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Search of human proteins with 13186249
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13186249 fibroblast growth factor receptor 1 isoform 9
precursor [Homo sapiens]
(785 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13186249 fibroblast growth factor receptor 1 isoform 9 precur... 1602 0.0
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu... 1584 0.0
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 1575 0.0
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 1340 0.0
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 1331 0.0
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu... 1107 0.0
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 1060 0.0
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu... 1012 0.0
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu... 1003 0.0
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 984 0.0
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu... 955 0.0
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 918 0.0
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu... 903 0.0
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 857 0.0
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 803 0.0
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 803 0.0
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 777 0.0
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu... 683 0.0
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu... 603 e-172
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur... 544 e-154
gi|13186238 fibroblast growth factor receptor 1 isoform 5 precur... 409 e-114
gi|13186241 fibroblast growth factor receptor 1 isoform 6 precur... 400 e-111
gi|11321597 kinase insert domain receptor precursor [Homo sapiens] 281 2e-75
gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [... 278 1e-74
gi|10862701 ret proto-oncogene isoform c [Homo sapiens] 273 3e-73
gi|10862703 ret proto-oncogene isoform a [Homo sapiens] 273 3e-73
gi|104294888 fms-related tyrosine kinase 4 isoform 1 precursor [... 273 4e-73
gi|103472027 fms-related tyrosine kinase 4 isoform 2 precursor [... 273 4e-73
gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like... 203 6e-52
gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [... 202 1e-51
>gi|13186249 fibroblast growth factor receptor 1 isoform 9 precursor
[Homo sapiens]
Length = 785
Score = 1602 bits (4149), Expect = 0.0
Identities = 785/785 (100%), Positives = 785/785 (100%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDD 60
MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDD
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDD 60
Query: 61 VQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSD 120
VQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSD
Sbjct: 61 VQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSD 120
Query: 121 ALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPS 180
ALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPS
Sbjct: 121 ALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPS 180
Query: 181 SGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSIN 240
SGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSIN
Sbjct: 181 SGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSIN 240
Query: 241 HTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI 300
HTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI
Sbjct: 241 HTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI 300
Query: 301 GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE 360
GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE
Sbjct: 301 GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE 360
Query: 361 ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKS 420
ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKS
Sbjct: 361 ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKS 420
Query: 421 IPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVL 480
IPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVL
Sbjct: 421 IPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVL 480
Query: 481 GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK 540
GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK
Sbjct: 481 GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK 540
Query: 541 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL 600
HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL
Sbjct: 541 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL 600
Query: 601 VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG 660
VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG
Sbjct: 601 VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG 660
Query: 661 RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKQLVEDLDRI 720
RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKQLVEDLDRI
Sbjct: 661 RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKQLVEDLDRI 720
Query: 721 VALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANG 780
VALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANG
Sbjct: 721 VALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANG 780
Query: 781 GLKRR 785
GLKRR
Sbjct: 781 GLKRR 785
>gi|105990522 fibroblast growth factor receptor 1 isoform 1
precursor [Homo sapiens]
Length = 822
Score = 1584 bits (4101), Expect = 0.0
Identities = 785/822 (95%), Positives = 785/822 (95%), Gaps = 37/822 (4%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDD 60
MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDD
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDD 60
Query: 61 VQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSD 120
VQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSD
Sbjct: 61 VQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSD 120
Query: 121 ALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPS 180
ALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPS
Sbjct: 121 ALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPS 180
Query: 181 SGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSIN 240
SGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSIN
Sbjct: 181 SGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSIN 240
Query: 241 HTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI 300
HTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI
Sbjct: 241 HTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI 300
Query: 301 GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE 360
GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE
Sbjct: 301 GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE 360
Query: 361 ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKS 420
ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKS
Sbjct: 361 ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKS 420
Query: 421 IPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVL 480
IPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVL
Sbjct: 421 IPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVL 480
Query: 481 GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK 540
GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK
Sbjct: 481 GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK 540
Query: 541 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL 600
HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL
Sbjct: 541 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL 600
Query: 601 VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG 660
VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG
Sbjct: 601 VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG 660
Query: 661 RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEEL----------- 709
RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEEL
Sbjct: 661 RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMD 720
Query: 710 --------------------------FKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSF 743
FKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSF
Sbjct: 721 KPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSF 780
Query: 744 PDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR 785
PDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR
Sbjct: 781 PDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR 822
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 1575 bits (4078), Expect = 0.0
Identities = 783/822 (95%), Positives = 783/822 (95%), Gaps = 39/822 (4%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDD 60
MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDD
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDD 60
Query: 61 VQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSD 120
VQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSD
Sbjct: 61 VQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSD 120
Query: 121 ALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPS 180
ALPSSEDDDDDDDSSSEEKETDNTKPN PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPS
Sbjct: 121 ALPSSEDDDDDDDSSSEEKETDNTKPN--PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPS 178
Query: 181 SGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSIN 240
SGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSIN
Sbjct: 179 SGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSIN 238
Query: 241 HTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI 300
HTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI
Sbjct: 239 HTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI 298
Query: 301 GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE 360
GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE
Sbjct: 299 GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE 358
Query: 361 ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKS 420
ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKS
Sbjct: 359 ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKS 418
Query: 421 IPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVL 480
IPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVL
Sbjct: 419 IPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVL 478
Query: 481 GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK 540
GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK
Sbjct: 479 GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK 538
Query: 541 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL 600
HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL
Sbjct: 539 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL 598
Query: 601 VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG 660
VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG
Sbjct: 599 VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG 658
Query: 661 RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEEL----------- 709
RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEEL
Sbjct: 659 RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMD 718
Query: 710 --------------------------FKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSF 743
FKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSF
Sbjct: 719 KPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSF 778
Query: 744 PDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR 785
PDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR
Sbjct: 779 PDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR 820
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 1340 bits (3467), Expect = 0.0
Identities = 666/703 (94%), Positives = 666/703 (94%), Gaps = 37/703 (5%)
Query: 120 DALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP 179
DALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP
Sbjct: 31 DALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP 90
Query: 180 SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI 239
SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI
Sbjct: 91 SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI 150
Query: 240 NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK 299
NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK
Sbjct: 151 NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK 210
Query: 300 IGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL 359
IGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL
Sbjct: 211 IGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL 270
