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Search of human proteins with 4557659
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4557659 iduronate-2-sulfatase isoform a precursor [Homo
sapiens]
(550 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4557659 iduronate-2-sulfatase isoform a precursor [Homo sapiens] 1143 0.0
gi|5360208 iduronate-2-sulfatase isoform b precursor [Homo sapiens] 694 0.0
gi|169217295 PREDICTED: similar to iduronate 2-sulfatase (Hunter... 178 1e-44
gi|157266309 arylsulfatase E precursor [Homo sapiens] 101 2e-21
gi|39930577 arylsulfatase K [Homo sapiens] 99 1e-20
gi|53831991 steryl-sulfatase precursor [Homo sapiens] 91 2e-18
gi|71852584 arylsulfatase D isoform a precursor [Homo sapiens] 91 2e-18
gi|4503899 galactosamine (N-acetyl)-6-sulfate sulfatase precurso... 82 1e-15
gi|189571643 sulfatase 1 [Homo sapiens] 77 3e-14
gi|189571641 sulfatase 1 [Homo sapiens] 77 3e-14
gi|189571638 sulfatase 1 [Homo sapiens] 77 3e-14
gi|189571636 sulfatase 1 [Homo sapiens] 77 3e-14
gi|4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo sap... 77 3e-14
gi|31742482 arylsulfatase F precursor [Homo sapiens] 76 9e-14
gi|71852586 arylsulfatase D isoform b precursor [Homo sapiens] 76 9e-14
gi|38569407 arylsulfatase B isoform 2 precursor [Homo sapiens] 69 1e-11
gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens] 68 2e-11
gi|240255483 sulfatase 2 isoform a precursor [Homo sapiens] 65 2e-10
gi|240255478 sulfatase 2 isoform b precursor [Homo sapiens] 65 2e-10
gi|29789100 sulfatase 2 isoform a precursor [Homo sapiens] 65 2e-10
gi|58743319 arylsulfatase family, member H [Homo sapiens] 65 2e-10
gi|146229331 arylsulfatase A isoform a precursor [Homo sapiens] 63 6e-10
gi|146229329 arylsulfatase A isoform a precursor [Homo sapiens] 63 6e-10
gi|146229324 arylsulfatase A isoform a precursor [Homo sapiens] 63 6e-10
gi|6005990 arylsulfatase A isoform a precursor [Homo sapiens] 63 6e-10
gi|45430057 Arylsulfatase G [Homo sapiens] 62 1e-09
gi|109389362 arylsulfatase J [Homo sapiens] 57 4e-08
gi|59797060 arylsulfatase family, member I [Homo sapiens] 55 2e-07
gi|4504061 glucosamine (N-acetyl)-6-sulfatase precursor [Homo sa... 55 2e-07
gi|146229327 arylsulfatase A isoform b [Homo sapiens] 39 0.012
>gi|4557659 iduronate-2-sulfatase isoform a precursor [Homo sapiens]
Length = 550
Score = 1143 bits (2956), Expect = 0.0
Identities = 550/550 (100%), Positives = 550/550 (100%)
Query: 1 MPPPRTGRGLLWLGLVLSSVCVALGSETQANSTTDALNVLLIIVDDLRPSLGCYGDKLVR 60
MPPPRTGRGLLWLGLVLSSVCVALGSETQANSTTDALNVLLIIVDDLRPSLGCYGDKLVR
Sbjct: 1 MPPPRTGRGLLWLGLVLSSVCVALGSETQANSTTDALNVLLIIVDDLRPSLGCYGDKLVR 60
Query: 61 SPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIP 120
SPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIP
Sbjct: 61 SPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIP 120
Query: 121 QYFKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHA 180
QYFKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHA
Sbjct: 121 QYFKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHA 180
Query: 181 NLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQK 240
NLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQK
Sbjct: 181 NLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQK 240
Query: 241 LYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSY 300
LYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSY
Sbjct: 241 LYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSY 300
Query: 301 FASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLI 360
FASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLI
Sbjct: 301 FASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLI 360
Query: 361 FYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPP 420
FYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPP
Sbjct: 361 FYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPP 420
Query: 421 RCPVPSFHVELCREGKNLLKHFRFRDLEEDPYLPGNPRELIAYSQYPRPSDIPQWNSDKP 480
RCPVPSFHVELCREGKNLLKHFRFRDLEEDPYLPGNPRELIAYSQYPRPSDIPQWNSDKP
Sbjct: 421 RCPVPSFHVELCREGKNLLKHFRFRDLEEDPYLPGNPRELIAYSQYPRPSDIPQWNSDKP 480
Query: 481 SLKDIKIMGYSIRTIDYRYTVWVGFNPDEFLANFSDIHAGELYFVDSDPLQDHNMYNDSQ 540
SLKDIKIMGYSIRTIDYRYTVWVGFNPDEFLANFSDIHAGELYFVDSDPLQDHNMYNDSQ
Sbjct: 481 SLKDIKIMGYSIRTIDYRYTVWVGFNPDEFLANFSDIHAGELYFVDSDPLQDHNMYNDSQ 540
Query: 541 GGDLFQLLMP 550
GGDLFQLLMP
Sbjct: 541 GGDLFQLLMP 550
>gi|5360208 iduronate-2-sulfatase isoform b precursor [Homo sapiens]
Length = 343
Score = 694 bits (1792), Expect = 0.0
Identities = 336/339 (99%), Positives = 338/339 (99%)
Query: 1 MPPPRTGRGLLWLGLVLSSVCVALGSETQANSTTDALNVLLIIVDDLRPSLGCYGDKLVR 60
MPPPRTGRGLLWLGLVLSSVCVALGSETQANSTTDALNVLLIIVDDLRPSLGCYGDKLVR
Sbjct: 1 MPPPRTGRGLLWLGLVLSSVCVALGSETQANSTTDALNVLLIIVDDLRPSLGCYGDKLVR 60
Query: 61 SPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIP 120
SPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIP
Sbjct: 61 SPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIP 120
Query: 121 QYFKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHA 180
QYFKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHA
Sbjct: 121 QYFKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHA 180
Query: 181 NLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQK 240
NLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQK
Sbjct: 181 NLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQK 240
Query: 241 LYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSY 300
LYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSY
Sbjct: 241 LYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSY 300
Query: 301 FASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWAL 339
FASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHG+ +
Sbjct: 301 FASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGFLM 339
>gi|169217295 PREDICTED: similar to iduronate 2-sulfatase (Hunter
