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Search of human proteins with 4557522
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4557522 deiodinase, iodothyronine, type I isoform a [Homo
sapiens]
(249 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4557522 deiodinase, iodothyronine, type I isoform a [Homo sap... 516 e-147
gi|89357935 deiodinase, iodothyronine, type I isoform c [Homo sa... 400 e-112
gi|89357938 deiodinase, iodothyronine, type I isoform d [Homo sa... 335 3e-92
gi|47132603 deiodinase, iodothyronine, type I isoform b [Homo sa... 280 1e-75
gi|55750011 deiodinase, iodothyronine, type III [Homo sapiens] 154 9e-38
gi|55749998 deiodinase, iodothyronine, type II isoform b [Homo s... 140 1e-33
gi|7549803 deiodinase, iodothyronine, type II isoform a [Homo sa... 140 1e-33
gi|7549805 deiodinase, iodothyronine, type II isoform a [Homo sa... 140 1e-33
gi|5803011 enolase 2 [Homo sapiens] 31 0.88
gi|119964726 insulin-like growth factor 2 receptor precursor [Ho... 29 4.4
gi|4502271 Na+/K+ -ATPase alpha 2 subunit proprotein [Homo sapiens] 29 4.4
gi|56682953 epidermal growth factor receptor pathway substrate 8... 28 9.7
gi|22748667 Na+/K+ -ATPase alpha 3 subunit [Homo sapiens] 28 9.7
gi|74319833 ubiquitin specific protease 9, Y-linked [Homo sapiens] 28 9.7
gi|145309311 ubiquitin specific protease 9, X-linked isoform 4 [... 28 9.7
gi|145309309 ubiquitin specific protease 9, X-linked isoform 3 [... 28 9.7
>gi|4557522 deiodinase, iodothyronine, type I isoform a [Homo
sapiens]
Length = 249
Score = 516 bits (1330), Expect = e-147
Identities = 249/249 (100%), Positives = 249/249 (100%)
Query: 1 MGLPQPGLWLKRLWVLLEVAVHVVVGKVLLILFPDRVKRNILAMGEKTGMTRNPHFSHDN 60
MGLPQPGLWLKRLWVLLEVAVHVVVGKVLLILFPDRVKRNILAMGEKTGMTRNPHFSHDN
Sbjct: 1 MGLPQPGLWLKRLWVLLEVAVHVVVGKVLLILFPDRVKRNILAMGEKTGMTRNPHFSHDN 60
Query: 61 WIPTFFSTQYFWFVLKVRWQRLEDTTELGGLAPNCPVVRLSGQRCNIWEFMQGNRPLVLN 120
WIPTFFSTQYFWFVLKVRWQRLEDTTELGGLAPNCPVVRLSGQRCNIWEFMQGNRPLVLN
Sbjct: 61 WIPTFFSTQYFWFVLKVRWQRLEDTTELGGLAPNCPVVRLSGQRCNIWEFMQGNRPLVLN 120
Query: 121 FGSCTUPSFMFKFDQFKRLIEDFSSIADFLVIYIEEAHASDGWAFKNNMDIRNHQNLQDR 180
FGSCT PSFMFKFDQFKRLIEDFSSIADFLVIYIEEAHASDGWAFKNNMDIRNHQNLQDR
Sbjct: 121 FGSCTUPSFMFKFDQFKRLIEDFSSIADFLVIYIEEAHASDGWAFKNNMDIRNHQNLQDR 180
Query: 181 LQAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYIIQEGRILYKGKSGPWNYNPEEV 240
LQAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYIIQEGRILYKGKSGPWNYNPEEV
Sbjct: 181 LQAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYIIQEGRILYKGKSGPWNYNPEEV 240
