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Search of human proteins with 5174473
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5174473 intracisternal A particle-promoted polypeptide
isoform 1 [Homo sapiens]
(584 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 1196 0.0
gi|223890235 intracisternal A particle-promoted polypeptide isof... 1127 0.0
gi|40807500 kelch-like 20 [Homo sapiens] 382 e-106
gi|11056006 kelch-like 12 [Homo sapiens] 337 2e-92
gi|38194229 kelch-like 17 [Homo sapiens] 332 8e-91
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 328 6e-90
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 328 6e-90
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 324 1e-88
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 324 1e-88
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 322 6e-88
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 322 6e-88
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 319 4e-87
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 319 4e-87
gi|14780904 kelch-like 1 protein [Homo sapiens] 317 2e-86
gi|166235129 kelch-like 3 [Homo sapiens] 313 3e-85
gi|55925604 kelch-like 18 [Homo sapiens] 311 8e-85
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 304 1e-82
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 303 2e-82
gi|34101268 kelch-like 8 [Homo sapiens] 289 4e-78
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 280 3e-75
gi|148664209 kelch-like 10 [Homo sapiens] 259 5e-69
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 247 2e-65
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens] 241 2e-63
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens] 222 8e-58
gi|24308181 kelch-like 9 [Homo sapiens] 219 4e-57
gi|40018614 DRE1 protein [Homo sapiens] 214 2e-55
gi|55925608 kelch-like 21 [Homo sapiens] 213 4e-55
gi|45643138 kelch-like 13 [Homo sapiens] 212 7e-55
gi|24432026 kelch-like [Homo sapiens] 211 2e-54
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo... 209 7e-54
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 1196 bits (3093), Expect = 0.0
Identities = 584/584 (100%), Positives = 584/584 (100%)
Query: 1 MANEDCPKAADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSP 60
MANEDCPKAADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSP
Sbjct: 1 MANEDCPKAADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSP 60
Query: 61 YFAALFTGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLT 120
YFAALFTGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLT
Sbjct: 61 YFAALFTGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLT 120
Query: 121 EVVHLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTK 180
EVVHLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTK
Sbjct: 121 EVVHLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTK 180
Query: 181 DQLIKILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYI 240
DQLIKILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYI
Sbjct: 181 DQLIKILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYI 240
Query: 241 EGVSDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQ 300
EGVSDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQ
Sbjct: 241 EGVSDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQ 300
Query: 301 GGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCT 360
GGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCT
Sbjct: 301 GGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCT 360
Query: 361 ECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVV 420
ECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVV
Sbjct: 361 ECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVV 420
Query: 421 GNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGV 480
GNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGV
Sbjct: 421 GNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGV 480
Query: 481 AALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG 540
AALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG
Sbjct: 481 AALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG 540
Query: 541 RSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAVL 584
RSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAVL
Sbjct: 541 RSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAVL 584
>gi|223890235 intracisternal A particle-promoted polypeptide isoform
2 [Homo sapiens]
Length = 582
Score = 1127 bits (2914), Expect = 0.0
Identities = 551/552 (99%), Positives = 551/552 (99%)
Query: 1 MANEDCPKAADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSP 60
MANEDCPKAADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSP
Sbjct: 1 MANEDCPKAADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSP 60
Query: 61 YFAALFTGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLT 120
YFAALFTGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLT
Sbjct: 61 YFAALFTGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLT 120
Query: 121 EVVHLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTK 180
EVVHLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTK
Sbjct: 121 EVVHLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTK 180
Query: 181 DQLIKILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYI 240
DQLIKILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYI
Sbjct: 181 DQLIKILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYI 240
Query: 241 EGVSDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQ 300
EGVSDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQ
Sbjct: 241 EGVSDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQ 300
Query: 301 GGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCT 360
GGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCT
Sbjct: 301 GGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCT 360
Query: 361 ECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVV 420
ECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVV
Sbjct: 361 ECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVV 420
Query: 421 GNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGV 480
GNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGV
Sbjct: 421 GNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGV 480
Query: 481 AALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG 540
AALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG
Sbjct: 481 AALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG 540
Query: 541 RSSSHDFLAPGT 552
RSSSHDFLAP T
Sbjct: 541 RSSSHDFLAPDT 552
Score = 100 bits (249), Expect = 4e-21
Identities = 65/201 (32%), Positives = 98/201 (48%), Gaps = 15/201 (7%)
Query: 392 IYALGG--------WVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIG 443
+YA+GG W + + +ERFD W V ++ +R G + G++Y IG
Sbjct: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
Query: 444 GISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTV 503
G + + E YDP++K+W+ + M R LGV IY++GGW + +T+
Sbjct: 350 G-EKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIG-NTI 407
Query: 504 EKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHS 563
E++ +E KW V +M V R + GL+YV GG S+ L S EVY+P S
Sbjct: 408 ERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGI-----ELRSFEVYDPLS 462
Query: 564 DTWTEIGNMITSRCEGGVAVL 584
W+ + M T R GVA L
Sbjct: 463 KRWSPLPPMGTRRAYLGVAAL 483
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 382 bits (982), Expect = e-106
Identities = 221/584 (37%), Positives = 323/584 (55%), Gaps = 22/584 (3%)
Query: 4 EDCPKAADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFA 63
E P+ A P+ SDKH + L IN +R + CDV L VG + AHR++L+A SPYF
Sbjct: 35 EGVPQPARMPYISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFR 94
Query: 64 ALFTGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVV 123
A+FTG + ES + V I I+ ++L+DF YT + + NVQ L+ AA +LQL E+
Sbjct: 95 AMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQ 154
Query: 124 HLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQL 183
CCEFLK Q+DP NC+GI F++ +C +LL ++ + +F EV EEF+ L +QL
Sbjct: 155 EACCEFLKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQL 214
Query: 184 IKILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGV 243
I I+ S+EL++ E QVF A M W+ + +RR + +VL +R PLL P+ L+ +
Sbjct: 215 IDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSD 274
Query: 244 SDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKAR--KYLYAVGGYTRLQG 301
+ L+ E P+E +Q + RPRK R + L+AVGG
Sbjct: 275 PLIKSDEECRDLVDEAKNYLLLPQER---PLMQGPRTRPRKPIRCGEVLFAVGG------ 325
Query: 302 GRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTE 361
W A+S VER+D + W V+S+ + R G+GV+VL ++YA+GG S + E
Sbjct: 326 --WCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVE 383
Query: 362 CYDPVTKQWTT-VASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVV 420
YDP T QW++ VA + R +GV V G +YA+GG G N +ER+DP ENKW V
Sbjct: 384 RYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRV 443
Query: 421 GNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGV 480
+M+ R + G +Y +GG S+ L + E Y+P RW + PMGTRR +LG
Sbjct: 444 ASMSTRRLGVAVAVLGGFLYAVGG-SDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGC 502
Query: 481 AALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG 540
A D IY+VGG ++T + L + E+Y+ +W V +M R+G+ + VNG L GG
Sbjct: 503 AVYQDMIYAVGGRDDTTE-LSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGG 561
Query: 541 RSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAVL 584
F L ++EV++P ++TW G M R GGV V+
Sbjct: 562 ------FDGTTYLKTIEVFDPDANTWRLYGGMNYRRLGGGVGVI 599
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 337 bits (863), Expect = 2e-92
Identities = 201/578 (34%), Positives = 302/578 (52%), Gaps = 21/578 (3%)
Query: 10 ADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGG 69
A ++ HA+ IL +N +R CDV L+V Q+ F AHR+VLAA S YF A+FT
Sbjct: 6 APKDIMTNTHAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSE 65
Query: 70 MKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEF 129
+ E K V I G+ A +ILLDF+YT V++ V NVQEL+ AA +LQL V CCEF
Sbjct: 66 LSEKGKPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEF 125
Query: 130 LKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRS 189
L+ Q+DP NC+GI F+E C DL++ +E + HF EV EEF+ L++ ++ K+++
Sbjct: 126 LESQLDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKC 185
Query: 190 EELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLR 249
+E+ ++ E VF A + W+ +R + + +L +R PLL P+ + I+
Sbjct: 186 DEIQVDSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCS 245
Query: 250 VALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRA 309
+ + L+ E + P + S +Q + R R A + L VGG+ S
Sbjct: 246 LQCRDLVDEAKKFHLRP---ELRSQMQGPRTRARLGANEVLLVVGGF-------GSQQSP 295
Query: 310 LSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQ 369
+ VE++D +Q W+ + S+ + R + L +Y IGG EC D +
Sbjct: 296 IDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADE 355
Query: 370 ---WTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVS 426
W +VA MN R G IY GG+ G+ ++ER+DP+ ++W ++G+M +
Sbjct: 356 DGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTA 415
Query: 427 RYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDC 486
R G G+IY +GG I L S E YDP + W+ + PM T+R+ GVA LND
