Search of human proteins with 109150422

Search of human proteins with 109150422

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|109150422 3-hydroxymethyl-3-methylglutaryl-Coenzyme A
lyase-like 1 isoform b [Homo sapiens]
         (340 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|109150422 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-l...   682   0.0  
gi|109150427 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-l...   666   0.0  
gi|62198232 3-hydroxy-3-methylglutaryl CoA lyase [Homo sapiens]       447   e-126
gi|106049528 pyruvate carboxylase precursor [Homo sapiens]             47   2e-05
gi|106049295 pyruvate carboxylase precursor [Homo sapiens]             47   2e-05
gi|106049292 pyruvate carboxylase precursor [Homo sapiens]             47   2e-05
gi|59806363 hypothetical protein LOC9729 [Homo sapiens]                30   3.1  
gi|122937398 dynein, cytoplasmic 2, heavy chain 1 [Homo sapiens]       30   3.1  
gi|115387102 adenylate cyclase 2 [Homo sapiens]                        29   5.3  
gi|72255574 zinc finger protein 451 isoform 2 [Homo sapiens]           29   5.3  
gi|72255571 zinc finger protein 451 isoform 1 [Homo sapiens]           29   5.3  
gi|239756254 PREDICTED: similar to tubulin, beta 5 [Homo sapiens]      29   6.9  
gi|239750785 PREDICTED: similar to tubulin, beta 5 [Homo sapiens]      29   6.9  

>gi|109150422 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like
           1 isoform b [Homo sapiens]
          Length = 340

 Score =  682 bits (1759), Expect = 0.0
 Identities = 340/340 (100%), Positives = 340/340 (100%)

Query: 1   MGNVPSAVKHCLSYQQLLREHLWIGDSVAGALDPAQETSQLSGLPEFVKIVEVGPRDGLQ 60
           MGNVPSAVKHCLSYQQLLREHLWIGDSVAGALDPAQETSQLSGLPEFVKIVEVGPRDGLQ
Sbjct: 1   MGNVPSAVKHCLSYQQLLREHLWIGDSVAGALDPAQETSQLSGLPEFVKIVEVGPRDGLQ 60

Query: 61  NEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQMADHTEVMKGIHQYPGVRYPV 120
           NEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQMADHTEVMKGIHQYPGVRYPV
Sbjct: 61  NEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQMADHTEVMKGIHQYPGVRYPV 120

Query: 121 LTPNLQGFHHAVAAGATEISVFGAASESFSKKNINCSIEESMGKFEEVVKSARHMNIPAR 180
           LTPNLQGFHHAVAAGATEISVFGAASESFSKKNINCSIEESMGKFEEVVKSARHMNIPAR
Sbjct: 121 LTPNLQGFHHAVAAGATEISVFGAASESFSKKNINCSIEESMGKFEEVVKSARHMNIPAR 180

Query: 181 GYVSCALGCPYEGSITPQKVTEVSKRLYGMGCYEISLGDTIGVGTPGSMKRMLESVMKEI 240
           GYVSCALGCPYEGSITPQKVTEVSKRLYGMGCYEISLGDTIGVGTPGSMKRMLESVMKEI
Sbjct: 181 GYVSCALGCPYEGSITPQKVTEVSKRLYGMGCYEISLGDTIGVGTPGSMKRMLESVMKEI 240

Query: 241 PPGALAVHCHDTYGQALANILTALQMGINVVDSAVSGLGGCPYAKGASGNVATEDLIYML 300
           PPGALAVHCHDTYGQALANILTALQMGINVVDSAVSGLGGCPYAKGASGNVATEDLIYML
Sbjct: 241 PPGALAVHCHDTYGQALANILTALQMGINVVDSAVSGLGGCPYAKGASGNVATEDLIYML 300

Query: 301 NGLGLNTGVNLYKVMEAGDFICKAVNKTTNSKVAQASFNA 340
           NGLGLNTGVNLYKVMEAGDFICKAVNKTTNSKVAQASFNA
Sbjct: 301 NGLGLNTGVNLYKVMEAGDFICKAVNKTTNSKVAQASFNA 340


>gi|109150427 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like
           1 isoform a [Homo sapiens]
          Length = 370