Query: 241 RAVLEKLHS 249
RAVLEKLHS
Sbjct: 241 RAVLEKLHS 249
>gi|89357935 deiodinase, iodothyronine, type I isoform c [Homo
sapiens]
Length = 201
Score = 400 bits (1028), Expect = e-112
Identities = 201/249 (80%), Positives = 201/249 (80%), Gaps = 48/249 (19%)
Query: 1 MGLPQPGLWLKRLWVLLEVAVHVVVGKVLLILFPDRVKRNILAMGEKTGMTRNPHFSHDN 60
MGLPQPGLWLKRLWVLLEVAVHVVVGKVLLILFPDRVKRNILAMGEKTGMTRNPHFSHDN
Sbjct: 1 MGLPQPGLWLKRLWVLLEVAVHVVVGKVLLILFPDRVKRNILAMGEKTGMTRNPHFSHDN 60
Query: 61 WIPTFFSTQYFWFVLKVRWQRLEDTTELGGLAPNCPVVRLSGQRCNIWEFMQGNRPLVLN 120
WIPTFFSTQYFWFVLKVRWQRLEDTTELGGLAPNCPVVRLSGQRCNIWEFMQ
Sbjct: 61 WIPTFFSTQYFWFVLKVRWQRLEDTTELGGLAPNCPVVRLSGQRCNIWEFMQ-------- 112
Query: 121 FGSCTUPSFMFKFDQFKRLIEDFSSIADFLVIYIEEAHASDGWAFKNNMDIRNHQNLQDR 180
DGWAFKNNMDIRNHQNLQDR
Sbjct: 113 ----------------------------------------DGWAFKNNMDIRNHQNLQDR 132
Query: 181 LQAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYIIQEGRILYKGKSGPWNYNPEEV 240
LQAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYIIQEGRILYKGKSGPWNYNPEEV
Sbjct: 133 LQAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYIIQEGRILYKGKSGPWNYNPEEV 192
Query: 241 RAVLEKLHS 249
RAVLEKLHS
Sbjct: 193 RAVLEKLHS 201
>gi|89357938 deiodinase, iodothyronine, type I isoform d [Homo
sapiens]
Length = 161
Score = 335 bits (858), Expect = 3e-92
Identities = 160/160 (100%), Positives = 160/160 (100%)
Query: 1 MGLPQPGLWLKRLWVLLEVAVHVVVGKVLLILFPDRVKRNILAMGEKTGMTRNPHFSHDN 60
MGLPQPGLWLKRLWVLLEVAVHVVVGKVLLILFPDRVKRNILAMGEKTGMTRNPHFSHDN
Sbjct: 1 MGLPQPGLWLKRLWVLLEVAVHVVVGKVLLILFPDRVKRNILAMGEKTGMTRNPHFSHDN 60
Query: 61 WIPTFFSTQYFWFVLKVRWQRLEDTTELGGLAPNCPVVRLSGQRCNIWEFMQGNRPLVLN 120
WIPTFFSTQYFWFVLKVRWQRLEDTTELGGLAPNCPVVRLSGQRCNIWEFMQGNRPLVLN
Sbjct: 61 WIPTFFSTQYFWFVLKVRWQRLEDTTELGGLAPNCPVVRLSGQRCNIWEFMQGNRPLVLN 120
Query: 121 FGSCTUPSFMFKFDQFKRLIEDFSSIADFLVIYIEEAHAS 160
FGSCT PSFMFKFDQFKRLIEDFSSIADFLVIYIEEAHAS
Sbjct: 121 FGSCTUPSFMFKFDQFKRLIEDFSSIADFLVIYIEEAHAS 160
>gi|47132603 deiodinase, iodothyronine, type I isoform b [Homo
sapiens]
Length = 185
Score = 280 bits (715), Expect = 1e-75
Identities = 137/137 (100%), Positives = 137/137 (100%)
Query: 113 GNRPLVLNFGSCTUPSFMFKFDQFKRLIEDFSSIADFLVIYIEEAHASDGWAFKNNMDIR 172
GNRPLVLNFGSCT PSFMFKFDQFKRLIEDFSSIADFLVIYIEEAHASDGWAFKNNMDIR
Sbjct: 49 GNRPLVLNFGSCTUPSFMFKFDQFKRLIEDFSSIADFLVIYIEEAHASDGWAFKNNMDIR 108
Query: 173 NHQNLQDRLQAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYIIQEGRILYKGKSGP 232
NHQNLQDRLQAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYIIQEGRILYKGKSGP
