Search of human proteins with 4885391

Search of human proteins with 4885391

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4885391 hyaluronan synthase 2 [Homo sapiens]
         (552 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4885391 hyaluronan synthase 2 [Homo sapiens]                      1129   0.0  
gi|20302153 hyaluronan synthase 3 isoform a [Homo sapiens]            821   0.0  
gi|167466171 hyaluronan synthase 1 [Homo sapiens]                     619   e-177
gi|20302155 hyaluronan synthase 3 isoform b [Homo sapiens]            313   3e-85
gi|29029605 purinergic receptor P2Y12 [Homo sapiens]                   34   0.40 
gi|12232483 purinergic receptor P2Y12 [Homo sapiens]                   34   0.40 
gi|224586796 G protein-coupled receptor 87 [Homo sapiens]              33   0.52 
gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isofo...    31   2.6  
gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isofor...    31   2.6  
gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isofo...    31   2.6  

>gi|4885391 hyaluronan synthase 2 [Homo sapiens]
          Length = 552

 Score = 1129 bits (2920), Expect = 0.0
 Identities = 552/552 (100%), Positives = 552/552 (100%)

Query: 1   MHCERFLCILRIIGTTLFGVSLLLGITAAYIVGYQFIQTDNYYFSFGLYGAFLASHLIIQ 60
           MHCERFLCILRIIGTTLFGVSLLLGITAAYIVGYQFIQTDNYYFSFGLYGAFLASHLIIQ
Sbjct: 1   MHCERFLCILRIIGTTLFGVSLLLGITAAYIVGYQFIQTDNYYFSFGLYGAFLASHLIIQ 60

Query: 61  SLFAFLEHRKMKKSLETPIKLNKTVALCIAAYQEDPDYLRKCLQSVKRLTYPGIKVVMVI 120
           SLFAFLEHRKMKKSLETPIKLNKTVALCIAAYQEDPDYLRKCLQSVKRLTYPGIKVVMVI
Sbjct: 61  SLFAFLEHRKMKKSLETPIKLNKTVALCIAAYQEDPDYLRKCLQSVKRLTYPGIKVVMVI 120

Query: 121 DGNSEDDLYMMDIFSEVMGRDKSATYIWKNNFHEKGPGETDESHKESSQHVTQLVLSNKS 180
           DGNSEDDLYMMDIFSEVMGRDKSATYIWKNNFHEKGPGETDESHKESSQHVTQLVLSNKS
Sbjct: 121 DGNSEDDLYMMDIFSEVMGRDKSATYIWKNNFHEKGPGETDESHKESSQHVTQLVLSNKS 180

Query: 181 ICIMQKWGGKREVMYTAFRALGRSVDYVQVCDSDTMLDPASSVEMVKVLEEDPMVGGVGG 240
           ICIMQKWGGKREVMYTAFRALGRSVDYVQVCDSDTMLDPASSVEMVKVLEEDPMVGGVGG
Sbjct: 181 ICIMQKWGGKREVMYTAFRALGRSVDYVQVCDSDTMLDPASSVEMVKVLEEDPMVGGVGG 240

Query: 241 DVQILNKYDSWISFLSSVRYWMAFNIERACQSYFGCVQCISGPLGMYRNSLLHEFVEDWY 300
           DVQILNKYDSWISFLSSVRYWMAFNIERACQSYFGCVQCISGPLGMYRNSLLHEFVEDWY
Sbjct: 241 DVQILNKYDSWISFLSSVRYWMAFNIERACQSYFGCVQCISGPLGMYRNSLLHEFVEDWY 300

Query: 301 NQEFMGNQCSFGDDRHLTNRVLSLGYATKYTARSKCLTETPIEYLRWLNQQTRWSKSYFR 360
           NQEFMGNQCSFGDDRHLTNRVLSLGYATKYTARSKCLTETPIEYLRWLNQQTRWSKSYFR
Sbjct: 301 NQEFMGNQCSFGDDRHLTNRVLSLGYATKYTARSKCLTETPIEYLRWLNQQTRWSKSYFR 360

Query: 361 EWLYNAMWFHKHHLWMTYEAIITGFFPFFLIATVIQLFYRGKIWNILLFLLTVQLVGLIK 420
           EWLYNAMWFHKHHLWMTYEAIITGFFPFFLIATVIQLFYRGKIWNILLFLLTVQLVGLIK
Sbjct: 361 EWLYNAMWFHKHHLWMTYEAIITGFFPFFLIATVIQLFYRGKIWNILLFLLTVQLVGLIK 420

