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Search of human proteins with 5174677
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5174677 ST8 alpha-N-acetyl-neuraminide
alpha-2,8-sialyltransferase 2 [Homo sapiens]
(375 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5174677 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransf... 759 0.0
gi|5031999 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransf... 427 e-120
gi|110815855 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltran... 237 1e-62
gi|4506953 alpha-2,8-sialyltransferase 1 [Homo sapiens] 175 5e-44
gi|28373101 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltrans... 160 1e-39
gi|28373099 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltrans... 150 2e-36
gi|54234057 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltrans... 149 4e-36
gi|21264332 sialyltransferase 7A [Homo sapiens] 79 5e-15
gi|109633046 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 ... 73 5e-13
gi|109633044 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 ... 73 5e-13
gi|5902082 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 [H... 73 5e-13
gi|13569938 sialyltransferase 7E [Homo sapiens] 72 8e-13
gi|5454058 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 [H... 65 1e-10
gi|28373086 sialyltransferase 6 isoform i [Homo sapiens] 64 2e-10
gi|28373082 sialyltransferase 6 isoform g [Homo sapiens] 64 2e-10
gi|28373078 sialyltransferase 6 isoform f [Homo sapiens] 64 2e-10
gi|28373070 sialyltransferase 6 isoform b [Homo sapiens] 64 2e-10
gi|28373068 sialyltransferase 6 isoform a [Homo sapiens] 64 2e-10
gi|5454060 sialyltransferase 6 isoform j [Homo sapiens] 64 2e-10
gi|5174697 alpha2,3-sialyltransferase VI [Homo sapiens] 64 2e-10
gi|215272345 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2... 62 8e-10
gi|26190610 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 ... 62 8e-10
gi|27765096 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 [... 61 2e-09
gi|4506951 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 [H... 61 2e-09
gi|192448440 sialyltransferase 7B [Homo sapiens] 60 4e-09
gi|4506949 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 i... 60 4e-09
gi|27765091 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 ... 60 4e-09
gi|215272347 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2... 59 9e-09
gi|28373074 sialyltransferase 6 isoform d [Homo sapiens] 55 1e-07
gi|28373092 sialyltransferase 7D isoform a [Homo sapiens] 49 7e-06
>gi|5174677 ST8 alpha-N-acetyl-neuraminide
alpha-2,8-sialyltransferase 2 [Homo sapiens]
Length = 375
Score = 759 bits (1960), Expect = 0.0
Identities = 375/375 (100%), Positives = 375/375 (100%)
Query: 1 MQLQFRSWMLAALTLLVVFLIFADISEIEEEIGNSGGRGTIRSAVNSLHSKSNRAEVVIN 60
MQLQFRSWMLAALTLLVVFLIFADISEIEEEIGNSGGRGTIRSAVNSLHSKSNRAEVVIN
Sbjct: 1 MQLQFRSWMLAALTLLVVFLIFADISEIEEEIGNSGGRGTIRSAVNSLHSKSNRAEVVIN 60
Query: 61 GSSSPAVVDRSNESIKHNIQPASSKWRHNQTLSLRIRKQILKFLDAEKDISVLKGTLKPG 120
GSSSPAVVDRSNESIKHNIQPASSKWRHNQTLSLRIRKQILKFLDAEKDISVLKGTLKPG
Sbjct: 61 GSSSPAVVDRSNESIKHNIQPASSKWRHNQTLSLRIRKQILKFLDAEKDISVLKGTLKPG 120
Query: 121 DIIHYIFDRDSTMNVSQNLYELLPRTSPLKNKHFGTCAIVGNSGVLLNSGCGQEIDAHSF 180
DIIHYIFDRDSTMNVSQNLYELLPRTSPLKNKHFGTCAIVGNSGVLLNSGCGQEIDAHSF
Sbjct: 121 DIIHYIFDRDSTMNVSQNLYELLPRTSPLKNKHFGTCAIVGNSGVLLNSGCGQEIDAHSF 180
Query: 181 VIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLHSLNGSILWI 240
VIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLHSLNGSILWI
Sbjct: 181 VIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLHSLNGSILWI 240
Query: 241 PAFMARGGKERVEWVNELILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMY 300
PAFMARGGKERVEWVNELILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMY
Sbjct: 241 PAFMARGGKERVEWVNELILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMY 300
Query: 301 TLATRFCKQIYLYGFWPFPLDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFKALKSLHE 360
TLATRFCKQIYLYGFWPFPLDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFKALKSLHE
Sbjct: 301 TLATRFCKQIYLYGFWPFPLDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFKALKSLHE 360
Query: 361 QGALKLTVGQCDGAT 375
QGALKLTVGQCDGAT
Sbjct: 361 QGALKLTVGQCDGAT 375
>gi|5031999 ST8 alpha-N-acetyl-neuraminide
alpha-2,8-sialyltransferase 4 isoform a [Homo sapiens]
Length = 359