 Score =  666 bits (1718), Expect = 0.0
 Identities = 340/370 (91%), Positives = 340/370 (91%), Gaps = 30/370 (8%)

Query: 1   MGNVPSAVKHCLSYQQLLREHLWIGDSVAGALDPAQ------------------------ 36
           MGNVPSAVKHCLSYQQLLREHLWIGDSVAGALDPAQ                        
Sbjct: 1   MGNVPSAVKHCLSYQQLLREHLWIGDSVAGALDPAQTSLLTNLHCFQPDVSGFSVSLAGT 60

Query: 37  ------ETSQLSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTS 90
                 ETSQLSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTS
Sbjct: 61  VACIHWETSQLSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTS 120

Query: 91  FVSSRWVPQMADHTEVMKGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAASESFS 150
           FVSSRWVPQMADHTEVMKGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAASESFS
Sbjct: 121 FVSSRWVPQMADHTEVMKGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAASESFS 180

Query: 151 KKNINCSIEESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSKRLYGM 210
           KKNINCSIEESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSKRLYGM
Sbjct: 181 KKNINCSIEESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSKRLYGM 240

Query: 211 GCYEISLGDTIGVGTPGSMKRMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINV 270
           GCYEISLGDTIGVGTPGSMKRMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINV
Sbjct: 241 GCYEISLGDTIGVGTPGSMKRMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINV 300

Query: 271 VDSAVSGLGGCPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAVNKTTN 330
           VDSAVSGLGGCPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAVNKTTN
Sbjct: 301 VDSAVSGLGGCPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAVNKTTN 360

Query: 331 SKVAQASFNA 340
           SKVAQASFNA
Sbjct: 361 SKVAQASFNA 370


>gi|62198232 3-hydroxy-3-methylglutaryl CoA lyase [Homo sapiens]
          Length = 325

 Score =  447 bits (1151), Expect = e-126
 Identities = 215/303 (70%), Positives = 259/303 (85%)

Query: 35  AQETSQLSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSS 94
           A  TS +  LP+ VKIVEVGPRDGLQNEK IV T +KI+ I+ LS+ GLSVIE TSFVS 
Sbjct: 20  AVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSP 79

Query: 95  RWVPQMADHTEVMKGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAASESFSKKNI 154
           +WVPQM DHTEV+KGI ++PG+ YPVLTPNL+GF  AVAAGA E+ +FGAASE F+KKNI
Sbjct: 80  KWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNI 139

Query: 155 NCSIEESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSKRLYGMGCYE 214
           NCSIEES  +F+ ++K+A+  NI  RGYVSCALGCPYEG I+P KV EV+K+ Y MGCYE
Sbjct: 140 NCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYE 199

Query: 215 ISLGDTIGVGTPGSMKRMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSA 274
           ISLGDTIGVGTPG MK ML +VM+E+P  ALAVHCHDTYGQALAN L ALQMG++VVDS+
Sbjct: 200 ISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSS 259

Query: 275 VSGLGGCPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAVNKTTNSKVA 334
           V+GLGGCPYA+GASGN+ATEDL+YML GLG++TGVNL K++EAG+FIC+A+N+ T+SKVA
Sbjct: 260 VAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVA 319

Query: 335 QAS 337
           QA+
Sbjct: 320 QAT 322


>gi|106049528 pyruvate carboxylase precursor [Homo sapiens]
          Length = 1178

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 43/174 (24%), Positives = 69/174 (39%), Gaps = 27/174 (15%)

Query: 179 ARGYVSCALGCPYEGSITPQKVTEVSKRLY--------GMGCYEISLGDTIGVGTPGSMK 230
           A G V  A+   Y G +     T+ S + Y          G + + + D  G+  P +  
Sbjct: 696 AGGVVEAAIS--YTGDVADPSRTKYSLQYYMGLAEELVRAGTHILCIKDMAGLLKPTACT 753

Query: 231 RMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSAVSGLGGCPYAKGASGN 290
            ++ S+    P   L +H HDT G  +A +L   Q G +VVD A   +       G +  
Sbjct: 754 MLVSSLRDRFPDLPLHIHTHDTSGAGVAAMLACAQAGADVVDVAADSM------SGMTSQ 807