Query: 421 SSFASCLRGNIVMVFMSLYSVLYMSSLLPAKMFAIATINKAGWGTSGRKTIVVNFIGLIP 480
           SSFASCLRGNIVMVFMSLYSVLYMSSLLPAKMFAIATINKAGWGTSGRKTIVVNFIGLIP
Sbjct: 421 SSFASCLRGNIVMVFMSLYSVLYMSSLLPAKMFAIATINKAGWGTSGRKTIVVNFIGLIP 480

Query: 481 VSVWFTILLGGVIFTIYKESKRPFSESKQTVLIVGTLLYACYWVMLLTLYVVLINKCGRR 540
           VSVWFTILLGGVIFTIYKESKRPFSESKQTVLIVGTLLYACYWVMLLTLYVVLINKCGRR
Sbjct: 481 VSVWFTILLGGVIFTIYKESKRPFSESKQTVLIVGTLLYACYWVMLLTLYVVLINKCGRR 540

Query: 541 KKGQQYDMVLDV 552
           KKGQQYDMVLDV
Sbjct: 541 KKGQQYDMVLDV 552


>gi|20302153 hyaluronan synthase 3 isoform a [Homo sapiens]
          Length = 553

 Score =  821 bits (2120), Expect = 0.0
 Identities = 385/544 (70%), Positives = 468/544 (86%), Gaps = 9/544 (1%)

Query: 10  LRIIGTTLFGVSLLLGITAAYIVGYQFIQTDNYYFSFGLYGAFLASHLIIQSLFAFLEHR 69
           LR++GT+LF +++L GI AAY+ GYQFI T+ +Y SFGLYGA L  HL+IQSLFAFLEHR
Sbjct: 9   LRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQSLFAFLEHR 68

Query: 70  KMKKS---LETPIKLNKTVALCIAAYQEDPDYLRKCLQSVKRLTYPGIKVVMVIDGNSED 126
           +M+++   L+ P     +VALCIAAYQEDPDYLRKCL+S +R+++P +KVVMV+DGN ++
Sbjct: 69  RMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVVMVVDGNRQE 128

Query: 127 DLYMMDIFSEVMG-RDKSATYIWKNNFHEKGPGETDESHKESSQHVTQLVLSNKSICIMQ 185
           D YM+DIF EV+G  +++  ++W++NFHE G GET+ S +E    V  +V ++   CIMQ
Sbjct: 129 DAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRASTFSCIMQ 188

Query: 186 KWGGKREVMYTAFRALGRSVDYVQVCDSDTMLDPASSVEMVKVLEEDPMVGGVGGDVQIL 245
           KWGGKREVMYTAF+ALG SVDY+QVCDSDT+LDPA ++EM++VLEEDP VGGVGGDVQIL
Sbjct: 189 KWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGGVGGDVQIL 248

Query: 246 NKYDSWISFLSSVRYWMAFNIERACQSYFGCVQCISGPLGMYRNSLLHEFVEDWYNQEFM 305
           NKYDSWISFLSSVRYWMAFN+ERACQSYFGCVQCISGPLGMYRNSLL +F+EDWY+Q+F+
Sbjct: 249 NKYDSWISFLSSVRYWMAFNVERACQSYFGCVQCISGPLGMYRNSLLQQFLEDWYHQKFL 308

Query: 306 GNQCSFGDDRHLTNRVLSLGYATKYTARSKCLTETPIEYLRWLNQQTRWSKSYFREWLYN 365
           G++CSFGDDRHLTNRVLSLGY TKYTARSKCLTETP +YLRWLNQQTRWSKSYFREWLYN
Sbjct: 309 GSKCSFGDDRHLTNRVLSLGYRTKYTARSKCLTETPTKYLRWLNQQTRWSKSYFREWLYN 368

Query: 366 AMWFHKHHLWMTYEAIITGFFPFFLIATVIQLFYRGKIWNILLFLLTVQLVGLIKSSFAS 425
           ++WFHKHHLWMTYE+++TGFFPFFLIATVIQLFYRG+IWNILLFLLTVQLVG+IK+++A 
Sbjct: 369 SLWFHKHHLWMTYESVVTGFFPFFLIATVIQLFYRGRIWNILLFLLTVQLVGIIKATYAC 428