Score = 427 bits (1099), Expect = e-120
Identities = 211/371 (56%), Positives = 267/371 (71%), Gaps = 25/371 (6%)
Query: 6 RSWMLAALTLLVVFLIFADISEIEE----EIGNSGGRGTIRSAVNSLHSKSNRAEVVING 61
+ W + ++LL++F +I+ EE ++ G RS VNS
Sbjct: 6 KRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELSLSRSLVNS-------------- 51
Query: 62 SSSPAVVDRSNESI-KHNIQPASSKWRHNQTLSLRIRKQILKFLDAEKDISVLKGTLKPG 120
S ++ ++ SI +HN++ W+ N +L L IRK IL+FLDAE+D+SV+K + KPG
Sbjct: 52 --SDKIIRKAGSSIFQHNVEG----WKINSSLVLEIRKNILRFLDAERDVSVVKSSFKPG 105
Query: 121 DIIHYIFDRDSTMNVSQNLYELLPRTSPLKNKHFGTCAIVGNSGVLLNSGCGQEIDAHSF 180
D+IHY+ DR T+N+S +L+ LLP SP+KN+ F TCA+VGNSG+LL+S CG+EID+H+F
Sbjct: 106 DVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNF 165
Query: 181 VIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLHSLNGSILWI 240
VIRCNLAPV E+A DVG K+D +TMNPSV+QRAF N + REK + RL LN S+LWI
Sbjct: 166 VIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWI 225
Query: 241 PAFMARGGKERVEWVNELILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMY 300
PAFM +GG++ VEWVN LILK+ + VRTAYPSLRL+HAVRGYWLTNKV IKRP+TGLLMY
Sbjct: 226 PAFMVKGGEKHVEWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMY 285
Query: 301 TLATRFCKQIYLYGFWPFPLDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFKALKSLHE 360
TLATRFC +I+LYGFWPFP D N VKYHYYD LKY Y S ASPH MPLEFK L LH
Sbjct: 286 TLATRFCDEIHLYGFWPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVLHN 345
Query: 361 QGALKLTVGQC 371
+GALKLT G+C
Sbjct: 346 RGALKLTTGKC 356
>gi|110815855 ST8 alpha-N-acetyl-neuraminide
alpha-2,8-sialyltransferase 3 [Homo sapiens]
Length = 380
Score = 237 bits (604), Expect = 1e-62
Identities = 121/312 (38%), Positives = 183/312 (58%), Gaps = 7/312 (2%)
Query: 65 PAVVDRSNESIKHNIQPASSKWRHNQTLSLRIRKQILKFLDAEKDISVLKGTLKPGDIIH 124
P+ V +N S+ +Q SKW+ N+T L R++IL+ +D K+ S+ K +++ G ++H
Sbjct: 70 PSFVPITN-SLTQELQEKPSKWKFNRTAFLHQRQEILQHVDVIKNFSLTKNSVRIGQLMH 128
Query: 125 YIFDRDS-TMNVSQNLYELLPRTSPLKNKHFGTCAIVGNSGVLLNSGCGQEIDAHSFVIR 183
Y + ++S N LLP SP+ NKH+ CA+VGNSG+L S CGQEID FV R
Sbjct: 129 YDYSSHKYVFSISNNFRSLLPDVSPIMNKHYNICAVVGNSGILTGSQCGQEIDKSDFVFR 188
Query: 184 CNLAPVQEYARDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLHSLNGSILWIPAF 243
CN AP + + RDVG KT+L T NPS++++ + +L+ R L L+G+ILWIPAF
Sbjct: 189 CNFAPTEAFQRDVGRKTNLTTFNPSILEKYYNNLLTIQDRNNFFLSLKKLDGAILWIPAF 248
Query: 244 MARGGKERVEWVNELILKH--HVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYT 301
+ + ++H + V+ A+P ++ V YW + KR +TG+LMYT
Sbjct: 249 FFHTSATVTRTLVDFFVEHRGQLKVQLAWPG-NIMQHVNRYWKNKHLSPKRLSTGILMYT 307
Query: 302 LATRFCKQIYLYGFWPFPLDQN-QNPVKYHYYDSLKYGYTSQ-ASPHTMPLEFKALKSLH 359
LA+ C++I+LYGFWPF D N + + YHYYD +T++ H +P EF+ L +H
Sbjct: 308 LASAICEEIHLYGFWPFGFDPNTREDLPYHYYDKKGTKFTTKWQESHQLPAEFQLLYRMH 367
Query: 360 EQGALKLTVGQC 371
+G KLT+ C
Sbjct: 368 GEGLTKLTLSHC 379
>gi|4506953 alpha-2,8-sialyltransferase 1 [Homo sapiens]
Length = 356
Score = 175 bits (444), Expect = 5e-44
Identities = 96/304 (31%), Positives = 163/304 (53%), Gaps = 10/304 (3%)
Query: 71 SNESIKHNIQPASSKWRHNQTLSLRIRKQILKFLDAEKDISVLKGTLKPGDIIHYIFDRD 130
+ + I + + WR NQT + RKQ+ D ++ K G + Y +
Sbjct: 53 NEKEIVQGVLQQGTAWRRNQTAARAFRKQMEDCCDPAHLFAMTKMNSPMGKSMWYDGEFL 112
Query: 131 STMNVSQNLYELLPRTSPLKNKHFGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQ 190
+ + + Y L P+ +P + CA+VGN G+L SGCG++ID +FV+RCNL P+
Sbjct: 113 YSFTIDNSTYSLFPQATPFQLP-LKKCAVVGNGGILKKSGCGRQIDEANFVMRCNLPPLS 171
Query: 191 -EYARDVGLKTDLVTMNPSVIQRAFEDLVNATW-REKLLQRLHSLNGSILWIPAFMARGG 248
EY +DVG K+ LVT NPS+I++ F++L+ W R+ + + N S +++PAF + G
Sbjct: 172 SEYTKDVGSKSQLVTANPSIIRQRFQNLL---WSRKTFVDNMKIYNHSYIYMPAFSMKTG 228
Query: 249 KERVEWVNELILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCK 308
E V + N + + L ++ +W + +H KR +TGL + + A C+
Sbjct: 229 TEPSLRVYYTLSDVGANQTVLFANPNFLRSIGKFWKSRGIHAKRLSTGLFLVSAALGLCE 288
Query: 309 QIYLYGFWPFPLDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFKALKSLHEQGALKLTV 368
++ +YGFWPF ++ ++ P+ +HYYD++ + H MP EF L LH+ GAL++ +
Sbjct: 289 EVAIYGFWPFSVNMHEQPISHHYYDNV----LPFSGFHAMPEEFLQLWYLHKIGALRMQL 344
Query: 369 GQCD 372
C+
Sbjct: 345 DPCE 348
>gi|28373101 ST8 alpha-N-acetyl-neuraminide
alpha-2,8-sialyltransferase 5 [Homo sapiens]
Length = 376
Score = 160 bits (406), Expect = 1e-39
Identities = 90/288 (31%), Positives = 145/288 (50%), Gaps = 7/288 (2%)