Sbjct: 416 REGAGLVVASGVIYCLGGYDGLNI-LNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDH 474
Query: 487 IYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHD 546
IY VGG++ T L +VE Y+ + W V SM PR + + G LY G +
Sbjct: 475 IYVVGGFDGTAH-LSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGN-- 531
Query: 547 FLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAVL 584
L S+E Y+P D+W + +M T RC+ GV VL
Sbjct: 532 ----SLLSSIECYDPIIDSWEVVTSMGTQRCDAGVCVL 565
Score = 114 bits (284), Expect = 3e-25
Identities = 60/184 (32%), Positives = 90/184 (48%), Gaps = 1/184 (0%)
Query: 302 GRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTE 361
G + SR + +ER+D W+ + + AR G G+ V G++Y +GG I + E
Sbjct: 385 GGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLNILNSVE 444
Query: 362 CYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVG 421
YDP T WT V M R G GV + IY +GG+ G +++E ++ + W V
Sbjct: 445 KYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVT 504
Query: 422 NMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVA 481
+M R Y G ++G +Y I G + L S E YDP+ W + MGT+R GV
Sbjct: 505 SMTTPRCYVGATVLRGRLYAIAGYDGNSL-LSSIECYDPIIDSWEVVTSMGTQRCDAGVC 563
Query: 482 ALND 485
L +
Sbjct: 564 VLRE 567
Score = 100 bits (248), Expect = 5e-21
Identities = 52/147 (35%), Positives = 78/147 (53%), Gaps = 8/147 (5%)
Query: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
+Y +GGY L L+ VE++D + +WT V+ + RSG GV +L +Y +G
Sbjct: 428 IYCLGGYDGLN--------ILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVG 479
Query: 350 GEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIER 409
G + E Y+ T WTTV SM PRC +G V G +YA+ G+ G + ++IE
Sbjct: 480 GFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIEC 539
Query: 410 FDPDENKWEVVGNMAVSRYYFGCCEMQ 436
+DP + WEVV +M R G C ++
Sbjct: 540 YDPIIDSWEVVTSMGTQRCDAGVCVLR 566
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 332 bits (850), Expect = 8e-91
Identities = 198/574 (34%), Positives = 301/574 (52%), Gaps = 25/574 (4%)
Query: 15 SSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESS 74
+S +H +++MR CD+ L V + +AH++VLA+ SPYF A+FT M ES
Sbjct: 70 NSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESR 129
Query: 75 KDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQI 134
+ V + I+ L+ F YT + +G NVQ L+ AA +LQL V CC+FL Q+
Sbjct: 130 QTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQL 189
Query: 135 DPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSI 194
DP NC+GI F++ +C DLL+ + Y+ HF++V EEF+ L Q+++++ S+ L++
Sbjct: 190 DPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNV 249
Query: 195 EDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQT 254
E +V+ A + W+ D+ RR+HV ++ +R PLL LL +++ S +
Sbjct: 250 PSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKD 309
Query: 255 LLKEYCEVCKSPKENKFCSFLQTSKVRPRK--KARKYLYAVGGYT--RLQGGRWSDSRAL 310
LL E + P++ L TS+ RPR+ A L+AVGG + + G
Sbjct: 310 LLIEALKFHLLPEQR---GVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGD-------- 358
Query: 311 SCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQW 370
E +DT + W V+S+ R+ +GV +G +YA+GG + E YDPVT W
Sbjct: 359 --CEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTW 416
Query: 371 TTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYF 430
SM R LGV +G +Y+ GG+ GA N+ ER+DP W V M+ R Y
Sbjct: 417 QPEVSMGTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYV 476
Query: 431 GCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSV 490
+ G +Y +GG + L + E Y+P WSP+ M +RR+ GVA L +Y
Sbjct: 477 RVATLDGNLYAVGGYDSSS-HLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVA 535
Query: 491 GGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAP 550
GG N+ L++VE+YS + W VA M + R+ +VA++G LY GG S
Sbjct: 536 GG-NDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGS------ 588
Query: 551 GTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAVL 584
+L+S+E YNP ++ W M T R GVAVL
Sbjct: 589 SSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVL 622
Score = 81.6 bits (200), Expect = 2e-15
Identities = 49/147 (33%), Positives = 70/147 (47%), Gaps = 8/147 (5%)
Query: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
LYAVGGY S L+ VE+++ W+ V+S+ RS GV VL G +Y G
Sbjct: 485 LYAVGGY--------DSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAG 536
Query: 350 GEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIER 409
G + + E Y P W +VA MN R + G +YA+GG G+ N+IE+
Sbjct: 537 GNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEK 596
Query: 410 FDPDENKWEVVGNMAVSRYYFGCCEMQ 436
++P NKW M R G ++
Sbjct: 597 YNPRTNKWVAASCMFTRRSSVGVAVLE 623
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 328 bits (842), Expect = 6e-90
Identities = 200/590 (33%), Positives = 310/590 (52%), Gaps = 55/590 (9%)
Query: 14 FSSDKHAQLILAQINKMRNGQHFCDVQLQVGQES-----FKAHRLVLAASSPYFAALFTG 68
++ + H + +N++R Q CDV LQV + F AH++VLA+SSP F A+FT
Sbjct: 54 YTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTN 113
Query: 69 GMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCE 128
G++E +VV I GI + + L++F YT +++G V ++ A M Q+ VV C +
Sbjct: 114 GLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSD 173
Query: 129 FLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILR 188
FL Q+DP N IGI F+EQI C +L + + YI++HF EV EEF L+ QL+ ++
Sbjct: 174 FLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLIS 233
Query: 189 SEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQ---------RLLKY 239
++L++ E +VF A + W+ D +RR +V +L +R L P +L+
Sbjct: 234 RDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQS 293
Query: 240 IEGVSDFNLRVALQTLLKEYCEV--CKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYT 297
D+ +++ + L + +V C++PK + +Y GGY
Sbjct: 294 DSRCKDYLVKIFEELTLHKPTQVMPCRAPKVGRL------------------IYTAGGYF 335
Query: 298 RLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDS--- 354
R ++LS +E ++ W ++ L RSGL V+GG++YA+GG +S
Sbjct: 336 R---------QSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
Query: 355 -MIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPD 413
+CY+P+T QW+ A M+ PR +GV V G IYA+GG G N++ER++P+
Sbjct: 387 NTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPE 446
Query: 414 ENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGT 473
++W +V M R G + L+Y +GG L S E Y P W + M T
Sbjct: 447 RDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTN-RLNSAECYYPERNEWRMITAMNT 505
Query: 474 RRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNG 533
R+ GV L++CIY+ GG+ + QD L++VE+Y E E W VA MK R+ + + G
Sbjct: 506 IRSGAGVCVLHNCIYAAGGY-DGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQG 564
Query: 534 LLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAV 583
+YV GG H F LDSVE Y+P +DTW+E+ M + R GVAV
Sbjct: 565 RIYVLGG-YDGHTF-----LDSVECYDPDTDTWSEVTRMTSGRSGVGVAV 608
Score = 102 bits (255), Expect = 7e-22
Identities = 64/198 (32%), Positives = 99/198 (50%), Gaps = 15/198 (7%)
Query: 392 IYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNE--- 448
IY GG+ + + +E ++P + W + ++ V R C + GL+Y +GG +N
Sbjct: 328 IYTAGGYFRQSL-SYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
Query: 449 GIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALH--TVEKY 506
+ + + Y+P++ +WSP PM R +GV ++ IY+VGG + +H +VE+Y
Sbjct: 387 NTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGG---SHGCIHHNSVERY 443
Query: 507 SFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTW 566
E ++W VA M R G+ V +N LLY GG F L+S E Y P + W
Sbjct: 444 EPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGG------FDGTNRLNSAECYYPERNEW 497
Query: 567 TEIGNMITSRCEGGVAVL 584
I M T R GV VL
Sbjct: 498 RMITAMNTIRSGAGVCVL 515
Score = 65.1 bits (157), Expect = 2e-10
Identities = 47/150 (31%), Positives = 68/150 (45%), Gaps = 11/150 (7%)
Query: 438 LIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQ 497
LIY GG + + E Y+P W L + R+ L + +Y+VGG N +
Sbjct: 327 LIYTAGGYFRQSLSY--LEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSP 384
Query: 498 DA---LHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLD 554
D ++ Y+ +W A M VPR + V ++G +Y GG SH + +
Sbjct: 385 DGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGG---SHGCIHH---N 438
Query: 555 SVEVYNPHSDTWTEIGNMITSRCEGGVAVL 584
SVE Y P D W + M+T R GVAVL
Sbjct: 439 SVERYEPERDEWHLVAPMLTRRIGVGVAVL 468
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 328 bits (842), Expect = 6e-90
Identities = 200/590 (33%), Positives = 310/590 (52%), Gaps = 55/590 (9%)
Query: 14 FSSDKHAQLILAQINKMRNGQHFCDVQLQVGQES-----FKAHRLVLAASSPYFAALFTG 68
++ + H + +N++R Q CDV LQV + F AH++VLA+SSP F A+FT
Sbjct: 54 YTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTN 113
Query: 69 GMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCE 128
G++E +VV I GI + + L++F YT +++G V ++ A M Q+ VV C +
Sbjct: 114 GLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSD 173
Query: 129 FLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILR 188
FL Q+DP N IGI F+EQI C +L + + YI++HF EV EEF L+ QL+ ++
Sbjct: 174 FLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLIS 233
Query: 189 SEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQ---------RLLKY 239
++L++ E +VF A + W+ D +RR +V +L +R L P +L+
Sbjct: 234 RDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQS 293
Query: 240 IEGVSDFNLRVALQTLLKEYCEV--CKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYT 297
D+ +++ + L + +V C++PK + +Y GGY
Sbjct: 294 DSRCKDYLVKIFEELTLHKPTQVMPCRAPKVGRL------------------IYTAGGYF 335
Query: 298 RLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDS--- 354
R ++LS +E ++ W ++ L RSGL V+GG++YA+GG +S
Sbjct: 336 R---------QSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
Query: 355 -MIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPD 413
+CY+P+T QW+ A M+ PR +GV V G IYA+GG G N++ER++P+
Sbjct: 387 NTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPE 446
Query: 414 ENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGT 473
++W +V M R G + L+Y +GG L S E Y P W + M T
Sbjct: 447 RDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTN-RLNSAECYYPERNEWRMITAMNT 505
Query: 474 RRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNG 533
R+ GV L++CIY+ GG+ + QD L++VE+Y E E W VA MK R+ + + G
Sbjct: 506 IRSGAGVCVLHNCIYAAGGY-DGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQG 564
Query: 534 LLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAV 583
+YV GG H F LDSVE Y+P +DTW+E+ M + R GVAV
Sbjct: 565 RIYVLGG-YDGHTF-----LDSVECYDPDTDTWSEVTRMTSGRSGVGVAV 608
Score = 102 bits (255), Expect = 7e-22
Identities = 64/198 (32%), Positives = 99/198 (50%), Gaps = 15/198 (7%)
Query: 392 IYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNE--- 448
IY GG+ + + +E ++P + W + ++ V R C + GL+Y +GG +N
Sbjct: 328 IYTAGGYFRQSL-SYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
Query: 449 GIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALH--TVEKY 506
+ + + Y+P++ +WSP PM R +GV ++ IY+VGG + +H +VE+Y
Sbjct: 387 NTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGG---SHGCIHHNSVERY 443
Query: 507 SFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTW 566
E ++W VA M R G+ V +N LLY GG F L+S E Y P + W
Sbjct: 444 EPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGG------FDGTNRLNSAECYYPERNEW 497
Query: 567 TEIGNMITSRCEGGVAVL 584
I M T R GV VL
Sbjct: 498 RMITAMNTIRSGAGVCVL 515
