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Search of human proteins with 109150427
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|109150427 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase-like 1 isoform a [Homo sapiens]
(370 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|109150427 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-l... 745 0.0
gi|109150422 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-l... 666 0.0
gi|62198232 3-hydroxy-3-methylglutaryl CoA lyase [Homo sapiens] 447 e-126
gi|106049528 pyruvate carboxylase precursor [Homo sapiens] 47 2e-05
gi|106049295 pyruvate carboxylase precursor [Homo sapiens] 47 2e-05
gi|106049292 pyruvate carboxylase precursor [Homo sapiens] 47 2e-05
gi|194272176 phospholipase D1 isoform b [Homo sapiens] 34 0.24
gi|115387102 adenylate cyclase 2 [Homo sapiens] 29 5.9
gi|72255574 zinc finger protein 451 isoform 2 [Homo sapiens] 29 5.9
gi|72255571 zinc finger protein 451 isoform 1 [Homo sapiens] 29 5.9
gi|239756254 PREDICTED: similar to tubulin, beta 5 [Homo sapiens] 29 7.7
gi|239750785 PREDICTED: similar to tubulin, beta 5 [Homo sapiens] 29 7.7
gi|19913408 DNA topoisomerase II, beta isozyme [Homo sapiens] 29 7.7
>gi|109150427 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like
1 isoform a [Homo sapiens]
Length = 370
Score = 745 bits (1923), Expect = 0.0
Identities = 370/370 (100%), Positives = 370/370 (100%)
Query: 1 MGNVPSAVKHCLSYQQLLREHLWIGDSVAGALDPAQTSLLTNLHCFQPDVSGFSVSLAGT 60
MGNVPSAVKHCLSYQQLLREHLWIGDSVAGALDPAQTSLLTNLHCFQPDVSGFSVSLAGT
Sbjct: 1 MGNVPSAVKHCLSYQQLLREHLWIGDSVAGALDPAQTSLLTNLHCFQPDVSGFSVSLAGT 60
Query: 61 VACIHWETSQLSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTS 120
VACIHWETSQLSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTS
Sbjct: 61 VACIHWETSQLSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTS 120
Query: 121 FVSSRWVPQMADHTEVMKGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAASESFS 180
FVSSRWVPQMADHTEVMKGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAASESFS
Sbjct: 121 FVSSRWVPQMADHTEVMKGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAASESFS 180
Query: 181 KKNINCSIEESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSKRLYGM 240
KKNINCSIEESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSKRLYGM
Sbjct: 181 KKNINCSIEESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSKRLYGM 240
Query: 241 GCYEISLGDTIGVGTPGSMKRMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINV 300
GCYEISLGDTIGVGTPGSMKRMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINV
Sbjct: 241 GCYEISLGDTIGVGTPGSMKRMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINV 300
Query: 301 VDSAVSGLGGCPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAVNKTTN 360
VDSAVSGLGGCPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAVNKTTN
Sbjct: 301 VDSAVSGLGGCPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAVNKTTN 360
Query: 361 SKVAQASFNA 370
SKVAQASFNA
Sbjct: 361 SKVAQASFNA 370
>gi|109150422 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like
1 isoform b [Homo sapiens]
Length = 340
Score = 666 bits (1718), Expect = 0.0
Identities = 340/370 (91%), Positives = 340/370 (91%), Gaps = 30/370 (8%)