Query: 360 EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAK 419
EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAK
Sbjct: 271 EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAK 330
Query: 420 SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLV 479
SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLV
Sbjct: 331 SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLV 390
Query: 480 LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIG 539
LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIG
Sbjct: 391 LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIG 450
Query: 540 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD 599
KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD
Sbjct: 451 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD 510
Query: 600 LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN 659
LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN
Sbjct: 511 LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN 570
Query: 660 GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEEL---------- 709
GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEEL
Sbjct: 571 GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRM 630
Query: 710 ---------------------------FKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPS 742
FKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPS
Sbjct: 631 DKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPS 690
Query: 743 FPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR 785
FPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR
Sbjct: 691 FPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR 733
Score = 100 bits (248), Expect = 7e-21
Identities = 82/307 (26%), Positives = 118/307 (38%), Gaps = 82/307 (26%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQ------------------------------ 30
MWSWKCLLFWAVLVTATLCTARPSPTLPEQ
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRM 60
Query: 31 --AQPWGAPVEVESFL--VHPGDLLQLRCRLRDDVQ-SINWLRDGVQLAESNR-----TR 80
A W +P ++E L V ++ +C ++ WL++G + +R R
Sbjct: 61 PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR 120
Query: 81 ITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKE 140
+ + VP+D G Y C+ + GS + ++V + P
Sbjct: 121 YATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSP----------------- 163
Query: 141 TDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLK----NGKE 196
P+ K V V+F C P P ++WLK NG +
Sbjct: 164 -------HRPILQAGLPANK------TVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK 210
Query: 197 FKPDH-------RIGGYKVRYATWSII-MDSVVPSDKGNYTCIVENEYGSINHTYQLDVV 248
PD+ + G ++ + +V D G YTC+ N G +H+ L V+
Sbjct: 211 IGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL 270
Query: 249 ERSPHRP 255
E RP
Sbjct: 271 EALEERP 277
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 1331 bits (3444), Expect = 0.0
Identities = 664/703 (94%), Positives = 664/703 (94%), Gaps = 39/703 (5%)
Query: 120 DALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP 179
DALPSSEDDDDDDDSSSEEKETDNTKPN PVAPYWTSPEKMEKKLHAVPAAKTVKFKCP
Sbjct: 31 DALPSSEDDDDDDDSSSEEKETDNTKPN--PVAPYWTSPEKMEKKLHAVPAAKTVKFKCP 88
Query: 180 SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI 239
SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI
Sbjct: 89 SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI 148
Query: 240 NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK 299
NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK
Sbjct: 149 NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK 208
Query: 300 IGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL 359
IGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL
Sbjct: 209 IGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL 268
Query: 360 EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAK 419
EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAK
Sbjct: 269 EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAK 328
Query: 420 SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLV 479
SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLV
Sbjct: 329 SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLV 388
Query: 480 LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIG 539
LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIG
Sbjct: 389 LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIG 448
Query: 540 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD 599
KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD
Sbjct: 449 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD 508
Query: 600 LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN 659
LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN
Sbjct: 509 LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN 568
Query: 660 GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEEL---------- 709
GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEEL
Sbjct: 569 GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRM 628
Query: 710 ---------------------------FKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPS 742
FKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPS
Sbjct: 629 DKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPS 688
Query: 743 FPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR 785
FPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR
Sbjct: 689 FPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR 731
Score = 100 bits (250), Expect = 4e-21
Identities = 82/305 (26%), Positives = 118/305 (38%), Gaps = 80/305 (26%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQ------------------------------ 30
MWSWKCLLFWAVLVTATLCTARPSPTLPEQ
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPV 60
Query: 31 AQPWGAPVEVESFL--VHPGDLLQLRCRLRDDVQ-SINWLRDGVQLAESNR-----TRIT 82
A W +P ++E L V ++ +C ++ WL++G + +R R
Sbjct: 61 APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYA 120
Query: 83 GEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETD 142
+ + VP+D G Y C+ + GS + ++V + P
Sbjct: 121 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSP------------------- 161
Query: 143 NTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLK----NGKEFK 198
P+ K V V+F C P P ++WLK NG +
Sbjct: 162 -----HRPILQAGLPANK------TVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIG 210
Query: 199 PDH-------RIGGYKVRYATWSII-MDSVVPSDKGNYTCIVENEYGSINHTYQLDVVER 250
PD+ + G ++ + +V D G YTC+ N G +H+ L V+E
Sbjct: 211 PDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEA 270
Query: 251 SPHRP 255
RP
Sbjct: 271 LEERP 275
>gi|221316639 fibroblast growth factor receptor 2 isoform 1
precursor [Homo sapiens]
Length = 821
Score = 1107 bits (2863), Expect = 0.0
Identities = 558/829 (67%), Positives = 648/829 (78%), Gaps = 55/829 (6%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQA--QPWGAPVEV-----ESFLVHPGDLLQL 53
M SW + V+ ATL ARPS +L E +P P + E ++ PG+ L++
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
Query: 54 RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTY 113
RC L+D I+W +DGV L +NRT + GE ++++ + P DSGLYAC S S+T Y
Sbjct: 61 RCLLKD-AAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWY 119
Query: 114 FSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKT 173
F VNV+DA+ S +D+DD D + E N K APYWT+ EKMEK+LHAVPAA T
Sbjct: 120 FMVNVTDAISSGDDEDDTDGAEDFVSENSNNKR-----APYWTNTEKMEKRLHAVPAANT 174
Query: 174 VKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVE 233
VKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGNYTC+VE
Sbjct: 175 VKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVE 234
Query: 234 NEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHI 293
NEYGSINHTY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QPHIQW+KH+
Sbjct: 235 NEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHV 294
Query: 294 EVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHS 353
E NGSK GPD LPY+++LK AGVNTTDKE+EVL++RNV+FEDAGEYTCLAGNSIG+S HS
Sbjct: 295 EKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHS 354
Query: 354 AWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMA 413
AWLTVL A + SP YLEI IYC G FLI+CMV +VI+ +MK+ TKK DF SQ A
Sbjct: 355 AWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPA 414
Query: 414 VHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSEYELPEDPRW 471
VHKL K IPLRRQVTVSA+SS+SMNS LVR +RLSS+ TPMLAGVSEYELPEDP+W
Sbjct: 415 VHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKW 474
Query: 472 ELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISE 531
E PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DATEKDLSDL+SE
Sbjct: 475 EFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSE 534
Query: 532 MEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNP 591
MEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG+EY Y+ + P
Sbjct: 535 MEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVP 594
Query: 592 EEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHI 651
EEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIADFGLARDI++I
Sbjct: 595 EEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNI 654
Query: 652 DYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEEL-- 709
DYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSPYPG+PVEEL
Sbjct: 655 DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFK 714
Query: 710 -----------------------------------FKQLVEDLDRIVALTSNQEYLDLSM 734
FKQLVEDLDRI+ LT+N+EYLDLS
Sbjct: 715 LLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQ 774
Query: 735 PLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLK 783
PL+QYSPS+PDTRSS CSSG+DSVFS +P+P EPCLP++P NG +K
Sbjct: 775 PLEQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQYPH--INGSVK 820
>gi|221316638 fibroblast growth factor receptor 2 isoform 2
precursor [Homo sapiens]
Length = 822
Score = 1060 bits (2742), Expect = 0.0
Identities = 542/832 (65%), Positives = 636/832 (76%), Gaps = 60/832 (7%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQA--QPWGAPVEV-----ESFLVHPGDLLQL 53
M SW + V+ ATL ARPS +L E +P P + E ++ PG+ L++
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
Query: 54 RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTY 113
RC L+D I+W +DGV L +NRT + GE ++++ + P DSGLYAC S S+T Y
Sbjct: 61 RCLLKD-AAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWY 119
Query: 114 FSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKT 173
F VNV+DA+ S +D+DD D + E N K APYWT+ EKMEK+LHAVPAA T
Sbjct: 120 FMVNVTDAISSGDDEDDTDGAEDFVSENSNNKR-----APYWTNTEKMEKRLHAVPAANT 174
Query: 174 VKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVE 233
VKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGNYTC+VE
Sbjct: 175 VKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVE 234
Query: 234 NEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHI 293
NEYGSINHTY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QPHIQW+KH+
Sbjct: 235 NEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHV 294
Query: 294 EVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHS 353
E NGSK GPD LPY+++LK +G+N+++ E VL L NV+ DAGEY C N IG ++ S
Sbjct: 295 EKNGSKYGPDGLPYLKVLKHSGINSSNAE--VLALFNVTEADAGEYICKVSNYIGQANQS 352
Query: 354 AWLTVL---EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHS 410
AWLTVL +A + SP YLEI IYC G FLI+CMV +VI+ +MK+ TKK DF S
Sbjct: 353 AWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSS 412
Query: 411 QMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSEYELPED 468
Q AVHKL K IPLRRQVTVSA+SS+SMNS LVR +RLSS+ TPMLAGVSEYELPED
Sbjct: 413 QPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPED 472
Query: 469 PRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDL 528
P+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DATEKDLSDL
Sbjct: 473 PKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDL 532
Query: 529 ISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPS 588
+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG+EY Y+ +
Sbjct: 533 VSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDIN 592
Query: 589 HNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDI 648
PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIADFGLARDI
Sbjct: 593 RVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI 652
Query: 649 HHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEE 708
++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSPYPG+PVEE
