---------------- 2858

Query: 144  WARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKK 203
                                +G  + L+C A G P P I W  +D+ +T  E    +   
Sbjct: 2859 -------------------RLGDRLWLRCAARGSPTPRIGWTVNDRPVT--EGVSEQDGG 2897

Query: 204  WTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGT 263
             TL    +  EDSG Y C   NR G   A   V V    +  PVL G          GG+
Sbjct: 2898 STLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHV----KEAPVLQGEAFSYLVEPVGGS 2953

Query: 264  TSFQCKVRSDVKPVIQWLK--RVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLN 321
                C VR D  P I W+K      G+  RH             L  G            
Sbjct: 2954 IQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQ------------LQNG------------ 2989

Query: 322  KLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP----KP------PGPPVASSSS 371
             L I R  +DDAG Y CL  N MG + +   L +   P    +P       G  VA    
Sbjct: 2990 SLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQ 3049

Query: 372  ATSLPWPVVIGIPAG 386
            AT  P P +  + AG
Sbjct: 3050 ATGEPTPTIEWLQAG 3064



 Score =  102 bits (255), Expect = 6e-22
 Identities = 102/387 (26%), Positives = 142/387 (36%), Gaps = 71/387 (18%)

Query: 7    LLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKD 66
            LL+L PP++LG               +++V         TV LQCP  G+P P   W ++
Sbjct: 1554 LLVLTPPVILGD-------------TEELVEEVTVNASSTVSLQCPALGNPVPTISWLQN 1600

Query: 67   GRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGK 124
            G    S   R +VL  G  L+V   E  DA  Y+C A N  GS    +TL V   + P  
Sbjct: 1601 GLPF-SPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRV--QVPPRI 1657

Query: 125  ESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITW 184
              L  +                             +   + SSV L C    HP P++TW
Sbjct: 1658 AGLDLEQ----------------------------VTAILNSSVSLPCDVHAHPNPEVTW 1689

Query: 185  MKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRS 244
             KD QAL+  E         TL L   R  DSG YTC   N AG      ++ V+     
Sbjct: 1690 YKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAF 1749

Query: 245  KPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFV 304
            +    G       V  G      C+  +  +P + W K  +     +    +  GGQ   
Sbjct: 1750 RQAPRGPQDA-VLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALR-GGQ--- 1804

Query: 305  VLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGP 364
                             +L I  A+  D G+Y C  +N  G + R+  LTV   P    P
Sbjct: 1805 -----------------RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENP 1847

Query: 365  PVASSSSATSLPWPV---VIGIPAGAV 388
               + S     P  +   V G+PA  V
Sbjct: 1848 KTETVSQVAGSPLVLTCDVSGVPAPTV 1874



 Score = 99.8 bits (247), Expect = 5e-21
 Identities = 88/320 (27%), Positives = 129/320 (40%), Gaps = 61/320 (19%)

Query: 42   RLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKA 101
            RLG  + L+C   G P P   WT + R +  G S  +     L+   V RED+G YVC A
Sbjct: 2859 RLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSE-QDGGSTLQRAAVSREDSGTYVCWA 2917

Query: 102  TNGFG-SLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVI 160
             N  G + +V++  V                    +E P  Q  A              +
Sbjct: 2918 ENRVGRTQAVSFVHV--------------------KEAPVLQGEAFS-----------YL 2946

Query: 161  ARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYT 220
              PVG S++L CV  G P PDI W+KD   L R      + +  +L+++    +D+G+Y 
Sbjct: 2947 VEPVGGSIQLDCVVRGDPVPDIHWIKDGLPL-RGSHLRHQLQNGSLTIRRTERDDAGRYQ 3005

Query: 221  CRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQW 280
            C   N  G      K  VI   +S PV     P + TV  G   + +C+   +  P I+W
Sbjct: 3006 CLAENEMGVA----KKVVILVLQSAPVFQ-VEPQDMTVRSGDDVALRCQATGEPTPTIEW 3060

Query: 281  LKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLG 340
            L+  +     R   T          LP G +W            +      DAG Y C+ 
Sbjct: 3061 LQAGQPLRASRRLRT----------LPDGSLW------------LENVETGDAGTYDCVA 3098

Query: 341  ANTMGYSFRSAFLTVLPDPK 360
             N +G +   AFL V  +P+
Sbjct: 3099 HNLLGSATARAFLVVRGEPQ 3118



 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 94/369 (25%), Positives = 161/369 (43%), Gaps = 48/369 (13%)

Query: 20   PPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRV 79
            PP+ +   P  +A+  V     ++  T+ L+C     PPP   W KDG+ +    SR +V
Sbjct: 1350 PPSISKDDP--LAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPS-SRLQV 1406

Query: 80   LPQG--LKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQE 137
            L +G  L+++  +  D+G Y+C ATN  G    ++ +++   + P  + +G  S++   E
Sbjct: 1407 LGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI--QVPPMFQKVGDFSAAF--E 1462

Query: 138  DPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAA 197
              + ++ AR   T+     R ++     +   L C  +  P PD+TW ++DQ L+  +  
Sbjct: 1463 ILSREEEARGGVTE----YREIVEN---NPAYLYCDTNAIPPPDLTWYREDQPLSAGDEV 1515

Query: 198  EPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHP---V 254
               +    L +  +R E++G+Y+C+ SN  G     Y++ V+    + PV+ G       
Sbjct: 1516 SVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVL----TPPVILGDTEELVE 1571

Query: 255  NTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSR 314
              TV+   T S QC    +  P I WL+          N        +  VL  G V   
Sbjct: 1572 EVTVNASSTVSLQCPALGNPVPTISWLQ----------NGLPFSPSPRLQVLEDGQV--- 1618

Query: 315  PDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPG----PPVASSS 370
                    L ++ A   DA  Y+C+  N  G + +   L V   P+  G       A  +
Sbjct: 1619 --------LQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILN 1670

Query: 371  SATSLPWPV 379
            S+ SLP  V
Sbjct: 1671 SSVSLPCDV 1679



 Score = 97.1 bits (240), Expect = 3e-20
 Identities = 89/325 (27%), Positives = 132/325 (40%), Gaps = 57/325 (17%)

Query: 28   PPKMADKVVPRQVARL-GRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--L 84
            PP + ++ +   +  L G+T  L C V G P P   W KDGR +  G     + P G  L
Sbjct: 1161 PPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARG-DAHHISPDGVLL 1219

Query: 85   KVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQW 144
            +V Q     AG Y C A N  G  + ++ L VL         L P +  GG ED A ++ 
Sbjct: 1220 QVLQANLSSAGHYSCIAANAVGEKTKHFQLSVL---------LAP-TILGGAEDSADEE- 1268

Query: 145  ARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKW 204
                           +   V + + L C A   P P+ITWMKD          +      
Sbjct: 1269 ---------------VTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTH 1313

Query: 205  TLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVI---QRTRSKPVL-TGTHPVNTTVDF 260
             L + N + ED+G+YTC V+N  G     Y V+V+     ++  P+   G   V T V+ 
Sbjct: 1314 GLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVN- 1372

Query: 261  GGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYL 320
              T + +C+  +   P I+W K                 GQ   V P+  +    +G  L
Sbjct: 1373 -STLTLECESWAVPPPTIRWYK----------------DGQP--VTPSSRLQVLGEGRLL 1413

Query: 321  NKLLITRARQDDAGMYICLGANTMG 345
                I   +  D+G Y+C+  N  G
Sbjct: 1414 Q---IQPTQVSDSGRYLCVATNVAG 1435



 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 87/314 (27%), Positives = 122/314 (38%), Gaps = 61/314 (19%)

Query: 47   VRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKVKQVEREDAGVYVCKATNGF 105
            V L C   G P P   W K+G  + +G S  +VLP G L++     EDAG Y+C A N  
Sbjct: 2683 VLLPCEASGIPRPTITWQKEGLNVATGVST-QVLPGGQLRIAHASPEDAGNYLCIAKNSA 2741

Query: 106  GSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVG 165
            GS      LVV   + P  E+  PD S+                               G
Sbjct: 2742 GSAMGKTRLVV--QVPPVIENGLPDLST-----------------------------TEG 2770

Query: 166  SSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSN 225
            S   L C A G P P+ITW KD Q ++  E     +    L +KNL  +D+G YTC   N
Sbjct: 2771 SHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAEN 2830

Query: 226  RAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVE 285
              G       + ++      PV T T P + ++  G     +C  R    P I W     
Sbjct: 2831 AVGRARRRVHLTIL----VLPVFT-TLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDR 2885

Query: 286  YGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMG 345
               EG                    V  +  GS L +  ++R   +D+G Y+C   N +G
Sbjct: 2886 PVTEG--------------------VSEQDGGSTLQRAAVSR---EDSGTYVCWAENRVG 2922

Query: 346  YSFRSAFLTVLPDP 359
             +   +F+ V   P
Sbjct: 2923 RTQAVSFVHVKEAP 2936



 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 93/335 (27%), Positives = 127/335 (37%), Gaps = 64/335 (19%)

Query: 28   PPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKV 86
            PP +AD      V  +   V L C   G P P   W+K G  + +  S +RV P G L++
Sbjct: 2574 PPTIADDQTDFTVTMMAPVV-LTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEI 2632

Query: 87   KQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWAR 146
             Q     AG Y C A N  G    +  L V                   Q  P       
Sbjct: 2633 GQALPIHAGRYTCSARNSAGVAHKHVFLTV-------------------QASPV------ 2667

Query: 147  PRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTL 206
                +P     R +A      V L C ASG PRP ITW K+   +    + +       L
Sbjct: 2668 ---VKPLPSVVRAVAE---EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQV-LPGGQL 2720

Query: 207  SLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSF 266
             + +  PED+G Y C   N AG+     ++ V    +  PV+    P  +T + G     
Sbjct: 2721 RIAHASPEDAGNYLCIAKNSAGSAMGKTRLVV----QVPPVIENGLPDLSTTE-GSHAFL 2775

Query: 267  QCKVRSDVKPVIQWLK--RVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLL 324
             CK R   +P I W K  +   GAEG           KF + P+G+            LL
Sbjct: 2776 PCKARGSPEPNITWDKDGQPVSGAEG-----------KFTIQPSGE------------LL 2812

Query: 325  ITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP 359
            +      DAG Y C   N +G + R   LT+L  P
Sbjct: 2813 VKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLP 2847



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 80/336 (23%), Positives = 125/336 (37%), Gaps = 57/336 (16%)

Query: 28   PPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLP--QGLK 85
            PP++A   + +  A L  +V L C V   P P   W KD + +  G   F +LP    L+
Sbjct: 1654 PPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVF-LLPGTHTLQ 1712

Query: 86   VKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWA 145
            + +    D+G+Y C+A N  G    +  LV L  + P                       
Sbjct: 1713 LGRARLSDSGMYTCEALNAAGR---DQKLVQLSVLVP----------------------- 1746

Query: 146  RPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWT 205
             P F Q  +  +  +   VG    L C     P P +TW KD Q L   +  +  +    
Sbjct: 1747 -PAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQR 1805

Query: 206  LSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTS 265
            L ++  +  D G Y+C+VSN AG    T+ + V    +  P          +   G    
Sbjct: 1806 LEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTV----QVPPTFENPKTETVSQVAGSPLV 1861

Query: 266  FQCKVRSDVKPVIQWLK-RVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLL 324
              C V     P + WLK R+   +   H   +  GG                     +L 
Sbjct: 1862 LTCDVSGVPAPTVTWLKDRMPVESSAVH-GVVSRGG---------------------RLQ 1899

Query: 325  ITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPK 360
            ++R +   AG Y C+  NT   + +   + VL  P+
Sbjct: 1900 LSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPR 1935



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 86/320 (26%), Positives = 119/320 (37%), Gaps = 60/320 (18%)

Query: 43   LGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKVKQVEREDAGVYVCKA 101
            + +T  L C  +G P PL  W KD   +     RF +LP+G L+++ V  +DAG Y+C A
Sbjct: 2404 VNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLA 2463

Query: 102  TNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIA 161
            +N  GS      L VL+                            P    PS     + A
Sbjct: 2464 SNSAGSDRQGRDLRVLE----------------------------PPAIAPSPSNLTLTA 2495

Query: 162  RPVGSSVRLKCVASGHPRPDITWMKDDQAL--TRPEAAEPRKKKWTLSLKNLRPEDSGKY 219
                +   L C ASG P+P + W KD Q L     + A        L L    P+DS ++
Sbjct: 2496 H---TPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQF 2552

Query: 220  TCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQ 279
             C VSN  G  +  Y+V V       P        + TV         C       P + 
Sbjct: 2553 ECVVSNEVGEAHRLYQVTV-----HVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVS 2607

Query: 280  WLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICL 339
            W K    GA+      +   G  + V P+G             L I +A    AG Y C 
Sbjct: 2608 WSKA---GAQ------LGARGSGYRVSPSG------------ALEIGQALPIHAGRYTCS 2646

Query: 340  GANTMGYSFRSAFLTVLPDP 359
              N+ G + +  FLTV   P
Sbjct: 2647 ARNSAGVAHKHVFLTVQASP 2666



 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 92/378 (24%), Positives = 147/378 (38%), Gaps = 69/378 (18%)

Query: 28   PPKMADKVVPRQVARL-GRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGLKV 86
            PP + D   P +++   G  + L C  +G P P   W KDG+ +    +R     +  +V
Sbjct: 2211 PPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL----TRLENNSRATRV 2266

Query: 87   KQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWAR 146
             +V   DAG+Y C A +  G++  ++ + V                   Q  P       
Sbjct: 2267 LRVR--DAGLYTCLAESPAGAIEKSFRVRV-------------------QAPPNIVGPRG 2305

Query: 147  PRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTL 206
            PRF         V+    G  V L+C     P P ITW +D   L      +  ++   L
Sbjct: 2306 PRF---------VVGLAPGQLV-LECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFL 2355

Query: 207  SLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVL-TGTHPVNTTVDFGGTTS 265
             L+ L   DSG Y+C   N AG+ +  ++V++     + P + +G   VN +V+   T  
Sbjct: 2356 QLQALSTADSGDYSCTARNAAGSTSVAFRVEI----HTVPTIRSGPPAVNVSVN--QTAL 2409

Query: 266  FQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLI 325
              C+      P++ W K             +D    +F +LP G +  +P          
Sbjct: 2410 LPCQADGVPAPLVSWRK---------DRVPLDPRSPRFEILPEGSLRIQP---------- 2450

Query: 326  TRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIPA 385
                  DAG Y+CL +N+ G   +   L VL       P +A S S  +L       +P 
Sbjct: 2451 --VLAQDAGHYLCLASNSAGSDRQGRDLRVLEP-----PAIAPSPSNLTLTAHTPALLPC 2503

Query: 386  GAVFILGTLLLWLCQAQK 403
             A      L++W    QK
Sbjct: 2504 EASGSPKPLVVWWKDGQK 2521



 Score = 86.3 bits (212), Expect = 6e-17
 Identities = 95/370 (25%), Positives = 143/370 (38%), Gaps = 77/370 (20%)

Query: 28  PPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--LK 85
           PP +    V + V     +V L+C   G PPP   W K  + + S W    V   G  L+
Sbjct: 603 PPNIEPGPVNKAVLE-NASVTLECLASGVPPPDVSWFKGHQPV-SSWMGVTVSVDGRVLR 660

Query: 86  VKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWA 145
           ++Q +  DAG Y C A+N  GS  + Y L V                             
Sbjct: 661 IEQAQLSDAGSYRCVASNVAGSTELRYGLRVN---------------------------V 693

Query: 146 RPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKW- 204
            PR T P  +   V+   V + VRL C A+G P P + W+KD   ++   A  P  + + 
Sbjct: 694 PPRITLPPSLPGPVL---VNTPVRLTCNATGAPSPTLMWLKDGNPVS--PAGTPGLQVFP 748

Query: 205 ---TLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFG 261
               L+L + R  DSG+Y+C   +  G      + DV+ +    P + G   +N +V   
Sbjct: 749 GGRVLTLASARASDSGRYSCVAVSAVG----EDRQDVVLQVHMPPSILG-EELNVSVVAN 803

Query: 262 GTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLN 321
            + + +C+  +   PV+ W K      +GR             + P   V    D + L 
Sbjct: 804 ESVALECQSHAMPPPVLSWWK------DGR------------PLEPRPGVHLSADKALLQ 845

Query: 322 KLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPP-----------GPPVASSS 370
              + RA   DAG Y C   N  G+S +   L V   P  P           G P   S 
Sbjct: 846 ---VDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTRLSC 902

Query: 371 SATSLPWPVV 380
               +P+P +
Sbjct: 903 ECRGVPFPKI 912



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 84/355 (23%), Positives = 132/355 (37%), Gaps = 67/355 (18%)

Query: 7    LLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKD 66
            L +L+PP L+G   P              +    A L   + L C   G PPP   W + 
Sbjct: 1062 LSVLVPPELIGDLDP--------------LTNITAALHSPLTLLCEAMGIPPPAIRWFRG 1107

Query: 67   GRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGK 124
               +  G   + +L  G  LK+ Q + +D+G+Y C A+N  G    N+++ VL   S   
Sbjct: 1108 EEPVSPGEDTY-LLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIEN 1166

Query: 125  ESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITW 184
            E L                               VI    G +  L C  +GHP+P +TW
Sbjct: 1167 EDL-----------------------------EEVIKVLDGQTAHLMCNVTGHPQPKLTW 1197

Query: 185  MKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRS 244
             KD + L R +A         L +       +G Y+C  +N  G     +++ V+     
Sbjct: 1198 FKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTI 1257

Query: 245  KPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFV 304
                  +     TV      S  C+  +   P I W+K    GA    +  I        
Sbjct: 1258 LGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKD---GAPFEASRNIQ------- 1307

Query: 305  VLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP 359
            +LP             + L I  A+++DAG Y C+  N +G + ++  + VL  P
Sbjct: 1308 LLPG-----------THGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPP 1351



 Score = 83.6 bits (205), Expect = 4e-16
 Identities = 84/359 (23%), Positives = 133/359 (37%), Gaps = 69/359 (19%)

Query: 49   LQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCKATNGFG 106
            L C     PPP   W ++ + + +G     VL  G  L++  V  E+AG Y CKA+N  G
Sbjct: 1488 LYCDTNAIPPPDLTWYREDQPLSAG-DEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVG 1546

Query: 107  SLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGS 166
               ++Y L+VL           P    G  E+   +                 +     S
Sbjct: 1547 EDWLHYELLVLT----------PPVILGDTEELVEE-----------------VTVNASS 1579

Query: 167  SVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNR 226
            +V L+C A G+P P I+W+++    +     +  +    L +      D+  Y C   N+
Sbjct: 1580 TVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQ 1639

Query: 227  AGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEY 286
            AG+    + +    R +  P + G      T     + S  C V +   P + W K    
Sbjct: 1640 AGSAEKLFTL----RVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYK---- 1691

Query: 287  GAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGY 346
                  +  + +G + F++  T            + L + RAR  D+GMY C   N  G 
Sbjct: 1692 -----DSQALSLGEEVFLLPGT------------HTLQLGRARLSDSGMYTCEALNAAGR 1734

Query: 347  SFRSAFLTVLPDP----KPPGPPVA----------SSSSATSLPWPVVIGIPAGAVFIL 391
              +   L+VL  P     P GP  A           S    +LP P V     G   +L
Sbjct: 1735 DQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVL 1793



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 102/410 (24%), Positives = 149/410 (36%), Gaps = 85/410 (20%)

Query: 20   PPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWS-RFR 78
            P  A  R PP     VV   VA L      +C   G PPP   W +DG+ + +    + +
Sbjct: 974  PQIAGPREPPTQVS-VVQDGVATL------ECNATGKPPPTVTWERDGQPVGAELGLQLQ 1026

Query: 79   VLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQED 138
               Q L V++ +    G Y C A N  G     + L VL         + P+    G  D
Sbjct: 1027 NQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVL---------VPPELI--GDLD 1075

Query: 139  PASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAE 198
            P +                  I   + S + L C A G P P I W + ++ ++  E   
Sbjct: 1076 PLTN-----------------ITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTY 1118

Query: 199  PRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTV 258
                 W L +   + +DSG Y+C  SN AG     + V+V+     +        V   +
Sbjct: 1119 LLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIEN--EDLEEVIKVL 1176

Query: 259  DFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWS-RPDG 317
            D G T    C V    +P + W K      +GR              L  GD     PDG
Sbjct: 1177 D-GQTAHLMCNVTGHPQPKLTWFK------DGR-------------PLARGDAHHISPDG 1216

Query: 318  SYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPG-------------- 363
              L    + +A    AG Y C+ AN +G   +   L+VL  P   G              
Sbjct: 1217 VLLQ---VLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTV 1273

Query: 364  -PPVASSSSATSLPWPVVIGIPAGAVF--------ILGTLLLWLCQAQKK 404
              P++    A + P P +  +  GA F        + GT  L +  AQK+
Sbjct: 1274 NNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKE 1323



 Score = 79.3 bits (194), Expect = 7e-15
 Identities = 74/282 (26%), Positives = 106/282 (37%), Gaps = 58/282 (20%)

Query: 80  LPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDP 139
           LP  L++++V+  D G+Y C ATN  G       L VL                      
Sbjct: 564 LPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLV--------------------- 602

Query: 140 ASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEP 199
                  P   +P  + + V+     +SV L+C+ASG P PD++W K  Q ++       
Sbjct: 603 -------PPNIEPGPVNKAVLEN---ASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTV 652

Query: 200 RKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATY--KVDVIQRTRSKPVLTGTHPVNTT 257
                 L ++  +  D+G Y C  SN AG+    Y  +V+V  R    P L G   VNT 
Sbjct: 653 SVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTP 712

Query: 258 VDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDG 317
           V         C       P + WLK      +G  N     G     V P G V      
Sbjct: 713 V------RLTCNATGAPSPTLMWLK------DG--NPVSPAGTPGLQVFPGGRV------ 752

Query: 318 SYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP 359
                L +  AR  D+G Y C+  + +G   +   L V   P
Sbjct: 753 -----LTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPP 789



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 81/329 (24%), Positives = 124/329 (37%), Gaps = 71/329 (21%)