Query: 291 VATEDLIYMLNGLGLNTGVNLYKVMEAGD-----------FICKAVNKTTNSKV 333
            +   L+    G  L+T V + +V +  +           F C A  K+ NS V
Sbjct: 808 PSMGALVACTRGTPLDTEVPMERVFDYSEYWEGARGLYAAFDCTATMKSGNSDV 861


>gi|106049295 pyruvate carboxylase precursor [Homo sapiens]
          Length = 1178

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 43/174 (24%), Positives = 69/174 (39%), Gaps = 27/174 (15%)

Query: 179 ARGYVSCALGCPYEGSITPQKVTEVSKRLY--------GMGCYEISLGDTIGVGTPGSMK 230
           A G V  A+   Y G +     T+ S + Y          G + + + D  G+  P +  
Sbjct: 696 AGGVVEAAIS--YTGDVADPSRTKYSLQYYMGLAEELVRAGTHILCIKDMAGLLKPTACT 753

Query: 231 RMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSAVSGLGGCPYAKGASGN 290
            ++ S+    P   L +H HDT G  +A +L   Q G +VVD A   +       G +  
Sbjct: 754 MLVSSLRDRFPDLPLHIHTHDTSGAGVAAMLACAQAGADVVDVAADSM------SGMTSQ 807

Query: 291 VATEDLIYMLNGLGLNTGVNLYKVMEAGD-----------FICKAVNKTTNSKV 333
            +   L+    G  L+T V + +V +  +           F C A  K+ NS V
Sbjct: 808 PSMGALVACTRGTPLDTEVPMERVFDYSEYWEGARGLYAAFDCTATMKSGNSDV 861


>gi|106049292 pyruvate carboxylase precursor [Homo sapiens]
          Length = 1178

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 43/174 (24%), Positives = 69/174 (39%), Gaps = 27/174 (15%)

Query: 179 ARGYVSCALGCPYEGSITPQKVTEVSKRLY--------GMGCYEISLGDTIGVGTPGSMK 230
           A G V  A+   Y G +     T+ S + Y          G + + + D  G+  P +  
Sbjct: 696 AGGVVEAAIS--YTGDVADPSRTKYSLQYYMGLAEELVRAGTHILCIKDMAGLLKPTACT 753

Query: 231 RMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSAVSGLGGCPYAKGASGN 290
            ++ S+    P   L +H HDT G  +A +L   Q G +VVD A   +       G +  
Sbjct: 754 MLVSSLRDRFPDLPLHIHTHDTSGAGVAAMLACAQAGADVVDVAADSM------SGMTSQ 807

Query: 291 VATEDLIYMLNGLGLNTGVNLYKVMEAGD-----------FICKAVNKTTNSKV 333
            +   L+    G  L+T V + +V +  +           F C A  K+ NS V
Sbjct: 808 PSMGALVACTRGTPLDTEVPMERVFDYSEYWEGARGLYAAFDCTATMKSGNSDV 861


>gi|59806363 hypothetical protein LOC9729 [Homo sapiens]
          Length = 694

 Score = 30.0 bits (66), Expect = 3.1
 Identities = 15/51 (29%), Positives = 23/51 (45%)

Query: 13  SYQQLLREHLWIGDSVAGALDPAQETSQLSGLPEFVKIVEVGPRDGLQNEK 63
           SY+ +L EH W   +++G    A   S    + + +K  E      LQN K
Sbjct: 532 SYRNMLHEHDWRPSNLSGRPRSADPRSNYGVVEKLLKTYETATESALQNSK 582


>gi|122937398 dynein, cytoplasmic 2, heavy chain 1 [Homo sapiens]
          Length = 4314

 Score = 30.0 bits (66), Expect = 3.1
 Identities = 20/66 (30%), Positives = 36/66 (54%), Gaps = 4/66 (6%)

Query: 15   QQLLREHLWIGDSVAGALDPAQETSQLSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEF 74
            +QLL+E +  G S  GA+DP+   SQ+  L E +K  E    + +++  +     I+ + 
Sbjct: 1512 EQLLKECVTTGRSSQGAVDPSLFPSQILCLAEQIKFTE-DVENAIKDHSL---HQIETQL 1567