syndrome) [Homo sapiens]
Length = 142
Score = 178 bits (451), Expect = 1e-44
Identities = 85/98 (86%), Positives = 91/98 (92%), Gaps = 2/98 (2%)
Query: 56 DKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGN 115
D+LV++PNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGN
Sbjct: 19 DELVKAPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGN 78
Query: 116 FSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYSW 153
FSTIPQYFKENGYVTMSVGKVFHPG + +S +SW
Sbjct: 79 FSTIPQYFKENGYVTMSVGKVFHPGTAPR--PESGFSW 114
>gi|157266309 arylsulfatase E precursor [Homo sapiens]
Length = 589
Score = 101 bits (251), Expect = 2e-21
Identities = 119/459 (25%), Positives = 186/459 (40%), Gaps = 96/459 (20%)
Query: 12 WLGLVLSSVCVALGSETQANSTTDALNVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASH 70
WL +L+ V ++L ++ + N+LL++ DDL +GCYG+ +R+PNID+LA
Sbjct: 14 WLPAMLA-VLLSLAPSASSDISASRPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAED 72
Query: 71 SLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSY----WRVHAG----NFSTIPQY 122
+ + ++C PSR +FLTGR P + + Y W +G N +T +
Sbjct: 73 GVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKI 132
Query: 123 FKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGP-------- 174
KE GY T +GK +H G++ D + P +H Y + G
Sbjct: 133 LKEKGYATGLIGK-WHLGLNCESASDHCH---HPLHHGFDHFYGMPFSLMGDCARWELSE 188
Query: 175 ---DGELHANLLCPVDVLD------------VPEGTLPDKQSTEQAIQLLEKMKTSASPF 219
+ E N L V L +P +P S A+ LL ++S F
Sbjct: 189 KRVNLEQKLNFLFQVLALVALTLVAGKLTHLIPVSWMPVIWSALSAVLLL-----ASSYF 243
Query: 220 FLAVGYH------KPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQR 273
A+ H + H P FQ+ PL EV L + P++
Sbjct: 244 VGALIVHADCFLMRNHTITEQPMCFQRTTPLIL------QEVASFLKRNKHGPFLLF--- 294
Query: 274 EDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTS 333
V L++ +P + + + Y +V +D VGR+L LD L+NST+I FTS
Sbjct: 295 --VSFLHVHIPLITMENFLGKSLHGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTS 352
Query: 334 DHGWAL------GEHGEW-------AKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPY 380
DHG +L ++G W ++ VP IF PG
Sbjct: 353 DHGGSLENQLGNTQYGGWNGIYKGGKGMGGWEGGIRVPGIFRWPG--------------- 397
Query: 381 LDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVP 419
++ GR + L+ +FPT+ LAG +VP
Sbjct: 398 ---------VLPAGRVIGEPTSLMDVFPTVVRLAGGEVP 427
>gi|39930577 arylsulfatase K [Homo sapiens]
Length = 536
Score = 98.6 bits (244), Expect = 1e-20
Identities = 99/424 (23%), Positives = 182/424 (42%), Gaps = 67/424 (15%)
Query: 10 LLWLGLV--LSSVCVALGSETQANSTTDALNVLLIIVDDLRPSLGCY-GDKLVRSPNIDQ 66
LLW+ +V L+ +A G+ Q A NV+L++ D L + G ++V+ P I+
Sbjct: 3 LLWVSVVAALALAVLAPGAGEQRRRAAKAPNVVLVVSDSFDGRLTFHPGSQVVKLPFINF 62
Query: 67 LASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKEN 126
+ + F NA+ +C PSR + +G T +N++ + N++T + +
Sbjct: 63 MKTRGTSFLNAYTNSPICCPSRAAMWSGLFTHLTE--SWNNFKGLDP-NYTTWMDVMERH 119
Query: 127 GYVTMSVGKVFHPGISSNHT-DDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHANLLCP 185
GY T GK+ + S +H+ + +W+ + +G NL+
Sbjct: 120 GYRTQKFGKLDYT--SGHHSISNRVEAWT-----------RDVAFLLRQEGRPMVNLIRN 166
Query: 186 VDVLDVPEGTLPDKQSTEQAIQLLEKMKTS-ASPFFLAVGYHKPHIPFRYPKEFQK---- 240
+ V E D Q+T++A+ L K + PF + +G + PH P+ P +
Sbjct: 167 RTKVRVMER---DWQNTDKAVNWLRKEAINYTEPFVIYLGLNLPH-PYPSPSSGENFGSS 222
Query: 241 -----LYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRK 295
LY LE ++ D + ++P ++ + + + G +
Sbjct: 223 TFHTSLYWLEKVS-------HDAIKIPKWSPLSEMHPVDYYSSYTKNCT-GRFTKKEIKN 274
Query: 296 IRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVAT 355
IR Y+A + D +G ++ AL L L TI+ ++SDHG EH ++ K S ++ +
Sbjct: 275 IRAFYYAMCAETDAMLGEIILALHQLDLLQKTIVIYSSDHGELAMEHRQFYKMSMYEASA 334
Query: 356 HVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAG 415
HVPL+ PG ++ G Q ++V LV ++PT+ +AG
Sbjct: 335 HVPLLMMGPG-------------------------IKAGLQVSNVVSLVDIYPTMLDIAG 369
Query: 416 LQVP 419
+ +P
Sbjct: 370 IPLP 373
>gi|53831991 steryl-sulfatase precursor [Homo sapiens]
Length = 583
Score = 91.3 bits (225), Expect = 2e-18
Identities = 109/420 (25%), Positives = 175/420 (41%), Gaps = 69/420 (16%)
Query: 38 NVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRR 96
N++L++ DDL GCYG+K +R+PNID+LAS + A +C PSR +F+TGR
Sbjct: 28 NIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRY 87
Query: 97 P--------DTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDD 148
P T ++ F + + T + K+ GY T +GK +H G+S + D
Sbjct: 88 PVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGK-WHLGMSCHSKTD 146
Query: 149 ---SPYSWSFPPYHPSSEKYENTKTCRGPDGELHAN-----LLCPVDVLDVPEGTLPDKQ 200
P F ++ S N + C+ +G + + P+ ++ V TL
Sbjct: 147 FCHHPLHHGFNYFYGIS--LTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTL---- 200
Query: 201 STEQAIQLLE-KMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGL 259
+ + LL + S FLA + F + + + N + P D L
Sbjct: 201 AALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNL 260
Query: 260 PPVAYNPWMDIRQREDVQALNISVPYGPIPV------DFQRKIRQS-YFASVSYLDTQVG 312
QR + + Y + DF K + Y +V +D VG
Sbjct: 261 TQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVG 320
Query: 313 RLLSALDDLQLANSTIIAFTSDHGWALGE-------HG------EWAKYSNFDVATHVPL 359
++L+ LD+L+LAN T+I FTSD G + E HG + K +N++ VP
Sbjct: 321 QILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPG 380
Query: 360 IFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVP 419
I R + +AG+K+ D + M+ +FPT+A LAG +P
Sbjct: 381 IL----RWPRVIQAGQKI-------DEPTSNMD-------------IFPTVAKLAGAPLP 416
>gi|71852584 arylsulfatase D isoform a precursor [Homo sapiens]
Length = 593
Score = 91.3 bits (225), Expect = 2e-18
Identities = 108/444 (24%), Positives = 178/444 (40%), Gaps = 73/444 (16%)
Query: 16 VLSSVCVALGSETQANSTTDALNVLLIIVDDLRPS-LGCYGDKLVRSPNIDQLASHSLLF 74
VL +C+ L + + N+LLI+ DDL LGCYG+ +R+PNIDQLA +
Sbjct: 20 VLLFLCLLLKTCEPKTANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGVRL 79