Sbjct: 109 NHQNLQDRLQAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYIIQEGRILYKGKSGP 168
Query: 233 WNYNPEEVRAVLEKLHS 249
WNYNPEEVRAVLEKLHS
Sbjct: 169 WNYNPEEVRAVLEKLHS 185
Score = 101 bits (252), Expect = 5e-22
Identities = 49/49 (100%), Positives = 49/49 (100%)
Query: 1 MGLPQPGLWLKRLWVLLEVAVHVVVGKVLLILFPDRVKRNILAMGEKTG 49
MGLPQPGLWLKRLWVLLEVAVHVVVGKVLLILFPDRVKRNILAMGEKTG
Sbjct: 1 MGLPQPGLWLKRLWVLLEVAVHVVVGKVLLILFPDRVKRNILAMGEKTG 49
>gi|55750011 deiodinase, iodothyronine, type III [Homo sapiens]
Length = 278
Score = 154 bits (388), Expect = 9e-38
Identities = 88/192 (45%), Positives = 116/192 (60%), Gaps = 5/192 (2%)
Query: 57 SHDNWIPTFFSTQYFWFVLKVRWQRLEDTTELGGLAPNCPVVRLSG-QRCNIWEFMQGNR 115
S DN + T S + W K+ + + GG APN VV G Q +I ++ QGNR
Sbjct: 77 SDDNRLCTLASLKAVWHGQKLDFFK---QAHEGGPAPNSEVVLPDGFQSQHILDYAQGNR 133
Query: 116 PLVLNFGSCTUPSFMFKFDQFKRLIEDFSSIADFLVIYIEEAHASDGWAFKNN-MDIRNH 174
PLVLNFGSCT P FM + F+RL+ + DFL+IYIEEAH SDGW ++ I H
Sbjct: 134 PLVLNFGSCTUPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYIIPQH 193
Query: 175 QNLQDRLQAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYIIQEGRILYKGKSGPWN 234
++L+DR+ AA +L +P C +V+DTM N SS Y A ERLY+IQ G I+Y+G GP
Sbjct: 194 RSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDG 253
Query: 235 YNPEEVRAVLEK 246
Y E+R LE+
Sbjct: 254 YQVSELRTWLER 265
>gi|55749998 deiodinase, iodothyronine, type II isoform b [Homo
sapiens]
Length = 309
Score = 140 bits (352), Expect = 1e-33
Identities = 79/185 (42%), Positives = 107/185 (57%), Gaps = 25/185 (13%)
Query: 87 ELGGLAPNCPVVRLS------------------GQRCNIWEFMQGNRPLVLNFGSCTUPS 128
+LG APN VV +S G C++ +F RPLV+NFGS T P
Sbjct: 112 KLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASPERPLVVNFGSATUPP 171
Query: 129 FMFKFDQFKRLIEDFSSIADFLVIYIEEAHASDGWAFKN----NMDIRNHQNLQDRLQAA 184
F + F++L+E+FSS+ADFL++YI+EAH SDGWA + +++ HQN +DR AA
Sbjct: 172 FTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSFEVKKHQNQEDRCAAA 231
Query: 185 HLLLAR---SPQCPVVVDTMQNQSSQLYAALPERLYIIQEGRILYKGKSGPWNYNPEEVR 241
LL R PQC VV D M N ++ Y ER+ I+Q +I Y G GP++YN +EVR
Sbjct: 232 QQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVR 291
Query: 242 AVLEK 246
LEK
Sbjct: 292 HWLEK 296
>gi|7549803 deiodinase, iodothyronine, type II isoform a [Homo
sapiens]
Length = 273
Score = 140 bits (352), Expect = 1e-33
Identities = 79/185 (42%), Positives = 107/185 (57%), Gaps = 25/185 (13%)
Query: 87 ELGGLAPNCPVVRLS------------------GQRCNIWEFMQGNRPLVLNFGSCTUPS 128