Sbjct: 653 NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEE 712
Query: 709 L-------------------------------------FKQLVEDLDRIVALTSNQEYLD 731
L FKQLVEDLDRI+ LT+N+EYLD
Sbjct: 713 LFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLD 772
Query: 732 LSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLK 783
LS PL+QYSPS+PDTRSS CSSG+DSVFS +P+P EPCLP++P NG +K
Sbjct: 773 LSQPLEQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQYPH--INGSVK 821
>gi|222144237 fibroblast growth factor receptor 2 isoform 6
precursor [Homo sapiens]
Length = 706
Score = 1012 bits (2616), Expect = 0.0
Identities = 498/671 (74%), Positives = 562/671 (83%), Gaps = 42/671 (6%)
Query: 152 APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYA 211
APYWT+ EKMEK+LHAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR
Sbjct: 38 APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ 97
Query: 212 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS 271
WS+IM+SVVPSDKGNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPAN + +G
Sbjct: 98 HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 157
Query: 272 NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 331
+VEF+CKVYSD QPHIQW+KH+E NGSK GPD LPY+++LK AGVNTTDKE+EVL++RNV
Sbjct: 158 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNV 217
Query: 332 SFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMV 391
+FEDAGEYTCLAGNSIG+S HSAWLTVL A + SP YLEI IYC G FLI+CMV
Sbjct: 218 TFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMV 277
Query: 392 GSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLS 450
+VI+ +MK+ TKK DF SQ AVHKL K IPLRRQVTVSA+SS+SMNS LVR +RLS
Sbjct: 278 VTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLS 337
Query: 451 SSG-TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT 509
S+ TPMLAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP
Sbjct: 338 STADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAV 397
Query: 510 KVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 569
VAVKMLK DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL
Sbjct: 398 TVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 457
Query: 570 REYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV 629
REYL+ARRPPG+EY Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNV
Sbjct: 458 REYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNV 517
Query: 630 LVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVL 689
LVTE+NVMKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL
Sbjct: 518 LVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL 577
Query: 690 LWEIFTLGGSPYPGVPVEEL-------------------------------------FKQ 712
+WEIFTLGGSPYPG+PVEEL FKQ
Sbjct: 578 MWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQ 637
Query: 713 LVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPR 772
LVEDLDRI+ LT+N+EYLDLS PL+QYSPS+PDTRSS CSSG+DSVFS +P+P EPCLP+
Sbjct: 638 LVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQ 696
Query: 773 HPAQLANGGLK 783
+P NG +K
Sbjct: 697 YPH--INGSVK 705
Score = 52.0 bits (123), Expect = 2e-06
Identities = 64/277 (23%), Positives = 105/277 (37%), Gaps = 61/277 (22%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQA--QPWGAP-------VEVESFLVHPGDLL 51
M SW + V+ ATL ARPS +L E +P GAP +E V + +
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60
Query: 52 QLRCRLRDD-VQSINWLRDGVQLAESNRTRITGEEVE-------VQDSVPADSGLYACVT 103
+ RC + + ++ WL++G + + +R I G +V ++ VP+D G Y CV
Sbjct: 61 KFRCPAGGNPMPTMRWLKNGKEFKQEHR--IGGYKVRNQHWSLIMESVVPSDKGNYTCVV 118
Query: 104 SSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEK 163
+ GS + ++V + P +P P S
Sbjct: 119 ENEYGSINHTYHLDVVERSPH--------------------RPILQAGLPANAS------ 152
Query: 164 KLHAVPAAKTVKFKCPSSGTPNPTLRWL----KNGKEFKPDH-------RIGGYKVRYAT 212
V+F C P ++W+ KNG ++ PD + G
Sbjct: 153 ----TVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKE 208
Query: 213 WSII-MDSVVPSDKGNYTCIVENEYGSINHTYQLDVV 248
++ + +V D G YTC+ N G H+ L V+
Sbjct: 209 IEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL 245
>gi|222144241 fibroblast growth factor receptor 2 isoform 8
precursor [Homo sapiens]
Length = 704
Score = 1003 bits (2594), Expect = 0.0
Identities = 496/671 (73%), Positives = 560/671 (83%), Gaps = 44/671 (6%)
Query: 152 APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYA 211
APYWT+ EKMEK+LHAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR
Sbjct: 38 APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ 97
Query: 212 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS 271
WS+IM+SVVPSDKGNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPAN + +G
Sbjct: 98 HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 157
Query: 272 NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 331
+VEF+CKVYSD QPHIQW+KH+E NGSK GPD LPY+++LK AGVNTTDKE+EVL++RNV
Sbjct: 158 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNV 217
Query: 332 SFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMV 391
+FEDAGEYTCLAGNSIG+S HSAWLTVL A + SP YLEI IYC G FLI+CMV
Sbjct: 218 TFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMV 277
Query: 392 GSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLS 450
+VI+ +MK+ TKK DF SQ AVHKL K IPLRRQV SA+SS+SMNS LVR +RLS
Sbjct: 278 VTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQV--SAESSSSMNSNTPLVRITTRLS 335
Query: 451 SSG-TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT 509
S+ TPMLAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP
Sbjct: 336 STADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAV 395
Query: 510 KVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 569
VAVKMLK DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL
Sbjct: 396 TVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 455
Query: 570 REYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV 629
REYL+ARRPPG+EY Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNV
Sbjct: 456 REYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNV 515
Query: 630 LVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVL 689
LVTE+NVMKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL
Sbjct: 516 LVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL 575
Query: 690 LWEIFTLGGSPYPGVPVEEL-------------------------------------FKQ 712
+WEIFTLGGSPYPG+PVEEL FKQ
Sbjct: 576 MWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQ 635
Query: 713 LVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPR 772
LVEDLDRI+ LT+N+EYLDLS PL+QYSPS+PDTRSS CSSG+DSVFS +P+P EPCLP+
Sbjct: 636 LVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQ 694
Query: 773 HPAQLANGGLK 783
+P NG +K
Sbjct: 695 YPH--INGSVK 703
Score = 52.0 bits (123), Expect = 2e-06
Identities = 64/277 (23%), Positives = 105/277 (37%), Gaps = 61/277 (22%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQA--QPWGAP-------VEVESFLVHPGDLL 51
M SW + V+ ATL ARPS +L E +P GAP +E V + +
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60
Query: 52 QLRCRLRDD-VQSINWLRDGVQLAESNRTRITGEEVE-------VQDSVPADSGLYACVT 103
+ RC + + ++ WL++G + + +R I G +V ++ VP+D G Y CV
Sbjct: 61 KFRCPAGGNPMPTMRWLKNGKEFKQEHR--IGGYKVRNQHWSLIMESVVPSDKGNYTCVV 118
Query: 104 SSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEK 163
+ GS + ++V + P +P P S
Sbjct: 119 ENEYGSINHTYHLDVVERSPH--------------------RPILQAGLPANAS------ 152
Query: 164 KLHAVPAAKTVKFKCPSSGTPNPTLRWL----KNGKEFKPDH-------RIGGYKVRYAT 212
V+F C P ++W+ KNG ++ PD + G
Sbjct: 153 ----TVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKE 208
Query: 213 WSII-MDSVVPSDKGNYTCIVENEYGSINHTYQLDVV 248
++ + +V D G YTC+ N G H+ L V+
Sbjct: 209 IEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL 245
>gi|222144231 fibroblast growth factor receptor 2 isoform 3
precursor [Homo sapiens]
Length = 769
Score = 984 bits (2543), Expect = 0.0
Identities = 503/776 (64%), Positives = 589/776 (75%), Gaps = 57/776 (7%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQA--QPWGAPVEV-----ESFLVHPGDLLQL 53
M SW + V+ ATL ARPS +L E +P P + E ++ PG+ L++
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
Query: 54 RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTY 113
RC L+D I+W +DGV L +NRT + GE ++++ + P DSGLYAC S S+T Y
Sbjct: 61 RCLLKD-AAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWY 119
Query: 114 FSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKT 173
F VNV+DA+ S +D+DD D + E N K APYWT+ EKMEK+LHAVPAA T
Sbjct: 120 FMVNVTDAISSGDDEDDTDGAEDFVSENSNNKR-----APYWTNTEKMEKRLHAVPAANT 174
Query: 174 VKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVE 233
VKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGNYTC+VE
Sbjct: 175 VKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVE 234
Query: 234 NEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHI 293
NEYGSINHTY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QPHIQW+KH+
Sbjct: 235 NEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHV 294
Query: 294 EVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHS 353
E NGSK GPD LPY+++LK +G+N+++ E VL L NV+ DAGEY C N IG ++ S
Sbjct: 295 EKNGSKYGPDGLPYLKVLKHSGINSSNAE--VLALFNVTEADAGEYICKVSNYIGQANQS 352
Query: 354 AWLTVL---EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHS 410
AWLTVL +A + SP YLEI IYC G FLI+CMV +VI+ +MK+ TKK DF S
Sbjct: 353 AWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSS 412
Query: 411 QMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSEYELPED 468
Q AVHKL K IPLRRQVTVSA+SS+SMNS LVR +RLSS+ TPMLAGVSEYELPED
Sbjct: 413 QPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPED 472
Query: 469 PRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDL 528
P+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DATEKDLSDL
Sbjct: 473 PKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDL 532
Query: 529 ISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPS 588
+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG+EY Y+ +
Sbjct: 533 VSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDIN 592
Query: 589 HNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDI 648
PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIADFGLARDI
Sbjct: 593 RVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI 652
Query: 649 HHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEE 708
++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSPYPG+PVEE
Sbjct: 653 NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEE 712
Query: 709 L-------------------------------------FKQLVEDLDRIVALTSNQ 727
L FKQLVEDLDRI+ LT+N+
Sbjct: 713 LFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 768
>gi|222144235 fibroblast growth factor receptor 2 isoform 5
precursor [Homo sapiens]
Length = 707
Score = 955 bits (2468), Expect = 0.0
Identities = 476/675 (70%), Positives = 541/675 (80%), Gaps = 44/675 (6%)
Query: 106 PSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKL 165
PS S ++ DA+ S +D+DD D + E N K APYWT+ EKMEK+L
Sbjct: 23 PSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSNNKR-----APYWTNTEKMEKRL 77
Query: 166 HAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK 225
HAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDK
Sbjct: 78 HAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDK 137
Query: 226 GNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQP 285
GNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QP
Sbjct: 138 GNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQP 197
Query: 286 HIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGN 345
HIQW+KH+E NGSK GPD LPY+++LK AGVNTTDKE+EVL++RNV+FEDAGEYTCLAGN
Sbjct: 198 HIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGN 257
Query: 346 SIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKK 405
SIG+S HSAWLTVL A + SP YLEI IYC G FLI+CMV +VI+ +MK+ TKK
Sbjct: 258 SIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKK 317
Query: 406 SDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSEY 463
DF SQ AVHKL K IPLRRQVTVSA+SS+SMNS LVR +RLSS+ TPMLAGVSEY
Sbjct: 318 PDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEY 377
Query: 464 ELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEK 523
ELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DATEK
Sbjct: 378 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 437
Query: 524 DLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEY 583
DLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG+EY