Query: 75 QNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSY----WRVHAG----NFSTIPQYFKEN 126
A +C PSR +FLTGR + + N Y W +G N +T + +++
Sbjct: 80 TQHLAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETTFARILQQH 139
Query: 127 GYVTMSVGKVFHPGISSNHTDD---SPYSWSFPPYHPSSEKYENTKTC---RGP--DGEL 178
GY T +GK +H G++ D P + F ++ + T C R P D L
Sbjct: 140 GYATGLIGK-WHQGVNCASRGDHCHHPLNHGFDYFY--GMPFTLTNDCDPGRPPEVDAAL 196
Query: 179 HANLLCPVDVLDVPEGTLPDKQST---EQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYP 235
A L L + TL Q+ + + + M FF++ + F +
Sbjct: 197 RAQLWGYTQFLALGILTLAAGQTCGFFSVSARAVTGMAGVGCLFFISW-----YSSFGFV 251
Query: 236 KEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQRED-------VQALNISVPYGPI 288
+ + + + N + P V + + + +R + L++ +P
Sbjct: 252 RRWNCIL-MRNHDVTEQPMVLEKTASLMLKEAVSYIERHKHGPFLLFLSLLHVHIPLVTT 310
Query: 289 PVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWAL------GEH 342
+ Y +V +D +G++L+A++D L NST FTSDHG L +
Sbjct: 311 SAFLGKSQHGLYGDNVEEMDWLIGKVLNAIEDNGLKNSTFTYFTSDHGGHLEARDGHSQL 370
Query: 343 GEW-------AKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGR 395
G W ++ VP IF+ PG ++ GR
Sbjct: 371 GGWNGIYKGGKGMGGWEGGIRVPGIFHWPG------------------------VLPAGR 406
Query: 396 QSMDLVELVSLFPTLAGLAGLQVP 419
+ L+ +FPT+ L G +VP
Sbjct: 407 VIGEPTSLMDVFPTVVQLVGGEVP 430
>gi|4503899 galactosamine (N-acetyl)-6-sulfate sulfatase precursor
[Homo sapiens]
Length = 522
Score = 82.0 bits (201), Expect = 1e-15
Identities = 109/429 (25%), Positives = 174/429 (40%), Gaps = 96/429 (22%)
Query: 12 WLGLVLSSVCVALGSETQANSTTDALNVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASH 70
W L+L +G A+ N+LL+++DD+ LG YG+ +PN+D++A+
Sbjct: 10 WWQLLLVLSAAGMG----ASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAE 65
Query: 71 SLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFST------------ 118
LLF N ++ +C+PSR + LTGR P Y N+ HA N T
Sbjct: 66 GLLFPNFYSANPLCSPSRAALLTGRLPIRNGFYTTNA----HARNAYTPQEIVGGIPDSE 121
Query: 119 --IPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCR-GP- 174
+P+ K+ GYV+ VGK +H G + F P +++ + C GP
Sbjct: 122 QLLPELLKKAGYVSKIVGK-WHLG----------HRPQFHPLKHGFDEWFGSPNCHFGPY 170
Query: 175 DGELHANLLCPV----DVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHI 230
D + N+ PV +++ P T +A L + A F H P
Sbjct: 171 DNKARPNI--PVYRDWEMVGRYYEEFPINLKTGEA-NLTQIYLQEALDFIKRQARHHPFF 227
Query: 231 PFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPV 290
LY + T A P A P++ QR YG
Sbjct: 228 ----------LYWAVDATHA---------PVYASKPFLGTSQRG---------RYG---- 255
Query: 291 DFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWAL-------GEHG 343
D R+I S +G++L L DL +A++T + FTSD+G AL G +G
Sbjct: 256 DAVREIDDS-----------IGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNG 304
Query: 344 EW--AKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLV 401
+ K + F+ P + + PG + + +L +D F ++ L S +
Sbjct: 305 PFLCGKQTTFEGGMREPALAWWPGHVTA-GQVSHQLGSIMDLFTTSLALAGLTPPSDRAI 363
Query: 402 ELVSLFPTL 410
+ ++L PTL
Sbjct: 364 DGLNLLPTL 372
>gi|189571643 sulfatase 1 [Homo sapiens]
Length = 871
Score = 77.4 bits (189), Expect = 3e-14
Identities = 99/427 (23%), Positives = 155/427 (36%), Gaps = 82/427 (19%)
Query: 38 NVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRP 97
N++L++ DD LG V + + F NAF +C PSR S LTG+
Sbjct: 44 NIILVLTDDQDVELGSLQ---VMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYV 100
Query: 98 DTTRLYDFN------SYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPY 151
+Y N S+ +H T Y GY T GK ++ + P
Sbjct: 101 HNHNVYTNNENCSSPSWQAMHEPR--TFAVYLNNTGYRTAFFGKY----LNEYNGSYIPP 154
Query: 152 SWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQL-LE 210
W + ++ N CR E H D + D + E +
Sbjct: 155 GWREWLGLIKNSRFYNYTVCRNGIKEKHG--------FDYAKDYFTDLITNESINYFKMS 206
Query: 211 KMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDI 270
K P + + + PH P +F KLYP + + P Y P MD
Sbjct: 207 KRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYN---------YAPNMDK 257
Query: 271 RQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIA 330
+ + P PI ++F +++ ++ +D V RL + L + +T I
Sbjct: 258 HW-----IMQYTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNMLVETGELENTYII 312
Query: 331 FTSDHGWALGEHG-EWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQ 389
+T+DHG+ +G+ G K +D VP F++ G +
Sbjct: 313 YTADHGYHIGQFGLVKGKSMPYDFDIRVP--FFIRGPS---------------------- 348
Query: 390 LMEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHVELCREGKNLLKHFRFRDLEE 449
+EPG +V + L PT+ +AGL PP +GK++LK
Sbjct: 349 -VEPGSIVPQIVLNIDLAPTILDIAGLDTPPDV-----------DGKSVLKLL------- 389
Query: 450 DPYLPGN 456
DP PGN
Sbjct: 390 DPEKPGN 396
>gi|189571641 sulfatase 1 [Homo sapiens]
Length = 871
Score = 77.4 bits (189), Expect = 3e-14
Identities = 99/427 (23%), Positives = 155/427 (36%), Gaps = 82/427 (19%)
Query: 38 NVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRP 97
N++L++ DD LG V + + F NAF +C PSR S LTG+
Sbjct: 44 NIILVLTDDQDVELGSLQ---VMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYV 100
Query: 98 DTTRLYDFN------SYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPY 151
+Y N S+ +H T Y GY T GK ++ + P
Sbjct: 101 HNHNVYTNNENCSSPSWQAMHEPR--TFAVYLNNTGYRTAFFGKY----LNEYNGSYIPP 154
Query: 152 SWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQL-LE 210
W + ++ N CR E H D + D + E +
Sbjct: 155 GWREWLGLIKNSRFYNYTVCRNGIKEKHG--------FDYAKDYFTDLITNESINYFKMS 206
Query: 211 KMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDI 270
K P + + + PH P +F KLYP + + P Y P MD
Sbjct: 207 KRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYN---------YAPNMDK 257
Query: 271 RQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIA 330
+ + P PI ++F +++ ++ +D V RL + L + +T I
Sbjct: 258 HW-----IMQYTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNMLVETGELENTYII 312
Query: 331 FTSDHGWALGEHG-EWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQ 389