Score = 65.1 bits (157), Expect = 2e-10
Identities = 47/150 (31%), Positives = 68/150 (45%), Gaps = 11/150 (7%)
Query: 438 LIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQ 497
LIY GG + + E Y+P W L + R+ L + +Y+VGG N +
Sbjct: 327 LIYTAGGYFRQSLSY--LEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSP 384
Query: 498 DA---LHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLD 554
D ++ Y+ +W A M VPR + V ++G +Y GG SH + +
Sbjct: 385 DGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGG---SHGCIHH---N 438
Query: 555 SVEVYNPHSDTWTEIGNMITSRCEGGVAVL 584
SVE Y P D W + M+T R GVAVL
Sbjct: 439 SVERYEPERDEWHLVAPMLTRRIGVGVAVL 468
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 324 bits (831), Expect = 1e-88
Identities = 186/575 (32%), Positives = 298/575 (51%), Gaps = 24/575 (4%)
Query: 7 PKAADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALF 66
P +D F + HA+ ++ + CDV L G AHRLVL++ S YFAA+F
Sbjct: 144 PCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMF 203
Query: 67 TGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLC 126
T ++E+ ++ + + G+E L+ + YTG + + +N++ L+ A +LQL++VV C
Sbjct: 204 TNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEAC 263
Query: 127 CEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKI 186
C+FL Q+ P NC+GI F++ C DL + + NY HF+EV +EF+ L ++ K+
Sbjct: 264 CKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKL 323
Query: 187 LRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDF 246
L S++++I +E + A + W+ DL +RRK + ++L IR PLL PQ L +E F
Sbjct: 324 LASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQ-FLADMENNVLF 382
Query: 247 NLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSD 306
+ Q L+ E + P+ LQ+ + +PRK L+AVGG +G
Sbjct: 383 RDDIECQKLIMEAMKYHLLPERR---PMLQSPRTKPRKSTVGTLFAVGGMDSTKGA---- 435
Query: 307 SRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPV 366
+ +E++D + WT V++++ R GV VL +Y +GG + ECY+P
Sbjct: 436 ----TSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPK 491
Query: 367 TKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVS 426
TK W+ + M+ R GLGV V G +YA+GG G NT+ER+DP +W V M+
Sbjct: 492 TKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTP 551
Query: 427 RYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDC 486
R G + G +Y +GG L+S E +DP + +W+ M RR +GV N
Sbjct: 552 RSTVGVAVLSGKLYAVGGRDGSSC-LKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGL 610
Query: 487 IYSVGGW-----NETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGR 541
+Y++GG N T VE+Y + + W VASM + R + V + LY GG
Sbjct: 611 LYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGG- 669
Query: 542 SSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSR 576
+ L++VE Y+P ++ WT++ + R
Sbjct: 670 -----YDGQAYLNTVEAYDPQTNEWTQVAPLCLGR 699
Score = 73.9 bits (180), Expect = 4e-13
Identities = 44/123 (35%), Positives = 60/123 (48%), Gaps = 5/123 (4%)
Query: 263 CKSPKENKFCSFLQTSKVRPRKKARKY---LYAVGGYTRLQGGRWSDSRALSCVERFDTF 319
C P NK+ Q SK R + LYA+GG+ SR CVER+D
Sbjct: 581 CFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNL--TSRLSDCVERYDPK 638
Query: 320 SQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHP 379
+ WT V+S+ +R +GV +LG +YA+GG + E YDP T +WT VA +
Sbjct: 639 TDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLG 698
Query: 380 RCG 382
R G
Sbjct: 699 RAG 701
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 324 bits (831), Expect = 1e-88
Identities = 186/575 (32%), Positives = 298/575 (51%), Gaps = 24/575 (4%)
Query: 7 PKAADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALF 66
P +D F + HA+ ++ + CDV L G AHRLVL++ S YFAA+F
Sbjct: 190 PCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMF 249
Query: 67 TGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLC 126
T ++E+ ++ + + G+E L+ + YTG + + +N++ L+ A +LQL++VV C
Sbjct: 250 TNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEAC 309
Query: 127 CEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKI 186
C+FL Q+ P NC+GI F++ C DL + + NY HF+EV +EF+ L ++ K+
Sbjct: 310 CKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKL 369
Query: 187 LRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDF 246
L S++++I +E + A + W+ DL +RRK + ++L IR PLL PQ L +E F
Sbjct: 370 LASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQ-FLADMENNVLF 428
Query: 247 NLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSD 306
+ Q L+ E + P+ LQ+ + +PRK L+AVGG +G
Sbjct: 429 RDDIECQKLIMEAMKYHLLPERR---PMLQSPRTKPRKSTVGTLFAVGGMDSTKGA---- 481
Query: 307 SRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPV 366
+ +E++D + WT V++++ R GV VL +Y +GG + ECY+P
Sbjct: 482 ----TSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPK 537
Query: 367 TKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVS 426
TK W+ + M+ R GLGV V G +YA+GG G NT+ER+DP +W V M+
Sbjct: 538 TKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTP 597
Query: 427 RYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDC 486
R G + G +Y +GG L+S E +DP + +W+ M RR +GV N
Sbjct: 598 RSTVGVAVLSGKLYAVGGRDGSSC-LKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGL 656
Query: 487 IYSVGGW-----NETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGR 541
+Y++GG N T VE+Y + + W VASM + R + V + LY GG
Sbjct: 657 LYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGG- 715
Query: 542 SSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSR 576
+ L++VE Y+P ++ WT++ + R
Sbjct: 716 -----YDGQAYLNTVEAYDPQTNEWTQVAPLCLGR 745
Score = 73.9 bits (180), Expect = 4e-13
Identities = 44/123 (35%), Positives = 60/123 (48%), Gaps = 5/123 (4%)
Query: 263 CKSPKENKFCSFLQTSKVRPRKKARKY---LYAVGGYTRLQGGRWSDSRALSCVERFDTF 319
C P NK+ Q SK R + LYA+GG+ SR CVER+D
Sbjct: 627 CFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNL--TSRLSDCVERYDPK 684
Query: 320 SQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHP 379
+ WT V+S+ +R +GV +LG +YA+GG + E YDP T +WT VA +
Sbjct: 685 TDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLG 744
Query: 380 RCG 382
R G
Sbjct: 745 RAG 747
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 322 bits (825), Expect = 6e-88
Identities = 189/564 (33%), Positives = 293/564 (51%), Gaps = 24/564 (4%)
Query: 10 ADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGG 69
++ F HA+ L ++ + CDV L G AHRLVL+A S YFAA+FT
Sbjct: 155 SEEQFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTND 214
Query: 70 MKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEF 129
+ E+ ++ V + G++ L+ + YTG++ + + ++ L+ AA +LQLT+V+ +C F
Sbjct: 215 VLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNF 274
Query: 130 LKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRS 189
L Q+ P NC+GI F + C +LL + Y HF+EV +EFL L +++ K+L S
Sbjct: 275 LIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCS 334
Query: 190 EELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLR 249
+++++ DE +F A MQW+ D+ R+ + +L IR PLLPPQ LL +E S F
Sbjct: 335 DDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LLADLETSSMFTGD 393
Query: 250 VALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRA 309
+ Q LL E + P+ S +Q+ + +PRK LYAVGG ++G
Sbjct: 394 LECQKLLMEAMKYHLLPERR---SMMQSPRTKPRKSTVGALYAVGGMDAMKG-------- 442
Query: 310 LSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQ 369
+ +E++D + W + +++ R GV V+ +Y +GG + EC++PV K
Sbjct: 443 TTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKI 502
Query: 370 WTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYY 429
WT + M+ R GLGV G +YA+GG G NT+ER+DP+ +W V +M+ R
Sbjct: 503 WTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRST 562
Query: 430 FGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYS 489
G + +Y IGG L+S E +DP + +WS PM RR +GVA N +Y
Sbjct: 563 VGVVALNNKLYAIGGRDGSSC-LKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYV 621
Query: 490 VGGW-----NETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSS 544
VGG N VE+Y + + W VA + VPR + V + LYV GG
Sbjct: 622 VGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGG-YDG 680
Query: 545 HDFLAPGTLDSVEVYNPHSDTWTE 568
H + L++VE Y+ + W E
Sbjct: 681 HTY-----LNTVESYDAQRNEWKE 699
Score = 124 bits (312), Expect = 2e-28
Identities = 75/195 (38%), Positives = 111/195 (56%), Gaps = 12/195 (6%)
Query: 390 GAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEG 449
GA+YA+GG + TIE++D N W +G M R FG + +YV+GG +G
Sbjct: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGG--RDG 486
Query: 450 IE-LRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSF 508
++ L + E ++P+ K W+ +PPM T R LGVA L +Y+VGG ++ L+TVE++
Sbjct: 487 LKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGG-HDGWSYLNTVERWDP 545
Query: 509 EEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTE 568
E +W VASM PR+ + VVA+N LY GGR S L S+E ++PH++ W+
Sbjct: 546 EGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGS------SCLKSMEYFDPHTNKWSL 599
Query: 569 IGNMITSRCEGGVAV 583
M S+ GGV V
Sbjct: 600 CAPM--SKRRGGVGV 612
Score = 84.3 bits (207), Expect = 3e-16
Identities = 45/146 (30%), Positives = 69/146 (47%), Gaps = 14/146 (9%)
Query: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
LYA+GG S L +E FD + W+ + + + R G+GV G +Y +G
Sbjct: 572 LYAIGGR--------DGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVG 623
Query: 350 GEKD------SMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEI 403
G S + DC E YDP W+TVA ++ PR + VC +Y +GG+ G
Sbjct: 624 GHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTY 683
Query: 404 GNTIERFDPDENKWEVVGNMAVSRYY 429
NT+E +D N+W+ + +Y
Sbjct: 684 LNTVESYDAQRNEWKESMQELLQNFY 709
Score = 53.9 bits (128), Expect = 4e-07
Identities = 33/98 (33%), Positives = 47/98 (47%), Gaps = 7/98 (7%)
Query: 487 IYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHD 546
+Y+VGG + + T+EKY W+ + +M R V ++ LYV GGR
Sbjct: 431 LYAVGGMDAMKGTT-TIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLK- 488
Query: 547 FLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAVL 584
TL++VE +NP WT + M T R GVA L
Sbjct: 489 -----TLNTVECFNPVGKIWTVMPPMSTHRHGLGVATL 521
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 322 bits (825), Expect = 6e-88
Identities = 189/564 (33%), Positives = 293/564 (51%), Gaps = 24/564 (4%)
Query: 10 ADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGG 69
++ F HA+ L ++ + CDV L G AHRLVL+A S YFAA+FT
Sbjct: 155 SEEQFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTND 214
Query: 70 MKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEF 129
+ E+ ++ V + G++ L+ + YTG++ + + ++ L+ AA +LQLT+V+ +C F
Sbjct: 215 VLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNF 274
Query: 130 LKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRS 189
L Q+ P NC+GI F + C +LL + Y HF+EV +EFL L +++ K+L S
Sbjct: 275 LIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCS 334
Query: 190 EELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLR 249
+++++ DE +F A MQW+ D+ R+ + +L IR PLLPPQ LL +E S F
Sbjct: 335 DDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LLADLETSSMFTGD 393
Query: 250 VALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRA 309
+ Q LL E + P+ S +Q+ + +PRK LYAVGG ++G
Sbjct: 394 LECQKLLMEAMKYHLLPERR---SMMQSPRTKPRKSTVGALYAVGGMDAMKG-------- 442
Query: 310 LSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQ 369
+ +E++D + W + +++ R GV V+ +Y +GG + EC++PV K