Sbjct: 438 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY 497
Query: 584 CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFG 643
Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIADFG
Sbjct: 498 SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 557
Query: 644 LARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPG 703
LARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSPYPG
Sbjct: 558 LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 617
Query: 704 VPVEEL-------------------------------------FKQLVEDLDRIVALTSN 726
+PVEEL FKQLVEDLDRI+ LT+N
Sbjct: 618 IPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTN 677
Query: 727 QEYLDLSMPLDQYSP 741
+E +S +D + P
Sbjct: 678 EEEKKVSGAVDCHKP 692
Score = 38.1 bits (87), Expect = 0.032
Identities = 63/303 (20%), Positives = 105/303 (34%), Gaps = 87/303 (28%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPE------------------------------- 29
M SW + V+ ATL ARPS +L E
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
Query: 30 --QAQPWGAPVEVESFL--VHPGDLLQLRCRLRDD-VQSINWLRDGVQLAESNRTRITGE 84
+A W ++E L V + ++ RC + + ++ WL++G + + +R I G
Sbjct: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR--IGGY 118
Query: 85 EVE-------VQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSE 137
+V ++ VP+D G Y CV + GS + ++V + P
Sbjct: 119 KVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPH------------- 165
Query: 138 EKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWL----KN 193
+P P S V+F C P ++W+ KN
Sbjct: 166 -------RPILQAGLPANAS----------TVVGGDVEFVCKVYSDAQPHIQWIKHVEKN 208
Query: 194 GKEFKPDH-------RIGGYKVRYATWSII-MDSVVPSDKGNYTCIVENEYGSINHTYQL 245
G ++ PD + G ++ + +V D G YTC+ N G H+ L
Sbjct: 209 GSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWL 268
Query: 246 DVV 248
V+
Sbjct: 269 TVL 271
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 918 bits (2372), Expect = 0.0
Identities = 473/776 (60%), Positives = 569/776 (73%), Gaps = 56/776 (7%)
Query: 33 PWGAPVEVESFLVHPGDLLQLRCRLRDD--VQSINWLRDGVQLAESNRTRITGEEVEVQD 90
P P + E + GD ++L C + W++DG L S R + + ++V +
Sbjct: 39 PGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLN 98
Query: 91 SVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMP 150
+ DSG Y+C + +FSV V+DA S +D+D +D++ +T
Sbjct: 99 ASHEDSGAYSC-RQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG-------- 149
Query: 151 VAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRY 210
APYWT PE+M+KKL AVPAA TV+F+CP++G P P++ WLKNG+EF+ +HRIGG K+R+
Sbjct: 150 -APYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRH 208
Query: 211 ATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALG 270
WS++M+SVVPSD+GNYTC+VEN++GSI TY LDV+ERSPHRPILQAGLPAN+T LG
Sbjct: 209 QQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLG 268
Query: 271 SNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRN 330
S+VEF CKVYSD QPHIQWLKH+EVNGSK+GPD PYV +LKTAG NTTDKE+EVL L N
Sbjct: 269 SDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHN 328
Query: 331 VSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEER-PAVMTSPLYLEIIIYCTGAFLISC 389
V+FEDAGEYTCLAGNSIG SHHSAWL VL A EE A +Y I+ Y G FL
Sbjct: 329 VTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFIL 388
Query: 390 MVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRL 449
+V +V + +++S KK VHK+++ PL+RQV S +S+ASM+S LVR +RL
Sbjct: 389 VVAAVTLCRLRSPPKKG--LGSPTVHKISR-FPLKRQV--SLESNASMSSNTPLVRIARL 443
Query: 450 SSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT 509
SS P LA VSE ELP DP+WEL R RL LGKPLGEGCFGQVV+AEAIG+DKD+ +
Sbjct: 444 SSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPV 503
Query: 510 KVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 569
VAVKMLK DAT+KDLSDL+SEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+KGNL
Sbjct: 504 TVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNL 563
Query: 570 REYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV 629
RE+L+ARRPPGL+Y ++ PEEQL+ KDLVSCAYQVARGMEYLAS+KCIHRDLAARNV
Sbjct: 564 REFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNV 623
Query: 630 LVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVL 689
LVTEDNVMKIADFGLARD+H++DYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL
Sbjct: 624 LVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL 683
Query: 690 LWEIFTLGGSPYPGVPVEEL-------------------------------------FKQ 712
LWEIFTLGGSPYPG+PVEEL FKQ
Sbjct: 684 LWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQ 743
Query: 713 LVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEP 768
LVEDLDR++ +TS EYLDLS P +QYSP DT SS+ SSG+DSVF+H+ LP P
Sbjct: 744 LVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSS-SSGDDSVFAHDLLPPAP 798
>gi|222144244 fibroblast growth factor receptor 2 isoform 9
precursor [Homo sapiens]
Length = 680
Score = 903 bits (2333), Expect = 0.0
Identities = 456/664 (68%), Positives = 522/664 (78%), Gaps = 49/664 (7%)
Query: 106 PSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKL 165
PS S ++ DA+ S +D+DD D + E N K APYWT+ EKMEK+L
Sbjct: 23 PSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSNNKR-----APYWTNTEKMEKRL 77
Query: 166 HAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK 225
HAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDK
Sbjct: 78 HAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDK 137
Query: 226 GNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQP 285
GNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QP
Sbjct: 138 GNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQP 197
Query: 286 HIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGN 345
HIQW+KH+E NGSK GPD LPY+++LK +G+N+++ E VL L NV+ DAGEY C N
Sbjct: 198 HIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAE--VLALFNVTEADAGEYICKVSN 255
Query: 346 SIGLSHHSAWLTVL---EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSG 402
IG ++ SAWLTVL +A + SP YLEI IYC G FLI+CMV +VI+ +MK+
Sbjct: 256 YIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNT 315
Query: 403 TKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGV 460
TKK DF SQ AVHKL K IPLRRQVTVSA+SS+SMNS LVR +RLSS+ TPMLAGV
Sbjct: 316 TKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGV 375
Query: 461 SEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDA 520
SEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DA
Sbjct: 376 SEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDA 435
Query: 521 TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPG 580
TEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG
Sbjct: 436 TEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPG 495
Query: 581 LEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIA 640
+EY Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIA
Sbjct: 496 MEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIA 555
Query: 641 DFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSP 700
DFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSP
Sbjct: 556 DFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSP 615
Query: 701 YPGVPVEEL-------------------------------------FKQLVEDLDRIVAL 723
YPG+PVEEL FKQLVEDLDRI+ L
Sbjct: 616 YPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTL 675
Query: 724 TSNQ 727
T+N+
Sbjct: 676 TTNE 679
Score = 38.5 bits (88), Expect = 0.024
Identities = 64/304 (21%), Positives = 106/304 (34%), Gaps = 87/304 (28%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPE------------------------------- 29
M SW + V+ ATL ARPS +L E
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
Query: 30 --QAQPWGAPVEVESFL--VHPGDLLQLRCRLRDD-VQSINWLRDGVQLAESNRTRITGE 84
+A W ++E L V + ++ RC + + ++ WL++G + + +R I G
Sbjct: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR--IGGY 118
Query: 85 EVE-------VQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSE 137
+V ++ VP+D G Y CV + GS + ++V + P
Sbjct: 119 KVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPH------------- 165
Query: 138 EKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWL----KN 193
+P P S V+F C P ++W+ KN
Sbjct: 166 -------RPILQAGLPANAS----------TVVGGDVEFVCKVYSDAQPHIQWIKHVEKN 208
Query: 194 GKEFKPDH-------RIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLD 246
G ++ PD + G A + + +V +D G Y C V N G N + L
Sbjct: 209 GSKYGPDGLPYLKVLKHSGINSSNAE-VLALFNVTEADAGEYICKVSNYIGQANQSAWLT 267
Query: 247 VVER 250
V+ +
Sbjct: 268 VLPK 271
>gi|254028242 fibroblast growth factor receptor 3 isoform 3
precursor [Homo sapiens]
Length = 808
Score = 857 bits (2215), Expect = 0.0
Identities = 450/779 (57%), Positives = 553/779 (70%), Gaps = 60/779 (7%)
Query: 33 PWGAPVEVESFLVHPGDLLQLRCRLRDD--VQSINWLRDGVQLAESNRTRITGEEVEVQD 90
P P + E + GD ++L C + W++DG L S R + + ++V +
Sbjct: 39 PGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLN 98
Query: 91 SVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMP 150
+ DSG Y+C + +FSV V+DA S +D+D +D++ +T
Sbjct: 99 ASHEDSGAYSC-RQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG-------- 149
Query: 151 VAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRY 210
APYWT PE+M+KKL AVPAA TV+F+CP++G P P++ WLKNG+EF+ +HRIGG K+R+
Sbjct: 150 -APYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRH 208
Query: 211 ATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALG 270
WS++M+SVVPSD+GNYTC+VEN++GSI TY LDV+ERSPHRPILQAGLPAN+T LG
Sbjct: 209 QQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLG 268
Query: 271 SNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRN 330
S+VEF CKVYSD QPHIQWLKH+EVNGSK+GPD PYV +LK+ + + ++ L L N
Sbjct: 269 SDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVR-LRLAN 327
Query: 331 VSFEDAGEYTCLAGNSIGLSHHSAWLTVL--EALEER--PAVMTSPLYLEIIIYCTGAFL 386
VS D GEY C A N IG++ + WL+V A EE A +Y I+ Y G FL
Sbjct: 328 VSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEEELVEADEAGSVYAGILSYGVGFFL 387
Query: 387 ISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRP 446
+V +V + +++S KK VHK+++ PL+RQV S +S+ASM+S LVR
Sbjct: 388 FILVVAAVTLCRLRSPPKKG--LGSPTVHKISR-FPLKRQV--SLESNASMSSNTPLVRI 442
Query: 447 SRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPN 506
+RLSS P LA VSE ELP DP+WEL R RL LGKPLGEGCFGQVV+AEAIG+DKD+
Sbjct: 443 ARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAA 502
Query: 507 RVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 566
+ VAVKMLK DAT+KDLSDL+SEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+K
Sbjct: 503 KPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAK 562
Query: 567 GNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAA 626
GNLRE+L+ARRPPGL+Y ++ PEEQL+ KDLVSCAYQVARGMEYLAS+KCIHRDLAA
Sbjct: 563 GNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAA 622
Query: 627 RNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSF 686
RNVLVTEDNVMKIADFGLARD+H++DYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSF
Sbjct: 623 RNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 682
Query: 687 GVLLWEIFTLGGSPYPGVPVEEL------------------------------------- 709
GVLLWEIFTLGGSPYPG+PVEEL
Sbjct: 683 GVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPT 742
Query: 710 FKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEP 768
FKQLVEDLDR++ +TS EYLDLS P +QYSP DT SS+ SSG+DSVF+H+ LP P
Sbjct: 743 FKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSS-SSGDDSVFAHDLLPPAP 800
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 803 bits (2075), Expect = 0.0
Identities = 425/743 (57%), Positives = 529/743 (71%), Gaps = 61/743 (8%)
Query: 65 NWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPS 124
+W ++G +LA + R R +E+ +P D+G Y C+ S ++ D+L S
Sbjct: 65 HWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARG-SMIVLQNLTLITGDSLTS 123
Query: 125 SEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTP 184
S +DD+D S + ++ P + APYWT P++MEKKLHAVPA TVKF+CP++G P
Sbjct: 124 S--NDDEDPKSHRDPSNRHSYPQQ---APYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNP 178
Query: 185 NPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQ 244
PT+RWLK+G+ F ++RIGG ++R+ WS++M+SVVPSD+G YTC+VEN GSI + Y
Sbjct: 179 TPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYL 238
Query: 245 LDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDN 304
LDV+ERSPHRPILQAGLPAN T +GS+VE +CKVYSD QPHIQWLKHI +NGS G D
Sbjct: 239 LDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADG 298
Query: 305 LPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEE 364