Query: 1 MGNVPSAVKHCLSYQQLLREHLWIGDSVAGALDPAQTSLLTNLHCFQPDVSGFSVSLAGT 60
MGNVPSAVKHCLSYQQLLREHLWIGDSVAGALDPAQ
Sbjct: 1 MGNVPSAVKHCLSYQQLLREHLWIGDSVAGALDPAQ------------------------ 36
Query: 61 VACIHWETSQLSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTS 120
ETSQLSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTS
Sbjct: 37 ------ETSQLSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTS 90
Query: 121 FVSSRWVPQMADHTEVMKGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAASESFS 180
FVSSRWVPQMADHTEVMKGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAASESFS
Sbjct: 91 FVSSRWVPQMADHTEVMKGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAASESFS 150
Query: 181 KKNINCSIEESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSKRLYGM 240
KKNINCSIEESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSKRLYGM
Sbjct: 151 KKNINCSIEESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSKRLYGM 210
Query: 241 GCYEISLGDTIGVGTPGSMKRMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINV 300
GCYEISLGDTIGVGTPGSMKRMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINV
Sbjct: 211 GCYEISLGDTIGVGTPGSMKRMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINV 270
Query: 301 VDSAVSGLGGCPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAVNKTTN 360
VDSAVSGLGGCPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAVNKTTN
Sbjct: 271 VDSAVSGLGGCPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAVNKTTN 330
Query: 361 SKVAQASFNA 370
SKVAQASFNA
Sbjct: 331 SKVAQASFNA 340
>gi|62198232 3-hydroxy-3-methylglutaryl CoA lyase [Homo sapiens]
Length = 325
Score = 447 bits (1150), Expect = e-126
Identities = 216/311 (69%), Positives = 261/311 (83%)
Query: 57 LAGTVACIHWETSQLSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVI 116
L G + TS + LP+ VKIVEVGPRDGLQNEK IV T +KI+ I+ LS+ GLSVI
Sbjct: 12 LVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVI 71
Query: 117 EVTSFVSSRWVPQMADHTEVMKGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAAS 176
E TSFVS +WVPQM DHTEV+KGI ++PG+ YPVLTPNL+GF AVAAGA E+ +FGAAS
Sbjct: 72 ETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAAS 131
Query: 177 ESFSKKNINCSIEESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSKR 236
E F+KKNINCSIEES +F+ ++K+A+ NI RGYVSCALGCPYEG I+P KV EV+K+
Sbjct: 132 ELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKK 191
Query: 237 LYGMGCYEISLGDTIGVGTPGSMKRMLESVMKEIPPGALAVHCHDTYGQALANILTALQM 296
Y MGCYEISLGDTIGVGTPG MK ML +VM+E+P ALAVHCHDTYGQALAN L ALQM
Sbjct: 192 FYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQM 251
Query: 297 GINVVDSAVSGLGGCPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAVN 356
G++VVDS+V+GLGGCPYA+GASGN+ATEDL+YML GLG++TGVNL K++EAG+FIC+A+N
Sbjct: 252 GVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALN 311
Query: 357 KTTNSKVAQAS 367
+ T+SKVAQA+
Sbjct: 312 RKTSSKVAQAT 322
>gi|106049528 pyruvate carboxylase precursor [Homo sapiens]
Length = 1178
Score = 47.4 bits (111), Expect = 2e-05
Identities = 43/174 (24%), Positives = 69/174 (39%), Gaps = 27/174 (15%)
Query: 209 ARGYVSCALGCPYEGSITPQKVTEVSKRLY--------GMGCYEISLGDTIGVGTPGSMK 260
A G V A+ Y G + T+ S + Y G + + + D G+ P +
Sbjct: 696 AGGVVEAAIS--YTGDVADPSRTKYSLQYYMGLAEELVRAGTHILCIKDMAGLLKPTACT 753