Query: 426 CLRGNIVMVFMSLYSVLYMSSLLPAKMFAIATINKAGWGTSGRKTIVVNFIGLIPVSVWF 485
            LRGN  M+FMSLYS+LYMSSLLPAK+FAIATINK+GWGTSGRKTIVVNFIGLIPVS+W 
Sbjct: 429 FLRGNAEMIFMSLYSLLYMSSLLPAKIFAIATINKSGWGTSGRKTIVVNFIGLIPVSIWV 488

Query: 486 TILLGGVIFTIYKESKRPFSESKQTVLIVGTLLYACYWVMLLTLYVVLI-NKCGRRKKGQ 544
            +LLGG+ +T Y +    FSE++   L+ G +LY CYWV LL LY+ +I  +CG  KK +
Sbjct: 489 AVLLGGLAYTAYCQDL--FSETELAFLVSGAILYGCYWVALLMLYLAIIARRCG--KKPE 544

Query: 545 QYDM 548
           QY +
Sbjct: 545 QYSL 548


>gi|167466171 hyaluronan synthase 1 [Homo sapiens]
          Length = 578

 Score =  619 bits (1596), Expect = e-177
 Identities = 297/554 (53%), Positives = 399/554 (72%), Gaps = 19/554 (3%)

Query: 9   ILRIIGTTLFGVSLLLGITAAYIVGYQFIQTDNYYFSFGLYGAFLASHLIIQSLFAFLEH 68
           + R + T  F + +L  +T AY  G           +FGLYGAFL++HL+ QSLFA+LEH
Sbjct: 19  LARRVLTIAFALLILGLMTWAYAAGVPLASDRYGLLAFGLYGAFLSAHLVAQSLFAYLEH 78

Query: 69  RKMKKSLETPIKLN--KTVALCIAAYQEDPDYLRKCLQSVKRLTYPG--IKVVMVIDGNS 124
           R++  +   P+     ++VAL I+AYQEDP YLR+CL S + L YP   ++V+MV+DGN 
Sbjct: 79  RRVAAAARGPLDAATARSVALTISAYQEDPAYLRQCLASARALLYPRARLRVLMVVDGNR 138

Query: 125 EDDLYMMDIFSEVMGRDKSATYIWKNNFHEK---------GPGETDESHKESSQH--VTQ 173
            +DLYM+D+F EV   +  ATY+W  N+H+          G G   E   E      V  
Sbjct: 139 AEDLYMVDMFREVFADEDPATYVWDGNYHQPWEPAAAGAVGAGAYREVEAEDPGRLAVEA 198

Query: 174 LVLSNKSICIMQKWGGKREVMYTAFRALGRSVDYVQVCDSDTMLDPASSVEMVKVLEEDP 233
           LV + + +C+ Q+WGGKREVMYTAF+ALG SVDYVQVCDSDT LDP + +E+V+VL+EDP
Sbjct: 199 LVRTRRCVCVAQRWGGKREVMYTAFKALGDSVDYVQVCDSDTRLDPMALLELVRVLDEDP 258

Query: 234 MVGGVGGDVQILNKYDSWISFLSSVRYWMAFNIERACQSYFGCVQCISGPLGMYRNSLLH 293
            VG VGGDV+ILN  DSW+SFLSS+RYW+AFN+ERACQSYF CV CISGPLG+YRN+LL 
Sbjct: 259 RVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYFHCVSCISGPLGLYRNNLLQ 318

Query: 294 EFVEDWYNQEFMGNQCSFGDDRHLTNRVLSLGYATKYTARSKCLTETPIEYLRWLNQQTR 353
           +F+E WYNQ+F+G  C+FGDDRHLTNR+LS+GYATKYT+RS+C +ETP  +LRWL+QQTR
Sbjct: 319 QFLEAWYNQKFLGTHCTFGDDRHLTNRMLSMGYATKYTSRSRCYSETPSSFLRWLSQQTR 378

Query: 354 WSKSYFREWLYNAMWFHKHHLWMTYEAIITGFFPFFLIATVIQLFYRGKIWNILLFLLTV 413
           WSKSYFREWLYNA+W+H+HH WMTYEA+++G FPFF+ ATV++LFY G+ W +L  LL V
Sbjct: 379 WSKSYFREWLYNALWWHRHHAWMTYEAVVSGLFPFFVAATVLRLFYAGRPWALLWVLLCV 438