+T+DHG+ +G+ G K +D VP F++ G +
Sbjct: 313 YTADHGYHIGQFGLVKGKSMPYDFDIRVP--FFIRGPS---------------------- 348
Query: 390 LMEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHVELCREGKNLLKHFRFRDLEE 449
+EPG +V + L PT+ +AGL PP +GK++LK
Sbjct: 349 -VEPGSIVPQIVLNIDLAPTILDIAGLDTPPDV-----------DGKSVLKLL------- 389
Query: 450 DPYLPGN 456
DP PGN
Sbjct: 390 DPEKPGN 396
>gi|189571638 sulfatase 1 [Homo sapiens]
Length = 871
Score = 77.4 bits (189), Expect = 3e-14
Identities = 99/427 (23%), Positives = 155/427 (36%), Gaps = 82/427 (19%)
Query: 38 NVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRP 97
N++L++ DD LG V + + F NAF +C PSR S LTG+
Sbjct: 44 NIILVLTDDQDVELGSLQ---VMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYV 100
Query: 98 DTTRLYDFN------SYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPY 151
+Y N S+ +H T Y GY T GK ++ + P
Sbjct: 101 HNHNVYTNNENCSSPSWQAMHEPR--TFAVYLNNTGYRTAFFGKY----LNEYNGSYIPP 154
Query: 152 SWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQL-LE 210
W + ++ N CR E H D + D + E +
Sbjct: 155 GWREWLGLIKNSRFYNYTVCRNGIKEKHG--------FDYAKDYFTDLITNESINYFKMS 206
Query: 211 KMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDI 270
K P + + + PH P +F KLYP + + P Y P MD
Sbjct: 207 KRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYN---------YAPNMDK 257
Query: 271 RQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIA 330
+ + P PI ++F +++ ++ +D V RL + L + +T I
Sbjct: 258 HW-----IMQYTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNMLVETGELENTYII 312
Query: 331 FTSDHGWALGEHG-EWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQ 389
+T+DHG+ +G+ G K +D VP F++ G +
Sbjct: 313 YTADHGYHIGQFGLVKGKSMPYDFDIRVP--FFIRGPS---------------------- 348
Query: 390 LMEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHVELCREGKNLLKHFRFRDLEE 449
+EPG +V + L PT+ +AGL PP +GK++LK
Sbjct: 349 -VEPGSIVPQIVLNIDLAPTILDIAGLDTPPDV-----------DGKSVLKLL------- 389
Query: 450 DPYLPGN 456
DP PGN
Sbjct: 390 DPEKPGN 396
>gi|189571636 sulfatase 1 [Homo sapiens]
Length = 871
Score = 77.4 bits (189), Expect = 3e-14
Identities = 99/427 (23%), Positives = 155/427 (36%), Gaps = 82/427 (19%)
Query: 38 NVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRP 97
N++L++ DD LG V + + F NAF +C PSR S LTG+
Sbjct: 44 NIILVLTDDQDVELGSLQ---VMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYV 100
Query: 98 DTTRLYDFN------SYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPY 151
+Y N S+ +H T Y GY T GK ++ + P
Sbjct: 101 HNHNVYTNNENCSSPSWQAMHEPR--TFAVYLNNTGYRTAFFGKY----LNEYNGSYIPP 154
Query: 152 SWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQL-LE 210
W + ++ N CR E H D + D + E +
Sbjct: 155 GWREWLGLIKNSRFYNYTVCRNGIKEKHG--------FDYAKDYFTDLITNESINYFKMS 206
Query: 211 KMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDI 270
K P + + + PH P +F KLYP + + P Y P MD
Sbjct: 207 KRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYN---------YAPNMDK 257
Query: 271 RQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIA 330
+ + P PI ++F +++ ++ +D V RL + L + +T I
Sbjct: 258 HW-----IMQYTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNMLVETGELENTYII 312
Query: 331 FTSDHGWALGEHG-EWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQ 389
+T+DHG+ +G+ G K +D VP F++ G +
Sbjct: 313 YTADHGYHIGQFGLVKGKSMPYDFDIRVP--FFIRGPS---------------------- 348
Query: 390 LMEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHVELCREGKNLLKHFRFRDLEE 449
+EPG +V + L PT+ +AGL PP +GK++LK
Sbjct: 349 -VEPGSIVPQIVLNIDLAPTILDIAGLDTPPDV-----------DGKSVLKLL------- 389
Query: 450 DPYLPGN 456
DP PGN
Sbjct: 390 DPEKPGN 396
>gi|4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo
sapiens]
Length = 502
Score = 77.4 bits (189), Expect = 3e-14
Identities = 80/306 (26%), Positives = 120/306 (39%), Gaps = 61/306 (19%)
Query: 38 NVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRP 97
N LL++ DD G Y + + +P++D LA SLLF+NAF + C+PSR S LTG
Sbjct: 24 NALLLLADDGGFESGAYNNSAIATPHLDALARRSLLFRNAFTSVSSCSPSRASLLTGLPQ 83
Query: 98 DTTRLY-------DFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSP 150
+Y FNS+ +V ++P + G T +GK H G + + D
Sbjct: 84 HQNGMYGLHQDVHHFNSFDKVR-----SLPLLLSQAGVRTGIIGKK-HVGPETVYPFDFA 137
Query: 151 YSWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLE 210
Y+ EN VL V K + +Q +
Sbjct: 138 YT------------EENG------------------SVLQVGRNITRIKLLVRKFLQTQD 167
Query: 211 KMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDI 270
PFFL V +H PH ++ + +PD P AY+P
Sbjct: 168 D-----RPFFLYVAFHDPHRCGHSQPQYGTFCEKFGNGESGMGRIPDWTPQ-AYDP---- 217
Query: 271 RQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIA 330
L++ VPY R + + +V +D VG +L L D + N T++
Sbjct: 218 --------LDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLVLQELRDAGVLNDTLVI 269
Query: 331 FTSDHG 336
FTSD+G
Sbjct: 270 FTSDNG 275
>gi|31742482 arylsulfatase F precursor [Homo sapiens]
Length = 590
Score = 75.9 bits (185), Expect = 9e-14
Identities = 54/158 (34%), Positives = 85/158 (53%), Gaps = 14/158 (8%)
Query: 15 LVLSSVCVALGSETQANST-TDALNVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSL 72
LV S+ AL + QA+ D N++LI+VDDL LGCYG+ +R+P+ID+LA +
Sbjct: 7 LVFMSLVCALLNTCQAHRVHDDKPNIVLIMVDDLGIGDLGCYGNDTMRTPHIDRLAREGV 66
Query: 73 LFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNS-----YWRVHAG---NFSTIPQYFK 124
+ ++C+PSR +FLTGR P + + + V AG N +T+ K
Sbjct: 67 RLTQHISAASLCSPSRSAFLTGRYPIRSGMVSSGNRRVIQNLAVPAGLPLNETTLAALLK 126
Query: 125 ENGYVTMSVGKVFHPGISSNHTDDS---PYSWSFPPYH 159
+ GY T +GK +H G++ + D PY++ F Y+
Sbjct: 127 KQGYSTGLIGK-WHQGLNCDSRSDQCHHPYNYGFDYYY 163
Score = 43.9 bits (102), Expect = 4e-04
Identities = 33/120 (27%), Positives = 58/120 (48%), Gaps = 11/120 (9%)
Query: 300 YFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPL 359
Y +V +D+ VG++L A+DD L N+T++ FTSDHG L A+ ++
Sbjct: 311 YGDNVEEMDSMVGKILDAIDDFGLRNNTLVYFTSDHGGHLEARRGHAQLGGWNG------ 364