Sbjct: 443 TTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKI 502
Query: 370 WTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYY 429
WT + M+ R GLGV G +YA+GG G NT+ER+DP+ +W V +M+ R
Sbjct: 503 WTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRST 562
Query: 430 FGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYS 489
G + +Y IGG L+S E +DP + +WS PM RR +GVA N +Y
Sbjct: 563 VGVVALNNKLYAIGGRDGSSC-LKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYV 621
Query: 490 VGGW-----NETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSS 544
VGG N VE+Y + + W VA + VPR + V + LYV GG
Sbjct: 622 VGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGG-YDG 680
Query: 545 HDFLAPGTLDSVEVYNPHSDTWTE 568
H + L++VE Y+ + W E
Sbjct: 681 HTY-----LNTVESYDAQRNEWKE 699
Score = 124 bits (312), Expect = 2e-28
Identities = 75/195 (38%), Positives = 111/195 (56%), Gaps = 12/195 (6%)
Query: 390 GAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEG 449
GA+YA+GG + TIE++D N W +G M R FG + +YV+GG +G
Sbjct: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGG--RDG 486
Query: 450 IE-LRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSF 508
++ L + E ++P+ K W+ +PPM T R LGVA L +Y+VGG ++ L+TVE++
Sbjct: 487 LKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGG-HDGWSYLNTVERWDP 545
Query: 509 EEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTE 568
E +W VASM PR+ + VVA+N LY GGR S L S+E ++PH++ W+
Sbjct: 546 EGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGS------SCLKSMEYFDPHTNKWSL 599
Query: 569 IGNMITSRCEGGVAV 583
M S+ GGV V
Sbjct: 600 CAPM--SKRRGGVGV 612
Score = 55.5 bits (132), Expect = 1e-07
Identities = 32/99 (32%), Positives = 43/99 (43%), Gaps = 2/99 (2%)
Query: 289 YLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAI 348
+LY VGG+ S R CVER+D W+TV+ L R + V LG +Y +
Sbjct: 618 FLYVVGGHDAPASNHCS--RLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVV 675
Query: 349 GGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCV 387
GG + E YD +W +N R G V V
Sbjct: 676 GGYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVV 714
Score = 53.9 bits (128), Expect = 4e-07
Identities = 33/98 (33%), Positives = 47/98 (47%), Gaps = 7/98 (7%)
Query: 487 IYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHD 546
+Y+VGG + + T+EKY W+ + +M R V ++ LYV GGR
Sbjct: 431 LYAVGGMDAMKGTT-TIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLK- 488
Query: 547 FLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAVL 584
TL++VE +NP WT + M T R GVA L
Sbjct: 489 -----TLNTVECFNPVGKIWTVMPPMSTHRHGLGVATL 521
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 319 bits (818), Expect = 4e-87
Identities = 193/568 (33%), Positives = 297/568 (52%), Gaps = 18/568 (3%)
Query: 19 HAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVV 78
H + +N++R+ CDV + AHR+VLAA SPYF A+FTG M ES V
Sbjct: 42 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 101
Query: 79 PILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLN 138
I ++ ++L+D++YT + + NVQ L+ AA +LQL +V CCEFL+ Q+ P+N
Sbjct: 102 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 161
Query: 139 CIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEY 198
C+GI F++ AC DLL + Y HF +V EEFL L +Q+ ++ S++L+I E
Sbjct: 162 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 221
Query: 199 QVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKE 258
+VF A + W+ D R++ + +++ +R PLLP + L++ +E + A + L E
Sbjct: 222 KVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIE 281
Query: 259 YCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDT 318
+ P E + +++R K + VGG +A+ VE +D
Sbjct: 282 AMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQA---------PKAIRSVECYDF 332
Query: 319 FSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNH 378
+ W V+ L R G+ + G+V+A+GG S+ + YDPV QWT+VA+M
Sbjct: 333 KEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRD 392
Query: 379 PRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGL 438
R LG V G +YA+GG+ G+ +++E ++ N+W V M R G + GL
Sbjct: 393 RRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGL 452
Query: 439 IYVIGGISNEGIE-LRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQ 497
+Y +GG + L + E Y+ + W+ + M TRR+ GV LN+ +Y+VGG ++
Sbjct: 453 LYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG-HDGP 511
Query: 498 DALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVE 557
+VE Y W +VA M + R V AVNGLLYV GG S + L SVE
Sbjct: 512 LVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCN------LASVE 565
Query: 558 VYNPHSDTWTEIGN-MITSRCEGGVAVL 584
YNP +D WT + + M T R GV V+
Sbjct: 566 YYNPTTDKWTVVSSCMSTGRSYAGVTVI 593
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 319 bits (818), Expect = 4e-87
Identities = 193/568 (33%), Positives = 297/568 (52%), Gaps = 18/568 (3%)
Query: 19 HAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVV 78
H + +N++R+ CDV + AHR+VLAA SPYF A+FTG M ES V
Sbjct: 38 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 97
Query: 79 PILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLN 138
I ++ ++L+D++YT + + NVQ L+ AA +LQL +V CCEFL+ Q+ P+N
Sbjct: 98 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 157
Query: 139 CIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEY 198
C+GI F++ AC DLL + Y HF +V EEFL L +Q+ ++ S++L+I E
Sbjct: 158 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 217
Query: 199 QVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKE 258
+VF A + W+ D R++ + +++ +R PLLP + L++ +E + A + L E
Sbjct: 218 KVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIE 277
Query: 259 YCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDT 318
+ P E + +++R K + VGG +A+ VE +D
Sbjct: 278 AMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQA---------PKAIRSVECYDF 328
Query: 319 FSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNH 378
+ W V+ L R G+ + G+V+A+GG S+ + YDPV QWT+VA+M
Sbjct: 329 KEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRD 388
Query: 379 PRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGL 438
R LG V G +YA+GG+ G+ +++E ++ N+W V M R G + GL
Sbjct: 389 RRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGL 448
Query: 439 IYVIGGISNEGIE-LRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQ 497
+Y +GG + L + E Y+ + W+ + M TRR+ GV LN+ +Y+VGG ++
Sbjct: 449 LYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG-HDGP 507
Query: 498 DALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVE 557
+VE Y W +VA M + R V AVNGLLYV GG S + L SVE
Sbjct: 508 LVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCN------LASVE 561
Query: 558 VYNPHSDTWTEIGN-MITSRCEGGVAVL 584
YNP +D WT + + M T R GV V+
Sbjct: 562 YYNPTTDKWTVVSSCMSTGRSYAGVTVI 589
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 317 bits (812), Expect = 2e-86
Identities = 184/571 (32%), Positives = 298/571 (52%), Gaps = 24/571 (4%)
Query: 19 HAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVV 78
HA+ ++ Q CDV L VG AHRLVL++ S YFAA+FT + E+ ++ +
Sbjct: 194 HAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEI 253
Query: 79 PILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLN 138
+ GI+ L+ F YTG + + + ++ L+ AA +LQL +VV +CC FL + P N
Sbjct: 254 KMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSN 313
Query: 139 CIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEY 198
C+GI F++ C +L++ + +Y + +EV +EFL L ++L K+L S+++++ DE
Sbjct: 314 CLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEE 373
Query: 199 QVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKE 258
+F A M W+ D+ R + +L IR PLLPPQ +L +E + F + Q L+ E
Sbjct: 374 TIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQ-ILADLENHALFKNDLECQKLILE 432
Query: 259 YCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDT 318
+ P+ + +Q+ + +PRK LYAVGG +++ + +E++D
Sbjct: 433 AMKYHLLPERR---TLMQSPRTKPRKSTVGTLYAVGG--------MDNNKGATTIEKYDL 481
Query: 319 FSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNH 378
+ W ++ R GV V+ ++ IGG + ECY+P TK WT + M+
Sbjct: 482 RTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMST 541
Query: 379 PRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGL 438
R GLGV V G IYA+GG G NT+ER+DP +W V +M+++R G + G
Sbjct: 542 HRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGK 601
Query: 439 IYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGW----- 493
+Y +GG L S E YDP + +W+ PM RR +GVA + +Y+VGG
Sbjct: 602 LYSVGGRDGSSC-LSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPAS 660
Query: 494 NETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTL 553
N L VE+Y + + W VA + +PR + V + LY GG + L
Sbjct: 661 NHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGG------YDGQTYL 714
Query: 554 DSVEVYNPHSDTWTEIGNMITSRCEGGVAVL 584
+++E Y+P ++ WT++ ++ R V V+
Sbjct: 715 NTMESYDPQTNEWTQMASLNIGRAGACVVVI 745
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 313 bits (802), Expect = 3e-85
Identities = 192/560 (34%), Positives = 288/560 (51%), Gaps = 18/560 (3%)
Query: 27 INKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVVPILGIEAG 86
+N++R+ Q CDV + +AHR+VLAA SPYF A+FTG M ES + I ++
Sbjct: 40 MNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQ 99
Query: 87 IFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLNCIGIFQFS 146
L+D+IYT + + NVQ L+ AA +LQL +V CC+FL+ Q+ P NC+GI F+
Sbjct: 100 TLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFA 159
Query: 147 EQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQ 206
+ C DLL+ + Y HF EV GEEFL+L+ DQ+ ++ S++L++ E +VF A +
Sbjct: 160 DVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVIS 219
Query: 207 WILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKEYCEVCKSP 266
WI + R +H+ ++++ +R PLLP L++ +E + + L E + P
Sbjct: 220 WINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLLP 279
Query: 267 KENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTV 326
+ + +K R K + VGG +A+ VE +D W +
Sbjct: 280 LDQRLLIKNPRTKPRTPVSLPKVMIVVGGQA---------PKAIRSVECYDFEEDRWDQI 330
Query: 327 SSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVC 386
+ L R GV + G VYA+GG S+ + YD V QWT++ASM R LG
Sbjct: 331 AELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAA 390
Query: 387 VCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGIS 446
V +YA+GG+ G+ ++E + N+W V M R G ++G +Y +GG
Sbjct: 391 VLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYD 450
Query: 447 NEGIE-LRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEK 505
+ L + E Y+P + W + M TRR+ GV L+ +Y+ GG ++ +VE
Sbjct: 451 GASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGG-HDGPLVRKSVEV 509
Query: 506 YSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDT 565
Y W +VA M + R V AVNGLLYV GG S + L SVE YNP +D
Sbjct: 510 YDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCN------LASVEYYNPVTDK 563
Query: 566 WTEI-GNMITSRCEGGVAVL 584
WT + NM T R GVAV+
Sbjct: 564 WTLLPTNMSTGRSYAGVAVI 583
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 311 bits (798), Expect = 8e-85
Identities = 190/560 (33%), Positives = 291/560 (51%), Gaps = 24/560 (4%)
Query: 27 INKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVVPILGIEAG 86
+ ++R CDV L++G F AHR+VLAAS PYF A+FT M E +D + + G++
Sbjct: 28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPS 87
Query: 87 IFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLNCIGIFQFS 146