PYVQ+LKTA +N++ E+EVL+LRNVS EDAGEYTCLAGNSIGLS+ SAWLTVL EE
Sbjct: 299 FPYVQVLKTADINSS--EVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLP--EE 354
Query: 365 RP---AVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQ--MAVHKLAK 419
P A Y +II+Y +G+ ++ ++ +Y+ G H + V KL++
Sbjct: 355 DPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYR---GQALHGRHPRPPATVQKLSR 411
Query: 420 SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLV 479
PL RQ ++ + SS +S LVR RLSSSG +LAG+ +LP DP WE PRDRLV
Sbjct: 412 -FPLARQFSLESGSSGKSSSS--LVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLV 468
Query: 480 LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIG 539
LGKPLGEGCFGQVV AEA G+D +P++ + VAVKMLK +A++KDL+DL+SEME+MK+IG
Sbjct: 469 LGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIG 528
Query: 540 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD 599
+HKNIINLLG CTQ+GPLYVIVE A+KGNLRE+L+ARRPPG + + + E LS
Sbjct: 529 RHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPV 588
Query: 600 LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN 659
LVSCAYQVARGM+YL S+KCIHRDLAARNVLVTEDNVMKIADFGLAR +HHIDYYKKT+N
Sbjct: 589 LVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSN 648
Query: 660 GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEEL---------- 709
GRLPVKWMAPEALFDR+YTHQSDVWSFG+LLWEIFTLGGSPYPG+PVEEL
Sbjct: 649 GRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRM 708
Query: 710 ---------------------------FKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPS 742
FKQLVE LD+++ L ++EYLDL + YSPS
Sbjct: 709 DRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPYSPS 767
Query: 743 FPDTRSSTCSSGEDSVFSHEPLP 765
D SSTCSS DSVFSH+PLP
Sbjct: 768 GGDA-SSTCSS-SDSVFSHDPLP 788
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 803 bits (2075), Expect = 0.0
Identities = 425/743 (57%), Positives = 529/743 (71%), Gaps = 61/743 (8%)
Query: 65 NWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPS 124
+W ++G +LA + R R +E+ +P D+G Y C+ S ++ D+L S
Sbjct: 65 HWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARG-SMIVLQNLTLITGDSLTS 123
Query: 125 SEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTP 184
S +DD+D S + ++ P + APYWT P++MEKKLHAVPA TVKF+CP++G P
Sbjct: 124 S--NDDEDPKSHRDPSNRHSYPQQ---APYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNP 178
Query: 185 NPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQ 244
PT+RWLK+G+ F ++RIGG ++R+ WS++M+SVVPSD+G YTC+VEN GSI + Y
Sbjct: 179 TPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYL 238
Query: 245 LDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDN 304
LDV+ERSPHRPILQAGLPAN T +GS+VE +CKVYSD QPHIQWLKHI +NGS G D
Sbjct: 239 LDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADG 298
Query: 305 LPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEE 364
PYVQ+LKTA +N++ E+EVL+LRNVS EDAGEYTCLAGNSIGLS+ SAWLTVL EE
Sbjct: 299 FPYVQVLKTADINSS--EVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLP--EE 354
Query: 365 RP---AVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQ--MAVHKLAK 419
P A Y +II+Y +G+ ++ ++ +Y+ G H + V KL++
Sbjct: 355 DPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYR---GQALHGRHPRPPATVQKLSR 411
Query: 420 SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLV 479
PL RQ ++ + SS +S LVR RLSSSG +LAG+ +LP DP WE PRDRLV
Sbjct: 412 -FPLARQFSLESGSSGKSSSS--LVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLV 468
Query: 480 LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIG 539
LGKPLGEGCFGQVV AEA G+D +P++ + VAVKMLK +A++KDL+DL+SEME+MK+IG
Sbjct: 469 LGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIG 528
Query: 540 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD 599
+HKNIINLLG CTQ+GPLYVIVE A+KGNLRE+L+ARRPPG + + + E LS
Sbjct: 529 RHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPV 588
Query: 600 LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN 659
LVSCAYQVARGM+YL S+KCIHRDLAARNVLVTEDNVMKIADFGLAR +HHIDYYKKT+N
Sbjct: 589 LVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSN 648
Query: 660 GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEEL---------- 709
GRLPVKWMAPEALFDR+YTHQSDVWSFG+LLWEIFTLGGSPYPG+PVEEL
Sbjct: 649 GRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRM 708
Query: 710 ---------------------------FKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPS 742
FKQLVE LD+++ L ++EYLDL + YSPS
Sbjct: 709 DRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPYSPS 767
Query: 743 FPDTRSSTCSSGEDSVFSHEPLP 765
D SSTCSS DSVFSH+PLP
Sbjct: 768 GGDA-SSTCSS-SDSVFSHDPLP 788
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 777 bits (2006), Expect = 0.0
Identities = 412/738 (55%), Positives = 504/738 (68%), Gaps = 91/738 (12%)
Query: 65 NWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPS 124
+W ++G +LA + R R +E+ +P D+G Y C+ S ++ D+L S
Sbjct: 65 HWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARG-SMIVLQNLTLITGDSLTS 123
Query: 125 SEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTP 184
S +DD+D S + ++ P + APYWT P++MEKKLHAVPA TVKF+CP++G P
Sbjct: 124 S--NDDEDPKSHRDPSNRHSYPQQ---APYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNP 178
Query: 185 NPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQ 244
PT+RWLK+G+ F ++RIGG ++R+ WS++M+SVVPSD+G YTC+VEN GSI + Y
Sbjct: 179 TPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYL 238
Query: 245 LDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDN 304
LDV+ERSPHRPILQAGLPAN T +GS+VE +CKVYSD QPHIQWLKHI +NGS G D
Sbjct: 239 LDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADG 298
Query: 305 LPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEE 364
PYVQ+LKTA +N++ E+EVL+LRNVS EDAGEYTCLAGNSIGLS+ SAWLTVL
Sbjct: 299 FPYVQVLKTADINSS--EVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPGTGR 356
Query: 365 RPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLR 424
P + L +G KS
Sbjct: 357 IPHLTCDSL-------------------------TPAGRTKSP----------------- 374
Query: 425 RQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPL 484
+ S +S +S S LVR RLSSSG +LAG+ +LP DP WE PRDRLVLGKPL
Sbjct: 375 -TLQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPL 433
Query: 485 GEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNI 544
GEGCFGQVV AEA G+D +P++ + VAVKMLK +A++KDL+DL+SEME+MK+IG+HKNI
Sbjct: 434 GEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNI 493
Query: 545 INLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCA 604
INLLG CTQ+GPLYVIVE A+KGNLRE+L+ARRPPG + + + E LS LVSCA
Sbjct: 494 INLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCA 553
Query: 605 YQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPV 664
YQVARGM+YL S+KCIHRDLAARNVLVTEDNVMKIADFGLAR +HHIDYYKKT+NGRLPV
Sbjct: 554 YQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPV 613
Query: 665 KWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEEL--------------- 709
KWMAPEALFDR+YTHQSDVWSFG+LLWEIFTLGGSPYPG+PVEEL
Sbjct: 614 KWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPH 673
Query: 710 ----------------------FKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTR 747
FKQLVE LD+++ L ++EYLDL + YSPS D
Sbjct: 674 CPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPYSPSGGDA- 731
Query: 748 SSTCSSGEDSVFSHEPLP 765
SSTCSS DSVFSH+PLP
Sbjct: 732 SSTCSS-SDSVFSHDPLP 748
Score = 53.1 bits (126), Expect = 1e-06
Identities = 56/234 (23%), Positives = 89/234 (38%), Gaps = 45/234 (19%)
Query: 157 SPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSII 216
S E+ E++L V + V+ C G W K G P R+ G++ R +
Sbjct: 37 SLEQQEQEL-TVALGQPVRLCC---GRAERGGHWYKEGSRLAPAGRVRGWRGR-----LE 87
Query: 217 MDSVVPSDKGNYTCIVENEYGSINH---------TYQLDVVERSPHR-PILQAGLPANK- 265
+ S +P D G Y C+ + + T D + HR P + P
Sbjct: 88 IASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAP 147
Query: 266 -------------TVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILK 312
V G+ V+F C +P P I+WLK +G +N +
Sbjct: 148 YWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLK----DGQAFHGEN-------R 196
Query: 313 TAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERP 366
G+ + ++ + +V D G YTCL N++G ++ L VLE RP
Sbjct: 197 IGGIRLRHQHWSLV-MESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRP 249
>gi|222144233 fibroblast growth factor receptor 2 isoform 4
precursor [Homo sapiens]
Length = 709
Score = 683 bits (1762), Expect = 0.0
Identities = 373/663 (56%), Positives = 447/663 (67%), Gaps = 91/663 (13%)
Query: 188 LRWLKNGKEFKPDHR---IGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQ 244
+ W K+G P++R IG Y + + P D G Y C S +
Sbjct: 70 ISWTKDGVHLGPNNRTVLIGEY--------LQIKGATPRDSGLYACTASRTVDSETWYFM 121
Query: 245 LDVVE-------------------------RSPHRPILQAGLPANKTVALGSNVEFMCKV 279
++V + R+P+ + V + V+F C
Sbjct: 122 VNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPA 181
Query: 280 YSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEY 339
+P P ++WLK NG + ++ + G ++ ++ + +V D G Y
Sbjct: 182 GGNPMPTMRWLK----NGKEFKQEH-------RIGGYKVRNQHWSLI-MESVVPSDKGNY 229
Query: 340 TCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKM 399
TC+ N G +H+ L V+ E+ + SP YLEI IYC G FLI+CMV +VI+ +M
Sbjct: 230 TCVVENEYGSINHTYHLDVVAPGREKE-ITASPDYLEIAIYCIGVFLIACMVVTVILCRM 288
Query: 400 KSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPML 457
K+ TKK DF SQ AVHKL K IPLRRQVTVSA+SS+SMNS LVR +RLSS+ TPML
Sbjct: 289 KNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPML 348
Query: 458 AGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK 517
AGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK
Sbjct: 349 AGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK 408
Query: 518 SDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARR 577
DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARR
Sbjct: 409 DDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARR 468
Query: 578 PPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVM 637
PPG+EY Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVM
Sbjct: 469 PPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVM 528
Query: 638 KIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLG 697
KIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLG
Sbjct: 529 KIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLG 588
Query: 698 GSPYPGVPVEEL-------------------------------------FKQLVEDLDRI 720
GSPYPG+PVEEL FKQLVEDLDRI
Sbjct: 589 GSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 648
Query: 721 VALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANG 780
+ LT+N+EYLDLS PL+QYSPS+PDTRSS CSSG+DSVFS +P+P EPCLP++P NG
Sbjct: 649 LTLTTNEEYLDLSQPLEQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQYPH--ING 705
Query: 781 GLK 783
+K
Sbjct: 706 SVK 708
Score = 271 bits (694), Expect = 1e-72
Identities = 138/255 (54%), Positives = 173/255 (67%), Gaps = 13/255 (5%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQA--QPWGAPVEV-----ESFLVHPGDLLQL 53
M SW + V+ ATL ARPS +L E +P P + E ++ PG+ L++
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
Query: 54 RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTY 113
RC L+D I+W +DGV L +NRT + GE ++++ + P DSGLYAC S S+T Y
Sbjct: 61 RCLLKD-AAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWY 119
Query: 114 FSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKT 173
F VNV+DA+ S +D+DD D + E N K APYWT+ EKMEK+LHAVPAA T
Sbjct: 120 FMVNVTDAISSGDDEDDTDGAEDFVSENSNNKR-----APYWTNTEKMEKRLHAVPAANT 174
Query: 174 VKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVE 233
VKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGNYTC+VE
Sbjct: 175 VKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVE 234
Query: 234 NEYGSINHTYQLDVV 248
NEYGSINHTY LDVV
Sbjct: 235 NEYGSINHTYHLDVV 249
>gi|222144239 fibroblast growth factor receptor 2 isoform 7
precursor [Homo sapiens]
Length = 705
Score = 603 bits (1556), Expect = e-172
Identities = 344/670 (51%), Positives = 420/670 (62%), Gaps = 109/670 (16%)
Query: 188 LRWLKNGKEFKPDHR---IGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQ 244
+ W K+G P++R IG Y + + P D G Y C S +
Sbjct: 70 ISWTKDGVHLGPNNRTVLIGEY--------LQIKGATPRDSGLYACTASRTVDSETWYFM 121
Query: 245 LDVVE-------------------------RSPHRPILQAGLPANKTVALGSNVEFMCKV 279
++V + R+P+ + V + V+F C
Sbjct: 122 VNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPA 181
Query: 280 YSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEY 339