Query: 414 QLVGLIKSSFASCLRGNIVMVFMSLYSVLYMSSLLPAKMFAIATINKAGWGTSGRKTIVV 473
           Q V L K++FA+ LRG + MV +SLY+ LYM  LLPAK  A+ T+N++GWGTSGR+ +  
Sbjct: 439 QGVALAKAAFAAWLRGCLRMVLLSLYAPLYMCGLLPAKFLALVTMNQSGWGTSGRRKLAA 498

Query: 474 NFIGLIPVSVWFTILLGGVIFTIYKESKRPFSESKQTV----LIVGTLLYACYWVMLLTL 529
           N++ L+P+++W  +LLGG++ ++  E++  +S   +      L  G   Y  YWV +LTL
Sbjct: 499 NYVPLLPLALWALLLLGGLVRSVAHEARADWSGPSRAAEAYHLAAGAGAYVGYWVAMLTL 558

Query: 530 YVVLINKCGRRKKG 543
           Y V + +  RR+ G
Sbjct: 559 YWVGVRRLCRRRTG 572


>gi|20302155 hyaluronan synthase 3 isoform b [Homo sapiens]
          Length = 281

 Score =  313 bits (801), Expect = 3e-85
 Identities = 147/238 (61%), Positives = 193/238 (81%), Gaps = 4/238 (1%)

Query: 10  LRIIGTTLFGVSLLLGITAAYIVGYQFIQTDNYYFSFGLYGAFLASHLIIQSLFAFLEHR 69
           LR++GT+LF +++L GI AAY+ GYQFI T+ +Y SFGLYGA L  HL+IQSLFAFLEHR
Sbjct: 9   LRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQSLFAFLEHR 68

Query: 70  KMKKS---LETPIKLNKTVALCIAAYQEDPDYLRKCLQSVKRLTYPGIKVVMVIDGNSED 126
           +M+++   L+ P     +VALCIAAYQEDPDYLRKCL+S +R+++P +KVVMV+DGN ++
Sbjct: 69  RMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVVMVVDGNRQE 128

Query: 127 DLYMMDIFSEVMG-RDKSATYIWKNNFHEKGPGETDESHKESSQHVTQLVLSNKSICIMQ 185
           D YM+DIF EV+G  +++  ++W++NFHE G GET+ S +E    V  +V ++   CIMQ
Sbjct: 129 DAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRASTFSCIMQ 188

Query: 186 KWGGKREVMYTAFRALGRSVDYVQVCDSDTMLDPASSVEMVKVLEEDPMVGGVGGDVQ 243
           KWGGKREVMYTAF+ALG SVDY+QVCDSDT+LDPA ++EM++VLEEDP VGGVGGDVQ
Sbjct: 189 KWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGGVGGDVQ 246


>gi|29029605 purinergic receptor P2Y12 [Homo sapiens]
          Length = 342

 Score = 33.9 bits (76), Expect = 0.40
 Identities = 42/162 (25%), Positives = 66/162 (40%), Gaps = 27/162 (16%)

Query: 388 FFLIATVIQLFYRGKIWNILLFLLTVQLVGLIKSSFASCLRGNIVMVFMSLYSVLYMSSL 447
           F L+ TV  LF+ G I N L   +  Q+    KS+F   L+  ++            S L
Sbjct: 28  FPLLYTV--LFFVGLITNGLAMRIFFQIRS--KSNFIIFLKNTVI------------SDL 71

Query: 448 LPAKMFAIATINKAGWGTSGRKTIVVNFIGLIPVSVWFTI-----LLGGVIFTIYKESKR 502
           L    F    ++ A  GT   +T V     +I    +FT+      LG +    Y+++ R
Sbjct: 72  LMILTFPFKILSDAKLGTGPLRTFVCQVTSVI---FYFTMYISISFLGLITIDRYQKTTR 128

Query: 503 PFSESKQTVLIVGTLLYACYWVMLLTL---YVVLINKCGRRK 541
           PF  S    L+   +L    W  +  L    ++L N+  R K
Sbjct: 129 PFKTSNPKNLLGAKILSVVIWAFMFLLSLPNMILTNRQPRDK 170


>gi|12232483 purinergic receptor P2Y12 [Homo sapiens]
          Length = 342

 Score = 33.9 bits (76), Expect = 0.40
 Identities = 42/162 (25%), Positives = 66/162 (40%), Gaps = 27/162 (16%)