+LG APN VV +S G C++ +F RPLV+NFGS T P
Sbjct: 76 KLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASPERPLVVNFGSATUPP 135
Query: 129 FMFKFDQFKRLIEDFSSIADFLVIYIEEAHASDGWAFKN----NMDIRNHQNLQDRLQAA 184
F + F++L+E+FSS+ADFL++YI+EAH SDGWA + +++ HQN +DR AA
Sbjct: 136 FTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSFEVKKHQNQEDRCAAA 195
Query: 185 HLLLAR---SPQCPVVVDTMQNQSSQLYAALPERLYIIQEGRILYKGKSGPWNYNPEEVR 241
LL R PQC VV D M N ++ Y ER+ I+Q +I Y G GP++YN +EVR
Sbjct: 196 QQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVR 255
Query: 242 AVLEK 246
LEK
Sbjct: 256 HWLEK 260
>gi|7549805 deiodinase, iodothyronine, type II isoform a [Homo
sapiens]
Length = 273
Score = 140 bits (352), Expect = 1e-33
Identities = 79/185 (42%), Positives = 107/185 (57%), Gaps = 25/185 (13%)
Query: 87 ELGGLAPNCPVVRLS------------------GQRCNIWEFMQGNRPLVLNFGSCTUPS 128
+LG APN VV +S G C++ +F RPLV+NFGS T P
Sbjct: 76 KLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASPERPLVVNFGSATUPP 135
Query: 129 FMFKFDQFKRLIEDFSSIADFLVIYIEEAHASDGWAFKN----NMDIRNHQNLQDRLQAA 184
F + F++L+E+FSS+ADFL++YI+EAH SDGWA + +++ HQN +DR AA
Sbjct: 136 FTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSFEVKKHQNQEDRCAAA 195
Query: 185 HLLLAR---SPQCPVVVDTMQNQSSQLYAALPERLYIIQEGRILYKGKSGPWNYNPEEVR 241
LL R PQC VV D M N ++ Y ER+ I+Q +I Y G GP++YN +EVR
Sbjct: 196 QQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVR 255
Query: 242 AVLEK 246
LEK
Sbjct: 256 HWLEK 260
>gi|5803011 enolase 2 [Homo sapiens]
Length = 434
Score = 31.2 bits (69), Expect = 0.88
Identities = 18/46 (39%), Positives = 24/46 (52%), Gaps = 2/46 (4%)
Query: 119 LNFGSCTUPSFMFKFDQFKRLIEDFSSIADFLVIYIEEAHASDGWA 164
L+F S T PS DQ L +DF + D+ V+ IE+ D WA
Sbjct: 259 LDFKSPTDPSRYITGDQLGALYQDF--VRDYPVVSIEDPFDQDDWA 302
>gi|119964726 insulin-like growth factor 2 receptor precursor [Homo
sapiens]
Length = 2491
Score = 28.9 bits (63), Expect = 4.4
Identities = 17/58 (29%), Positives = 26/58 (44%), Gaps = 4/58 (6%)
Query: 95 CPVVRLSGQRCNIWEFMQGN----RPLVLNFGSCTUPSFMFKFDQFKRLIEDFSSIAD 148
CPVVR+ G C + + GN +PL LN + + + F +L D +D
Sbjct: 1217 CPVVRVEGDNCEVKDPRHGNLYDLKPLGLNDTIVSAGEYTYYFRVCGKLSSDVCPTSD 1274
>gi|4502271 Na+/K+ -ATPase alpha 2 subunit proprotein [Homo sapiens]
Length = 1020
Score = 28.9 bits (63), Expect = 4.4
Identities = 24/83 (28%), Positives = 38/83 (45%), Gaps = 17/83 (20%)
Query: 3 LPQPGLWLKRLWVLLEVAVHVVVGKVLLILFPDRVKRNILAM-------------GEKTG 49
+PQ L ++ + A VVVG ++ + DRV ++ + GE
Sbjct: 163 VPQQALVIREGEKMQINAEEVVVGDLVEVKGGDRVPADLRIISSHGCKVDNSSLTGESEP 222