+ L++F Y G + I NVQ L++ A LQL + CC FL+ ++ P NC+G+ QF+
Sbjct: 88 ALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFA 147
Query: 147 EQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQ 206
E + C L + + ++IH HF+EV EEFLAL + +++++ +EL+++ E QVF AA+
Sbjct: 148 ETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALA 207
Query: 207 WILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKEYCEVCKSP 266
W+ D +R ++ E+L IR PL PQ L ++ + L+ E + P
Sbjct: 208 WVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMP 267
Query: 267 KENKFCSFLQTSKVRPR--KKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWT 324
+ L + RPR +YAVGG S +L+ VE FD + W
Sbjct: 268 ERR---PHLPAFRTRPRCCTSIAGLIYAVGGLN-------SAGDSLNVVEVFDPIANCWE 317
Query: 325 TVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLG 384
+ ARS +GV V+ G++YAIGG + E Y+P T WT V SMN R +G
Sbjct: 318 RCRPMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMG 377
Query: 385 VCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGG 444
V G IY GG+ G +++E + P+ +KW VV +M+ +R G +G IYV GG
Sbjct: 378 TVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGG 437
Query: 445 ISNEGIEL-RSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTV 503
++G+++ S E Y+ + W P M +R G A+L ++ GG+ + L
Sbjct: 438 --HDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGY-DGSGFLSIA 494
Query: 504 EKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHS 563
E YS ++W + M R+ + +VA G LY GG + L SVE+Y+P +
Sbjct: 495 EMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGG------YDGQSNLSSVEMYDPET 548
Query: 564 DTWTEIGNMITSRCEGGVAV 583
D WT + M EGGV V
Sbjct: 549 DCWTFMAPMACH--EGGVGV 566
Score = 120 bits (300), Expect = 5e-27
Identities = 83/245 (33%), Positives = 118/245 (48%), Gaps = 22/245 (8%)
Query: 351 EKDSMIFDCTECYDPV--TKQWTTV--------ASMNHPRCGLGVCVCYGAIYALGGWVG 400
++D ++ C +C D V K + + A PRC + G IYA+GG
Sbjct: 242 QQDDLVRCCHKCRDLVDEAKDYHLMPERRPHLPAFRTRPRCCTSIA---GLIYAVGGLNS 298
Query: 401 A-EIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYD 459
A + N +E FDP N WE M +R G + GL+Y IGG + + L + E Y+
Sbjct: 299 AGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDGQ-LRLSTVEAYN 357
Query: 460 PLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASM 519
P + W+ + M ++R+ +G L+ IY GG+ + +L +VE YS E +KW V SM
Sbjct: 358 PETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGY-DGNSSLSSVETYSPETDKWTVVTSM 416
Query: 520 KVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEG 579
R+ V G +YVSGG HD L SVE YN H+ TW M+ RC
Sbjct: 417 SSNRSAAGVTVFEGRIYVSGG----HDGLQ--IFSSVEHYNHHTATWHPAAGMLNKRCRH 470
Query: 580 GVAVL 584
G A L
Sbjct: 471 GAASL 475
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 304 bits (779), Expect = 1e-82
Identities = 174/530 (32%), Positives = 280/530 (52%), Gaps = 24/530 (4%)
Query: 52 RLVLAASSPYFAALFTGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELI 111
RLVL++ S YFAA+FT ++E+ ++ + + G+E L+ + YTG + + +N++ L+
Sbjct: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
Query: 112 IAADMLQLTEVVHLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHS 171
A +LQL++VV CC+FL Q+ P NC+GI F++ C DL + + NY HF+EV
Sbjct: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
Query: 172 GEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLL 231
+EF+ L ++ K+L S++++I +E + A + W+ DL +RRK + ++L IR PLL
Sbjct: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353
Query: 232 PPQRLLKYIEGVSDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLY 291
PQ L +E F + Q L+ E + P+ LQ+ + +PRK L+
Sbjct: 354 APQ-FLADMENNVLFRDDIECQKLIMEAMKYHLLPERR---PMLQSPRTKPRKSTVGTLF 409
Query: 292 AVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGE 351
AVGG +G + +E++D + WT V++++ R GV VL +Y +GG
Sbjct: 410 AVGGMDSTKGA--------TSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGR 461
Query: 352 KDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFD 411
+ ECY+P TK W+ + M+ R GLGV V G +YA+GG G NT+ER+D
Sbjct: 462 DGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWD 521
Query: 412 PDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPM 471
P +W V M+ R G + G +Y +GG L+S E +DP + +W+ M
Sbjct: 522 PQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSC-LKSVECFDPHTNKWTLCAQM 580
Query: 472 GTRRAYLGVAALNDCIYSVGGW-----NETQDALHTVEKYSFEEEKWVEVASMKVPRAGM 526
RR +GV N +Y++GG N T VE+Y + + W VASM + R +
Sbjct: 581 SKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAV 640
Query: 527 CVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSR 576
V + LY GG + L++VE Y+P ++ WT++ + R
Sbjct: 641 GVCLLGDKLYAVGG------YDGQAYLNTVEAYDPQTNEWTQVAPLCLGR 684
Score = 73.9 bits (180), Expect = 4e-13
Identities = 44/123 (35%), Positives = 60/123 (48%), Gaps = 5/123 (4%)
Query: 263 CKSPKENKFCSFLQTSKVRPRKKARKY---LYAVGGYTRLQGGRWSDSRALSCVERFDTF 319
C P NK+ Q SK R + LYA+GG+ SR CVER+D
Sbjct: 566 CFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNL--TSRLSDCVERYDPK 623
Query: 320 SQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHP 379
+ WT V+S+ +R +GV +LG +YA+GG + E YDP T +WT VA +
Sbjct: 624 TDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLG 683
Query: 380 RCG 382
R G
Sbjct: 684 RAG 686
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 303 bits (777), Expect = 2e-82
Identities = 193/574 (33%), Positives = 286/574 (49%), Gaps = 27/574 (4%)
Query: 19 HAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVV 78
H++ +L +N +R CD+ L+VG AH++VLA+ SPYF A+FTG + E V
Sbjct: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEV 76
Query: 79 PILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLN 138
I+ Q ++++ YTG V I + V+ L+ AA++LQ+ V+ CC FL+ Q+DP N
Sbjct: 77 EFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGN 136
Query: 139 CIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEY 198
CIGI +F+E C DL + YI +F V EEF LT L +I+ ++ L++ E
Sbjct: 137 CIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEE 196
Query: 199 QVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKE 258
VF A WI D+ +R+K++ ++L+ +R PLL + L + E + LL E
Sbjct: 197 TVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNE 256
Query: 259 YCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDT 318
+ P+ S RPR A K L AVGG + L L VE +
Sbjct: 257 ALKYHFMPEHR--LSHQTVLMTRPR-CAPKVLCAVGGKSGL-------FACLDSVEMYFP 306
Query: 319 FSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCT--------ECYDPVTKQW 370
+ W ++ L+ R G+ VL VY IGG ++ T EC++P T W
Sbjct: 307 QNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTW 366
Query: 371 TTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYF 430
T++ MN R LGV V G +YALGG+ G ++E++ P KW+ V M +R F
Sbjct: 367 TSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCF 426
Query: 431 GCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSV 490
+ G+IY IGG + S E YDP W + M +R + GV + I+ V
Sbjct: 427 AAAVLDGMIYAIGGYG--PAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVV 484
Query: 491 GGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAP 550
GG N L ++E+Y + +W MK PR G+ ++ LYV GG S S
Sbjct: 485 GGHNGVSH-LSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGS------ 537
Query: 551 GTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAVL 584
L++V+ Y+P SDTW + MI RC G+ L
Sbjct: 538 SYLNTVQKYDPISDTWLDSAGMIYCRCNFGLTAL 571
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 289 bits (740), Expect = 4e-78
Identities = 177/553 (32%), Positives = 281/553 (50%), Gaps = 18/553 (3%)
Query: 32 NGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVVPILGIEAGIFQIL 91
NG+ CDV L+VG + H+LVLA PYF A+F M E+ + ++ I + + L
Sbjct: 63 NGE-LCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDL 121
Query: 92 LDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLNCIGIFQFSEQIAC 151
+ F+Y+ + + V+NVQ L+ AA +LQ+ V CCE++K P NC+ + F+E
Sbjct: 122 VKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNR 181
Query: 152 HDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQWILKD 211
DL++ ++ Y HF EV E+F++++ L K+L S +L+IE+E QV+ AA++W+L +
Sbjct: 182 IDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLAN 241
Query: 212 LGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKEYCEVCKSPKENKF 271
K + E L +R PLLP L+ + + + LL E
Sbjct: 242 PQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSRAV 301
Query: 272 CSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQ 331
F + + PRK L+ VGG +GG R++ C + W ++
Sbjct: 302 PDFEYSIRTTPRKHTAGVLFCVGG----RGGSGDPFRSIEC---YSINKNSWFFGPEMNS 354
Query: 332 ARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGA 391
R +GV + G VYA+GG + E +DP+T +W ASMN R G+ + G
Sbjct: 355 RRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGP 414
Query: 392 IYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGI- 450
IYA+GG N +ER+D + ++W V M R G + +Y +GG N+G+
Sbjct: 415 IYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGG--NDGMA 472
Query: 451 ELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEE 510
L S E YDP +W + MG RRA GV+ L+ C+Y VGG+++ L +VE+Y
Sbjct: 473 SLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDD-NSPLSSVERYDPRS 531
Query: 511 EKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIG 570
KW VA++ PR G+ + V G ++ GG + + L++VE ++P + W +G
Sbjct: 532 NKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGN------AYLNTVEAFDPVLNRWELVG 585
Query: 571 NMITSRCEGGVAV 583
++ R GVAV
Sbjct: 586 SVSHCRAGAGVAV 598
Score = 105 bits (262), Expect = 1e-22
Identities = 64/197 (32%), Positives = 103/197 (52%), Gaps = 11/197 (5%)
Query: 390 GAIYALGGWVGA-EIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNE 448
G ++ +GG G+ + +IE + ++N W M R + G ++G +Y +GG ++
Sbjct: 318 GVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGG--HD 375
Query: 449 GIE-LRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYS 507
G E L S E++DPL+ +W M T+R + +A+L IY++GG ++ + VE+Y
Sbjct: 376 GNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNT-CFNDVERYD 434
Query: 508 FEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWT 567
E ++W VA M PR G+ VA+ +Y GG +L SVE Y+PH D W
Sbjct: 435 IESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGM------ASLSSVERYDPHLDKWI 488
Query: 568 EIGNMITSRCEGGVAVL 584
E+ M R GV+ L
Sbjct: 489 EVKEMGQRRAGNGVSKL 505
Score = 76.6 bits (187), Expect = 6e-14
Identities = 37/99 (37%), Positives = 54/99 (54%), Gaps = 8/99 (8%)
Query: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
LY VGG+ D+ LS VER+D S W V++L R G+G+ + G ++A+G
Sbjct: 509 LYVVGGF--------DDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVG 560
Query: 350 GEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVC 388
G + + E +DPV +W V S++H R G GV VC
Sbjct: 561 GHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVC 599
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 280 bits (715), Expect = 3e-75
Identities = 172/517 (33%), Positives = 268/517 (51%), Gaps = 18/517 (3%)
Query: 70 MKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEF 129
M ES V I ++ ++L+D++YT + + NVQ L+ AA +LQL +V CCEF
Sbjct: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
Query: 130 LKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRS 189
L+ Q+ P+NC+GI F++ AC DLL + Y HF +V EEFL L +Q+ ++ S
Sbjct: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
Query: 190 EELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLR 249