Query: 261 RMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSAVSGLGGCPYAKGASGN 320
++ S+ P L +H HDT G +A +L Q G +VVD A + G +
Sbjct: 754 MLVSSLRDRFPDLPLHIHTHDTSGAGVAAMLACAQAGADVVDVAADSM------SGMTSQ 807
Query: 321 VATEDLIYMLNGLGLNTGVNLYKVMEAGD-----------FICKAVNKTTNSKV 363
+ L+ G L+T V + +V + + F C A K+ NS V
Sbjct: 808 PSMGALVACTRGTPLDTEVPMERVFDYSEYWEGARGLYAAFDCTATMKSGNSDV 861
>gi|106049295 pyruvate carboxylase precursor [Homo sapiens]
Length = 1178
Score = 47.4 bits (111), Expect = 2e-05
Identities = 43/174 (24%), Positives = 69/174 (39%), Gaps = 27/174 (15%)
Query: 209 ARGYVSCALGCPYEGSITPQKVTEVSKRLY--------GMGCYEISLGDTIGVGTPGSMK 260
A G V A+ Y G + T+ S + Y G + + + D G+ P +
Sbjct: 696 AGGVVEAAIS--YTGDVADPSRTKYSLQYYMGLAEELVRAGTHILCIKDMAGLLKPTACT 753
Query: 261 RMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSAVSGLGGCPYAKGASGN 320
++ S+ P L +H HDT G +A +L Q G +VVD A + G +
Sbjct: 754 MLVSSLRDRFPDLPLHIHTHDTSGAGVAAMLACAQAGADVVDVAADSM------SGMTSQ 807
Query: 321 VATEDLIYMLNGLGLNTGVNLYKVMEAGD-----------FICKAVNKTTNSKV 363
+ L+ G L+T V + +V + + F C A K+ NS V
Sbjct: 808 PSMGALVACTRGTPLDTEVPMERVFDYSEYWEGARGLYAAFDCTATMKSGNSDV 861
>gi|106049292 pyruvate carboxylase precursor [Homo sapiens]
Length = 1178
Score = 47.4 bits (111), Expect = 2e-05
Identities = 43/174 (24%), Positives = 69/174 (39%), Gaps = 27/174 (15%)
Query: 209 ARGYVSCALGCPYEGSITPQKVTEVSKRLY--------GMGCYEISLGDTIGVGTPGSMK 260
A G V A+ Y G + T+ S + Y G + + + D G+ P +
Sbjct: 696 AGGVVEAAIS--YTGDVADPSRTKYSLQYYMGLAEELVRAGTHILCIKDMAGLLKPTACT 753
Query: 261 RMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSAVSGLGGCPYAKGASGN 320
++ S+ P L +H HDT G +A +L Q G +VVD A + G +
Sbjct: 754 MLVSSLRDRFPDLPLHIHTHDTSGAGVAAMLACAQAGADVVDVAADSM------SGMTSQ 807
Query: 321 VATEDLIYMLNGLGLNTGVNLYKVMEAGD-----------FICKAVNKTTNSKV 363
+ L+ G L+T V + +V + + F C A K+ NS V
Sbjct: 808 PSMGALVACTRGTPLDTEVPMERVFDYSEYWEGARGLYAAFDCTATMKSGNSDV 861
>gi|194272176 phospholipase D1 isoform b [Homo sapiens]
Length = 1036
Score = 33.9 bits (76), Expect = 0.24
Identities = 51/214 (23%), Positives = 85/214 (39%), Gaps = 37/214 (17%)
Query: 14 YQQLLREHLWIGDSVAGALDPAQTSLLTNLHCFQPDVSGFSVSLAGTVACIHWETSQLSG 73
Y+QL R HL DS++ + T G SL V +H ET G
Sbjct: 563 YKQLHRHHLHDADSISSIDSTSNT--------------GSIRSLQTGVGELHGETRFWHG 608
Query: 74 LPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQMADH 133
++ V +D +Q +K +FI+R S + ++ S V + +A H
Sbjct: 609 -KDYCNFVF---KDWVQLDKPFA------DFIDRYSTPRMPWHDIASAVHGKAARDVARH 658
Query: 134 -------TEVMKGIHQYPGVRYPVLTPNLQGFHHAV---AAGATEISVFGAASESFSKKN 183
T++MK +Y + YP L P Q H + G+ +V S +
Sbjct: 659 FIQRWNFTKIMKS--KYRSLSYPFLLPKSQTTAHELRYQVPGSVHANVQLLRSAADWSAG 716
Query: 184 INCSIEESMGKFEEVVKSARH-MNIPARGYVSCA 216
I E + V++++RH + I + ++SCA
Sbjct: 717 IKYHEESIHAAYVHVIENSRHYIYIENQFFISCA 750
>gi|115387102 adenylate cyclase 2 [Homo sapiens]
Length = 1091
Score = 29.3 bits (64), Expect = 5.9
Identities = 20/75 (26%), Positives = 30/75 (40%), Gaps = 8/75 (10%)
Query: 154 NLQGFHHAVAAGATEISVFGAASESFSKKNINCS-------IEESMGKFEEVVKSARHMN 206
N FH+ T +S+ A F++ +CS + E GKF+++ K M
Sbjct: 274 NTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMR 333
Query: 207 IPARG-YVSCALGCP 220
I G C G P
Sbjct: 334 IKILGDCYYCVSGLP 348