Query: 360 IFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVP 419
Y G+ E G ++ P + + + GR + L+ + PT+A ++G +P
Sbjct: 365 -IYKGGKGMGGWEGGIRV-PGIVRWPGK---VPAGRLIKEPTSLMDILPTVASVSGGSLP 419
>gi|71852586 arylsulfatase D isoform b precursor [Homo sapiens]
Length = 382
Score = 75.9 bits (185), Expect = 9e-14
Identities = 47/136 (34%), Positives = 71/136 (52%), Gaps = 10/136 (7%)
Query: 16 VLSSVCVALGSETQANSTTDALNVLLIIVDDLRPS-LGCYGDKLVRSPNIDQLASHSLLF 74
VL +C+ L + + N+LLI+ DDL LGCYG+ +R+PNIDQLA +
Sbjct: 20 VLLFLCLLLKTCEPKTANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGVRL 79
Query: 75 QNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSY----WRVHAG----NFSTIPQYFKEN 126
A +C PSR +FLTGR + + N Y W +G N +T + +++
Sbjct: 80 TQHLAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETTFARILQQH 139
Query: 127 GYVTMSVGKVFHPGIS 142
GY T +GK +H G++
Sbjct: 140 GYATGLIGK-WHQGVN 154
>gi|38569407 arylsulfatase B isoform 2 precursor [Homo sapiens]
Length = 413
Score = 68.9 bits (167), Expect = 1e-11
Identities = 106/437 (24%), Positives = 166/437 (37%), Gaps = 95/437 (21%)
Query: 38 NVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRR 96
+++ ++ DDL +G +G + +R+P++D LA+ +L N + Q +C PSR LTGR
Sbjct: 46 HLVFLLADDLGWNDVGFHGSR-IRTPHLDALAAGGVLLDNYYTQP-LCTPSRSQLLTGRY 103
Query: 97 PDTTRLYDFNSYWRVHAG----NFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYS 152
T L W + +PQ KE GY T VGK +H G+ +
Sbjct: 104 QIRTGL-QHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGK-WHLGMYRKECLPTRRG 161
Query: 153 W-SFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQS------TEQA 205
+ ++ Y SE Y + + C D L+ C +D D E K T++A
Sbjct: 162 FDTYFGYLLGSEDYYSHERCTLIDA-LNVT-RCALDFRDGEEVATGYKNMYSTNIFTKRA 219
Query: 206 IQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYN 265
I L+ P FL + H P + P+E+ K
Sbjct: 220 IALITN-HPPEKPLFLYLALQSVHEPLQVPEEYLK------------------------- 253
Query: 266 PWMDIRQREDVQALNISVPYGPIPVDF-QRKIRQSYFASVSYLDTQVGRLLSALDDLQLA 324
P DF Q K R Y VS +D VG + +AL L
Sbjct: 254 -----------------------PYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLW 290
Query: 325 NSTIIAFTSDH-GWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDP 383
N+T+ F++D+ G L W + GR SL E G + ++
Sbjct: 291 NNTVFIFSTDNGGQTLAGGNNWP----------------LRGRKWSLWEGGVRGVGFV-- 332
Query: 384 FDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHV-ELCREGK-----N 437
++ L + G ++ +L+ + PTL LA P+ F V + EG
Sbjct: 333 --ASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSPSPRIE 390
Query: 438 LLKHFRFRDLEEDPYLP 454
LL + ++ PY P
Sbjct: 391 LLHNIDPNFVDSSPYWP 407
>gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens]
Length = 533
Score = 68.2 bits (165), Expect = 2e-11
Identities = 99/406 (24%), Positives = 155/406 (38%), Gaps = 89/406 (21%)
Query: 38 NVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRR 96
+++ ++ DDL +G +G + +R+P++D LA+ +L N + Q +C PSR LTGR
Sbjct: 46 HLVFLLADDLGWNDVGFHGSR-IRTPHLDALAAGGVLLDNYYTQP-LCTPSRSQLLTGRY 103
Query: 97 PDTTRLYDFNSYWRVHAG----NFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYS 152
T L W + +PQ KE GY T VGK +H G+ +
Sbjct: 104 QIRTGL-QHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGK-WHLGMYRKECLPTRRG 161
Query: 153 W-SFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQS------TEQA 205
+ ++ Y SE Y + + C D L+ C +D D E K T++A
Sbjct: 162 FDTYFGYLLGSEDYYSHERCTLIDA-LNVT-RCALDFRDGEEVATGYKNMYSTNIFTKRA 219
Query: 206 IQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYN 265
I L+ P FL + H P + P+E+ K
Sbjct: 220 IALITN-HPPEKPLFLYLALQSVHEPLQVPEEYLK------------------------- 253
Query: 266 PWMDIRQREDVQALNISVPYGPIPVDF-QRKIRQSYFASVSYLDTQVGRLLSALDDLQLA 324
P DF Q K R Y VS +D VG + +AL L
Sbjct: 254 -----------------------PYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLW 290
Query: 325 NSTIIAFTSDH-GWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDP 383
N+T+ F++D+ G L W + GR SL E G + ++
Sbjct: 291 NNTVFIFSTDNGGQTLAGGNNWP----------------LRGRKWSLWEGGVRGVGFV-- 332
Query: 384 FDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHV 429
++ L + G ++ +L+ + PTL LA P+ F V
Sbjct: 333 --ASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDV 376
>gi|240255483 sulfatase 2 isoform a precursor [Homo sapiens]
Length = 870
Score = 65.1 bits (157), Expect = 2e-10
Identities = 92/447 (20%), Positives = 161/447 (36%), Gaps = 84/447 (18%)
Query: 38 NVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRP 97
N++L++ DD LG ++Q +H F NAF +C PSR S LTG+
Sbjct: 45 NIILVLTDDQDVELGSMQVMNKTRRIMEQGGAH---FINAFVTTPMCCPSRSSILTGKYV 101
Query: 98 DTTRLYDFNSY-----WRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYS 152
Y N W+ + T Y GY T GK ++ + P
Sbjct: 102 HNHNTYTNNENCSSPSWQAQHES-RTFAVYLNSTGYRTAFFGKY----LNEYNGSYVPPG 156
Query: 153 WSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQ-AIQLLEK 211
W + ++ N CR E H + D + L D + + + K
Sbjct: 157 WKEWVGLLKNSRFYNYTLCRNGVKEKHGS--------DYSKDYLTDLITNDSVSFFRTSK 208
Query: 212 MKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIR 271
P + + + PH P ++ +L+P + + P P W+
Sbjct: 209 KMYPHRPVLMVISHAAPHGPEDSAPQYSRLFPNASQHITPSYNYA----PNPDKHWI--- 261
Query: 272 QREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAF 331
+ + P PI ++F +++ ++ +D + + + L + ++T I +
Sbjct: 262 -------MRYTGPMKPIHMEFTNMLQRKRLQTLMSVDDSMETIYNMLVETGELDNTYIVY 314
Query: 332 TSDHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLM 391
T+DHG+ +G+ G K + + + FYV G +
Sbjct: 315 TADHGYHIGQFG-LVKGKSMPYEFDIRVPFYVRGPN-----------------------V 350
Query: 392 EPGRQSMDLVELVSLFPTLAGLAGLQVP-------------PRCPVPSFHVE-------- 430
E G + +V + L PT+ +AGL +P PV FH++
Sbjct: 351 EAGCLNPHIVLNIDLAPTILDIAGLDIPADMDGKSILKLLDTERPVNRFHLKKKMRVWRD 410
Query: 431 --LCREGKNLLKHFRFR-DLEEDPYLP 454
L GK L K + D +E+ +LP
Sbjct: 411 SFLVERGKLLHKRDNDKVDAQEENFLP 437
>gi|240255478 sulfatase 2 isoform b precursor [Homo sapiens]