+P P ++WLK NG + ++ + G ++ ++ + +V D G Y
Sbjct: 182 GGNPMPTMRWLK----NGKEFKQEH-------RIGGYKVRNQHWSLI-MESVVPSDKGNY 229
Query: 340 TCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSV----- 394
TC+ N G +H+ L V+E RP ++ + L G C V S
Sbjct: 230 TCVVENEYGSINHTYHLDVVERSPHRP-ILQAGLPANASTVVGGDVEFVCKVYSDAQPHI 288
Query: 395 --IVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSS 451
I + K+G+K +P + + VSA+SS+SMNS LVR +RLSS
Sbjct: 289 QWIKHVEKNGSKYGP-----------DGLPYLKVLKVSAESSSSMNSNTPLVRITTRLSS 337
Query: 452 SG-TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTK 510
+ TPMLAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP
Sbjct: 338 TADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVT 397
Query: 511 VAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLR 570
VAVKMLK DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLR
Sbjct: 398 VAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLR 457
Query: 571 EYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVL 630
EYL+ARRPPG+EY Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVL
Sbjct: 458 EYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVL 517
Query: 631 VTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLL 690
VTE+NVMKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+
Sbjct: 518 VTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLM 577
Query: 691 WEIFTLGGSPYPGVPVEEL-------------------------------------FKQL 713
WEIFTLGGSPYPG+PVEEL FKQL
Sbjct: 578 WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQL 637
Query: 714 VEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRH 773
VEDLDRI+ LT+N+EYLDLS PL+QYSPS+PDTRSS CSSG+DSVFS +P+P EPCLP++
Sbjct: 638 VEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQY 696
Query: 774 PAQLANGGLK 783
P NG +K
Sbjct: 697 PH--INGSVK 704
Score = 378 bits (971), Expect = e-104
Identities = 185/326 (56%), Positives = 233/326 (71%), Gaps = 13/326 (3%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQA--QPWGAPVEV-----ESFLVHPGDLLQL 53
M SW + V+ ATL ARPS +L E +P P + E ++ PG+ L++
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
Query: 54 RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTY 113
RC L+D I+W +DGV L +NRT + GE ++++ + P DSGLYAC S S+T Y
Sbjct: 61 RCLLKD-AAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWY 119
Query: 114 FSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKT 173
F VNV+DA+ S +D+DD D + E N K APYWT+ EKMEK+LHAVPAA T
Sbjct: 120 FMVNVTDAISSGDDEDDTDGAEDFVSENSNNKR-----APYWTNTEKMEKRLHAVPAANT 174
Query: 174 VKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVE 233
VKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGNYTC+VE
Sbjct: 175 VKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVE 234
Query: 234 NEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHI 293
NEYGSINHTY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QPHIQW+KH+
Sbjct: 235 NEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHV 294
Query: 294 EVNGSKIGPDNLPYVQILKTAGVNTT 319
E NGSK GPD LPY+++LK + +++
Sbjct: 295 EKNGSKYGPDGLPYLKVLKVSAESSS 320
>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
[Homo sapiens]
Length = 694
Score = 544 bits (1402), Expect = e-154
Identities = 333/705 (47%), Positives = 411/705 (58%), Gaps = 108/705 (15%)
Query: 134 SSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP--SSGTPNPTLRWL 191
+SSE T+ R P PE +++ + V+ CP G PT+ W+
Sbjct: 20 ASSESLGTEQRVVGRAAEVP---GPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTV-WV 75
Query: 192 KNGKEFKPDHRI--GGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVV- 248
K+G P R+ G +++ S D G Y+C + H + + V
Sbjct: 76 KDGTGLVPSERVLVGPQRLQVLNAS-------HEDSGAYSCRQRLTQRVLCH-FSVRVTD 127
Query: 249 ----------ERSPHRPILQAGLPA--------NKTVAL--GSNVEFMCKVYSDPQPHIQ 288
E + G P K +A+ + V F C +P P I
Sbjct: 128 APSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSIS 187
Query: 289 WLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIG 348
WLK NG + ++ + G+ ++ ++ + +V D G YTC+ N G
Sbjct: 188 WLK----NGREFRGEH-------RIGGIKLRHQQWSLV-MESVVPSDRGNYTCVVENKFG 235
Query: 349 LSHHSAWLTVLEALEERP-------AVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKS 401
+ L VLE RP A T+ L ++ +C VY
Sbjct: 236 SIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCK-------------VYSDAQ 282
Query: 402 GTKKSDFHSQMAVHKLAKS-IPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGV 460
+ H ++ K+ P + VS +S+ASM+S LVR +RLSS P LA V
Sbjct: 283 PHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTLANV 342
Query: 461 SEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDA 520
SE ELP DP+WEL R RL LGKPLGEGCFGQVV+AEAIG+DKD+ + VAVKMLK DA
Sbjct: 343 SELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDA 402
Query: 521 TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPG 580
T+KDLSDL+SEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+KGNLRE+L+ARRPPG
Sbjct: 403 TDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPG 462
Query: 581 LEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIA 640
L+Y ++ PEEQL+ KDLVSCAYQVARGMEYLAS+KCIHRDLAARNVLVTEDNVMKIA
Sbjct: 463 LDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIA 522
Query: 641 DFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSP 700
DFGLARD+H++DYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVLLWEIFTLGGSP
Sbjct: 523 DFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSP 582
Query: 701 YPGVPVEEL-------------------------------------FKQLVEDLDRIVAL 723
YPG+PVEEL FKQLVEDLDR++ +
Sbjct: 583 YPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTV 642
Query: 724 TSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEP 768
TS EYLDLS P +QYSP DT SS+ SSG+DSVF+H+ LP P
Sbjct: 643 TSTDEYLDLSAPFEQYSPGGQDTPSSS-SSGDDSVFAHDLLPPAP 686
Score = 300 bits (769), Expect = 3e-81
Identities = 145/284 (51%), Positives = 195/284 (68%), Gaps = 12/284 (4%)
Query: 33 PWGAPVEVESFLVHPGDLLQLRCRLRDD--VQSINWLRDGVQLAESNRTRITGEEVEVQD 90
P P + E + GD ++L C + W++DG L S R + + ++V +
Sbjct: 39 PGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLN 98
Query: 91 SVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMP 150
+ DSG Y+C + +FSV V+DA S +D+D +D++ +T
Sbjct: 99 ASHEDSGAYSC-RQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG-------- 149
Query: 151 VAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRY 210
APYWT PE+M+KKL AVPAA TV+F+CP++G P P++ WLKNG+EF+ +HRIGG K+R+
Sbjct: 150 -APYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRH 208
Query: 211 ATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALG 270
WS++M+SVVPSD+GNYTC+VEN++GSI TY LDV+ERSPHRPILQAGLPAN+T LG
Sbjct: 209 QQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLG 268
Query: 271 SNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTA 314
S+VEF CKVYSD QPHIQWLKH+EVNGSK+GPD PYV +LK +
Sbjct: 269 SDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVS 312
>gi|13186238 fibroblast growth factor receptor 1 isoform 5 precursor
[Homo sapiens]
Length = 302
Score = 409 bits (1050), Expect = e-114
Identities = 193/193 (100%), Positives = 193/193 (100%)
Query: 120 DALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP 179
DALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP
Sbjct: 31 DALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP 90
Query: 180 SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI 239
SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI
Sbjct: 91 SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI 150
Query: 240 NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK 299
NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK
Sbjct: 151 NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK 210
Query: 300 IGPDNLPYVQILK 312
IGPDNLPYVQILK
Sbjct: 211 IGPDNLPYVQILK 223
Score = 85.1 bits (209), Expect = 2e-16
Identities = 67/245 (27%), Positives = 94/245 (38%), Gaps = 74/245 (30%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQ------------------------------ 30
MWSWKCLLFWAVLVTATLCTARPSPTLPEQ
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRM 60
Query: 31 --AQPWGAPVEVESFL--VHPGDLLQLRCRLRDDVQ-SINWLRDGVQLAESNR-----TR 80
A W +P ++E L V ++ +C ++ WL++G + +R R
Sbjct: 61 PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR 120
Query: 81 ITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKE 140
+ + VP+D G Y C+ + GS + ++V + P
Sbjct: 121 YATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSP----------------- 163
Query: 141 TDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLK----NGKE 196
P+ K V V+F C P P ++WLK NG +
Sbjct: 164 -------HRPILQAGLPANK------TVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK 210
Query: 197 FKPDH 201
PD+
Sbjct: 211 IGPDN 215
Score = 43.1 bits (100), Expect = 0.001
Identities = 31/106 (29%), Positives = 46/106 (43%), Gaps = 18/106 (16%)
Query: 261 LPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTD 320
+PA KTV +F C P P ++WLK NG + PD+ + G
Sbjct: 79 VPAAKTV------KFKCPSSGTPNPTLRWLK----NGKEFKPDH-------RIGGYKVRY 121
Query: 321 KEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERP 366
++ + +V D G YTC+ N G +H+ L V+E RP
Sbjct: 122 ATWSII-MDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRP 166
>gi|13186241 fibroblast growth factor receptor 1 isoform 6 precursor
[Homo sapiens]
Length = 300
Score = 400 bits (1027), Expect = e-111
Identities = 191/193 (98%), Positives = 191/193 (98%), Gaps = 2/193 (1%)
Query: 120 DALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP 179
DALPSSEDDDDDDDSSSEEKETDNTKPN PVAPYWTSPEKMEKKLHAVPAAKTVKFKCP
Sbjct: 31 DALPSSEDDDDDDDSSSEEKETDNTKPN--PVAPYWTSPEKMEKKLHAVPAAKTVKFKCP 88
Query: 180 SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI 239
SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI
Sbjct: 89 SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI 148
Query: 240 NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK 299
NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK
Sbjct: 149 NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK 208
Query: 300 IGPDNLPYVQILK 312
IGPDNLPYVQILK
Sbjct: 209 IGPDNLPYVQILK 221
Score = 85.9 bits (211), Expect = 1e-16
Identities = 67/243 (27%), Positives = 94/243 (38%), Gaps = 72/243 (29%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQ------------------------------ 30
MWSWKCLLFWAVLVTATLCTARPSPTLPEQ
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPV 60
Query: 31 AQPWGAPVEVESFL--VHPGDLLQLRCRLRDDVQ-SINWLRDGVQLAESNR-----TRIT 82
A W +P ++E L V ++ +C ++ WL++G + +R R
Sbjct: 61 APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYA 120
Query: 83 GEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETD 142
+ + VP+D G Y C+ + GS + ++V + P
Sbjct: 121 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSP------------------- 161
Query: 143 NTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLK----NGKEFK 198
P+ K V V+F C P P ++WLK NG +
Sbjct: 162 -----HRPILQAGLPANK------TVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIG 210
Query: 199 PDH 201
PD+
Sbjct: 211 PDN 213
Score = 43.1 bits (100), Expect = 0.001
Identities = 31/106 (29%), Positives = 46/106 (43%), Gaps = 18/106 (16%)
Query: 261 LPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTD 320
+PA KTV +F C P P ++WLK NG + PD+ + G
Sbjct: 77 VPAAKTV------KFKCPSSGTPNPTLRWLK----NGKEFKPDH-------RIGGYKVRY 119
Query: 321 KEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERP 366
++ + +V D G YTC+ N G +H+ L V+E RP
Sbjct: 120 ATWSII-MDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRP 164
>gi|11321597 kinase insert domain receptor precursor [Homo sapiens]
Length = 1356
Score = 281 bits (718), Expect = 2e-75
Identities = 200/557 (35%), Positives = 283/557 (50%), Gaps = 123/557 (22%)
Query: 224 DKGNYTCIVENEYGSINHTY--QLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYS 281
D+G+Y C+ ++ H QL V+ER P + L N+T ++G ++E C
Sbjct: 636 DQGDYVCLAQDRKTKKRHCVVRQLTVLERVA--PTITGNLE-NQTTSIGESIEVSCTASG 692
Query: 282 DPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTC 341
+P P I W K E +++ +G+ D L +R V ED G YTC
Sbjct: 693 NPPPQIMWFKDNET--------------LVEDSGIVLKDGNRN-LTIRRVRKEDEGLYTC 737
Query: 342 LAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKS 401
A + +G + A+ ++E +E+ LEIII G +I+ ++V ++
Sbjct: 738 QACSVLGCAKVEAFF-IIEGAQEKTN-------LEIIIL-VGTAVIAMFFWLLLVIILR- 787
Query: 402 GTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVL--LVRPSRLSSSGTPMLAG 459
TV + + +G L ++ P L