Query: 388 FFLIATVIQLFYRGKIWNILLFLLTVQLVGLIKSSFASCLRGNIVMVFMSLYSVLYMSSL 447
           F L+ TV  LF+ G I N L   +  Q+    KS+F   L+  ++            S L
Sbjct: 28  FPLLYTV--LFFVGLITNGLAMRIFFQIRS--KSNFIIFLKNTVI------------SDL 71

Query: 448 LPAKMFAIATINKAGWGTSGRKTIVVNFIGLIPVSVWFTI-----LLGGVIFTIYKESKR 502
           L    F    ++ A  GT   +T V     +I    +FT+      LG +    Y+++ R
Sbjct: 72  LMILTFPFKILSDAKLGTGPLRTFVCQVTSVI---FYFTMYISISFLGLITIDRYQKTTR 128

Query: 503 PFSESKQTVLIVGTLLYACYWVMLLTL---YVVLINKCGRRK 541
           PF  S    L+   +L    W  +  L    ++L N+  R K
Sbjct: 129 PFKTSNPKNLLGAKILSVVIWAFMFLLSLPNMILTNRQPRDK 170


>gi|224586796 G protein-coupled receptor 87 [Homo sapiens]
          Length = 358

 Score = 33.5 bits (75), Expect = 0.52
 Identities = 26/126 (20%), Positives = 57/126 (45%), Gaps = 5/126 (3%)

Query: 406 ILLFLLTVQLVGLIKSSFASCLRGNIVMVFMSLYSVLYMSSLLPAKMFAIATINKAGWGT 465
           +++F+ ++ L GL    F   +R     +F      + ++ L+    F    ++ AG+G 
Sbjct: 50  LIIFVASILLNGLAVWIFFH-IRNKTSFIFY--LKNIVVADLIMTLTFPFRIVHDAGFGP 106

Query: 466 SGRKTIVVNFIGLIPVSVWFT--ILLGGVIFTIYKESKRPFSESKQTVLIVGTLLYACYW 523
              K I+  +  ++  +  +T  + LG +    Y +  +PF +S+   +    +L  C W
Sbjct: 107 WYFKFILCRYTSVLFYANMYTSIVFLGLISIDRYLKVVKPFGDSRMYSITFTKVLSVCVW 166

Query: 524 VMLLTL 529
           V++  L
Sbjct: 167 VIMAVL 172


>gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isoform
           1 [Homo sapiens]
          Length = 790

 Score = 31.2 bits (69), Expect = 2.6
 Identities = 16/47 (34%), Positives = 28/47 (59%), Gaps = 7/47 (14%)

Query: 496 IYKESKRPFSESKQTVLIVGTLLYACYWVMLLTLYVVLINKCGRRKK 542
           + K+ + PF  S    + VG  ++AC   + L+  ++++NKCGRR K
Sbjct: 402 VEKKDETPFGVS----VAVGLAVFAC---LFLSTLLLVLNKCGRRNK 441


>gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isoform 2
           [Homo sapiens]
          Length = 796

 Score = 31.2 bits (69), Expect = 2.6
 Identities = 16/47 (34%), Positives = 28/47 (59%), Gaps = 7/47 (14%)

Query: 496 IYKESKRPFSESKQTVLIVGTLLYACYWVMLLTLYVVLINKCGRRKK 542
           + K+ + PF  S    + VG  ++AC   + L+  ++++NKCGRR K
Sbjct: 408 VEKKDETPFGVS----VAVGLAVFAC---LFLSTLLLVLNKCGRRNK 447


>gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isoform
           3 [Homo sapiens]
          Length = 760

 Score = 31.2 bits (69), Expect = 2.6
 Identities = 16/47 (34%), Positives = 28/47 (59%), Gaps = 7/47 (14%)

Query: 496 IYKESKRPFSESKQTVLIVGTLLYACYWVMLLTLYVVLINKCGRRKK 542
           + K+ + PF  S    + VG  ++AC   + L+  ++++NKCGRR K
Sbjct: 372 VEKKDETPFGVS----VAVGLAVFAC---LFLSTLLLVLNKCGRRNK 411


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.326    0.139    0.439 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,524,168
Number of Sequences: 37866
Number of extensions: 799407
Number of successful extensions: 2079
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 2064
Number of HSP's gapped (non-prelim): 12
length of query: 552
length of database: 18,247,518
effective HSP length: 107
effective length of query: 445
effective length of database: 14,195,856
effective search space: 6317155920
effective search space used: 6317155920
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.