Length = 867
Score = 65.1 bits (157), Expect = 2e-10
Identities = 92/447 (20%), Positives = 161/447 (36%), Gaps = 84/447 (18%)
Query: 38 NVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRP 97
N++L++ DD LG ++Q +H F NAF +C PSR S LTG+
Sbjct: 45 NIILVLTDDQDVELGSMQVMNKTRRIMEQGGAH---FINAFVTTPMCCPSRSSILTGKYV 101
Query: 98 DTTRLYDFNSY-----WRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYS 152
Y N W+ + T Y GY T GK ++ + P
Sbjct: 102 HNHNTYTNNENCSSPSWQAQHES-RTFAVYLNSTGYRTAFFGKY----LNEYNGSYVPPG 156
Query: 153 WSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQ-AIQLLEK 211
W + ++ N CR E H + D + L D + + + K
Sbjct: 157 WKEWVGLLKNSRFYNYTLCRNGVKEKHGS--------DYSKDYLTDLITNDSVSFFRTSK 208
Query: 212 MKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIR 271
P + + + PH P ++ +L+P + + P P W+
Sbjct: 209 KMYPHRPVLMVISHAAPHGPEDSAPQYSRLFPNASQHITPSYNYA----PNPDKHWI--- 261
Query: 272 QREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAF 331
+ + P PI ++F +++ ++ +D + + + L + ++T I +
Sbjct: 262 -------MRYTGPMKPIHMEFTNMLQRKRLQTLMSVDDSMETIYNMLVETGELDNTYIVY 314
Query: 332 TSDHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLM 391
T+DHG+ +G+ G K + + + FYV G +
Sbjct: 315 TADHGYHIGQFG-LVKGKSMPYEFDIRVPFYVRGPN-----------------------V 350
Query: 392 EPGRQSMDLVELVSLFPTLAGLAGLQVP-------------PRCPVPSFHVE-------- 430
E G + +V + L PT+ +AGL +P PV FH++
Sbjct: 351 EAGCLNPHIVLNIDLAPTILDIAGLDIPADMDGKSILKLLDTERPVNRFHLKKKMRVWRD 410
Query: 431 --LCREGKNLLKHFRFR-DLEEDPYLP 454
L GK L K + D +E+ +LP
Sbjct: 411 SFLVERGKLLHKRDNDKVDAQEENFLP 437
>gi|29789100 sulfatase 2 isoform a precursor [Homo sapiens]
Length = 870
Score = 65.1 bits (157), Expect = 2e-10
Identities = 92/447 (20%), Positives = 161/447 (36%), Gaps = 84/447 (18%)
Query: 38 NVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRP 97
N++L++ DD LG ++Q +H F NAF +C PSR S LTG+
Sbjct: 45 NIILVLTDDQDVELGSMQVMNKTRRIMEQGGAH---FINAFVTTPMCCPSRSSILTGKYV 101
Query: 98 DTTRLYDFNSY-----WRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYS 152
Y N W+ + T Y GY T GK ++ + P
Sbjct: 102 HNHNTYTNNENCSSPSWQAQHES-RTFAVYLNSTGYRTAFFGKY----LNEYNGSYVPPG 156
Query: 153 WSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQ-AIQLLEK 211
W + ++ N CR E H + D + L D + + + K
Sbjct: 157 WKEWVGLLKNSRFYNYTLCRNGVKEKHGS--------DYSKDYLTDLITNDSVSFFRTSK 208
Query: 212 MKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIR 271
P + + + PH P ++ +L+P + + P P W+
Sbjct: 209 KMYPHRPVLMVISHAAPHGPEDSAPQYSRLFPNASQHITPSYNYA----PNPDKHWI--- 261
Query: 272 QREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAF 331
+ + P PI ++F +++ ++ +D + + + L + ++T I +
Sbjct: 262 -------MRYTGPMKPIHMEFTNMLQRKRLQTLMSVDDSMETIYNMLVETGELDNTYIVY 314
Query: 332 TSDHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLM 391
T+DHG+ +G+ G K + + + FYV G +
Sbjct: 315 TADHGYHIGQFG-LVKGKSMPYEFDIRVPFYVRGPN-----------------------V 350
Query: 392 EPGRQSMDLVELVSLFPTLAGLAGLQVP-------------PRCPVPSFHVE-------- 430
E G + +V + L PT+ +AGL +P PV FH++
Sbjct: 351 EAGCLNPHIVLNIDLAPTILDIAGLDIPADMDGKSILKLLDTERPVNRFHLKKKMRVWRD 410
Query: 431 --LCREGKNLLKHFRFR-DLEEDPYLP 454
L GK L K + D +E+ +LP
Sbjct: 411 SFLVERGKLLHKRDNDKVDAQEENFLP 437
>gi|58743319 arylsulfatase family, member H [Homo sapiens]
Length = 562
Score = 65.1 bits (157), Expect = 2e-10
Identities = 43/124 (34%), Positives = 65/124 (52%), Gaps = 11/124 (8%)
Query: 38 NVLLIIVDDLRPS-LGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRR 96
N++L++ DDL L CYG+ V +PNID+LAS + A ++C PSR +FLTGR
Sbjct: 8 NIVLLMADDLGVGDLCCYGNNSVSTPNIDRLASEGVRLTQHLAAASMCTPSRAAFLTGRY 67
Query: 97 PDTTRL---YDFNSYWRVHAG------NFSTIPQYFKENGYVTMSVGKVFHPGISSNHTD 147
P + + Y+ N + G N +T + + GY T +GK +H G+S +
Sbjct: 68 PIRSGMVSAYNLNRAFTWLGGSGGLPTNETTFAKLLQHRGYRTGLIGK-WHLGLSCASRN 126
Query: 148 DSPY 151
D Y
Sbjct: 127 DHCY 130
Score = 40.0 bits (92), Expect = 0.006
Identities = 33/116 (28%), Positives = 57/116 (49%), Gaps = 11/116 (9%)
Query: 300 YFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPL 359
Y +V +D VG++L ALD +LAN T++ FTSD+G L + ++
Sbjct: 289 YGDNVEEMDWMVGKILDALDQERLANHTLVYFTSDNGGHLEPLDGAVQLGGWNG------ 342
Query: 360 IFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAG 415
Y G+ E G ++ P + + S ++E GR + L+ ++PTL+ + G
Sbjct: 343 -IYKGGKGMGGWEGGIRV-PGIFRWPS---VLEAGRVINEPTSLMDIYPTLSYIGG 393
>gi|146229331 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 63.2 bits (152), Expect = 6e-10
Identities = 61/213 (28%), Positives = 88/213 (41%), Gaps = 22/213 (10%)
Query: 38 NVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRR 96
N++LI DDL LGCYG +PN+DQLA+ L F + + ++C PSR + LTGR
Sbjct: 22 NIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGRL 81
Query: 97 PDTTRLYDFNSYWRVHAG---NFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYS- 152
P +Y G T+ + GY+T GK +H G+ P+
Sbjct: 82 PVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGK-WHLGVGPEGAFLPPHQG 140
Query: 153 ---WSFPPYHPSSEKYENTKTCRGP----DGELHANLLCPVDVL-----DVPEGTLPDKQ 200
+ PY +N TC P DG L+ P+ +L + LP +
Sbjct: 141 FHRFLGIPYSHDQGPCQNL-TCFPPATPCDGGCDQGLV-PIPLLANLSVEAQPPWLPGLE 198
Query: 201 STEQAI--QLLEKMKTSASPFFLAVGYHKPHIP 231
+ A L+ + PFFL H H P
Sbjct: 199 ARYMAFAHDLMADAQRQDRPFFLYYASHHTHYP 231
Score = 38.9 bits (89), Expect = 0.012
Identities = 35/135 (25%), Positives = 55/135 (40%), Gaps = 33/135 (24%)
Query: 293 QRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHG---WALGEHG-----E 344
+R R + S+ LD VG L++A+ DL L T++ FT+D+G + G
Sbjct: 240 ERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLR 299
Query: 345 WAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELV 404
K + ++ P + + PG A PG + +L +
Sbjct: 300 CGKGTTYEGGVREPALAFWPGHIA------------------------PG-VTHELASSL 334
Query: 405 SLFPTLAGLAGLQVP 419
L PTLA LAG +P
Sbjct: 335 DLLPTLAALAGAPLP 349
>gi|146229329 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 63.2 bits (152), Expect = 6e-10