Query: 85 KWRHNQTLSLRIRKQILKFLDAEKDISVLKGTLKPGDIIHYIFDRDSTMNVSQNLYELLP 144
KW N + + + + + + +A + + G + Y D +++Q ++ + P
Sbjct: 92 KWAMNISEANQFKSTLSRCCNAPAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFP 151
Query: 145 RTSPLKNKHFGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQE-YARDVGLKTDLV 203
+ P F CA+VGN G+L NS CG+EI++ FV RCNL P+ E Y DVG+KTD+V
Sbjct: 152 KDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEKYTMDVGVKTDVV 211
Query: 204 TMNPSVIQRAFEDLVNATWREKLLQRLHSLNGSILWIPAFMARGGKERVEWVNELILKHH 263
T+NPS+I F L WR + L + + +PAF + V ++
Sbjct: 212 TVNPSIITERFHKL--EKWRRPFYRVLQVYENASVLLPAFYNTRNTDVSIRVKYVLDDFE 269
Query: 264 VNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCKQIYLYGFWPFPLDQN 323
Y + L V YWL+ V KR +TGL++ T A C++++L+GFW FP++ +
Sbjct: 270 SPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPS 329
Query: 324 QNPVKYHYYDSLKYGYTSQASPHTMPLEFKALKSLHEQGALKLTVGQC 371
+ +HYYD++K + H MP E LH +G L++ G C
Sbjct: 330 GLYITHHYYDNVK----PRPGFHAMPSEIFNFLHLHSRGILRVHTGTC 373
>gi|28373099 ST8 alpha-N-acetyl-neuraminide
alpha-2,8-sialyltransferase 4 isoform b [Homo sapiens]
Length = 168
Score = 150 bits (378), Expect = 2e-36
Identities = 78/183 (42%), Positives = 116/183 (63%), Gaps = 25/183 (13%)
Query: 6 RSWMLAALTLLVVFLIFADISEIEE----EIGNSGGRGTIRSAVNSLHSKSNRAEVVING 61
+ W + ++LL++F +I+ EE ++ G RS VNS
Sbjct: 6 KRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELSLSRSLVNS-------------- 51
Query: 62 SSSPAVVDRSNESI-KHNIQPASSKWRHNQTLSLRIRKQILKFLDAEKDISVLKGTLKPG 120
S ++ ++ SI +HN++ W+ N +L L IRK IL+FLDAE+D+SV+K + KPG
Sbjct: 52 --SDKIIRKAGSSIFQHNVEG----WKINSSLVLEIRKNILRFLDAERDVSVVKSSFKPG 105
Query: 121 DIIHYIFDRDSTMNVSQNLYELLPRTSPLKNKHFGTCAIVGNSGVLLNSGCGQEIDAHSF 180
D+IHY+ DR T+N+S +L+ LLP SP+KN+ F TCA+VGNSG+LL+S CG+EID+H+F
Sbjct: 106 DVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNF 165
Query: 181 VIR 183
VIR
Sbjct: 166 VIR 168
>gi|54234057 ST8 alpha-N-acetyl-neuraminide
alpha-2,8-sialyltransferase 6 [Homo sapiens]
Length = 398
Score = 149 bits (376), Expect = 4e-36
Identities = 88/295 (29%), Positives = 143/295 (48%), Gaps = 11/295 (3%)
Query: 83 SSKWRHNQTLSLRIRKQILKFLDAEKDISVLKGTLKPGDIIHYIFDRDSTMNVSQNLYEL 142
S W+ R ++ DA ++ V + G + Y + + + +N++ +
Sbjct: 112 SCPWKRQAEEYANFRAKLASCCDAVQNFVVSQNNTPVGTNMSYEVESKKEIPIKKNIFHM 171
Query: 143 LPRTSPLKNKHFGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQ-EYARDVGLKTD 201
P + P + + CA+VGN G+L S CG EID FV RCNL P + ++DVG KT+
Sbjct: 172 FPVSQPFVDYPYNQCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGDVSKDVGSKTN 231
Query: 202 LVTMNPSVIQRAFEDLVNATWREKLLQRLHSLNGSILWIPAFMARGGKERVEWVNELILK 261
LVT+NPS+I + +L + L+ + + + +PAF R V + +
Sbjct: 232 LVTINPSIITLKYGNLKEK--KALFLEDIATYGDAFFLLPAFSFRANTGTSFKVYYTLEE 289
Query: 262 HHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCKQIYLYGFWPFPLD 321
+ + + L + +W T V R +TGL++ ++A CK + LYGFWPF
Sbjct: 290 SKARQKVLFFHPKYLKDLALFWRTKGVTAYRLSTGLMITSVAVELCKNVKLYGFWPFSKT 349
Query: 322 QNQNPVKYHYYDSL--KYGYTSQASPHTMPLEFKALKSLHEQGALKLTVGQCDGA 374
PV +HYYD+ K+G+ H MP E+ + LH +G LKL +C+ A
Sbjct: 350 VEDIPVSHHYYDNKLPKHGF------HQMPKEYSQILQLHMKGILKLQFSKCEVA 398
>gi|21264332 sialyltransferase 7A [Homo sapiens]
Length = 600
Score = 79.3 bits (194), Expect = 5e-15
Identities = 72/247 (29%), Positives = 112/247 (45%), Gaps = 29/247 (11%)
Query: 141 ELLPRTSPLKNKHFGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKT 200
+LL + P + TCA+VGN G+L NS GQEID+H +V R + A ++ Y +DVG +T
Sbjct: 349 QLLLASLPAGSLRCITCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRT 408
Query: 201 DLVTMNPSVIQRAFEDLVNATWRE----KLLQRLHSLNGS--ILWIPAFMARGGKERVEW 254
+ ++ L N ++ K ++ LH L G+ W+ A + + V
Sbjct: 409 SFYGFTAFSLTQSLLILGNRGFKNVPLGKDVRYLHFLEGTRDYEWLEALLM---NQTVMS 465
Query: 255 VNELILKHHVN--VRTAYPSLR--LLHA-----VRGYWLTNKV------HIKRPTTGLLM 299
N +H R A R LLH ++ +L +K I RPTTG L+
Sbjct: 466 KNLFWFRHRPQEAFREALHMDRYLLLHPDFLRYMKNRFLRSKTLDGAHWRIYRPTTGALL 525
Query: 300 YTLATRFCKQIYLYGFWPFPLDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFKALKSLH 359
A + C Q+ YGF + + HYYD+ + H LE + K LH
Sbjct: 526 LLTALQLCDQVSAYGF----ITEGHERFSDHYYDT-SWKRLIFYINHDFKLEREVWKRLH 580
Query: 360 EQGALKL 366
++G ++L
Sbjct: 581 DEGIIRL 587
>gi|109633046 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
isoform 2 [Homo sapiens]
Length = 395
Score = 72.8 bits (177), Expect = 5e-13