>gi|72255574 zinc finger protein 451 isoform 2 [Homo sapiens]
Length = 1013
Score = 29.3 bits (64), Expect = 5.9
Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 6/57 (10%)
Query: 232 EVSKRLYGMGCYEIS--LGDTIGVGTPGSM----KRMLESVMKEIPPGALAVHCHDT 282
E SK + G + S LGD G+ P S K++L S+ K++P V CH T
Sbjct: 267 ECSKHMSGKNHFHQSFKLGDNKGIAHPISFPSFAKKLLISLCKDVPFQVKCVACHKT 323
>gi|72255571 zinc finger protein 451 isoform 1 [Homo sapiens]
Length = 1061
Score = 29.3 bits (64), Expect = 5.9
Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 6/57 (10%)
Query: 232 EVSKRLYGMGCYEIS--LGDTIGVGTPGSM----KRMLESVMKEIPPGALAVHCHDT 282
E SK + G + S LGD G+ P S K++L S+ K++P V CH T
Sbjct: 267 ECSKHMSGKNHFHQSFKLGDNKGIAHPISFPSFAKKLLISLCKDVPFQVKCVACHKT 323
>gi|239756254 PREDICTED: similar to tubulin, beta 5 [Homo sapiens]
Length = 365
Score = 28.9 bits (63), Expect = 7.7
Identities = 24/83 (28%), Positives = 34/83 (40%), Gaps = 9/83 (10%)
Query: 194 KFEEVVKSARHMNIPARG----YVSCALGCPYEGSITPQKVTEVSKRLYGMGCYEISLGD 249
KF EV+ M++P+ G YV + E I K E L G L
Sbjct: 19 KFWEVISDGHSMDLPSEGTGDKYVPPTILVDPEPGIMDSKEAESCDCLQG-----FQLTH 73
Query: 250 TIGVGTPGSMKRMLESVMKEIPP 272
++G GT M +L S ++E P
Sbjct: 74 SLGEGTGSGMGTLLHSKIREEDP 96
>gi|239750785 PREDICTED: similar to tubulin, beta 5 [Homo sapiens]
Length = 365
Score = 28.9 bits (63), Expect = 7.7
Identities = 24/83 (28%), Positives = 34/83 (40%), Gaps = 9/83 (10%)
Query: 194 KFEEVVKSARHMNIPARG----YVSCALGCPYEGSITPQKVTEVSKRLYGMGCYEISLGD 249
KF EV+ M++P+ G YV + E I K E L G L
Sbjct: 19 KFWEVISDGHSMDLPSEGTGDKYVPPTILVDPEPGIMDSKEAESCDCLQG-----FQLTH 73
Query: 250 TIGVGTPGSMKRMLESVMKEIPP 272
++G GT M +L S ++E P
Sbjct: 74 SLGEGTGSGMGTLLHSKIREEDP 96
>gi|19913408 DNA topoisomerase II, beta isozyme [Homo sapiens]
Length = 1621
Score = 28.9 bits (63), Expect = 7.7
Identities = 42/209 (20%), Positives = 85/209 (40%), Gaps = 47/209 (22%)
Query: 46 FQPDVSGFSVSLAGT--VACIHWETSQLSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIE 103
FQPD+S F + VA + L+G VK++ G + + + V +K
Sbjct: 235 FQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNGKKLPVNGFRSYVDLYVK-- 292
Query: 104 FINRLSQTGLSVIEVTSFVSSRWVPQMADHTEVMKGIHQYPGVRYPV-LTPNLQGFHHAV 162
++L +TG++ +K IH+ R+ V LT + +GF
Sbjct: 293 --DKLDETGVA----------------------LKVIHELANERWDVCLTLSEKGFQ--- 325
Query: 163 AAGATEISVFGAASESFSKKNINCSIEESMGKFEEVVKSARHMNIPARG---------YV 213
+IS + + + ++++ +++ +GK EVVK + + ++
Sbjct: 326 -----QISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKKNKAGVSVKPFQVKNHIWVFI 380
Query: 214 SCALGCPYEGSITPQKVTEVSKRLYGMGC 242
+C + P S T + +T + + +G C
Sbjct: 381 NCLIENPTFDSQTKENMT-LQPKSFGSKC 408
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,370,002
Number of Sequences: 37866
Number of extensions: 556191
Number of successful extensions: 1276
Number of sequences better than 10.0: 13
Number of HSP's better than 10.0 without gapping: 6
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 1266
Number of HSP's gapped (non-prelim): 17
length of query: 370
length of database: 18,247,518
effective HSP length: 104
effective length of query: 266
effective length of database: 14,309,454
effective search space: 3806314764
effective search space used: 3806314764
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.