Query: 50 MTRNPHFSHDNWIPT----FFST 68
TR+P F+H+N + T FFST
Sbjct: 223 QTRSPEFTHENPLETRNICFFST 245
>gi|56682953 epidermal growth factor receptor pathway substrate 8
[Homo sapiens]
Length = 822
Score = 27.7 bits (60), Expect = 9.7
Identities = 19/76 (25%), Positives = 33/76 (43%), Gaps = 21/76 (27%)
Query: 110 FMQGNRPLVLNFGSCTUPSFMFKF-------------DQFKRLIEDFSSIADFLVIYIEE 156
F G P +LNF T +++ + KRL + SS++++
Sbjct: 433 FRNGWEPPMLNFMGATMEQDLYQLAESVANVAEHQRKQEIKRLSTEHSSVSEY------- 485
Query: 157 AHASDGWAFKNNMDIR 172
H +DG+AF +N+ R
Sbjct: 486 -HPADGYAFSSNIYTR 500
>gi|22748667 Na+/K+ -ATPase alpha 3 subunit [Homo sapiens]
Length = 1013
Score = 27.7 bits (60), Expect = 9.7
Identities = 25/83 (30%), Positives = 37/83 (44%), Gaps = 17/83 (20%)
Query: 3 LPQPGLWLKRLWVLLEVAVHVVVGKVLLILFPDRVKRNILAM-------------GEKTG 49
+PQ L ++ + A VVVG ++ I DRV ++ + GE
Sbjct: 155 VPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTGESEP 214
Query: 50 MTRNPHFSHDNWIP----TFFST 68
TR+P +HDN + TFFST
Sbjct: 215 QTRSPDCTHDNPLETRNITFFST 237
>gi|74319833 ubiquitin specific protease 9, Y-linked [Homo sapiens]
Length = 2555
Score = 27.7 bits (60), Expect = 9.7
Identities = 11/15 (73%), Positives = 13/15 (86%)
Query: 168 NMDIRNHQNLQDRLQ 182
N+DIRNHQNL D L+
Sbjct: 1743 NVDIRNHQNLLDSLE 1757
>gi|145309311 ubiquitin specific protease 9, X-linked isoform 4 [Homo
sapiens]
Length = 2554
Score = 27.7 bits (60), Expect = 9.7
Identities = 11/15 (73%), Positives = 13/15 (86%)
Query: 168 NMDIRNHQNLQDRLQ 182
N+DIRNHQNL D L+
Sbjct: 1741 NVDIRNHQNLLDSLE 1755
>gi|145309309 ubiquitin specific protease 9, X-linked isoform 3 [Homo
sapiens]
Length = 2570
Score = 27.7 bits (60), Expect = 9.7
Identities = 11/15 (73%), Positives = 13/15 (86%)
Query: 168 NMDIRNHQNLQDRLQ 182
N+DIRNHQNL D L+
Sbjct: 1741 NVDIRNHQNLLDSLE 1755
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.139 0.449
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,551,270
Number of Sequences: 37866
Number of extensions: 381667
Number of successful extensions: 854
Number of sequences better than 10.0: 16
Number of HSP's better than 10.0 without gapping: 11
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 830
Number of HSP's gapped (non-prelim): 21
length of query: 249
length of database: 18,247,518
effective HSP length: 100
effective length of query: 149
effective length of database: 14,460,918
effective search space: 2154676782
effective search space used: 2154676782
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.