Identities = 61/213 (28%), Positives = 88/213 (41%), Gaps = 22/213 (10%)
Query: 38 NVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRR 96
N++LI DDL LGCYG +PN+DQLA+ L F + + ++C PSR + LTGR
Sbjct: 22 NIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGRL 81
Query: 97 PDTTRLYDFNSYWRVHAG---NFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYS- 152
P +Y G T+ + GY+T GK +H G+ P+
Sbjct: 82 PVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGK-WHLGVGPEGAFLPPHQG 140
Query: 153 ---WSFPPYHPSSEKYENTKTCRGP----DGELHANLLCPVDVL-----DVPEGTLPDKQ 200
+ PY +N TC P DG L+ P+ +L + LP +
Sbjct: 141 FHRFLGIPYSHDQGPCQNL-TCFPPATPCDGGCDQGLV-PIPLLANLSVEAQPPWLPGLE 198
Query: 201 STEQAI--QLLEKMKTSASPFFLAVGYHKPHIP 231
+ A L+ + PFFL H H P
Sbjct: 199 ARYMAFAHDLMADAQRQDRPFFLYYASHHTHYP 231
Score = 38.9 bits (89), Expect = 0.012
Identities = 35/135 (25%), Positives = 55/135 (40%), Gaps = 33/135 (24%)
Query: 293 QRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHG---WALGEHG-----E 344
+R R + S+ LD VG L++A+ DL L T++ FT+D+G + G
Sbjct: 240 ERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLR 299
Query: 345 WAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELV 404
K + ++ P + + PG A PG + +L +
Sbjct: 300 CGKGTTYEGGVREPALAFWPGHIA------------------------PG-VTHELASSL 334
Query: 405 SLFPTLAGLAGLQVP 419
L PTLA LAG +P
Sbjct: 335 DLLPTLAALAGAPLP 349
>gi|146229324 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 63.2 bits (152), Expect = 6e-10
Identities = 61/213 (28%), Positives = 88/213 (41%), Gaps = 22/213 (10%)
Query: 38 NVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRR 96
N++LI DDL LGCYG +PN+DQLA+ L F + + ++C PSR + LTGR
Sbjct: 22 NIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGRL 81
Query: 97 PDTTRLYDFNSYWRVHAG---NFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYS- 152
P +Y G T+ + GY+T GK +H G+ P+
Sbjct: 82 PVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGK-WHLGVGPEGAFLPPHQG 140
Query: 153 ---WSFPPYHPSSEKYENTKTCRGP----DGELHANLLCPVDVL-----DVPEGTLPDKQ 200
+ PY +N TC P DG L+ P+ +L + LP +
Sbjct: 141 FHRFLGIPYSHDQGPCQNL-TCFPPATPCDGGCDQGLV-PIPLLANLSVEAQPPWLPGLE 198
Query: 201 STEQAI--QLLEKMKTSASPFFLAVGYHKPHIP 231
+ A L+ + PFFL H H P
Sbjct: 199 ARYMAFAHDLMADAQRQDRPFFLYYASHHTHYP 231
Score = 38.9 bits (89), Expect = 0.012
Identities = 35/135 (25%), Positives = 55/135 (40%), Gaps = 33/135 (24%)
Query: 293 QRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHG---WALGEHG-----E 344
+R R + S+ LD VG L++A+ DL L T++ FT+D+G + G
Sbjct: 240 ERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLR 299
Query: 345 WAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELV 404
K + ++ P + + PG A PG + +L +
Sbjct: 300 CGKGTTYEGGVREPALAFWPGHIA------------------------PG-VTHELASSL 334
Query: 405 SLFPTLAGLAGLQVP 419
L PTLA LAG +P
Sbjct: 335 DLLPTLAALAGAPLP 349
>gi|6005990 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 63.2 bits (152), Expect = 6e-10
Identities = 61/213 (28%), Positives = 88/213 (41%), Gaps = 22/213 (10%)
Query: 38 NVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRR 96
N++LI DDL LGCYG +PN+DQLA+ L F + + ++C PSR + LTGR
Sbjct: 22 NIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGRL 81
Query: 97 PDTTRLYDFNSYWRVHAG---NFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYS- 152
P +Y G T+ + GY+T GK +H G+ P+
Sbjct: 82 PVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGK-WHLGVGPEGAFLPPHQG 140
Query: 153 ---WSFPPYHPSSEKYENTKTCRGP----DGELHANLLCPVDVL-----DVPEGTLPDKQ 200
+ PY +N TC P DG L+ P+ +L + LP +
Sbjct: 141 FHRFLGIPYSHDQGPCQNL-TCFPPATPCDGGCDQGLV-PIPLLANLSVEAQPPWLPGLE 198
Query: 201 STEQAI--QLLEKMKTSASPFFLAVGYHKPHIP 231
+ A L+ + PFFL H H P
Sbjct: 199 ARYMAFAHDLMADAQRQDRPFFLYYASHHTHYP 231
Score = 38.9 bits (89), Expect = 0.012
Identities = 35/135 (25%), Positives = 55/135 (40%), Gaps = 33/135 (24%)
Query: 293 QRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHG---WALGEHG-----E 344
+R R + S+ LD VG L++A+ DL L T++ FT+D+G + G
Sbjct: 240 ERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLR 299
Query: 345 WAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELV 404
K + ++ P + + PG A PG + +L +
Sbjct: 300 CGKGTTYEGGVREPALAFWPGHIA------------------------PG-VTHELASSL 334
Query: 405 SLFPTLAGLAGLQVP 419
L PTLA LAG +P
Sbjct: 335 DLLPTLAALAGAPLP 349
>gi|45430057 Arylsulfatase G [Homo sapiens]
Length = 525
Score = 62.0 bits (149), Expect = 1e-09
Identities = 89/424 (20%), Positives = 153/424 (36%), Gaps = 121/424 (28%)
Query: 38 NVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGR- 95
N ++I+ DD+ LG + + N+D++AS + F + A + C+PSR S LTGR
Sbjct: 37 NFVIILADDMGWGDLGANWAETKDTANLDKMASEGMRFVDFHAAASTCSPSRASLLTGRL 96
Query: 96 --RPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGK-------VFHPGISS-NH 145
R TR + S + N +T+ + ++ GYVT +GK +HP ++
Sbjct: 97 GLRNGVTRNFAVTSVGGLPL-NETTLAEVLQQAGYVTGIIGKWHLGHHGSYHPNFRGFDY 155
Query: 146 TDDSPYSWSFPPYHPSSEKYENTKTCRGPDG-------ELHANLLCP----VDVLDVPEG 194
PYS + C DG + + ++ P +++++ P
Sbjct: 156 YFGIPYSHDMGCTDTPGYNHPPCPACPQGDGPSRNLQRDCYTDVALPLYENLNIVEQPVN 215
Query: 195 TLPDKQS-TEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDP 253
Q E+A Q +++ TS PF L V H+P P+ + AP
Sbjct: 216 LSSLAQKYAEKATQFIQRASTSGRPFLLYVALAHMHVPL----------PVTQLPAAP-- 263
Query: 254 EVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGR 313
+ R Y A + +D+ VG+
Sbjct: 264 -----------------------------------------RGRSLYGAGLWEMDSLVGQ 282
Query: 314 LLSALDDLQLANSTIIAFTSDHG------------------WALGEHGEWAKYSNFDVAT 355
+ +D + +T + FT D+G W + G AK + ++
Sbjct: 283 IKDKVDH-TVKENTFLWFTGDNGPWAQKCELAGSVGPFTGFWQTRQGGSPAKQTTWEGGH 341
Query: 356 HVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAG 415
VP + Y PGR P + S L+ ++ +FPT+ LA
Sbjct: 342 RVPALAYWPGRV---------------PVNVTSTA---------LLSVLDIFPTVVALAQ 377
Query: 416 LQVP 419
+P
Sbjct: 378 ASLP 381