++L+I E +VF A + W+ D R++ + +++ +R PLLP + L++ +E +
Sbjct: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
Query: 250 VALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRA 309
A + L E + P E + +++R K + VGG +A
Sbjct: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQA---------PKA 231
Query: 310 LSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQ 369
+ VE +D + W V+ L R G+ + G+V+A+GG S+ + YDPV Q
Sbjct: 232 IRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQ 291
Query: 370 WTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYY 429
WT+VA+M R LG V G +YA+GG+ G+ +++E ++ N+W V M R
Sbjct: 292 WTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSS 351
Query: 430 FGCCEMQGLIYVIGGISNEGIE-LRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIY 488
G + GL+Y +GG + L + E Y+ + W+ + M TRR+ GV LN+ +Y
Sbjct: 352 VGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLY 411
Query: 489 SVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFL 548
+VGG ++ +VE Y W +VA M + R V AVNGLLYV GG S +
Sbjct: 412 AVGG-HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCN-- 468
Query: 549 APGTLDSVEVYNPHSDTWTEIGN-MITSRCEGGVAVL 584
L SVE YNP +D WT + + M T R GV V+
Sbjct: 469 ----LASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVI 501
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 259 bits (662), Expect = 5e-69
Identities = 174/567 (30%), Positives = 283/567 (49%), Gaps = 28/567 (4%)
Query: 13 PFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKE 72
P K + + N++R CDV ++V F AH+ +L + S YF ALFT G
Sbjct: 15 PHMERKMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNN 74
Query: 73 SSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKG 132
+ K V I GI + ++++++ YT V I +NV++L+ AAD + +V CCEFLK
Sbjct: 75 TEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKS 134
Query: 133 QIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLE-VHSGEEFLALTKDQLIKILRSEE 191
++ NCIGI +F++ C +L + + +I +F E V EFL L+ +L I+ +E
Sbjct: 135 ELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDE 194
Query: 192 LSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIE-----GVSDF 246
L+++ E VF A ++WI D R++H+ +L +R L+ + + ++ S+
Sbjct: 195 LNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEE 254
Query: 247 NLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSD 306
V + L Y P + F + L RPR L+A+GG WS
Sbjct: 255 CKPVIINALKAMYDLNMNGPSNSDFTNPL----TRPR-LPYAILFAIGG--------WSG 301
Query: 307 SRALSCVERFDTFSQYWTTVSSLHQA-RSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDP 365
+ +E +D + W V+ ++ R+ G L G VY IGG F+ + +DP
Sbjct: 302 GSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDP 361
Query: 366 VTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAV 425
V K W VA M+ RC + V V IYA+GG+ G NT ER++P+ N+W ++ M
Sbjct: 362 VKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHE 421
Query: 426 SRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALND 485
R + G +Y+ GG + L + EVY+ S +W+ + PM +RR+ +GV A +
Sbjct: 422 QRSDASATTLYGKVYICGGFNGNEC-LFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGE 480
Query: 486 CIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSH 545
+Y+VGG+ + + L + E YS W + +M PR+ + V+ LL+V GG
Sbjct: 481 HVYAVGGF-DGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGG----- 534
Query: 546 DFLAPGTLDSVEVYNPHSDTWTEIGNM 572
F T +VE Y+ +D W + +M
Sbjct: 535 -FNGFTTTFNVECYDEKTDEWYDAHDM 560
Score = 116 bits (291), Expect = 5e-26
Identities = 71/242 (29%), Positives = 111/242 (45%), Gaps = 9/242 (3%)
Query: 344 MVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNH-PRCGLGVCVCYGAIYALGGWVGAE 402
+++AIGG + E YD +W V PR G G +Y +GG+ +
Sbjct: 292 ILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVD 351
Query: 403 IGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLS 462
N+++RFDP + W V M R Y + IY +GG + L + E Y+P +
Sbjct: 352 YFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGY-VRLNTAERYEPET 410
Query: 463 KRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVP 522
+W+ + PM +R+ L +Y GG+N + L T E Y+ E +W +A M+
Sbjct: 411 NQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNE-CLFTAEVYNTESNQWTVIAPMRSR 469
Query: 523 RAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVA 582
R+G+ V+A +Y GG F L S E Y+P ++TW I M R G+
Sbjct: 470 RSGIGVIAYGEHVYAVGG------FDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIE 523
Query: 583 VL 584
V+
Sbjct: 524 VV 525
Score = 84.0 bits (206), Expect = 4e-16
Identities = 42/140 (30%), Positives = 69/140 (49%)
Query: 302 GRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTE 361
G ++ + L E ++T S WT ++ + RSG+GV G VYA+GG + E
Sbjct: 439 GGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAE 498
Query: 362 CYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVG 421
Y PV W T+ +M +PR G+ V ++ +GG+ G +E +D ++W
Sbjct: 499 AYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAH 558
Query: 422 NMAVSRYYFGCCEMQGLIYV 441
+M++ R CC + GL V
Sbjct: 559 DMSIYRSALSCCVVPGLANV 578
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 247 bits (631), Expect = 2e-65
Identities = 174/582 (29%), Positives = 272/582 (46%), Gaps = 61/582 (10%)
Query: 8 KAADSPFSSDKHAQLI---LAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAA 64
K + ++ + A+L+ + +N MR + CDV L V + AHR+VLAA+S +F
Sbjct: 12 KKTEKKLAAREEAKLLAGFMGVMNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNL 71
Query: 65 LFTGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVH 124
+FT M ES V + E I + L++F YT +++ NNVQ L+ AA+ Q+ V
Sbjct: 72 MFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKK 131
Query: 125 LCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLI 184
+C +FLK Q+D NC+GI +E + C +L ++++IH HF EV+ +EFL L ++
Sbjct: 132 MCVDFLKEQVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVT 191
Query: 185 KILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVS 244
+L + L++ E QV+ AA++W+ D R+ +V++L +RFPL+ L K ++
Sbjct: 192 HLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQA-- 249
Query: 245 DFNLRVALQTLLKEYCEVCK-----------SPKENKFCSFLQTSKVRPRKKARKYLYAV 293
+ L+++ E K SP++ + RPR+K Y A+
Sbjct: 250 --------EPLIQDNPECLKMVISGMRYHLLSPEDREEL----VDGTRPRRKKHDYRIAL 297
Query: 294 GGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKD 353
G ++ Q R+ + + S WT + + R +VY +GG
Sbjct: 298 FGGSQPQSCRYFNPKDYS-----------WTDIRCPFEKRRDAACVFWDNVVYILGG--- 343
Query: 354 SMIFDC--TECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNT----I 407
S +F +CY+ V W + PR L C G IY G G+E+GN+
Sbjct: 344 SQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSG---GSEVGNSALYLF 400
Query: 408 ERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIE---LRSFEVYDPLSKR 464
E +D W +M R G E GLIYV GG + L S EVYDP ++
Sbjct: 401 ECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATET 460
Query: 465 WSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRA 524
W+ L PM R G+ + D I++VGG N L VE Y + +W V+ M
Sbjct: 461 WTELCPMIEARKNHGLVFVKDKIFAVGGQNGL-GGLDNVEYYDIKLNEWKMVSPMPWKGV 519
Query: 525 GMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTW 566
+ AV ++YV G F G L + YN +D W
Sbjct: 520 TVKCAAVGSIVYVLAG------FQGVGRLGHILEYNTETDKW 555
Score = 75.5 bits (184), Expect = 1e-13
Identities = 49/172 (28%), Positives = 78/172 (45%), Gaps = 4/172 (2%)
Query: 410 FDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLP 469
F+P + W + R C ++Y++GG ++ ++ + Y+ + W
Sbjct: 309 FNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGG--SQLFPIKRMDCYNVVKDSWYSKL 366
Query: 470 PMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVV 529
T R L A IY+ GG AL+ E Y E W SM R +V
Sbjct: 367 GPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMV 426
Query: 530 AVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGV 581
NGL+YV GG ++ ++ L+S EVY+P ++TWTE+ MI +R G+
Sbjct: 427 EANGLIYVCGGSLGNN--VSGRVLNSCEVYDPATETWTELCPMIEARKNHGL 476
>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
Length = 564
Score = 241 bits (614), Expect = 2e-63
Identities = 168/550 (30%), Positives = 257/550 (46%), Gaps = 58/550 (10%)
Query: 37 CDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVVPILGIEAGIFQILLDFIY 96
CDV L V + AHR+VLAA+S +F +FT M ES V + E I + L++F Y
Sbjct: 22 CDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAY 81
Query: 97 TGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLE 156
T +++ NNVQ L+ AA+ Q+ V +C +FLK Q+D NC+GI +E + C +L
Sbjct: 82 TARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELKA 141
Query: 157 FSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQWILKDLGKRR 216
++++IH HF EV+ +EFL L ++ +L + L++ E QV+ AA++W+ D R+
Sbjct: 142 TADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQ 201
Query: 217 KHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKEYCEVCK-----------S 265
+V++L +RFPL+ L K ++ + L+++ E K S
Sbjct: 202 PFMVDILAKVRFPLISKNFLSKTVQA----------EPLIQDNPECLKMVISGMRYHLLS 251
Query: 266 PKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTT 325
P++ + RPR+K Y A+ G ++ Q R+ + + S WT
Sbjct: 252 PEDREEL----VDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYS-----------WTD 296
Query: 326 VSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDC--TECYDPVTKQWTTVASMNHPRCGL 383
+ + R +VY +GG S +F +CY+ V W + PR L
Sbjct: 297 IRCPFEKRRDAACVFWDNVVYILGG---SQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSL 353
Query: 384 GVCVCYGAIYALGGWVGAEIGNT----IERFDPDENKWEVVGNMAVSRYYFGCCEMQGLI 439
C G IY G G+E+GN+ E +D W +M R G E GLI
Sbjct: 354 AACAAEGKIYTSG---GSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLI 410
Query: 440 YVIGGISNEGIE---LRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNET 496
YV GG + L S EVYDP ++ W+ L PM R G+ + D I++VGG N
Sbjct: 411 YVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGL 470
Query: 497 QDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSV 556
L VE Y + +W V+ M + AV ++YV G F G L +
Sbjct: 471 -GGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAG------FQGVGRLGHI 523
Query: 557 EVYNPHSDTW 566
YN +D W
Sbjct: 524 LEYNTETDKW 533
Score = 75.5 bits (184), Expect = 1e-13
Identities = 49/172 (28%), Positives = 78/172 (45%), Gaps = 4/172 (2%)
Query: 410 FDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLP 469
F+P + W + R C ++Y++GG ++ ++ + Y+ + W
Sbjct: 287 FNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGG--SQLFPIKRMDCYNVVKDSWYSKL 344
Query: 470 PMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVV 529
T R L A IY+ GG AL+ E Y E W SM R +V
Sbjct: 345 GPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMV 404
Query: 530 AVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGV 581
NGL+YV GG ++ ++ L+S EVY+P ++TWTE+ MI +R G+
Sbjct: 405 EANGLIYVCGGSLGNN--VSGRVLNSCEVYDPATETWTELCPMIEARKNHGL 454
>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
Length = 589
Score = 222 bits (565), Expect = 8e-58
Identities = 166/567 (29%), Positives = 253/567 (44%), Gaps = 38/567 (6%)
Query: 14 FSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKES 73
F H +LA +N +R F DV L G +F HR VLAASS YF A+F+ G++ES
Sbjct: 23 FHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRES 82
Query: 74 SKDVVPIL-GIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKG 132
D V + + ++LLDF Y+ + I N + L+ A DMLQ +V EFL+
Sbjct: 83 RDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEK 142