Query: 40   VARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG----LKVKQVEREDAG 95
            V+R G  V + CPV G PP    W KDG  +       R L  G    L++ +V+  DAG
Sbjct: 2042 VSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQ---RTLLHGSGHTLRISKVQLADAG 2098

Query: 96   VYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKM 155
            ++ C A +  G    N+TL V                              P   +P + 
Sbjct: 2099 IFTCVAASPAGVADRNFTLQV----------------------------QVPPVLEPVEF 2130

Query: 156  RRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPED 215
            +  V+    GS V L C A G P P ++WMKD +    P  ++  ++  +L L+ +   D
Sbjct: 2131 QNDVVVVR-GSLVELPCEARGVPLPLVSWMKDGE----PLLSQSLEQGPSLQLEAVGAGD 2185

Query: 216  SGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVK 275
            SG Y+C   + AG     +++ V++      +     P   ++  G      C  +   +
Sbjct: 2186 SGTYSCVAVSEAGEARRHFQLTVMEPPH---IEDSGQPTELSLTPGAPMELLCDAQGTPQ 2242

Query: 276  PVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGM 335
            P I W K                 GQ    L      +R          + R R  DAG+
Sbjct: 2243 PNITWHK----------------DGQALTRLENNSRATR----------VLRVR--DAGL 2274

Query: 336  YICLGANTMGYSFRSAFLTVLPDPKPPGP 364
            Y CL  +  G   +S  + V   P   GP
Sbjct: 2275 YTCLAESPAGAIEKSFRVRVQAPPNIVGP 2303



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 75/323 (23%), Positives = 125/323 (38%), Gaps = 58/323 (17%)

Query: 42   RLGRTVRLQCPVEGDPPPLTMWTKDGRTIH---SGWSRFRVLPQGLKVKQVEREDAGVYV 98
            R G   RL C   G P P   W KDG+ +    +G      + + L + Q +    G Y 
Sbjct: 893  REGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYT 952

Query: 99   CKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRR 158
            C+ +N  G+ S +  L          E   P   +G +E P          TQ S ++  
Sbjct: 953  CECSNVVGNSSQDLQL----------EVHVPPQIAGPREPP----------TQVSVVQDG 992

Query: 159  VIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGK 218
            V          L+C A+G P P +TW +D Q +      + + +  +L ++  +   +G+
Sbjct: 993  VAT--------LECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGR 1044

Query: 219  YTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHP--VNTTVDFGGTTSFQCKVRSDVKP 276
            Y+C   N AG     +++ V+      P L G      N T       +  C+      P
Sbjct: 1045 YSCVAENLAGRAERKFELSVL----VPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPP 1100

Query: 277  VIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMY 336
             I+W +  E  + G     +  G            W          L +T+ ++ D+G+Y
Sbjct: 1101 AIRWFRGEEPVSPGEDTYLLAGG------------W---------MLKMTQTQEQDSGLY 1139

Query: 337  ICLGANTMGYSFRSAFLTVLPDP 359
             CL +N  G + R+  + VL  P
Sbjct: 1140 SCLASNEAGEARRNFSVEVLVPP 1162



 Score = 77.0 bits (188), Expect = 4e-14
 Identities = 82/351 (23%), Positives = 125/351 (35%), Gaps = 73/351 (20%)

Query: 44   GRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWS---RFRVLPQGLKVKQVEREDAGVYVCK 100
            G+ VRL C  +G PPP   W KDG  +        RF +    L +K +   DAG Y C 
Sbjct: 1950 GQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCV 2009

Query: 101  ATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVI 160
            A N  G  +  +T+ VL    P     G D S                          ++
Sbjct: 2010 AHNPAGEDARLHTVNVL---VPPTIKQGADGSG------------------------TLV 2042

Query: 161  ARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYT 220
            +RP G  V + C   G P   ++W+KD   L   +         TL +  ++  D+G +T
Sbjct: 2043 SRP-GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFT 2101

Query: 221  CRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDF-GGTTSFQCKVRSDVKPVIQ 279
            C  ++ AG  +  + + V    +  PVL      N  V   G      C+ R    P++ 
Sbjct: 2102 CVAASPAGVADRNFTLQV----QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVS 2157

Query: 280  WLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICL 339
            W+K      E   + +++ G                       L +      D+G Y C+
Sbjct: 2158 WMK----DGEPLLSQSLEQG---------------------PSLQLEAVGAGDSGTYSCV 2192

Query: 340  GANTMGYSFRSAFLTVLPDPK------------PPGPPVASSSSATSLPWP 378
              +  G + R   LTV+  P              PG P+     A   P P
Sbjct: 2193 AVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQP 2243



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 98/410 (23%), Positives = 147/410 (35%), Gaps = 69/410 (16%)

Query: 43  LGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCK 100
           +G+ + L C   G P P   W ++GR      +  +V  QG  L +  VE + +G++ C+
Sbjct: 421 VGQPLELPCQASGSPVPTIQWLQNGRPAEE-LAGVQVASQGTTLHIDHVELDHSGLFACQ 479

Query: 101 ATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVI 160
           ATN  G+      + V  + +PG   +       G E  +S     P    P       +
Sbjct: 480 ATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSF----PAACDPP------V 529

Query: 161 ARPVGSSVRLKCVASGHPRPDIT--WMKDDQALTRPEAAEPRKK-KWTLSLKNLRPEDSG 217
            R  G+          HP+P +   W         P            L ++ +   D G
Sbjct: 530 HRGWGA----------HPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEG 579

Query: 218 KYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPV 277
            YTC  +N AG       + V+     +P      PVN  V    + + +C       P 
Sbjct: 580 IYTCAATNLAGESKREVALKVLVPPNIEP-----GPVNKAVLENASVTLECLASGVPPPD 634

Query: 278 IQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYI 337
           + W K  +         T+ V G+                     L I +A+  DAG Y 
Sbjct: 635 VSWFKGHQ-PVSSWMGVTVSVDGRV--------------------LRIEQAQLSDAGSYR 673

Query: 338 CLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIP----AGAVFILGT 393
           C+ +N  G +     L V   P+   PP        SLP PV++  P      A      
Sbjct: 674 CVASNVAGSTELRYGLRVNVPPRITLPP--------SLPGPVLVNTPVRLTCNATGAPSP 725

Query: 394 LLLWLCQAQKKPCTPAPAPPL---PGHRPPGTARDRSGDKDLPSLAALSA 440
            L+WL      P +PA  P L   PG R    A  R+ D    S  A+SA
Sbjct: 726 TLMWL--KDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSA 773



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 78/302 (25%), Positives = 110/302 (36%), Gaps = 57/302 (18%)

Query: 47  VRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG---LKVKQVEREDAGVYVCKATN 103
           V+L C   G P P   W KDG  + +  S   V  +G   L++ + +  DAGVY CKA+N
Sbjct: 238 VQLLCEARGVPTPNITWFKDGALLPT--STKVVYTRGGRQLQLGRAQSSDAGVYTCKASN 295

Query: 104 GFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARP 163
             G+      L V   + P  E  G                           R  V+   
Sbjct: 296 AVGAAEKATRLDVY--VPPTIEGAGG--------------------------RPYVVKAV 327

Query: 164 VGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRV 223
            G  V L+CVA GHP P ++W  +   +     +        L L++     SG Y+C  
Sbjct: 328 AGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVA 387

Query: 224 SNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKR 283
           S+ AG     Y V+V Q      V  G   V T V  G      C+      P IQWL+ 
Sbjct: 388 SSPAGEAVLQYSVEV-QVPPQLLVAEGLGQVTTIV--GQPLELPCQASGSPVPTIQWLQN 444

Query: 284 VEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANT 343
              G      + + V  Q               G+ L+   I     D +G++ C   N 
Sbjct: 445 ---GRPAEELAGVQVASQ---------------GTTLH---IDHVELDHSGLFACQATNE 483

Query: 344 MG 345
            G
Sbjct: 484 AG 485



 Score = 73.6 bits (179), Expect = 4e-13
 Identities = 91/402 (22%), Positives = 145/402 (36%), Gaps = 90/402 (22%)

Query: 7    LLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKD 66
            L +LL P +LG         G    AD+ V      +   + L C     P P   W KD
Sbjct: 1249 LSVLLAPTILG---------GAEDSADEEV---TVTVNNPISLICEALAFPSPNITWMKD 1296

Query: 67   GRTIHSGWSRFRVLP--QGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGK 124
            G    +     ++LP   GL++   ++EDAG Y C  TN  G    NY + VL  I P  
Sbjct: 1297 GAPFEAS-RNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVL--IPP-- 1351

Query: 125  ESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITW 184
                    S  ++DP ++   +             +   V S++ L+C +   P P I W
Sbjct: 1352 --------SISKDDPLAEVGVKE------------VKTKVNSTLTLECESWAVPPPTIRW 1391

Query: 185  MKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRS 244
             KD Q +T     +   +   L ++  +  DSG+Y C  +N AG  +  + V +    + 
Sbjct: 1392 YKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI----QV 1447

Query: 245  KPVLTGTHPVNTTVDF--------GGTTSFQ-----------CKVRSDVKPVIQWLKRVE 285
             P+       +   +         GG T ++           C   +   P + W +  +
Sbjct: 1448 PPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQ 1507

Query: 286  YGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMG 345
              + G   S +  G                       L I   R ++AG Y C  +N +G
Sbjct: 1508 PLSAGDEVSVLQGG---------------------RVLQIPLVRAENAGRYSCKASNEVG 1546

Query: 346  YSFRSAFLTVLPDPKPPGPP-------VASSSSATSLPWPVV 380
              +    L VL  P   G           ++SS  SL  P +
Sbjct: 1547 EDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPAL 1588



 Score = 72.8 bits (177), Expect = 7e-13
 Identities = 98/404 (24%), Positives = 139/404 (34%), Gaps = 92/404 (22%)

Query: 7   LLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKD 66
           LL+L PP +LGA     AA+    +A           G  V LQC   G P P   WTKD
Sbjct: 119 LLVLTPPSVLGA----GAAQEVLGLA-----------GADVELQCWTSGVPTPQVEWTKD 163

Query: 67  GRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGK 124
            + +  G    +V   G  L++      D G Y C A +  G  + ++ L V        
Sbjct: 164 RQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVH------- 216

Query: 125 ESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITW 184
               P +  G  E                      +A      V+L C A G P P+ITW
Sbjct: 217 ---APPTIWGSNETGE-------------------VAVMEDHLVQLLCEARGVPTPNITW 254

Query: 185 MKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRS 244
            KD   L         +    L L   +  D+G YTC+ SN  GA     ++DV      
Sbjct: 255 FKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY----V 310

Query: 245 KPVLTGT--HPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQK 302
            P + G    P       G   + +C  R    P + W           H+  + V    
Sbjct: 311 PPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSW-----------HHEGLPVAESN 359

Query: 303 FVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPP 362
              L T       DGS L    +    +  +G+Y C+ ++                  P 
Sbjct: 360 ESRLET-------DGSVLR---LESPGEASSGLYSCVASS------------------PA 391

Query: 363 GPPVASSSSATSLPWPVVIGIPAGAV-FILGTLLLWLCQAQKKP 405
           G  V   S    +P  +++    G V  I+G  L   CQA   P
Sbjct: 392 GEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSP 435



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 80/340 (23%), Positives = 134/340 (39%), Gaps = 76/340 (22%)

Query: 44  GRTVRLQCPVEGDPPPLTMWTKDGRTIHS--GWSRF------------RVLPQG--LKVK 87
           G+++ L+C   G P P  +W KD + +    GW+ +            R+L +G  L   
Sbjct: 33  GQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFP 92

Query: 88  QVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARP 147
           +++  D+G+Y C+A N  G+   ++ L+VL           P S  G     A+Q+    
Sbjct: 93  RIQEGDSGLYSCRAENQAGTAQRDFHLLVLT----------PPSVLGA---GAAQE---- 135

Query: 148 RFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQ-ALTRPEAAEPRKKKWTL 206
                       +    G+ V L+C  SG P P + W KD Q  L      + ++    L
Sbjct: 136 ------------VLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVL 183

Query: 207 SLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPV-NTTVDFGGTTS 265
            +      D G+Y C   + AG     +++    R  + P + G++      V       
Sbjct: 184 RITGSHVGDEGRYQCVAFSPAGQQARDFQL----RVHAPPTIWGSNETGEVAVMEDHLVQ 239

Query: 266 FQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGD--VWSRPDGSYLNKL 323
             C+ R    P I W K      +G              +LPT    V++R       +L
Sbjct: 240 LLCEARGVPTPNITWFK------DG-------------ALLPTSTKVVYTRGG----RQL 276

Query: 324 LITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPG 363
            + RA+  DAG+Y C  +N +G + ++  L V   P   G
Sbjct: 277 QLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEG 316



 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 81/321 (25%), Positives = 111/321 (34%), Gaps = 57/321 (17%)

Query: 47  VRLQCPVEGDPPPLTMWTKDGRTIH-SGWSRFRVLPQG--LKVKQVEREDAGVYVCKATN 103
           VRL C   G P P  MW KDG  +  +G    +V P G  L +      D+G Y C A +
Sbjct: 713 VRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVS 772

Query: 104 GFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARP 163
             G    +  L V            P S  G                   ++   V+A  
Sbjct: 773 AVGEDRQDVVLQVHM----------PPSILG------------------EELNVSVVAN- 803

Query: 164 VGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRV 223
              SV L+C +   P P ++W KD + L           K  L +      D+G YTC  
Sbjct: 804 --ESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEA 861

Query: 224 SNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKR 283
            N+AG     Y ++V       PV         TV  G  T   C+ R    P I W K 
Sbjct: 862 LNQAGHSEKHYNLNV----WVAPVFPLRESHTLTVREGHPTRLSCECRGVPFPKISWRK- 916

Query: 284 VEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANT 343
                           GQ    LP      +   +    L + +A+    G Y C  +N 
Sbjct: 917 ---------------DGQP---LPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNV 958

Query: 344 MGYSFRSAFLTVLPDPKPPGP 364
           +G S +   L V   P+  GP
Sbjct: 959 VGNSSQDLQLEVHVPPQIAGP 979



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 53/220 (24%), Positives = 79/220 (35%), Gaps = 40/220 (18%)

Query: 156 RRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRP--EAAEPRKKKW--------- 204
           R+  ++   G S+ L+C A+G P P+I W+KD Q +  P   A       W         
Sbjct: 24  RKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLL 83

Query: 205 ----TLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDF 260
               +L    ++  DSG Y+CR  N+AG     + + V+    + P + G       +  
Sbjct: 84  DEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVL----TPPSVLGAGAAQEVLGL 139

Query: 261 GGT-TSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSY 319
            G     QC       P ++W K             +  GG    V   G V        
Sbjct: 140 AGADVELQCWTSGVPTPQVEWTK---------DRQPVLPGGPHLQVQEDGQV-------- 182

Query: 320 LNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP 359
              L IT +   D G Y C+  +  G   R   L V   P
Sbjct: 183 ---LRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPP 219


>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3874

 Score =  107 bits (267), Expect = 3e-23
 Identities = 105/375 (28%), Positives = 137/375 (36%), Gaps = 82/375 (21%)

Query: 29   PKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKVK 87
            P + +  +P      G    L C   G P P   W KDG+ +     +F + P G L VK
Sbjct: 2846 PPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVK 2905

Query: 88   QVEREDAGVYVCKATNGFGSL--SVNYTLVVLDDIS--PGKESLGPDSSSGGQEDPASQQ 143
             +E +DAG Y C A N  G     V+ T++VL   +  PG  SL                
Sbjct: 2906 NLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSL---------------- 2949

Query: 144  WARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKK 203
                                +G  + L+C A G P P I W  +D+ +T  E    +   
Sbjct: 2950 -------------------RLGDRLWLRCAARGSPTPRIGWTVNDRPVT--EGVSEQDGG 2988

Query: 204  WTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGT 263
             TL    +  EDSG Y C   NR G   A   V V    +  PVL G          GG+
Sbjct: 2989 STLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHV----KEAPVLQGEAFSYLVEPVGGS 3044

Query: 264  TSFQCKVRSDVKPVIQWLK--RVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLN 321
                C VR D  P I W+K      G+  RH             L  G            
Sbjct: 3045 IQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQ------------LQNG------------ 3080

Query: 322  KLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP----KP------PGPPVASSSS 371
             L I R  +DDAG Y CL  N MG + +   L +   P    +P       G  VA    
Sbjct: 3081 SLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQ 3140

Query: 372  ATSLPWPVVIGIPAG 386
            AT  P P +  + AG
Sbjct: 3141 ATGEPTPTIEWLQAG 3155



 Score =  102 bits (255), Expect = 6e-22
 Identities = 102/387 (26%), Positives = 142/387 (36%), Gaps = 71/387 (18%)

Query: 7    LLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKD 66
            LL+L PP++LG               +++V         TV LQCP  G+P P   W ++
Sbjct: 1645 LLVLTPPVILGD-------------TEELVEEVTVNASSTVSLQCPALGNPVPTISWLQN 1691

Query: 67   GRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGK 124
            G    S   R +VL  G  L+V   E  DA  Y+C A N  GS    +TL V   + P  
Sbjct: 1692 GLPF-SPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRV--QVPPRI 1748

Query: 125  ESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITW 184
              L  +                             +   + SSV L C    HP P++TW
Sbjct: 1749 AGLDLEQ----------------------------VTAILNSSVSLPCDVHAHPNPEVTW 1780

Query: 185  MKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRS 244
             KD QAL+  E         TL L   R  DSG YTC   N AG      ++ V+     
Sbjct: 1781 YKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAF 1840

Query: 245  KPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFV 304
            +    G       V  G      C+  +  +P + W K  +     +    +  GGQ   
Sbjct: 1841 RQAPRGPQDA-VLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALR-GGQ--- 1895

Query: 305  VLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGP 364
                             +L I  A+  D G+Y C  +N  G + R+  LTV   P    P
Sbjct: 1896 -----------------RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENP 1938

Query: 365  PVASSSSATSLPWPV---VIGIPAGAV 388
               + S     P  +   V G+PA  V
Sbjct: 1939 KTETVSQVAGSPLVLTCDVSGVPAPTV 1965



 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 88/320 (27%), Positives = 128/320 (40%), Gaps = 61/320 (19%)

Query: 42   RLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKA 101
            RLG  + L+C   G P P   WT + R +  G S  +     L+   V RED+G YVC A
Sbjct: 2950 RLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSE-QDGGSTLQRAAVSREDSGTYVCWA 3008

Query: 102  TNGFG-SLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVI 160
             N  G + +V++  V                    +E P  Q  A              +
Sbjct: 3009 ENRVGRTQAVSFVHV--------------------KEAPVLQGEAFS-----------YL 3037

Query: 161  ARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYT 220
              PVG S++L CV  G P PDI W+KD   L R      + +  +L++     +D+G+Y 
Sbjct: 3038 VEPVGGSIQLDCVVRGDPVPDIHWIKDGLPL-RGSHLRHQLQNGSLTIHRTERDDAGRYQ 3096

Query: 221  CRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQW 280
            C   N  G      K  VI   +S PV     P + TV  G   + +C+   +  P I+W
Sbjct: 3097 CLAENEMGVA----KKVVILVLQSAPVFQ-VEPQDMTVRSGDDVALRCQATGEPTPTIEW 3151

Query: 281  LKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLG 340
            L+  +     R   T          LP G +W            +      DAG Y C+ 
Sbjct: 3152 LQAGQPLRASRRLRT----------LPDGSLW------------LENVETGDAGTYDCVA 3189

Query: 341  ANTMGYSFRSAFLTVLPDPK 360
             N +G +   AFL V  +P+
Sbjct: 3190 HNLLGSATARAFLVVRGEPQ 3209



 Score = 97.1 bits (240), Expect = 3e-20
 Identities = 93/369 (25%), Positives = 160/369 (43%), Gaps = 48/369 (13%)

Query: 20   PPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRV 79
            PP+ +   P  + +  V     ++  T+ L+C     PPP   W KDG+ +    SR +V
Sbjct: 1441 PPSISKDDP--LGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPS-SRLQV 1497

Query: 80   LPQG--LKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQE 137
            L +G  L+++  +  D+G Y+C ATN  G    ++ +++   + P  + +G  S++   E
Sbjct: 1498 LGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI--QVPPMFQKVGDFSAAF--E 1553

Query: 138  DPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAA 197
              + ++ AR   T+     R ++     +   L C  +  P PD+TW ++DQ L+  +  
Sbjct: 1554 ILSREEEARGGVTE----YREIVEN---NPAYLYCDTNAIPPPDLTWYREDQPLSAGDEV 1606

Query: 198  EPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHP---V 254
               +    L +  +R E++G+Y+C+ SN  G     Y++ V+    + PV+ G       
Sbjct: 1607 SVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVL----TPPVILGDTEELVE 1662

Query: 255  NTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSR 314
              TV+   T S QC    +  P I WL+          N        +  VL  G V   
Sbjct: 1663 EVTVNASSTVSLQCPALGNPVPTISWLQ----------NGLPFSPSPRLQVLEDGQV--- 1709

Query: 315  PDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPG----PPVASSS 370
                    L ++ A   DA  Y+C+  N  G + +   L V   P+  G       A  +
Sbjct: 1710 --------LQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILN 1761

Query: 371  SATSLPWPV 379
            S+ SLP  V
Sbjct: 1762 SSVSLPCDV 1770



 Score = 96.3 bits (238), Expect = 6e-20
 Identities = 89/325 (27%), Positives = 132/325 (40%), Gaps = 57/325 (17%)

Query: 28   PPKMADKVVPRQVARL-GRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--L 84
            PP + ++ +   +  L G+T  L C V G P P   W KDGR +  G     + P G  L
Sbjct: 1252 PPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARG-DAHHISPDGVLL 1310

Query: 85   KVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQW 144
            +V Q     AG Y C A N  G  + ++ L VL         L P +  GG ED A ++ 
Sbjct: 1311 QVLQANLSSAGHYSCIAANAVGEKTKHFQLSVL---------LAP-TILGGAEDSADEE- 1359

Query: 145  ARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKW 204
                           +   V + + L C A   P P+ITWMKD          +      
Sbjct: 1360 ---------------VTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTH 1404