Identities = 70/255 (27%), Positives = 106/255 (41%), Gaps = 30/255 (11%)
Query: 137 QNLYELLPR---TSPLKNKHFGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYA 193
Q L ELLP LK K C ++G+ G+L G ++ VIR N APV+ Y+
Sbjct: 149 QTLLELLPEHDLPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYS 208
Query: 194 RDVGLKTDLVTMNP-----SVIQRAFEDLVNATWREKL----LQRLHSLNGSILWIPAFM 244
VG KT + P S ++ DL A + + LQ + W+ F
Sbjct: 209 EHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVDFNWLQAMVKKETLPFWVRLFF 268
Query: 245 ARGGKERV-------EWVNELILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGL 297
+ E++ +N +I+K TA+ L+ +W +K PT G+
Sbjct: 269 WKQVAEKIPLQPKHFRILNPVIIK-----ETAFDILQYSEPQSRFWGRDK---NVPTIGV 320
Query: 298 LMYTLATRFCKQIYLYGFWPFPLDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFKALKS 357
+ LAT C ++ L G F D NQ HY+DS + + H + E K L
Sbjct: 321 IAVVLATHLCDEVSLAG---FGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLK 377
Query: 358 LHEQGALKLTVGQCD 372
L ++G +K G D
Sbjct: 378 LVKEGVVKDLSGGID 392
>gi|109633044 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
isoform 1 [Homo sapiens]
Length = 418
Score = 72.8 bits (177), Expect = 5e-13
Identities = 70/255 (27%), Positives = 106/255 (41%), Gaps = 30/255 (11%)
Query: 137 QNLYELLPR---TSPLKNKHFGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYA 193
Q L ELLP LK K C ++G+ G+L G ++ VIR N APV+ Y+
Sbjct: 172 QTLLELLPEHDLPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYS 231
Query: 194 RDVGLKTDLVTMNP-----SVIQRAFEDLVNATWREKL----LQRLHSLNGSILWIPAFM 244
VG KT + P S ++ DL A + + LQ + W+ F
Sbjct: 232 EHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVDFNWLQAMVKKETLPFWVRLFF 291
Query: 245 ARGGKERV-------EWVNELILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGL 297
+ E++ +N +I+K TA+ L+ +W +K PT G+
Sbjct: 292 WKQVAEKIPLQPKHFRILNPVIIK-----ETAFDILQYSEPQSRFWGRDK---NVPTIGV 343
Query: 298 LMYTLATRFCKQIYLYGFWPFPLDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFKALKS 357
+ LAT C ++ L G F D NQ HY+DS + + H + E K L
Sbjct: 344 IAVVLATHLCDEVSLAG---FGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLK 400
Query: 358 LHEQGALKLTVGQCD 372
L ++G +K G D
Sbjct: 401 LVKEGVVKDLSGGID 415
>gi|5902082 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 [Homo
sapiens]
Length = 350
Score = 72.8 bits (177), Expect = 5e-13
Identities = 58/229 (25%), Positives = 101/229 (44%), Gaps = 49/229 (21%)
Query: 127 FDRDSTMNVSQNLYELLPRTSPLKNK---HFGTCAIVGNSGVLLNSGCGQEIDAHSFVIR 183
F +T V + L++++P +P + + CA+VGNSG L SG GQ++D H+F++R
Sbjct: 119 FKSHNTNEVLEKLFQIVPGENPYRFRDPHQCRRCAVVGNSGNLRGSGYGQDVDGHNFIMR 178
Query: 184 CNLAPVQEYARDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLHSLNGSILWIPAF 243
N AP + +DVG +T M P + ++ K+L +LWI +
Sbjct: 179 MNQAPTVGFEQDVGSRTTHHFMYPESAKNLPANVSFVLVPFKVL--------DLLWIASA 230
Query: 244 MARG---------------GKERVEWVNELILKHHVNVRTAYPSLRLLHAVRGYWLTNKV 288
++ G KE+V+ N K+ + W +
Sbjct: 231 LSTGQIRFTYAPVKSFLRVDKEKVQIYNPAFFKY----------------IHDRWTEH-- 272
Query: 289 HIKRPTTGLLMYTLATRFCKQIYLYGFWPFPLDQNQNPVKYHYYDSLKY 337
H + P+TG+L+ A C ++ +YG F D N +HY+++ +Y
Sbjct: 273 HGRYPSTGMLVLFFALHVCDEVNVYG---FGADSRGN--WHHYWENNRY 316
>gi|13569938 sialyltransferase 7E [Homo sapiens]
Length = 336
Score = 72.0 bits (175), Expect = 8e-13
Identities = 70/204 (34%), Positives = 88/204 (43%), Gaps = 36/204 (17%)
Query: 148 PLKNKHFGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLVTMNP 207
PLK H CA+V +SG LL+S G +ID VIR N AP + Y RDVG +T L +
Sbjct: 88 PLK-MHCRDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVIAH 146
Query: 208 SVIQRAF---EDLVNATWREKLLQRLHSLNGSILWIP-AFMARGGKERVEWVNELILKHH 263
S IQR DL+N + I W P ++M R GK +V N L L
Sbjct: 147 SSIQRILRNRHDLLNVSQGTVF----------IFWGPSSYMRRDGKGQV--YNNLHLLSQ 194
Query: 264 VNVRTAYPSLRLLHAVRGYWLTNKVHIKRPT------------TGLLMYTLATRFCKQIY 311
V P L+ R L K+ T TG T+A C +I
Sbjct: 195 V-----LPRLKAFMITRHKMLQFDELFKQETGKDRKISNTWLSTGWFTMTIALELCDRIN 249
Query: 312 LYGFWP--FPLDQNQNPVKYHYYD 333
+YG P F D N V YHYY+
Sbjct: 250 VYGMVPPDFCRDPNHPSVPYHYYE 273
>gi|5454058 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 [Homo
sapiens]
Length = 329
Score = 64.7 bits (156), Expect = 1e-10
Identities = 64/216 (29%), Positives = 94/216 (43%), Gaps = 14/216 (6%)
Query: 157 CAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFED 216
C +VGN L NS G I+ + VIR N APV Y DVG KT + P + A D