Sbjct: 788 --------------------------TVKRANGGELKTGYLSIVMDPDELP--------- 812
Query: 460 VSEY--ELPEDP-RWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKML 516
+ E+ LP D +WE PRDRL LGKPLG G FGQV+ A+A G+DK R VAVKML
Sbjct: 813 LDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRT--VAVKML 870
Query: 517 KSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDG-PLYVIVEYASKGNLREYLQ- 574
K AT + L+SE++++ IG H N++NLLGACT+ G PL VIVE+ GNL YL+
Sbjct: 871 KEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRS 930
Query: 575 ------------ARRPPGLEYC---------------------------------YNPSH 589
AR G +Y
Sbjct: 931 KRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEE 990
Query: 590 NPEEQ----LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLA 645
PE+ L+ + L+ ++QVA+GME+LAS+KCIHRDLAARN+L++E NV+KI DFGLA
Sbjct: 991 APEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLA 1050
Query: 646 RDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVP 705
RDI+ Y + + RLP+KWMAPE +FDR+YT QSDVWSFGVLLWEIF+LG SPYPGV
Sbjct: 1051 RDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVK 1110
Query: 706 VEELFKQLVEDLDRIVA 722
++E F + +++ R+ A
Sbjct: 1111 IDEEFCRRLKEGTRMRA 1127
Score = 45.8 bits (107), Expect = 2e-04
Identities = 46/190 (24%), Positives = 75/190 (39%), Gaps = 9/190 (4%)
Query: 107 SGSDTTYF-SVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKL 165
SGS+ F S D + S+ +SS N+ R+ P+ ME +
Sbjct: 281 SGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLV 340
Query: 166 HAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK 225
A + V+ G P P ++W KNG + +H I V + + V D
Sbjct: 341 EAT-VGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHV------LTIMEVSERDT 393
Query: 226 GNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQP 285
GNYT I+ N ++ + +V P + ++ + + G+ C VY+ P P
Sbjct: 394 GNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPP 453
Query: 286 -HIQWLKHIE 294
HI W +E
Sbjct: 454 HHIHWYWQLE 463
Score = 37.4 bits (85), Expect = 0.054
Identities = 36/142 (25%), Positives = 55/142 (38%), Gaps = 24/142 (16%)
Query: 214 SIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQ--AGLPANKTVALGS 271
++ +D V SD+G YTC + + ++ + V E+ P + +G+ + +G
Sbjct: 291 TLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEK----PFVAFGSGMESLVEATVGE 346
Query: 272 NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 331
V K P P I+W K NG + N T K VL + V
Sbjct: 347 RVRIPAKYLGYPPPEIKWYK----NGIPLES--------------NHTIKAGHVLTIMEV 388
Query: 332 SFEDAGEYTCLAGNSIGLSHHS 353
S D G YT + N I S
Sbjct: 389 SERDTGNYTVILTNPISKEKQS 410
Score = 34.7 bits (78), Expect = 0.35
Identities = 68/329 (20%), Positives = 119/329 (36%), Gaps = 59/329 (17%)
Query: 64 INWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALP 123
I W ++G+ L ESN T G + + + D+G Y + ++P + V++ +P
Sbjct: 362 IKWYKNGIPL-ESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVP 420
Query: 124 SSEDDDD-DDDSSSEEKETDNTKPNRMPVAP-------YWTSPEKMEKKLHAVPAAKTVK 175
+ S + T T + P YW ++E++ P+
Sbjct: 421 PQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYW----QLEEECANEPS----- 471
Query: 176 FKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYA-------TWSIIMDSVVPSDKGNY 228
+ S P P W ++ ++F+ ++I K ++A T S ++ + Y
Sbjct: 472 -QAVSVTNPYPCEEW-RSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAA-NVSALY 528
Query: 229 TCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQ 288
C N+ G V R P + P + +V C ++
Sbjct: 529 KCEAVNKVGRGERVISFHVT-RGPEITLQPDMQPTEQ-----ESVSLWCTADRSTFENLT 582
Query: 289 WLKHIEVNGSKIGPDNLP-YVQILKTAGVNTTD--------------KEMEVLHLRNVSF 333
W K +GP LP +V L T D ++ ++ L+N S
Sbjct: 583 WYK--------LGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASL 634
Query: 334 EDAGEYTCLAGNSIGLSHHSA--WLTVLE 360
+D G+Y CLA + H LTVLE
Sbjct: 635 QDQGDYVCLAQDRKTKKRHCVVRQLTVLE 663
Score = 32.7 bits (73), Expect = 1.3
Identities = 15/59 (25%), Positives = 29/59 (49%), Gaps = 3/59 (5%)
Query: 172 KTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTC 230
++++ C +SG P P + W K+ + D G ++ ++ + V D+G YTC
Sbjct: 682 ESIEVSCTASGNPPPQIMWFKDNETLVED---SGIVLKDGNRNLTIRRVRKEDEGLYTC 737
>gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [Homo
sapiens]
Length = 1338
Score = 278 bits (712), Expect = 1e-74
Identities = 195/554 (35%), Positives = 275/554 (49%), Gaps = 117/554 (21%)
Query: 212 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS 271
T ++ + +V D G Y C N Y + ++ R P L L ++ TVA+ S
Sbjct: 618 TLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNL-SDHTVAISS 676
Query: 272 NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 331
+ C P+P I W K N KI + I+ G +T L + V
Sbjct: 677 STTLDCHANGVPEPQITWFK----NNHKIQQEP----GIILGPGSST-------LFIERV 721
Query: 332 SFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMV 391
+ ED G Y C A N G SA+LTV ++ + + + C A L ++
Sbjct: 722 TEEDEGVYHCKATNQKGSVESSAYLTVQGTSDKSNLEL-----ITLTCTCVAATLFWLLL 776
Query: 392 GSVIVYKMKSGTK--KSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRL 449
++ + KMK + K+D+ +++ +PL Q
Sbjct: 777 -TLFIRKMKRSSSEIKTDY---LSIIMDPDEVPLDEQCE--------------------- 811
Query: 450 SSSGTPMLAGVSEYELPEDP-RWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRV 508
LP D +WE R+RL LGK LG G FG+VV A A G+ K R
Sbjct: 812 --------------RLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRT 857
Query: 509 TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKG 567
VAVKMLK AT + L++E++++ IG H N++NLLGACT Q GPL VIVEY G
Sbjct: 858 --VAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYG 915
Query: 568 NLREYLQARRP--------------------PGLEYCYNPSHNP---------------- 591
NL YL+++R PGLE P +
Sbjct: 916 NLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDK 975
Query: 592 ---------------EEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV 636
+E ++ +DL+S ++QVARGME+L+S+KCIHRDLAARN+L++E+NV
Sbjct: 976 SLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNV 1035
Query: 637 MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTL 696
+KI DFGLARDI+ Y + + RLP+KWMAPE++FD+IY+ +SDVWS+GVLLWEIF+L
Sbjct: 1036 VKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSL 1095
Query: 697 GGSPYPGVPVEELF 710
GGSPYPGV ++E F
Sbjct: 1096 GGSPYPGVQMDEDF 1109
Score = 47.4 bits (111), Expect = 5e-05
Identities = 35/143 (24%), Positives = 59/143 (41%), Gaps = 14/143 (9%)
Query: 156 TSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYAT--W 213
T + ++ L V ++ + P+P + WLK+G RY T +
Sbjct: 335 TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEK------SARYLTRGY 388
Query: 214 SIIMDSVVPSDKGNYTCIVE----NEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL 269
S+I+ V D GNYT ++ N + ++ T ++V + + + + P L
Sbjct: 389 SLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV--SSFPDPALYPL 446
Query: 270 GSNVEFMCKVYSDPQPHIQWLKH 292
GS C Y PQP I+W H
Sbjct: 447 GSRQILTCTAYGIPQPTIKWFWH 469
Score = 40.8 bits (94), Expect = 0.005
Identities = 20/82 (24%), Positives = 38/82 (46%), Gaps = 3/82 (3%)
Query: 166 HAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK 225
H V + + C ++G P P + W KN + + + G + + ++ ++ V D+
Sbjct: 670 HTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQE---PGIILGPGSSTLFIERVTEEDE 726
Query: 226 GNYTCIVENEYGSINHTYQLDV 247
G Y C N+ GS+ + L V
Sbjct: 727 GVYHCKATNQKGSVESSAYLTV 748
Score = 35.0 bits (79), Expect = 0.27
Identities = 38/134 (28%), Positives = 59/134 (44%), Gaps = 29/134 (21%)
Query: 215 IIMDSVVPSDKGNYTCIVEN--EYGSIN---HTY-QLDVVERSPHRPILQAGLPANKTVA 268
+ +D + DKG YTC V + + S+N H Y + + + + +L+ TVA
Sbjct: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLE-------TVA 348
Query: 269 LGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHL 328
+ KV + P P + WLK D LP + K+A T L +
Sbjct: 349 GKRSYRLSMKVKAFPSPEVVWLK-----------DGLPATE--KSARYLTRGYS---LII 392
Query: 329 RNVSFEDAGEYTCL 342
++V+ EDAG YT L
Sbjct: 393 KDVTEEDAGNYTIL 406
>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
Length = 1072
Score = 273 bits (699), Expect = 3e-73
Identities = 171/411 (41%), Positives = 234/411 (56%), Gaps = 46/411 (11%)
Query: 384 AFLISCMVGSVIVYKMKSGTKKSDFHS-QMAVHKLAKSIPLRRQVTVSADSSASMNSGVL 442
+F++S ++ + ++ K S +M + A++ P VS SS +
Sbjct: 645 SFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFP------VSYSSSGAR----- 693
Query: 443 LVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDK 502
RPS S V +++ EDP+WE PR LVLGK LGEG FG+VV A A L K
Sbjct: 694 --RPSLDSMENQ---VSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL-K 747
Query: 503 DKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVE 562
+ T VAVKMLK +A+ +L DL+SE ++K + H ++I L GAC+QDGPL +IVE
Sbjct: 748 GRAGYTT-VAVKMLKENASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVE 805
Query: 563 YASKGNLREYLQARRPPGLEYCYNPS--------HNPEEQLSSKDLVSCAYQVARGMEYL 614
YA G+LR +L+ R G Y + H E L+ DL+S A+Q+++GM+YL
Sbjct: 806 YAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL 865
Query: 615 ASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFD 674
A K +HRDLAARN+LV E MKI+DFGL+RD++ D Y K + GR+PVKWMA E+LFD
Sbjct: 866 AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFD 925
Query: 675 RIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKQL------------VEDLDRIVA 722
IYT QSDVWSFGVLLWEI TLGG+PYPG+P E LF L E++ R++
Sbjct: 926 HIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLML 985
Query: 723 LTSNQE------YLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEE 767
QE + D+S L++ D S+ DS+ + L EE
Sbjct: 986 QCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEE 1036
>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
Length = 1114
Score = 273 bits (699), Expect = 3e-73
Identities = 171/411 (41%), Positives = 234/411 (56%), Gaps = 46/411 (11%)
Query: 384 AFLISCMVGSVIVYKMKSGTKKSDFHS-QMAVHKLAKSIPLRRQVTVSADSSASMNSGVL 442
+F++S ++ + ++ K S +M + A++ P VS SS +
Sbjct: 645 SFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFP------VSYSSSGAR----- 693
Query: 443 LVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDK 502
RPS S V +++ EDP+WE PR LVLGK LGEG FG+VV A A L K
Sbjct: 694 --RPSLDSMENQ---VSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL-K 747
Query: 503 DKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVE 562
+ T VAVKMLK +A+ +L DL+SE ++K + H ++I L GAC+QDGPL +IVE
Sbjct: 748 GRAGYTT-VAVKMLKENASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVE 805
Query: 563 YASKGNLREYLQARRPPGLEYCYNPS--------HNPEEQLSSKDLVSCAYQVARGMEYL 614
YA G+LR +L+ R G Y + H E L+ DL+S A+Q+++GM+YL
Sbjct: 806 YAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL 865
Query: 615 ASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFD 674
A K +HRDLAARN+LV E MKI+DFGL+RD++ D Y K + GR+PVKWMA E+LFD
Sbjct: 866 AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFD 925
Query: 675 RIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKQL------------VEDLDRIVA 722
IYT QSDVWSFGVLLWEI TLGG+PYPG+P E LF L E++ R++
Sbjct: 926 HIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLML 985
Query: 723 LTSNQE------YLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEE 767
QE + D+S L++ D S+ DS+ + L EE
Sbjct: 986 QCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEE 1036
>gi|104294888 fms-related tyrosine kinase 4 isoform 1 precursor [Homo
sapiens]
Length = 1363
Score = 273 bits (698), Expect = 4e-73
Identities = 193/563 (34%), Positives = 279/563 (49%), Gaps = 107/563 (19%)
Query: 209 RYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVA 268
R+AT S+ + V P +G+Y C V++ H ++ + ++ P L L + V
Sbjct: 632 RHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNL-TDLLVN 690
Query: 269 LGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHL 328
+ ++E C V P I W K + K +GV+ D + L +
Sbjct: 691 VSDSLEMQCLVAGAHAPSIVWYKDERLLEEK--------------SGVDLADSNQK-LSI 735
Query: 329 RNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLIS 388
+ V EDAG Y C N+ G + SA + V E E++ ++ +I+ TG +
Sbjct: 736 QRVREEDAGRYLCSVCNAKGCVNSSASVAV-EGSEDKGSMEI------VILVGTGVIAVF 788
Query: 389 CMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSR 448
V ++++ + + A + +G L +
Sbjct: 789 FWVLLLLIF-----------------------------CNMRRPAHADIKTGYLSI---- 815
Query: 449 LSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRV 508
+ G L EY + +WE PR+RL LG+ LG G FG+VV A A G+ K +
Sbjct: 816 IMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKG--SSC 873
Query: 509 TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQ-DGPLYVIVEYASKG 567