Query: 205  TLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVI---QRTRSKPV-LTGTHPVNTTVDF 260
             L + N + ED+G+YTC V+N  G     Y V+V+     ++  P+   G   V T V+ 
Sbjct: 1405 GLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVN- 1463

Query: 261  GGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYL 320
              T + +C+  +   P I+W K                 GQ   V P+  +    +G  L
Sbjct: 1464 -STLTLECESWAVPPPTIRWYK----------------DGQP--VTPSSRLQVLGEGRLL 1504

Query: 321  NKLLITRARQDDAGMYICLGANTMG 345
                I   +  D+G Y+C+  N  G
Sbjct: 1505 Q---IQPTQVSDSGRYLCVATNVAG 1526



 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 87/314 (27%), Positives = 122/314 (38%), Gaps = 61/314 (19%)

Query: 47   VRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKVKQVEREDAGVYVCKATNGF 105
            V L C   G P P   W K+G  + +G S  +VLP G L++     EDAG Y+C A N  
Sbjct: 2774 VLLPCEASGIPRPTITWQKEGLNVATGVST-QVLPGGQLRIAHASPEDAGNYLCIAKNSA 2832

Query: 106  GSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVG 165
            GS      LVV   + P  E+  PD S+                               G
Sbjct: 2833 GSAMGKTRLVV--QVPPVIENGLPDLST-----------------------------TEG 2861

Query: 166  SSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSN 225
            S   L C A G P P+ITW KD Q ++  E     +    L +KNL  +D+G YTC   N
Sbjct: 2862 SHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAEN 2921

Query: 226  RAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVE 285
              G       + ++      PV T T P + ++  G     +C  R    P I W     
Sbjct: 2922 AVGRARRRVHLTIL----VLPVFT-TLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDR 2976

Query: 286  YGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMG 345
               EG                    V  +  GS L +  ++R   +D+G Y+C   N +G
Sbjct: 2977 PVTEG--------------------VSEQDGGSTLQRAAVSR---EDSGTYVCWAENRVG 3013

Query: 346  YSFRSAFLTVLPDP 359
             +   +F+ V   P
Sbjct: 3014 RTQAVSFVHVKEAP 3027



 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 93/335 (27%), Positives = 127/335 (37%), Gaps = 64/335 (19%)

Query: 28   PPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKV 86
            PP +AD      V  +   V L C   G P P   W+K G  + +  S +RV P G L++
Sbjct: 2665 PPTIADDQTDFTVTMMAPVV-LTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEI 2723

Query: 87   KQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWAR 146
             Q     AG Y C A N  G    +  L V                   Q  P       
Sbjct: 2724 GQALPIHAGRYTCSARNSAGVAHKHVFLTV-------------------QASPV------ 2758

Query: 147  PRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTL 206
                +P     R +A      V L C ASG PRP ITW K+   +    + +       L
Sbjct: 2759 ---VKPLPSVVRAVAE---EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQV-LPGGQL 2811

Query: 207  SLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSF 266
             + +  PED+G Y C   N AG+     ++ V    +  PV+    P  +T + G     
Sbjct: 2812 RIAHASPEDAGNYLCIAKNSAGSAMGKTRLVV----QVPPVIENGLPDLSTTE-GSHAFL 2866

Query: 267  QCKVRSDVKPVIQWLK--RVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLL 324
             CK R   +P I W K  +   GAEG           KF + P+G+            LL
Sbjct: 2867 PCKARGSPEPNITWDKDGQPVSGAEG-----------KFTIQPSGE------------LL 2903

Query: 325  ITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP 359
            +      DAG Y C   N +G + R   LT+L  P
Sbjct: 2904 VKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLP 2938



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 80/336 (23%), Positives = 125/336 (37%), Gaps = 57/336 (16%)

Query: 28   PPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLP--QGLK 85
            PP++A   + +  A L  +V L C V   P P   W KD + +  G   F +LP    L+
Sbjct: 1745 PPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVF-LLPGTHTLQ 1803

Query: 86   VKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWA 145
            + +    D+G+Y C+A N  G    +  LV L  + P                       
Sbjct: 1804 LGRARLSDSGMYTCEALNAAGR---DQKLVQLSVLVP----------------------- 1837

Query: 146  RPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWT 205
             P F Q  +  +  +   VG    L C     P P +TW KD Q L   +  +  +    
Sbjct: 1838 -PAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQR 1896

Query: 206  LSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTS 265
            L ++  +  D G Y+C+VSN AG    T+ + V    +  P          +   G    
Sbjct: 1897 LEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTV----QVPPTFENPKTETVSQVAGSPLV 1952

Query: 266  FQCKVRSDVKPVIQWLK-RVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLL 324
              C V     P + WLK R+   +   H   +  GG                     +L 
Sbjct: 1953 LTCDVSGVPAPTVTWLKDRMPVESSAVH-GVVSRGG---------------------RLQ 1990

Query: 325  ITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPK 360
            ++R +   AG Y C+  NT   + +   + VL  P+
Sbjct: 1991 LSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPR 2026



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 86/320 (26%), Positives = 119/320 (37%), Gaps = 60/320 (18%)

Query: 43   LGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKVKQVEREDAGVYVCKA 101
            + +T  L C  +G P PL  W KD   +     RF +LP+G L+++ V  +DAG Y+C A
Sbjct: 2495 VNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLA 2554

Query: 102  TNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIA 161
            +N  GS      L VL+                            P    PS     + A
Sbjct: 2555 SNSAGSDRQGRDLRVLE----------------------------PPAIAPSPSNLTLTA 2586

Query: 162  RPVGSSVRLKCVASGHPRPDITWMKDDQAL--TRPEAAEPRKKKWTLSLKNLRPEDSGKY 219
                +   L C ASG P+P + W KD Q L     + A        L L    P+DS ++
Sbjct: 2587 H---TPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQF 2643

Query: 220  TCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQ 279
             C VSN  G  +  Y+V V       P        + TV         C       P + 
Sbjct: 2644 ECVVSNEVGEAHRLYQVTV-----HVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVS 2698

Query: 280  WLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICL 339
            W K    GA+      +   G  + V P+G             L I +A    AG Y C 
Sbjct: 2699 WSKA---GAQ------LGARGSGYRVSPSG------------ALEIGQALPIHAGRYTCS 2737

Query: 340  GANTMGYSFRSAFLTVLPDP 359
              N+ G + +  FLTV   P
Sbjct: 2738 ARNSAGVAHKHVFLTVQASP 2757



 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 92/378 (24%), Positives = 147/378 (38%), Gaps = 69/378 (18%)

Query: 28   PPKMADKVVPRQVARL-GRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGLKV 86
            PP + D   P +++   G  + L C  +G P P   W KDG+ +    +R     +  +V
Sbjct: 2302 PPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL----TRLENNSRATRV 2357

Query: 87   KQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWAR 146
             +V   DAG+Y C A +  G++  ++ + V                   Q  P       
Sbjct: 2358 LRVR--DAGLYTCLAESPAGAIEKSFRVRV-------------------QAPPNIVGPRG 2396

Query: 147  PRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTL 206
            PRF         V+    G  V L+C     P P ITW +D   L      +  ++   L
Sbjct: 2397 PRF---------VVGLAPGQLV-LECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFL 2446

Query: 207  SLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVL-TGTHPVNTTVDFGGTTS 265
             L+ L   DSG Y+C   N AG+ +  ++V++     + P + +G   VN +V+   T  
Sbjct: 2447 QLQALSTADSGDYSCTARNAAGSTSVAFRVEI----HTVPTIRSGPPAVNVSVN--QTAL 2500

Query: 266  FQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLI 325
              C+      P++ W K             +D    +F +LP G +  +P          
Sbjct: 2501 LPCQADGVPAPLVSWRK---------DRVPLDPRSPRFEILPEGSLRIQP---------- 2541

Query: 326  TRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIPA 385
                  DAG Y+CL +N+ G   +   L VL       P +A S S  +L       +P 
Sbjct: 2542 --VLAQDAGHYLCLASNSAGSDRQGRDLRVLEP-----PAIAPSPSNLTLTAHTPALLPC 2594

Query: 386  GAVFILGTLLLWLCQAQK 403
             A      L++W    QK
Sbjct: 2595 EASGSPKPLVVWWKDGQK 2612



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 95/370 (25%), Positives = 143/370 (38%), Gaps = 77/370 (20%)

Query: 28   PPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--LK 85
            PP +    V + V     +V L+C   G PPP   W K  + + S W    V   G  L+
Sbjct: 694  PPNIEPGPVNKAVLE-NASVTLECLASGVPPPDVSWFKGHQPV-SSWMGVTVSVDGRVLR 751

Query: 86   VKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWA 145
            ++Q +  DAG Y C A+N  GS  + Y L V                             
Sbjct: 752  IEQAQLSDAGSYRCVASNVAGSTELRYGLRVN---------------------------V 784

Query: 146  RPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKW- 204
             PR T P  +   V+   V + VRL C A+G P P + W+KD   ++   A  P  + + 
Sbjct: 785  PPRITLPPSLPGPVL---VNTPVRLTCNATGAPSPTLMWLKDGNPVS--PAGTPGLQVFP 839

Query: 205  ---TLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFG 261
                L+L + R  DSG+Y+C   +  G      + DV+ +    P + G   +N +V   
Sbjct: 840  GGRVLTLASARASDSGRYSCVAVSAVG----EDRQDVVLQVHMPPSILG-EELNVSVVAN 894

Query: 262  GTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLN 321
             + + +C+  +   PV+ W K      +GR             + P   V    D + L 
Sbjct: 895  ESVALECQSHAMPPPVLSWWK------DGR------------PLEPRPGVHLSADKALLQ 936

Query: 322  KLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPP-----------GPPVASSS 370
               + RA   DAG Y C   N  G S +   L V   P  P           G P + S 
Sbjct: 937  ---VDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSC 993

Query: 371  SATSLPWPVV 380
                +P+P +
Sbjct: 994  ECRGVPFPKI 1003



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 84/355 (23%), Positives = 132/355 (37%), Gaps = 67/355 (18%)

Query: 7    LLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKD 66
            L +L+PP L+G   P              +    A L   + L C   G PPP   W + 
Sbjct: 1153 LSVLVPPELIGDLDP--------------LTNITAALHSPLTLLCEAMGIPPPAIRWFRG 1198

Query: 67   GRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGK 124
               +  G   + +L  G  LK+ Q + +D+G+Y C A+N  G    N+++ VL   S   
Sbjct: 1199 EEPVSPGEDTY-LLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIEN 1257

Query: 125  ESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITW 184
            E L                               VI    G +  L C  +GHP+P +TW
Sbjct: 1258 EDL-----------------------------EEVIKVLDGQTAHLMCNVTGHPQPKLTW 1288

Query: 185  MKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRS 244
             KD + L R +A         L +       +G Y+C  +N  G     +++ V+     
Sbjct: 1289 FKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTI 1348

Query: 245  KPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFV 304
                  +     TV      S  C+  +   P I W+K    GA    +  I        
Sbjct: 1349 LGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKD---GAPFEASRNIQ------- 1398

Query: 305  VLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP 359
            +LP             + L I  A+++DAG Y C+  N +G + ++  + VL  P
Sbjct: 1399 LLPG-----------THGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPP 1442



 Score = 83.6 bits (205), Expect = 4e-16
 Identities = 84/359 (23%), Positives = 133/359 (37%), Gaps = 69/359 (19%)

Query: 49   LQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCKATNGFG 106
            L C     PPP   W ++ + + +G     VL  G  L++  V  E+AG Y CKA+N  G
Sbjct: 1579 LYCDTNAIPPPDLTWYREDQPLSAG-DEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVG 1637

Query: 107  SLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGS 166
               ++Y L+VL           P    G  E+   +                 +     S
Sbjct: 1638 EDWLHYELLVLT----------PPVILGDTEELVEE-----------------VTVNASS 1670

Query: 167  SVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNR 226
            +V L+C A G+P P I+W+++    +     +  +    L +      D+  Y C   N+
Sbjct: 1671 TVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQ 1730

Query: 227  AGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEY 286
            AG+    + +    R +  P + G      T     + S  C V +   P + W K    
Sbjct: 1731 AGSAEKLFTL----RVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYK---- 1782

Query: 287  GAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGY 346
                  +  + +G + F++  T            + L + RAR  D+GMY C   N  G 
Sbjct: 1783 -----DSQALSLGEEVFLLPGT------------HTLQLGRARLSDSGMYTCEALNAAGR 1825

Query: 347  SFRSAFLTVLPDP----KPPGPPVA----------SSSSATSLPWPVVIGIPAGAVFIL 391
              +   L+VL  P     P GP  A           S    +LP P V     G   +L
Sbjct: 1826 DQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVL 1884



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 102/410 (24%), Positives = 149/410 (36%), Gaps = 85/410 (20%)

Query: 20   PPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWS-RFR 78
            P  A  R PP     VV   VA L      +C   G PPP   W +DG+ + +    + +
Sbjct: 1065 PQIAGPREPPTQVS-VVQDGVATL------ECNATGKPPPTVTWERDGQPVGAELGLQLQ 1117

Query: 79   VLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQED 138
               Q L V++ +    G Y C A N  G     + L VL         + P+    G  D
Sbjct: 1118 NQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVL---------VPPELI--GDLD 1166

Query: 139  PASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAE 198
            P +                  I   + S + L C A G P P I W + ++ ++  E   
Sbjct: 1167 PLTN-----------------ITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTY 1209

Query: 199  PRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTV 258
                 W L +   + +DSG Y+C  SN AG     + V+V+     +        V   +
Sbjct: 1210 LLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIEN--EDLEEVIKVL 1267

Query: 259  DFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWS-RPDG 317
            D G T    C V    +P + W K      +GR              L  GD     PDG
Sbjct: 1268 D-GQTAHLMCNVTGHPQPKLTWFK------DGR-------------PLARGDAHHISPDG 1307

Query: 318  SYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPG-------------- 363
              L    + +A    AG Y C+ AN +G   +   L+VL  P   G              
Sbjct: 1308 VLLQ---VLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTV 1364

Query: 364  -PPVASSSSATSLPWPVVIGIPAGAVF--------ILGTLLLWLCQAQKK 404
              P++    A + P P +  +  GA F        + GT  L +  AQK+
Sbjct: 1365 NNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKE 1414



 Score = 79.3 bits (194), Expect = 7e-15
 Identities = 74/282 (26%), Positives = 106/282 (37%), Gaps = 58/282 (20%)

Query: 80  LPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDP 139
           LP  L++++V+  D G+Y C ATN  G       L VL                      
Sbjct: 655 LPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLV--------------------- 693

Query: 140 ASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEP 199
                  P   +P  + + V+     +SV L+C+ASG P PD++W K  Q ++       
Sbjct: 694 -------PPNIEPGPVNKAVLEN---ASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTV 743

Query: 200 RKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATY--KVDVIQRTRSKPVLTGTHPVNTT 257
                 L ++  +  D+G Y C  SN AG+    Y  +V+V  R    P L G   VNT 
Sbjct: 744 SVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTP 803

Query: 258 VDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDG 317
           V         C       P + WLK      +G  N     G     V P G V      
Sbjct: 804 V------RLTCNATGAPSPTLMWLK------DG--NPVSPAGTPGLQVFPGGRV------ 843

Query: 318 SYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP 359
                L +  AR  D+G Y C+  + +G   +   L V   P
Sbjct: 844 -----LTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPP 880



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 81/329 (24%), Positives = 124/329 (37%), Gaps = 71/329 (21%)

Query: 40   VARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG----LKVKQVEREDAG 95
            V+R G  V + CPV G PP    W KDG  +       R L  G    L++ +V+  DAG
Sbjct: 2133 VSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQ---RTLLHGSGHTLRISKVQLADAG 2189

Query: 96   VYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKM 155
            ++ C A +  G    N+TL V                              P   +P + 
Sbjct: 2190 IFTCVAASPAGVADRNFTLQV----------------------------QVPPVLEPVEF 2221

Query: 156  RRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPED 215
            +  V+    GS V L C A G P P ++WMKD +    P  ++  ++  +L L+ +   D
Sbjct: 2222 QNDVVVVR-GSLVELPCEARGVPLPLVSWMKDGE----PLLSQSLEQGPSLQLEAVGAGD 2276

Query: 216  SGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVK 275
            SG Y+C   + AG     +++ V++      +     P   ++  G      C  +   +
Sbjct: 2277 SGTYSCVAVSEAGEARRHFQLTVMEPPH---IEDSGQPTELSLTPGAPMELLCDAQGTPQ 2333

Query: 276  PVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGM 335
            P I W K                 GQ    L      +R          + R R  DAG+
Sbjct: 2334 PNITWHK----------------DGQALTRLENNSRATR----------VLRVR--DAGL 2365

Query: 336  YICLGANTMGYSFRSAFLTVLPDPKPPGP 364
            Y CL  +  G   +S  + V   P   GP
Sbjct: 2366 YTCLAESPAGAIEKSFRVRVQAPPNIVGP 2394



 Score = 77.0 bits (188), Expect = 4e-14
 Identities = 82/351 (23%), Positives = 125/351 (35%), Gaps = 73/351 (20%)

Query: 44   GRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWS---RFRVLPQGLKVKQVEREDAGVYVCK 100
            G+ VRL C  +G PPP   W KDG  +        RF +    L +K +   DAG Y C 
Sbjct: 2041 GQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCV 2100

Query: 101  ATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVI 160
            A N  G  +  +T+ VL    P     G D S                          ++
Sbjct: 2101 AHNPAGEDARLHTVNVL---VPPTIKQGADGSG------------------------TLV 2133

Query: 161  ARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYT 220
            +RP G  V + C   G P   ++W+KD   L   +         TL +  ++  D+G +T
Sbjct: 2134 SRP-GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFT 2192

Query: 221  CRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDF-GGTTSFQCKVRSDVKPVIQ 279
            C  ++ AG  +  + + V    +  PVL      N  V   G      C+ R    P++ 
Sbjct: 2193 CVAASPAGVADRNFTLQV----QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVS 2248

Query: 280  WLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICL 339
            W+K      E   + +++ G                       L +      D+G Y C+
Sbjct: 2249 WMK----DGEPLLSQSLEQG---------------------PSLQLEAVGAGDSGTYSCV 2283

Query: 340  GANTMGYSFRSAFLTVLPDPK------------PPGPPVASSSSATSLPWP 378
              +  G + R   LTV+  P              PG P+     A   P P
Sbjct: 2284 AVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQP 2334



 Score = 75.9 bits (185), Expect = 8e-14
 Identities = 74/323 (22%), Positives = 124/323 (38%), Gaps = 58/323 (17%)

Query: 42   RLGRTVRLQCPVEGDPPPLTMWTKDGRTIH---SGWSRFRVLPQGLKVKQVEREDAGVYV 98
            R G    L C   G P P   W KDG+ +    +G      + + L + Q +    G Y 
Sbjct: 984  REGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYT 1043

Query: 99   CKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRR 158
            C+ +N  G+ S +  L          E   P   +G +E P          TQ S ++  
Sbjct: 1044 CECSNVVGNSSQDLQL----------EVHVPPQIAGPREPP----------TQVSVVQDG 1083

Query: 159  VIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGK 218
            V          L+C A+G P P +TW +D Q +      + + +  +L ++  +   +G+
Sbjct: 1084 VAT--------LECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGR 1135

Query: 219  YTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHP--VNTTVDFGGTTSFQCKVRSDVKP 276
            Y+C   N AG     +++ V+      P L G      N T       +  C+      P
Sbjct: 1136 YSCVAENLAGRAERKFELSVL----VPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPP 1191

Query: 277  VIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMY 336
             I+W +  E  + G     +  G            W          L +T+ ++ D+G+Y
Sbjct: 1192 AIRWFRGEEPVSPGEDTYLLAGG------------W---------MLKMTQTQEQDSGLY 1230

Query: 337  ICLGANTMGYSFRSAFLTVLPDP 359
             CL +N  G + R+  + VL  P
Sbjct: 1231 SCLASNEAGEARRNFSVEVLVPP 1253



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 98/410 (23%), Positives = 147/410 (35%), Gaps = 69/410 (16%)

Query: 43  LGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCK 100
           +G+ + L C   G P P   W ++GR      +  +V  QG  L +  VE + +G++ C+
Sbjct: 512 VGQPLELPCQASGSPVPTIQWLQNGRPAEE-LAGVQVASQGTTLHIDHVELDHSGLFACQ 570

Query: 101 ATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVI 160
           ATN  G+      + V  + +PG   +       G E  +S     P    P       +
Sbjct: 571 ATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSF----PAACDPP------V 620

Query: 161 ARPVGSSVRLKCVASGHPRPDIT--WMKDDQALTRPEAAEPRKK-KWTLSLKNLRPEDSG 217
            R  G+          HP+P +   W         P            L ++ +   D G
Sbjct: 621 HRGWGA----------HPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEG 670

Query: 218 KYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPV 277
            YTC  +N AG       + V+     +P      PVN  V    + + +C       P 
Sbjct: 671 IYTCAATNLAGESKREVALKVLVPPNIEP-----GPVNKAVLENASVTLECLASGVPPPD 725

Query: 278 IQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYI 337
           + W K  +         T+ V G+                     L I +A+  DAG Y 
Sbjct: 726 VSWFKGHQ-PVSSWMGVTVSVDGRV--------------------LRIEQAQLSDAGSYR 764

Query: 338 CLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIP----AGAVFILGT 393
           C+ +N  G +     L V   P+   PP        SLP PV++  P      A      
Sbjct: 765 CVASNVAGSTELRYGLRVNVPPRITLPP--------SLPGPVLVNTPVRLTCNATGAPSP 816

Query: 394 LLLWLCQAQKKPCTPAPAPPL---PGHRPPGTARDRSGDKDLPSLAALSA 440
            L+WL      P +PA  P L   PG R    A  R+ D    S  A+SA
Sbjct: 817 TLMWL--KDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSA 864



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 78/302 (25%), Positives = 110/302 (36%), Gaps = 57/302 (18%)