Sbjct: 116 CVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYP---ESAHFD 172
Query: 217 LVNATWREKLLQRLHSLNGSILWIPAFMARGGKERVEWVNELILKHHVN---VRTAYPSL 273
+ LL + WI ++ + R + + L VN +R P
Sbjct: 173 PKVENNPDTLLVLVAFKAMDFHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFF 232
Query: 274 RLLHAVRGYWLTNKVHIK---RPTTGLLMYTLATRFCKQIYLYGF-WPFPLDQNQNPVKY 329
+ A + L + K +PTTGLL TLA C +++ GF +P ++ Q
Sbjct: 233 MEIAADKLLSLPMQQPRKIKQKPTTGLLAITLALHLCDLVHIAGFGYPDAYNKKQT---I 289
Query: 330 HYYDSLKYGYTSQASPHTMPLEFKALKSLHEQGALK 365
HYY+ + + S H + E A+K + E GA+K
Sbjct: 290 HYYEQITL-KSMAGSGHNVSQEALAIKRMLEMGAIK 324
>gi|28373086 sialyltransferase 6 isoform i [Homo sapiens]
Length = 413
Score = 63.9 bits (154), Expect = 2e-10
Identities = 58/242 (23%), Positives = 98/242 (40%), Gaps = 48/242 (19%)
Query: 140 YELLPRTSPLKNKHFGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLK 199
Y L P L+ + C IVGN GVL N G ID + V+R N APV+ + +DVG K
Sbjct: 184 YRLTPALDSLRCRR---CIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSK 240
Query: 200 TDLVTMNPSVIQRAFEDLVNATWREKLLQRLHSLNGSILWIPAFMARGGKERVEWVNELI 259
T L T+ E +QR L++ +A + +W+ ++
Sbjct: 241 TTL----------------RITYPEGAMQRPEQYERDSLFV---LAGFKWQDFKWLKYIV 281
Query: 260 LKHHVNVRTAY------------PSLRLLH---------AVRGYWLTNKVHIKR--PTTG 296
K V+ + P +R+L+ + G N + + PT G
Sbjct: 282 YKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLG 341
Query: 297 LLMYTLATRFCKQIYLYGFWPFPLDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFKALK 356
+ T+A C ++ + G F D + HYY++++ ++ H + E + L+
Sbjct: 342 SVAVTMALHGCDEVAVAG---FGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLR 398
Query: 357 SL 358
L
Sbjct: 399 KL 400
>gi|28373082 sialyltransferase 6 isoform g [Homo sapiens]
Length = 359
Score = 63.9 bits (154), Expect = 2e-10
Identities = 58/242 (23%), Positives = 98/242 (40%), Gaps = 48/242 (19%)
Query: 140 YELLPRTSPLKNKHFGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLK 199
Y L P L+ + C IVGN GVL N G ID + V+R N APV+ + +DVG K
Sbjct: 130 YRLTPALDSLRCRR---CIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSK 186
Query: 200 TDLVTMNPSVIQRAFEDLVNATWREKLLQRLHSLNGSILWIPAFMARGGKERVEWVNELI 259
T L T+ E +QR L++ +A + +W+ ++
Sbjct: 187 TTL----------------RITYPEGAMQRPEQYERDSLFV---LAGFKWQDFKWLKYIV 227
Query: 260 LKHHVNVRTAY------------PSLRLLH---------AVRGYWLTNKVHIKR--PTTG 296
K V+ + P +R+L+ + G N + + PT G
Sbjct: 228 YKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLG 287
Query: 297 LLMYTLATRFCKQIYLYGFWPFPLDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFKALK 356
+ T+A C ++ + G F D + HYY++++ ++ H + E + L+
Sbjct: 288 SVAVTMALHGCDEVAVAG---FGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLR 344
Query: 357 SL 358
L
Sbjct: 345 KL 346
>gi|28373078 sialyltransferase 6 isoform f [Homo sapiens]
Length = 429
Score = 63.9 bits (154), Expect = 2e-10
Identities = 58/242 (23%), Positives = 98/242 (40%), Gaps = 48/242 (19%)
Query: 140 YELLPRTSPLKNKHFGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLK 199
Y L P L+ + C IVGN GVL N G ID + V+R N APV+ + +DVG K
Sbjct: 200 YRLTPALDSLRCRR---CIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSK 256
Query: 200 TDLVTMNPSVIQRAFEDLVNATWREKLLQRLHSLNGSILWIPAFMARGGKERVEWVNELI 259
T L T+ E +QR L++ +A + +W+ ++
Sbjct: 257 TTL----------------RITYPEGAMQRPEQYERDSLFV---LAGFKWQDFKWLKYIV 297
Query: 260 LKHHVNVRTAY------------PSLRLLH---------AVRGYWLTNKVHIKR--PTTG 296
K V+ + P +R+L+ + G N + + PT G
Sbjct: 298 YKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLG 357
Query: 297 LLMYTLATRFCKQIYLYGFWPFPLDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFKALK 356
+ T+A C ++ + G F D + HYY++++ ++ H + E + L+
Sbjct: 358 SVAVTMALHGCDEVAVAG---FGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLR 414
Query: 357 SL 358
L
Sbjct: 415 KL 416
>gi|28373070 sialyltransferase 6 isoform b [Homo sapiens]
Length = 390
Score = 63.9 bits (154), Expect = 2e-10
Identities = 58/242 (23%), Positives = 98/242 (40%), Gaps = 48/242 (19%)
Query: 140 YELLPRTSPLKNKHFGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLK 199
Y L P L+ + C IVGN GVL N G ID + V+R N APV+ + +DVG K
Sbjct: 161 YRLTPALDSLRCRR---CIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSK 217
Query: 200 TDLVTMNPSVIQRAFEDLVNATWREKLLQRLHSLNGSILWIPAFMARGGKERVEWVNELI 259
T L T+ E +QR L++ +A + +W+ ++