Query: 75   INRLSQ 80
            +N+L Q
Sbjct: 1568 VNKLEQ 1573


>gi|115387102 adenylate cyclase 2 [Homo sapiens]
          Length = 1091

 Score = 29.3 bits (64), Expect = 5.3
 Identities = 20/75 (26%), Positives = 30/75 (40%), Gaps = 8/75 (10%)

Query: 124 NLQGFHHAVAAGATEISVFGAASESFSKKNINCS-------IEESMGKFEEVVKSARHMN 176
           N   FH+      T +S+  A    F++   +CS       + E  GKF+++ K    M 
Sbjct: 274 NTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMR 333

Query: 177 IPARG-YVSCALGCP 190
           I   G    C  G P
Sbjct: 334 IKILGDCYYCVSGLP 348


>gi|72255574 zinc finger protein 451 isoform 2 [Homo sapiens]
          Length = 1013

 Score = 29.3 bits (64), Expect = 5.3
 Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 6/57 (10%)

Query: 202 EVSKRLYGMGCYEIS--LGDTIGVGTPGSM----KRMLESVMKEIPPGALAVHCHDT 252
           E SK + G   +  S  LGD  G+  P S     K++L S+ K++P     V CH T
Sbjct: 267 ECSKHMSGKNHFHQSFKLGDNKGIAHPISFPSFAKKLLISLCKDVPFQVKCVACHKT 323


>gi|72255571 zinc finger protein 451 isoform 1 [Homo sapiens]
          Length = 1061

 Score = 29.3 bits (64), Expect = 5.3
 Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 6/57 (10%)

Query: 202 EVSKRLYGMGCYEIS--LGDTIGVGTPGSM----KRMLESVMKEIPPGALAVHCHDT 252
           E SK + G   +  S  LGD  G+  P S     K++L S+ K++P     V CH T
Sbjct: 267 ECSKHMSGKNHFHQSFKLGDNKGIAHPISFPSFAKKLLISLCKDVPFQVKCVACHKT 323


>gi|239756254 PREDICTED: similar to tubulin, beta 5 [Homo sapiens]
          Length = 365

 Score = 28.9 bits (63), Expect = 6.9
 Identities = 24/83 (28%), Positives = 34/83 (40%), Gaps = 9/83 (10%)

Query: 164 KFEEVVKSARHMNIPARG----YVSCALGCPYEGSITPQKVTEVSKRLYGMGCYEISLGD 219
           KF EV+     M++P+ G    YV   +    E  I   K  E    L G       L  
Sbjct: 19  KFWEVISDGHSMDLPSEGTGDKYVPPTILVDPEPGIMDSKEAESCDCLQG-----FQLTH 73

Query: 220 TIGVGTPGSMKRMLESVMKEIPP 242
           ++G GT   M  +L S ++E  P
Sbjct: 74  SLGEGTGSGMGTLLHSKIREEDP 96


>gi|239750785 PREDICTED: similar to tubulin, beta 5 [Homo sapiens]
          Length = 365

 Score = 28.9 bits (63), Expect = 6.9
 Identities = 24/83 (28%), Positives = 34/83 (40%), Gaps = 9/83 (10%)

Query: 164 KFEEVVKSARHMNIPARG----YVSCALGCPYEGSITPQKVTEVSKRLYGMGCYEISLGD 219
           KF EV+     M++P+ G    YV   +    E  I   K  E    L G       L  
Sbjct: 19  KFWEVISDGHSMDLPSEGTGDKYVPPTILVDPEPGIMDSKEAESCDCLQG-----FQLTH 73

Query: 220 TIGVGTPGSMKRMLESVMKEIPP 242
           ++G GT   M  +L S ++E  P
Sbjct: 74  SLGEGTGSGMGTLLHSKIREEDP 96


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.390 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,233,953
Number of Sequences: 37866
Number of extensions: 508815
Number of successful extensions: 1179
Number of sequences better than 10.0: 13
Number of HSP's better than 10.0 without gapping: 8
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 1167
Number of HSP's gapped (non-prelim): 17
length of query: 340
length of database: 18,247,518
effective HSP length: 103
effective length of query: 237
effective length of database: 14,347,320
effective search space: 3400314840
effective search space used: 3400314840
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.