Query: 47  VRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG---LKVKQVEREDAGVYVCKATN 103
           V+L C   G P P   W KDG  + +  S   V  +G   L++ + +  DAGVY CKA+N
Sbjct: 329 VQLLCEARGVPTPNITWFKDGALLPT--STKVVYTRGGRQLQLGRAQSSDAGVYTCKASN 386

Query: 104 GFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARP 163
             G+      L V   + P  E  G                           R  V+   
Sbjct: 387 AVGAAEKATRLDVY--VPPTIEGAGG--------------------------RPYVVKAV 418

Query: 164 VGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRV 223
            G  V L+CVA GHP P ++W  +   +     +        L L++     SG Y+C  
Sbjct: 419 AGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVA 478

Query: 224 SNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKR 283
           S+ AG     Y V+V Q      V  G   V T V  G      C+      P IQWL+ 
Sbjct: 479 SSPAGEAVLQYSVEV-QVPPQLLVAEGLGQVTTIV--GQPLELPCQASGSPVPTIQWLQN 535

Query: 284 VEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANT 343
              G      + + V  Q               G+ L+   I     D +G++ C   N 
Sbjct: 536 ---GRPAEELAGVQVASQ---------------GTTLH---IDHVELDHSGLFACQATNE 574

Query: 344 MG 345
            G
Sbjct: 575 AG 576



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 93/392 (23%), Positives = 134/392 (34%), Gaps = 78/392 (19%)

Query: 20  PPAAAARGPPKMADKVVPRQVARL-GRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFR 78
           P A +   PP +      ++V  L G  V LQC   G P P   WTKD + +  G    +
Sbjct: 207 PHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQ 266

Query: 79  VLPQG--LKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQ 136
           V   G  L++      D G Y C A +  G  + ++ L V            P +  G  
Sbjct: 267 VQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRV----------HAPPTIWGSN 316

Query: 137 EDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEA 196
           E                      +A      V+L C A G P P+ITW KD   L     
Sbjct: 317 ETGE-------------------VAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTK 357

Query: 197 AEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGT--HPV 254
               +    L L   +  D+G YTC+ SN  GA     ++DV       P + G    P 
Sbjct: 358 VVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY----VPPTIEGAGGRPY 413

Query: 255 NTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSR 314
                 G   + +C  R    P + W           H+  + V       L T      
Sbjct: 414 VVKAVAGRPVALECVARGHPSPTLSW-----------HHEGLPVAESNESRLET------ 456

Query: 315 PDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATS 374
            DGS L    +    +  +G+Y C+ ++                  P G  V   S    
Sbjct: 457 -DGSVLR---LESPGEASSGLYSCVASS------------------PAGEAVLQYSVEVQ 494

Query: 375 LPWPVVIGIPAGAV-FILGTLLLWLCQAQKKP 405
           +P  +++    G V  I+G  L   CQA   P
Sbjct: 495 VPPQLLVAEGLGQVTTIVGQPLELPCQASGSP 526



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 91/402 (22%), Positives = 144/402 (35%), Gaps = 90/402 (22%)

Query: 7    LLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKD 66
            L +LL P +LG         G    AD+ V      +   + L C     P P   W KD
Sbjct: 1340 LSVLLAPTILG---------GAEDSADEEV---TVTVNNPISLICEALAFPSPNITWMKD 1387

Query: 67   GRTIHSGWSRFRVLP--QGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGK 124
            G    +     ++LP   GL++   ++EDAG Y C  TN  G    NY + VL  I P  
Sbjct: 1388 GAPFEAS-RNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVL--IPP-- 1442

Query: 125  ESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITW 184
                    S  ++DP  +   +             +   V S++ L+C +   P P I W
Sbjct: 1443 --------SISKDDPLGEVGVKE------------VKTKVNSTLTLECESWAVPPPTIRW 1482

Query: 185  MKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRS 244
             KD Q +T     +   +   L ++  +  DSG+Y C  +N AG  +  + V +    + 
Sbjct: 1483 YKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI----QV 1538

Query: 245  KPVLTGTHPVNTTVDF--------GGTTSFQ-----------CKVRSDVKPVIQWLKRVE 285
             P+       +   +         GG T ++           C   +   P + W +  +
Sbjct: 1539 PPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQ 1598

Query: 286  YGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMG 345
              + G   S +  G                       L I   R ++AG Y C  +N +G
Sbjct: 1599 PLSAGDEVSVLQGG---------------------RVLQIPLVRAENAGRYSCKASNEVG 1637

Query: 346  YSFRSAFLTVLPDPKPPGPP-------VASSSSATSLPWPVV 380
              +    L VL  P   G           ++SS  SL  P +
Sbjct: 1638 EDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPAL 1679



 Score = 69.3 bits (168), Expect = 8e-12
 Identities = 82/321 (25%), Positives = 112/321 (34%), Gaps = 57/321 (17%)

Query: 47   VRLQCPVEGDPPPLTMWTKDGRTIH-SGWSRFRVLPQG--LKVKQVEREDAGVYVCKATN 103
            VRL C   G P P  MW KDG  +  +G    +V P G  L +      D+G Y C A +
Sbjct: 804  VRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVS 863

Query: 104  GFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARP 163
              G    +  L V            P S  G                   ++   V+A  
Sbjct: 864  AVGEDRQDVVLQVHM----------PPSILG------------------EELNVSVVAN- 894

Query: 164  VGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRV 223
               SV L+C +   P P ++W KD + L           K  L +      D+G YTC  
Sbjct: 895  --ESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEA 952

Query: 224  SNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKR 283
             N+AG     Y ++V       PV         TV  G  TS  C+ R    P I W K 
Sbjct: 953  LNQAGRSEKHYNLNV----WVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRK- 1007

Query: 284  VEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANT 343
                            GQ    LP      +   +    L + +A+    G Y C  +N 
Sbjct: 1008 ---------------DGQP---LPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNV 1049

Query: 344  MGYSFRSAFLTVLPDPKPPGP 364
            +G S +   L V   P+  GP
Sbjct: 1050 VGNSSQDLQLEVHVPPQIAGP 1070



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 75/341 (21%), Positives = 127/341 (37%), Gaps = 65/341 (19%)

Query: 44  GRTVRLQCPVEGDPPPLTMWTKDGRTIHS--GWSRF------------RVLPQGLKVKQV 89
           G+++ L+C   G P P  +W KD + +    GW+ +            R+L +G  +   
Sbjct: 111 GQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSL-HF 169

Query: 90  EREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRF 149
            R   G    +     GS             +P    L     +G ++ P    ++ P  
Sbjct: 170 PRIQPGRSGRRGAQAGGSAQTK---------APWXAGL-----AGFEQFPTPHAFSPP-- 213

Query: 150 TQPSKM---RRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQ-ALTRPEAAEPRKKKWT 205
             PS +     + +    G+ V L+C  SG P P + W KD Q  L      + ++    
Sbjct: 214 APPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQV 273

Query: 206 LSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPV-NTTVDFGGTT 264
           L +      D G+Y C   + AG     +++    R  + P + G++      V      
Sbjct: 274 LRITGSHVGDEGRYQCVAFSPAGQQARDFQL----RVHAPPTIWGSNETGEVAVMEDHLV 329

Query: 265 SFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGD--VWSRPDGSYLNK 322
              C+ R    P I W K      +G              +LPT    V++R       +
Sbjct: 330 QLLCEARGVPTPNITWFK------DG-------------ALLPTSTKVVYTRGG----RQ 366

Query: 323 LLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPG 363
           L + RA+  DAG+Y C  +N +G + ++  L V   P   G
Sbjct: 367 LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEG 407



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 43/147 (29%), Positives = 58/147 (39%), Gaps = 33/147 (22%)

Query: 51  CPVEGDPPPLTMWTK--DGRTIHSGWSRFRVLPQG-LKVKQVEREDAGVYVCKATNGFGS 107
           C   G P P   W K      +H G     VL +G L +  V   D+G Y C+ATN  GS
Sbjct: 24  CGTHGTPKPQVTWRKGPSSEPLH-GQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGS 82

Query: 108 LSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSS 167
            S    LVV   + P     G                           R+  ++   G S
Sbjct: 83  TSRRAKLVVY--VPPSIREDG---------------------------RKANVSGMAGQS 113

Query: 168 VRLKCVASGHPRPDITWMKDDQALTRP 194
           + L+C A+G P P+I W+KD Q +  P
Sbjct: 114 LTLECDANGFPVPEIVWLKDAQLVGVP 140



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 29/114 (25%), Positives = 48/114 (42%), Gaps = 8/114 (7%)

Query: 172 CVASGHPRPDITWMKDDQALTRPEAAEPRK---KKWTLSLKNLRPEDSGKYTCRVSNRAG 228
           C   G P+P +TW K   +   P   +P     ++ +L L ++ P DSG Y C+ +N  G
Sbjct: 24  CGTHGTPKPQVTWRKGPSS--EPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVG 81

Query: 229 AINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLK 282
           + +   K+ V        +       N +   G + + +C       P I WLK
Sbjct: 82  STSRRAKLVVYV---PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLK 132


>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 5065

 Score =  107 bits (267), Expect = 3e-23
 Identities = 105/375 (28%), Positives = 137/375 (36%), Gaps = 82/375 (21%)

Query: 29   PKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKVK 87
            P + +  +P      G    L C   G P P   W KDG+ +     +F + P G L VK
Sbjct: 4037 PPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVK 4096

Query: 88   QVEREDAGVYVCKATNGFGSL--SVNYTLVVLDDIS--PGKESLGPDSSSGGQEDPASQQ 143
             +E +DAG Y C A N  G     V+ T++VL   +  PG  SL                
Sbjct: 4097 NLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSL---------------- 4140

Query: 144  WARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKK 203
                                +G  + L+C A G P P I W  +D+ +T  E    +   
Sbjct: 4141 -------------------RLGDRLWLRCAARGSPTPRIGWTVNDRPVT--EGVSEQDGG 4179

Query: 204  WTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGT 263
             TL    +  EDSG Y C   NR G   A   V V    +  PVL G          GG+
Sbjct: 4180 STLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHV----KEAPVLQGEAFSYLVEPVGGS 4235

Query: 264  TSFQCKVRSDVKPVIQWLK--RVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLN 321
                C VR D  P I W+K      G+  RH             L  G            
Sbjct: 4236 IQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQ------------LQNG------------ 4271

Query: 322  KLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP----KP------PGPPVASSSS 371
             L I R  +DDAG Y CL  N MG + +   L +   P    +P       G  VA    
Sbjct: 4272 SLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQ 4331

Query: 372  ATSLPWPVVIGIPAG 386
            AT  P P +  + AG
Sbjct: 4332 ATGEPTPTIEWLQAG 4346



 Score =  102 bits (255), Expect = 6e-22
 Identities = 102/387 (26%), Positives = 142/387 (36%), Gaps = 71/387 (18%)

Query: 7    LLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKD 66
            LL+L PP++LG               +++V         TV LQCP  G+P P   W ++
Sbjct: 2836 LLVLTPPVILGD-------------TEELVEEVTVNASSTVSLQCPALGNPVPTISWLQN 2882

Query: 67   GRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGK 124
            G    S   R +VL  G  L+V   E  DA  Y+C A N  GS    +TL V   + P  
Sbjct: 2883 GLPF-SPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRV--QVPPRI 2939

Query: 125  ESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITW 184
              L  +                             +   + SSV L C    HP P++TW
Sbjct: 2940 AGLDLEQ----------------------------VTAILNSSVSLPCDVHAHPNPEVTW 2971

Query: 185  MKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRS 244
             KD QAL+  E         TL L   R  DSG YTC   N AG      ++ V+     
Sbjct: 2972 YKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAF 3031

Query: 245  KPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFV 304
            +    G       V  G      C+  +  +P + W K  +     +    +  GGQ   
Sbjct: 3032 RQAPRGPQDA-VLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALR-GGQ--- 3086

Query: 305  VLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGP 364
                             +L I  A+  D G+Y C  +N  G + R+  LTV   P    P
Sbjct: 3087 -----------------RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENP 3129

Query: 365  PVASSSSATSLPWPV---VIGIPAGAV 388
               + S     P  +   V G+PA  V
Sbjct: 3130 KTETVSQVAGSPLVLTCDVSGVPAPTV 3156



 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 88/320 (27%), Positives = 128/320 (40%), Gaps = 61/320 (19%)

Query: 42   RLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKA 101
            RLG  + L+C   G P P   WT + R +  G S  +     L+   V RED+G YVC A
Sbjct: 4141 RLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSE-QDGGSTLQRAAVSREDSGTYVCWA 4199

Query: 102  TNGFG-SLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVI 160
             N  G + +V++  V                    +E P  Q  A              +
Sbjct: 4200 ENRVGRTQAVSFVHV--------------------KEAPVLQGEAFS-----------YL 4228

Query: 161  ARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYT 220
              PVG S++L CV  G P PDI W+KD   L R      + +  +L++     +D+G+Y 
Sbjct: 4229 VEPVGGSIQLDCVVRGDPVPDIHWIKDGLPL-RGSHLRHQLQNGSLTIHRTERDDAGRYQ 4287

Query: 221  CRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQW 280
            C   N  G      K  VI   +S PV     P + TV  G   + +C+   +  P I+W
Sbjct: 4288 CLAENEMGVA----KKVVILVLQSAPVFQ-VEPQDMTVRSGDDVALRCQATGEPTPTIEW 4342

Query: 281  LKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLG 340
            L+  +     R   T          LP G +W            +      DAG Y C+ 
Sbjct: 4343 LQAGQPLRASRRLRT----------LPDGSLW------------LENVETGDAGTYDCVA 4380

Query: 341  ANTMGYSFRSAFLTVLPDPK 360
             N +G +   AFL V  +P+
Sbjct: 4381 HNLLGSATARAFLVVRGEPQ 4400



 Score = 97.1 bits (240), Expect = 3e-20
 Identities = 93/369 (25%), Positives = 160/369 (43%), Gaps = 48/369 (13%)

Query: 20   PPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRV 79
            PP+ +   P  + +  V     ++  T+ L+C     PPP   W KDG+ +    SR +V
Sbjct: 2632 PPSISKDDP--LGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPS-SRLQV 2688

Query: 80   LPQG--LKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQE 137
            L +G  L+++  +  D+G Y+C ATN  G    ++ +++   + P  + +G  S++   E
Sbjct: 2689 LGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI--QVPPMFQKVGDFSAAF--E 2744

Query: 138  DPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAA 197
              + ++ AR   T+     R ++     +   L C  +  P PD+TW ++DQ L+  +  
Sbjct: 2745 ILSREEEARGGVTE----YREIVEN---NPAYLYCDTNAIPPPDLTWYREDQPLSAGDEV 2797

Query: 198  EPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHP---V 254
               +    L +  +R E++G+Y+C+ SN  G     Y++ V+    + PV+ G       
Sbjct: 2798 SVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVL----TPPVILGDTEELVE 2853

Query: 255  NTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSR 314
              TV+   T S QC    +  P I WL+          N        +  VL  G V   
Sbjct: 2854 EVTVNASSTVSLQCPALGNPVPTISWLQ----------NGLPFSPSPRLQVLEDGQV--- 2900

Query: 315  PDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPG----PPVASSS 370
                    L ++ A   DA  Y+C+  N  G + +   L V   P+  G       A  +
Sbjct: 2901 --------LQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILN 2952

Query: 371  SATSLPWPV 379
            S+ SLP  V
Sbjct: 2953 SSVSLPCDV 2961



 Score = 96.3 bits (238), Expect = 6e-20
 Identities = 89/325 (27%), Positives = 132/325 (40%), Gaps = 57/325 (17%)

Query: 28   PPKMADKVVPRQVARL-GRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--L 84
            PP + ++ +   +  L G+T  L C V G P P   W KDGR +  G     + P G  L
Sbjct: 2443 PPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARG-DAHHISPDGVLL 2501

Query: 85   KVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQW 144
            +V Q     AG Y C A N  G  + ++ L VL         L P +  GG ED A ++ 
Sbjct: 2502 QVLQANLSSAGHYSCIAANAVGEKTKHFQLSVL---------LAP-TILGGAEDSADEE- 2550

Query: 145  ARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKW 204
                           +   V + + L C A   P P+ITWMKD          +      
Sbjct: 2551 ---------------VTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTH 2595

Query: 205  TLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVI---QRTRSKPV-LTGTHPVNTTVDF 260
             L + N + ED+G+YTC V+N  G     Y V+V+     ++  P+   G   V T V+ 
Sbjct: 2596 GLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVN- 2654

Query: 261  GGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYL 320
              T + +C+  +   P I+W K                 GQ   V P+  +    +G  L
Sbjct: 2655 -STLTLECESWAVPPPTIRWYK----------------DGQP--VTPSSRLQVLGEGRLL 2695

Query: 321  NKLLITRARQDDAGMYICLGANTMG 345
                I   +  D+G Y+C+  N  G
Sbjct: 2696 Q---IQPTQVSDSGRYLCVATNVAG 2717



 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 87/314 (27%), Positives = 122/314 (38%), Gaps = 61/314 (19%)

Query: 47   VRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKVKQVEREDAGVYVCKATNGF 105
            V L C   G P P   W K+G  + +G S  +VLP G L++     EDAG Y+C A N  
Sbjct: 3965 VLLPCEASGIPRPTITWQKEGLNVATGVST-QVLPGGQLRIAHASPEDAGNYLCIAKNSA 4023

Query: 106  GSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVG 165
            GS      LVV   + P  E+  PD S+                               G
Sbjct: 4024 GSAMGKTRLVV--QVPPVIENGLPDLST-----------------------------TEG 4052

Query: 166  SSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSN 225
            S   L C A G P P+ITW KD Q ++  E     +    L +KNL  +D+G YTC   N
Sbjct: 4053 SHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAEN 4112

Query: 226  RAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVE 285
              G       + ++      PV T T P + ++  G     +C  R    P I W     
Sbjct: 4113 AVGRARRRVHLTIL----VLPVFT-TLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDR 4167

Query: 286  YGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMG 345
               EG                    V  +  GS L +  ++R   +D+G Y+C   N +G
Sbjct: 4168 PVTEG--------------------VSEQDGGSTLQRAAVSR---EDSGTYVCWAENRVG 4204

Query: 346  YSFRSAFLTVLPDP 359
             +   +F+ V   P
Sbjct: 4205 RTQAVSFVHVKEAP 4218



 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 93/335 (27%), Positives = 127/335 (37%), Gaps = 64/335 (19%)

Query: 28   PPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKV 86
            PP +AD      V  +   V L C   G P P   W+K G  + +  S +RV P G L++
Sbjct: 3856 PPTIADDQTDFTVTMMAPVV-LTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEI 3914

Query: 87   KQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWAR 146
             Q     AG Y C A N  G    +  L V                   Q  P       
Sbjct: 3915 GQALPIHAGRYTCSARNSAGVAHKHVFLTV-------------------QASPV------ 3949

Query: 147  PRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTL 206
                +P     R +A      V L C ASG PRP ITW K+   +    + +       L
Sbjct: 3950 ---VKPLPSVVRAVAE---EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQV-LPGGQL 4002

Query: 207  SLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSF 266
             + +  PED+G Y C   N AG+     ++ V    +  PV+    P  +T + G     
Sbjct: 4003 RIAHASPEDAGNYLCIAKNSAGSAMGKTRLVV----QVPPVIENGLPDLSTTE-GSHAFL 4057

Query: 267  QCKVRSDVKPVIQWLK--RVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLL 324
             CK R   +P I W K  +   GAEG           KF + P+G+            LL
Sbjct: 4058 PCKARGSPEPNITWDKDGQPVSGAEG-----------KFTIQPSGE------------LL 4094

Query: 325  ITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP 359
            +      DAG Y C   N +G + R   LT+L  P
Sbjct: 4095 VKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLP 4129



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 94/360 (26%), Positives = 138/360 (38%), Gaps = 63/360 (17%)

Query: 28   PPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKV 86
            PP++        +   G    L C   G P P   WTK+   + S    + V  +G L +
Sbjct: 975  PPRI-HPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLI 1033

Query: 87   KQVEREDAGVYVCKATN--GFGS----LSVN-----------YTLVVLDDISPGKESLGP 129
             Q   +DAG YVC ATN  GF S    LSVN           Y L+    +   +  +G 
Sbjct: 1034 AQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGD 1093

Query: 130  ----DSSSGGQEDPASQQWAR----PRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPD 181
                + ++      AS ++      P   QP     RV+   VG ++ L CVA G+P P 
Sbjct: 1094 SGHYECTASNPAGSASHRYVLGVQVPPQVQPGP---RVLKVLVGEALDLNCVAEGNPEPQ 1150

Query: 182  ITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQR 241
            ++W KD   L      + R  + ++    +R  D+G+Y C  SN AG      ++ V++ 
Sbjct: 1151 LSWSKDGVVL------QGRGPQGSVHFAAIRTSDAGRYRCEASNSAGVDAWEVELRVLE- 1203

Query: 242  TRSKPVLTGTHPVNTTVD--FGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVG 299
                P   G    +  ++   G   S  C  R   KP + W K     +E  H      G
Sbjct: 1204 ----PPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGP--SSEPLH------G 1251

Query: 300  GQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP 359
                 VL  G             L +      D+G Y C   N +G + R A L V   P
Sbjct: 1252 QPGVAVLEEG------------SLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPP 1299



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 80/336 (23%), Positives = 125/336 (37%), Gaps = 57/336 (16%)

Query: 28   PPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLP--QGLK 85
            PP++A   + +  A L  +V L C V   P P   W KD + +  G   F +LP    L+
Sbjct: 2936 PPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVF-LLPGTHTLQ 2994

Query: 86   VKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWA 145
            + +    D+G+Y C+A N  G    +  LV L  + P                       
Sbjct: 2995 LGRARLSDSGMYTCEALNAAGR---DQKLVQLSVLVP----------------------- 3028

Query: 146  RPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWT 205
             P F Q  +  +  +   VG    L C     P P +TW KD Q L   +  +  +    
Sbjct: 3029 -PAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQR 3087

Query: 206  LSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTS 265
            L ++  +  D G Y+C+VSN AG    T+ + V    +  P          +   G    
Sbjct: 3088 LEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTV----QVPPTFENPKTETVSQVAGSPLV 3143