Sbjct: 218 TTL----------------RITYPEGAMQRPEQYERDSLFV---LAGFKWQDFKWLKYIV 258
Query: 260 LKHHVNVRTAY------------PSLRLLH---------AVRGYWLTNKVHIKR--PTTG 296
K V+ + P +R+L+ + G N + + PT G
Sbjct: 259 YKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLG 318
Query: 297 LLMYTLATRFCKQIYLYGFWPFPLDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFKALK 356
+ T+A C ++ + G F D + HYY++++ ++ H + E + L+
Sbjct: 319 SVAVTMALHGCDEVAVAG---FGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLR 375
Query: 357 SL 358
L
Sbjct: 376 KL 377
>gi|28373068 sialyltransferase 6 isoform a [Homo sapiens]
Length = 444
Score = 63.9 bits (154), Expect = 2e-10
Identities = 58/242 (23%), Positives = 98/242 (40%), Gaps = 48/242 (19%)
Query: 140 YELLPRTSPLKNKHFGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLK 199
Y L P L+ + C IVGN GVL N G ID + V+R N APV+ + +DVG K
Sbjct: 215 YRLTPALDSLRCRR---CIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSK 271
Query: 200 TDLVTMNPSVIQRAFEDLVNATWREKLLQRLHSLNGSILWIPAFMARGGKERVEWVNELI 259
T L T+ E +QR L++ +A + +W+ ++
Sbjct: 272 TTL----------------RITYPEGAMQRPEQYERDSLFV---LAGFKWQDFKWLKYIV 312
Query: 260 LKHHVNVRTAY------------PSLRLLH---------AVRGYWLTNKVHIKR--PTTG 296
K V+ + P +R+L+ + G N + + PT G
Sbjct: 313 YKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLG 372
Query: 297 LLMYTLATRFCKQIYLYGFWPFPLDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFKALK 356
+ T+A C ++ + G F D + HYY++++ ++ H + E + L+
Sbjct: 373 SVAVTMALHGCDEVAVAG---FGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLR 429
Query: 357 SL 358
L
Sbjct: 430 KL 431
>gi|5454060 sialyltransferase 6 isoform j [Homo sapiens]
Length = 375
Score = 63.9 bits (154), Expect = 2e-10
Identities = 58/242 (23%), Positives = 98/242 (40%), Gaps = 48/242 (19%)
Query: 140 YELLPRTSPLKNKHFGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLK 199
Y L P L+ + C IVGN GVL N G ID + V+R N APV+ + +DVG K
Sbjct: 146 YRLTPALDSLRCRR---CIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSK 202
Query: 200 TDLVTMNPSVIQRAFEDLVNATWREKLLQRLHSLNGSILWIPAFMARGGKERVEWVNELI 259
T L T+ E +QR L++ +A + +W+ ++
Sbjct: 203 TTL----------------RITYPEGAMQRPEQYERDSLFV---LAGFKWQDFKWLKYIV 243
Query: 260 LKHHVNVRTAY------------PSLRLLH---------AVRGYWLTNKVHIKR--PTTG 296
K V+ + P +R+L+ + G N + + PT G
Sbjct: 244 YKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLG 303
Query: 297 LLMYTLATRFCKQIYLYGFWPFPLDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFKALK 356
+ T+A C ++ + G F D + HYY++++ ++ H + E + L+
Sbjct: 304 SVAVTMALHGCDEVAVAG---FGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLR 360
Query: 357 SL 358
L
Sbjct: 361 KL 362
>gi|5174697 alpha2,3-sialyltransferase VI [Homo sapiens]
Length = 331
Score = 63.9 bits (154), Expect = 2e-10
Identities = 56/215 (26%), Positives = 94/215 (43%), Gaps = 20/215 (9%)
Query: 157 CAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFED 216
C +VGN GVL N G++ID++ +IR N PV + +VG +T P + F D
Sbjct: 118 CVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYP---ESVFSD 174
Query: 217 ----------LVNATWREKLLQRLHSLNGSILWIPAFMARGGKERVEWVNELILKHHVNV 266
++ A L L L G + F + + ++ + +
Sbjct: 175 PIHNDPNTTVILTAFKPHDLRWLLELLMGDKINTNGFWKKPALNLIYKPYQIRILDPFII 234
Query: 267 RTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCKQIYLYGFWPFPLDQNQNP 326
RTA + LLH + + K K PTTG++ TLA C +++L GF + ++P
Sbjct: 235 RTA--AYELLHFPKVFPKNQKP--KHPTTGIIAITLAFYICHEVHLAGF-KYNFSDLKSP 289
Query: 327 VKYHYYDSLKYGYTSQASPHTMPLEFKALKSLHEQ 361
+ HYY + ++ + H + E LK + E+
Sbjct: 290 L--HYYGNATMSLMNKNAYHNVTAEQLFLKDIIEK 322
>gi|215272345 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
isoform a [Homo sapiens]
Length = 529
Score = 62.0 bits (149), Expect = 8e-10
Identities = 68/329 (20%), Positives = 133/329 (40%), Gaps = 59/329 (17%)
Query: 42 RSAVNSLHSKSNRAEVVINGSSSPAVVDRSNESIKHNIQPASSKWRHN---QTLSLRIRK 98
R V H + R+ V+ G + + + + + W+ N + L+ R++K
Sbjct: 170 RRRVKKRHRRQRRSHVLEEGDDGDRLYSSMSRAFLYRL------WKGNVSSKMLNPRLQK 223
Query: 99 QILKFLDAEKDISVLKGTLKPG----DIIHYIFDR------DSTMNVSQNL-YELLPRTS 147
+ +L A K +G + G ++ + R D T L + L
Sbjct: 224 AMKDYLTANKHGVRFRGKREAGLSRAQLLCQLRSRARVRTLDGTEAPFSALGWRRLVPAV 283
Query: 148 PLKNKH---FGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLVT 204
PL H +CA+V ++G +LNS G+EID+H V+R N AP + Y +DVG KT +
Sbjct: 284 PLSQLHPRGLRSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRI 343