Query: 133 QIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEEL 192
+ P NC+G+ S+ C L EFS VHF V E+F +L+KD L+ ++ S+EL
Sbjct: 143 NLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDEL 202
Query: 193 SIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVAL 252
EDE VF A +QW+ DL R+ H+ E+L +R LLP L E VS L +A
Sbjct: 203 ETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQ---EAVSSEALLMAD 259
Query: 253 Q--TLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWS-DSRA 309
+ L+ + CK+ + + + + RPR KA L +GG T + + D +A
Sbjct: 260 ERTKLIMDEALRCKT-RILQNDGVVTSPCARPR-KAGHTLLILGGQTFMCDKIYQVDHKA 317
Query: 310 LSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGE-KDSMIFDCTECYDPVTK 368
+ + D L R + +G VY GG ++ + YD V +
Sbjct: 318 KEIIPKAD-----------LPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHE 366
Query: 369 QWTTVASMNHPRCGLGVCVCYGAIYALGGWVG---------AEIGNTIERFDPDENKWEV 419
+W+ A M R G G +Y +GG + +E++DP NKW +
Sbjct: 367 EWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMM 426
Query: 420 VGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLG 479
V + + ++V GG S + + YDP RW+ Y
Sbjct: 427 VAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTA 486
Query: 480 VAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSG 539
A L I+ +GG +T+ + ++ E +W + M R +A LYV G
Sbjct: 487 AAVLGSQIFIMGG--DTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVG 544
Query: 540 GRSSSHDFLAPGTLDSVEVYNPHSDTW 566
G + +++ Y+P SDTW
Sbjct: 545 G------YFGTQRCKTLDCYDPTSDTW 565
Score = 52.0 bits (123), Expect = 2e-06
Identities = 31/128 (24%), Positives = 51/128 (39%), Gaps = 5/128 (3%)
Query: 301 GGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCT 360
GG +S V+ +D WT + Q VLG ++ +GG+ + F
Sbjct: 450 GGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGGDTE---FTAA 506
Query: 361 ECY--DPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWE 418
Y D T QWT + M R +Y +GG+ G + T++ +DP + W
Sbjct: 507 SAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWN 566
Query: 419 VVGNMAVS 426
+ + S
Sbjct: 567 CITTVPYS 574
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 219 bits (559), Expect = 4e-57
Identities = 156/578 (26%), Positives = 275/578 (47%), Gaps = 29/578 (5%)
Query: 4 EDCPKAADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQ--ESFKAHRLVLAASSPY 61
+ C F+S+ H+ ++L +++R CDV L G E F HR ++A++S Y
Sbjct: 17 QPCKAGTTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDY 76
Query: 62 FAALFTGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTE 121
F A+FTGGMKE + + G+ + ++DFIYT +++ ++N+Q+ + AA LQ+
Sbjct: 77 FKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILP 136
Query: 122 VVHLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKD 181
V+ C FL + NC+ + + + ++ ++ N+I +F + S EFL L +
Sbjct: 137 VLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFE 196
Query: 182 QLIKILRSEELSIEDEYQVFLAAMQWI-LKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYI 240
+L +L S L E ++F AA +W+ L+D R + +++ IRFPL+ PQ L+ Y+
Sbjct: 197 RLAFVLSSNSLKHCTELELFKAACRWLRLED--PRMDYAAKLMKNIRFPLMTPQDLINYV 254
Query: 241 EGVSDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQ 300
+ V LL E P +Q+ + R + +L +GG R Q
Sbjct: 255 QTVDFMRTDNTCVNLLLEASNYQMMPYMQ---PVMQSDRTAIRSDS-THLVTLGGVLRQQ 310
Query: 301 GGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGE-----KDSM 355
+ R +D +Q W +++ + R G+ V+G +Y +GG+ K
Sbjct: 311 LVVSKELR------MYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKT 364
Query: 356 IFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDEN 415
D +DP +W VAS+N R + G +YA+GG A T+E ++P N
Sbjct: 365 AVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMN 424
Query: 416 KWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRR 475
+W V M+ Y GL+Y+ GGI+++ + +DP + +W PM T R
Sbjct: 425 EWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQ-NELMCFDPDTDKWMQKAPMTTVR 483
Query: 476 AYLGVAALNDCIYSVGG----WNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAV 531
+ + D +Y +GG D + + E YS ++W +A+M ++ + V
Sbjct: 484 GLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVF 543
Query: 532 NGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEI 569
+YV GG S ++ + ++ V+ Y+P D W ++
Sbjct: 544 ENKIYVVGGYSWNNRCM----VEIVQKYDPEKDEWHKV 577
Score = 96.7 bits (239), Expect = 5e-20
Identities = 70/231 (30%), Positives = 105/231 (45%), Gaps = 18/231 (7%)
Query: 363 YDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWV-----GAEIGNTIERFDPDENKW 417
YD ++W ++A M+ PR G+ V +Y +GG G +T+ RFDP NKW
Sbjct: 320 YDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKW 379
Query: 418 EVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAY 477
V ++ R +F ++G +Y +GG S G EL + E Y+P WS + M
Sbjct: 380 MQVASLNEKRTFFHLSALKGHLYAVGGRSAAG-ELATVECYNPRMNEWSYVAKMSEPHYG 438
Query: 478 LGVAALNDCIYSVGGWNETQDALHT-VEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLY 536
+Y GG T D + + + +KW++ A M R C+ V LY
Sbjct: 439 HAGTVYGGLMYISGGI--THDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLY 496
Query: 537 VSGGR----SSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAV 583
V GG +S +D + S E Y+P D WT I M+ + + GVAV
Sbjct: 497 VIGGNHFRGTSDYDDVL-----SCEYYSPTLDQWTPIAAMLRGQSDVGVAV 542
Score = 54.7 bits (130), Expect = 2e-07
Identities = 50/215 (23%), Positives = 86/215 (40%), Gaps = 59/215 (27%)
Query: 266 PKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTT 325
P+ NK+ ++ K+ +L A+ G+ GGR S + L+ VE ++ W+
Sbjct: 374 PRYNKWMQVASLNE----KRTFFHLSALKGHLYAVGGR-SAAGELATVECYNPRMNEWSY 428
Query: 326 VSSLHQARSGLGVTVLGGMVYAIGG------EKDSMIFD--------------------- 358
V+ + + G TV GG++Y GG + + M FD
Sbjct: 429 VAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCM 488
Query: 359 CT-------------------------ECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIY 393
CT E Y P QWT +A+M + +GV V IY
Sbjct: 489 CTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIY 548
Query: 394 ALGG--WVGAEIGNTIERFDPDENKWEVVGNMAVS 426
+GG W + ++++DP++++W V ++ S
Sbjct: 549 VVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPES 583
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 214 bits (545), Expect = 2e-55
Identities = 153/550 (27%), Positives = 252/550 (45%), Gaps = 54/550 (9%)
Query: 15 SSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESS 74
S HA+ IL N+ R+ + F DV + V + F HR VL+A S YF A+F +ES
Sbjct: 44 SGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESR 103
Query: 75 KDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQI 134
+ +V I GI A + L ++YTG V I NVQ L + + Q++ + C +FL+ Q+
Sbjct: 104 EMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQL 163
Query: 135 DPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSI 194
DP NC+GI +F++ + L +N+ F +V EEFL L KD+LI + S+EL I
Sbjct: 164 DPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVI 223
Query: 195 EDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQT 254
E VF A M+W+ + + RR + E+L +R PLL P ++ +E + +Q
Sbjct: 224 GKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVE------VDQLIQN 277
Query: 255 LLKEYCEVCKSPKENKFCSFLQTSKVRPRKKA--RKYLYAVGGYTRLQG----------- 301
+ Y + ++ + + + + + + RPR+ + + VGG R+ G
Sbjct: 278 SPECYQLLHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDP 337
Query: 302 --GRW---------SDSRALSCVER-----------------FDTFSQYWTTVSSLHQAR 333
G W + S C R +++ W V+SL++ R
Sbjct: 338 VTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINSRDVWIYNSQLNIWIRVASLNKGR 397
Query: 334 SGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIY 393
+ VL G VY +GG ECYD + +WT VA + V C G ++
Sbjct: 398 WRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLF 457
Query: 394 ALGGWVGAE-IGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIEL 452
+GG + ++ +DP+ N W + + +++ + LIYV GG++
Sbjct: 458 VIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLT------ 511
Query: 453 RSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEK 512
++ YDP+ W + +R+ G++ N IY +GG E +A T+ Y
Sbjct: 512 KAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATSI 571
Query: 513 WVEVASMKVP 522
VA+M P
Sbjct: 572 ITGVAAMPRP 581
Score = 73.2 bits (178), Expect = 6e-13
Identities = 57/196 (29%), Positives = 82/196 (41%), Gaps = 14/196 (7%)
Query: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
+Y VGGY LS VE +D+FS WT V+ L +A S VT G ++ IG
Sbjct: 409 VYVVGGY--------DGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIG 460
Query: 350 G-EKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIE 408
G D+ D + YDP T W A++ + + IY GG A I
Sbjct: 461 GGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKA-----IY 515
Query: 409 RFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPL 468
+DP E+ W V N + G G IY++GG G + YDP + + +
Sbjct: 516 CYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATSIITGV 575
Query: 469 PPMGTRRAYLGVAALN 484
M +Y G ++
Sbjct: 576 AAMPRPVSYHGCVTIH 591
>gi|55925608 kelch-like 21 [Homo sapiens]
Length = 597
Score = 213 bits (542), Expect = 4e-55
Identities = 157/567 (27%), Positives = 255/567 (44%), Gaps = 38/567 (6%)
Query: 13 PFSSDKHAQLILAQINKMRNGQHFCDVQLQV-GQESFKAHRLVLAASSPYFAALFTGGMK 71
PFS HA +L ++++R + F DV L+ G F AHR VLAA+SPYF A+F G ++
Sbjct: 11 PFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLR 70
Query: 72 ESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLK 131
ES + V + G+ + Q+LLDF YTG V + +N + L+ AAD+LQ V C FL+
Sbjct: 71 ESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQ 130
Query: 132 GQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEE 191
Q+D NC+ + F+E +C L ++ +I H E+ E+ L +L++ LR +
Sbjct: 131 QQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGEL-GAEQLERLPLARLLRYLRDDG 189
Query: 192 LSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVA 251
L + E + A++W+ D +R H ++L+ +R P + LL ++E
Sbjct: 190 LCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPP 249
Query: 252 LQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALS 311
LL+E + + + + RP + L VGG + D L
Sbjct: 250 CLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQ-------DCDELV 302
Query: 312 CVERFDTFSQYWTTVSSL-HQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQW 370
V+ ++ + W ++ G + LG +Y GG S ++DC Y+ +W
Sbjct: 303 TVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEW 362
Query: 371 TTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYF 430
VA M R V G +Y + ++ ER+D + WE + M
Sbjct: 363 AEVAPMLKAREYHSSSVLDGLLYVVA-------ADSTERYDHTTDSWEALQPMTYPMDNC 415
Query: 431 GCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWS-----PLPPMGTRRAYLGVAALND 485
+G +Y IG ++ G E + YDP + WS LPP A LN
Sbjct: 416 STTACRGRLYAIGSLA--GKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPK---TATLNG 470
Query: 486 CIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSH 545
+Y V +D V+ Y+ +W ++ SM G + + G LYVSGG ++
Sbjct: 471 LMYFV------RDDSAEVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTF 524
Query: 546 DFLAPGTLDSVEVYNPHSDTWTEIGNM 572
+ D VE Y+P + W+ +G +
Sbjct: 525 EL-----SDVVEAYDPETRAWSVVGRL 546
Score = 75.1 bits (183), Expect = 2e-13
Identities = 62/250 (24%), Positives = 103/250 (41%), Gaps = 25/250 (10%)
Query: 339 TVLGGMVYAIGG-EKDSMIFDCTECYDPVTKQWTTVASM-NHPRCGLGVCVCYGAIYALG 396
T L ++ +GG ++D +CY+P T QW +A +H G + IY G
Sbjct: 282 TGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTG 341