Query: 266  FQCKVRSDVKPVIQWLK-RVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLL 324
              C V     P + WLK R+   +   H   +  GG                     +L 
Sbjct: 3144 LTCDVSGVPAPTVTWLKDRMPVESSAVH-GVVSRGG---------------------RLQ 3181

Query: 325  ITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPK 360
            ++R +   AG Y C+  NT   + +   + VL  P+
Sbjct: 3182 LSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPR 3217



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 86/320 (26%), Positives = 119/320 (37%), Gaps = 60/320 (18%)

Query: 43   LGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKVKQVEREDAGVYVCKA 101
            + +T  L C  +G P PL  W KD   +     RF +LP+G L+++ V  +DAG Y+C A
Sbjct: 3686 VNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLA 3745

Query: 102  TNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIA 161
            +N  GS      L VL+                            P    PS     + A
Sbjct: 3746 SNSAGSDRQGRDLRVLE----------------------------PPAIAPSPSNLTLTA 3777

Query: 162  RPVGSSVRLKCVASGHPRPDITWMKDDQAL--TRPEAAEPRKKKWTLSLKNLRPEDSGKY 219
                +   L C ASG P+P + W KD Q L     + A        L L    P+DS ++
Sbjct: 3778 H---TPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQF 3834

Query: 220  TCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQ 279
             C VSN  G  +  Y+V V       P        + TV         C       P + 
Sbjct: 3835 ECVVSNEVGEAHRLYQVTV-----HVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVS 3889

Query: 280  WLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICL 339
            W K    GA+      +   G  + V P+G             L I +A    AG Y C 
Sbjct: 3890 WSKA---GAQ------LGARGSGYRVSPSG------------ALEIGQALPIHAGRYTCS 3928

Query: 340  GANTMGYSFRSAFLTVLPDP 359
              N+ G + +  FLTV   P
Sbjct: 3929 ARNSAGVAHKHVFLTVQASP 3948



 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 92/378 (24%), Positives = 147/378 (38%), Gaps = 69/378 (18%)

Query: 28   PPKMADKVVPRQVARL-GRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGLKV 86
            PP + D   P +++   G  + L C  +G P P   W KDG+ +    +R     +  +V
Sbjct: 3493 PPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL----TRLENNSRATRV 3548

Query: 87   KQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWAR 146
             +V   DAG+Y C A +  G++  ++ + V                   Q  P       
Sbjct: 3549 LRVR--DAGLYTCLAESPAGAIEKSFRVRV-------------------QAPPNIVGPRG 3587

Query: 147  PRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTL 206
            PRF         V+    G  V L+C     P P ITW +D   L      +  ++   L
Sbjct: 3588 PRF---------VVGLAPGQLV-LECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFL 3637

Query: 207  SLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVL-TGTHPVNTTVDFGGTTS 265
             L+ L   DSG Y+C   N AG+ +  ++V++     + P + +G   VN +V+   T  
Sbjct: 3638 QLQALSTADSGDYSCTARNAAGSTSVAFRVEI----HTVPTIRSGPPAVNVSVN--QTAL 3691

Query: 266  FQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLI 325
              C+      P++ W K             +D    +F +LP G +  +P          
Sbjct: 3692 LPCQADGVPAPLVSWRK---------DRVPLDPRSPRFEILPEGSLRIQP---------- 3732

Query: 326  TRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIPA 385
                  DAG Y+CL +N+ G   +   L VL       P +A S S  +L       +P 
Sbjct: 3733 --VLAQDAGHYLCLASNSAGSDRQGRDLRVLEP-----PAIAPSPSNLTLTAHTPALLPC 3785

Query: 386  GAVFILGTLLLWLCQAQK 403
             A      L++W    QK
Sbjct: 3786 EASGSPKPLVVWWKDGQK 3803



 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 95/370 (25%), Positives = 144/370 (38%), Gaps = 77/370 (20%)

Query: 28   PPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--LK 85
            PP +    V + V     +V L+C   G PPP   W K  + + S W    V   G  L+
Sbjct: 1885 PPNIEPGPVNKAVLE-NASVTLECLASGVPPPDVSWFKGHQPV-SSWMGVTVSVDGRVLR 1942

Query: 86   VKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWA 145
            ++Q +  DAG Y C A+N  GS  + Y L V                             
Sbjct: 1943 IEQAQLSDAGSYRCVASNVAGSTELRYGLRVN---------------------------V 1975

Query: 146  RPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKW- 204
             PR T P  +   V+   V + VRL C A+G P P + W+KD   ++   A  P  + + 
Sbjct: 1976 PPRITLPPSLPGPVL---VNTPVRLTCNATGAPSPTLMWLKDGNPVS--PAGTPGLQVFP 2030

Query: 205  ---TLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFG 261
                L+L + R  DSG+Y+C   +  G      + DV+ +    P + G   +N +V   
Sbjct: 2031 GGRVLTLASARASDSGRYSCVAVSAVG----EDRQDVVLQVHMPPSILG-EELNVSVVAN 2085

Query: 262  GTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLN 321
             + + +C+  +   PV+ W K      +GR             + P   V    D + L 
Sbjct: 2086 ESVALECQSHAMPPPVLSWWK------DGR------------PLEPRPGVHLSADKALLQ 2127

Query: 322  KLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPP-----------GPPVASSS 370
               + RA   DAG Y C   N  G+S +   L V   P  P           G P + S 
Sbjct: 2128 ---VDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSC 2184

Query: 371  SATSLPWPVV 380
                +P+P +
Sbjct: 2185 ECRGVPFPKI 2194



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 84/355 (23%), Positives = 132/355 (37%), Gaps = 67/355 (18%)

Query: 7    LLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKD 66
            L +L+PP L+G   P              +    A L   + L C   G PPP   W + 
Sbjct: 2344 LSVLVPPELIGDLDP--------------LTNITAALHSPLTLLCEAMGIPPPAIRWFRG 2389

Query: 67   GRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGK 124
               +  G   + +L  G  LK+ Q + +D+G+Y C A+N  G    N+++ VL   S   
Sbjct: 2390 EEPVSPGEDTY-LLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIEN 2448

Query: 125  ESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITW 184
            E L                               VI    G +  L C  +GHP+P +TW
Sbjct: 2449 EDL-----------------------------EEVIKVLDGQTAHLMCNVTGHPQPKLTW 2479

Query: 185  MKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRS 244
             KD + L R +A         L +       +G Y+C  +N  G     +++ V+     
Sbjct: 2480 FKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTI 2539

Query: 245  KPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFV 304
                  +     TV      S  C+  +   P I W+K    GA    +  I        
Sbjct: 2540 LGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKD---GAPFEASRNIQ------- 2589

Query: 305  VLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP 359
            +LP             + L I  A+++DAG Y C+  N +G + ++  + VL  P
Sbjct: 2590 LLPG-----------THGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPP 2633



 Score = 83.6 bits (205), Expect = 4e-16
 Identities = 89/330 (26%), Positives = 123/330 (37%), Gaps = 67/330 (20%)

Query: 36   VPRQVA-RLGRTVRLQCPVEGDPPPLTMWTK-DGRTIH-----SGWSRFRVLPQG-LKVK 87
            +PR V   LGR+  L C   G PPP   W + DG+ +         SR R    G L  +
Sbjct: 791  LPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFE 850

Query: 88   QVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARP 147
             V  ED   YVC+A N FG +     L+V     P   S  P                  
Sbjct: 851  SVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTV---------------- 894

Query: 148  RFTQPSKMRRRVIARPVGSSVRLKC-VASGHPRPDITWMKDDQALTRPEAAEPRKKKWTL 206
                      RV+    G  V L C V +G P P+  W+KD + L  P +    +   +L
Sbjct: 895  ----------RVLE---GQPVSLPCIVLAGRPLPERHWLKDGRPLP-PGSRHSIRADGSL 940

Query: 207  SLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSF 266
             L     E +G+Y+C  +N AG+ +   ++ V    R  P  T TH +      G   S 
Sbjct: 941  HLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHP--TATHHITNE---GVPASL 995

Query: 267  QCKVRSDVKPVIQWLKRVE-YGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLI 325
             C       P I W K      + G H +    G                       LLI
Sbjct: 996  PCVASGVPAPTITWTKETNALTSRGPHYNVSKEG----------------------TLLI 1033

Query: 326  TRARQDDAGMYICLGANTMGYSFRSAFLTV 355
             +    DAG Y+C   NT+G+S +   L+V
Sbjct: 1034 AQPSAQDAGAYVCTATNTVGFSSQEMRLSV 1063



 Score = 83.6 bits (205), Expect = 4e-16
 Identities = 84/359 (23%), Positives = 133/359 (37%), Gaps = 69/359 (19%)

Query: 49   LQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCKATNGFG 106
            L C     PPP   W ++ + + +G     VL  G  L++  V  E+AG Y CKA+N  G
Sbjct: 2770 LYCDTNAIPPPDLTWYREDQPLSAG-DEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVG 2828

Query: 107  SLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGS 166
               ++Y L+VL           P    G  E+   +                 +     S
Sbjct: 2829 EDWLHYELLVLT----------PPVILGDTEELVEE-----------------VTVNASS 2861

Query: 167  SVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNR 226
            +V L+C A G+P P I+W+++    +     +  +    L +      D+  Y C   N+
Sbjct: 2862 TVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQ 2921

Query: 227  AGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEY 286
            AG+    + +    R +  P + G      T     + S  C V +   P + W K    
Sbjct: 2922 AGSAEKLFTL----RVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYK---- 2973

Query: 287  GAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGY 346
                  +  + +G + F++  T            + L + RAR  D+GMY C   N  G 
Sbjct: 2974 -----DSQALSLGEEVFLLPGT------------HTLQLGRARLSDSGMYTCEALNAAGR 3016

Query: 347  SFRSAFLTVLPDP----KPPGPPVA----------SSSSATSLPWPVVIGIPAGAVFIL 391
              +   L+VL  P     P GP  A           S    +LP P V     G   +L
Sbjct: 3017 DQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVL 3075



 Score = 82.4 bits (202), Expect = 9e-16
 Identities = 82/336 (24%), Positives = 127/336 (37%), Gaps = 64/336 (19%)

Query: 43   LGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKVKQVEREDAGVYVCKA 101
            +G  + L C  EG+P P   W+KDG  +          PQG +    +   DAG Y C+A
Sbjct: 1133 VGEALDLNCVAEGNPEPQLSWSKDGVVLQGRG------PQGSVHFAAIRTSDAGRYRCEA 1186

Query: 102  TNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIA 161
            +N  G  +    L VL+         G D +SG                        ++ 
Sbjct: 1187 SNSAGVDAWEVELRVLEP-----PHWGADETSG------------------------LLE 1217

Query: 162  RPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRK---KKWTLSLKNLRPEDSGK 218
            R  G +  L C A G P+P +TW K   +   P   +P     ++ +L L ++ P DSG 
Sbjct: 1218 RVAGENASLPCPARGTPKPQVTWRKGPSS--EPLHGQPGVAVLEEGSLFLASVSPADSGD 1275

Query: 219  YTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVI 278
            Y C+ +N  G+ +   K+ V        +       N +   G + + +C       P I
Sbjct: 1276 YECQATNEVGSTSRRAKLVVYV---PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEI 1332

Query: 279  QWLKRVE-------YGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQD 331
             WLK  +       +   G       VGG + +           +G  L+     R ++ 
Sbjct: 1333 VWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLL----------DEGQSLH---FPRIQEG 1379

Query: 332  DAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPVA 367
            D+G+Y C   N  G + R   L VL  P   G   A
Sbjct: 1380 DSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAA 1415



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 101/417 (24%), Positives = 145/417 (34%), Gaps = 98/417 (23%)

Query: 28  PPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQ-GLKV 86
           PP++     P      G T  L C V G+ P    W +D R + +   R   L    L++
Sbjct: 517 PPQLVP--APNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEI 574

Query: 87  KQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWAR 146
             +   D G Y C A+N  G    +  L+V +          P  S        SQ    
Sbjct: 575 SGIIPTDGGRYQCVASNANGVTRASVWLLVRE---------APQVSIHTSSQHFSQ---- 621

Query: 147 PRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTL 206
                             G  V++ C ASG+P P I+W ++ QAL           + TL
Sbjct: 622 ------------------GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV-DAQGTL 662

Query: 207 SLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSF 266
            ++ + PED+G Y+C+ +N  G    T    V       P ++  + V   V  G     
Sbjct: 663 IIQGVAPEDAGNYSCQATNEVGTDQET----VTLYYTDPPSVSAVNAV-VLVAVGEEAVL 717

Query: 267 QCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLIT 326
            C+      P + W +                GG + ++ P        +GS   KL I 
Sbjct: 718 VCEASGVPPPRVIWYR----------------GGLEMILAP--------EGSSSGKLRIP 753

Query: 327 RARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIPAG 386
            A++ DAG Y C   N +G +     L V   P+            T LP  V +     
Sbjct: 754 AAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQ-----------LTELPRDVTVE---- 798

Query: 387 AVFILGTLLLWLCQAQKKPCTPAPAPPLPGHRPPGTARDRSGDKDLPSLAALSAGPG 443
               LG   L  C+A                RPP T   R GD   P    L AG G
Sbjct: 799 ----LGRSALLACRAT--------------GRPPPTVTWRRGDGQ-PLGLRLGAGRG 836



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 102/410 (24%), Positives = 149/410 (36%), Gaps = 85/410 (20%)

Query: 20   PPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWS-RFR 78
            P  A  R PP     VV   VA L      +C   G PPP   W +DG+ + +    + +
Sbjct: 2256 PQIAGPREPPTQVS-VVQDGVATL------ECNATGKPPPTVTWERDGQPVGAELGLQLQ 2308

Query: 79   VLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQED 138
               Q L V++ +    G Y C A N  G     + L VL         + P+    G  D
Sbjct: 2309 NQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVL---------VPPELI--GDLD 2357

Query: 139  PASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAE 198
            P +                  I   + S + L C A G P P I W + ++ ++  E   
Sbjct: 2358 PLTN-----------------ITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTY 2400

Query: 199  PRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTV 258
                 W L +   + +DSG Y+C  SN AG     + V+V+     +        V   +
Sbjct: 2401 LLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIEN--EDLEEVIKVL 2458

Query: 259  DFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWS-RPDG 317
            D G T    C V    +P + W K      +GR              L  GD     PDG
Sbjct: 2459 D-GQTAHLMCNVTGHPQPKLTWFK------DGR-------------PLARGDAHHISPDG 2498

Query: 318  SYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPG-------------- 363
              L    + +A    AG Y C+ AN +G   +   L+VL  P   G              
Sbjct: 2499 VLLQ---VLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTV 2555

Query: 364  -PPVASSSSATSLPWPVVIGIPAGAVF--------ILGTLLLWLCQAQKK 404
              P++    A + P P +  +  GA F        + GT  L +  AQK+
Sbjct: 2556 NNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKE 2605



 Score = 79.3 bits (194), Expect = 7e-15
 Identities = 74/282 (26%), Positives = 106/282 (37%), Gaps = 58/282 (20%)

Query: 80   LPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDP 139
            LP  L++++V+  D G+Y C ATN  G       L VL                      
Sbjct: 1846 LPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLV--------------------- 1884

Query: 140  ASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEP 199
                   P   +P  + + V+     +SV L+C+ASG P PD++W K  Q ++       
Sbjct: 1885 -------PPNIEPGPVNKAVLEN---ASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTV 1934

Query: 200  RKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATY--KVDVIQRTRSKPVLTGTHPVNTT 257
                  L ++  +  D+G Y C  SN AG+    Y  +V+V  R    P L G   VNT 
Sbjct: 1935 SVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTP 1994

Query: 258  VDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDG 317
            V         C       P + WLK      +G  N     G     V P G V      
Sbjct: 1995 V------RLTCNATGAPSPTLMWLK------DG--NPVSPAGTPGLQVFPGGRV------ 2034

Query: 318  SYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP 359
                 L +  AR  D+G Y C+  + +G   +   L V   P
Sbjct: 2035 -----LTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPP 2071



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 81/329 (24%), Positives = 124/329 (37%), Gaps = 71/329 (21%)

Query: 40   VARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG----LKVKQVEREDAG 95
            V+R G  V + CPV G PP    W KDG  +       R L  G    L++ +V+  DAG
Sbjct: 3324 VSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQ---RTLLHGSGHTLRISKVQLADAG 3380

Query: 96   VYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKM 155
            ++ C A +  G    N+TL V                              P   +P + 
Sbjct: 3381 IFTCVAASPAGVADRNFTLQV----------------------------QVPPVLEPVEF 3412

Query: 156  RRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPED 215
            +  V+    GS V L C A G P P ++WMKD +    P  ++  ++  +L L+ +   D
Sbjct: 3413 QNDVVVVR-GSLVELPCEARGVPLPLVSWMKDGE----PLLSQSLEQGPSLQLEAVGAGD 3467

Query: 216  SGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVK 275
            SG Y+C   + AG     +++ V++      +     P   ++  G      C  +   +
Sbjct: 3468 SGTYSCVAVSEAGEARRHFQLTVMEPPH---IEDSGQPTELSLTPGAPMELLCDAQGTPQ 3524

Query: 276  PVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGM 335
            P I W K                 GQ    L      +R          + R R  DAG+
Sbjct: 3525 PNITWHK----------------DGQALTRLENNSRATR----------VLRVR--DAGL 3556

Query: 336  YICLGANTMGYSFRSAFLTVLPDPKPPGP 364
            Y CL  +  G   +S  + V   P   GP
Sbjct: 3557 YTCLAESPAGAIEKSFRVRVQAPPNIVGP 3585



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 106/415 (25%), Positives = 156/415 (37%), Gaps = 99/415 (23%)

Query: 44   GRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKVKQVEREDAGVYVCKAT 102
            G  V++ C   G P P   W+++ + +    SR  V  QG L ++ V  EDAG Y C+AT
Sbjct: 622  GVEVKVSCSASGYPTPHISWSRESQALQED-SRIHVDAQGTLIIQGVAPEDAGNYSCQAT 680

Query: 103  NGFGSLSVNYTLVVLDD-----------ISPGKES------------------------L 127
            N  G+     TL   D            ++ G+E+                        L
Sbjct: 681  NEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMIL 740

Query: 128  GPDSSSGGQ-EDPASQQWARPRFT----------------------QPSKMRRRVIARPV 164
             P+ SS G+   PA+Q+     +T                      Q +++ R V    +
Sbjct: 741  APEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVE-L 799

Query: 165  GSSVRLKCVASGHPRPDITWMKDDQA-----LTRPEAAEPRKK-KWTLSLKNLRPEDSGK 218
            G S  L C A+G P P +TW + D       L     +  R+     L  +++ PED   
Sbjct: 800  GRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAP 859

Query: 219  YTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVK-PV 277
            Y C   N  G + A  ++  I    + P +  + P    ++ G   S  C V +    P 
Sbjct: 860  YVCEARNVFGKVQAEARL--IVTGHAPPQIASSAPTVRVLE-GQPVSLPCIVLAGRPLPE 916

Query: 278  IQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWS-RPDGSYLNKLLITRARQDDAGMY 336
              WLK      +GR              LP G   S R DGS    L + RA Q+ AG Y
Sbjct: 917  RHWLK------DGRP-------------LPPGSRHSIRADGS----LHLDRALQEHAGRY 953

Query: 337  ICLGANTMGYSFRSAFLTVLPDPK---PPGPPVASSSSATSLPWPVVIGIPAGAV 388
             C+  NT G   R   L V   P+        + +     SLP  V  G+PA  +
Sbjct: 954  SCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPC-VASGVPAPTI 1007



 Score = 77.0 bits (188), Expect = 4e-14
 Identities = 82/351 (23%), Positives = 125/351 (35%), Gaps = 73/351 (20%)

Query: 44   GRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWS---RFRVLPQGLKVKQVEREDAGVYVCK 100
            G+ VRL C  +G PPP   W KDG  +        RF +    L +K +   DAG Y C 
Sbjct: 3232 GQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCV 3291

Query: 101  ATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVI 160
            A N  G  +  +T+ VL    P     G D S                          ++
Sbjct: 3292 AHNPAGEDARLHTVNVL---VPPTIKQGADGSG------------------------TLV 3324

Query: 161  ARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYT 220
            +RP G  V + C   G P   ++W+KD   L   +         TL +  ++  D+G +T
Sbjct: 3325 SRP-GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFT 3383

Query: 221  CRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDF-GGTTSFQCKVRSDVKPVIQ 279
            C  ++ AG  +  + + V    +  PVL      N  V   G      C+ R    P++ 
Sbjct: 3384 CVAASPAGVADRNFTLQV----QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVS 3439

Query: 280  WLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICL 339
            W+K      E   + +++ G                       L +      D+G Y C+
Sbjct: 3440 WMK----DGEPLLSQSLEQG---------------------PSLQLEAVGAGDSGTYSCV 3474

Query: 340  GANTMGYSFRSAFLTVLPDPK------------PPGPPVASSSSATSLPWP 378
              +  G + R   LTV+  P              PG P+     A   P P
Sbjct: 3475 AVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQP 3525



 Score = 75.9 bits (185), Expect = 8e-14
 Identities = 74/323 (22%), Positives = 124/323 (38%), Gaps = 58/323 (17%)

Query: 42   RLGRTVRLQCPVEGDPPPLTMWTKDGRTIH---SGWSRFRVLPQGLKVKQVEREDAGVYV 98
            R G    L C   G P P   W KDG+ +    +G      + + L + Q +    G Y 
Sbjct: 2175 REGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYT 2234

Query: 99   CKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRR 158
            C+ +N  G+ S +  L          E   P   +G +E P          TQ S ++  
Sbjct: 2235 CECSNVVGNSSQDLQL----------EVHVPPQIAGPREPP----------TQVSVVQDG 2274

Query: 159  VIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGK 218
            V          L+C A+G P P +TW +D Q +      + + +  +L ++  +   +G+
Sbjct: 2275 VAT--------LECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGR 2326

Query: 219  YTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHP--VNTTVDFGGTTSFQCKVRSDVKP 276
            Y+C   N AG     +++ V+      P L G      N T       +  C+      P
Sbjct: 2327 YSCVAENLAGRAERKFELSVL----VPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPP 2382