Query: 205 MNPSVIQRAFEDLVNATWREKLLQRLHSLNGSILWIPAFMARGGKERVEWVNELILKHHV 264
+N ++ ++++ + ++ + W PA + +N K
Sbjct: 344 INSQILTNPSHHFIDSSLYKDVI--------LVAWDPAPYSAN-------LNLWYKKPDY 388
Query: 265 NVRTAYPSLRLLHAVRGYWLTN-----------------KVHIKRPTTGLLMYTLATRFC 307
N+ T Y R + + +++ + K+ P++G + + C
Sbjct: 389 NLFTPYIQHRQRNPNQPFYILHPKFIWQLWDIIQENTKEKIQPNPPSSGFIGILIMMSMC 448
Query: 308 KQIYLYGFWPFPLDQNQNPVKYH--YYDS 334
+++++Y + P + YH YYD+
Sbjct: 449 REVHVYEY--IPSVRQTELCHYHELYYDA 475
>gi|26190610 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
isoform a [Homo sapiens]
Length = 529
Score = 62.0 bits (149), Expect = 8e-10
Identities = 68/329 (20%), Positives = 133/329 (40%), Gaps = 59/329 (17%)
Query: 42 RSAVNSLHSKSNRAEVVINGSSSPAVVDRSNESIKHNIQPASSKWRHN---QTLSLRIRK 98
R V H + R+ V+ G + + + + + W+ N + L+ R++K
Sbjct: 170 RRRVKKRHRRQRRSHVLEEGDDGDRLYSSMSRAFLYRL------WKGNVSSKMLNPRLQK 223
Query: 99 QILKFLDAEKDISVLKGTLKPG----DIIHYIFDR------DSTMNVSQNL-YELLPRTS 147
+ +L A K +G + G ++ + R D T L + L
Sbjct: 224 AMKDYLTANKHGVRFRGKREAGLSRAQLLCQLRSRARVRTLDGTEAPFSALGWRRLVPAV 283
Query: 148 PLKNKH---FGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLVT 204
PL H +CA+V ++G +LNS G+EID+H V+R N AP + Y +DVG KT +
Sbjct: 284 PLSQLHPRGLRSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRI 343
Query: 205 MNPSVIQRAFEDLVNATWREKLLQRLHSLNGSILWIPAFMARGGKERVEWVNELILKHHV 264
+N ++ ++++ + ++ + W PA + +N K
Sbjct: 344 INSQILTNPSHHFIDSSLYKDVI--------LVAWDPAPYSAN-------LNLWYKKPDY 388
Query: 265 NVRTAYPSLRLLHAVRGYWLTN-----------------KVHIKRPTTGLLMYTLATRFC 307
N+ T Y R + + +++ + K+ P++G + + C
Sbjct: 389 NLFTPYIQHRQRNPNQPFYILHPKFIWQLWDIIQENTKEKIQPNPPSSGFIGILIMMSMC 448
Query: 308 KQIYLYGFWPFPLDQNQNPVKYH--YYDS 334
+++++Y + P + YH YYD+
Sbjct: 449 REVHVYEY--IPSVRQTELCHYHELYYDA 475
>gi|27765096 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
[Homo sapiens]
Length = 340
Score = 60.8 bits (146), Expect = 2e-09
Identities = 44/164 (26%), Positives = 73/164 (44%), Gaps = 21/164 (12%)
Query: 157 CAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFED 216
CA+VGNSG L S G EID+H FV+R N AP + DVG KT + P + ++
Sbjct: 142 CAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTTHHLVYPESFRELGDN 201
Query: 217 LVNATWREKLLQRLHSLNGSILWIPAFMARGGKERVEWVNELILKHHVNVRTAYPSLRLL 276
+ +L +++ + W+ + + G ++ + +R + +
Sbjct: 202 V------SMILVPFKTID--LEWVVSAITTGT------ISHTYIPVPAKIRVKQDKILIY 247
Query: 277 HA-----VRGYWLTNKVHIKRPTTGLLMYTLATRFCKQIYLYGF 315
H V WL H + P+TG+L + C ++ LYGF
Sbjct: 248 HPAFIKYVFDNWLQG--HGRYPSTGILSVIFSMHVCDEVDLYGF 289
>gi|4506951 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 [Homo
sapiens]
Length = 340
Score = 60.8 bits (146), Expect = 2e-09
Identities = 44/164 (26%), Positives = 73/164 (44%), Gaps = 21/164 (12%)
Query: 157 CAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFED 216
CA+VGNSG L S G EID+H FV+R N AP + DVG KT + P + ++
Sbjct: 142 CAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTTHHLVYPESFRELGDN 201
Query: 217 LVNATWREKLLQRLHSLNGSILWIPAFMARGGKERVEWVNELILKHHVNVRTAYPSLRLL 276
+ +L +++ + W+ + + G ++ + +R + +
Sbjct: 202 V------SMILVPFKTID--LEWVVSAITTGT------ISHTYIPVPAKIRVKQDKILIY 247
Query: 277 HA-----VRGYWLTNKVHIKRPTTGLLMYTLATRFCKQIYLYGF 315
H V WL H + P+TG+L + C ++ LYGF
Sbjct: 248 HPAFIKYVFDNWLQG--HGRYPSTGILSVIFSMHVCDEVDLYGF 289
>gi|192448440 sialyltransferase 7B [Homo sapiens]
Length = 374
Score = 59.7 bits (143), Expect = 4e-09
Identities = 64/247 (25%), Positives = 96/247 (38%), Gaps = 40/247 (16%)
Query: 144 PRTSPLKNKHFGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLV 203
PR +P K CA+VGN G+L S G IDAH +V R N A ++ + RDVG KT
Sbjct: 141 PRDTPPKCIR---CAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTSFY 197
Query: 204 -----TMNPSVIQRAFEDLVNATWREKL--------LQRLHSLNGSILWIPAFMARGGKE 250
TM S++ + + L ++ L +IL +P +
Sbjct: 198 GFTVNTMKNSLVSYWNLGFTSVPQGQDLQYIFIPSDIRDYVMLRSAILGVPVPEGLDKGD 257
Query: 251 RVEWVNELILKHHVNVRTAYPSLRLLHAVRGYWLTNKV-----------HIKRPTTGLLM 299
R + + +LLH +LT + + P+TG LM
Sbjct: 258 RPH--------AYFGPEASASKFKLLHPDFISYLTERFLKSKLINTHFGDLYMPSTGALM 309
Query: 300 YTLATRFCKQIYLYGFWPFPLDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFKALKSLH 359
A C Q+ YGF + N HY++ A+ H + LE + LH
Sbjct: 310 LLTALHTCDQVSAYGF----ITSNYWKFSDHYFERKMKPLIFYAN-HDLSLEAALWRDLH 364
Query: 360 EQGALKL 366
+ G L+L
Sbjct: 365 KAGILQL 371