Query: 397 GWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFE 456
G G+ + + + R++ N+W V M +R Y + GL+YV+ S E
Sbjct: 342 GSDGSRLYDCVWRYNSSVNEWAEVAPMLKAREYHSSSVLDGLLYVVAADSTER------- 394
Query: 457 VYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEV 516
YD + W L PM A +Y++G + + ++ Y + + W V
Sbjct: 395 -YDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETMV--MQCYDPDTDLWSLV 451
Query: 517 ASMKVPRAGMC--VVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMIT 574
++P +NGL+Y S+ V+VYNP + W +I +M
Sbjct: 452 DCGQLPPWSFAPKTATLNGLMYFVRDDSAE-----------VDVYNPTRNEWDKIPSMNQ 500
Query: 575 SRCEGGVAVL 584
G +AVL
Sbjct: 501 VHVGGSLAVL 510
Score = 53.1 bits (126), Expect = 7e-07
Identities = 35/167 (20%), Positives = 58/167 (34%), Gaps = 44/167 (26%)
Query: 309 ALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGG--EKDSMIFDC------- 359
A ER+D + W + + T G +YAIG K++M+ C
Sbjct: 388 AADSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETMVMQCYDPDTDL 447
Query: 360 ----------------------------------TECYDPVTKQWTTVASMNHPRCGLGV 385
+ Y+P +W + SMN G +
Sbjct: 448 WSLVDCGQLPPWSFAPKTATLNGLMYFVRDDSAEVDVYNPTRNEWDKIPSMNQVHVGGSL 507
Query: 386 CVCYGAIYALGGWVGA-EIGNTIERFDPDENKWEVVGNMAVSRYYFG 431
V G +Y GG+ E+ + +E +DP+ W VVG + ++ G
Sbjct: 508 AVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRLPEPTFWHG 554
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 212 bits (540), Expect = 7e-55
Identities = 156/573 (27%), Positives = 265/573 (46%), Gaps = 60/573 (10%)
Query: 14 FSSDKHAQLILAQINKMRNGQHFCDVQLQVGQ--ESFKAHRLVLAASSPYFAALFTGGMK 71
F+S+ H+ ++L +++R CDV L G ++F HR+++A++S YF A+FTGGMK
Sbjct: 69 FTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMK 128
Query: 72 ESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLK 131
E + + G+ + ++DFIYT +++ ++N+Q+ + AA LQ+ V+ C FL
Sbjct: 129 EQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLI 188
Query: 132 GQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEE 191
+ NC+ + + + ++ ++ +++ +F + S EFL L ++L +L S
Sbjct: 189 SGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNS 248
Query: 192 LSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGV-------- 243
L E ++F A +W+ + R +++ IRFPL+ PQ L+ Y++ V
Sbjct: 249 LKHCTELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNT 307
Query: 244 -----------------------------SDFNLRVALQTLLKEYCEVCK-----SPKEN 269
SD V L +L++ V K K +
Sbjct: 308 CVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAH 367
Query: 270 KFCSFLQTSKVRPRKKAR---KYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTV 326
++ S R + +LY VGG + A+ V RFD W V
Sbjct: 368 EWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYD---TKGKTAVDTVFRFDPRYNKWMQV 424
Query: 327 SSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVC 386
+SL++ R+ ++ L G +YA+GG + ECY+P T +WT VA M+ P G
Sbjct: 425 ASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGT 484
Query: 387 VCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGIS 446
V G +Y GG + FDPD +KW M R C + +YVIGG
Sbjct: 485 VYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNH 544
Query: 447 NEGI----ELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGG--WNETQDAL 500
G ++ S E Y P+ +W+P+ M ++ +GVA + IY VGG WN + +
Sbjct: 545 FRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWN-NRCMV 603
Query: 501 HTVEKYSFEEEKWVEVASMKVPRAGM--CVVAV 531
V+KY ++++W +V + G+ C + V
Sbjct: 604 EIVQKYDPDKDEWHKVFDLPESLGGIRACTLTV 636
Score = 94.7 bits (234), Expect = 2e-19
Identities = 68/231 (29%), Positives = 105/231 (45%), Gaps = 18/231 (7%)
Query: 363 YDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWV-----GAEIGNTIERFDPDENKW 417
YD +W ++A M+ PR G+ V +Y +GG G +T+ RFDP NKW
Sbjct: 362 YDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKW 421
Query: 418 EVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAY 477
V ++ R +F ++G +Y +GG + G EL + E Y+P + W+ + M
Sbjct: 422 MQVASLNEKRTFFHLSALKGYLYAVGGRNAAG-ELPTVECYNPRTNEWTYVAKMSEPHYG 480
Query: 478 LGVAALNDCIYSVGGWNETQDALHT-VEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLY 536
+Y GG T D + + + +KW++ A M R C+ V LY
Sbjct: 481 HAGTVYGGVMYISGGI--THDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLY 538
Query: 537 VSGGR----SSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAV 583
V GG +S +D + S E Y+P D WT I M+ + + GVAV
Sbjct: 539 VIGGNHFRGTSDYDDVL-----SCEYYSPILDQWTPIAAMLRGQSDVGVAV 584
Score = 73.6 bits (179), Expect = 5e-13
Identities = 42/139 (30%), Positives = 71/139 (51%), Gaps = 11/139 (7%)
Query: 439 IYVIGGISNEGIEL-RSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWN--- 494
+ +GG+ + + + + +YD + W L PM R G+A + + +Y VGG +
Sbjct: 342 LVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYD 401
Query: 495 -ETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTL 553
+ + A+ TV ++ KW++VAS+ R + A+ G LY GGR+ A G L
Sbjct: 402 TKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRN------AAGEL 455
Query: 554 DSVEVYNPHSDTWTEIGNM 572
+VE YNP ++ WT + M
Sbjct: 456 PTVECYNPRTNEWTYVAKM 474
>gi|24432026 kelch-like [Homo sapiens]
Length = 634
Score = 211 bits (536), Expect = 2e-54
Identities = 155/575 (26%), Positives = 261/575 (45%), Gaps = 32/575 (5%)
Query: 7 PKAADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALF 66
P ++ + S +H+Q +L + +R+ DV L V +AHR++LAAS YF +F
Sbjct: 20 PHCVNNTYRSAQHSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMF 79
Query: 67 TGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLC 126
GG+KE ++ V I G+ +L FIYT + + ++NVQE ++AA LQ+ E++H C
Sbjct: 80 AGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFC 139
Query: 127 CEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKI 186
C+FL +D N + +++ +E L E + YI +F+ +++ L +++ +
Sbjct: 140 CDFLMSWVDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSL 199
Query: 187 LRSEELSIEDEYQVFLAAM--QWILKDLGKRRKHVVE---VLDPIRFPLLPPQRLLKYIE 241
L S L + E +V+ A+ + L+ + + + E +L+ +RFPL+ + L + +
Sbjct: 200 LSSNRLEVSCETEVYEGALLYHYSLEQVQADQISLHEPPKLLETVRFPLMEAEVLQRLHD 259
Query: 242 GVSDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQG 301
+ LR + + L + LQ S P+ + R V G+ +
Sbjct: 260 KLDPSPLRDTVASALMYHRN-----------ESLQPSLQSPQTELRSDFQCVVGFGGIHS 308
Query: 302 GRWSDSRALSCVERF--DTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDC 359
+ S LS ++ ++ +SL S G+ VL VY IGG+ + F
Sbjct: 309 ---TPSTVLSDQAKYLNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNNVQGFRA 365
Query: 360 -TEC--YDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENK 416
+ C YDP +W + S+ L VCV IYA+ G N +ER+DP N
Sbjct: 366 ESRCWRYDPRHNRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNS 425
Query: 417 WEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRA 476
W V + Y ++G +Y+ G E L+ YDP S W L RRA
Sbjct: 426 WAYVAPLKREVYAHAGATLEGKMYITCGRRGEDY-LKETHCYDPGSNTWHTLADGPVRRA 484
Query: 477 YLGVAALNDCIYSVGGWNET---QDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNG 533
+ G+A L + +Y +GG N + +H V YS +W V + + ++
Sbjct: 485 WHGMATLLNKLYVIGGSNNDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDN 544
Query: 534 LLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTE 568
+YV GGRS + V +Y+ D W E
Sbjct: 545 RIYVLGGRSHNRG----SRTGYVHIYDVEKDCWEE 575
Score = 57.0 bits (136), Expect = 5e-08
Identities = 44/156 (28%), Positives = 67/156 (42%), Gaps = 9/156 (5%)
Query: 431 GCCEMQGLIYVIGGISN-EGIELRS-FEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIY 488
G + +Y+IGG +N +G S YDP RW + + A L V + IY
Sbjct: 343 GIAVLNNFVYLIGGDNNVQGFRAESRCWRYDPRHNRWFQIQSLQQEHADLSVCVVGRYIY 402
Query: 489 SVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFL 548
+V G + D L+ VE+Y W VA +K + G +Y++ GR D+L
Sbjct: 403 AVAGRDYHND-LNAVERYDPATNSWAYVAPLKREVYAHAGATLEGKMYITCGRRGE-DYL 460
Query: 549 APGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAVL 584
Y+P S+TW + + R G+A L
Sbjct: 461 K-----ETHCYDPGSNTWHTLADGPVRRAWHGMATL 491
>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
sapiens]
Length = 589
Score = 209 bits (531), Expect = 7e-54
Identities = 159/576 (27%), Positives = 252/576 (43%), Gaps = 50/576 (8%)
Query: 14 FSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKES 73
F +A +L +N +R + F DV L G +F HR VLAA S YF A+F+GG+KES
Sbjct: 23 FHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKES 82
Query: 74 SKDVVPI-LGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKG 132
V I + ++LLD+ Y+ V I N + L+ A DML+ ++ C EFL+
Sbjct: 83 QDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEK 142
Query: 133 QIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEEL 192
+ P NC+G+ S+ C L E S +F + E+FL L +D ++++L SEEL
Sbjct: 143 NLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEEL 202
Query: 193 SIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVAL 252
EDE V+ +A+ WI DL KR ++ E+L +R LLP L++ VA+
Sbjct: 203 ETEDERLVYESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLME----------NVAM 252
Query: 253 QTLLKEYCEVCKSPKENKFC--SFLQTSKV------RPRKKARKYLYAVGGYTRLQGGRW 304
+ L+ + + + +E C LQ V RPRK L+ +GG T + +
Sbjct: 253 EELITKQRKSKEIVEEAIRCKLKILQNDGVVTSLCARPRKTGHA-LFLLGGQTFMCDKLY 311
Query: 305 -SDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGE-KDSMIFDCTEC 362
D +A + + D + R +G VY GG ++ +
Sbjct: 312 LVDQKAKEIIPKAD-----------IPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWV 360
Query: 363 YDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAE---------IGNTIERFDPD 413
YD + ++W+ A M R G G +Y +GG A +E +DP
Sbjct: 361 YDTLHEEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPT 420
Query: 414 ENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGT 473
NKW +V + + ++ GG S +L + YD RW+
Sbjct: 421 INKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQ 480
Query: 474 RRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNG 533
Y A L + I+ +GG +T+ + + K++ E +W +V + R VA
Sbjct: 481 PWRYTAAAVLGNQIFIMGG--DTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGN 538
Query: 534 LLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEI 569
LYV GG + +++ Y+P D W I
Sbjct: 539 KLYVVGG------YFGIQRCKTLDCYDPTLDVWNSI 568
Score = 47.0 bits (110), Expect = 5e-05
Identities = 30/128 (23%), Positives = 51/128 (39%), Gaps = 5/128 (3%)
Query: 301 GGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCT 360
GG L V+ +D WT ++ Q VLG ++ +GG+ + F
Sbjct: 450 GGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGGDTE---FSAC 506
Query: 361 ECY--DPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWE 418
Y + T QWT V + R +Y +GG+ G + T++ +DP + W
Sbjct: 507 SAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWN 566
Query: 419 VVGNMAVS 426
+ + S
Sbjct: 567 SITTVPYS 574
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.427
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,136,299
Number of Sequences: 37866
Number of extensions: 972074
Number of successful extensions: 3609
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 176
Number of HSP's successfully gapped in prelim test: 20
Number of HSP's that attempted gapping in prelim test: 2034
Number of HSP's gapped (non-prelim): 399
length of query: 584
length of database: 18,247,518
effective HSP length: 108
effective length of query: 476
effective length of database: 14,157,990
effective search space: 6739203240
effective search space used: 6739203240
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.