Query: 277  VIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMY 336
             I+W +  E  + G     +  G            W          L +T+ ++ D+G+Y
Sbjct: 2383 AIRWFRGEEPVSPGEDTYLLAGG------------W---------MLKMTQTQEQDSGLY 2421

Query: 337  ICLGANTMGYSFRSAFLTVLPDP 359
             CL +N  G + R+  + VL  P
Sbjct: 2422 SCLASNEAGEARRNFSVEVLVPP 2444



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 98/410 (23%), Positives = 147/410 (35%), Gaps = 69/410 (16%)

Query: 43   LGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCK 100
            +G+ + L C   G P P   W ++GR      +  +V  QG  L +  VE + +G++ C+
Sbjct: 1703 VGQPLELPCQASGSPVPTIQWLQNGRPAEE-LAGVQVASQGTTLHIDHVELDHSGLFACQ 1761

Query: 101  ATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVI 160
            ATN  G+      + V  + +PG   +       G E  +S     P    P       +
Sbjct: 1762 ATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSF----PAACDPP------V 1811

Query: 161  ARPVGSSVRLKCVASGHPRPDIT--WMKDDQALTRPEAAEPRKK-KWTLSLKNLRPEDSG 217
             R  G+          HP+P +   W         P            L ++ +   D G
Sbjct: 1812 HRGWGA----------HPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEG 1861

Query: 218  KYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPV 277
             YTC  +N AG       + V+     +P      PVN  V    + + +C       P 
Sbjct: 1862 IYTCAATNLAGESKREVALKVLVPPNIEP-----GPVNKAVLENASVTLECLASGVPPPD 1916

Query: 278  IQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYI 337
            + W K  +         T+ V G+                     L I +A+  DAG Y 
Sbjct: 1917 VSWFKGHQ-PVSSWMGVTVSVDGRV--------------------LRIEQAQLSDAGSYR 1955

Query: 338  CLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIP----AGAVFILGT 393
            C+ +N  G +     L V   P+   PP        SLP PV++  P      A      
Sbjct: 1956 CVASNVAGSTELRYGLRVNVPPRITLPP--------SLPGPVLVNTPVRLTCNATGAPSP 2007

Query: 394  LLLWLCQAQKKPCTPAPAPPL---PGHRPPGTARDRSGDKDLPSLAALSA 440
             L+WL      P +PA  P L   PG R    A  R+ D    S  A+SA
Sbjct: 2008 TLMWL--KDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSA 2055



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 84/335 (25%), Positives = 116/335 (34%), Gaps = 73/335 (21%)

Query: 44   GRTVRLQCPVEGDPPPLTMWTK--DGRTIHSGWSRFRVLPQG-LKVKQVEREDAGVYVCK 100
            G    L CP  G P P   W K      +H G     VL +G L +  V   D+G Y C+
Sbjct: 1221 GENASLPCPARGTPKPQVTWRKGPSSEPLH-GQPGVAVLEEGSLFLASVSPADSGDYECQ 1279

Query: 101  ATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVI 160
            ATN  GS S    LVV          + P     G                    R+  +
Sbjct: 1280 ATNEVGSTSRRAKLVVY---------VPPSIREDG--------------------RKANV 1310

Query: 161  ARPVGSSVRLKCVASGHPRPDITWMKDDQALTRP--EAAEPRKKKW-------------T 205
            +   G S+ L+C A+G P P+I W+KD Q +  P   A       W             +
Sbjct: 1311 SGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQS 1370

Query: 206  LSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGT-T 264
            L    ++  DSG Y+CR  N+AG     + + V+    + P + G       +   G   
Sbjct: 1371 LHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVL----TPPSVLGAGAAQEVLGLAGADV 1426

Query: 265  SFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLL 324
              QC       P ++W K             +  GG    V   G V           L 
Sbjct: 1427 ELQCWTSGVPTPQVEWTK---------DRQPVLPGGPHLQVQEDGQV-----------LR 1466

Query: 325  ITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP 359
            IT +   D G Y C+  +  G   R   L V   P
Sbjct: 1467 ITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPP 1501



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 78/302 (25%), Positives = 110/302 (36%), Gaps = 57/302 (18%)

Query: 47   VRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG---LKVKQVEREDAGVYVCKATN 103
            V+L C   G P P   W KDG  + +  S   V  +G   L++ + +  DAGVY CKA+N
Sbjct: 1520 VQLLCEARGVPTPNITWFKDGALLPT--STKVVYTRGGRQLQLGRAQSSDAGVYTCKASN 1577

Query: 104  GFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARP 163
              G+      L V   + P  E  G                           R  V+   
Sbjct: 1578 AVGAAEKATRLDVY--VPPTIEGAGG--------------------------RPYVVKAV 1609

Query: 164  VGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRV 223
             G  V L+CVA GHP P ++W  +   +     +        L L++     SG Y+C  
Sbjct: 1610 AGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVA 1669

Query: 224  SNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKR 283
            S+ AG     Y V+V Q      V  G   V T V  G      C+      P IQWL+ 
Sbjct: 1670 SSPAGEAVLQYSVEV-QVPPQLLVAEGLGQVTTIV--GQPLELPCQASGSPVPTIQWLQN 1726

Query: 284  VEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANT 343
               G      + + V  Q               G+ L+   I     D +G++ C   N 
Sbjct: 1727 ---GRPAEELAGVQVASQ---------------GTTLH---IDHVELDHSGLFACQATNE 1765

Query: 344  MG 345
             G
Sbjct: 1766 AG 1767



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 91/402 (22%), Positives = 144/402 (35%), Gaps = 90/402 (22%)

Query: 7    LLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKD 66
            L +LL P +LG         G    AD+ V      +   + L C     P P   W KD
Sbjct: 2531 LSVLLAPTILG---------GAEDSADEEV---TVTVNNPISLICEALAFPSPNITWMKD 2578

Query: 67   GRTIHSGWSRFRVLP--QGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGK 124
            G    +     ++LP   GL++   ++EDAG Y C  TN  G    NY + VL  I P  
Sbjct: 2579 GAPFEAS-RNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVL--IPP-- 2633

Query: 125  ESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITW 184
                    S  ++DP  +   +             +   V S++ L+C +   P P I W
Sbjct: 2634 --------SISKDDPLGEVGVKE------------VKTKVNSTLTLECESWAVPPPTIRW 2673

Query: 185  MKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRS 244
             KD Q +T     +   +   L ++  +  DSG+Y C  +N AG  +  + V +    + 
Sbjct: 2674 YKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI----QV 2729

Query: 245  KPVLTGTHPVNTTVDF--------GGTTSFQ-----------CKVRSDVKPVIQWLKRVE 285
             P+       +   +         GG T ++           C   +   P + W +  +
Sbjct: 2730 PPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQ 2789

Query: 286  YGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMG 345
              + G   S +  G                       L I   R ++AG Y C  +N +G
Sbjct: 2790 PLSAGDEVSVLQGG---------------------RVLQIPLVRAENAGRYSCKASNEVG 2828

Query: 346  YSFRSAFLTVLPDPKPPGPP-------VASSSSATSLPWPVV 380
              +    L VL  P   G           ++SS  SL  P +
Sbjct: 2829 EDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPAL 2870



 Score = 72.8 bits (177), Expect = 7e-13
 Identities = 98/404 (24%), Positives = 139/404 (34%), Gaps = 92/404 (22%)

Query: 7    LLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKD 66
            LL+L PP +LGA     AA+    +A           G  V LQC   G P P   WTKD
Sbjct: 1401 LLVLTPPSVLGA----GAAQEVLGLA-----------GADVELQCWTSGVPTPQVEWTKD 1445

Query: 67   GRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGK 124
             + +  G    +V   G  L++      D G Y C A +  G  + ++ L V        
Sbjct: 1446 RQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVH------- 1498

Query: 125  ESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITW 184
                P +  G  E                      +A      V+L C A G P P+ITW
Sbjct: 1499 ---APPTIWGSNETGE-------------------VAVMEDHLVQLLCEARGVPTPNITW 1536

Query: 185  MKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRS 244
             KD   L         +    L L   +  D+G YTC+ SN  GA     ++DV      
Sbjct: 1537 FKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY----V 1592

Query: 245  KPVLTGT--HPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQK 302
             P + G    P       G   + +C  R    P + W           H+  + V    
Sbjct: 1593 PPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSW-----------HHEGLPVAESN 1641

Query: 303  FVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPP 362
               L T       DGS L    +    +  +G+Y C+ ++                  P 
Sbjct: 1642 ESRLET-------DGSVLR---LESPGEASSGLYSCVASS------------------PA 1673

Query: 363  GPPVASSSSATSLPWPVVIGIPAGAV-FILGTLLLWLCQAQKKP 405
            G  V   S    +P  +++    G V  I+G  L   CQA   P
Sbjct: 1674 GEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSP 1717



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 82/321 (25%), Positives = 112/321 (34%), Gaps = 57/321 (17%)

Query: 47   VRLQCPVEGDPPPLTMWTKDGRTIH-SGWSRFRVLPQG--LKVKQVEREDAGVYVCKATN 103
            VRL C   G P P  MW KDG  +  +G    +V P G  L +      D+G Y C A +
Sbjct: 1995 VRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVS 2054

Query: 104  GFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARP 163
              G    +  L V            P S  G                   ++   V+A  
Sbjct: 2055 AVGEDRQDVVLQVHM----------PPSILG------------------EELNVSVVAN- 2085

Query: 164  VGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRV 223
               SV L+C +   P P ++W KD + L           K  L +      D+G YTC  
Sbjct: 2086 --ESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEA 2143

Query: 224  SNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKR 283
             N+AG     Y ++V       PV         TV  G  TS  C+ R    P I W K 
Sbjct: 2144 LNQAGHSEKHYNLNV----WVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRK- 2198

Query: 284  VEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANT 343
                            GQ    LP      +   +    L + +A+    G Y C  +N 
Sbjct: 2199 ---------------DGQP---LPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNV 2240

Query: 344  MGYSFRSAFLTVLPDPKPPGP 364
            +G S +   L V   P+  GP
Sbjct: 2241 VGNSSQDLQLEVHVPPQIAGP 2261



 Score = 36.2 bits (82), Expect = 0.072
 Identities = 43/176 (24%), Positives = 63/176 (35%), Gaps = 40/176 (22%)

Query: 215 DSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDV 274
           + G Y C   +RAG   A  ++ V   T   P L      N TV  G T    C+V  + 
Sbjct: 490 EEGTYECTAVSRAGTGRAKAQIVV---TDPPPQLVPAP--NVTVSPGETAVLSCRVLGEA 544

Query: 275 KPVIQWLK--RVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDD 332
              + W++  RV   + GR     D+  +   ++PT                       D
Sbjct: 545 PYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPT-----------------------D 581

Query: 333 AGMYICLGANTMGYSFRSAFLTVLPDPK----------PPGPPVASSSSATSLPWP 378
            G Y C+ +N  G +  S +L V   P+            G  V  S SA+  P P
Sbjct: 582 GGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTP 637


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score =  105 bits (262), Expect = 1e-22
 Identities = 92/342 (26%), Positives = 141/342 (41%), Gaps = 59/342 (17%)

Query: 28   PPKMADKVVPRQVARL-GRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--L 84
            PP M + +   ++  L G +  + C  +G P P   W +DG+ +    +   V   G  L
Sbjct: 3433 PPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLD-AHLTVSTHGMVL 3491

Query: 85   KVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQW 144
            ++ + E ED+G Y C A+N  G +S ++ L VL+          P   +G +E       
Sbjct: 3492 QLLKAETEDSGKYTCIASNEAGEVSKHFILKVLE----------PPHINGSEE------- 3534

Query: 145  ARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKW 204
                           I+  V + + L C+ASG P P +TWMKD + L + +  +      
Sbjct: 3535 ------------HEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGE 3582

Query: 205  TLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGT-HPVNTTVDFGGT 263
             L +   + ED+G+YTC  S+ AG  +  Y V    R    P + GT  P + TV     
Sbjct: 3583 VLRISTAQVEDTGRYTCLASSPAGDDDKEYLV----RVHVPPNIAGTDEPRDITVLRNRQ 3638

Query: 264  TSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKL 323
             + +CK  +   PVI WL+                 G++    P   + S   G YL   
Sbjct: 3639 VTLECKSDAVPPPVITWLR----------------NGERLQATPRVRILS--GGRYLQ-- 3678

Query: 324  LITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPP 365
             I  A   D   Y C+ +N  G + R   LTV   P   G P
Sbjct: 3679 -INNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGP 3719



 Score =  100 bits (248), Expect = 4e-21
 Identities = 84/321 (26%), Positives = 122/321 (38%), Gaps = 58/321 (18%)

Query: 44   GRTVRLQCPVEGDPPPLTMWTKDGRTIHS-GWSRFRVLPQG--LKVKQVEREDAGVYVCK 100
            G  + L C   G PPP  +W K G  + +    R R+L  G  L++   E+ DA +Y C 
Sbjct: 2211 GNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCV 2270

Query: 101  ATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVI 160
            A+N  G+    Y L                           Q + RP  T        +I
Sbjct: 2271 ASNVAGTAKKEYNL---------------------------QVYIRPTITNSGSHPTEII 2303

Query: 161  ARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYT 220
                G S+ L+C   G P P +TWMKD   L + +  E   +   L LKN+   D+G+Y 
Sbjct: 2304 VTR-GKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYV 2362

Query: 221  CRVSNRAGAINATYKVDVIQRTRSKPVLTGTH--PVNTTVDFGGTTSFQCKVRSDVKPVI 278
            C   N AG  +  Y + V     + P + G H  P N +V    + S  C+      P I
Sbjct: 2363 CVAVNVAGMTDKKYDLSV----HAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSI 2418

Query: 279  QWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYIC 338
             W K  +       NS   + G +                    L + +   +DAG Y C
Sbjct: 2419 TWFK--DGWPVSLSNSVRILSGGRM-------------------LRLMQTTMEDAGQYTC 2457

Query: 339  LGANTMGYSFRSAFLTVLPDP 359
            +  N  G   +   L+VL  P
Sbjct: 2458 VVRNAAGEERKIFGLSVLVPP 2478



 Score = 96.7 bits (239), Expect = 4e-20
 Identities = 84/319 (26%), Positives = 120/319 (37%), Gaps = 55/319 (17%)

Query: 43   LGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCK 100
            +   + L C     PPP   W KDG  + S   +  +LP G  L++ + + EDAG Y C 
Sbjct: 2791 INNPISLYCETNAAPPPTLTWYKDGHPLTSS-DKVLILPGGRVLQIPRAKVEDAGRYTCV 2849

Query: 101  ATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVI 160
            A N  G  S+ Y + VL           P    G   D   +                 +
Sbjct: 2850 AVNEAGEDSLQYDVRVLV----------PPIIKGANSDLPEE-----------------V 2882

Query: 161  ARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYT 220
               V  S  ++C++SG P P  +W KD Q L   +  +       L + N +  D G+Y 
Sbjct: 2883 TVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYV 2942

Query: 221  CRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQW 280
            C   N AG+    + ++V       P + G    N TV      S  C+V     P + W
Sbjct: 2943 CVAENTAGSAKKYFNLNV----HVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSW 2998

Query: 281  LKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLG 340
            LK  E   +   N+ I  GG+                     L I RA+  D G Y C+ 
Sbjct: 2999 LKN-EQPIKLNTNTLIVPGGR--------------------TLQIIRAKVSDGGEYTCIA 3037

Query: 341  ANTMGYSFRSAFLTVLPDP 359
             N  G S +   LTV   P
Sbjct: 3038 INQAGESKKKFSLTVYVPP 3056



 Score = 95.9 bits (237), Expect = 8e-20
 Identities = 91/323 (28%), Positives = 125/323 (38%), Gaps = 59/323 (18%)

Query: 42   RLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVC 99
            R G +V L+C     PPP+  W K+GR I    +   +L  G  L +K+ E  D G YVC
Sbjct: 3072 REGTSVSLECESNAVPPPVITWYKNGRMITES-THVEILADGQMLHIKKAEVSDTGQYVC 3130

Query: 100  KATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRV 159
            +A N  G    N+ L V   + P  E  GP+                          R V
Sbjct: 3131 RAINVAGRDDKNFHLNVY--VPPSIE--GPE--------------------------REV 3160

Query: 160  IARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPE--DSG 217
            I   + + V L C A+G P P I W+K+ + +   ++ E R       L+  R +  DSG
Sbjct: 3161 IVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSG 3220

Query: 218  KYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTH-PVNTTVDFGGTTSFQCKVRSDVKP 276
             YTC  SN  G     Y + +    +  P + G   P + +V  G      C       P
Sbjct: 3221 NYTCIASNMEGKAQKYYFLSI----QVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTP 3276

Query: 277  VIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMY 336
            +IQWLK  +  A G                 T  +    +GS LN   I  A   D G Y
Sbjct: 3277 LIQWLKDGKPIASGE----------------TERIRVSANGSTLN---IYGALTSDTGKY 3317

Query: 337  ICLGANTMGYSFRSAFLTVLPDP 359
             C+  N  G   R   L V   P
Sbjct: 3318 TCVATNPAGEEDRIFNLNVYVTP 3340



 Score = 94.4 bits (233), Expect = 2e-19
 Identities = 91/347 (26%), Positives = 130/347 (37%), Gaps = 62/347 (17%)

Query: 16   LGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWS 75
            L    P    RGP  +  +V        G+ V + C  +G P P+  W+K G T+     
Sbjct: 1165 LNVHVPPKIQRGPKHLKVQV--------GQRVDIPCNAQGTPLPVITWSKGGSTMLVDGE 1216

Query: 76   RFRVLPQG-LKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSG 134
                 P G L + Q    DAG+Y C ATN  G+     TL V +   P  E L P  ++ 
Sbjct: 1217 HHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQE--PPTVEDLEPPYNTT 1274

Query: 135  GQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRP 194
             QE  A+Q+                        +   C A G P+P I W+ + + LT  
Sbjct: 1275 FQERVANQR------------------------IEFPCPAKGTPKPTIKWLHNGRELTGR 1310

Query: 195  EAAEPRKKKWT-LSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHP 253
            E      +  T L + ++ P D+G+Y C   N AG     Y + V       PV+     
Sbjct: 1311 EPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKV----HVPPVIKDKEQ 1366

Query: 254  V-NTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVW 312
            V N +V     T+  C+V     P+I W K      E     T++ G             
Sbjct: 1367 VTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNG------------- 1413

Query: 313  SRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP 359
                      L + RA  +DAG Y C   N  G S +   + VL  P
Sbjct: 1414 --------KILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPP 1452



 Score = 93.2 bits (230), Expect = 5e-19
 Identities = 84/338 (24%), Positives = 131/338 (38%), Gaps = 56/338 (16%)

Query: 28   PPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--LK 85
            PP +    +  +V    + V LQC   G P P   W KD + +++     ++   G  L+
Sbjct: 1825 PPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQ 1884

Query: 86   VKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWA 145
            + +   EDAG Y C ATN  G    +  L V +                           
Sbjct: 1885 IAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEP-------------------------- 1918

Query: 146  RPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWT 205
             P      KM    +   V + V+L+C A+G+P P ITW KD++ L+   +     +   
Sbjct: 1919 -PSLEDAGKMLNETVL--VSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQI 1975

Query: 206  LSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTS 265
            + +++ +  D+G Y C   N AGA    Y + V       P ++G++ +   V       
Sbjct: 1976 IDIESAQISDAGIYKCVAINSAGATELFYSLQV----HVAPSISGSNNM-VAVVVNNPVR 2030

Query: 266  FQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLI 325
             +C+ R    P + WLK      +G   S+   G Q   VL  G +           L +
Sbjct: 2031 LECEARGIPAPSLTWLK------DGSPVSSFSNGLQ---VLSGGRI-----------LAL 2070

Query: 326  TRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPG 363
            T A+  D G Y C+  N  G   R   L V   P   G
Sbjct: 2071 TSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMG 2108



 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 86/323 (26%), Positives = 123/323 (38%), Gaps = 57/323 (17%)

Query: 44   GRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCKA 101
            G+++ L+C V+G PPP   W KDG  +        +L +G  L++K +   D G YVC A
Sbjct: 2307 GKSISLECEVQGIPPPTVTWMKDGHPLIKA-KGVEILDEGHILQLKNIHVSDTGRYVCVA 2365

Query: 102  TNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIA 161
             N  G     Y L V            P S  G    P +                  I+
Sbjct: 2366 VNVAGMTDKKYDLSVH----------APPSIIGNHRSPEN------------------IS 2397

Query: 162  RPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTC 221
                +SV L C ASG P P ITW KD   ++   +         L L     ED+G+YTC
Sbjct: 2398 VVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTC 2457

Query: 222  RVSNRAGAINATYKVDVIQRTRSKPVLTGTHPV-NTTVDFGGTTSFQCKVRSDVKPVIQW 280
             V N AG     + + V+      P + G + + +  V    + +  C+V  +  P I W
Sbjct: 2458 VVRNAAGEERKIFGLSVL----VPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITW 2513

Query: 281  LKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLG 340
             K  +   E   +  I   G +F                   L IT  +    G Y CL 
Sbjct: 2514 HKDGQPLQEDEAHHII--SGGRF-------------------LQITNVQVPHTGRYTCLA 2552

Query: 341  ANTMGYSFRSAFLTVLPDPKPPG 363
            ++  G+  RS  L V   P   G
Sbjct: 2553 SSPAGHKSRSFSLNVFVSPTIAG 2575



 Score = 90.9 bits (224), Expect = 2e-18
 Identities = 89/336 (26%), Positives = 126/336 (37%), Gaps = 56/336 (16%)

Query: 28   PPKMADKVVPRQVA-RLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSG-WSRFRVLPQG-- 83
            PP +A   +P  V+  LG  V L C   G P PL  W KDG+ I SG   R RV   G  
Sbjct: 3244 PPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGST 3303

Query: 84   LKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQ 143
            L +      D G Y C ATN  G     + L V   ++P         +  G +D A + 
Sbjct: 3304 LNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVY--VTP---------TIRGNKDEAEK- 3351

Query: 144  WARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKK 203
                            +   V +S+ ++C A+G P P I W+K+   L            
Sbjct: 3352 ----------------LMTLVDTSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAG 3395