>gi|4506949 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
isoform a [Homo sapiens]
Length = 406
Score = 59.7 bits (143), Expect = 4e-09
Identities = 52/224 (23%), Positives = 93/224 (41%), Gaps = 37/224 (16%)
Query: 154 FGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRA 213
+G CA+V ++G L +S G+EID H V+R N AP + +DVG KT + MN ++
Sbjct: 181 WGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLVTTE 240
Query: 214 FEDLVNATWREKLLQRLHSLNGSILWIPAFMARGGKERVEWVNELILKHHVNVRTAYPSL 273
L ++ + E +L I+W P+ + +W N Y +
Sbjct: 241 KRFLKDSLYNEGIL---------IVWDPSVY---HSDIPKWYQ----NPDYNFFNNYKTY 284
Query: 274 RLLHAVRGYWL-----------------TNKVHIKRPTTGLLMYTLATRFCKQIYLYGFW 316
R LH + +++ ++ P++G+L + C Q+ +Y F
Sbjct: 285 RKLHPNQPFYILKPQMPWELWDILQEISPEEIQPNPPSSGMLGIIIMMTLCDQVDIYEFL 344
Query: 317 PFPLDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFKALKSLHE 360
P + + V Y YY + + H + E +K L++
Sbjct: 345 P---SKRKTDVCY-YYQKFFDSACTMGAYHPLLYEKNLVKHLNQ 384
>gi|27765091 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
isoform a [Homo sapiens]
Length = 406
Score = 59.7 bits (143), Expect = 4e-09
Identities = 52/224 (23%), Positives = 93/224 (41%), Gaps = 37/224 (16%)
Query: 154 FGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRA 213
+G CA+V ++G L +S G+EID H V+R N AP + +DVG KT + MN ++
Sbjct: 181 WGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLVTTE 240
Query: 214 FEDLVNATWREKLLQRLHSLNGSILWIPAFMARGGKERVEWVNELILKHHVNVRTAYPSL 273
L ++ + E +L I+W P+ + +W N Y +
Sbjct: 241 KRFLKDSLYNEGIL---------IVWDPSVY---HSDIPKWYQ----NPDYNFFNNYKTY 284
Query: 274 RLLHAVRGYWL-----------------TNKVHIKRPTTGLLMYTLATRFCKQIYLYGFW 316
R LH + +++ ++ P++G+L + C Q+ +Y F
Sbjct: 285 RKLHPNQPFYILKPQMPWELWDILQEISPEEIQPNPPSSGMLGIIIMMTLCDQVDIYEFL 344
Query: 317 PFPLDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFKALKSLHE 360
P + + V Y YY + + H + E +K L++
Sbjct: 345 P---SKRKTDVCY-YYQKFFDSACTMGAYHPLLYEKNLVKHLNQ 384
>gi|215272347 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
isoform b [Homo sapiens]
Length = 466
Score = 58.5 bits (140), Expect = 9e-09
Identities = 48/197 (24%), Positives = 87/197 (44%), Gaps = 23/197 (11%)
Query: 42 RSAVNSLHSKSNRAEVVINGSSSPAVVDRSNESIKHNIQPASSKWRHN---QTLSLRIRK 98
R V H + R+ V+ G + + + + + W+ N + L+ R++K
Sbjct: 170 RRRVKKRHRRQRRSHVLEEGDDGDRLYSSMSRAFLYRL------WKGNVSSKMLNPRLQK 223
Query: 99 QILKFLDAEKDISVLKGTLKPG----DIIHYIFDR------DSTMNVSQNL-YELLPRTS 147
+ +L A K +G + G ++ + R D T L + L
Sbjct: 224 AMKDYLTANKHGVRFRGKREAGLSRAQLLCQLRSRARVRTLDGTEAPFSALGWRRLVPAV 283
Query: 148 PLKNKH---FGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLVT 204
PL H +CA+V ++G +LNS G+EID+H V+R N AP + Y +DVG KT +
Sbjct: 284 PLSQLHPRGLRSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRI 343
Query: 205 MNPSVIQRAFEDLVNAT 221
+N ++ ++++
Sbjct: 344 INSQILTNPSHHFIDSS 360
>gi|28373074 sialyltransferase 6 isoform d [Homo sapiens]
Length = 277
Score = 54.7 bits (130), Expect = 1e-07
Identities = 31/74 (41%), Positives = 40/74 (54%), Gaps = 4/74 (5%)
Query: 140 YELLPRTSPLKNKHFGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLK 199
Y L P L+ + C IVGN GVL N G ID + V+R N APV+ + +DVG K
Sbjct: 146 YRLTPALDSLRCRR---CIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSK 202
Query: 200 TDL-VTMNPSVIQR 212
T L +T +QR
Sbjct: 203 TTLRITYPEGAMQR 216
>gi|28373092 sialyltransferase 7D isoform a [Homo sapiens]
Length = 302
Score = 48.9 bits (115), Expect = 7e-06
Identities = 25/63 (39%), Positives = 35/63 (55%)
Query: 140 YELLPRTSPLKNKHFGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLK 199
Y +P PL + +CA+V +SG +L SG G EID+ V R N AP + DVG +
Sbjct: 59 YSSVPDGKPLVREPCRSCAVVSSSGQMLGSGLGAEIDSAECVFRMNQAPTVGFEADVGQR 118
Query: 200 TDL 202
+ L
Sbjct: 119 STL 121
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,818,394
Number of Sequences: 37866
Number of extensions: 587063
Number of successful extensions: 1270
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 34
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 1198
Number of HSP's gapped (non-prelim): 52
length of query: 375
length of database: 18,247,518
effective HSP length: 104
effective length of query: 271
effective length of database: 14,309,454
effective search space: 3877862034
effective search space used: 3877862034
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.