>gi|109389362 arylsulfatase J [Homo sapiens]
Length = 599
Score = 57.0 bits (136), Expect = 4e-08
Identities = 91/405 (22%), Positives = 151/405 (37%), Gaps = 97/405 (23%)
Query: 30 ANSTTDALNVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSR 88
+ ++T +++ I+ DD +G +G + +++P +D+LA+ + +N + Q +C PSR
Sbjct: 69 STTSTSQPHLIFILADDQGFRDVGYHGSE-IKTPTLDKLAAEGVKLENYYVQP-ICTPSR 126
Query: 89 VSFLTGRRPDTTRLYDFNSYWRVHAGNF-----STIPQYFKENGYVTMSVGKVFHPGISS 143
F+TG+ T L +S R N +T+PQ KE GY T VGK +H G
Sbjct: 127 SQFITGKYQIHTGLQ--HSIIRPTQPNCLPLDNATLPQKLKEVGYSTHMVGK-WHLGF-- 181
Query: 144 NHTDDSPYSWSFPPYHPS---SEKYENTKTCRGPDGELHANLLCPVDVL-------DVPE 193
+ P F + S S Y C P +C D+ D
Sbjct: 182 YRKECMPTRRGFDTFFGSLLGSGDYYTHYKCDSPG-------MCGYDLYENDNAAWDYDN 234
Query: 194 GTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDP 253
G + T++ Q+L P FL + Y H P + P + + Y
Sbjct: 235 GIYSTQMYTQRVQQILAS-HNPTKPIFLYIAYQAVHSPLQAPGRYFEHYR---------- 283
Query: 254 EVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGR 313
+NI+ R+ Y A +S LD +
Sbjct: 284 -----------------------SIININ--------------RRRYAAMLSCLDEAINN 306
Query: 314 LLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEA 373
+ AL N++II ++SD+G G SN+ + G + E
Sbjct: 307 VTLALKTYGFYNNSIIIYSSDNGGQPTAGG-----SNWPLR----------GSKGTYWEG 351
Query: 374 GEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQV 418
G + ++ + L G +LV + +PTL LA Q+
Sbjct: 352 GIRAVGFV----HSPLLKNKGTVCKELVHITDWYPTLISLAEGQI 392
>gi|59797060 arylsulfatase family, member I [Homo sapiens]
Length = 569
Score = 55.1 bits (131), Expect = 2e-07
Identities = 94/395 (23%), Positives = 142/395 (35%), Gaps = 100/395 (25%)
Query: 38 NVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRP 97
+++ I+ DD Y + +P +D+LA+ + +N + Q +C PSR LTGR
Sbjct: 48 HIIFILTDDQGYHDVGYHGSDIETPTLDRLAAKGVKLENYYIQP-ICTPSRSQLLTGRYQ 106
Query: 98 DTTRLYDFNSYWRVHAGNF-----STIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYS 152
T L +S R N T+PQ +E GY T VGK +H G + P
Sbjct: 107 IHTGLQ--HSIIRPQQPNCLPLDQVTLPQKLQEAGYSTHMVGK-WHLGF--YRKECLPTR 161
Query: 153 WSFPPYHPS---SEKYENTKTCRGPDGELHANLLCPVDVLDVPEGT-----LPDKQSTEQ 204
F + S + Y C GP V D+ EG L + ST
Sbjct: 162 RGFDTFLGSLTGNVDYYTYDNCDGPG----------VCGFDLHEGENVAWGLSGQYSTML 211
Query: 205 AIQLLEKMKTSAS---PFFLAVGYHKPHIPFRYPKEFQKLY-PLENITLAPDPEVPDGLP 260
Q + S S P FL V + H P + P+E+ Y + N+
Sbjct: 212 YAQRASHILASHSPQRPLFLYVAFQAVHTPLQSPREYLYRYRTMGNVA------------ 259
Query: 261 PVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDD 320
R+ Y A V+ +D V + AL
Sbjct: 260 ------------------------------------RRKYAAMVTCMDEAVRNITWALKR 283
Query: 321 LQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPY 380
N+++I F+SD+G F ++ PL GR + E G + +
Sbjct: 284 YGFYNNSVIIFSSDNGG-----------QTFSGGSNWPL----RGRKGTYWEGGVRGLGF 328
Query: 381 LDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAG 415
+ + L R S L+ + +PTL GLAG
Sbjct: 329 V----HSPLLKRKQRTSRALMHITDWYPTLVGLAG 359
>gi|4504061 glucosamine (N-acetyl)-6-sulfatase precursor [Homo
sapiens]
Length = 552
Score = 55.1 bits (131), Expect = 2e-07
Identities = 93/420 (22%), Positives = 155/420 (36%), Gaps = 78/420 (18%)
Query: 10 LLWLGLVLSSVCVALGSETQANSTTDALNVLLIIVDDLRPSLGCYGDKLVRSPNIDQLAS 69
LL LG L VA G+ NV+L++ DD LG I ++
Sbjct: 28 LLVLGGCLGVFGVAAGTRRP--------NVVLLLTDDQDEVLGGMTPLKKTKALIGEMG- 78
Query: 70 HSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYD--------FNSYWRVHAGNFSTIPQ 121
+ F +A+ A+C PSR S LTG+ P + + S+ ++ N T P
Sbjct: 79 --MTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSKSWQKIQEPN--TFPA 134
Query: 122 YFKEN-GYVTMSVGKVF--HPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGEL 178
+ GY T GK + + + P WS+ + KY N
Sbjct: 135 ILRSMCGYQTFFAGKYLNEYGAPDAGGLEHVPLGWSYWYALEKNSKYYNYTLSINGKARK 194
Query: 179 HANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEF 238
H + DV ++ L+ K++ PFF+ + PH P+ ++
Sbjct: 195 HGENYSVDYLTDV---------LANVSLDFLD-YKSNFEPFFMMIATPAPHSPWTAAPQY 244
Query: 239 QKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQ 298
QK + +N+ AP + N IRQ + P + F +
Sbjct: 245 QKAF--QNV-FAPRNK---NFNIHGTNKHWLIRQAK--------TPMTNSSIQFLDNAFR 290
Query: 299 SYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHG---EWAKYSNFDVAT 355
+ ++ +D V +L+ L+ N+T I +TSD+G+ G+ + + FD+
Sbjct: 291 KRWQTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPIDKRQLYEFDI-- 348
Query: 356 HVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAG 415
VPL+ PG ++P + S LV + L PT+ +AG
Sbjct: 349 KVPLLVRGPG-------------------------IKPNQTSKMLVANIDLGPTILDIAG 383
>gi|146229327 arylsulfatase A isoform b [Homo sapiens]
Length = 423
Score = 38.9 bits (89), Expect = 0.012
Identities = 35/135 (25%), Positives = 55/135 (40%), Gaps = 33/135 (24%)
Query: 293 QRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHG---WALGEHG-----E 344
+R R + S+ LD VG L++A+ DL L T++ FT+D+G + G
Sbjct: 156 ERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLR 215
Query: 345 WAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELV 404
K + ++ P + + PG A PG + +L +
Sbjct: 216 CGKGTTYEGGVREPALAFWPGHIA------------------------PG-VTHELASSL 250
Query: 405 SLFPTLAGLAGLQVP 419
L PTLA LAG +P
Sbjct: 251 DLLPTLAALAGAPLP 265
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.138 0.432
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,088,416
Number of Sequences: 37866
Number of extensions: 1176984
Number of successful extensions: 2880
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 29
Number of HSP's successfully gapped in prelim test: 18
Number of HSP's that attempted gapping in prelim test: 2757
Number of HSP's gapped (non-prelim): 95
length of query: 550
length of database: 18,247,518
effective HSP length: 107
effective length of query: 443
effective length of database: 14,195,856
effective search space: 6288764208
effective search space used: 6288764208
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.