Query: 204  WTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGT 263
              + +   +  D   YTC  SNRAG  N  Y + V         + GT  +  TV  G +
Sbjct: 3396 QVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSM-GTEEI--TVLKGSS 3452

Query: 264  TSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKL 323
            TS  C       P + WL+  +      H  T+   G                      L
Sbjct: 3453 TSMACITDGTPAPSMAWLRDGQPLGLDAH-LTVSTHGM--------------------VL 3491

Query: 324  LITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP 359
             + +A  +D+G Y C+ +N  G   +   L VL  P
Sbjct: 3492 QLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPP 3527



 Score = 89.4 bits (220), Expect = 7e-18
 Identities = 87/366 (23%), Positives = 132/366 (36%), Gaps = 69/366 (18%)

Query: 28   PPKMADKVVPRQVARL-GRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--L 84
            PP +A    PR +  L  R V L+C  +  PPP+  W ++G  + +   R R+L  G  L
Sbjct: 3619 PPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQAT-PRVRILSGGRYL 3677

Query: 85   KVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQW 144
            ++   +  D   Y C A+N  G  +  + L V         ++ P+   G Q        
Sbjct: 3678 QINNADLGDTANYTCVASNIAGKTTREFILTV---------NVPPNIKGGPQS------- 3721

Query: 145  ARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKW 204
                           +   +  S  L+C+A G P P ITW KD   L    A     +  
Sbjct: 3722 ---------------LVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENG 3766

Query: 205  TLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTT 264
             L +++    D+G+Y C  +N AG       + V       P      P N TV     T
Sbjct: 3767 FLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQV-----HVPPSIAPGPTNMTVIVNVQT 3821

Query: 265  SFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLL 324
            +  C+     KP I W K         H   +D     + +L +G             L+
Sbjct: 3822 TLACEATGIPKPSINWRK-------NGHLLNVDQNQNSYRLLSSG------------SLV 3862

Query: 325  ITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPK----------PPGPPVASSSSATS 374
            I     DD   Y C   N  G   R+  LTV   P               P   + +A+ 
Sbjct: 3863 IISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASG 3922

Query: 375  LPWPVV 380
            +P+P +
Sbjct: 3923 VPFPSI 3928



 Score = 89.0 bits (219), Expect = 9e-18
 Identities = 95/362 (26%), Positives = 134/362 (37%), Gaps = 87/362 (24%)

Query: 49   LQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKVKQVEREDAGVYVCKATNGFG- 106
            L C  +G P P   W KD   + +   ++   P G L ++ V  ED+G Y C A N  G 
Sbjct: 4188 LPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGE 4247

Query: 107  -SLSVNYTLVVLDDIS--PGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARP 163
             + +V+ T+ VL   +  PG  SL                                    
Sbjct: 4248 DTHTVSLTVHVLPTFTELPGDVSLNK---------------------------------- 4273

Query: 164  VGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRV 223
             G  +RL C A+G P P +TW  ++  +  P   +       L ++ +  EDSG Y C  
Sbjct: 4274 -GEQLRLSCKATGIPLPKLTWTFNNNII--PAHFDSVNGHSELVIERVSKEDSGTYVCTA 4330

Query: 224  SNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKR 283
             N  G + A   V V    +  PV  G +P N     GG     C+V+ D  P IQW   
Sbjct: 4331 ENSVGFVKAIGFVYV----KEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQW--- 4383

Query: 284  VEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANT 343
                   R    I++  +         +    +GS    L I     +DAG Y C+  N 
Sbjct: 4384 ------NRKGVDIEISHR---------IRQLGNGS----LAIYGTVNEDAGDYTCVATNE 4424

Query: 344  MGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWLCQAQK 403
             G   RS  LT+        PP+ +         PV   I AG   IL       CQA  
Sbjct: 4425 AGVVERSMSLTL------QSPPIITLE-------PVETVINAGGKIILN------CQATG 4465

Query: 404  KP 405
            +P
Sbjct: 4466 EP 4467



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 84/352 (23%), Positives = 126/352 (35%), Gaps = 62/352 (17%)

Query: 28   PPKMADKVVPRQVARLGRT----VRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG 83
            PP + D   P       R     +   CP +G P P   W  +GR +        +L  G
Sbjct: 1261 PPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDG 1320

Query: 84   --LKVKQVEREDAGVYVCKATNGFGSLSVNYTLVV-LDDISPGKESLGPDSSSGGQEDPA 140
              L +  V   D G Y+C A N  G+    Y L V +  +   KE +             
Sbjct: 1321 TLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQV------------- 1367

Query: 141  SQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPR 200
                     T  S +  ++          L C   G P P I W KD+  +T     +  
Sbjct: 1368 ---------TNVSVLLNQL--------TNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTV 1410

Query: 201  KKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTH-PVNTTVD 259
                 L L    PED+G+Y+C+  N AG     + +DV+      P + GT+ P   +V 
Sbjct: 1411 NNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVL----VPPTIIGTNFPNEVSVV 1466

Query: 260  FGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSY 319
                 + +C+V+    P I W K             + +G     +L  G V        
Sbjct: 1467 LNRDVALECQVKGTPFPDIHWFK---------DGKPLFLGDPNVELLDRGQV-------- 1509

Query: 320  LNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSS 371
               L +  AR++D G Y C  +N  G   +   LT+   P   G  V +  S
Sbjct: 1510 ---LHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDIS 1558



 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 89/372 (23%), Positives = 137/372 (36%), Gaps = 75/372 (20%)

Query: 28   PP--KMADKVVPRQVARL-GRTVRLQCPVEGDPPPLTMWTKDGRTI-----HSGWSRFRV 79
            PP  K A+  +P +V  L  ++  ++C   G P P   W KDG+ +     H   S  R+
Sbjct: 2868 PPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRI 2927

Query: 80   LPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDP 139
                L++   +  D G YVC A N  GS    + L    ++      +GP S +      
Sbjct: 2928 ----LQILNTQITDIGRYVCVAENTAGSAKKYFNL----NVHVPPSVIGPKSEN------ 2973

Query: 140  ASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEP 199
                                +   V + + L C  SG P PD++W+K++Q +        
Sbjct: 2974 --------------------LTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLI 3013

Query: 200  RKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVD 259
                 TL +   +  D G+YTC   N+AG     + + V      K   + +  V   V 
Sbjct: 3014 VPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSV-VNVR 3072

Query: 260  FGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSY 319
             G + S +C+  +   PVI W K      E  H   +                   DG  
Sbjct: 3073 EGTSVSLECESNAVPPPVITWYKNGRMITESTHVEIL------------------ADGQM 3114

Query: 320  LNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGP-----------PVAS 368
            L+   I +A   D G Y+C   N  G   ++  L V   P   GP           PV  
Sbjct: 3115 LH---IKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTL 3171

Query: 369  SSSATSLPWPVV 380
            +  AT +P P +
Sbjct: 3172 TCDATGIPPPTI 3183



 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 89/350 (25%), Positives = 131/350 (37%), Gaps = 75/350 (21%)

Query: 43   LGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKVKQVEREDAGVYVCKA 101
            L   + L C   G P P   W K+G  +++      VLP G L++ +  REDAG Y+C A
Sbjct: 4001 LNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVA 4060

Query: 102  TNGFGSL--SVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRV 159
             N  G+    +   + V   ISP                                ++  V
Sbjct: 4061 QNPAGTALGKIKLNVQVPPVISP-------------------------------HLKEYV 4089

Query: 160  IARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPR-KKKWTLSLKNLRPEDSGK 218
            IA  V   + L C A G P PDITW KD +A+   E+   R     +L +  ++P D+G 
Sbjct: 4090 IA--VDKPITLSCEADGLPPPDITWHKDGRAIV--ESIRQRVLSSGSLQIAFVQPGDAGH 4145

Query: 219  YTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVI 278
            YTC  +N AG+ + + K+ V       P +  T   + TV+        C       P I
Sbjct: 4146 YTCMAANVAGSSSTSTKLTV----HVPPRIRSTEG-HYTVNENSQAILPCVADGIPTPAI 4200

Query: 279  QWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYIC 338
             W K          N  +     K+   P G+            L++     +D+G Y C
Sbjct: 4201 NWKK---------DNVLLANLLGKYTAEPYGE------------LILENVVLEDSGFYTC 4239

Query: 339  LGANTMGYSFRSAFLTVLPDPK----------PPGPPVASSSSATSLPWP 378
            +  N  G    +  LTV   P             G  +  S  AT +P P
Sbjct: 4240 VANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLP 4289



 Score = 86.3 bits (212), Expect = 6e-17
 Identities = 82/305 (26%), Positives = 120/305 (39%), Gaps = 59/305 (19%)

Query: 46   TVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCKATN 103
            +V L C   G P P   W KDG  +    S  R+L  G  L++ Q   EDAG Y C   N
Sbjct: 2403 SVSLTCEASGIPLPSITWFKDGWPVSLSNS-VRILSGGRMLRLMQTTMEDAGQYTCVVRN 2461

Query: 104  GFGSLSVNYTLVVLDDISP---GKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVI 160
              G     + L VL  + P   G+ +L                       +  K++ +  
Sbjct: 2462 AAGEERKIFGLSVL--VPPHIVGENTL-----------------------EDVKVKEK-- 2494

Query: 161  ARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYT 220
                  SV L C  +G+P P+ITW KD Q L   EA         L + N++   +G+YT
Sbjct: 2495 -----QSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYT 2549

Query: 221  CRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQW 280
            C  S+ AG  + ++ ++V        V +  +P + TV     TS  C+  S     I W
Sbjct: 2550 CLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITW 2609

Query: 281  LKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLG 340
             K          + T     +   +LP G             L I  A++D+AG Y C+ 
Sbjct: 2610 FK----------DGTPLESNRNIRILPGG-----------RTLQILNAQEDNAGRYSCVA 2648

Query: 341  ANTMG 345
             N  G
Sbjct: 2649 TNEAG 2653



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 97/358 (27%), Positives = 136/358 (37%), Gaps = 64/358 (17%)

Query: 28   PPKMADKVVPRQVA-RLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--L 84
            PP + DK     V+  L +   L C VEG P P+ MW KD   +    S  + +  G  L
Sbjct: 1358 PPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTES-STIQTVNNGKIL 1416

Query: 85   KVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQW 144
            K+ +   EDAG Y CKA N  G+    + + VL  + P         +  G   P     
Sbjct: 1417 KLFRATPEDAGRYSCKAINIAGTSQKYFNIDVL--VPP---------TIIGTNFPNE--- 1462

Query: 145  ARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEA-AEPRKKK 203
                           ++  +   V L+C   G P PDI W KD + L   +   E   + 
Sbjct: 1463 ---------------VSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRG 1507

Query: 204  WTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGT 263
              L LKN R  D G+Y C VSN AG      K+ +      K    G    + +V     
Sbjct: 1508 QVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIK---GGNVTTDISVLINSL 1564

Query: 264  TSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKL 323
               +C+ R    P I W K                 GQ   ++ +        G YL+  
Sbjct: 1565 IKLECETRGLPMPAITWYK----------------DGQP--IMSSSQALYIDKGQYLH-- 1604

Query: 324  LITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVI 381
             I RA+  D+  Y C  AN  G + +S  + V        PP+   + AT L   VVI
Sbjct: 1605 -IPRAQVSDSATYTCHVANVAGTAEKSFHVDVYV------PPMIEGNLATPLNKQVVI 1655



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 85/327 (25%), Positives = 127/327 (38%), Gaps = 56/327 (17%)

Query: 43   LGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--LKVKQVEREDAGVYVCK 100
            L     L C     PP    W KDG  + S     R+LP G  L++   + ++AG Y C 
Sbjct: 2589 LNSPTSLVCEAYSYPPATITWFKDGTPLESN-RNIRILPGGRTLQILNAQEDNAGRYSCV 2647

Query: 101  ATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVI 160
            ATN  G +  +Y + V          + P  + G    P            P +++ +V 
Sbjct: 2648 ATNEAGEMIKHYEVKVY---------IPPIINKGDLWGPG---------LSPKEVKIKV- 2688

Query: 161  ARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYT 220
                 +++ L+C A   P   ++W KD Q L   +         TL +K  +  D+G+YT
Sbjct: 2689 ----NNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYT 2744

Query: 221  CRVSNRAGAINATYKVDVIQRTRSKPVL--------TGTHPVNTTVDFGGTTSFQCKVRS 272
            C  SN AG     + V+ IQ   S   L        TG +     V      S  C+  +
Sbjct: 2745 CVASNIAGEDELDFDVN-IQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNA 2803

Query: 273  DVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDD 332
               P + W K      +G   ++ D    K ++LP G V           L I RA+ +D
Sbjct: 2804 APPPTLTWYK------DGHPLTSSD----KVLILPGGRV-----------LQIPRAKVED 2842

Query: 333  AGMYICLGANTMGYSFRSAFLTVLPDP 359
            AG Y C+  N  G       + VL  P
Sbjct: 2843 AGRYTCVAVNEAGEDSLQYDVRVLVPP 2869



 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 95/347 (27%), Positives = 133/347 (38%), Gaps = 68/347 (19%)

Query: 21   PAAAARGPPKMADKVVP-------RQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSG 73
            PA  A G  K+  +V P         V  + + + L C  +G PPP   W KDGR I   
Sbjct: 4063 PAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVES 4122

Query: 74   WSRFRVLPQG-LKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSS 132
              R RVL  G L++  V+  DAG Y C A N  GS S +  L V   + P          
Sbjct: 4123 -IRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTV--HVPP---------- 4169

Query: 133  SGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALT 192
                         R R T+              S   L CVA G P P I W KD+  L 
Sbjct: 4170 -------------RIRSTEGHYTVNE------NSQAILPCVADGIPTPAINWKKDNVLLA 4210

Query: 193  RPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTH 252
                    +    L L+N+  EDSG YTC  +N AG    T  + V       P  T   
Sbjct: 4211 NLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTV----HVLPTFTEL- 4265

Query: 253  PVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVW 312
            P + +++ G      CK      P + W            N+ I         +P    +
Sbjct: 4266 PGDVSLNKGEQLRLSCKATGIPLPKLTW----------TFNNNI---------IPAH--F 4304

Query: 313  SRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP 359
               +G   ++L+I R  ++D+G Y+C   N++G+     F+ V   P
Sbjct: 4305 DSVNGH--SELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPP 4349



 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 85/365 (23%), Positives = 141/365 (38%), Gaps = 72/365 (19%)

Query: 44   GRTVRLQCPV-EGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKVKQVEREDAGVYVCKA 101
            G+ + L C +  G+P P   W K+   +        V   G L +++V+ +D G Y C A
Sbjct: 904  GQQLTLPCTLLAGNPIPERRWIKNSAMLLQN-PYITVRSDGSLHIERVQLQDGGEYTCVA 962

Query: 102  TNGFGSLSVNYTLVV--LDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRV 159
            +N  G+ +   ++VV  L  I  G++                                 +
Sbjct: 963  SNVAGTNNKTTSVVVHVLPTIQHGQQ---------------------------------I 989

Query: 160  IARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKY 219
            ++   G  V L C ASG+P+P + W K  + ++   A        +L + +   E+SG+Y
Sbjct: 990  LSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEY 1049

Query: 220  TCRVSNRAGAINATYKVDVIQRTR---SKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKP 276
             C  +N AG      ++ V  R R    +  L+   PV  +V  G   +  C+V+S   P
Sbjct: 1050 VCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPP 1109

Query: 277  VIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMY 336
            +I W K  +          I     +   LP+G             + IT  R  D+GMY
Sbjct: 1110 IITWAKETQ---------LISPFSPRHTFLPSG------------SMKITETRTSDSGMY 1148

Query: 337  ICLGANTMGYSFRSAFLTVLPDPK----------PPGPPVASSSSATSLPWPVVIGIPAG 386
            +C+  N  G   ++  L V   PK            G  V    +A   P PV+     G
Sbjct: 1149 LCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGG 1208

Query: 387  AVFIL 391
            +  ++
Sbjct: 1209 STMLV 1213



 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 79/346 (22%), Positives = 127/346 (36%), Gaps = 53/346 (15%)

Query: 28   PPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--LK 85
            PP +           +   + L C V G PPP   W K+ + I    +   ++P G  L+
Sbjct: 2963 PPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTL-IVPGGRTLQ 3021

Query: 86   VKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWA 145
            + + +  D G Y C A N  G     ++L V   + P  +    +S S            
Sbjct: 3022 IIRAKVSDGGEYTCIAINQAGESKKKFSLTVY--VPPSIKDHDSESLS------------ 3067

Query: 146  RPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWT 205
                         V+    G+SV L+C ++  P P ITW K+ + +T     E       
Sbjct: 3068 -------------VVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQM 3114

Query: 206  LSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTS 265
            L +K     D+G+Y CR  N AG  +  + ++V       P + G              +
Sbjct: 3115 LHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVY----VPPSIEGPEREVIVETISNPVT 3170

Query: 266  FQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLI 325
              C       P I WLK         H    +    +  +L  G           +KL I
Sbjct: 3171 LTCDATGIPPPTIAWLK--------NHKRIENSDSLEVRILSGG-----------SKLQI 3211

Query: 326  TRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSS 371
             R++  D+G Y C+ +N  G + +  FL++   P   G  + S  S
Sbjct: 3212 ARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVS 3257



 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 72/325 (22%), Positives = 116/325 (35%), Gaps = 65/325 (20%)

Query: 43   LGRTVRLQCPVEGDPPPLTMWTKDGRTIHS----GWSRFRVLPQGLKVKQVEREDAGVYV 98
            + + V L C  +  PPP   W KDG  +        S  R +   LK++  + +D G Y 
Sbjct: 2117 ISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSV---LKIEDAQVQDTGRYT 2173

Query: 99   CKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRR 158
            C+ATN  G    NY + +                           W  P      ++ + 
Sbjct: 2174 CEATNVAGKTEKNYNVNI---------------------------WVPPNIGGSDELTQL 2206

Query: 159  VIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPR--KKKWTLSLKNLRPEDS 216
             +    G+ + L C +SG P P++ W K    +        R       L +      D+
Sbjct: 2207 TVIE--GNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDA 2264

Query: 217  GKYTCRVSNRAGAINATYKVDVIQRTRSKPVLT--GTHPVNTTVDFGGTTSFQCKVRSDV 274
              Y+C  SN AG     Y + V  R    P +T  G+HP    V  G + S +C+V+   
Sbjct: 2265 ALYSCVASNVAGTAKKEYNLQVYIR----PTITNSGSHPTEIIVTRGKSISLECEVQGIP 2320

Query: 275  KPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAG 334
             P + W+K      + +    +D G                     + L +      D G
Sbjct: 2321 PPTVTWMKDGHPLIKAKGVEILDEG---------------------HILQLKNIHVSDTG 2359

Query: 335  MYICLGANTMGYSFRSAFLTVLPDP 359
             Y+C+  N  G + +   L+V   P
Sbjct: 2360 RYVCVAVNVAGMTDKKYDLSVHAPP 2384



 Score = 79.7 bits (195), Expect = 6e-15
 Identities = 82/325 (25%), Positives = 125/325 (38%), Gaps = 57/325 (17%)

Query: 40   VARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWS-RFRVLPQG--LKVKQVEREDAGV 96
            V  +   V L C   G PPP   W K+ + I +  S   R+L  G  L++ + +  D+G 
Sbjct: 3162 VETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGN 3221

Query: 97   YVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMR 156
            Y C A+N  G     Y L           S+    S  G E P+                
Sbjct: 3222 YTCIASNMEGKAQKYYFL-----------SIQVPPSVAGAEIPSD--------------- 3255

Query: 157  RRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPR--KKKWTLSLKNLRPE 214
               ++  +G +V L C A+G P P I W+KD + +   E    R      TL++      
Sbjct: 3256 ---VSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTS 3312

Query: 215  DSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDV 274
            D+GKYTC  +N AG  +  + ++V      +        + T VD   + + +C+     
Sbjct: 3313 DTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVD--TSINIECRATGTP 3370

Query: 275  KPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAG 334
             P I WLK    G     +S I        +L  G V           + I RA+  D  
Sbjct: 3371 PPQINWLKN---GLPLPLSSHIR-------LLAAGQV-----------IRIVRAQVSDVA 3409

Query: 335  MYICLGANTMGYSFRSAFLTVLPDP 359
            +Y C+ +N  G   +   L V   P
Sbjct: 3410 VYTCVASNRAGVDNKHYNLQVFAPP 3434



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 86/367 (23%), Positives = 136/367 (37%), Gaps = 67/367 (18%)

Query: 28   PPKMADKVVPRQVARL-GRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRV-LPQGLK 85
            PP +    V   ++ L    ++L+C   G P P   W KDG+ I S      +   Q L 
Sbjct: 1545 PPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLH 1604

Query: 86   VKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWA 145
            + + +  D+  Y C   N  G+   ++ + V            P    G    P ++Q  
Sbjct: 1605 IPRAQVSDSATYTCHVANVAGTAEKSFHVDV----------YVPPMIEGNLATPLNKQVV 1654

Query: 146  RPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWT 205
                              +  S+ L+C A+G+P P +TW+KD   +   +          
Sbjct: 1655 ------------------IAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKK 1696

Query: 206  LSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVN-TTVDFGGTT 264
            L + + +  D G+Y C  ++ AG     Y+VDV+      P + G    +   V      
Sbjct: 1697 LEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVL----VPPAIEGGDETSYFIVMVNNLL 1752

Query: 265  SFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLL 324
               C V     P I WLK      +G+     D     F +L  G            KL+
Sbjct: 1753 ELDCHVTGSPPPTIMWLK------DGQLIDERD----GFKILLNG-----------RKLV 1791

Query: 325  ITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDP--KPPG---------PPVASSSSAT 373
            I +A+  + G+Y C+ ANT G   +   +TV   P  K  G          PVA    A 
Sbjct: 1792 IAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIAN 1851

Query: 374  SLPWPVV 380
             +P P +
Sbjct: 1852 GIPNPSI 1858



 Score = 76.3 bits (186), Expect = 6e-14
 Identities = 92/365 (25%), Positives = 132/365 (36%), Gaps = 64/365 (17%)