VAVKMLK AT + L+SE++++ IG H N++NLLGACT+ GPL VIVE+ G
Sbjct: 874 DTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYG 933
Query: 568 NLREYLQA-----------------------------RRPPGLEYCY------------- 585
NL +L+A RR PG
Sbjct: 934 NLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGAR 993
Query: 586 --NPSHNPEE----QLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKI 639
+P E+ L+ +DLV ++QVARGME+LAS+KCIHRDLAARN+L++E +V+KI
Sbjct: 994 RASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKI 1053
Query: 640 ADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGS 699
DFGLARDI+ Y + + RLP+KWMAPE++FD++YT QSDVWSFGVLLWEIF+LG S
Sbjct: 1054 CDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGAS 1113
Query: 700 PYPGVPVEELFKQLVEDLDRIVA 722
PYPGV + E F Q + D R+ A
Sbjct: 1114 PYPGVQINEEFCQRLRDGTRMRA 1136
Score = 36.2 bits (82), Expect = 0.12
Identities = 28/126 (22%), Positives = 47/126 (37%), Gaps = 11/126 (8%)
Query: 165 LHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSD 224
L A + VK + P P +W K+GK R++ ++++ V +
Sbjct: 343 LEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSG---------RHSPHALVLKEVTEAS 393
Query: 225 KGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQ 284
G YT + N + L++V P + I + + + S C Y P
Sbjct: 394 TGTYTLALWNSAAGLRRNISLELVVNVPPQ-IHEKEASSPSIYSRHSRQALTCTAYGVPL 452
Query: 285 P-HIQW 289
P IQW
Sbjct: 453 PLSIQW 458
>gi|103472027 fms-related tyrosine kinase 4 isoform 2 precursor [Homo
sapiens]
Length = 1298
Score = 273 bits (698), Expect = 4e-73
Identities = 193/563 (34%), Positives = 279/563 (49%), Gaps = 107/563 (19%)
Query: 209 RYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVA 268
R+AT S+ + V P +G+Y C V++ H ++ + ++ P L L + V
Sbjct: 632 RHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNL-TDLLVN 690
Query: 269 LGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHL 328
+ ++E C V P I W K + K +GV+ D + L +
Sbjct: 691 VSDSLEMQCLVAGAHAPSIVWYKDERLLEEK--------------SGVDLADSNQK-LSI 735
Query: 329 RNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLIS 388
+ V EDAG Y C N+ G + SA + V E E++ ++ +I+ TG +
Sbjct: 736 QRVREEDAGRYLCSVCNAKGCVNSSASVAV-EGSEDKGSMEI------VILVGTGVIAVF 788
Query: 389 CMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSR 448
V ++++ + + A + +G L +
Sbjct: 789 FWVLLLLIF-----------------------------CNMRRPAHADIKTGYLSI---- 815
Query: 449 LSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRV 508
+ G L EY + +WE PR+RL LG+ LG G FG+VV A A G+ K +
Sbjct: 816 IMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKG--SSC 873
Query: 509 TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQ-DGPLYVIVEYASKG 567
VAVKMLK AT + L+SE++++ IG H N++NLLGACT+ GPL VIVE+ G
Sbjct: 874 DTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYG 933
Query: 568 NLREYLQA-----------------------------RRPPGLEYCY------------- 585
NL +L+A RR PG
Sbjct: 934 NLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGAR 993
Query: 586 --NPSHNPEE----QLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKI 639
+P E+ L+ +DLV ++QVARGME+LAS+KCIHRDLAARN+L++E +V+KI
Sbjct: 994 RASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKI 1053
Query: 640 ADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGS 699
DFGLARDI+ Y + + RLP+KWMAPE++FD++YT QSDVWSFGVLLWEIF+LG S
Sbjct: 1054 CDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGAS 1113
Query: 700 PYPGVPVEELFKQLVEDLDRIVA 722
PYPGV + E F Q + D R+ A
Sbjct: 1114 PYPGVQINEEFCQRLRDGTRMRA 1136
Score = 36.2 bits (82), Expect = 0.12
Identities = 28/126 (22%), Positives = 47/126 (37%), Gaps = 11/126 (8%)
Query: 165 LHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSD 224
L A + VK + P P +W K+GK R++ ++++ V +
Sbjct: 343 LEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSG---------RHSPHALVLKEVTEAS 393
Query: 225 KGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQ 284
G YT + N + L++V P + I + + + S C Y P
Sbjct: 394 TGTYTLALWNSAAGLRRNISLELVVNVPPQ-IHEKEASSPSIYSRHSRQALTCTAYGVPL 452
Query: 285 P-HIQW 289
P IQW
Sbjct: 453 PLSIQW 458
>gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like
domains 1 [Homo sapiens]
Length = 1138
Score = 203 bits (516), Expect = 6e-52
Identities = 115/230 (50%), Positives = 148/230 (64%), Gaps = 8/230 (3%)
Query: 484 LGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 543
+GEG FGQV+ A I D K N A+KMLK A+E D D E+E++ +G H N
Sbjct: 845 IGEGNFGQVIRA-MIKKDGLKMN----AAIKMLKEYASENDHRDFAGELEVLCKLGHHPN 899
Query: 544 IINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSC 603
IINLLGAC G LY+ +EYA GNL ++L+ R + + H LSS+ L+
Sbjct: 900 IINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRF 959
Query: 604 AYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLP 663
A A GM+YL+ K+ IHRDLAARNVLV E+ KIADFGL+R + Y K T GRLP
Sbjct: 960 ASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRG---EEVYVKKTMGRLP 1016
Query: 664 VKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKQL 713
V+WMA E+L +YT +SDVWSFGVLLWEI +LGG+PY G+ EL+++L
Sbjct: 1017 VRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKL 1066
Score = 32.3 bits (72), Expect = 1.7
Identities = 17/37 (45%), Positives = 20/37 (54%)
Query: 82 TGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNV 118
T E EV V ADSG + C S+ G D+ F VNV
Sbjct: 407 TTAEFEVPRLVLADSGFWECRVSTSGGQDSRRFKVNV 443
>gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [Homo
sapiens]
Length = 1070
Score = 202 bits (513), Expect = 1e-51
Identities = 180/664 (27%), Positives = 296/664 (44%), Gaps = 99/664 (14%)
Query: 63 SINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGL-YACVTSSPSGSDTTYFSVNVSDA 121
++ W R+ + ++E +R + +SV G Y C++S+P+GS V V +
Sbjct: 442 TVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLEK 501
Query: 122 LPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSS 181
L +T P + ++ + K C ++
Sbjct: 502 LK-------------------------------FTPPPQPQQ---CMEFDKEATVPCSAT 527
Query: 182 GTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVEN-EYGSIN 240
G PT++W + P+ V ++ V D GNYTCI N G I
Sbjct: 528 GREKPTIKWERADGSSLPEW------VTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIR 581
Query: 241 HTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWL-KHIEVNGSK 299
QL V + P TV G C+ DP+P IQW K ++ +K
Sbjct: 582 AHVQLTVAVFITFKVE-----PERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTK 636
Query: 300 IGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL 359
+GP + I + + V+H +V+ ED+G YTC+AGNS + H A L V+
Sbjct: 637 LGPR----MHIFQNGSL--------VIH--DVAPEDSGRYTCIAGNSCNIKHTEAPLYVV 682
Query: 360 E--ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKL 417
+ EE + P Y I I VG+ + Y + + K
Sbjct: 683 DKPVPEESEGPGSPPPYKMIQT-------IGLSVGAAVAYII------AVLGLMFYCKKR 729
Query: 418 AKSIPLRRQVTVSADSSASMNSGVL--------LVRPSRLSSSGTPMLAGVSEYELPEDP 469
K+ L++Q +N G L + L+S G+ A + +
Sbjct: 730 CKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSD-- 787
Query: 470 RWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLI 529
+ PR L LG+ FG+V LA+A GL++ T V VK L+S ++ L D
Sbjct: 788 KMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAE--TLVLVKSLQSKDEQQQL-DFR 844
Query: 530 SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSH 589
E+EM + H N++ LLG C + P Y+++EY G+L+++L+ + + P
Sbjct: 845 RELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQP-- 901
Query: 590 NPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIH 649
LS+K V+ QVA GME+L++ + +H+DLAARN LV+ +K++ GL++D++
Sbjct: 902 -----LSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVY 956
Query: 650 HIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEEL 709
+ +YY +P++WM+PEA+ + ++ +SDVW+FGVL+WE+FT G P+ G +E+
Sbjct: 957 NSEYY-HFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEV 1015
Query: 710 FKQL 713
L
Sbjct: 1016 LADL 1019
Score = 53.1 bits (126), Expect = 1e-06
Identities = 60/283 (21%), Positives = 105/283 (37%), Gaps = 61/283 (21%)
Query: 63 SINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDAL 122
S+ W GV+L R G E+ + + +D+G+Y C ++ +G ++ V+ +
Sbjct: 353 SVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVA-TV 411
Query: 123 PSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSG 182
PS ++ + + KP + C +
Sbjct: 412 PSWL-------KKPQDSQLEEGKPGYL---------------------------DCLTQA 437
Query: 183 TPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHT 242
TP PT+ W +N D R +K ++ ++SV D Y C+ GSI
Sbjct: 438 TPKPTVVWYRNQMLISEDSRFEVFK----NGTLRINSVEVYDGTWYRCMSSTPAGSIEAQ 493
Query: 243 YQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGP 302
++ V+E+ P Q + + C +P I+W + +GS + P
Sbjct: 494 ARVQVLEKLKFTPPPQ----PQQCMEFDKEATVPCSATGREKPTIKWER---ADGSSL-P 545
Query: 303 DNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGN 345
+ + AG LH V+ +DAG YTC+A N
Sbjct: 546 E-----WVTDNAG---------TLHFARVTRDDAGNYTCIASN 574
Score = 52.8 bits (125), Expect = 1e-06
Identities = 79/327 (24%), Positives = 124/327 (37%), Gaps = 71/327 (21%)
Query: 45 VHPGDLLQLRCRLRDDVQ-SINWLRDGVQLAE--SNRTRITGEE-VEVQDSVPADSGLYA 100
+ P + LRC + + + W RDG L++ SN T + E + ++ + P SGLY+
Sbjct: 140 IQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYS 199
Query: 101 CVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEK 160
C S G + + +S A D+S + R+ +AP +
Sbjct: 200 CCAHSAFGQACSSQNFTLSIA----------DESFA-----------RVVLAPQDVVVAR 238
Query: 161 MEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGK-----EFKPDHRIGGYKVRYATWSI 215
E+ + F C S P P+L+WL + +P H +A S+
Sbjct: 239 YEEAM----------FHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRA--TVFANGSL 286
Query: 216 IMDSVVPSDKGNYTCIVENEYGS---INHTYQLDVVERSPHRPILQAGLPANKTVALGSN 272
++ V P + G Y CI + + G + T L +E P L + GS
Sbjct: 287 LLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP--------LFEPRVFTAGSE 338
Query: 273 VEFMCKVYSD-PQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 331
C P+P + W +H V L T G K E++ L N+
Sbjct: 339 ERVTCLPPKGLPEPSVWW-EHAGVR--------------LPTHG-RVYQKGHELV-LANI 381
Query: 332 SFEDAGEYTCLAGNSIGLSHHSAWLTV 358
+ DAG YTC A N G +TV
Sbjct: 382 AESDAGVYTCHAANLAGQRRQDVNITV 408
Score = 47.0 bits (110), Expect = 7e-05
Identities = 51/246 (20%), Positives = 87/246 (35%), Gaps = 43/246 (17%)
Query: 54 RCRLRDDVQS-----INWLRDGVQLAESNRTRITGEEVEVQ--DSVPADSGLYACVTSSP 106
R LR +V++ + WL DG + ++ R G + D + DSG + CV
Sbjct: 48 RALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ-DSGTFQCVAR-- 104
Query: 107 SGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLH 166
DD + EE + N N + + +
Sbjct: 105 -------------------------DDVTGEEARSANASFNIKWIEAGPVVLKHPASEAE 139
Query: 167 AVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKG 226
P + V +C G P PT +W ++G + V ++ + P G
Sbjct: 140 IQPQTQ-VTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEHSG 196
Query: 227 NYTCIVENEYGSI--NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQ 284
Y+C + +G + + L + + S R +L P + VA F C+ + P
Sbjct: 197 LYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPP 253
Query: 285 PHIQWL 290
P +QWL
Sbjct: 254 PSLQWL 259
Score = 36.6 bits (83), Expect = 0.093
Identities = 42/193 (21%), Positives = 66/193 (34%), Gaps = 36/193 (18%)
Query: 179 PSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGS 238
P G P P++ W G P H +V +++ ++ SD G YTC N G
Sbjct: 345 PPKGLPEPSVWWEHAGVRL-PTHG----RVYQKGHELVLANIAESDAGVYTCHAANLAGQ 399
Query: 239 INHTYQLDVVE-----RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHI 293
+ V + P L+ G P C + P+P + W +
Sbjct: 400 RRQDVNITVATVPSWLKKPQDSQLEEGKPGYLD----------CLTQATPKPTVVWYR-- 447
Query: 294 EVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHS 353
N I D+ ++ K L + +V D Y C++ G
Sbjct: 448 --NQMLISEDSR--FEVFKNG----------TLRINSVEVYDGTWYRCMSSTPAGSIEAQ 493
Query: 354 AWLTVLEALEERP 366
A + VLE L+ P
Sbjct: 494 ARVQVLEKLKFTP 506
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,267,345
Number of Sequences: 37866
Number of extensions: 1656069
Number of successful extensions: 14935
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 704
Number of HSP's successfully gapped in prelim test: 425
Number of HSP's that attempted gapping in prelim test: 7565
Number of HSP's gapped (non-prelim): 4121
length of query: 785
length of database: 18,247,518
effective HSP length: 110
effective length of query: 675
effective length of database: 14,082,258
effective search space: 9505524150
effective search space used: 9505524150
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.