Query: 28   PPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKV 86
            PP +AD+     V +    V + C   G P P   WTK+G  +      +R+L  G +++
Sbjct: 3896 PPSIADEPTDFLVTKHAPAV-ITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEI 3954

Query: 87   KQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWAR 146
               +   AG Y C A N  GS   + TL V +                            
Sbjct: 3955 LATQLNHAGRYTCVARNAAGSAHRHVTLHVHE---------------------------- 3986

Query: 147  PRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTL 206
            P   QP      VI   + + + L C A+G P P ITW K+   +              L
Sbjct: 3987 PPVIQPQPSELHVI---LNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGGL 4043

Query: 207  SLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSF 266
             +     ED+G Y C   N AG      K++V       P +   H     +      + 
Sbjct: 4044 QISRAVREDAGTYMCVAQNPAGTALGKIKLNV-----QVPPVISPHLKEYVIAVDKPITL 4098

Query: 267  QCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLIT 326
             C+      P I W K      +GR  + ++   Q+  VL +G             L I 
Sbjct: 4099 SCEADGLPPPDITWHK------DGR--AIVESIRQR--VLSSG------------SLQIA 4136

Query: 327  RARQDDAGMYICLGANTMGYSFRSAFLTVLPDPK---PPGPPVASSSSATSLPWPVVIGI 383
              +  DAG Y C+ AN  G S  S  LTV   P+     G    + +S   LP  V  GI
Sbjct: 4137 FVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPC-VADGI 4195

Query: 384  PAGAV 388
            P  A+
Sbjct: 4196 PTPAI 4200



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 68/303 (22%), Positives = 115/303 (37%), Gaps = 61/303 (20%)

Query: 44   GRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKATN 103
            G  +RL C   G P P   WT +   I + +       + L +++V +ED+G YVC A N
Sbjct: 4274 GEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSE-LVIERVSKEDSGTYVCTAEN 4332

Query: 104  GFGSL-SVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIAR 162
              G + ++ +  V    +  G                            PS         
Sbjct: 4333 SVGFVKAIGFVYVKEPPVFKGD--------------------------YPSNW-----IE 4361

Query: 163  PVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCR 222
            P+G +  L C   G P P I W +    +        +    +L++     ED+G YTC 
Sbjct: 4362 PLGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIR-QLGNGSLAIYGTVNEDAGDYTCV 4420

Query: 223  VSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLK 282
             +N AG +  +  + +    +S P++T   PV T ++ GG     C+   + +P I W +
Sbjct: 4421 ATNEAGVVERSMSLTL----QSPPIIT-LEPVETVINAGGKIILNCQATGEPQPTITWSR 4475

Query: 283  RVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGAN 342
            +        H+ + D                R +    N L I  A+++D   + C+  N
Sbjct: 4476 Q-------GHSISWD---------------DRVNVLSNNSLYIADAQKEDTSEFECVARN 4513

Query: 343  TMG 345
             MG
Sbjct: 4514 LMG 4516



 Score = 73.9 bits (180), Expect = 3e-13
 Identities = 75/334 (22%), Positives = 122/334 (36%), Gaps = 51/334 (15%)

Query: 37   PRQVA-RLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG--LKVKQVERED 93
            P++V  ++  T+ L+C     P     W KDG+ + S      +   G  L++K+ +  D
Sbjct: 2681 PKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSD-DHVNIAANGHTLQIKEAQISD 2739

Query: 94   AGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPS 153
             G Y C A+N  G   +++ + +   + P  + L      G   D      A+       
Sbjct: 2740 TGRYTCVASNIAGEDELDFDVNI--QVPPSFQKLW---EIGNMLDTGRNGEAKDVI---- 2790

Query: 154  KMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRP 213
                      + + + L C  +  P P +TW KD   LT  +          L +   + 
Sbjct: 2791 ----------INNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKV 2840

Query: 214  EDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTH---PVNTTVDFGGTTSFQCKV 270
            ED+G+YTC   N AG  +  Y V V+      P++ G +   P   TV    +   +C  
Sbjct: 2841 EDAGRYTCVAVNEAGEDSLQYDVRVL----VPPIIKGANSDLPEEVTVLVNKSALIECLS 2896

Query: 271  RSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQ 330
                 P   W K  +   E  H+  +  G                       L I   + 
Sbjct: 2897 SGSPAPRNSWQKDGQPLLEDDHHKFLSNG---------------------RILQILNTQI 2935

Query: 331  DDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGP 364
             D G Y+C+  NT G + +   L V   P   GP
Sbjct: 2936 TDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGP 2969



 Score = 72.8 bits (177), Expect = 7e-13
 Identities = 68/297 (22%), Positives = 113/297 (38%), Gaps = 45/297 (15%)

Query: 28  PPKMADKVVPRQVARLGRT-VRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LK 85
           PPK+   V+P+  +  G + V + C   G P P   WT +   I  G  R+R+   G L 
Sbjct: 611 PPKVT--VMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFI-VGSHRYRMTSDGTLF 667

Query: 86  VKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWA 145
           +K    +DAG+Y C A+N  G+   N TL                               
Sbjct: 668 IKNAAPKDAGIYGCLASNSAGTDKQNSTL------------------------------- 696

Query: 146 RPRFTQPSKMR--RRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKK 203
             R+ +  K+   +  +   +G    ++C  SG P P + W K D  L            
Sbjct: 697 --RYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLL 754

Query: 204 WTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGT 263
             L ++  +  D+G YTC   N AG       +DV       P +    P + +++ G  
Sbjct: 755 GLLKIQETQDLDAGDYTCVAINEAGRATGKITLDV-----GSPPVFIQEPADVSMEIGSN 809

Query: 264 TSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYL 320
            +  C V+   +P I+W +        R  S   +   +   L   ++W+   G+Y+
Sbjct: 810 VTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYI 866



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 66/304 (21%), Positives = 107/304 (35%), Gaps = 54/304 (17%)

Query: 43   LGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWS-RFRVLPQGLKVKQVEREDAGVYVCKA 101
            +  ++ L+C   G+P P+  W KDG  + +  + R     + L++   +  D G Y+C A
Sbjct: 1655 IAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVA 1714

Query: 102  TNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIA 161
            T+  G   + Y + VL           P +  GG E                        
Sbjct: 1715 TSVAGEKEIKYEVDVLV----------PPAIEGGDETS-------------------YFI 1745

Query: 162  RPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTC 221
              V + + L C  +G P P I W+KD Q +   +  +       L +   +  ++G Y C
Sbjct: 1746 VMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRC 1805

Query: 222  RVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWL 281
              +N AG     ++V V       P +  +      V      + QC       P I WL
Sbjct: 1806 MAANTAGDHKKEFEVTV----HVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWL 1861

Query: 282  KRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGA 341
            K  +     + N  I   G+                     L I +   +DAG Y C+  
Sbjct: 1862 KDDQPVNTAQGNLKIQSSGR--------------------VLQIAKTLLEDAGRYTCVAT 1901

Query: 342  NTMG 345
            N  G
Sbjct: 1902 NAAG 1905



 Score = 70.1 bits (170), Expect = 4e-12
 Identities = 90/357 (25%), Positives = 132/357 (36%), Gaps = 76/357 (21%)

Query: 43   LGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGL---KVKQVEREDAGVYVC 99
            LG    ++C   G PPP   W K    +    S F ++   L   K+++ +  DAG Y C
Sbjct: 715  LGDITVMECKTSGIPPPQVKWFKGDLELRP--STFLIIDPLLGLLKIQETQDLDAGDYTC 772

Query: 100  KATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRV 159
             A N  G  +             GK +L   S     ++PA                   
Sbjct: 773  VAINEAGRAT-------------GKITLDVGSPPVFIQEPAD------------------ 801

Query: 160  IARPVGSSVRLKCVASGHPRPDITWMKDDQ--ALTRPEAAE--PRKKKWTLSLKNLRPED 215
            ++  +GS+V L C   G+P P I W + D     +RP +     + +   L + NL   D
Sbjct: 802  VSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASD 861

Query: 216  SGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCK-VRSDV 274
             G Y C   N+ G I +   V V   T     L G  P    V  G   +  C  +  + 
Sbjct: 862  KGTYICEAENQFGKIQSETTVTV---TGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNP 918

Query: 275  KPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAG 334
             P  +W+K          NS         ++L    +  R DGS    L I R +  D G
Sbjct: 919  IPERRWIK----------NSA--------MLLQNPYITVRSDGS----LHIERVQLQDGG 956

Query: 335  MYICLGANTMGYSFR--SAFLTVLPDPKP--------PGPPVASSSSATSLPWPVVI 381
             Y C+ +N  G + +  S  + VLP  +          G PV     A+  P P VI
Sbjct: 957  EYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVI 1013



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 81/345 (23%), Positives = 124/345 (35%), Gaps = 79/345 (22%)

Query: 63  WTKDGRTIHSGW-SRFRVLPQ-GLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDI 120
           W ++ R +     +R R L    L++K V+  DAG Y C  ++  GS + +  L V +  
Sbjct: 553 WQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQE-- 610

Query: 121 SPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRP 180
            P K ++ P + S               FT              GS V + C A+G+P+P
Sbjct: 611 -PPKVTVMPKNQS---------------FTG-------------GSEVSIMCSATGYPKP 641

Query: 181 DITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQ 240
            I W  +D  +             TL +KN  P+D+G Y C  SN AG       +  I+
Sbjct: 642 KIAWTVNDMFIVGSHRYR-MTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIE 700

Query: 241 RTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGG 300
             +   V +        V  G  T  +CK      P ++W K             +++  
Sbjct: 701 APKLMVVQS-----ELLVALGDITVMECKTSGIPPPQVKWFK-----------GDLELRP 744

Query: 301 QKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPK 360
             F+++             L  L I   +  DAG Y C+  N  G +     L V     
Sbjct: 745 STFLII----------DPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDV----- 789

Query: 361 PPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWLCQAQKKP 405
             G P            PV I  PA     +G+ +   C  Q  P
Sbjct: 790 --GSP------------PVFIQEPADVSMEIGSNVTLPCYVQGYP 820



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 50/204 (24%), Positives = 77/204 (37%), Gaps = 34/204 (16%)

Query: 28   PPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKV 86
            PP          +  LG    L C V+GDP P   W + G  I     R R L  G L +
Sbjct: 4348 PPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRKGVDIEIS-HRIRQLGNGSLAI 4406

Query: 87   KQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWAR 146
                 EDAG Y C ATN  G +  + +L +    SP   +L P  +              
Sbjct: 4407 YGTVNEDAGDYTCVATNEAGVVERSMSLTLQ---SPPIITLEPVET-------------- 4449

Query: 147  PRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTL 206
                              G  + L C A+G P+P ITW +   +++  +         +L
Sbjct: 4450 --------------VINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNN-SL 4494

Query: 207  SLKNLRPEDSGKYTCRVSNRAGAI 230
             + + + ED+ ++ C   N  G++
Sbjct: 4495 YIADAQKEDTSEFECVARNLMGSV 4518



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 49/197 (24%), Positives = 78/197 (39%), Gaps = 28/197 (14%)

Query: 165 GSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRK-KKWTLSLKNLRPEDSGKYTCRV 223
           G    L C+       ++TW ++D+ +   E A  R     +L LK+++  D+G+Y C V
Sbjct: 534 GERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMV 593

Query: 224 SNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKR 283
           S+  G+  A+     +  T  +P      P N +   G   S  C      KP I W   
Sbjct: 594 SSEGGSSAAS-----VFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTV- 647

Query: 284 VEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANT 343
                    N    VG  ++ +   G             L I  A   DAG+Y CL +N+
Sbjct: 648 ---------NDMFIVGSHRYRMTSDG------------TLFIKNAAPKDAGIYGCLASNS 686

Query: 344 MGYSFRSAFLTVLPDPK 360
            G   +++ L  +  PK
Sbjct: 687 AGTDKQNSTLRYIEAPK 703



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 24/78 (30%), Positives = 36/78 (46%), Gaps = 2/78 (2%)

Query: 40   VARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLP-QGLKVKQVEREDAGVYV 98
            V   G  + L C   G+P P   W++ G +I S   R  VL    L +   ++ED   + 
Sbjct: 4450 VINAGGKIILNCQATGEPQPTITWSRQGHSI-SWDDRVNVLSNNSLYIADAQKEDTSEFE 4508

Query: 99   CKATNGFGSLSVNYTLVV 116
            C A N  GS+ V   ++V
Sbjct: 4509 CVARNLMGSVLVRVPVIV 4526


>gi|222144233 fibroblast growth factor receptor 2 isoform 4
           precursor [Homo sapiens]
          Length = 709

 Score =  103 bits (256), Expect = 5e-22
 Identities = 66/235 (28%), Positives = 116/235 (49%), Gaps = 9/235 (3%)

Query: 40  VARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVL-PQGLKVKQVEREDAGVYV 98
           VA  G ++ ++C ++     +  WTKDG  +H G +   VL  + L++K     D+G+Y 
Sbjct: 51  VAAPGESLEVRCLLKD--AAVISWTKDG--VHLGPNNRTVLIGEYLQIKGATPRDSGLYA 106

Query: 99  CKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRR 158
           C A+    S +  + + V D IS G +    D +     + ++ + A P +T   KM +R
Sbjct: 107 CTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA-PYWTNTEKMEKR 165

Query: 159 VIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAA---EPRKKKWTLSLKNLRPED 215
           + A P  ++V+ +C A G+P P + W+K+ +   +       + R + W+L ++++ P D
Sbjct: 166 LHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSD 225

Query: 216 SGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKV 270
            G YTC V N  G+IN TY +DV+   R K +      +   +   G     C V
Sbjct: 226 KGNYTCVVENEYGSINHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLIACMV 280



 Score = 37.7 bits (86), Expect = 0.025
 Identities = 69/311 (22%), Positives = 107/311 (34%), Gaps = 67/311 (21%)

Query: 126 SLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWM 185
           SL  D++   +E P   Q ++P            +A P G S+ ++C+        I+W 
Sbjct: 26  SLVEDTTLEPEEPPTKYQISQPEV---------YVAAP-GESLEVRCLLKD--AAVISWT 73

Query: 186 KDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRS- 244
           KD   L  P        ++ L +K   P DSG Y C  S    +    + V+V     S 
Sbjct: 74  KDGVHLG-PNNRTVLIGEY-LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSG 131

Query: 245 ---------------------KPVLTGTHPVNT---TVDFGGTTSFQCKVRSDVKPVIQW 280
                                 P  T T  +      V    T  F+C    +  P ++W
Sbjct: 132 DDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRW 191

Query: 281 LKR-VEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICL 339
           LK   E+  E R      +GG K         WS         L++      D G Y C+
Sbjct: 192 LKNGKEFKQEHR------IGGYKV----RNQHWS---------LIMESVVPSDKGNYTCV 232

Query: 340 GANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWLC 399
             N  G    +  L V+     PG         T+ P  + I I    VF++  +++ + 
Sbjct: 233 VENEYGSINHTYHLDVV----APG----REKEITASPDYLEIAIYCIGVFLIACMVVTVI 284

Query: 400 QAQKKPCTPAP 410
             + K  T  P
Sbjct: 285 LCRMKNTTKKP 295


>gi|224994173 roundabout 1 isoform d [Homo sapiens]
          Length = 1551

 Score =  101 bits (252), Expect = 1e-21
 Identities = 90/329 (27%), Positives = 122/329 (37%), Gaps = 62/329 (18%)

Query: 43  LGRTVRLQC-PVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKA 101
           +G    ++C P  G P P   W KDG  +     R  +    L +    + DAG YVC  
Sbjct: 144 VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVG 203

Query: 102 TNGFGSLSVNYT-LVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVI 160
           TN  G        L VL+                           RP F +    R   +
Sbjct: 204 TNMVGERESEVAELTVLE---------------------------RPSFVK----RPSNL 232

Query: 161 ARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYT 220
           A  V  S   KC A G P P + W KDD  L  P++    +   TL ++ +   D G YT
Sbjct: 233 AVTVDDSAEFKCEARGDPVPTVRWRKDDGEL--PKSRYEIRDDHTLKIRKVTAGDMGSYT 290

Query: 221 CRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQW 280
           C   N  G   A+  + V  +  S+P      P +  V  G T +FQC+   + +P I W
Sbjct: 291 CVAENMVGKAEASATLTV--QVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFW 348

Query: 281 LKRVEYGAEGRHNSTIDV----GGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMY 336
            +      EG  N            +F V  TGD            L IT  ++ D G Y
Sbjct: 349 RR------EGSQNLLFSYQPPQSSSRFSVSQTGD------------LTITNVQRSDVGYY 390

Query: 337 ICLGANTMGYSFRSAFL---TVLPDPKPP 362
           IC   N  G     A+L    V+ D  PP
Sbjct: 391 ICQTLNVAGSIITKAYLEVTDVIADRPPP 419



 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 90/330 (27%), Positives = 128/330 (38%), Gaps = 62/330 (18%)

Query: 46  TVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG-LKVKQVEREDAGVYVCKATNG 104
           +   +C   GDP P   W KD   +    SR+ +     LK+++V   D G Y C A N 
Sbjct: 239 SAEFKCEARGDPVPTVRWRKDDGELPK--SRYEIRDDHTLKIRKVTAGDMGSYTCVAENM 296

Query: 105 FGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPV 164
            G    + TL V     P                        P F    K R +V+A  +
Sbjct: 297 VGKAEASATLTVQVGSEP------------------------PHFV--VKPRDQVVA--L 328

Query: 165 GSSVRLKCVASGHPRPDITWMKD-DQALT---RPEAAEPR---KKKWTLSLKNLRPEDSG 217
           G +V  +C A+G+P+P I W ++  Q L    +P  +  R    +   L++ N++  D G
Sbjct: 329 GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVG 388

Query: 218 KYTCRVSNRAGAI--NATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVK 275
            Y C+  N AG+I   A  +V  +   R  PV+    PVN TV   GT    C       
Sbjct: 389 YYICQTLNVAGSIITKAYLEVTDVIADRPPPVIR-QGPVNQTVAVDGTFVLSCVATGSPV 447

Query: 276 PVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGM 335
           P I W K      +G   ST D               SR        L I  A+  D G 
Sbjct: 448 PTILWRK------DGVLVSTQD---------------SRIKQLENGVLQIRYAKLGDTGR 486

Query: 336 YICLGANTMGYSFRSAFLTVLPDPKPPGPP 365
           Y C+ +   G +  SA++ V     P  PP
Sbjct: 487 YTCIASTPSGEATWSAYIEVQEFGVPVQPP 516



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 98/381 (25%), Positives = 137/381 (35%), Gaps = 90/381 (23%)

Query: 28  PPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSG----WSRFRVLPQG 83
           PP++ +      V++ G    L C  EG P P   W K G  + +      S   +LP G
Sbjct: 28  PPRIVEHPSDLIVSK-GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86

Query: 84  ----LKV--KQVEREDAGVYVCKATNGFG-SLSVNYTL---VVLDDISPGKESLGPDSSS 133
               L++   +  R D GVYVC A N  G ++S N +L   ++ DD         P    
Sbjct: 87  SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQ-----NPSDVM 141

Query: 134 GGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQAL-T 192
               +PA  +   PR                           GHP P I+W KD   L  
Sbjct: 142 VAVGEPAVMECQPPR---------------------------GHPEPTISWKKDGSPLDD 174

Query: 193 RPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTH 252
           + E    R  K  L +   R  D+GKY C  +N  G   +    +V + T  +       
Sbjct: 175 KDERITIRGGK--LMITYTRKSDAGKYVCVGTNMVGERES----EVAELTVLERPSFVKR 228

Query: 253 PVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVW 312
           P N  V    +  F+C+ R D  P ++W K              D G      LP     
Sbjct: 229 PSNLAVTVDDSAEFKCEARGDPVPTVRWRK--------------DDG-----ELPKSRYE 269

Query: 313 SRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPP---------- 362
            R D    + L I +    D G Y C+  N +G +  SA LTV    +PP          
Sbjct: 270 IRDD----HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQV 325

Query: 363 ---GPPVASSSSATSLPWPVV 380
              G  V     AT  P P +
Sbjct: 326 VALGRTVTFQCEATGNPQPAI 346



 Score = 76.3 bits (186), Expect = 6e-14
 Identities = 60/213 (28%), Positives = 90/213 (42%), Gaps = 34/213 (15%)

Query: 35  VVPR-QVARLGRTVRLQCPVEGDPPPLTMWTKDGR-------TIHSGWSRFRVLPQG-LK 85
           V PR QV  LGRTV  QC   G+P P   W ++G              SRF V   G L 
Sbjct: 319 VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT 378

Query: 86  VKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWA 145
           +  V+R D G Y+C+  N  GS+     L V D I+     +        ++ P +Q  A
Sbjct: 379 ITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV-------IRQGPVNQTVA 431

Query: 146 RPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWT 205
                             V  +  L CVA+G P P I W KD   ++  ++   + +   
Sbjct: 432 ------------------VDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGV 473

Query: 206 LSLKNLRPEDSGKYTCRVSNRAGAINATYKVDV 238
           L ++  +  D+G+YTC  S  +G    +  ++V
Sbjct: 474 LQIRYAKLGDTGRYTCIASTPSGEATWSAYIEV 506



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 29/84 (34%), Positives = 40/84 (47%), Gaps = 2/84 (2%)

Query: 24  AARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQG 83
           A R PP +    V + VA  G  V L C   G P P  +W KDG  + +  SR + L  G
Sbjct: 414 ADRPPPVIRQGPVNQTVAVDGTFV-LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG 472

Query: 84  -LKVKQVEREDAGVYVCKATNGFG 106
            L+++  +  D G Y C A+   G
Sbjct: 473 VLQIRYAKLGDTGRYTCIASTPSG 496


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.136    0.429 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,920,218
Number of Sequences: 37866
Number of extensions: 1527725
Number of successful extensions: 16555
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 315
Number of HSP's successfully gapped in prelim test: 384
Number of HSP's that attempted gapping in prelim test: 9122
Number of HSP's gapped (non-prelim): 4686
length of query: 504
length of database: 18,247,518
effective HSP length: 107
effective length of query: 397
effective length of database: 14,195,856
effective search space: 5635754832
effective search space used: 5635754832
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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